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Junken Aoki
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65
Arai, Hiroyuki
16
Hama, Kotaro
14
Inoue, Kenji
10
Takanezawa, Yasukazu
10
Yatomi, Yutaka
9
Ohkawa, Ryunosuke
9
Okudaira, Shinichi
9
Mills, Gordon
8
Kishi, Yasuhiro
8
Nakamura, Kazuhiro
8
Tsujimoto, Masafumi
7
Inoue, Keizo
7
Ikeda, Hitoshi
7
Arai, Hiroyuki
7
Bandoh, Koji
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All Publications
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2009: Iwashita Masazumi; Makide Kumiko; Nonomura Taro; Misumi Yoshimasa; Otani Yuko; Ishida Mayuko; Taguchi Ryo; Tsujimoto Masafumi; Aoki Junken; Arai Hiroyuki; Ohwada Tomohiko
Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative.
Journal of medicinal chemistry 2009;52(19):5837-63.
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2009: Trimbuch Thorsten; Beed Prateep; Vogt Johannes; Schuchmann Sebastian; Maier Nikolaus; Kintscher Michael; Breustedt Jörg; Schuelke Markus; Streu Nora; Kieselmann Olga; Brunk Irene; Laube Gregor; Strauss Ulf; Battefeld Arne; Wende Hagen; Birchmeier Carmen; Wiese Stefan; Sendtner Michael; Kawabe Hiroshi; Kishimoto-Suga Mika; Brose Nils; Baumgart Jan; Geist Beate; Aoki Junken; Savaskan Nic E; Bräuer Anja U; Chun Jerold; Ninnemann Olaf; Schmitz Dietmar; Nitsch Robert
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Cell 2009;138(6):1222-35.
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2009: Morikawa Rei K; Aoki Junken; Kano Fumi; Murata Masayuki; Yamamoto Akitsugu; Tsujimoto Masafumi; Arai Hiroyuki
Intracellular phospholipase A1gamma (iPLA1gamma) is a novel factor involved in coat protein complex I- and Rab6-independent retrograde transport between the endoplasmic reticulum and the Golgi complex.
The Journal of biological chemistry 2009;284(39):26620-30.
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2009: Nouh Mohammed Ahmed Abdel Muneem; Wu Xiu-Xian; Okazoe Homare; Tsunemori Hiroyuki; Haba Reiji; Abou-Zeid Abdel Muneem Mohammed; Saleem Mohammed Diaa; Inui Masashi; Sugimoto Mikio; Aoki Junken; Kakehi Yoshiyuki
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.
Cancer science 2009;100(9):1631-8.
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2009: Makide Kumiko; Kitamura Hajime; Sato Yusuke; Okutani Michiyo; Aoki Junken
Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol.
Prostaglandins & other lipid mediators 2009;89(3-4):135-9.
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2009: Iwasawa Yuki; Fujii Tomoyuki; Nagamatsu Takeshi; Kawana Kei; Okudaira Shinichi; Miura Shiho; Matsumoto Junko; Tomio Ayako; Hyodo Hironobu; Yamashita Takahiro; Oda Katsutoshi; Kozuma Shiro; Aoki Junken; Yatomi Yutaka; Taketani Yuji
Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta.
American journal of reproductive immunology (New York, N.Y. : 1989) 2009;62(2):90-5.
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2009: Endo Tomoko; Kano Kuniyuki; Motoki Rie; Hama Kotaro; Okudaira Shinichi; Ishida Mayuko; Ogiso Hideo; Tanaka Masayuki; Matsuki Norio; Taguchi Ryo; Kanai Motomu; Shibasaki Masakatsu; Arai Hiroyuki; Aoki Junken
Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.
Journal of biochemistry 2009;146(2):283-93.
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2009: Nakamura Kazuhiro; Ohkawa Ryunosuke; Okubo Shigeo; Yokota Hiromitsu; Ikeda Hitoshi; Yatomi Yutaka; Igarashi Koji; Ide Kazufumi; Kishimoto Tatsuya; Masuda Akiko; Yamamoto Tomotaka; Tsuji Shoji; Saito Nobuhito; Kurokawa Mineo; Okudaira Shinichi; Aoki Junken
Autotaxin enzyme immunoassay in human cerebrospinal fluid samples.
Clinica chimica acta; international journal of clinical chemistry 2009;405(1-2):160-2.
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2009: Makide Kumiko; Kano Kuniyuki; Kitamura Hajime; Arima Naoaki; Aoki Junken
[Lysophospholipid mediators]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2009;54(1):29-39.
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2008: Ohuchi Hideyo; Hamada Aska; Matsuda Hironao; Takagi Akira; Tanaka Masayuki; Aoki Junken; Arai Hiroyuki; Noji Sumihare
Expression patterns of the lysophospholipid receptor genes during mouse early development.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(11):3280-94.
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2008: Nakasaki Tae; Tanaka Toshiyuki; Okudaira Shinichi; Hirosawa Michi; Umemoto Eiji; Otani Kazuhiro; Jin Soojung; Bai Zhongbin; Hayasaka Haruko; Fukui Yoshinori; Aozasa Katsuyuki; Fujita Naoya; Tsuruo Takashi; Ozono Keiichi; Aoki Junken; Miyasaka Masayuki
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions.
The American journal of pathology 2008;173(5):1566-76.
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2008: Masuda Akiko; Nakamura Kazuhiro; Izutsu Koji; Igarashi Koji; Ohkawa Ryunosuke; Jona Masahiro; Higashi Katsumi; Yokota Hiromitsu; Okudaira Shinichi; Kishimoto Tatsuya; Watanabe Takuro; Koike Yukako; Ikeda Hitoshi; Kozai Yasushi; Kurokawa Mineo; Aoki Junken; Yatomi Yutaka
Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma.
British journal of haematology 2008;143(1):60-70.
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2008: Aoki Junken; Inoue Asuka; Okudaira Shinichi
Two pathways for lysophosphatidic acid production.
Biochimica et biophysica acta 2008;1781(9):513-8.
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2008: Kanamori Takahiro; Inoue Takao; Sakamoto Taro; Gengyo-Ando Keiko; Tsujimoto Masafumi; Mitani Shohei; Sawa Hitoshi; Aoki Junken; Arai Hiroyuki
Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions.
The EMBO journal 2008;27(12):1647-57.
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2008: Inoue M; Xie W; Matsushita Y; Chun J; Aoki J; Ueda H
Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.
Neuroscience 2008;152(2):296-8.
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2008: Nakamura Kazuhiro; Igarashi Koji; Ide Kazufumi; Ohkawa Ryunosuke; Okubo Shigeo; Yokota Hiromitsu; Masuda Akiko; Oshima Noriko; Takeuchi Takumi; Nangaku Masaomi; Okudaira Shinichi; Arai Hiroyuki; Ikeda Hitoshi; Aoki Junken; Yatomi Yutaka
Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation.
Clinica chimica acta; international journal of clinical chemistry 2008;388(1-2):51-8.
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2008: Kono Nozomu; Inoue Takao; Yoshida Yasukazu; Sato Hiroyuki; Matsusue Tomokazu; Itabe Hiroyuki; Niki Etsuo; Aoki Junken; Arai Hiroyuki
Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo.
The Journal of biological chemistry 2008;283(3):1628-36.
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2008: Kano Kuniyuki; Arima Naoaki; Ohgami Mitsuru; Aoki Junken
LPA and its analogs-attractive tools for elucidation of LPA biology and drug development.
Current medicinal chemistry 2008;15(21):2122-31.
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2008: Inoue Makoto; Ma Lin; Aoki Junken; Chun Jerold; Ueda Hiroshi
Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.
Molecular pain 2008;4():6.
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2008: Nakamura Kazuhiro; Nangaku Masaomi; Ohkawa Ryunosuke; Okubo Shigeo; Yokota Hiromitsu; Ikeda Hitoshi; Aoki Junken; Yatomi Yutaka
Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(1):150-1.
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2007: Hama Kotaro; Aoki Junken; Inoue Asuka; Endo Tomoko; Amano Tomokazu; Motoki Rie; Kanai Motomu; Ye Xiaoqin; Chun Jerold; Matsuki Norio; Suzuki Hiroshi; Shibasaki Masakatsu; Arai Hiroyuki
Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice.
Biology of reproduction 2007;77(6):954-9.
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2007: Nakamura Kazuhiro; Takeuchi Takumi; Ohkawa Ryunosuke; Okubo Shigeo; Yokota Hiromitsu; Tozuka Minoru; Aoki Junken; Arai Hiroyuki; Ikeda Hitoshi; Ohshima Noriko; Kitamura Tadaichi; Yatomi Yutaka
Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients.
Annals of clinical biochemistry 2007;44(Pt 6):549-56.
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2007: Yamaguchi Noritaka; Koizumi Hiroyuki; Aoki Junken; Natori Yumiko; Nishikawa Kiyotaka; Natori Yasuhiro; Takanezawa Yasukazu; Arai Hiroyuki
Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(10):1153-61.
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2007: Watanabe Naoko; Ikeda Hitoshi; Nakamura Kazuhiro; Ohkawa Ryunosuke; Kume Yukio; Tomiya Tomoaki; Tejima Kazuaki; Nishikawa Takako; Arai Masahiro; Yanase Mikio; Aoki Junken; Arai Hiroyuki; Omata Masao; Fujiwara Kenji; Yatomi Yutaka
Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity.
Life sciences 2007;81(12):1009-15.
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2007: Watanabe Naoko; Ikeda Hitoshi; Nakamura Kazuhiro; Ohkawa Ryunosuke; Kume Yukio; Aoki Junken; Hama Kotaro; Okudaira Shinichi; Tanaka Masayuki; Tomiya Tomoaki; Yanase Mikio; Tejima Kazuaki; Nishikawa Takako; Arai Masahiro; Arai Hiroyuki; Omata Masao; Fujiwara Kenji; Yatomi Yutaka
Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.
Journal of clinical gastroenterology 2007;41(6):616-23.
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2007: Mori Ken; Kitayama Joji; Aoki Junken; Kishi Yasuhiro; Shida Dai; Yamashita Hiroharu; Arai Hiroyuki; Nagawa Hirokazu
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD).
Virchows Archiv : an international journal of pathology 2007;451(1):47-56.
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2007: Satoh Yumiko; Ohkawa Ryunosuke; Nakamura Kazuhiro; Higashi Katsumi; Kaneko Makoto; Yokota Hiromitsu; Aoki Junken; Arai Hiroyuki; Yuasa Yasuhito; Yatomi Yutaka
Lysophosphatidic acid protection against apoptosis in the human pre-B-cell line Nalm-6.
European journal of haematology 2007;78(6):510-7.
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2007: Tokumura Akira; Kume Tetsuya; Fukuzawa Kenji; Tahara Masahiro; Tasaka Keiichi; Aoki Junken; Arai Hiroyuki; Yasuda Katsuhiko; Kanzaki Hideharu
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity.
Life sciences 2007;80(18):1641-9.
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2007: Ohuchi Hideyo; Hayashibara Yasunori; Matsuda Hironao; Onoi Motoyoshi; Mitsumori Masayuki; Tanaka Masayuki; Aoki Junken; Arai Hiroyuki; Noji Sumihare
Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(4):1134-43.
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2007: Umemura Kimiko; Kato Ichiro; Hirashima Yutaka; Ishii Yoko; Inoue Takao; Aoki Junken; Kono Nozomu; Oya Takeshi; Hayashi Nakamasa; Hamada Hideo; Endo Shunro; Oda Masaya; Arai Hiroyuki; Kinouchi Hiroyuki; Hiraga Koichi
Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2007;38(3):1063-8.
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2007: Nakamura Kazuhiro; Ohkawa Ryunosuke; Okubo Shigeo; Tozuka Minoru; Okada Mitsumasa; Aoki Shinya; Aoki Junken; Arai Hiroyuki; Ikeda Hitoshi; Yatomi Yutaka
Measurement of lysophospholipase D/autotaxin activity in human serum samples.
Clinical biochemistry 2007;40(3-4):274-7.
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2007: Aoki Junken; Inoue Asuka; Makide Kumiko; Saiki Naoya; Arai Hiroyuki
Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family.
Biochimie 2007;89(2):197-204.
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2007: Morikawa Rei; Tsujimoto Masafumi; Arai Hiroyuki; Aoki Junken
Phospholipase A(1) assays using a radiolabeled substrate and mass spectrometry.
Methods in enzymology 2007;434():1-13.
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2006: Ohtsuki Mitsuhiro; Taketomi Yoshitaka; Arata Satoru; Masuda Seiko; Ishikawa Yukio; Ishii Toshiharu; Takanezawa Yasukazu; Aoki Junken; Arai Hiroyuki; Yamamoto Kei; Kudo Ichiro; Murakami Makoto
Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction.
The Journal of biological chemistry 2006;281(47):36420-33.
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2006: Tsuda Satomi; Okudaira Shinichi; Moriya-Ito Keiko; Shimamoto Chie; Tanaka Masayuki; Aoki Junken; Arai Hiroyuki; Murakami-Murofushi Kimiko; Kobayashi Tetsuyuki
Cyclic phosphatidic acid is produced by autotaxin in blood.
The Journal of biological chemistry 2006;281(36):26081-8.
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2006: Tanaka Masayuki; Okudaira Shinichi; Kishi Yasuhiro; Ohkawa Ryunosuke; Iseki Sachiko; Ota Masato; Noji Sumihare; Yatomi Yutaka; Aoki Junken; Arai Hiroyuki
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.
The Journal of biological chemistry 2006;281(35):25822-30.
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2006: Hama Kotaro; Aoki Junken; Bandoh Koji; Inoue Asuka; Endo Tomoko; Amano Tomokazu; Suzuki Hiroshi; Arai Hiroyuki
Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus.
Life sciences 2006;79(18):1736-40.
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2006: Okazaki Hiroaki; Igarashi Masaki; Nishi Makiko; Tajima Makiko; Sekiya Motohiro; Okazaki Sachiko; Yahagi Naoya; Ohashi Ken; Tsukamoto Kazuhisa; Amemiya-Kudo Michiyo; Matsuzaka Takashi; Shimano Hitoshi; Yamada Nobuhiro; Aoki Junken; Morikawa Rei; Takanezawa Yasukazu; Arai Hiroyuki; Nagai Ryozo; Kadowaki Takashi; Osuga Jun-Ichi; Ishibashi Shun
Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis.
Diabetes 2006;55(7):2091-7.
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2006: Kishi Yasuhiro; Okudaira Shinichi; Tanaka Masayuki; Hama Kotaro; Shida Dai; Kitayama Joji; Yamori Takao; Aoki Junken; Fujimaki Takamitsu; Arai Hiroyuki
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.
The Journal of biological chemistry 2006;281(25):17492-500.
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2006: Watanabe Nobuo; Zmijewski Jaroslaw W; Takabe Wakako; Umezu-Goto Makiko; Le Goffe Claire; Sekine Azusa; Landar Aimee; Watanabe Akira; Aoki Junken; Arai Hiroyuki; Kodama Tatsuhiko; Murphy Michael P; Kalyanaraman Raman; Darley-Usmar Victor M; Noguchi Noriko
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells.
The American journal of pathology 2006;168(5):1737-48.
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2006: Qian Lian; Xu Yong; Simper Ted; Jiang Guowei; Aoki Junken; Umezu-Goto Makiko; Arai Hiroyuki; Yu Shuangxing; Mills Gordon B; Tsukahara Ryoko; Makarova Natalia; Fujiwara Yuko; Tigyi Gabor; Prestwich Glenn D
Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists.
ChemMedChem 2006;1(3):376-83.
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2006: Yamashita Hiroharu; Kitayama Joji; Shida Dai; Ishikawa Makoto; Hama Kotaro; Aoki Junken; Arai Hiroyuki; Nagawa Hirokazu
Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer.
Journal of surgical oncology 2006;93(1):30-5.
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2006: Masuda Yutaka; Itabe Hiroyuki; Odaki Miho; Hama Kotaro; Fujimoto Yasuyuki; Mori Masahiro; Sasabe Naoko; Aoki Junken; Arai Hiroyuki; Takano Tatsuya
ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells.
Journal of lipid research 2006;47(1):87-98.
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2005: Baumforth Karl R N; Flavell Joanne R; Reynolds Gary M; Davies Gillian; Pettit Trevor R; Wei Wenbin; Morgan Susan; Stankovic Tanya; Kishi Yasuhiro; Arai Hiroyuki; Nowakova Marketa; Pratt Guy; Aoki Junken; Wakelam Michael J O; Young Lawrence S; Murray Paul G
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells.
Blood 2005;106(6):2138-46.
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2005: Sakagami Hideki; Aoki Junken; Natori Yumiko; Nishikawa Kiyotaka; Kakehi Yoshiyuki; Natori Yasuhiro; Arai Hiroyuki
Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
The Journal of biological chemistry 2005;280(24):23084-93.
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2005: Masuda Seiko; Murakami Makoto; Takanezawa Yasukazu; Aoki Junken; Arai Hiroyuki; Ishikawa Yukio; Ishii Toshiharu; Arioka Manabu; Kudo Ichiro
Neuronal expression and neuritogenic action of group X secreted phospholipase A2.
The Journal of biological chemistry 2005;280(24):23203-14.
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2005: Ye Xiaoqin; Hama Kotaro; Contos James J A; Anliker Brigitte; Inoue Asuka; Skinner Michael K; Suzuki Hiroshi; Amano Tomokazu; Kennedy Grace; Arai Hiroyuki; Aoki Junken; Chun Jerold
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing.
Nature 2005;435(7038):104-8.
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2005: Xu Yong; Aoki Junken; Shimizu Kumiko; Umezu-Goto Makiko; Hama Kotaro; Takanezawa Yasukazu; Yu Shuangxing; Mills Gordon B; Arai Hiroyuki; Qian Lian; Prestwich Glenn D
Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Journal of medicinal chemistry 2005;48(9):3319-27.
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2005: Murakami Makoto; Masuda Seiko; Ueda-Semmyo Kaori; Yoda Emiko; Kuwata Hiroshi; Takanezawa Yasukazu; Aoki Junken; Arai Hiroyuki; Sumimoto Hideki; Ishikawa Yukio; Ishii Toshiharu; Nakatani Yoshihito; Kudo Ichiro
Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2.
The Journal of biological chemistry 2005;280(14):14028-41.
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2004: Shida Dai; Kitayama Joji; Yamaguchi Hironori; Hama Kotaro; Aoki Junken; Arai Hiroyuki; Yamashita Hiroharu; Mori Ken; Sako Akihiro; Konishi Tsuyoshi; Watanabe Toshiaki; Sakai Teruyuki; Suzuki Rika; Ohta Hideo; Takuwa Yoh; Nagawa Hirokazu
Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.
Experimental cell research 2004;301(2):168-78.
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2004: Xu Yong; Tanaka Masayuki; Arai Hiroyuki; Aoki Junken; Prestwich Glenn D
Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors.
Bioorganic & medicinal chemistry letters 2004;14(21):5323-8.
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2004: Aoki Junken
Mechanisms of lysophosphatidic acid production.
Seminars in cell & developmental biology 2004;15(5):477-89.
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2004: Shida Dai; Watanabe Toshiaki; Aoki Junken; Hama Kotaro; Kitayama Joji; Sonoda Hirofumi; Kishi Yasuhiro; Yamaguchi Hironori; Sasaki Shin; Sako Akihiro; Konishi Tsuyoshi; Arai Hiroyuki; Nagawa Hirokazu
Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer.
Laboratory investigation; a journal of technical methods and pathology 2004;84(10):1352-62.
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2004: Inoue Takao; Sugimoto Asako; Suzuki Yuka; Yamamoto Masayuki; Tsujimoto Masafumi; Inoue Keizo; Aoki Junken; Arai Hiroyuki
Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13233-8.
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2004: Tanaka Masayuki; Kishi Yasuhiro; Takanezawa Yasukazu; Kakehi Yoshiyuki; Aoki Junken; Arai Hiroyuki
Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma.
FEBS letters 2004;571(1-3):197-204.
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2004: Tamaruya Yoko; Suzuki Masato; Kamura Goshu; Kanai Motomu; Hama Kotaro; Shimizu Kumiko; Aoki Junken; Arai Hiroyuki; Shibasaki Masakatsu
Identifying specific conformations by using a carbohydrate scaffold: discovery of subtype-selective LPA-receptor agonists and an antagonist.
Angewandte Chemie (International ed. in English) 2004;43(21):2834-7.
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2004: Yamaguchi Noritaka; Takanezawa Yasukazu; Koizumi Hiroyuki; Umezu-Goto Makiko; Aoki Junken; Arai Hiroyuki
Expression of NUDEL in manchette and its implication in spermatogenesis.
FEBS letters 2004;566(1-3):71-6.
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2004: Hama Kotaro; Aoki Junken; Fukaya Masahiro; Kishi Yasuhiro; Sakai Teruyuki; Suzuki Rika; Ohta Hideo; Yamori Takao; Watanabe Masahiko; Chun Jerold; Arai Hiroyuki
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
The Journal of biological chemistry 2004;279(17):17634-9.
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2004: Kitayama Joji; Shida Dai; Sako Akihiro; Ishikawa Makoto; Hama Kotaro; Aoki Junken; Arai Hiroyuki; Nagawa Hirokazu
Over-expression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma.
Breast cancer research : BCR 2004;6(6):R640-6.
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2003: Qian Lian; Xu Yong; Hasegawa Yutaka; Aoki Junken; Mills Gordon B; Prestwich Glenn D
Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
Journal of medicinal chemistry 2003;46(26):5575-8.
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2003: Hiramatsu Tatsufumi; Sonoda Hirofumi; Takanezawa Yasukazu; Morikawa Rei; Ishida Mayuko; Kasahara Kohji; Sanai Yutaka; Taguchi Ryo; Aoki Junken; Arai Hiroyuki
Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta.
The Journal of biological chemistry 2003;278(49):49438-47.
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2003: Qian Lian; Xu Yong; Arai Hiroyuki; Aoki Junken; McIntyre Thomas M; Prestwich Glenn D
Synthesis of migration-resistant hydroxyethoxy analogues of lysophosphatidic acid.
Organic letters 2003;5(24):4685-8.
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2003: Yoshida Kenji; Nishida Wataru; Hayashi Ken'ichiro; Ohkawa Yasuyuki; Ogawa Akira; Aoki Junken; Arai Hiroyuki; Sobue Kenji
Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo.
Circulation 2003;108(14):1746-52.
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2003: Caspi Michal; Coquelle Frédéric M; Koifman Cynthia; Levy Talia; Arai Hiroyuki; Aoki Junken; De Mey Jan R; Reiner Orly
LIS1 missense mutations: variable phenotypes result from unpredictable alterations in biochemical and cellular properties.
The Journal of biological chemistry 2003;278(40):38740-8.
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2003: Clair Timothy; Aoki Junken; Koh Eunjin; Bandle Russell W; Nam Suk Woo; Ptaszynska Malgorzata M; Mills Gordon B; Schiffmann Elliott; Liotta Lance A; Stracke Mary L
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Cancer research 2003;63(17):5446-53.
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2003: Aoki Junken
[Mechanism of lysophosphatidic acid production]
Seikagaku. The Journal of Japanese Biochemical Society 2003;75(7):609-13.
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2003: Kaempf-Rotzoll D E; Horiguchi M; Hashiguchi K; Aoki J; Tamai H; Linderkamp O; Arai H
Human placental trophoblast cells express alpha-tocopherol transfer protein.
Placenta 2003;24(5):439-44.
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2003: Hasegawa Yutaka; Erickson James R; Goddard Graham J; Yu Shuangxing; Liu Shuying; Cheng Kwai Wa; Eder Astrid; Bandoh Koji; Aoki Junken; Jarosz Renata; Schrier Andrew D; Lynch Kevin R; Mills Gordon B; Fang Xianjun
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
The Journal of biological chemistry 2003;278(14):11962-9.
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2003: Koizumi Hiroyuki; Yamaguchi Noritaka; Hattori Mitsuharu; Ishikawa Tomo-O; Aoki Junken; Taketo Makoto M; Inoue Keizo; Arai Hiroyuki
Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis.
The Journal of biological chemistry 2003;278(14):12489-94.
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2003: Gijsbers Rik; Aoki Junken; Arai Hiroyuki; Bollen Mathieu
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site.
FEBS letters 2003;538(1-3):60-4.
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2003: McIntyre Thomas M; Pontsler Aaron V; Silva Adriana R; St Hilaire Andy; Xu Yong; Hinshaw Jerald C; Zimmerman Guy A; Hama Kotaro; Aoki Junken; Arai Hiroyuki; Prestwich Glenn D
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):131-6.
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2002: Aoki Junken; Taira Akitsu; Takanezawa Yasukazu; Kishi Yasuhiro; Hama Kotaro; Kishimoto Tatsuya; Mizuno Koji; Saku Keijiro; Taguchi Ryo; Arai Hiroyuki
Serum lysophosphatidic acid is produced through diverse phospholipase pathways.
The Journal of biological chemistry 2002;277(50):48737-44.
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2002: Marques Mariangela; Pei Yong; Southall Michael D; Johnston John M; Arai Hiroyuki; Aoki Junken; Inoue Takao; Seltmann Holger; Zouboulis Christos C; Travers Jeffrey B
Identification of platelet-activating factor acetylhydrolase II in human skin.
The Journal of investigative dermatology 2002;119(4):913-9.
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2002: Watanabe Tomomi; Nakagawa Kentaro; Ohata Shinya; Kitagawa Daiju; Nishitai Gen; Seo Jungwon; Tanemura Shuhei; Shimizu Nao; Kishimoto Hiroyuki; Wada Teiji; Aoki Junken; Arai Hiroyuki; Iwatsubo Takeshi; Mochita Miyuki; Watanabe Toshio; Satake Masanobu; Ito Yoshiaki; Matsuyama Toshifumi; Mak Tak W; Penninger Josef M; Nishina Hiroshi; Katada Toshiaki
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Developmental biology 2002;250(2):332-47.
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2002: Ishii Junko; Adachi Hideki; Aoki Junken; Koizumi Hiroyuki; Tomita Susumu; Suzuki Toshiharu; Tsujimoto Masafumi; Inoue Keizo; Arai Hiroyuki
SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain.
The Journal of biological chemistry 2002;277(42):39696-702.
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2002: Sonoda Hirofumi; Aoki Junken; Hiramatsu Tatsufumi; Ishida Mayuko; Bandoh Koji; Nagai Yuki; Taguchi Ryo; Inoue Keizo; Arai Hiroyuki
A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid.
The Journal of biological chemistry 2002;277(37):34254-63.
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2002: Kaempf-Rotzoll D E; Igarashi K; Aoki J; Jishage K; Suzuki H; Tamai H; Linderkamp O; Arai H
Alpha-tocopherol transfer protein is specifically localized at the implantation site of pregnant mouse uterus.
Biology of reproduction 2002;67(2):599-604.
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2002: Hama Kotaro; Bandoh Koji; Kakehi Yoshiyuki; Aoki Junken; Arai Hiroyuki
Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.
FEBS letters 2002;523(1-3):187-92.
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2002: Umezu-Goto Makiko; Kishi Yasuhiro; Taira Akitsu; Hama Kotaro; Dohmae Naoshi; Takio Koji; Yamori Takao; Mills Gordon B; Inoue Keizo; Aoki Junken; Arai Hiroyuki
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
The Journal of cell biology 2002;158(2):227-33.
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2002: Kawamoto Keiko; Aoki Junken; Tanaka Akane; Itakura Atsuko; Hosono Hiroyuki; Arai Hiroyuki; Kiso Yasuo; Matsuda Hiroshi
Nerve growth factor activates mast cells through the collaborative interaction with lysophosphatidylserine expressed on the membrane surface of activated platelets.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6412-9.
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2002: Aoki Junken; Nagai Yuki; Hosono Hiroyuki; Inoue Keizo; Arai Hiroyuki
Structure and function of phosphatidylserine-specific phospholipase A1.
Biochimica et biophysica acta 2002;1582(1-3):26-32.
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2002: Nishikawa Kiyotaka; Matsuoka Koji; Kita Eiji; Okabe Noriko; Mizuguchi Masashi; Hino Kumiko; Miyazawa Shinobu; Yamasaki Chisato; Aoki Junken; Takashima Sachio; Yamakawa Yoshio; Nishijima Masahiro; Terunuma Daiyo; Kuzuhara Hiroyoshi; Natori Yasuhiro
A therapeutic agent with oriented carbohydrates for treatment of infections by Shiga toxin-producing Escherichia coli O157:H7.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7669-74.
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2002: Arai Hiroyuki; Koizumi Hiroyuki; Aoki Junken; Inoue Keizo
Platelet-activating factor acetylhydrolase (PAF-AH).
Journal of biochemistry 2002;131(5):635-40.
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2002: Nakajima Ken-ichi; Sonoda Hirofumi; Mizoguchi Toshihide; Aoki Junken; Arai Hiroyuki; Nagahama Masami; Tagaya Mitsuo; Tani Katsuko
A novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125.
The Journal of biological chemistry 2002;277(13):11329-35.
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2002: Mills Gordon B; Eder Astrid; Fang Xianjun; Hasegawa Yutaka; Mao Muling; Lu Yiling; Tanyi Janos; Tabassam Fazal Haq; Wiener Jon; Lapushin Ruth; Yu Shiangxing; Parrott Jeff A; Compton Tim; Tribley Walter; Fishman David; Stack M Sharon; Gaudette Douglas; Jaffe Robert; Furui Tatsuro; Aoki Junken; Erickson James R
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Cancer treatment and research 2002;107():259-83.
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2001: Hayashi K; Takahashi M; Nishida W; Yoshida K; Ohkawa Y; Kitabatake A; Aoki J; Arai H; Sobue K
Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids.
Circulation research 2001;89(3):251-8.
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2001: Hosono H; Aoki J; Nagai Y; Bandoh K; Ishida M; Taguchi R; Arai H; Inoue K
Phosphatidylserine-specific phospholipase A1 stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lysophosphatidylserine.
The Journal of biological chemistry 2001;276(32):29664-70.
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2001: Erickson J R; Hasegawa Y; Fang X; Eder A; Mao M; Furui T; Aoki J; Morris A; Mills G B
Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management.
Prostaglandins & other lipid mediators 2001;64(1-4):63-81.
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2000: McMullen T W; Li J; Sheffield P J; Aoki J; Martin T W; Arai H; Inoue K; Derewenda Z S
The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib).
Protein engineering 2000;13(12):865-71.
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2000: Bae K; Longobardi L; Karasawa K; Malone B; Inoue T; Aoki J; Arai H; Inoue K; Lee T
Platelet-activating factor (PAF)-dependent transacetylase and its relationship with PAF acetylhydrolases.
The Journal of biological chemistry 2000;275(35):26704-9.
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2000: Kitagawa M; Umezu M; Aoki J; Koizumi H; Arai H; Inoue K
Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE.
FEBS letters 2000;479(1-2):57-62.
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2000: Bandoh K; Aoki J; Taira A; Tsujimoto M; Arai H; Inoue K
Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors.
FEBS letters 2000;478(1-2):159-65.
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2000: Eder A M; Sasagawa T; Mao M; Aoki J; Mills G B
Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2482-91.
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2000: Ikemoto M; Arai H; Feng D; Tanaka K; Aoki J; Dohmae N; Takio K; Adachi H; Tsujimoto M; Inoue K
Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6538-43.
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2000: Aoki J; Bandoh K; Inoue K
A novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid with unsaturated fatty-acid moiety.
Annals of the New York Academy of Sciences 2000;905():263-6.
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2000: Sheffield P J; Garrard S; Caspi M; Aoki J; Arai H; Derewenda U; Inoue K; Suter B; Reiner O; Derewenda Z S
Homologs of the alpha- and beta-subunits of mammalian brain platelet-activating factor acetylhydrolase Ib in the Drosophila melanogaster genome.
Proteins 2000;39(1):1-8.
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1999: Sapir T; Eisenstein M; Burgess H A; Horesh D; Cahana A; Aoki J; Hattori M; Arai H; Inoue K; Reiner O
Analysis of lissencephaly-causing LIS1 mutations.
European journal of biochemistry / FEBS 1999;266(3):1011-20.
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1999: Manya H; Aoki J; Kato H; Ishii J; Hino S; Arai H; Inoue K
Biochemical characterization of various catalytic complexes of the brain platelet-activating factor acetylhydrolase.
The Journal of biological chemistry 1999;274(45):31827-32.
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1999: Bandoh K; Aoki J; Hosono H; Kobayashi S; Kobayashi T; Murakami-Murofushi K; Tsujimoto M; Arai H; Inoue K
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid.
The Journal of biological chemistry 1999;274(39):27776-85.
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1999: Ho Y S; Sheffield P J; Masuyama J; Arai H; Li J; Aoki J; Inoue K; Derewenda U; Derewenda Z S
Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase.
Protein engineering 1999;12(8):693-700.
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1999: Aoki J
[Structure and function of phosphatidylserine-specific phospholipase A1: PS-PLA1]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(8 Suppl):1038-42.
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1999: Nagai Y; Aoki J; Sato T; Amano K; Matsuda Y; Arai H; Inoue K
An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans.
The Journal of biological chemistry 1999;274(16):11053-9.
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1998: Hosomi A; Goto K; Kondo H; Iwatsubo T; Yokota T; Ogawa M; Arita M; Aoki J; Arai H; Inoue K
Localization of alpha-tocopherol transfer protein in rat brain.
Neuroscience letters 1998;256(3):159-62.
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1998: Manya H; Aoki J; Watanabe M; Adachi T; Asou H; Inoue Y; Arai H; Inoue K
Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain.
The Journal of biological chemistry 1998;273(29):18567-72.
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1998: Wei Y; Swenson L; Castro C; Derewenda U; Minor W; Arai H; Aoki J; Inoue K; Servin-Gonzalez L; Derewenda Z S
Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution.
Structure (London, England : 1993) 1998;6(4):511-9.
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1998: Watanabe M; Aoki J; Manya H; Arai H; Inoue K
Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase.
Biochimica et biophysica acta 1998;1401(1):73-9.
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1997: Matsuzawa A; Hattori K; Aoki J; Arai H; Inoue K
Protection against oxidative stress-induced cell death by intracellular platelet-activating factor-acetylhydrolase II.
The Journal of biological chemistry 1997;272(51):32315-20.
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1997: Adachi T; Aoki J; Manya H; Asou H; Arai H; Inoue K
PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells.
Neuroscience letters 1997;235(3):133-6.
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1997: Sato T; Aoki J; Nagai Y; Dohmae N; Takio K; Doi T; Arai H; Inoue K
Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family.
The Journal of biological chemistry 1997;272(4):2192-8.
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1997: Ho Y S; Swenson L; Derewenda U; Serre L; Wei Y; Dauter Z; Hattori M; Adachi T; Aoki J; Arai H; Inoue K; Derewenda Z S
Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer.
Nature 1997;385(6611):89-93.
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1996: Hattori K; Adachi H; Matsuzawa A; Yamamoto K; Tsujimoto M; Aoki J; Hattori M; Arai H; Inoue K
cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase.
The Journal of biological chemistry 1996;271(51):33032-8.
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1996: Hattori M; Aoki J; Arai H; Inoue K
PAF and PAF acetylhydrolase in the nervous system.
Journal of lipid mediators and cell signalling 1996;14(1-3):99-102.
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1995: Hattori M; Adachi H; Aoki J; Tsujimoto M; Arai H; Inoue K
Cloning and expression of a cDNA encoding the beta-subunit (30-kDa subunit) of bovine brain platelet-activating factor acetylhydrolase.
The Journal of biological chemistry 1995;270(52):31345-52.
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1994: Reza F; Igarashi K; Tokita S; Asai K; Aoki J; Asaoka Y; Umeda M; Inoue K
Anti-idiotypic monoclonal antibody recognizes a consensus recognition site for phosphatidylserine in phosphatidylserine-specific monoclonal antibody and protein kinase C.
FEBS letters 1994;339(3):229-33.
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1992: Aoki J; Umeda M
[Neural cell adhesion molecule: structure and function]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1992;37(11 Suppl):1759-67.
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1991: Aoki J; Umeda M; Takio K; Titani K; Utsumi H; Sasaki M; Inoue K
Neural cell adhesion molecule mediates contact-dependent inhibition of growth of near-diploid mouse fibroblast cell line m5S/1M.
The Journal of cell biology 1991;115(6):1751-61.
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