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Junken Aoki

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Yohsuke Ohba; Takeshi Sakuragi; Naoko H Tomioka; Junken Aoki; Rieko Imae; Asuka Inoue; Takao Inoue; Naotada Ishihara; Eriko Kage-Nakadai; Nozomu Kono; Shohei Mitani; Hiroyuki Arai
Mitochondria-type GPAT is required for mitochondrial fusion.
Kumiko Makide; Junken Aoki
GPR34 as a lysophosphatidylserine receptor.
Guowei Jiang; Junken Aoki; Asuka Inoue; Glenn D Prestwich
Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): metabolically stabilized LPA receptor agonists.

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All Publications

2013: Yohsuke Ohba; Takeshi Sakuragi; Naoko H Tomioka; Junken Aoki; Rieko Imae; Asuka Inoue; Takao Inoue; Naotada Ishihara; Eriko Kage-Nakadai; Nozomu Kono; Shohei Mitani; Hiroyuki Arai
Mitochondria-type GPAT is required for mitochondrial fusion.
The EMBO journal 2013;32(9):1265-79.
2013: Kumiko Makide; Junken Aoki
GPR34 as a lysophosphatidylserine receptor.
Journal of biochemistry 2013;153(4):327-9.
2013: Guowei Jiang; Junken Aoki; Asuka Inoue; Glenn D Prestwich
Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): metabolically stabilized LPA receptor agonists.
Bioorganic & medicinal chemistry letters 2013;23(6):1865-9.
2013: Zhongbin Bai; Linjun Cai; Erina Hata; Haruko Hayasaka; Yutaka Komai; Akiko Kubo; Harald M H G Albers; Junken Aoki; Shinichi Okudaira; Huib Ovaa; Makoto Suematsu; Yuki Sugiura; Akira Takeda; Toshiyuki Tanaka; Kazuo Tohya; Eiji Umemoto; Punniyakoti Thanikachalam Veeraveedu; Masayuki Miyasaka
Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):2036-48.
2013: Hayakazu Sumida; Kunihiko Tamaki; Keisuke Yanagida; Junken Aoki; Yoshihide Asano; Koji Igarashi; Satoshi Ishii; Takafumi Kadono; Kazuhiro Nakamura; Ryunosuke Ohkawa; Shinichi Sato; Takao Shimizu; Yutaka Yatomi
Decrease in circulating autotaxin by oral administration of prednisolone.
Clinica chimica acta; international journal of clinical chemistry 2013;415():74-80.
2013: Yoshikazu Ono; Minoru Tozuka; Hiromitsu Yokota; Junken Aoki; Koji Igarashi; Makoto Kurano; Ryunosuke Ohkawa; Yutaka Yatomi
Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration.
Lipids in health and disease 2013;12():20.
2012: Hiroshi Nishimasu; Tomohiro Nishizawa; Kuniaki Saito; Haruhiko Siomi; Mikiko C Siomi; Junken Aoki; Luc BONNEFOND; Satoshi Fukuhara; Ryuichiro Ishitani; Hirotsugu Ishizu; Miharu K Kamatani; Naoki Matsumoto; Keita Nakanaga; Osamu Nureki
Structure and function of Zucchini endoribonuclease in piRNA biogenesis.
Nature 2012;491(7423):284-7.
2012: Kazuki Kato; Emiko Mihara; Hiroshi Nishimasu; Junken Aoki; Ryuichiro Ishitani; Shinichi Okudaira; Junichi Takagi; Osamu Nureki
Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):16876-81.
2012: Asuka Inoue; Jun Ishiguro; Hajime Kitamura; Kumiko Makide; Tomohiko Ohwada; Michiyo Okutani; Akira Shuto; Hiroyuki Arai; Naoaki Arima; Shigeki Higashiyama; Junken Aoki
TGFα shedding assay: an accurate and versatile method for detecting GPCR activation.
Nature methods 2012;9(10):1021-9.
2012: Atsushi Fujimoto; Motofumi Hagihara; Asuka Inoue; Masaaki Ito; Tokuro Iwabuchi; Jotaro Nakanishi; Manabu Ohyama; Junken Aoki; Ritsuko Ehama; Muhammad Farooq; Hiroki Fujikawa; Yutaka Shimomura
A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis.
The Journal of investigative dermatology 2012;132(10):2342-9.
2012: Kazuhiro Nakamura; Ryunosuke Ohkawa; Tetsu Yano; Junken Aoki; Koji Igarashi; Hitoshi Ikeda; Akiko Masuda; Shunsuke Nakagawa; Hiromitsu Yokota; Yutaka Yatomi
Serum autotaxin is not a useful biomarker for ovarian cancer.
Lipids 2012;47(9):927-30.
2012: Akira Sato; Junken Aoki; Keiichi Ebina
Synthetic biotinylated peptide compound, BP21, specifically recognizes lysophosphatidylcholine micelles.
Chemical biology & drug design 2012;80(3):417-25.
2012: Satoru Shinkuma; Hideyuki Ujiie; Riichiro Abe; Masashi Akiyama; Junken Aoki; Asuka Inoue; Ken Natsuga; Wataru Nishie; Toshifumi Nomura; Hiroshi Shimizu
The β9 loop domain of PA-PLA1α has a crucial role in autosomal recessive woolly hair/hypotrichosis.
The Journal of investigative dermatology 2012;132(8):2093-5.
2012: Kazuki Kato; Emiko Mihara; Hiroshi Nishimasu; Junken Aoki; Ryuichiro Ishitani; Junichi Takagi; Osamu Nureki
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 7):778-82.
2012: Takanao Sato; Kenji Sugimoto; Junken Aoki; Asuka Inoue; Shinichi Okudaira; Hidetoshi Tokuyama
Synthesis and biological evaluation of optically active Ki16425.
Bioorganic & medicinal chemistry letters 2012;22(13):4323-6.
2012: Akira Sato; Takeshi Kumagai; Junken Aoki; Keiichi Ebina
Synthetic biotinylated peptide compounds derived from Asp-hemolysin: novel potent inhibitors of platelet-activating factor.
European journal of pharmacology 2012;685(1-3):205-12.
2012: Daisuke Saigusa; Masayoshi Saito; Kanako Shiba; Kaori Suzuki; Naoto Suzuki; Hiroaki Yamaguchi; Junken Aoki; Junichi Goto; Kotaro Hama; Takanori Hishinuma; Nagisa Iida; Asuka Inoue; Tohru Kaneko; Nariyasu Mano; Michiyo Okutani; Yoshihisa Tomioka
Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.
Analytical and bioanalytical chemistry 2012;403(7):1897-905.
2012: Hajime Kitamura; Kumiko Makide; Sho Nakamura; Tomohiko Ohwada; Yuko Otani; Yusuke Sato; Akira Shuto; Kensuke Suzuki; Masaya Ikubo; Asuka Inoue; Junken Aoki
GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.
Journal of biochemistry 2012;151(5):511-8.
2012: Shigetomo Fukuhara; Masanori Hirashima; Asuka Inoue; Junji Ishida; Masaru Ishii; Shunsuke Kawamura; Hiroshi Kiyonari; Takaya Abe; Junken Aoki; Yuji Arai; Akiyoshi Fukamizu; Kazumasa Moriwaki; Yasuko Orba; Hirofumi Sawa; Szandor Simmons; Yuji Sunden; Takeshi Tokudome; Akiyoshi Uemura; Naoki Mochizuki
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.
The Journal of clinical investigation 2012;122(4):1416-26.
2012: Hiroshi Nishimasu; Junken Aoki; Ryuichiro Ishitani; Osamu Nureki
A 3D view of autotaxin.
Trends in pharmacological sciences 2012;33(3):138-45.
2012: Naoaki Arima; Asuka Inoue; Kumiko Makide; Takamasa Nonaka; Junken Aoki
Surface loops of extracellular phospholipase A(1) determine both substrate specificity and preference for lysophospholipids.
Journal of lipid research 2012;53(3):513-21.
2012: Toru Uyama; Junken Aoki; Hiroyuki Arai; Nobukazu Araki; Ikuyo Ichi; Asuka Inoue; Xing-Hua Jin; Nozomu Kono; Kazuhito Tsuboi; Natsuo Ueda
Regulation of peroxisomal lipid metabolism by catalytic activity of tumor suppressor H-rev107.
The Journal of biological chemistry 2012;287(4):2706-18.
2011: Shinsuke Kazama; Joji Kitayama; Ken Mori; Junken Aoki; Hirokazu Nagawa
Immunohistochemical detection of autotaxin (ATX)/lysophospholipase D (lysoPLD) in submucosal invasive colorectal cancer.
Journal of gastrointestinal cancer 2011;42(4):204-11.
2011: Asuka Inoue; Jun Ishiguro; Glenn D Prestwich; Hiroyuki Arai; Naoaki Arima; Junken Aoki
LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling.
The EMBO journal 2011;30(20):4248-60.
2011: Akiko Masuda; Kazuhiro Nakamura; Ryunosuke Ohkawa; Shinichi Okudaira; Junken Aoki; Tomoyuki Fujii; Koji Igarashi; Hitoshi Ikeda; Yuki Iwasawa; Shiro Kozuma; Yutaka Yatomi
Serum autotaxin measurements in pregnant women: application for the differentiation of normal pregnancy and pregnancy-induced hypertension.
Clinica chimica acta; international journal of clinical chemistry 2011;412(21-22):1944-50.
2011: Mitsuyasu Kawaguchi; Hirotatsu Kojima; Toru Komatsu; Junken Aoki; Yuuta Fujikawa; Kenjiro Hanaoka; Takayoshi Okabe; Shinichi Okudaira; Takuya Terai; Tetsuo Nagano
Fluorescence probe for lysophospholipase C/NPP6 activity and a potent NPP6 inhibitor.
Journal of the American Chemical Society 2011;133(31):12021-30.
2011: Hayato Nakagawa; Hitoshi Ikeda; Kazuhiro Nakamura; Ryunosuke Ohkawa; Ryota Masuzaki; Ryosuke Tateishi; Haruhiko Yoshida; Naoko Watanabe; Kazuaki Tejima; Yukio Kume; Tomomi Iwai; Atsushi Suzuki; Tomoaki Tomiya; Yukiko Inoue; Takako Nishikawa; Natsuko Ohtomo; Yasushi Tanoue; Masao Omata; Koji Igarashi; Junken Aoki; Kazuhiko Koike; Yutaka Yatomi
Autotaxin as a novel serum marker of liver fibrosis.
Clinica chimica acta; international journal of clinical chemistry 2011;412(13-14):1201-6.
2011: Yousuke Nakai; Hitoshi Ikeda; Kazuhiro Nakamura; Yukio Kume; Mitsuhiro Fujishiro; Naoki Sasahira; Kenji Hirano; Hiroyuki Isayama; Minoru Tada; Takao Kawabe; Yutaka Komatsu; Masao Omata; Junken Aoki; Kazuhiko Koike; Yutaka Yatomi
Specific increase in serum autotaxin activity in patients with pancreatic cancer.
Clinical biochemistry 2011;44(8-9):576-81.
2011: Hiroshi Nishimasu; Shinichi Okudaira; Kotaro Hama; Emiko Mihara; Naoshi Dohmae; Asuka Inoue; Ryuichiro Ishitani; Junichi Takagi; Junken Aoki; Osamu Nureki
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators.
Nature structural & molecular biology 2011;18(2):205-12.
2010: Silvia Cavalli; Anna J S Houben; Harald M H G Albers; Erica W van Tilburg; Arnoud de Ru; Junken Aoki; Peter van Veelen; Wouter H Moolenaar; Huib Ovaa
Development of an activity-based probe for autotaxin.
Chembiochem : a European journal of chemical biology 2010;11(16):2311-7.
2010: Hideyo Ohuchi; Hitomi Fukui; Akane Matsuyo; Sayuri Tomonari; Masayuki Tanaka; Hiroyuki Arai; Sumihare Noji; Junken Aoki
Autotaxin controls caudal diencephalon-mesencephalon development in the chick.
Developmental dynamics : an official publication of the American Association of Anatomists 2010;239(10):2647-58.
2010: Kotaro Hama; Junken Aoki
LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid.
Progress in lipid research 2010;49(4):335-42.
2010: Katsuhiko Takahashi; Naoko Sasabe; Kumiko Ohshima; Keiko Kitazato; Rina Kato; Yutaka Masuda; Mika Tsurumaki; Takashi Obama; Shin-ichi Okudaira; Junken Aoki; Hiroyuki Arai; Tomohiro Yamaguchi; Hiroyuki Itabe
Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver.
Journal of lipid research 2010;51(9):2571-80.
2010: Kazuhiro Nakamura; Koji Igarashi; Ryunosuke Ohkawa; Naoya Saiki; Mika Nagasaki; Kansei Uno; Naoto Hayashi; Tetsuji Sawada; Kenichi Syukuya; Hiromitsu Yokota; Hiroyuki Arai; Hitoshi Ikeda; Junken Aoki; Yutaka Yatomi
A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1) in human serum samples.
Clinica chimica acta; international journal of clinical chemistry 2010;411(15-16):1090-4.
2010: Keita Nakanaga; Kotaro Hama; Junken Aoki
Autotaxin--an LPA producing enzyme with diverse functions.
Journal of biochemistry 2010;148(1):13-24.
2010: Shinichi Okudaira; Hiroshi Yukiura; Junken Aoki
Biological roles of lysophosphatidic acid signaling through its production by autotaxin.
Biochimie 2010;92(6):698-706.
2010: Satoru Shinkuma; Masashi Akiyama; Asuka Inoue; Junken Aoki; Ken Natsuga; Toshifumi Nomura; Ken Arita; Riichiro Abe; Kei Ito; Hideki Nakamura; Hideyuki Ujiie; Akihiko Shibaki; Hiraku Suga; Yuichiro Tsunemi; Wataru Nishie; Hiroshi Shimizu
Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis.
Human mutation 2010;31(5):602-10.
2010: Lin Ma; Hitoshi Uchida; Jun Nagai; Makoto Inoue; Junken Aoki; Hiroshi Ueda
Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain.
The Journal of pharmacology and experimental therapeutics 2010;333(2):540-6.
2010: Kensuke Otani; Joji Kitayama; Koji Yasuda; Yasunori Nio; Masato Iwabu; Shinichi Okudaira; Junken Aoki; Toshimasa Yamauchi; Takashi Kadowaki; Hirokazu Nagawa
Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice.
Cancer letters 2010;288(2):177-82.
2010: Jun Nagai; Hitoshi Uchida; Yosuke Matsushita; Ryo Yano; Mutsumi Ueda; Masami Niwa; Junken Aoki; Jerold Chun; Hiroshi Ueda
Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine.
Molecular pain 2010;6():78.
2010: Hiroyuki Hosono; Masato Homma; Yoko Ogasawara; Kumiko Makide; Junken Aoki; Hideaki Niwata; Machiko Watanabe; Keizo Inoue; Nobuhiro Ohkohchi; Yukinao Kohda
Expression of phosphatidylserine-specific phospholipase A(1) mRNA in human THP-1-derived macrophages.
Cell transplantation 2010;19(6):759-64.
2010: Marion David; Estelle Wannecq; Françoise Descotes; Silvia Jansen; Blandine Deux; Johnny Ribeiro; Claire-Marie Serre; Sandra Grès; Nathalie Bendriss-Vermare; Mathieu Bollen; Simone Saez; Junken Aoki; Jean Sébastien Saulnier-Blache; Philippe Clézardin; Olivier Peyruchaud
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts.
PloS one 2010;5(3):e9741.
2009: Masazumi Iwashita; Kumiko Makide; Taro Nonomura; Yoshimasa Misumi; Yuko Otani; Mayuko Ishida; Ryo Taguchi; Masafumi Tsujimoto; Junken Aoki; Hiroyuki Arai; Tomohiko Ohwada
Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative.
Journal of medicinal chemistry 2009;52(19):5837-63.
2009: Rei K Morikawa; Junken Aoki; Fumi Kano; Masayuki Murata; Akitsugu Yamamoto; Masafumi Tsujimoto; Hiroyuki Arai
Intracellular phospholipase A1gamma (iPLA1gamma) is a novel factor involved in coat protein complex I- and Rab6-independent retrograde transport between the endoplasmic reticulum and the Golgi complex.
The Journal of biological chemistry 2009;284(39):26620-30.
2009: Thorsten Trimbuch; Prateep Beed; Johannes Vogt; Sebastian Schuchmann; Nikolaus Maier; Michael Kintscher; Jörg Breustedt; Markus Schuelke; Nora Streu; Olga Kieselmann; Irene Brunk; Gregor Laube; Ulf Strauss; Arne Battefeld; Hagen Wende; Carmen Birchmeier; Stefan Wiese; Michael Sendtner; Hiroshi Kawabe; Mika Kishimoto-Suga; Nils Brose; Jan Baumgart; Beate Geist; Junken Aoki; Nicolai E Savaskan; Anja U Bräuer; Jerold Chun; Olaf Ninnemann; Dietmar Schmitz; Robert Nitsch
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Cell 2009;138(6):1222-35.
2009: Mohammed Ahmed Abdel Muneem Nouh; Xiu-Xian Wu; Homare Okazoe; Hiroyuki Tsunemori; Reiji Haba; Abdel Muneem Mohammed Abou-Zeid; Mohammed Diaa Saleem; Masashi Inui; Mikio Sugimoto; Junken Aoki; Yoshiyuki Kakehi
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.
Cancer science 2009;100(9):1631-8.
2009: Kumiko Makide; Hajime Kitamura; Yusuke Sato; Michiyo Okutani; Junken Aoki
Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol.
Prostaglandins & other lipid mediators 2009;89(3-4):135-9.
2009: Yuki Iwasawa; Tomoyuki Fujii; Takeshi Nagamatsu; Kei Kawana; Shinichi Okudaira; Shiho Miura; Junko Matsumoto; Ayako Tomio; Hironobu Hyodo; Takahiro Yamashita; Katsutoshi Oda; Shiro Kozuma; Junken Aoki; Yutaka Yatomi; Yuji Taketani
Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta.
American journal of reproductive immunology (New York, N.Y. : 1989) 2009;62(2):90-5.
2009: Tomoko Endo; Kuniyuki Kano; Ryoichi Motoki; Kotaro Hama; Shinichi Okudaira; Mayuko Ishida; Hideo Ogiso; Masayuki Tanaka; Norio Matsuki; Ryo Taguchi; Motomu Kanai; Masakatsu Shibasaki; Hiroyuki Arai; Junken Aoki
Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.
Journal of biochemistry 2009;146(2):283-93.
2009: Kazuhiro Nakamura; Ryunosuke Ohkawa; Shigeo Okubo; Hiromitsu Yokota; Hitoshi Ikeda; Yutaka Yatomi; Koji Igarashi; Kazufumi Ide; Tatsuya Kishimoto; Akiko Masuda; Tomotaka Yamamoto; Shoji Tsuji; Nobuhito Saito; Mineo Kurokawa; Shinichi Okudaira; Junken Aoki
Autotaxin enzyme immunoassay in human cerebrospinal fluid samples.
Clinica chimica acta; international journal of clinical chemistry 2009;405(1-2):160-2.
2009: Lin Ma; Hitoshi Uchida; Jun Nagai; Makoto Inoue; Jerold Chun; Junken Aoki; Hiroshi Ueda
Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.
Molecular pain 2009;5():64.
2009: Kumiko Makide; Kuniyuki Kano; Hajime Kitamura; Naoaki Arima; Junken Aoki
[Lysophospholipid mediators].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2009;54(1):29-39.
2008: Hideyo Ohuchi; Aska Hamada; Hironao Matsuda; Akira Takagi; Masayuki Tanaka; Junken Aoki; Hiroyuki Arai; Sumihare Noji
Expression patterns of the lysophospholipid receptor genes during mouse early development.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(11):3280-94.
2008: Tae Nakasaki; Toshiyuki Tanaka; Shinichi Okudaira; Michi Hirosawa; Eiji Umemoto; Kazuhiro Otani; Soojung Jin; Zhongbin Bai; Haruko Hayasaka; Yoshinori Fukui; Katsuyuki Aozasa; Naoya Fujita; Takashi Tsuruo; Keiichi Ozono; Junken Aoki; Masayuki Miyasaka
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions.
The American journal of pathology 2008;173(5):1566-76.
2008: Akiko Masuda; Kazuhiro Nakamura; Koji Izutsu; Koji Igarashi; Ryunosuke Ohkawa; Masahiro Jona; Katsumi Higashi; Hiromitsu Yokota; Shinichi Okudaira; Tatsuya Kishimoto; Takuro Watanabe; Yukako Koike; Hitoshi Ikeda; Yasushi Kozai; Mineo Kurokawa; Junken Aoki; Yutaka Yatomi
Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma.
British journal of haematology 2008;143(1):60-70.
2008: Junken Aoki; Asuka Inoue; Shinichi Okudaira
Two pathways for lysophosphatidic acid production.
Biochimica et biophysica acta 2008;1781(9):513-8.
2008: Takahiro Kanamori; Takao Inoue; Taro Sakamoto; Keiko Gengyo-Ando; Masafumi Tsujimoto; Shohei Mitani; Hitoshi Sawa; Junken Aoki; Hiroyuki Arai
Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions.
The EMBO journal 2008;27(12):1647-57.
2008: Makoto Inoue; W Xie; Y Matsushita; Jerold Chun; Junken Aoki; Hiroshi Ueda
Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.
Neuroscience 2008;152(2):296-8.
2008: Kazuhiro Nakamura; Koji Igarashi; Kazufumi Ide; Ryunosuke Ohkawa; Shigeo Okubo; Hiromitsu Yokota; Akiko Masuda; Noriko Oshima; Takumi Takeuchi; Masaomi Nangaku; Shinichi Okudaira; Hiroyuki Arai; Hitoshi Ikeda; Junken Aoki; Yutaka Yatomi
Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation.
Clinica chimica acta; international journal of clinical chemistry 2008;388(1-2):51-8.
2008: Nozomu Kono; Takao Inoue; Yasukazu Yoshida; Hiroyuki Sato; Tomokazu Matsusue; Hiroyuki Itabe; Etsuo Niki; Junken Aoki; Hiroyuki Arai
Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo.
The Journal of biological chemistry 2008;283(3):1628-36.
2008: Kuniyuki Kano; Naoaki Arima; Mitsuru Ohgami; Junken Aoki
LPA and its analogs-attractive tools for elucidation of LPA biology and drug development.
Current medicinal chemistry 2008;15(21):2122-31.
2008: Makoto Inoue; Lin Ma; Junken Aoki; Jerold Chun; Hiroshi Ueda
Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.
Molecular pain 2008;4():6.
2008: Kazuhiro Nakamura; Masaomi Nangaku; Ryunosuke Ohkawa; Shigeo Okubo; Hiromitsu Yokota; Hitoshi Ikeda; Junken Aoki; Yutaka Yatomi
Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(1):150-1.
2007: Kotaro Hama; Junken Aoki; Asuka Inoue; Tomoko Endo; Tomokazu Amano; Rie Motoki; Motomu Kanai; Xiaoqin Ye; Jerold Chun; Norio Matsuki; Hiroshi Suzuki; Masakatsu Shibasaki; Hiroyuki Arai
Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice.
Biology of reproduction 2007;77(6):954-9.
2007: Kazuhiro Nakamura; Takumi Takeuchi; Ryunosuke Ohkawa; Shigeo Okubo; Hiromitsu Yokota; Minoru Tozuka; Junken Aoki; Hiroyuki Arai; Hitoshi Ikeda; Noriko Ohshima; Tadaichi Kitamura; Yutaka Yatomi
Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients.
Annals of clinical biochemistry 2007;44(Pt 6):549-56.
2007: Noritaka Yamaguchi; Hiroyuki Koizumi; Junken Aoki; Yasuhiro Natori; Kiyotaka Nishikawa; Yasuhiro Natori; Yasukazu Takanezawa; Hiroyuki Arai
Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(10):1153-61.
2007: Naoko Watanabe; Hitoshi Ikeda; Kazuhiro Nakamura; Ryunosuke Ohkawa; Yukio Kume; Tomoaki Tomiya; Kazuaki Tejima; Takako Nishikawa; Masahiro Arai; Mikio Yanase; Junken Aoki; Hiroyuki Arai; Masao Omata; Kenji Fujiwara; Yutaka Yatomi
Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity.
Life sciences 2007;81(12):1009-15.
2007: Naoko Watanabe; Hitoshi Ikeda; Kazuhiro Nakamura; Ryunosuke Ohkawa; Yukio Kume; Junken Aoki; Kotaro Hama; Shinichi Okudaira; Masayuki Tanaka; Tomoaki Tomiya; Mikio Yanase; Kazuaki Tejima; Takako Nishikawa; Masahiro Arai; Hiroyuki Arai; Masao Omata; Kenji Fujiwara; Yutaka Yatomi
Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.
Journal of clinical gastroenterology 2007;41(6):616-23.
2007: Ken Mori; Joji Kitayama; Junken Aoki; Yasuhiro Kishi; Dai Shida; Hiroharu Yamashita; Hiroyuki Arai; Hirokazu Nagawa
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD).
Virchows Archiv : an international journal of pathology 2007;451(1):47-56.
2007: Yumiko Satoh; Ryunosuke Ohkawa; Kazuhiro Nakamura; Katsumi Higashi; Makoto Kaneko; Hiromitsu Yokota; Junken Aoki; Hiroyuki Arai; Yasuhito Yuasa; Yutaka Yatomi
Lysophosphatidic acid protection against apoptosis in the human pre-B-cell line Nalm-6.
European journal of haematology 2007;78(6):510-7.
2007: Akira Tokumura; Tetsuya Kume; Kenji Fukuzawa; Masahiro Tahara; Keiichi Tasaka; Junken Aoki; Hiroyuki Arai; Katsuhiko Yasuda; Hideharu Kanzaki
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Life sciences 2007;80(18):1641-9.
2007: Hideyo Ohuchi; Yasunori Hayashibara; Yasunori Hayashibaral; Hironao Matsuda; Motoyoshi Onoi; Masayuki Mitsumori; Masayuki Tanaka; Junken Aoki; Hiroyuki Arai; Sumihare Noji
Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(4):1134-43.
2007: Kimiko Umemura; Ichiro Kato; Yutaka Hirashima; Yoko Ishii; Takao Inoue; Junken Aoki; Nozomu Kono; Takeshi Oya; Nakamasa Hayashi; Hideo Hamada; Shunro Endo; Masaya Oda; Hiroyuki Arai; Hiroyuki Kinouchi; Koichi Hiraga
Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2007;38(3):1063-8.
2007: Kazuhiro Nakamura; Ryunosuke Ohkawa; Shigeo Okubo; Minoru Tozuka; Mitsumasa Okada; Shinya Aoki; Junken Aoki; Hiroyuki Arai; Hitoshi Ikeda; Yutaka Yatomi
Measurement of lysophospholipase D/autotaxin activity in human serum samples.
Clinical biochemistry 2007;40(3-4):274-7.
2007: Junken Aoki; Asuka Inoue; Kumiko Makide; Naoya Saiki; Hiroyuki Arai
Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family.
Biochimie 2007;89(2):197-204.
2007: Rei Morikawa; Masafumi Tsujimoto; Hiroyuki Arai; Junken Aoki
Phospholipase A(1) assays using a radiolabeled substrate and mass spectrometry.
Methods in enzymology 2007;434():1-13.
2006: Mitsuhiro Ohtsuki; Yoshitaka Taketomi; Satoru Arata; Seiko Masuda; Yukio Ishikawa; Toshiharu Ishii; Yasukazu Takanezawa; Junken Aoki; Hiroyuki Arai; Kei Yamamoto; Ichiro Kudo; Makoto Murakami
Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction.
The Journal of biological chemistry 2006;281(47):36420-33.
2006: Kotaro Hama; Junken Aoki; Koji Bandoh; Asuka Inoue; Tomoko Endo; Tomokazu Amano; Hiroshi Suzuki; Hiroyuki Arai
Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus.
Life sciences 2006;79(18):1736-40.
2006: Satomi Tsuda; Shinichi Okudaira; Keiko Moriya-Ito; Chie Shimamoto; Masayuki Tanaka; Junken Aoki; Hiroyuki Arai; Kimiko Murakami-Murofushi; Tetsuyuki Kobayashi
Cyclic phosphatidic acid is produced by autotaxin in blood.
The Journal of biological chemistry 2006;281(36):26081-8.
2006: Masayuki Tanaka; Shinichi Okudaira; Yasuhiro Kishi; Ryunosuke Ohkawa; Sachiko Iseki; Masato Ota; Sumihare Noji; Yutaka Yatomi; Junken Aoki; Hiroyuki Arai
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.
The Journal of biological chemistry 2006;281(35):25822-30.
2006: Hiroaki Okazaki; Masaki Igarashi; Makiko Nishi; Makiko Tajima; Motohiro Sekiya; Sachiko Okazaki; Naoya Yahagi; Ken Ohashi; Kazuhisa Tsukamoto; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Hitoshi Shimano; Nobuhiro Yamada; Junken Aoki; Rei Morikawa; Yasukazu Takanezawa; Hiroyuki Arai; Ryozo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis.
Diabetes 2006;55(7):2091-7.
2006: Yasuhiro Kishi; Shinichi Okudaira; Masayuki Tanaka; Kotaro Hama; Dai Shida; Joji Kitayama; Takao Yamori; Junken Aoki; Takamitsu Fujimaki; Hiroyuki Arai
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.
The Journal of biological chemistry 2006;281(25):17492-500.
2006: Nobuo Watanabe; Jaroslaw W Zmijewski; Wakako Takabe; Makiko Umezu-Goto; Claire Le Goffe; Azusa Sekine; Aimee Landar; Akira Watanabe; Junken Aoki; Hiroyuki Arai; Tatsuhiko Kodama; Michael P Murphy; Raman Kalyanaraman; Victor Darley-Usmar; Noriko Noguchi
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells.
The American journal of pathology 2006;168(5):1737-48.
2006: Lian Qian; Yong Xu; Ted Simper; Guowei Jiang; Junken Aoki; Makiko Umezu-Goto; Hiroyuki Arai; Shuangxing Yu; Gordon B Mills; Ryoko Tsukahara; Natalia Makarova; Yuko Fujiwara; Gabor Tigyi; Glenn D Prestwich
Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists.
ChemMedChem 2006;1(3):376-83.
2006: Hiroharu Yamashita; Joji Kitayama; Dai Shida; Makoto Ishikawa; Kotaro Hama; Junken Aoki; Hiroyuki Arai; Hirokazu Nagawa
Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer.
Journal of surgical oncology 2006;93(1):30-5.
2006: Yutaka Masuda; Hiroyuki Itabe; Miho Odaki; Kotaro Hama; Yasuyuki Fujimoto; Masahiro Mori; Naoko Sasabe; Junken Aoki; Hiroyuki Arai; Tatsuya Takano
ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells.
Journal of lipid research 2006;47(1):87-98.
2005: Karl Baumforth; Joanne R Flavell; Gary M Reynolds; Gillian Davies; Trevor R Pettit; wenbin Wei; Susan Morgan; Tatjana Stankovic; Yasuhiro Kishi; Hiroyuki Arai; Marketa Nowakova; Guy Pratt; Junken Aoki; Michael J O Wakelam; Lawrence S Young; Paul G Murray
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells.
Blood 2005;106(6):2138-46.
2005: Hideki Sakagami; Junken Aoki; Yumiko Natori; Kiyotaka Nishikawa; Yoshiyuki Kakehi; Yasuhiro Natori; Hiroyuki Arai
Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
The Journal of biological chemistry 2005;280(24):23084-93.
2005: Seiko Masuda; Makoto Murakami; Yasukazu Takanezawa; Junken Aoki; Hiroyuki Arai; Yukio Ishikawa; Toshiharu Ishii; Manabu Arioka; Ichiro Kudo
Neuronal expression and neuritogenic action of group X secreted phospholipase A2.
The Journal of biological chemistry 2005;280(24):23203-14.
2005: Xiaoqin Ye; Kotaro Hama; James J A Contos; Brigitte Anliker; Asuka Inoue; Michael Skinner; Hiroshi Suzuki; Tomokazu Amano; Grace Kennedy; Hiroyuki Arai; Junken Aoki; Jerold Chun
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing.
Nature 2005;435(7038):104-8.
2005: Yong Xu; Junken Aoki; Kumiko Shimizu; Makiko Umezu-Goto; Kotaro Hama; Yasukazu Takanezawa; Shuangxing Yu; Gordon B Mills; Hiroyuki Arai; Lian Qian; Glenn D Prestwich
Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Journal of medicinal chemistry 2005;48(9):3319-27.
2005: Makoto Murakami; Seiko Masuda; Kaori Ueda-Semmyo; Emiko Yoda; Hiroshi Kuwata; Yasukazu Takanezawa; Junken Aoki; Hiroyuki Arai; Hideki Sumimoto; Yukio Ishikawa; Toshiharu Ishii; Yoshihito Nakatani; Ichiro Kudo
Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2.
The Journal of biological chemistry 2005;280(14):14028-41.
2004: Dai Shida; Joji Kitayama; Hironori Yamaguchi; Kotaro Hama; Junken Aoki; Hiroyuki Arai; Hiroharu Yamashita; Ken Mori; Akihiro Sako; Tsuyoshi Konishi; Toshiaki Watanabe; Teruyuki Sakai; Rika Suzuki; Hideo Ohta; Yoh Takuwa; Hirokazu Nagawa
Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.
Experimental cell research 2004;301(2):168-78.
2004: Yong Xu; Masayuki Tanaka; Hiroyuki Arai; Junken Aoki; Glenn D Prestwich
Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors.
Bioorganic & medicinal chemistry letters 2004;14(21):5323-8.
2004: Junken Aoki
Mechanisms of lysophosphatidic acid production.
Seminars in cell & developmental biology 2004;15(5):477-89.
2004: Dai Shida; Toshiaki Watanabe; Junken Aoki; Kotaro Hama; Joji Kitayama; Hirofumi Sonoda; Yasuhiro Kishi; Hironori Yamaguchi; Shin Sasaki; Akihiro Sako; Tsuyoshi Konishi; Hiroyuki Arai; Hirokazu Nagawa
Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer.
Laboratory investigation; a journal of technical methods and pathology 2004;84(10):1352-62.
2004: Takao Inoue; Asako Sugimoto; Yuka Suzuki; Masayuki Yamamoto; Masafumi Tsujimoto; Keizo Inoue; Junken Aoki; Hiroyuki Arai
Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13233-8.
2004: Masayuki Tanaka; Yasuhiro Kishi; Yasukazu Takanezawa; Yoshiyuki Kakehi; Junken Aoki; Hiroyuki Arai
Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma.
FEBS letters 2004;571(1-3):197-204.
2004: Noritaka Yamaguchi; Yasukazu Takanezawa; Hiroyuki Koizumi; Makiko Umezu-Goto; Junken Aoki; Hiroyuki Arai
Expression of NUDEL in manchette and its implication in spermatogenesis.
FEBS letters 2004;566(1-3):71-6.
2004: Yoko Tamaruya; Masato Suzuki; Goshu Kamura; Motomu Kanai; Kotaro Hama; Kumiko Shimizu; Junken Aoki; Hiroyuki Arai; Masakatsu Shibasaki
Identifying specific conformations by using a carbohydrate scaffold: discovery of subtype-selective LPA-receptor agonists and an antagonist.
Angewandte Chemie (International ed. in English) 2004;43(21):2834-7.
2004: Kotaro Hama; Junken Aoki; MASAHIRO FUKAYA; Yasuhiro Kishi; Teruyuki Sakai; Rika Suzuki; Hideo Ohta; Takao Yamori; Masahiko Watanabe; Jerold Chun; Hiroyuki Arai
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
The Journal of biological chemistry 2004;279(17):17634-9.
2004: Joji Kitayama; Dai Shida; Akihiro Sako; Makoto Ishikawa; Kotaro Hama; Junken Aoki; Hiroyuki Arai; Hirokazu Nagawa
Over-expression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma.
Breast cancer research : BCR 2004;6(6):R640-6.
2003: Lian Qian; Yong Xu; Yutaka Hasegawa; Junken Aoki; Gordon B Mills; Glenn D Prestwich
Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
Journal of medicinal chemistry 2003;46(26):5575-8.
2003: Tatsufumi Hiramatsu; Hirofumi Sonoda; Yasukazu Takanezawa; Rei Morikawa; Mayuko Ishida; Kohji Kasahara; Yutaka Sanai; Ryo Taguchi; Junken Aoki; Hiroyuki Arai
Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta.
The Journal of biological chemistry 2003;278(49):49438-47.
2003: Lian Qian; Yong Xu; Hiroyuki Arai; Junken Aoki; Thomas M McIntyre; Glenn D Prestwich
Synthesis of migration-resistant hydroxyethoxy analogues of lysophosphatidic acid.
Organic letters 2003;5(24):4685-8.
2003: Kenji Yoshida; Wataru Nishida; Ken'ichiro Hayashi; Yasuyuki Ohkawa; Akira Ogawa; Junken Aoki; Hiroyuki Arai; Kenji Sobue
Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo.
Circulation 2003;108(14):1746-52.
2003: Michal Caspi; Frédéric Coquelle; Cynthia Koifman; Talia Levy; Hiroyuki Arai; Junken Aoki; Jan R De Mey; Orly Reiner
LIS1 missense mutations: variable phenotypes result from unpredictable alterations in biochemical and cellular properties.
The Journal of biological chemistry 2003;278(40):38740-8.
2003: Timothy Clair; Junken Aoki; Eunjin Koh; Russell W Bandle; Suk Woo Nam; Malgorzata M Ptaszynska; Gordon B Mills; Elliott Schiffmann; Lance A Liotta; Mary L Stracke
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Cancer research 2003;63(17):5446-53.
2003: Junken Aoki
[Mechanism of lysophosphatidic acid production].
Seikagaku. The Journal of Japanese Biochemical Society 2003;75(7):609-13.
2003: Daisy E Kaempf-Rotzoll; M Horiguchi; K Hashiguchi; Junken Aoki; H Tamai; Otwin Linderkamp; Hiroyuki Arai
Human placental trophoblast cells express alpha-tocopherol transfer protein.
Placenta 2003;24(5):439-44.
2003: Yutaka Hasegawa; James R Erickson; Graham J Goddard; Shuangxing Yu; Shuying Liu; Kwai Wa Cheng; Astrid Eder; Koji Bandoh; Junken Aoki; Renata Jarosz; Andrew D Schrier; Kevin R Lynch; Gordon B Mills; Xianjun Fang
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
The Journal of biological chemistry 2003;278(14):11962-9.
2003: Hiroyuki Koizumi; Noritaka Yamaguchi; Mitsuharu Hattori; Tomo-O Ishikawa; Junken Aoki; Makoto M Taketo; Keizo Inoue; Hiroyuki Arai
Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis.
The Journal of biological chemistry 2003;278(14):12489-94.
2003: Rik Gijsbers; Junken Aoki; Hiroyuki Arai; Mathieu Bollen
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site.
FEBS letters 2003;538(1-3):60-4.
2003: Thomas M McIntyre; Aaron V Pontsler; Adriana R Silva; Andy St Hilaire; Yong Xu; Jerald C Hinshaw; Guy A Zimmerman; Kotaro Hama; Junken Aoki; Hiroyuki Arai; Glenn D Prestwich
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):131-6.
2002: Junken Aoki; Akitsu Taira; Yasukazu Takanezawa; Yasuhiro Kishi; Kotaro Hama; Tatsuya Kishimoto; Koji Mizuno; Keijiro Saku; Ryo Taguchi; Hiroyuki Arai
Serum lysophosphatidic acid is produced through diverse phospholipase pathways.
The Journal of biological chemistry 2002;277(50):48737-44.
2002: Junko Ishii; Hideki Adachi; Junken Aoki; Hiroyuki Koizumi; Susumu Tomita; Toshiharu Suzuki; Masafumi Tsujimoto; Keizo Inoue; Hiroyuki Arai
SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain.
The Journal of biological chemistry 2002;277(42):39696-702.
2002: Tomomi Watanabe; Kentaro Nakagawa; Shinya Ohata; Daiju Kitagawa; Gen Nishitai; Jungwon Seo; Shuhei Tanemura; Nao Shimizu; Hiroyuki Kishimoto; Teiji Wada; Junken Aoki; Hiroyuki Arai; Takeshi Iwatsubo; Miyuki Mochita; Toshio Watanabe; Masanobu Satake; Yoshiaki Ito; Toshifumi Matsuyama; Tak W Mak; Josef M Penninger; Hiroshi Nishina; Toshiaki Katada
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Developmental biology 2002;250(2):332-47.
2002: Mariangela Marques; Yong Pei; Michael D Southall; John M Johnston; Hiroyuki Arai; Junken Aoki; Takao Inoue; Holger Seltmann; Christos Zouboulis; Jeffrey B Travers
Identification of platelet-activating factor acetylhydrolase II in human skin.
The Journal of investigative dermatology 2002;119(4):913-9.
2002: Hirofumi Sonoda; Junken Aoki; Tatsufumi Hiramatsu; Mayuko Ishida; Koji Bandoh; Yuki Nagai; Ryo Taguchi; Keizo Inoue; Hiroyuki Arai
A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid.
The Journal of biological chemistry 2002;277(37):34254-63.
2002: Daisy E Kaempf-Rotzoll; K Igarashi; Junken Aoki; Kou-ichi Jishage; Hiroshi Suzuki; H Tamai; Otwin Linderkamp; Hiroyuki Arai
Alpha-tocopherol transfer protein is specifically localized at the implantation site of pregnant mouse uterus.
Biology of reproduction 2002;67(2):599-604.
2002: Makiko Umezu-Goto; Yasuhiro Kishi; Akitsu Taira; Kotaro Hama; Naoshi Dohmae; Koji Takio; Takao Yamori; Gordon B Mills; Keizo Inoue; Junken Aoki; Hiroyuki Arai
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
The Journal of cell biology 2002;158(2):227-33.
2002: Kotaro Hama; Koji Bandoh; Yoshiyuki Kakehi; Junken Aoki; Hiroyuki Arai
Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.
FEBS letters 2002;523(1-3):187-92.
2002: Keiko Kawamoto; Junken Aoki; Akane Tanaka; Atsuko Itakura; Hiroyuki Hosono; Hiroyuki Arai; Yasuo Kiso; Hiroshi Matsuda
Nerve growth factor activates mast cells through the collaborative interaction with lysophosphatidylserine expressed on the membrane surface of activated platelets.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6412-9.
2002: Kiyotaka Nishikawa; Koji Matsuoka; Eiji Kita; Noriko Okabe; Masashi Mizuguchi; Kumiko Hino; Shinobu Miyazawa; Chisato Yamasaki; Junken Aoki; Sachio Takashima; Yoshio Yamakawa; Masahiro Nishijima; Daiyo Terunuma; Hiroyoshi Kuzuhara; Yasuhiro Natori
A therapeutic agent with oriented carbohydrates for treatment of infections by Shiga toxin-producing Escherichia coli O157:H7.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7669-74.
2002: Junken Aoki; Yuki Nagai; Hiroyuki Hosono; Keizo Inoue; Hiroyuki Arai
Structure and function of phosphatidylserine-specific phospholipase A1.
Biochimica et biophysica acta 2002;1582(1-3):26-32.
2002: Hiroyuki Arai; Hiroyuki Koizumi; Junken Aoki; Keizo Inoue
Platelet-activating factor acetylhydrolase (PAF-AH).
Journal of biochemistry 2002;131(5):635-40.
2002: Ken-ichi Nakajima; Hirofumi Sonoda; Toshihide Mizoguchi; Junken Aoki; Hiroyuki Arai; Masami Nagahama; Mitsuo Tagaya; Katsuko Tani
A novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125.
The Journal of biological chemistry 2002;277(13):11329-35.
2002: Gordon B Mills; Astrid Eder; Xianjun Fang; Yutaka Hasegawa; Muling Mao; Yiling Lu; Janos L Tanyi; Fazal H Tabassam; Jon R Wiener; Ruth Lapushin; Shiangxing Yu; Jeff A Parrott; Tim Compton; Walter Tribley; David Fishman; M Sharon Stack; Douglas Gaudette; Robert Jaffe; Tatsuro Furui; Junken Aoki; James R Erickson
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Cancer treatment and research 2002;107():259-83.
2001: Hiroyuki Hosono; Junken Aoki; Yuki Nagai; Koji Bandoh; Mayuko Ishida; Ryo Taguchi; Hiroyuki Arai; Kenji Inoue
Phosphatidylserine-specific phospholipase A1 stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lysophosphatidylserine.
The Journal of biological chemistry 2001;276(32):29664-70.
2001: Ken'ichiro Hayashi; Masahiko Takahashi; Wataru Nishida; Kenji Yoshida; Yasuyuki Ohkawa; Akira Kitabatake; Junken Aoki; Hiroyuki Arai; Kenji Sobue
Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids.
Circulation research 2001;89(3):251-8.
2001: James R Erickson; Yutaka Hasegawa; Xiang Fang; Astrid Eder; Muling Mao; Tatsuro Furui; Junken Aoki; Andrew J Morris; Gordon B Mills
Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management.
Prostaglandins & other lipid mediators 2001;64(1-4):63-81.
2000: T W McMullen; J Li; Peter J Sheffield; Junken Aoki; TW Martin; Hiroyuki Arai; K Inoue; Zygmunt S Derewenda
The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib).
Protein engineering 2000;13(12):865-71.
2000: K Bae; Lara Longobardi; Ken Karasawa; B Malone; Takafumi Inoue; Junken Aoki; Hiroyuki Arai; Kenji Inoue; Ten-ching Lee
Platelet-activating factor (PAF)-dependent transacetylase and its relationship with PAF acetylhydrolases.
The Journal of biological chemistry 2000;275(35):26704-9.
2000: M Kitagawa; M Umezu; Junken Aoki; Hiroyuki Koizumi; Hiroyuki Arai; Kenji Inoue
Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE.
FEBS letters 2000;479(1-2):57-62.
2000: Koji Bandoh; Junken Aoki; Akitsu Taira; Masafumi Tsujimoto; Hiroyuki Arai; Kenji Inoue
Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors.
FEBS letters 2000;478(1-2):159-65.
2000: Mamoru Ikemoto; Hiroyuki Arai; D Feng; Keiichi Tanaka; Junken Aoki; Naoshi Dohmae; Koji Takio; Hideki Adachi; Masafumi Tsujimoto; Keizo Inoue
Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6538-43.
2000: Astrid Eder; T Sasagawa; Muling Mao; Junken Aoki; Gordon B Mills
Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2482-91.
2000: Junken Aoki; Koji Bandoh; Kenji Inoue
A novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid with unsaturated fatty-acid moiety.
Annals of the New York Academy of Sciences 2000;905():263-6.
2000: Peter J Sheffield; Sarah M Garrard; Michal Caspi; Junken Aoki; Hiroyuki Arai; Urszula Derewenda; K Inoue; B Suter; Orly Reiner; Zygmunt S Derewenda
Homologs of the alpha- and beta-subunits of mammalian brain platelet-activating factor acetylhydrolase Ib in the Drosophila melanogaster genome.
Proteins 2000;39(1):1-8.
1999: Tamar Sapir; M Eisenstein; Harold A Burgess; D Horesh; A Cahana; Junken Aoki; M Hattori; Hiroyuki Arai; K Inoue; Orly Reiner
Analysis of lissencephaly-causing LIS1 mutations.
European journal of biochemistry / FEBS 1999;266(3):1011-20.
1999: H Manya; Junken Aoki; Hidehito Kato; Junko Ishii; S Hino; Hiroyuki Arai; Kenji Inoue
Biochemical characterization of various catalytic complexes of the brain platelet-activating factor acetylhydrolase.
The Journal of biological chemistry 1999;274(45):31827-32.
1999: Koji Bandoh; Junken Aoki; Hiroyuki Hosono; Susumu Kobayashi; Tetsuyuki Kobayashi; Kimiko Murakami-Murofushi; Masafumi Tsujimoto; Hiroyuki Arai; Kenji Inoue
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid.
The Journal of biological chemistry 1999;274(39):27776-85.
1999: YS Ho; Peter J Sheffield; J Masuyama; Hiroyuki Arai; J Li; Junken Aoki; K Inoue; Urszula Derewenda; Zygmunt S Derewenda
Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase.
Protein engineering 1999;12(8):693-700.
1999: Junken Aoki
[Structure and function of phosphatidylserine-specific phospholipase A1: PS-PLA1].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(8 Suppl):1038-42.
1999: Yuki Nagai; Junken Aoki; Taku Sato; K Amano; Y Matsuda; Hiroyuki Arai; Kenji Inoue
An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans.
The Journal of biological chemistry 1999;274(16):11053-9.
1998: A Hosomi; K Goto; Hisatake Kondo; Takeshi Iwatsubo; Takanori Yokota; M Ogawa; M Arita; Junken Aoki; Hiroyuki Arai; Kenji Inoue
Localization of alpha-tocopherol transfer protein in rat brain.
Neuroscience letters 1998;256(3):159-62.
1998: H Manya; Junken Aoki; Masahiko Watanabe; Takahiro Adachi; Hiroaki Asou; Yorinao Inoue; Hiroyuki Arai; Kenji Inoue
Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain.
The Journal of biological chemistry 1998;273(29):18567-72.
1998: Y Wei; L Swenson; C Castro; Urszula Derewenda; Wladek Minor; Hiroyuki Arai; Junken Aoki; K Inoue; L Servin-Gonzalez; Zygmunt S Derewenda
Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution.
Structure (London, England : 1993) 1998;6(4):511-9.
1998: Masahiko Watanabe; Junken Aoki; H Manya; Hiroyuki Arai; Kenji Inoue
Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase.
Biochimica et biophysica acta 1998;1401(1):73-9.
1997: Atsushi Matsuzawa; K Hattori; Junken Aoki; Hiroyuki Arai; Kenji Inoue
Protection against oxidative stress-induced cell death by intracellular platelet-activating factor-acetylhydrolase II.
The Journal of biological chemistry 1997;272(51):32315-20.
1997: Takahiro Adachi; Junken Aoki; H Manya; Hiroaki Asou; Hiroyuki Arai; Kenji Inoue
PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells.
Neuroscience letters 1997;235(3):133-6.
1997: Taku Sato; Junken Aoki; Yuki Nagai; Naoshi Dohmae; Koji Takio; T Doi; Hiroyuki Arai; Kenji Inoue
Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family.
The Journal of biological chemistry 1997;272(4):2192-8.
1997: YS Ho; L Swenson; Urszula Derewenda; L Serre; Y Wei; Z Dauter; M Hattori; T Adachi; Junken Aoki; Hiroyuki Arai; K Inoue; Zygmunt S Derewenda
Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer.
Nature 1997;385(6611):89-93.
1996: K Hattori; Hideki Adachi; A Matsuzawa; K Yamamoto; M Tsujimoto; Junken Aoki; M Hattori; Hiroyuki Arai; K Inoue
cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase.
The Journal of biological chemistry 1996;271(51):33032-8.
1996: M Hattori; Junken Aoki; Hiroyuki Arai; K Inoue
PAF and PAF acetylhydrolase in the nervous system.
Journal of lipid mediators and cell signalling 1996;14(1-3):99-102.
1995: M Hattori; Hideki Adachi; Junken Aoki; M Tsujimoto; Hiroyuki Arai; K Inoue
Cloning and expression of a cDNA encoding the beta-subunit (30-kDa subunit) of bovine brain platelet-activating factor acetylhydrolase.
The Journal of biological chemistry 1995;270(52):31345-52.
1994: F Reza; K Igarashi; S Tokita; K Asai; Junken Aoki; Y Asaoka; M Umeda; K Inoue
Anti-idiotypic monoclonal antibody recognizes a consensus recognition site for phosphatidylserine in phosphatidylserine-specific monoclonal antibody and protein kinase C.
FEBS letters 1994;339(3):229-33.
1992: Junken Aoki; M Umeda
[Neural cell adhesion molecule: structure and function].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1992;37(11 Suppl):1759-67.
1991: Junken Aoki; M Umeda; K Takio; K Titani; H Utsumi; M Sasaki; K Inoue
Neural cell adhesion molecule mediates contact-dependent inhibition of growth of near-diploid mouse fibroblast cell line m5S/1M.
The Journal of cell biology 1991;115(6):1751-61.