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Takashi Furuta

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Hiromi Shibasaki; Atsushi Suzuki; Akitomo Yokokawa; Mari Goto; Kaori Hosoda; Kazuo Ishii; Takashi Furuta
Intraindividual and interindividual variabilities in endogenous cortisol 6β-hydroxylation clearance as an index for in vivo CYP3A phenotyping in humans.
Akitomo Yokokawa; Yasuji Kasuya; Soko Kawashima; Hiromi Shibasaki; Toru Takasaka; Akira Yamada; Takashi Furuta
The effect of water loading on the urinary ratio of cortisone to cortisol in healthy subjects and a new approach to the evaluation of the ratio as an index for in vivo human 11β-hydroxysteroid dehydrogenase 2 activity.
Hiromi Shibasaki; Akitomo Yokokawa; Risako Inoue; Sawako Okamoto; Misato Okita; Takashi Furuta
Separation and quantitative determination of 6α-hydroxycortisol and 6β-hydroxycortisol in human urine by high-performance liquid chromatography with ultraviolet absorption detection.

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All Publications

2013: Hiromi Shibasaki; Atsushi Suzuki; Akitomo Yokokawa; Mari Goto; Kaori Hosoda; Kazuo Ishii; Takashi Furuta
Intraindividual and interindividual variabilities in endogenous cortisol 6β-hydroxylation clearance as an index for in vivo CYP3A phenotyping in humans.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(2):475-9.
2012: Akitomo Yokokawa; Yasuji Kasuya; Soko Kawashima; Hiromi Shibasaki; Toru Takasaka; Akira Yamada; Takashi Furuta
The effect of water loading on the urinary ratio of cortisone to cortisol in healthy subjects and a new approach to the evaluation of the ratio as an index for in vivo human 11β-hydroxysteroid dehydrogenase 2 activity.
Steroids 2012;77(12):1291-7.
2012: Hiromi Shibasaki; Akitomo Yokokawa; Risako Inoue; Sawako Okamoto; Misato Okita; Takashi Furuta
Separation and quantitative determination of 6α-hydroxycortisol and 6β-hydroxycortisol in human urine by high-performance liquid chromatography with ultraviolet absorption detection.
Analytical and bioanalytical chemistry 2012;402(9):2945-52.
2009: Akitomo Yokokawa; Kazuhiro Yamamoto; Yuhei Omori; Hiromi Shibasaki; Yoshihiko Shinohara; Yasuji Kasuya; Takashi Furuta
Simultaneous determination of androstenedione, 11beta-hydroxyandrostenedione, and testosterone in human plasma by stable isotope dilution mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(7):621-6.
2008: Hiromi Shibasaki; Hideaki Nakayama; Takashi Furuta; Yasuji Kasuya; Mari Tsuchiya; Akinori Soejima; Akira Yamada; Toshihiko Nagasawa
Simultaneous determination of prednisolone, prednisone, cortisol, and cortisone in plasma by GC-MS: estimating unbound prednisolone concentration in patients with nephrotic syndrome during oral prednisolone therapy.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;870(2):164-9.
2005: Yasuji Kasuya; Akitomo Yokokawa; Kouichi Hamura; Hiromi Shibasaki; Takashi Furuta
Validation of the plasma half-life of 11alpha-deuterium cortisol as a sensitive index for the analysis of human 11beta-HSD2 activity in vivo.
Steroids 2005;70(12):811-6.
2005: Yasuji Kasuya; Akitomo Yokokawa; Satoshi Takashima; Hiromi Shibasaki; Takashi Furuta
Use of 11alpha-deuterium labeled cortisol as a tracer for assessing reduced 11beta-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject.
Steroids 2005;70(2):117-25.
2004: Takashi Furuta; Chieko Mori; Atsushi Suzuki; Hiromi Shibasaki; Akitomo Yokokawa; Yasuji Kasuya
Simultaneous determination of 6beta-hydroxycortisol and cortisol in human urine by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity determined by the cortisol 6beta-hydroxylation clearance.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;801(2):165-71.
2003: Takashi Furuta; Atsushi Suzuki; Chieko Mori; Hiromi Shibasaki; Akitomo Yokokawa; Yasuji Kasuya
Evidence for the validity of cortisol 6 beta-hydroxylation clearance as a new index for in vivo cytochrome P450 3A phenotyping in humans.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1283-7.
2003: Takashi Furuta; Atsushi Suzuki; Mitsuhiro Matsuzawa; Hiromi Shibasaki; Yasuji Kasuya
Syntheses of stable isotope-labeled 6 beta-hydroxycortisol, 6 beta-hydroxycortisone, and 6 beta-hydroxytestosterone.
Steroids 2003;68(7-8):693-703.
2003: Yasuji Kasuya; Akitomo Yokokawa; Shinji Takayama; Hiromi Shibasaki; Takashi Furuta
Evaluation of 11beta-HSD activities in vivo following oral administration of cortisol-13C4,2H1 to a human subject.
Steroids 2003;68(2):167-76.
2002: Yasuji Kasuya; Akitomo Yokokawa; Hiromi Shibasaki; Takashi Furuta
Measurement of cortisol secretion rate by stable isotope methodology following oral administration of 13C-labeled cortisol to a human subject.
Steroids 2002;67(9):783-8.
2001: Hiromi Shibasaki; C Tanabe; Takashi Furuta; Yasuji Kasuya
Hydrolysis of conjugated steroids by the combined use of beta-glucuronidase preparations from helix pomatia and ampullaria: determination of urinary cortisol and its metabolites.
Steroids 2001;66(11):795-801.
2000: Takashi Furuta; N Eguchi; Akitomo Yokokawa; Hiromi Shibasaki; Yasuji Kasuya
Synthesis of multi-labeled cortisols and cortisones with (2)H and (13)C for study of cortisol metabolism in humans.
Steroids 2000;65(4):180-9.
2000: Takashi Furuta; M Matsuzawa; Hiromi Shibasaki; Yasuji Kasuya
Simultaneous determination of 6beta- and 6alpha-hydroxycortisols and 6beta-hydroxycortisone in human urine by stable isotope dilution mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2000;738(2):367-76.
2000: Yasuji Kasuya; Hiromi Shibasaki; Takashi Furuta
The use of deuterium-labeled cortisol for in vivo evaluation of renal 11beta-HSD activity in man: urinary excretion of cortisol, cortisone and their A-ring reduced metabolites.
Steroids 2000;65(2):89-97.
2000: Takashi Furuta; N Eguchi; Hiromi Shibasaki; Yasuji Kasuya
Simultaneous determination of endogenous and 13C-labelled cortisols and cortisones in human plasma by stable isotope dilution mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2000;738(1):119-27.
1999: Takashi Furuta; T Namekawa; Hiromi Shibasaki; Yasuji Kasuya
Synthesis of deuterium-labeled tetrahydrocortisol and tetrahydrocortisone for study of cortisol metabolism in humans.
Steroids 1999;64(12):805-11.
1998: Takashi Furuta; T Namekawa; Hiromi Shibasaki; Yasuji Kasuya
Simultaneous determination of tetrahydrocortisol and tetrahydrocortisone in human plasma and urine by stable isotope dilution mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 1998;706(2):181-90.
1998: Yasuji Kasuya; H Ishimaru; Hiromi Shibasaki; Takashi Furuta
Stable isotope methodology for kinetic studies of interconversion of cortisol and cortisone in a human subject.
Steroids 1998;63(3):122-9.
1997: Hiromi Shibasaki; Takashi Furuta; Yasuji Kasuya
Quantification of corticosteroids in human plasma by liquid chromatography-thermospray mass spectrometry using stable isotope dilution.
Journal of chromatography. B, Biomedical sciences and applications 1997;692(1):7-14.
1996: Takashi Furuta; K Okamiya; Hiromi Shibasaki; Yasuji Kasuya
Pharmacokinetics of stable isotopically labeled L-histidine in humans and the assessment of in vivo histidine ammonia lyase activities.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(1):49-54.
1992: Hiromi Shibasaki; Takashi Furuta; Yasuji Kasuya
Stable isotope dilution mass spectrometry for the simultaneous determination of cortisol, cortisone, prednisolone and prednisone in plasma.
Journal of chromatography 1992;579(2):193-202.
1992: Hiromi Shibasaki; Takashi Furuta; Yasuji Kasuya
Stereochemical aspects in the enantioselective synthesis of cortisone by the indan synthon method.
Steroids 1992;57(7):325-7.
1992: Takashi Furuta; H Takahashi; Hiromi Shibasaki; Yasuji Kasuya
Reversible stepwise mechanism involving a carbanion intermediate in the elimination of ammonia from L-histidine catalyzed by histidine ammonia-lyase.
The Journal of biological chemistry 1992;267(18):12600-5.
1992: Takashi Furuta; M Katayama; Hiromi Shibasaki; Yasuji Kasuya
Simultaneous determination of stable isotopically labelled L-histidine and urocanic acid in human plasma by stable isotope dilution mass spectrometry.
Journal of chromatography 1992;576(2):213-9.
1992: Hiromi Shibasaki; I Arai; Takashi Furuta; Yasuji Kasuya
Simultaneous determination of cortisol and cortisone in human plasma by stable-isotope dilution mass spectrometry.
Journal of chromatography 1992;576(1):47-52.
1992: Hiromi Shibasaki; Takashi Furuta; Yasuji Kasuya
Preparation of multiply deuterium-labeled cortisol.
Steroids 1992;57(1):13-7.