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Toru Furukawa

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Disorders

Genes & Molecular Sequences

Genes, Tumor Suppressor

Anatomy

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Takenori Ogawa; Kazumi Ogawa; Kiyoto Shiga; Toru Furukawa; Hiroki Nagase; Sho Hashimoto; Toshimitsu Kobayashi; Akira Horii
Upregulation of IGF2 is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma.
Hidekazu Oishi; Makoto Sunamura; Shinichi Egawa; Fuyuhiko Motoi; Michiaki Unno; Toru Furukawa; Nagy A Habib; Hideo Yagita
Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer.
Takenori Ogawa; Toru Furukawa; Kiyoto Shiga; Sho Hashimoto; Kazumi Ogawa; Toshimitsu Kobayashi; Akira Horii
A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines.

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2010: Takenori Ogawa; Kazumi Ogawa; Kiyoto Shiga; Toru Furukawa; Hiroki Nagase; Sho Hashimoto; Toshimitsu Kobayashi; Akira Horii
Upregulation of IGF2 is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2010;267(10):1599-606.
2010: Hidekazu Oishi; Makoto Sunamura; Shinichi Egawa; Fuyuhiko Motoi; Michiaki Unno; Toru Furukawa; Nagy A Habib; Hideo Yagita
Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer.
Pancreas 2010;39(6):897-903.
2010: Takenori Ogawa; Toru Furukawa; Kiyoto Shiga; Sho Hashimoto; Kazumi Ogawa; Toshimitsu Kobayashi; Akira Horii
A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2010;267(1):123-9.
2009: Takahiro Tabata; Nobukazu Tsukamoto; Abbas Ali Imani Fooladi; Sumitaka Yamanaka; Toru Furukawa; Masaharu Ishida; Daisuke Sato; Zhaodi Gu; Hiroki Nagase; Shinichi Egawa; Makoto Sunamura; Akira Horii
RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells.
Biochemical and biophysical research communications 2009;390(3):475-80.
2009: Yoshinori Sasaki; Tomoyuki Ohtani; Yumiko Ito; Masato Mizuashi; Satoshi Nakagawa; Toru Furukawa; Akira Horii; Setsuya Aiba
Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production.
International archives of allergy and immunology 2009;148(3):239-50.
2008: Masaharu Ishida; Makoto Sunamura; Toru Furukawa; Liviu P Lefter; Rina Morita; Masanori Akada; Shinichi Egawa; Michiaki Unno; Akira Horii
The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer.
Digestive diseases and sciences 2008;53(9):2576-82.
2008: Masaharu Ishida; Shinichi Egawa; Kei Kawaguchi; Takeshi Aoki; Naoaki Sakata; Yukio Mikami; Fuyuhiko Motoi; Tadayoshi Abe; Shoji Fukuyama; Yu Katayose; Makoto Sunamura; Michiaki Unno; Takuya Moriya; Akira Horii; Toru Furukawa
Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2008;8(6):577-82.
2007: Masaharu Ishida; Shinichi Egawa; Takeshi Aoki; Naoaki Sakata; Yukio Mikami; Fuyuhiko Motoi; Tadayoshi Abe; Shoji Fukuyama; Makoto Sunamura; Michiaki Unno; Takuya Moriya; Akira Horii; Toru Furukawa
Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas.
Pancreas 2007;35(4):348-52.
2007: Masaharu Ishida; Makoto Sunamura; Toru Furukawa; Masanori Akada; Hiroko Fujimura; Emiko Shibuya; Shinichi Egawa; Michiaki Unno; Akira Horii
Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis.
World journal of gastroenterology : WJG 2007;13(34):4593-7.
2007: Masaharu Ishida; Shinichi Egawa; Naoaki Sakata; Yukio Mikami; Fuyuhiko Motoi; Tadayoshi Abe; Shoji Fukuyama; Makoto Sunamura; Toru Furukawa; Michiaki Unno
Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma.
Journal of hepato-biliary-pancreatic surgery 2007;14(5):522-5.
2006: Toru Furukawa; Akira Horii
[Mechanistic insights for pancreatic carcinogenesis].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 1():27-31.
2006: Ralph Hruban; N Volkan Adsay; Jorge Albores-Saavedra; Miriam R Anver; Andrew V Biankin; Gregory P Boivin; Emma E Furth; Toru Furukawa; Alison P Klein; David S Klimstra; Gunter Kloppel; Gregory Y Lauwers; Daniel S Longnecker; Jutta Luttges; Anirban Maitra; G Johan A Offerhaus; Lucía Pérez-Gallego; Mark Redston; David A Tuveson
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.
Cancer research 2006;66(1):95-106.
2006: Toru Furukawa; Makoto Sunamura; Akira Horii
Molecular mechanisms of pancreatic carcinogenesis.
Cancer science 2006;97(1):1-7.
2005: Toru Furukawa; Günter Klöppel; N Volkan Adsay; Jorge Albores-Saavedra; Noriyoshi Fukushima; Akira Horii; Ralph Hruban; Yo Kato; David S Klimstra; Daniel S Longnecker; Jutta Lüttges; G Johan A Offerhaus; Michio Shimizu; Makoto Sunamura; Arief Suriawinata; Kyoichi Takaori; Suguru Yonezawa
Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study.
Virchows Archiv : an international journal of pathology 2005;447(5):794-9.
2005: Toru Furukawa; Rumi Fujisaki; Yoshitaro Yoshida; Naomi Kanai; Makoto Sunamura; Tadayoshi Abe; Kazunori Takeda; Seiki Matsuno; Akira Horii
Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(8):1034-42.
2005: Chunlan Sun; Takashi Yamato; Emiko Kondo; Toru Furukawa; Hidetoshi Ikeda; Akira Horii
Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1.
Journal of neuro-oncology 2005;73(2):131-4.
2005: Tatsuo Hata; Toru Furukawa; Makoto Sunamura; Shinichi Egawa; Fuyuhiko Motoi; Noriyuki Ohmura; Tomotoshi Marumoto; Hideyuki Saya; Akira Horii
RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.
Cancer research 2005;65(7):2899-905.
2005: Shanhai Xu; Toru Furukawa; Naomi Kanai; Makoto Sunamura; Akira Horii
Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.
Journal of human genetics 2005;50(4):159-67.
2004: Toshimasa Yatsuoka; Toru Furukawa; Makoto Sunamura; Seiki Matsuno; Akira Horii
TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells.
Oncology reports 2004;12(6):1263-8.
2004: Sumitaka Yamanaka; Makoto Sunamura; Toru Furukawa; Libo Sun; Liviu P Lefter; Tadayoshi Abe; Toshimasa Yatsuoka; Hiroko Fujimura; Emiko Shibuya; Noriko Kotobuki; Mitsuo Oshimura; Akira Sakurada; Masami Sato; Takashi Kondo; Seiki Matsuno; Akira Horii
Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis.
Laboratory investigation; a journal of technical methods and pathology 2004;84(10):1339-51.
2004: Ralph Hruban; Kyoichi Takaori; David S Klimstra; N Volkan Adsay; Jorge Albores-Saavedra; Andrew V Biankin; Sandra A Biankin; Carolyn Corlies Compton; Noriyoshi Fukushima; Toru Furukawa; Michael Goggins; Yo Kato; Günter Klöppel; Daniel S Longnecker; Jutta Lüttges; Anirban Maitra; G Johan A Offerhaus; Michio Shimizu; Suguru Yonezawa
An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms.
The American journal of surgical pathology 2004;28(8):977-87.
2004: Makoto Sunamura; Liviu P Lefter; Dan G Duda; Rina Morita; Hiroko Inoue; Tadaaki Yokoyama; Toshimasa Yatsuoka; Tadayoshi Abe; Shinichi Egawa; Toru Furukawa; Shinichi Fukushige; Mitsuo Oshimura; Akira Horii; Seiki Matsuno
The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.
Pancreas 2004;28(3):311-6.
2004: Toru Furukawa; Akira Horii
Molecular pathology of pancreatic cancer: in quest of tumor suppressor genes.
Pancreas 2004;28(3):253-6.
2004: Tatsuo Hata; Takenori Ogawa; Tada-aki Yokoyama; Shinichi Fukushige; Akira Horii; Toru Furukawa
DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.
International journal of oncology 2004;24(3):513-20.
2003: Liviu P Lefter; Makoto Sunamura; Toru Furukawa; Kazunori Takeda; Noriko Kotobuki; Mitsuo Oshimura; Seiki Matsuno; Akira Horii
Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):5044-52.
2003: Dan G Duda; Makoto Sunamura; Liviu P Lefter; Toru Furukawa; Tadaaki Yokoyama; Toshimasa Yatsuoka; Tadayoshi Abe; Hiroko Inoue; Fuyuhiko Motoi; Shinichi Egawa; Seiki Matsuno; Akira Horii
Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.
Oncogene 2003;22(44):6857-64.
2003: Takenori Ogawa; Kiyoto Shiga; Sho Hashimoto; Toshimitsu Kobayashi; Akira Horii; Toru Furukawa
APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line.
Biochemical and biophysical research communications 2003;306(2):537-43.
2003: Toru Furukawa; Makoto Sunamura; Fuyuhiko Motoi; Seiki Matsuno; Akira Horii
Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer.
The American journal of pathology 2003;162(6):1807-15.
2002: Liviu P Lefter; Toru Furukawa; Makoto Sunamura; Dan G Duda; Kazunori Takeda; Noriko Kotobuki; Mitsuo Oshimura; Seiki Matsuno; Akira Horii
Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.
Genes, chromosomes & cancer 2002;34(2):234-42.
2001: Hiroko Inoue; Toru Furukawa; Makoto Sunamura; Kazunori Takeda; Seiki Matsuno; Akira Horii
Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis.
Genes, chromosomes & cancer 2001;31(3):295-9.
2001: K Sakurada; Toru Furukawa; Y Kato; T Kayama; S Huang; Akira Horii
RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.
Genes, chromosomes & cancer 2001;30(2):207-11.
2001: N Makino; T Yamato; Hiroko Inoue; Toru Furukawa; Tadayoshi Abe; Tada-aki Yokoyama; Toshimasa Yatsuoka; Shinichi Fukushige; S Orikasa; T Takahashi; Akira Horii
Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer.
DNA sequence : the journal of DNA sequencing and mapping 2001;11(6):547-53.
2001: EM Youssef; K Kaneko; Toshimasa Yatsuoka; Y Hayashi; M Hoshi; Akira Horii; Toru Furukawa
Human BAC contig covering the deleted region in pancreatic cancer at 12q21.
DNA sequence : the journal of DNA sequencing and mapping 2001;11(6):541-6.
2001: K Kaneko; Y Nagasaki; Toru Furukawa; Hiroya Mizutamari; A Sato; Atsushi Masamune; Tooru Shimosegawa; Akira Horii
Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis.
Journal of human genetics 2001;46(5):293-7.
2001: Chunlan Sun; T Yamato; Toru Furukawa; Y Ohnishi; H Kijima; Akira Horii
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Oncology reports 2001;8(1):89-92.
2000: E Kondo; Toru Furukawa; K Yoshinaga; H Kijima; S Semba; Toshimasa Yatsuoka; Tada-aki Yokoyama; Shinichi Fukushige; Akira Horii
Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability.
International journal of oncology 2000;17(3):535-41.
2000: Toshimasa Yatsuoka; Makoto Sunamura; Toru Furukawa; Shinichi Fukushige; Tada-aki Yokoyama; Hiroko Inoue; K Shibuya; Kazunori Takeda; Seiki Matsuno; Akira Horii
Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma.
The American journal of gastroenterology 2000;95(8):2080-5.
2000: A Saito; Toru Furukawa; Shinichi Fukushige; S Koyama; M Hoshi; Y Hayashi; Akira Horii
p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1.
Journal of human genetics 2000;45(3):177-81.
1999: A Sakurada; H Hamada; Shinichi Fukushige; Tada-aki Yokoyama; K Yoshinaga; Toru Furukawa; S Sato; A Yajima; M Sato; S Fujimura; Akira Horii
Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.
International journal of oncology 1999;15(6):1069-74.
1999: Tadayoshi Abe; N Makino; Toru Furukawa; H Ouyang; M Kimura; Toshimasa Yatsuoka; Tada-aki Yokoyama; Hiroko Inoue; Shinichi Fukushige; M Hoshi; Y Hayashi; Makoto Sunamura; M Kobari; Seiki Matsuno; Akira Horii
Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer.
Genes, chromosomes & cancer 1999;25(1):60-4.
1999: Toshimasa Yatsuoka; Toru Furukawa; Tadayoshi Abe; Tada-aki Yokoyama; Makoto Sunamura; M Kobari; Seiki Matsuno; Akira Horii
Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 in human pancreatic ductal adenocarcinoma.
International journal of pancreatology : official journal of the International Association of Pancreatology 1999;25(2):97-102.
1999: S Han; S Semba; Tadayoshi Abe; N Makino; Toru Furukawa; Shinichi Fukushige; H Takahashi; A Sakurada; M Sato; K Shiiba; S Matsuno; Y Nimura; A Nakagawara; Akira Horii
Infrequent somatic mutations of the p73 gene in various human cancers.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 1999;25(2):194-8.
1999: Toru Furukawa; EM Youssef; Toshimasa Yatsuoka; Tada-aki Yokoyama; N Makino; Hiroko Inoue; Shinichi Fukushige; M Hoshi; Y Hayashi; Makoto Sunamura; Akira Horii
Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue (hGnT-IV-H) gene.
Journal of human genetics 1999;44(6):397-401.
1998: K Yoshinaga; Hironobu Sasano; Toru Furukawa; H Yamakawa; M Yuki; S Sato; A Yajima; Akira Horii
The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia.
Japanese journal of cancer research : Gann 1998;89(10):985-90.
1998: Shinichi Fukushige; Toru Furukawa; K Satoh; Makoto Sunamura; M Kobari; M Koizumi; Akira Horii
Loss of chromosome 18q is an early event in pancreatic ductal tumorigenesis.
Cancer research 1998;58(19):4222-6.
1998: H Yamakawa; S Nagase; M Yuki; HO Shiwaku; Toru Furukawa; K Yoshinaga; E Soeda; M Hoshi; Y Hayashi; S Sato; A Yajima; Akira Horii
Identification of a 100-kb region of common allelic loss on chromosome bands 10q25-q26 in human endometrial cancer.
Genes, chromosomes & cancer 1998;23(1):74-7.
1998: M Kimura; Toru Furukawa; Tadayoshi Abe; Toshimasa Yatsuoka; EM Youssef; Tada-aki Yokoyama; H Ouyang; Y Ohnishi; Makoto Sunamura; M Kobari; Seiki Matsuno; Akira Horii
Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer.
Cancer research 1998;58(11):2456-60.
1998: H Ouyang; Toru Furukawa; T Abe; Y Kato; Akira Horii
The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):1071-4.
1997: Shinichi Fukushige; F M Waldman; M Kimura; Tadayoshi Abe; Toru Furukawa; Makoto Sunamura; M Kobari; Akira Horii
Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma.
Genes, chromosomes & cancer 1997;19(3):161-9.