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Bruce Furie

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Jeffrey I Zwicker; Kenneth A Bauer; Elizabeth Buchbinder; Andrea Bullock; Federico Campigotto; Thomas Caughey; Jonathan Eneman; Craig M Kessler; Heinz-Joseph Lenz; Howard A Liebman; Simon Mantha; Donna Neuberg; Vidya Raghavan; Rachel Rosovsky; Bruce Furie
Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study).
Bruce Furie; Barbara C Furie
Formation of the clot.
Jaehyung Cho; Barbara C Furie; Mingdong Huang; Daniel R Kennedy; Lin Lin; Glenn Merrill-Skoloff; Bruce Furie
Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins.

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2013: Jeffrey I Zwicker; Kenneth A Bauer; Elizabeth Buchbinder; Andrea Bullock; Federico Campigotto; Thomas Caughey; Jonathan Eneman; Craig M Kessler; Heinz-Joseph Lenz; Howard A Liebman; Simon Mantha; Donna Neuberg; Vidya Raghavan; Rachel Rosovsky; Bruce Furie
Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study).
British journal of haematology 2013;160(4):530-7.
2012: Bruce Furie; Barbara C Furie
Formation of the clot.
Thrombosis research 2012;130 Suppl 1():S44-6.
2012: Jaehyung Cho; Barbara C Furie; Mingdong Huang; Daniel R Kennedy; Lin Lin; Glenn Merrill-Skoloff; Bruce Furie
Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins.
Blood 2012;120(3):647-55.
2012: Jeffrey I Zwicker; Françoise Dignat-George; Barbara C Furie; Romaric Lacroix; Bruce Furie
Measurement of platelet microparticles.
Methods in molecular biology (Clifton, N.J.) 2012;788():127-39.
2011: L Bellido-Martín; V Chen; R Jasuja; Bruce Furie; Barbara C Furie
Imaging fibrin formation and platelet and endothelial cell activation in vivo.
Thrombosis and haemostasis 2011;105(5):776-82.
2011: Ariela Arad; VALERIE PROULLE; Richard Furie; Barbara C Furie; Bruce Furie
β₂-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model.
Blood 2011;117(12):3453-9.
2010: Ben T Atkinson; Reema Jasuja; Vivien M Chen; Prathima Nandivada; Bruce Furie; Barbara C Furie
Laser-induced endothelial cell activation supports fibrin formation.
Blood 2010;116(22):4675-83.
2010: Reema Jasuja; Bruce Furie; Barbara C Furie
Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo.
Blood 2010;116(22):4665-74.
2009: Bruce Furie
Pathogenesis of thrombosis.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2009;():255-8.
2008: Bruce Furie; Barbara C Furie
Mechanisms of thrombus formation.
The New England journal of medicine 2008;359(9):938-49.
2008: Jacky Chi Ki Ngo; Mingdong Huang; David A Roth; Barbara C Furie; Bruce Furie
Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex.
Structure (London, England : 1993) 2008;16(4):597-606.
2008: Qing Huai; Aiwu Zhou; Lin Lin; Andrew P Mazar; Graham C Parry; Jennifer Callahan; David E Shaw; Bruce Furie; Barbara C Furie; Mingdong Huang
Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes.
Nature structural & molecular biology 2008;15(4):422-3.
2008: Jaehyung Cho; Barbara C Furie; Shaun R Coughlin; Bruce Furie
A critical role for extracellular protein disulfide isomerase during thrombus formation in mice.
The Journal of clinical investigation 2008;118(3):1123-31.
2007: Laurence Panicot-Dubois; Grace M Thomas; Barbara C Furie; Bruce Furie; Dominique Lombardo; Christophe Dubois
Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans.
The Journal of clinical investigation 2007;117(12):3708-19.
2007: Lin Lin; Qing Huai; Mingdong Huang; Bruce Furie; Barbara C Furie
Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII.
Journal of molecular biology 2007;371(3):717-24.
2007: Bruce Furie; Barbara C Furie
In vivo thrombus formation.
Journal of thrombosis and haemostasis : JTH 2007;5 Suppl 1():12-7.
2007: Aihua Zhu; Hongmin Sun; Richard M Raymond; Barbara C Furie; Bruce Furie; Mila Bronstein; Randal J Kaufman; Randal J Westrick; David Ginsburg
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.
Blood 2007;109(12):5270-5.
2007: Jeffrey Zwicker; Barbara C Furie; Bruce Furie
Cancer-associated thrombosis.
Critical reviews in oncology/hematology 2007;62(2):126-36.
2007: Christophe Dubois; Laurence Panicot-Dubois; Justin F Gainor; Barbara C Furie; Bruce Furie
Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model.
The Journal of clinical investigation 2007;117(4):953-60.
2007: Nari Harakawa; Akiko Shigeta; Masahiro Wato; Glenn Merrill-Skoloff; Barbara C Furie; Bruce Furie; Toshiro Okazaki; Naochika Domae; Masayuki Miyasaka; Takako Hirata
P-selectin glycoprotein ligand-1 mediates L-selectin-independent leukocyte rolling in high endothelial venules of peripheral lymph nodes.
International immunology 2007;19(3):321-9.
2007: Erik R Vandendries; Justin R Hamilton; Shaun R Coughlin; Bruce Furie; Barbara C Furie
Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):288-92.
2006: Karin Hansson; Ann-Marie Thämlitz; Bruce Furie; Barbara C Furie; Johan Stenflo
A single gamma-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide.
Biochemistry 2006;45(42):12828-39.
2006: Eva Czerwiec; Dario E Kalume; Peter Roepstorff; Björn Hambe; Bruce Furie; Barbara C Furie; Johan Stenflo
Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile.
The FEBS journal 2006;273(12):2779-88.
2006: Christophe Dubois; Laurence Panicot-Dubois; Glenn Merrill-Skoloff; Bruce Furie; Barbara C Furie
Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo.
Blood 2006;107(10):3902-6.
2006: Barbara C Furie; Bruce Furie
Tissue factor pathway vs. collagen pathway for in vivo platelet activation.
Blood cells, molecules & diseases 2006;36(2):135-8.
2006: Bruce Furie; Barbara C Furie
Cancer-associated thrombosis.
Blood cells, molecules & diseases 2006;36(2):177-81.
2006: Qing Huai; Andrew P Mazar; Alice Kuo; Graham C Parry; David E Shaw; Jennifer Callahan; Yongdong Li; Cai Yuan; Chuanbing Bian; Liqing Chen; Bruce Furie; Barbara C Furie; Douglas B Cines; Mingdong Huang
Structure of human urokinase plasminogen activator in complex with its receptor.
Science (New York, N.Y.) 2006;311(5761):656-9.
2006: Shahrokh Falati; Sonali Patil; Peter L Gross; Michelle Stapleton; Glenn Merrill-Skoloff; Natasha E Barrett; Katherine L Pixton; Hartmut Weiler; Brian C Cooley; Debra K Newman; Peter J Newman; Barbara C Furie; Bruce Furie; Jonathan M Gibbins
Platelet PECAM-1 inhibits thrombus formation in vivo.
Blood 2006;107(2):535-41.
2006: Bruce Furie; Barbara C Furie
Thrombus formation in a living mouse.
Pathophysiology of haemostasis and thrombosis 2006;35(1-2):1-4.
2005: Bruce Furie; Barbara C Furie
Thrombus formation in vivo.
The Journal of clinical investigation 2005;115(12):3355-62.
2005: Peter L Gross; Barbara C Furie; Glenn Merrill-Skoloff; Janet Chou; Bruce Furie
Leukocyte-versus microparticle-mediated tissue factor transfer during arteriolar thrombus development.
Journal of leukocyte biology 2005;78(6):1318-26.
2005: Mark Brown; Gail S Begley; Eva Czerwiec; Leisa M Stenberg; Margaret Jacobs; Dario E Kalume; Peter Roepstorff; Johan Stenflo; Barbara C Furie; Bruce Furie
Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation.
Biochemistry 2005;44(25):9150-9.
2005: Derek S Sim; Robert Flaumenhaft; Bruce Furie; Bruce Furie
Interactions of platelets, blood-borne tissue factor, and fibrin during arteriolar thrombus formation in vivo.
Microcirculation (New York, N.Y. : 1994) 2005;12(3):301-11.
2004: Janet Chou; Nigel Mackman; Glenn Merrill-Skoloff; Brian Pedersen; Barbara C Furie; Bruce Furie
Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation.
Blood 2004;104(10):3190-7.
2004: Jean G Sathish; Shahrokh Falati; Kevin Croce; Colin Crump; Barbara C Furie; Bruce Furie; Alastair W Poole
Antibody cross-linking of human platelet P-selectin induces calcium entry by a mechanism dependent upon Fcgamma receptor IIA.
Thrombosis and haemostasis 2004;92(3):598-605.
2004: Erik R Vandendries; Barbara C Furie; Bruce Furie
Role of P-selectin and PSGL-1 in coagulation and thrombosis.
Thrombosis and haemostasis 2004;92(3):459-66.
2004: Marianne A Grant; Karin Hansson; Barbara C Furie; Bruce Furie; Johan Stenflo; Alan Rigby
The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M.
The Journal of biological chemistry 2004;279(31):32464-73.
2004: Karin Hansson; Xiaosong Ma; Lena Eliasson; Eva Czerwiec; Bruce Furie; Barbara C Furie; Patrik Rorsman; Johan Stenflo
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus.
The Journal of biological chemistry 2004;279(31):32453-63.
2004: Karin Hansson; Bruce Furie; Barbara C Furie; Johan Stenflo
Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern.
Biochemical and biophysical research communications 2004;319(4):1081-7.
2004: Monica Schenone; Barbara C Furie; Bruce Furie
The blood coagulation cascade.
Current opinion in hematology 2004;11(4):272-7.
2004: Mingdong Huang; Barbara C Furie; Bruce Furie
Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody.
The Journal of biological chemistry 2004;279(14):14338-46.
2004: Bruce Furie; Barbara C Furie
Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation.
Trends in molecular medicine 2004;10(4):171-8.
2004: Derek S Sim; Glenn Merrill-Skoloff; Barbara C Furie; Bruce Furie; Robert Flaumenhaft
Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels.
Blood 2004;103(6):2127-34.
2004: Alessandro Celi; Roberto Lorenzet; Barbara C Furie; Bruce Furie
Microparticles and a P-selectin-mediated pathway of blood coagulation.
Disease markers 2004;20(6):347-52.
2004: Shahrokh Falati; Peter L Gross; Glenn Merrill-Skoloff; Derek S Sim; Robert Flaumenhaft; Alessandro Celi; Barbara C Furie; Bruce Furie
In vivo models of platelet function and thrombosis: study of real-time thrombus formation.
Methods in molecular biology (Clifton, N.J.) 2004;272():187-97.
2003: Boris Tchernychev; Bruce Furie; Barbara C Furie
Peritoneal macrophages express both P-selectin and PSGL-1.
The Journal of cell biology 2003;163(5):1145-55.
2003: Mingdong Huang; Alan Rigby; XAVIER MORELLI; Marianne A Grant; Guiqing Huang; Bruce Furie; Barbara Seaton; Barbara C Furie
Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
Nature structural biology 2003;10(9):751-6.
2003: Mark D Blostein; Barbara C Furie; Isabelle Rajotte; Bruce Furie
The Gla domain of factor IXa binds to factor VIIIa in the tenase complex.
The Journal of biological chemistry 2003;278(33):31297-302.
2003: Shahrokh Falati; Qingde Liu; Peter Gross; Glenn Merrill-Skoloff; Janet Chou; Erik R Vandendries; Alessandro Celi; Kevin Croce; Barbara C Furie; Bruce Furie
Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin.
The Journal of experimental medicine 2003;197(11):1585-98.
2003: Alessandro Celi; Glenn Merrill-Skoloff; Peter Gross; Shahrokh Falati; Derek S Sim; Robert Flaumenhaft; Barbara C Furie; Bruce Furie
Thrombus formation: direct real-time observation and digital analysis of thrombus assembly in a living mouse by confocal and widefield intravital microscopy.
Journal of thrombosis and haemostasis : JTH 2003;1(1):60-8.
2002: Eva Czerwiec; Gail S Begley; Mila Bronstein; Johan Stenflo; Kevin Taylor; Barbara C Furie; Bruce Furie
Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile.
European journal of biochemistry / FEBS 2002;269(24):6162-72.
2002: Takako Hirata; Barbara C Furie; Bruce Furie
P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4307-13.
2002: Shahrokh Falati; Peter Gross; Glenn Merrill-Skoloff; Barbara C Furie; Bruce Furie
Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse.
Nature medicine 2002;8(10):1175-81.
2002: Mark Brown; Björn Hambe; Bruce Furie; Barbara C Furie; Johan Stenflo; Leisa M Stenberg
Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for gamma-carboxyglutamic acid.
Toxicon : official journal of the International Society on Toxinology 2002;40(4):447-53.
2001: Bruce Furie; Barbara C Furie; Robert Flaumenhaft
A journey with platelet P-selectin: the molecular basis of granule secretion, signalling and cell adhesion.
Thrombosis and haemostasis 2001;86(1):214-21.
2001: L A Falls; Barbara C Furie; M Jacobs; Bruce Furie; Alan Rigby
The omega-loop region of the human prothrombin gamma-carboxyglutamic acid domain penetrates anionic phospholipid membranes.
The Journal of biological chemistry 2001;276(26):23895-902.
2000: Takako Hirata; Glenn Merrill-Skoloff; M Aab; J Yang; Barbara C Furie; Bruce Furie
P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration.
The Journal of experimental medicine 2000;192(11):1669-76.
2000: Mark D Blostein; Alan Rigby; M Jacobs; Bruce Furie; Barbara C Furie
The Gla domain of human prothrombin has a binding site for factor Va.
The Journal of biological chemistry 2000;275(48):38120-6.
2000: Gail S Begley; Barbara C Furie; Eva Czerwiec; K L Taylor; G L Furie; L Bronstein; Johan Stenflo; Bruce Furie
A conserved motif within the vitamin K-dependent carboxylase gene is widely distributed across animal phyla.
The Journal of biological chemistry 2000;275(46):36245-9.
2000: L A Falls; Bruce Furie; Barbara C Furie
Role of phosphatidylethanolamine in assembly and function of the factor IXa-factor VIIIa complex on membrane surfaces.
Biochemistry 2000;39(43):13216-22.
2000: Mark D Blostein; Alan Rigby; Barbara C Furie; Bruce Furie; G E Gilbert
Amphipathic helices support function of blood coagulation factor IXa.
Biochemistry 2000;39(39):12000-6.
2000: Dario E Kalume; Johan Stenflo; Eva Czerwiec; Björn Hambe; Barbara C Furie; Bruce Furie; Peter Roepstorff
Structure determination of two conotoxins from Conus textile by a combination of matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization mass spectrometry and biochemical methods.
Journal of mass spectrometry : JMS 2000;35(2):145-56.
1999: J Yang; Takako Hirata; Kevin Croce; Glenn Merrill-Skoloff; Boris Tchernychev; E Williams; Robert Flaumenhaft; Barbara C Furie; Bruce Furie
Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration.
The Journal of experimental medicine 1999;190(12):1769-82.
1999: Kevin Croce; Robert Flaumenhaft; M Rivers; Bruce Furie; Barbara C Furie; Ira M Herman; David A Potter
Inhibition of calpain blocks platelet secretion, aggregation, and spreading.
The Journal of biological chemistry 1999;274(51):36321-7.
1999: K A Bush; Johan Stenflo; D A Roth; Eva Czerwiec; A Harrist; Gail S Begley; Barbara C Furie; Bruce Furie
Hydrophobic amino acids define the carboxylation recognition site in the precursor of the gamma-carboxyglutamic-acid-containing conotoxin epsilon-TxIX from the marine cone snail Conus textile.
Biochemistry 1999;38(44):14660-6.
1999: Neil L Kelleher; R A Zubarev; K Bush; Bruce Furie; B C Furie; Fred W McLafferty; Christopher T Walsh
Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid.
Analytical chemistry 1999;71(19):4250-3.
1999: B A Bouchard; Bruce Furie; Barbara C Furie
Glutamyl substrate-induced exposure of a free cysteine residue in the vitamin K-dependent gamma-glutamyl carboxylase is critical for vitamin K epoxidation.
Biochemistry 1999;38(29):9517-23.
1999: Alan Rigby; Estelle Lucas-Meunier; Dario E Kalume; Eva Czerwiec; Björn Hambe; I Dahlqvist; Philippe Fossier; Gérard Baux; Peter Roepstorff; James D Baleja; Barbara C Furie; Bruce Furie; Johan Stenflo
A conotoxin from Conus textile with unusual posttranslational modifications reduces presynaptic Ca2+ influx.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5758-63.
1999: Robert Flaumenhaft; Bruce Furie; Barbara C Furie
Alpha-granule secretion from alpha-toxin permeabilized, MgATP-exposed platelets is induced independently by H+ and Ca2+.
Journal of cellular physiology 1999;179(1):1-10.
1999: Bruce Furie; B A Bouchard; Barbara C Furie
Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid.
Blood 1999;93(6):1798-808.
1999: Robert Flaumenhaft; Kevin Croce; E Chen; Bruce Furie; Barbara C Furie
Proteins of the exocytotic core complex mediate platelet alpha-granule secretion. Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4.
The Journal of biological chemistry 1999;274(4):2492-501.
1999: J Yang; Barbara C Furie; Bruce Furie
The biology of P-selectin glycoprotein ligand-1: its role as a selectin counterreceptor in leukocyte-endothelial and leukocyte-platelet interaction.
Thrombosis and haemostasis 1999;81(1):1-7.
1998: G Pellegrini; R Malandra; Alessandro Celi; Barbara C Furie; Bruce Furie; Roberto Lorenzet
12-Hydroxyeicosatetraenoic acid upregulates P-selectin-induced tissue factor activity on monocytes.
FEBS letters 1998;441(3):463-6.
1998: Kevin Croce; Steven J Freedman; Barbara C Furie; Bruce Furie
Interaction between soluble P-selectin and soluble P-selectin glycoprotein ligand 1: equilibrium binding analysis.
Biochemistry 1998;37(47):16472-80.
1997: Alan Rigby; James D Baleja; L Li; Lee G Pedersen; Barbara C Furie; Bruce Furie
Role of gamma-carboxyglutamic acid in the calcium-induced structural transition of conantokin G, a conotoxin from the marine snail Conus geographus.
Biochemistry 1997;36(50):15677-84.
1997: Barbara C Furie; J V Ratcliffe; J Tward; M J Jorgensen; L S Blaszkowsky; D DiMichele; Bruce Furie
The gamma-carboxylation recognition site is sufficient to direct vitamin K-dependent carboxylation on an adjacent glutamate-rich region of thrombin in a propeptide-thrombin chimera.
The Journal of biological chemistry 1997;272(45):28258-62.
1997: S Gillis; Barbara C Furie; Bruce Furie
Interactions of neutrophils and coagulation proteins.
Seminars in hematology 1997;34(4):336-42.
1997: Alessandro Celi; Roberto Lorenzet; Bruce Furie; Barbara C Furie
Platelet-leukocyte-endothelial cell interaction on the blood vessel wall.
Seminars in hematology 1997;34(4):327-35.
1997: I Sugiura; Bruce Furie; C T Walsh; Barbara C Furie
Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9069-74.
1997: Barbara C Furie; Bruce Furie
Structure and mechanism of action of the vitamin K-dependent gamma-glutamyl carboxylase: recent advances from mutagenesis studies.
Thrombosis and haemostasis 1997;78(1):595-8.
1997: Alan Rigby; James D Baleja; Barbara C Furie; Bruce Furie
Three-dimensional structure of a gamma-carboxyglutamic acid-containing conotoxin, conantokin G, from the marine snail Conus geographus: the metal-free conformer.
Biochemistry 1997;36(23):6906-14.
1997: S Li; B C Furie; Bruce Furie; Christopher T Walsh
The propeptide of the vitamin K-dependent carboxylase substrate accelerates formation of the gamma-glutamyl carbanion intermediate.
Biochemistry 1997;36(21):6384-90.
1997: L Li; Thomas A Darden; Steven J Freedman; Barbara C Furie; Bruce Furie; James D Baleja; H Smith; R G Hiskey; Lee G Pedersen
Refinement of the NMR solution structure of the gamma-carboxyglutamic acid domain of coagulation factor IX using molecular dynamics simulation with initial Ca2+ positions determined by a genetic algorithm.
Biochemistry 1997;36(8):2132-8.
1997: Barbara C Furie; A Kuliopulos; D A Roth; I Sugiura; C T Walsh; Bruce Furie
Purification of native bovine carboxylase and expression and purification of recombinant bovine carboxylase.
Methods in enzymology 1997;282():333-46.
1996: Steven J Freedman; D G Sanford; W W Bachovchin; Barbara C Furie; James D Baleja; Bruce Furie
Structure and function of the epidermal growth factor domain of P-selectin.
Biochemistry 1996;35(43):13733-44.
1996: J A Bristol; J V Ratcliffe; David A Roth; M A Jacobs; Barbara C Furie; Bruce Furie
Biosynthesis of prothrombin: intracellular localization of the vitamin K-dependent carboxylase and the sites of gamma-carboxylation.
Blood 1996;88(7):2585-93.
1996: Steven J Freedman; M D Blostein; James D Baleja; M Jacobs; Barbara C Furie; Bruce Furie
Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX.
The Journal of biological chemistry 1996;271(27):16227-36.
1996: J Yang; Jacques Galipeau; C A Kozak; Barbara C Furie; Bruce Furie
Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor.
Blood 1996;87(10):4176-86.
1996: Bruce Furie; Barbara C Furie
P-selectin induction of tissue factor biosynthesis and expression.
Haemostasis 1996;26 Suppl 1():60-5.
1995: Steven J Freedman; Barbara C Furie; Bruce Furie; James D Baleja
Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich domain of factor IX.
Biochemistry 1995;34(38):12126-37.
1995: C S Crovello; Barbara C Furie; Bruce Furie
Histidine phosphorylation of P-selectin upon stimulation of human platelets: a novel pathway for activation-dependent signal transduction.
Cell 1995;82(2):279-86.
1995: Steven J Freedman; Barbara C Furie; Bruce Furie; James D Baleja
Structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor IX by two-dimensional NMR spectroscopy.
The Journal of biological chemistry 1995;270(14):7980-7.
1995: David A Roth; M L Whirl; L J Velazquez-Estades; Christopher T Walsh; Bruce Furie; Barbara C Furie
Mutagenesis of vitamin K-dependent carboxylase demonstrates a carboxyl terminus-mediated interaction with vitamin K hydroquinone.
The Journal of biological chemistry 1995;270(10):5305-11.
1995: M Yamada; A Kuliopulos; N P Nelson; David A Roth; Bruce Furie; Barbara C Furie; Christopher T Walsh
Localization of the factor IX propeptide binding site on recombinant vitamin K dependent carboxylase using benzoylphenylalanine photoaffinity peptide inactivators.
Biochemistry 1995;34(2):481-9.
1994: J A Bristol; S J Freedman; Barbara C Furie; Bruce Furie
Profactor IX: the propeptide inhibits binding to membrane surfaces and activation by factor XIa.
Biochemistry 1994;33(47):14136-43.
1994: M Jacobs; Steven J Freedman; Barbara C Furie; Bruce Furie
Membrane binding properties of the factor IX gamma-carboxyglutamic acid-rich domain prepared by chemical synthesis.
The Journal of biological chemistry 1994;269(41):25494-501.
1994: Alessandro Celi; G Pellegrini; Roberto Lorenzet; A De Blasi; N Ready; Barbara C Furie; Bruce Furie
P-selectin induces the expression of tissue factor on monocytes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):8767-71.
1994: A Kuliopulos; N P Nelson; M Yamada; Christopher T Walsh; Bruce Furie; Barbara C Furie; David A Roth
Localization of the affinity peptide-substrate inactivator site on recombinant vitamin K-dependent carboxylase.
The Journal of biological chemistry 1994;269(33):21364-70.
1993: D Sako; X J Chang; K M Barone; G Vachino; H M White; G Shaw; G M Veldman; K M Bean; T J Ahern; Bruce Furie
Expression cloning of a functional glycoprotein ligand for P-selectin.
Cell 1993;75(6):1179-86.
1993: J V Ratcliffe; Bruce Furie; Barbara C Furie
The importance of specific gamma-carboxyglutamic acid residues in prothrombin. Evaluation by site-specific mutagenesis.
The Journal of biological chemistry 1993;268(32):24339-45.
1993: David A Roth; Alnawaz Rehemtulla; Randal J Kaufman; Christopher T Walsh; Bruce Furie; Barbara C Furie
Expression of bovine vitamin K-dependent carboxylase activity in baculovirus-infected insect cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8372-6.
1993: K J Kotkow; Bruce Furie; Barbara C Furie
The interaction of prothrombin with phospholipid membranes is independent of either kringle domain.
The Journal of biological chemistry 1993;268(21):15633-9.
1993: C S Crovello; Barbara C Furie; Bruce Furie
Rapid phosphorylation and selective dephosphorylation of P-selectin accompanies platelet activation.
The Journal of biological chemistry 1993;268(20):14590-3.
1993: Alnawaz Rehemtulla; David A Roth; L C Wasley; A Kuliopulos; Christopher T Walsh; Bruce Furie; Barbara C Furie; Randal J Kaufman
In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4611-5.
1993: C Bardelle; Bruce Furie; Barbara C Furie; G E Gilbert
Membrane binding kinetics of factor VIII indicate a complex binding process.
The Journal of biological chemistry 1993;268(12):8815-24.
1993: J A Bristol; Barbara C Furie; Bruce Furie
Propeptide processing during factor IX biosynthesis. Effect of point mutations adjacent to the propeptide cleavage site.
The Journal of biological chemistry 1993;268(10):7577-84.
1993: K J Kotkow; David A Roth; T J Porter; Barbara C Furie; Bruce Furie
Role of propeptide in vitamin K-dependent gamma-carboxylation.
Methods in enzymology 1993;222():435-49.
1992: T Palabrica; R Lobb; Barbara C Furie; Mark Aronovitz; C Benjamin; Y M Hsu; S A Sajer; Bruce Furie
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets.
Nature 1992;359(6398):848-51.
1992: A Kuliopulos; C E Cieurzo; Bruce Furie; Barbara C Furie; Christopher T Walsh
N-bromoacetyl-peptide substrate affinity labeling of vitamin K dependent carboxylase.
Biochemistry 1992;31(39):9436-44.
1992: A Kuliopulos; B R Hubbard; Z Lam; I J Koski; Bruce Furie; Barbara C Furie; Christopher T Walsh
Dioxygen transfer during vitamin K dependent carboxylase catalysis.
Biochemistry 1992;31(33):7722-8.
1992: M S Hertzberg; O Ben-Tal; Bruce Furie; Barbara C Furie
Construction, expression, and characterization of a chimera of factor IX and factor X. The role of the second epidermal growth factor domain and serine protease domain in factor Va binding.
The Journal of biological chemistry 1992;267(21):14759-66.
1992: G R Larsen; D Sako; T J Ahern; M Shaffer; J Erban; S A Sajer; R M Gibson; Denisa D Wagner; Barbara C Furie; Bruce Furie
P-selectin and E-selectin. Distinct but overlapping leukocyte ligand specificities.
The Journal of biological chemistry 1992;267(16):11104-10.
1992: Bruce Furie; Barbara C Furie
Molecular and cellular biology of blood coagulation.
The New England journal of medicine 1992;326(12):800-6.
1991: Alessandro Celi; Bruce Furie; Barbara C Furie
PADGEM: an adhesion receptor for leukocytes on stimulated platelets and endothelial cells.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1991;198(2):703-9.
1991: D G Sanford; C Kanagy; J L Sudmeier; Barbara C Furie; Bruce Furie; W W Bachovchin
Structure of the propeptide of prothrombin containing the gamma-carboxylation recognition site determined by two-dimensional NMR spectroscopy.
Biochemistry 1991;30(41):9835-41.
1991: G E Gilbert; P J Sims; T Wiedmer; Bruce Furie; Barbara C Furie; S J Shattil
Platelet-derived microparticles express high affinity receptors for factor VIII.
The Journal of biological chemistry 1991;266(26):17261-8.
1991: H Murakami; Z Lam; Barbara C Furie; V N Reinhold; T Asano; Bruce Furie
Sulfated glycolipids are the platelet autoantigens for human platelet-binding monoclonal anti-DNA autoantibodies.
The Journal of biological chemistry 1991;266(23):15414-9.
1991: Bruce Furie; Barbara C Furie
Molecular basis of gamma-carboxylation. Role of the propeptide in the vitamin K-dependent proteins.
Annals of the New York Academy of Sciences 1991;614():1-10.
1991: Bruce Furie; Alessandro Celi; T M Palabrica; E Larsen; Denisa D Wagner; Barbara C Furie
PADGEM, a leukocyte receptor on activated platelets. Biology and application to in vivo medical diagnostics.
Current studies in hematology and blood transfusion 1991;(58):32-6.
1990: E Larsen; T Palabrica; S Sajer; G E Gilbert; Denisa D Wagner; Barbara C Furie; Bruce Furie
PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15).
Cell 1990;63(3):467-74.
1990: P Huber; T Schmitz; J Griffin; M Jacobs; C Walsh; Bruce Furie; Barbara C Furie
Identification of amino acids in the gamma-carboxylation recognition site on the propeptide of prothrombin.
The Journal of biological chemistry 1990;265(21):12467-73.
1990: Bruce Furie; Barbara C Furie
Molecular basis of hemophilia.
Seminars in hematology 1990;27(3):270-85.
1990: Bruce Furie; Barbara C Furie
Molecular basis of vitamin K-dependent gamma-carboxylation.
Blood 1990;75(9):1753-62.
1990: Bruce Furie; C F Diuguid; M Jacobs; D L Diuguid; Barbara C Furie
Randomized prospective trial comparing the native prothrombin antigen with the prothrombin time for monitoring oral anticoagulant therapy.
Blood 1990;75(2):344-9.
1990: G E Gilbert; Barbara C Furie; Bruce Furie
Binding of human factor VIII to phospholipid vesicles.
The Journal of biological chemistry 1990;265(2):815-22.
1989: E Larsen; Alessandro Celi; G E Gilbert; Barbara C Furie; J K Erban; R Bonfanti; Denisa D Wagner; Bruce Furie
PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes.
Cell 1989;59(2):305-12.
1989: B R Hubbard; M M Ulrich; M Jacobs; Cees Vermeer; C Walsh; Bruce Furie; Barbara C Furie
Vitamin K-dependent carboxylase: affinity purification from bovine liver by using a synthetic propeptide containing the gamma-carboxylation recognition site.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):6893-7.
1989: B R Hubbard; M Jacobs; M M Ulrich; C Walsh; Bruce Furie; Barbara C Furie
Vitamin K-dependent carboxylation. In vitro modification of synthetic peptides containing the gamma-carboxylation recognition site.
The Journal of biological chemistry 1989;264(24):14145-50.
1989: J Ware; D L Diuguid; H A Liebman; M J Rabiet; C K Kasper; Barbara C Furie; Bruce Furie; Darrel W Stafford
Factor IX San Dimas. Substitution of glutamine for Arg-4 in the propeptide leads to incomplete gamma-carboxylation and altered phospholipid binding properties.
The Journal of biological chemistry 1989;264(19):11401-6.
1989: D L Diuguid; M J Rabiet; Barbara C Furie; Bruce Furie
Molecular defects of factor IX Chicago-2 (Arg 145----His) and prothrombin Madrid (Arg 271----cys): arginine mutations that preclude zymogen activation.
Blood 1989;74(1):193-200.
1989: R Bonfanti; Barbara C Furie; Bruce Furie; Denisa D Wagner
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells.
Blood 1989;73(5):1109-12.
1988: M M Ulrich; Bruce Furie; M R Jacobs; Cees Vermeer; Barbara C Furie
Vitamin K-dependent carboxylation. A synthetic peptide based upon the gamma-carboxylation recognition site sequence of the prothrombin propeptide is an active substrate for the carboxylase in vitro.
The Journal of biological chemistry 1988;263(20):9697-702.
1986: D L Diuguid; M J Rabiet; Barbara C Furie; H A Liebman; Bruce Furie
Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):5803-7.