Alfredo Fusco

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Federico Antonella; Pallante Pierlorenzo; Bianco Mimma; Ferraro Angelo; Esposito Francesco; Monti Maria; Cozzolino Marianna; Keller Simona; Fedele Monica; Leone Vincenza; Troncone Giancarlo; Chiariotti Lorenzo; Pucci Piero; Fusco Alfredo
Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein.
Fedele Monica; Palmieri Dario; Chiappetta Gennaro; Pasquinelli Rosa; De Martino Ivana; Arra Claudio; Palma Giuseppe; Valentino Teresa; Pierantoni Giovanna M; Viglietto Giuseppe; Rothstein Jay L; Santoro Massimo; Fusco Alfredo
Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice.
Troncone Giancarlo; Guerriero Eliana; Pallante Pierlorenzo; Berlingieri Maria Teresa; Ferraro Angelo; Del Vecchio Luigi; Gorrese Marisa; Mariotti Elisabetta; Iaccarino Antonino; Palmieri Emiliano A; Zeppa Pio; Palombini Lucio; Fusco Alfredo
UbcH10 expression in human lymphomas.

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2009: Federico Antonella; Pallante Pierlorenzo; Bianco Mimma; Ferraro Angelo; Esposito Francesco; Monti Maria; Cozzolino Marianna; Keller Simona; Fedele Monica; Leone Vincenza; Troncone Giancarlo; Chiariotti Lorenzo; Pucci Piero; Fusco Alfredo
Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein.
Cancer research 2009;69(17):7079-87.
2009: Fedele Monica; Palmieri Dario; Chiappetta Gennaro; Pasquinelli Rosa; De Martino Ivana; Arra Claudio; Palma Giuseppe; Valentino Teresa; Pierantoni Giovanna M; Viglietto Giuseppe; Rothstein Jay L; Santoro Massimo; Fusco Alfredo
Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice.
Endocrine-related cancer 2009;16(2):483-90.
2009: Troncone Giancarlo; Guerriero Eliana; Pallante Pierlorenzo; Berlingieri Maria Teresa; Ferraro Angelo; Del Vecchio Luigi; Gorrese Marisa; Mariotti Elisabetta; Iaccarino Antonino; Palmieri Emiliano A; Zeppa Pio; Palombini Lucio; Fusco Alfredo
UbcH10 expression in human lymphomas.
Histopathology 2009;54(6):731-40.
2009: Castellone Maria Domenica; De Falco Valentina; Rao Deva Magendra; Bellelli Roberto; Muthu Magesh; Basolo Fulvio; Fusco Alfredo; Gutkind J Silvio; Santoro Massimo
The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.
Cancer research 2009;69(5):1867-76.
2009: De Martino Ivana; Visone Rosa; Wierinckx Anne; Palmieri Dario; Ferraro Angelo; Cappabianca Paolo; Chiappetta Gennaro; Forzati Floriana; Lombardi Gaetano; Colao Annamaria; Trouillas Jacqueline; Fedele Monica; Fusco Alfredo
HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas.
Cancer research 2009;69(5):1844-50.
2009: De Martino I; Visone R; Fedele M; Petrocca F; Palmieri D; Martinez Hoyos J; Forzati F; Croce C M; Fusco A
Regulation of microRNA expression by HMGA1 proteins.
Oncogene 2009;28(11):1432-42.
2009: Iuliano Rodolfo; Raso Cinzia; Quintiero Alfina; Pera Ilaria Le; Pichiorri Flavia; Palumbo Tiziana; Palmieri Dario; Pattarozzi Alessandra; Florio Tullio; Viglietto Giuseppe; Trapasso Francesco; Croce Carlo Maria; Fusco Alfredo
The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization.
Journal of biochemistry 2009;145(3):377-85.
2009: Martinez Hoyos J; Ferraro A; Sacchetti S; Keller S; De Martino I; Borbone E; Pallante P; Fedele M; Montanaro D; Esposito F; Cserjesi P; Chiariotti L; Troncone G; Fusco A
HAND1 gene expression is negatively regulated by the High Mobility Group A1 proteins and is drastically reduced in human thyroid carcinomas.
Oncogene 2009;28(6):876-85.
2009: Chiefari Eusebio; Paonessa Francesco; Iiritano Stefania; Le Pera Ilaria; Palmieri Dario; Brunetti Giuseppe; Lupo Angelo; Colantuoni Vittorio; Foti Daniela; Gulletta Elio; De Sarro Giovambattista; Fusco Alfredo; Brunetti Antonio
The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis.
BMC biology 2009;7():24.
2008: Pentimalli Francesca; Palmieri Dario; Pacelli Roberto; Garbi Corrado; Cesari Rossano; Martin Eric; Pierantoni Giovanna Maria; Chieffi Paolo; Croce Carlo Maria; Costanzo Vincenzo; Fedele Monica; Fusco Alfredo
HMGA1 protein is a novel target of the ATM kinase.
European journal of cancer (Oxford, England : 1990) 2008;44(17):2668-79.
2008: Pallante Pierlorenzo; Federico Antonella; Berlingieri Maria Teresa; Bianco Mimma; Ferraro Angelo; Forzati Floriana; Iaccarino Antonino; Russo Maria; Pierantoni Giovanna Maria; Leone Vincenza; Sacchetti Silvana; Troncone Giancarlo; Santoro Massimo; Fusco Alfredo
Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer.
Cancer research 2008;68(16):6770-8.
2008: Chiappetta Gennaro; Ferraro Angelo; Vuttariello Emilia; Monaco Mario; Galdiero Francesca; De Simone Veronica; Califano Daniela; Pallante Pierlorenzo; Botti Gerardo; Pezzullo Luciano; Pierantoni Giovanna Maria; Santoro Massimo; Fusco Alfredo
HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias.
European journal of cancer (Oxford, England : 1990) 2008;44(7):1015-21.
2008: Costa V; Foti D; Paonessa F; Chiefari E; Palaia L; Brunetti G; Gulletta E; Fusco A; Brunetti A
The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-gamma (PPARgamma) and thiazolidinedione-PPARgamma agonists.
Endocrine-related cancer 2008;15(1):325-35.
2008: Visone Rosa; Iuliano Rodolfo; Palmieri Dario; Server Ilter Nurettin; Chiappetta Gennaro; De Martino Ivana; Fedele Monica; Costinean Stefan; Oberyszyn Tatiana M; Kusewitt Donna F; Croce Carlo M; Fusco Alfredo
Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis.
European journal of cancer (Oxford, England : 1990) 2008;44(2):318-25.
2007: Fusco Alfredo; Fedele Monica
Roles of HMGA proteins in cancer.
Nature reviews. Cancer 2007;7(12):899-910.
2007: Berlingieri Maria Teresa; Pallante Pierlorenzo; Sboner Andrea; Barbareschi Mattia; Bianco Mimma; Ferraro Angelo; Mansueto Gelsomina; Borbone Eleonora; Guerriero Eliana; Troncone Giancarlo; Fusco Alfredo
UbcH10 is overexpressed in malignant breast carcinomas.
European journal of cancer (Oxford, England : 1990) 2007;43(18):2729-35.
2007: Motti Maria Letizia; De Marco Carmela; Califano Daniela; De Gisi Silvia; Malanga Donatella; Troncone Giancarlo; Persico Angela; Losito Simona; Fabiani Fernanda; Santoro Massimo; Chiappetta Gennaro; Fusco Alfredo; Viglietto Giuseppe
Loss of p27 expression through RAS-->BRAF-->MAP kinase-dependent pathway in human thyroid carcinomas.
Cell cycle (Georgetown, Tex.) 2007;6(22):2817-25.
2007: Salvatore Giuliana; Nappi Tito Claudio; Salerno Paolo; Jiang Yuan; Garbi Corrado; Ugolini Clara; Miccoli Paolo; Basolo Fulvio; Castellone Maria Domenica; Cirafici Anna Maria; Melillo Rosa Marina; Fusco Alfredo; Bittner Michael L; Santoro Massimo
A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.
Cancer research 2007;67(21):10148-58.
2007: Libertini Silvana; Iacuzzo Irma; Ferraro Angelo; Vitale Mario; Bifulco Maurizio; Fusco Alfredo; Portella Giuseppe
Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells.
Endocrinology 2007;148(11):5186-94.
2007: Visone R; Pallante P; Vecchione A; Cirombella R; Ferracin M; Ferraro A; Volinia S; Coluzzi S; Leone V; Borbone E; Liu C-G; Petrocca F; Troncone G; Calin G A; Scarpa A; Colato C; Tallini G; Santoro M; Croce C M; Fusco A
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
Oncogene 2007;26(54):7590-5.
2007: Pierantoni Giovanna Maria; Esposito Francesco; Giraud Stéphane; Bienvenut Willy Vincent; Diaz Jean Jacques; Fusco Alfredo
Identification of new high mobility group A1 associated proteins.
Proteomics 2007;7(20):3735-42.
2007: De Martino Ivana; Visone Rosa; Palmieri Dario; Cappabianca Paolo; Chieffi Paolo; Forzati Floriana; Barbieri Antonio; Kruhoffer Mogens; Lombardi Gaetano; Fusco Alfredo; Fedele Monica
The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.
Endocrine-related cancer 2007;14(3):875-86.
2007: Visone Rosa; Russo Lucia; Pallante Pierlorenzo; De Martino Ivana; Ferraro Angelo; Leone Vincenza; Borbone Eleonora; Petrocca Fabio; Alder Hansjuerg; Croce Carlo Maria; Fusco Alfredo
MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle.
Endocrine-related cancer 2007;14(3):791-8.
2007: Merolla F; Pentimalli F; Pacelli R; Vecchio G; Fusco A; Grieco M; Celetti A
Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage.
Oncogene 2007;26(42):6167-75.
2007: Santoro Massimo; Fusco Alfredo
New drugs in thyroid cancer.
Arquivos brasileiros de endocrinologia e metabologia 2007;51(5):857-61.
2007: Fusco Alfredo; Santoro Massimo
20 years of RET/PTC in thyroid cancer: clinico-pathological correlations.
Arquivos brasileiros de endocrinologia e metabologia 2007;51(5):731-5.
2007: Cuozzo Concetta; Porcellini Antonio; Angrisano Tiziana; Morano Annalisa; Lee Bongyong; Di Pardo Alba; Messina Samantha; Iuliano Rodolfo; Fusco Alfredo; Santillo Maria R; Muller Mark T; Chiariotti Lorenzo; Gottesman Max E; Avvedimento Enrico V
DNA damage, homology-directed repair, and DNA methylation.
PLoS genetics 2007;3(7):e110.
2007: Chiappetta Gennaro; De Marco Carmela; Quintiero Alfina; Califano Daniela; Gherardi Simona; Malanga Donatella; Scrima Marianna; Montero-Conde Cristina; Cito Letizia; Monaco Mario; Motti Maria Letizia; Pasquinelli Rosa; Agosti Valter; Robledo Mercedes; Fusco Alfredo; Viglietto Giuseppe
Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer.
Endocrine-related cancer 2007;14(2):405-20.
2007: Visconti Roberta; Federico Antonella; Coppola Valeria; Pentimalli Francesca; Berlingieri Maria Teresa; Pallante Pierlorenzo; Kruhoffer Mogens; Orntoft Torben F; Fusco Alfredo
Transcriptional profile of Ki-Ras-induced transformation of thyroid cells.
Cancer investigation 2007;25(4):256-66.
2007: Fedele Monica; De Martino Ivana; Pivonello Rosario; Ciarmiello Andrea; Del Basso De Caro M Laura; Visone Rosa; Palmieri Dario; Pierantoni Giovanna M; Arra Claudio; Schmid Herbert A; Hofland Leo; Lombardi Gaetano; Colao Annamaria; Fusco Alfredo
SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin-secreting pituitary adenomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2738-44.
2007: Casalino Laura; Bakiri Latifa; Talotta Francesco; Weitzman Jonathan B; Fusco Alfredo; Yaniv Moshe; Verde Pasquale
Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription.
The EMBO journal 2007;26(7):1878-90.
2007: Pierantoni Giovanna Maria; Rinaldo Cinzia; Mottolese Marcella; Di Benedetto Anna; Esposito Francesco; Soddu Silvia; Fusco Alfredo
High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.
The Journal of clinical investigation 2007;117(3):693-702.
2007: Berlingieri M T; Pallante P; Guida M; Nappi C; Masciullo V; Scambia G; Ferraro A; Leone V; Sboner A; Barbareschi M; Ferro A; Troncone G; Fusco A
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas.
Oncogene 2007;26(14):2136-40.
2007: De Martino I; Fedele M; Palmieri D; Visone R; Cappabianca P; Wierinckx A; Trouillas J; Fusco A
B-RAF mutations are a rare event in pituitary adenomas.
Journal of endocrinological investigation 2007;30(1):RC1-3.
2007: De Falco Valentina; Castellone Maria Domenica; De Vita Gabriella; Cirafici Anna Maria; Hershman Jerome M; Guerrero Carmen; Fusco Alfredo; Melillo Rosa Marina; Santoro Massimo
RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.
Cancer research 2007;67(1):381-90.
2007: Chiappetta Gennaro; Ferraro Angelo; Botti Gerardo; Monaco Mario; Pasquinelli Rosa; Vuttariello Emilia; Arnaldi Liliane; Di Bonito Maurizio; D'Aiuto Giuseppe; Pierantoni Giovanna Maria; Fusco Alfredo
FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders.
BMC cancer 2007;7():17.
2006: Santoro Massimo; Melillo Rosa Marina; Fusco Alfredo
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(5):645-53.
2006: Fedele Monica; Pierantoni Giovanna Maria; Visone Rosa; Fusco Alfredo
Critical role of the HMGA2 gene in pituitary adenomas.
Cell cycle (Georgetown, Tex.) 2006;5(18):2045-8.
2006: Pierantoni G M; Rinaldo C; Esposito F; Mottolese M; Soddu S; Fusco A
High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity.
Cell death and differentiation 2006;13(9):1554-63.
2006: Vitagliano D; Portella G; Troncone G; Francione A; Rossi C; Bruno A; Giorgini A; Coluzzi S; Nappi T C; Rothstein J L; Pasquinelli R; Chiappetta G; Terracciano D; Macchia V; Melillo R M; Fusco A; Santoro M
Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.
Oncogene 2006;25(39):5467-74.
2006: Trapasso Francesco; Drusco Alessandra; Costinean Stefan; Alder Hansjuerg; Aqeilan Rami I; Iuliano Rodolfo; Gaudio Eugenio; Raso Cinzia; Zanesi Nicola; Croce Carlo M; Fusco Alfredo
Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis.
DNA and cell biology 2006;25(6):376-82.
2006: Fedele Monica; Visone Rosa; De Martino Ivana; Troncone Giancarlo; Palmieri Dario; Battista Sabrina; Ciarmiello Andrea; Pallante Pierlorenzo; Arra Claudio; Melillo Rosa Marina; Helin Kristian; Croce Carlo Maria; Fusco Alfredo
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.
Cancer cell 2006;9(6):459-71.
2006: Pallante P; Visone R; Ferracin M; Ferraro A; Berlingieri M T; Troncone G; Chiappetta G; Liu C G; Santoro M; Negrini M; Croce C M; Fusco A
MicroRNA deregulation in human thyroid papillary carcinomas.
Endocrine-related cancer 2006;13(2):497-508.
2006: Paonessa Francesco; Foti Daniela; Costa Vanessa; Chiefari Eusebio; Brunetti Giuseppe; Leone Francesco; Luciano Francesco; Wu Frank; Lee Amy S; Gulletta Elio; Fusco Alfredo; Brunetti Antonio
Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer.
Cancer research 2006;66(10):5085-93.
2006: Fedele Monica; Fidanza Vincenzo; Battista Sabrina; Pentimalli Francesca; Klein-Szanto Andres J P; Visone Rosa; De Martino Ivana; Curcio Antonio; Morisco Carmine; Del Vecchio Luigi; Baldassarre Gustavo; Arra Claudio; Viglietto Giuseppe; Indolfi Ciro; Croce Carlo M; Fusco Alfredo
Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.
Cancer research 2006;66(5):2536-43.
2006: Fedele Monica; Pierantoni Giovanna Maria; Visone Rosa; Fusco Alfredo
E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression.
Cell division 2006;1():17.
2006: Angrisano Tiziana; Lembo Francesca; Pero Raffaela; Natale Francesco; Fusco Alfredo; Avvedimento Vittorio E; Bruni Carmelo B; Chiariotti Lorenzo
TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters.
Nucleic acids research 2006;34(1):364-72.
2005: Pierantoni Giovanna Maria; Finelli Palma; Valtorta Emanuele; Giardino Daniela; Rodeschini Ornella; Esposito Francesco; Losa Marco; Fusco Alfredo; Larizza Lidia
High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy.
Endocrine-related cancer 2005;12(4):867-74.
2005: Baldassarre Gustavo; Belletti Barbara; Battista Sabrina; Nicoloso Milena S; Pentimalli Francesca; Fedele Monica; Croce Carlo M; Fusco Alfredo
HMGA1 protein expression sensitizes cells to cisplatin-induced cell death.
Oncogene 2005;24(45):6809-19.
2005: Pallante P; Berlingieri M T; Troncone G; Kruhoffer M; Orntoft T F; Viglietto G; Caleo A; Migliaccio I; Decaussin-Petrucci M; Santoro M; Palombini L; Fusco A
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
British journal of cancer 2005;93(4):464-71.
2005: Guida Teresa; Salvatore Giuliana; Faviana Pinuccia; Giannini Riccardo; Garcia-Rostan Ginesa; Provitera Livia; Basolo Fulvio; Fusco Alfredo; Carlomagno Francesca; Santoro Massimo
Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2005;90(8):4703-9.
2005: Foti Daniela; Chiefari Eusebio; Fedele Monica; Iuliano Rodolfo; Brunetti Leonardo; Paonessa Francesco; Manfioletti Guidalberto; Barbetti Fabrizio; Brunetti Arturo; Croce Carlo M; Fusco Alfredo; Brunetti Antonio
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.
Nature medicine 2005;11(7):765-73.
2005: Battista Sabrina; Fedele Monica; Martinez Hoyos Josefina; Pentimalli Francesca; Pierantoni Giovanna Maria; Visone Rosa; De Martino Ivana; Croce Carlo Maria; Fusco Alfredo
High-mobility-group A1 (HMGA1) proteins down-regulate the expression of the recombination activating gene 2 (RAG2).
The Biochemical journal 2005;389(Pt 1):91-7.
2005: Motti Maria Letizia; Califano Daniela; Baldassarre Gustavo; Celetti Angela; Merolla Francesco; Forzati Floriana; Napolitano Maria; Tavernise Barbara; Fusco Alfredo; Viglietto Giuseppe
Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas.
Carcinogenesis 2005;26(6):1021-34.
2005: Fedele Monica; Pentimalli Francesca; Baldassarre Gustavo; Battista Sabrina; Klein-Szanto Andres J P; Kenyon Lawrence; Visone Rosa; De Martino Ivana; Ciarmiello Andrea; Arra Claudio; Viglietto Giuseppe; Croce Carlo M; Fusco Alfredo
Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.
Oncogene 2005;24(21):3427-35.
2005: Melillo Rosa Marina; Castellone Maria Domenica; Guarino Valentina; De Falco Valentina; Cirafici Anna Maria; Salvatore Giuliana; Caiazzo Fiorina; Basolo Fulvio; Giannini Riccardo; Kruhoffer Mogens; Orntoft Torben; Fusco Alfredo; Santoro Massimo
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
The Journal of clinical investigation 2005;115(4):1068-81.
2005: Salvatore Giuliana; Chiappetta Gennaro; Nikiforov Yuri E; Decaussin-Petrucci Myriam; Fusco Alfredo; Carney J Aidan; Santoro Massimo
Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations.
European journal of cancer (Oxford, England : 1990) 2005;41(5):816-21.
2005: Motti Maria Letizia; Califano Daniela; Troncone Giancarlo; De Marco Carmela; Migliaccio Ilenia; Palmieri Emiliano; Pezzullo Luciano; Palombini Lucio; Fusco Alfredo; Viglietto Giuseppe
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization.
The American journal of pathology 2005;166(3):737-49.
2005: Di Vizio Dolores; Cito Letizia; Boccia Angelo; Chieffi Paolo; Insabato Luigi; Pettinato Guido; Motti Maria Letizia; Schepis Filippo; D'Amico Wanda; Fabiani Fernanda; Tavernise Barbara; Venuta Salvatore; Fusco Alfredo; Viglietto Giuseppe
Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.
Oncogene 2005;24(11):1882-94.
2005: Sorrentino Rosanna; Libertini Silvana; Pallante Pier Lorenzo; Troncone Giancarlo; Palombini Lucio; Bavetsias Vassilios; Spalletti-Cernia Daniela; Laccetti Paolo; Linardopoulos Spiros; Chieffi Paolo; Fusco Alfredo; Portella Giuseppe
Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation.
The Journal of clinical endocrinology and metabolism 2005;90(2):928-35.
2005: Fusco Alfredo; Viglietto Giuseppe; Santoro Massimo
A new mechanism of BRAF activation in human thyroid papillary carcinomas.
The Journal of clinical investigation 2005;115(1):20-3.
2004: Santoro M; Carlomagno F; Melillo R M; Fusco A
Dysfunction of the RET receptor in human cancer.
Cellular and molecular life sciences : CMLS 2004;61(23):2954-64.
2004: Santoro Massimo; Melillo Rosa Marina; Carlomagno Francesca; Vecchio Giancarlo; Fusco Alfredo
Minireview: RET: normal and abnormal functions.
Endocrinology 2004;145(12):5448-51.
2004: Chiappetta Gennaro; Botti Gerardo; Monaco Mario; Pasquinelli Rosa; Pentimalli Francesca; Di Bonito Maurizio; D'Aiuto Giuseppe; Fedele Monica; Iuliano Rodolfo; Palmieri Emiliano A; Pierantoni Giovanna Maria; Giancotti Vincenzo; Fusco Alfredo
HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7637-44.
2004: Iuliano Rodolfo; Le Pera Ilaria; Cristofaro Carmela; Baudi Francesco; Arturi Franco; Pallante Pierlorenzo; Martelli Maria Luisa; Trapasso Francesco; Chiariotti Lorenzo; Fusco Alfredo
The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis.
Oncogene 2004;23(52):8432-8.
2004: Trapasso Francesco; Yendamuri Sai; Dumon Kristoffel R; Iuliano Rodolfo; Cesari Rossano; Feig Byron; Seto Robin; Infante Luisa; Ishii Hideshi; Vecchione Andrea; During Matthew J; Croce Carlo M; Fusco Alfredo
Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo.
Carcinogenesis 2004;25(11):2107-14.
2004: Trapasso Francesco; Sarti Manuela; Cesari Rossano; Yendamuri Sai; Dumon Kristoffel R; Aqeilan Rami I; Pentimalli Francesca; Infante Luisa; Alder Hansjuerg; Abe Nobutsugu; Watanabe Takashi; Viglietto Giuseppe; Croce Carlo M; Fusco Alfredo
Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models.
Cancer gene therapy 2004;11(9):633-41.
2004: Martinez Hoyos Josefina; Fedele Monica; Battista Sabrina; Pentimalli Francesca; Kruhoffer Mogens; Arra Claudio; Orntoft Torben F; Croce Carlo Maria; Fusco Alfredo
Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation.
Cancer research 2004;64(16):5728-35.
2004: Motti Maria Letizia; De Marco Carmela; Califano Daniela; Fusco Alfredo; Viglietto Giuseppe
Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer.
Cell cycle (Georgetown, Tex.) 2004;3(8):1074-80.
2004: Melillo Rosa Marina; Cirafici Anna Maria; De Falco Valentina; Bellantoni Marie; Chiappetta Gennaro; Fusco Alfredo; Carlomagno Francesca; Picascia Antonella; Tramontano Donatella; Tallini Giovanni; Santoro Massimo
The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma.
The American journal of pathology 2004;165(2):511-21.
2004: Chiappetta Gennaro; Pentimalli Francesca; Monaco Mario; Fedele Monica; Pasquinelli Rosa; Pierantoni Giovanna Maria; Ribecco Maria Teresa; Santelli Giovanni; Califano Daniela; Pezzullo Luciano; Fusco Alfredo
Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias.
Oncology reports 2004;12(2):239-43.
2004: Castellone Maria D; Guarino Valentina; De Falco Valentina; Carlomagno Francesca; Basolo Fulvio; Faviana Pinuccia; Kruhoffer Mogens; Orntoft Torben; Russell John P; Rothstein Jay L; Fusco Alfredo; Santoro Massimo; Melillo Rosa Marina
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas.
Oncogene 2004;23(35):5958-67.
2004: Carlomagno Francesca; Guida Teresa; Anaganti Suresh; Vecchio Giancarlo; Fusco Alfredo; Ryan Anderson J; Billaud Marc; Santoro Massimo
Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors.
Oncogene 2004;23(36):6056-63.
2004: Vitagliano Donata; Carlomagno Francesca; Motti Maria Letizia; Viglietto Giuseppe; Nikiforov Yuri E; Nikiforova Marina N; Hershman Jerome M; Ryan Anderson J; Fusco Alfredo; Melillo Rosa Marina; Santoro Massimo
Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.
Cancer research 2004;64(11):3823-9.
2004: Donato Giuseppe; Martinez Hoyos Josefina; Amorosi Andrea; Maltese Lorenza; Lavano Angelo; Volpentesta Giorgio; Signorelli Francesco; Pentimalli Francesca; Pallante Pierlorenzo; Ferraro Giuseppe; Tucci Luigi; Signorelli Cosma Damiano; Viglietto Giuseppe; Fusco Alfredo
High mobility group A1 expression correlates with the histological grade of human glial tumors.
Oncology reports 2004;11(6):1209-13.
2004: Castellone Maria Domenica; Celetti Angela; Guarino Valentina; Cirafici Anna Maria; Basolo Fulvio; Giannini Riccardo; Medico Enzo; Kruhoffer Mogens; Orntoft Torben F; Curcio Francesco; Fusco Alfredo; Melillo Rosa Marina; Santoro Massimo
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.
Oncogene 2004;23(12):2188-96.
2003: Pierantoni Giovanna Maria; Battista Sabrina; Pentimalli Francesca; Fedele Monica; Visone Rosa; Federico Antonella; Santoro Massimo; Viglietto Giuseppe; Fusco Alfredo
A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas.
Carcinogenesis 2003;24(12):1861-9.
2003: Pentimalli Francesca; Dentice Monica; Fedele Monica; Pierantoni Giovanna Maria; Cito Letizia; Pallante Pierlorenzo; Santoro Massimo; Viglietto Giuseppe; Dal Cin Paola; Fusco Alfredo
Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2.
Cancer research 2003;63(21):7423-7.
2003: Motti Maria Letizia; Boccia Angelo; Belletti Barbara; Bruni Paola; Troncone Giancarlo; Cito Letizia; Monaco Mario; Chiappetta Gennaro; Baldassarre Gustavo; Palombini Lucio; Fusco Alfredo; Viglietto Giuseppe
Critical role of cyclin D3 in TSH-dependent growth of thyrocytes and in hyperproliferative diseases of the thyroid gland.
Oncogene 2003;22(48):7576-86.
2003: Portella Giuseppe; Pacelli Roberto; Libertini Silvana; Cella Laura; Vecchio Giancarlo; Salvatore Marco; Fusco Alfredo
ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells.
The Journal of clinical endocrinology and metabolism 2003;88(10):5027-32.
2003: Pero Raffaela; Lembo Francesca; Chieffi Paolo; Del Pozzo Giovanna; Fedele Monica; Fusco Alfredo; Bruni Carmelo B; Chiariotti Lorenzo
Translational regulation of a novel testis-specific RNF4 transcript.
Molecular reproduction and development 2003;66(1):1-7.
2003: Pierantoni Giovanna Maria; Santulli Basilia; Caliendo Irene; Pentimalli Francesca; Chiappetta Gennaro; Zanesi Nicola; Santoro Massimo; Bulrich Florencia; Fusco Alfredo
HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia.
International journal of oncology 2003;23(2):363-7.
2003: Battista Sabrina; Pentimalli Francesca; Baldassarre Gustavo; Fedele Monica; Fidanza Vincenzo; Croce Carlo M; Fusco Alfredo
Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1496-8.
2003: Masciullo Valeria; Baldassarre Gustavo; Pentimalli Francesca; Berlingieri Maria Teresa; Boccia Angelo; Chiappetta Gennaro; Palazzo Juan; Manfioletti Guidalberto; Giancotti Vincenzo; Viglietto Giuseppe; Scambia Giovanni; Fusco Alfredo
HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas.
Carcinogenesis 2003;24(7):1191-8.
2003: Pierantoni Giovanna Maria; Agosti Valter; Fedele Monica; Bond Heather; Caliendo Irene; Chiappetta Gennaro; Lo Coco Francesco; Pane Fabrizio; Turco Maria Caterina; Morrone Giovanni; Venuta Salvatore; Fusco Alfredo
High-mobility group A1 proteins are overexpressed in human leukaemias.
The Biochemical journal 2003;372(Pt 1):145-50.
2003: Carlomagno Francesca; Vitagliano Donata; Guida Teresa; Basolo Fulvio; Castellone Maria Domenica; Melillo Rosa Marina; Fusco Alfredo; Santoro Massimo
Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).
The Journal of clinical endocrinology and metabolism 2003;88(4):1897-902.
2003: Baldassarre Gustavo; Battista Sabrina; Belletti Barbara; Thakur Sanjay; Pentimalli Francesca; Trapasso Francesco; Fedele Monica; Pierantoni Giovanna; Croce Carlo M; Fusco Alfredo
Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma.
Molecular and cellular biology 2003;23(7):2225-38.
2003: Santoro M; Melillo R M; Carlomagno F; Castellone M D; Vitagliano D; Guida T; Vecchio G; Fusco A
Genetic alterations in differentiated thyroid cancer: what can be expected for gene expression profiling of thyroid carcinomas.
Annales d'endocrinologie 2003;64(1):62-3.
2003: Visconti Roberta; Schepis Filippo; Iuliano Rodolfo; Pierantoni Giovanna Maria; Zhang Li; Carlomagno Francesca; Battaglia Caterina; Martelli Maria Luisa; Trapasso Francesco; Santoro Massimo; Fusco Alfredo
Cloning and molecular characterization of a novel gene strongly induced by the adenovirus E1A gene in rat thyroid cells.
Oncogene 2003;22(7):1087-97.
2003: Iuliano Rodolfo; Trapasso Francesco; Le Pera Ilaria; Schepis Filippo; Samà Irene; Clodomiro Alessandra; Dumon Kristoffel R; Santoro Massimo; Chiariotti Lorenzo; Viglietto Giuseppe; Fusco Alfredo
An adenovirus carrying the rat protein tyrosine phosphatase eta suppresses the growth of human thyroid carcinoma cell lines in vitro and in vivo.
Cancer research 2003;63(4):882-6.
2003: Castellone Maria Domenica; Cirafici Anna Maria; De Vita Gabriella; De Falco Valentina; Malorni Luca; Tallini Giovanni; Fagin James A; Fusco Alfredo; Melillo Rosa Marina; Santoro Massimo
Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.
Oncogene 2003;22(2):246-55.
2003: Meiboom M; Murua Escobar H; Pentimalli F; Fusco A; Belge G; Bullerdiek J
A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas.
Cytogenetic and genome research 2003;101(2):113-7.
2002: Carlomagno Francesca; Vitagliano Donata; Guida Teresa; Ciardiello Fortunato; Tortora Giampaolo; Vecchio Giancarlo; Ryan Anderson J; Fontanini Gabriella; Fusco Alfredo; Santoro Massimo
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.
Cancer research 2002;62(24):7284-90.
2002: De Nigris F; Cerutti J; Morelli C; Califano D; Chiariotti L; Viglietto G; Santelli G; Fusco A
Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.
British journal of cancer 2002;87(12):1479.
2002: Viglietto Giuseppe; Motti Maria Letizia; Fusco Alfredo
Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization.
Cell cycle (Georgetown, Tex.) 2002;1(6):394-400.
2002: Martelli Maria Luisa; Iuliano Rodolfo; Le Pera Ilaria; Sama' Irene; Monaco Carmen; Cammarota Simona; Kroll Todd; Chiariotti Lorenzo; Santoro Massimo; Fusco Alfredo
Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth.
The Journal of clinical endocrinology and metabolism 2002;87(10):4728-35.
2002: Viglietto Giuseppe; Motti Maria Letizia; Bruni Paola; Melillo Rosa Marina; D'Alessio Amelia; Califano Daniela; Vinci Floriana; Chiappetta Gennaro; Tsichlis Philip; Bellacosa Alfonso; Fusco Alfredo; Santoro Massimo
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
Nature medicine 2002;8(10):1136-44.
2002: Santelli Giovanni; Bartoli Paola Cannada; Giuliano Ada; Porcellini Antonio; Mineo Alba; Barone Maria Vittoria; Busiello Immacolata; Trapasso Francesco; Califano Daniela; Fusco Alfredo
Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium.
Thyroid : official journal of the American Thyroid Association 2002;12(9):765-72.
2002: Santoro Massimo; Melillo Rosa Marina; Carlomagno Francesca; Fusco Alfredo; Vecchio Giancarlo
Molecular mechanisms of RET activation in human cancer.
Annals of the New York Academy of Sciences 2002;963():116-21.
2002: Fusco Alfredo; Chiappetta Gennaro; Hui Pei; Garcia-Rostan Ginesa; Golden Lauren; Kinder Barbara K; Dillon Deborah A; Giuliano Ada; Cirafici Anna Maria; Santoro Massimo; Rosai Juan; Tallini Giovanni
Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer.
The American journal of pathology 2002;160(6):2157-67.
2002: Portella Giuseppe; Scala Stefania; Vitagliano Donata; Vecchio Giancarlo; Fusco Alfredo
ONYX-015, an E1B gene-defective adenovirus, induces cell death in human anaplastic thyroid carcinoma cell lines.
The Journal of clinical endocrinology and metabolism 2002;87(6):2525-31.
2002: Fedele Monica; Battista Sabrina; Kenyon Lawrence; Baldassarre Gustavo; Fidanza Vincenzo; Klein-Szanto Andres J P; Parlow A F; Visone Rosa; Pierantoni Giovanna M; Outwater Eric; Santoro Massimo; Croce Carlo M; Fusco Alfredo
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.
Oncogene 2002;21(20):3190-8.
2002: Berlingieri Maria Teresa; Pierantoni Giovanna M; Giancotti Vincenzo; Santoro Massimo; Fusco Alfredo
Thyroid cell transformation requires the expression of the HMGA1 proteins.
Oncogene 2002;21(19):2971-80.
2002: Curci A; Capasso I; Romano A; Bruni P; Motti M L; Pignata S; D'Aiuto G; Casamassimi A; D'Urso M; Fusco A; Viglietto G
Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples.
International journal of oncology 2002;20(5):963-70.
2002: Finelli Palma; Pierantoni Giovanna Maria; Giardino Daniela; Losa Marco; Rodeschini Ornella; Fedele Monica; Valtorta Emanuele; Mortini Pietro; Croce Carlo M; Larizza Lidia; Fusco Alfredo
The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas.
Cancer research 2002;62(8):2398-405.
2002: de Nigris F; Cerutti J; Morelli C; Califano D; Chiariotti L; Viglietto G; Santelli G; Fusco A
Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.
British journal of cancer 2002;86(6):917-23.
2002: Baldassarre Gustavo; Bruni Paola; Boccia Angelo; Salvatore Giuliana; Melillo Rosa Marina; Motti Maria Letizia; Napolitano Maria; Belletti Barbara; Fusco Alfredo; Santoro Massimo; Viglietto Giuseppe
Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1).
Oncogene 2002;21(11):1739-49.
2002: Carlomagno Francesca; Vitagliano Donata; Guida Teresa; Napolitano Maria; Vecchio Giancarlo; Fusco Alfredo; Gazit Aviv; Levitzki Alexander; Santoro Massimo
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.
Cancer research 2002;62(4):1077-82.
2002: Basolo Fulvio; Giannini Riccardo; Toniolo Antonio; Casalone Rosario; Nikiforova Marina; Pacini Furio; Elisei Rossella; Miccoli Paolo; Berti Piero; Faviana Pinuccia; Fiore Lisa; Monaco Carmen; Pierantoni Giovanna Maria; Fedele Monica; Nikiforov Yuri E; Santoro Massimo; Fusco Alfredo
Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement.
International journal of cancer. Journal international du cancer 2002;97(5):608-14.
2002: Pero Raffaela; Lembo Francesca; Palmieri Emiliano Antonio; Vitiello Carmen; Fedele Monica; Fusco Alfredo; Bruni Carmelo Bruno; Chiariotti Lorenzo
PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription.
The Journal of biological chemistry 2002;277(5):3280-5.
2002: Pierantoni Giovanna Maria; Bulfone Alessandro; Pentimalli Francesca; Fedele Monica; Iuliano Rodolfo; Santoro Massimo; Chiariotti Lorenzo; Ballabio Andrea; Fusco Alfredo
The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.
Biochemical and biophysical research communications 2002;290(3):942-7.
2002: Santoro Massimo; Papotti Mauro; Chiappetta Gennaro; Garcia-Rostan Ginesa; Volante Marco; Johnson Chaline; Camp Robert L; Pentimalli Francesca; Monaco Carmen; Herrero Agustin; Carcangiu Maria Luisa; Fusco Alfredo; Tallini Giovanni
RET activation and clinicopathologic features in poorly differentiated thyroid tumors.
The Journal of clinical endocrinology and metabolism 2002;87(1):370-9.
2002: Chiappetta Gennaro; Toti Paolo; Cetta Francesco; Giuliano Ada; Pentimalli Francesca; Amendola Ida; Lazzi Stefano; Monaco Mario; Mazzuchelli Luca; Tosi Piero; Santoro Massimo; Fusco Alfredo
The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions.
The Journal of clinical endocrinology and metabolism 2002;87(1):364-9.
2002: Basolo Fulvio; Giannini Riccardo; Monaco Carmen; Melillo Rosa Marina; Carlomagno Francesca; Pancrazi Martina; Salvatore Giuliana; Chiappetta Gennaro; Pacini Furio; Elisei Rossella; Miccoli Paolo; Pinchera Aldo; Fusco Alfredo; Santoro Massimo
Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma.
The American journal of pathology 2002;160(1):247-54.
2001: Basolo F; Molinaro E; Agate L; Pinchera A; Pollina L; Chiappetta G; Monaco C; Santoro M; Fusco A; Miccoli P; Elisei R; Capezzone M; Pacini F
RET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(5):599-604.
2001: Barone M V; Sepe L; Melillo R M; Mineo A; Santelli G; Monaco C; Castellone M D; Tramontano D; Fusco A; Santoro M
RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.
Oncogene 2001;20(48):6973-82.
2001: Manié S; Santoro M; Fusco A; Billaud M
The RET receptor: function in development and dysfunction in congenital malformation.
Trends in genetics : TIG 2001;17(10):580-9.
2001: Pero R; Lembo F; Di Vizio D; Boccia A; Chieffi P; Fedele M; Pierantoni G M; Rossi P; Iuliano R; Santoro M; Viglietto G; Bruni C B; Fusco A; Chiariotti L
RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors.
The American journal of pathology 2001;159(4):1225-30.
2001: Fedele M; Battista S; Manfioletti G; Croce C M; Giancotti V; Fusco A
Role of the high mobility group A proteins in human lipomas.
Carcinogenesis 2001;22(10):1583-91.
2001: Pierantoni G M; Fedele M; Pentimalli F; Benvenuto G; Pero R; Viglietto G; Santoro M; Chiariotti L; Fusco A
High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth.
Oncogene 2001;20(43):6132-41.
2001: Baldassarre G; Fedele M; Battista S; Vecchione A; Klein-Szanto A J; Santoro M; Waldmann T A; Azimi N; Croce C M; Fusco A
Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7970-5.
2001: Melillo R M; Santoro M; Ong S H; Billaud M; Fusco A; Hadari Y R; Schlessinger J; Lax I
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.
Molecular and cellular biology 2001;21(13):4177-87.
2001: Iuliano R; Trapasso F; Samà I; Le Pera I; Martelli M L; Lembo F; Santoro M; Viglietto G; Chiariotti L; Fusco A
Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of syntenin.
FEBS letters 2001;500(1-2):41-4.
2001: Fedele M; Pierantoni G M; Berlingieri M T; Battista S; Baldassarre G; Munshi N; Dentice M; Thanos D; Santoro M; Viglietto G; Fusco A
Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells.
Cancer research 2001;61(11):4583-90.
2001: Melillo R M; Pierantoni G M; Scala S; Battista S; Fedele M; Stella A; De Biasio M C; Chiappetta G; Fidanza V; Condorelli G; Santoro M; Croce C M; Viglietto G; Fusco A
Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation.
Molecular and cellular biology 2001;21(7):2485-95.
2001: de Nigris F; Mega T; Berger N; Barone M V; Santoro M; Viglietto G; Verde P; Fusco A
Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation.
Cancer research 2001;61(5):2267-75.
2001: Monaco C; Visconti R; Barone M V; Pierantoni G M; Berlingieri M T; De Lorenzo C; Mineo A; Vecchio G; Fusco A; Santoro M
The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane.
Oncogene 2001;20(5):599-608.
2001: Salvatore D; Melillo R M; Monaco C; Visconti R; Fenzi G; Vecchio G; Fusco A; Santoro M
Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B.
Cancer research 2001;61(4):1426-31.
2001: Scala S; Portella G; Vitagliano D; Ledent C; Chiappetta G; Giancotti V; Dumont J; Fusco A
HMGI-C gene expression is not required for in vivo thyroid cell transformation.
Carcinogenesis 2001;22(2):251-6.
2001: Melillo R M; Carlomagno F; De Vita G; Formisano P; Vecchio G; Fusco A; Billaud M; Santoro M
The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.
Oncogene 2001;20(2):209-18.
2001: Chiappetta G; Manfioletti G; Pentimalli F; Abe N; Di Bonito M; Vento M T; Giuliano A; Fedele M; Viglietto G; Santoro M; Watanabe T; Giancotti V; Fusco A
High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases.
International journal of cancer. Journal international du cancer 2001;91(2):147-51.
2001: Portella G; Borselli C; Santoro M; Gerbasio D; D'Armiento M R; Dumont J E; Ledent C; Rothstein J L; Vecchio G; Fusco A
Human papilloma virus 16 E7 oncogene does not cooperate with RET/PTC 3 oncogene in the neoplastic transformation of thyroid cells in transgenic mice.
Oncology research 2001;12(8):347-54.
2000: Papotti M; Volante M; Giuliano A; Fassina A; Fusco A; Bussolati G; Santoro M; Chiappetta G
RET/PTC activation in hyalinizing trabecular tumors of the thyroid.
The American journal of surgical pathology 2000;24(12):1615-21.
2000: Trapasso F; Iuliano R; Boccia A; Stella A; Visconti R; Bruni P; Baldassarre G; Santoro M; Viglietto G; Fusco A
Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1).
Molecular and cellular biology 2000;20(24):9236-46.
2000: Russell J P; Powell D J; Cunnane M; Greco A; Portella G; Santoro M; Fusco A; Rothstein J L
The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium.
Oncogene 2000;19(50):5729-35.
2000: Chiappetta G; Tallini G; De Biasio M C; Pentimalli F; de Nigris F; Losito S; Fedele M; Battista S; Verde P; Santoro M; Fusco A
FRA-1 expression in hyperplastic and neoplastic thyroid diseases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(11):4300-6.
2000: Iuliano R; Trapasso F; Stella A; Le Pera I; Melillo R M; Bruni P; Baldassarre G; Chiariotti L; Santoro M; Viglietto G; Fusco A
Pivotal role of the RB family proteins in in vitro thyroid cell transformation.
Experimental cell research 2000;260(2):257-67.
2000: Baldassarre G; Boccia A; Bruni P; Sandomenico C; Barone M V; Pepe S; Angrisano T; Belletti B; Motti M L; Fusco A; Viglietto G
Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(10):517-26.
2000: Salvatore D; Barone M V; Salvatore G; Melillo R M; Chiappetta G; Mineo A; Fenzi G; Vecchio G; Fusco A; Santoro M
Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins.
The Journal of clinical endocrinology and metabolism 2000;85(10):3898-907.
2000: Martelli M L; Miano M G; Battaglia C; Trapasso F; Stella A; Iuliano R; Visconti R; Fagin J A; Santoro M; Fusco A
The highly malignant phenotype of anaplastic thyroid carcinoma cell lines is recessive.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(4):515-21.
2000: De Vita G; Berlingieri M T; Visconti R; Castellone M D; Viglietto G; Baldassarre G; Zannini M; Bellacosa A; Tsichlis P N; Fusco A; Santoro M
Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects.
Cancer research 2000;60(14):3916-20.
2000: De Vita G; Melillo R M; Carlomagno F; Visconti R; Castellone M D; Bellacosa A; Billaud M; Fusco A; Tsichlis P N; Santoro M
Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.
Cancer research 2000;60(14):3727-31.
2000: Bruni P; Boccia A; Baldassarre G; Trapasso F; Santoro M; Chiappetta G; Fusco A; Viglietto G
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1.
Oncogene 2000;19(28):3146-55.
2000: Santulli B; Kazmierczak B; Napolitano R; Caliendo I; Chiappetta G; Rippe V; Bullerdiek J; Fusco A
A 12q13 translocation involving the HMGI-C gene in richter transformation of a chronic lymphocytic leukemia.
Cancer genetics and cytogenetics 2000;119(1):70-3.
2000: Scala S; Portella G; Fedele M; Chiappetta G; Fusco A
Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4256-61.
2000: Viglietto G; Dolci S; Bruni P; Baldassarre G; Chiariotti L; Melillo R M; Salvatore G; Chiappetta G; Sferratore F; Fusco A; Santoro M
Glial cell line-derived neutrotrophic factor and neurturin can act as paracrine growth factors stimulating DNA synthesis of Ret-expressing spermatogonia.
International journal of oncology 2000;16(4):689-94.
2000: Fedele M; Benvenuto G; Pero R; Majello B; Battista S; Lembo F; Vollono E; Day P M; Santoro M; Lania L; Bruni C B; Fusco A; Chiariotti L
A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor.
The Journal of biological chemistry 2000;275(11):7894-901.
2000: Villone G; De Vita G; Chieffi P; Picascia A; Stanzione R; Santoro M; Fusco A; Tramontano D
Association between the expression of E1A oncogene and increased sensitivity to growth inhibition induced by sustained levels of cAMP in rat thyroid cells.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(3):286-93.
2000: Giannini R; Salvatore G; Monaco C; Sferratore F; Pollina L; Pacini F; Basolo F; Fusco A; Santoro M
Identification of a novel subtype of H4-RET rearrangement in a thyroid papillary carcinoma and lymph node metastasis.
International journal of oncology 2000;16(3):485-9.
2000: Santoro M; Thomas G A; Vecchio G; Williams G H; Fusco A; Chiappetta G; Pozcharskaya V; Bogdanova T I; Demidchik E P; Cherstvoy E D; Voscoboinik L; Tronko N D; Carss A; Bunnell H; Tonnachera M; Parma J; Dumont J E; Keller G; Höfler H; Williams E D
Gene rearrangement and Chernobyl related thyroid cancers.
British journal of cancer 2000;82(2):315-22.
1999: Santoro M; Carlomagno F; Melillo R M; Billaud M; Vecchio G; Fusco A
Molecular mechanisms of RET activation in human neoplasia.
Journal of endocrinological investigation 1999;22(10):811-9.
1999: Baldassarre G; Barone M V; Belletti B; Sandomenico C; Bruni P; Spiezia S; Boccia A; Vento M T; Romano A; Pepe S; Fusco A; Viglietto G
Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation.
Oncogene 1999;18(46):6241-51.
1999: Thomas G A; Bunnell H; Cook H A; Williams E D; Nerovnya A; Cherstvoy E D; Tronko N D; Bogdanova T I; Chiappetta G; Viglietto G; Pentimalli F; Salvatore G; Fusco A; Santoro M; Vecchio G
High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant.
The Journal of clinical endocrinology and metabolism 1999;84(11):4232-8.
1999: Rippe V; Belge G; Meiboom M; Kazmierczak B; Fusco A; Bullerdiek J
A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors.
Genes, chromosomes & cancer 1999;26(3):229-36.
1999: Battista S; Fidanza V; Fedele M; Klein-Szanto A J; Outwater E; Brunner H; Santoro M; Croce C M; Fusco A
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.
Cancer research 1999;59(19):4793-7.
1999: Baldassarre G; Belletti B; Bruni P; Boccia A; Trapasso F; Pentimalli F; Barone M V; Chiappetta G; Vento M T; Spiezia S; Fusco A; Viglietto G
Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells.
The Journal of clinical investigation 1999;104(7):865-74.
1999: Santelli G; Califano D; Chiappetta G; Vento M T; Bartoli P C; Zullo F; Trapasso F; Viglietto G; Fusco A
Thymosin beta-10 gene overexpression is a general event in human carcinogenesis.
The American journal of pathology 1999;155(3):799-804.
1999: Belletti B; Ferraro P; Arra C; Baldassarre G; Bruni P; Staibano S; De Rosa G; Salvatore G; Fusco A; Persico M G; Viglietto G
Modulation of in vivo growth of thyroid tumor-derived cell lines by sense and antisense vascular endothelial growth factor gene.
Oncogene 1999;18(34):4860-9.
1999: Viglietto G; Califano D; Bruni P; Baldassarre G; Vento M T; Belletti B; Fedele M; Santelli G; Boccia A; Manzo G; Santoro M; Fusco A
Regulation of thymosin beta10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(6):597-607.
1999: Basolo F; Fiore L; Fusco A; Giannini R; Albini A; Merlo G R; Fontanini G; Conaldi P G; Toniolo A
Potentiation of the malignant phenotype of the undifferentiated ARO thyroid cell line by insertion of the bcl-2 gene.
International journal of cancer. Journal international du cancer 1999;81(6):956-62.
1999: Trapasso F; Iuliano R; Chiefari E; Arturi F; Stella A; Filetti S; Fusco A; Russo D
Iodide symporter gene expression in normal and transformed rat thyroid cells.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(5):447-51.
1999: Santoro M; Melillo R M; Carlomagno F; Visconti R; De Vita G; Salvatore G; Fusco A; Vecchio G
Different mutations of the RET gene cause different human tumoral diseases.
Biochimie 1999;81(4):397-402.
1999: Melillo R M; Barone M V; Lupoli G; Cirafici A M; Carlomagno F; Visconti R; Matoskova B; Di Fiore P P; Vecchio G; Fusco A; Santoro M
Ret-mediated mitogenesis requires Src kinase activity.
Cancer research 1999;59(5):1120-6.
1999: Portella G; Vitagliano D; Borselli C; Melillo R M; Salvatore D; Rothstein J L; Vecchio G; Fusco A; Santoro M
Human N-ras, TRK-T1, and RET/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and the proliferation of thyroid epithelial cells.
Oncology research 1999;11(9):421-7.
1998: Chappuis-Flament S; Pasini A; De Vita G; Ségouffin-Cariou C; Fusco A; Attié T; Lenoir G M; Santoro M; Billaud M
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.
Oncogene 1998;17(22):2851-61.
1998: Powell D J; Russell J; Nibu K; Li G; Rhee E; Liao M; Goldstein M; Keane W M; Santoro M; Fusco A; Rothstein J L
The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids.
Cancer research 1998;58(23):5523-8.
1998: Kazmierczak B; Dal Cin P; Wanschura S; Borrmann L; Fusco A; Van den Berghe H; Bullerdiek J
HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors.
Genes, chromosomes & cancer 1998;23(4):279-85.
1998: Martelli M L; Trapasso F; Bruni P; Berlingieri M T; Battaglia C; Vento M T; Belletti B; Iuliano R; Santoro M; Viglietto G; Fusco A
Protein tyrosine phosphatase-eta expression is upregulated by the PKA-dependent and is downregulated by the PKC-dependent pathways in thyroid cells.
Experimental cell research 1998;245(1):195-202.
1998: de Nigris F; Visconti R; Cerutti J; Califano D; Mineo A; Santoro M; Santelli G; Fusco A
Overexpression of the HIP gene coding for a heparin/heparan sulfate-binding protein in human thyroid carcinomas.
Cancer research 1998;58(20):4745-51.
1998: Scala S; Bruni P; Lo Muzio L; Mignogna M; Viglietto G; Fusco A
Novel mutation of the PTEN gene in an Italian Cowden's disease kindred.
International journal of oncology 1998;13(4):665-8.
1998: Chiappetta G; Tallini G; De Biasio M C; Manfioletti G; Martinez-Tello F J; Pentimalli F; de Nigris F; Mastro A; Botti G; Fedele M; Berger N; Santoro M; Giancotti V; Fusco A
Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma.
Cancer research 1998;58(18):4193-8.
1998: Carlomagno F; Melillo R M; Visconti R; Salvatore G; De Vita G; Lupoli G; Yu Y; Jing S; Vecchio G; Fusco A; Santoro M
Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease.
Endocrinology 1998;139(8):3613-9.
1998: Fedele M; Berlingieri M T; Scala S; Chiariotti L; Viglietto G; Rippel V; Bullerdiek J; Santoro M; Fusco A
Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts.
Oncogene 1998;17(4):413-8.
1998: Battista S; de Nigris F; Fedele M; Chiappetta G; Scala S; Vallone D; Pierantoni G M; Mega T; Santoro M; Viglietto G; Verde P; Fusco A;
Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo.
Oncogene 1998;17(3):377-85.
1998: Casamassimi A; Miano M G; Porcellini A; De Vita G; de Nigris F; Zannini M; Di Lauro R; Russo T; Avvedimento V E; Fusco A
p53 genes mutated in the DNA binding site or at a specific COOH-terminal site exert divergent effects on thyroid cell growth and differentiation.
Cancer research 1998;58(13):2888-94.
1998: Santoro M; Melillo R M; Carlomagno F; Visconti R; De Vita G; Salvatore G; Lupoli G; Fusco A; Vecchio G
Molecular biology of the MEN2 gene.
Journal of internal medicine 1998;243(6):505-8.
1998: Chiariello M; Visconti R; Carlomagno F; Melillo R M; Bucci C; de Franciscis V; Fox G M; Jing S; Coso O A; Gutkind J S; Fusco A; Santoro M
Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.
Oncogene 1998;16(19):2435-45.
1998: Califano D; Monaco C; Santelli G; Giuliano A; Veronese M L; Berlingieri M T; de Franciscis V; Berger N; Trapasso F; Santoro M; Viglietto G; Fusco A
Thymosin beta-10 gene overexpression correlated with the highly malignant neoplastic phenotype of transformed thyroid cells in vivo and in vitro.
Cancer research 1998;58(4):823-8.
1998: Chiariotti L; Benvenuto G; Fedele M; Santoro M; Simeone A; Fusco A; Bruni C B
Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3.
Genomics 1998;47(2):258-65.
1998: De Vita G; Zannini M; Cirafici A M; Melillo R M; Di Lauro R; Fusco A; Santoro M
Expression of the RET/PTC1 oncogene impairs the activity of TTF-1 and Pax-8 thyroid transcription factors.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(1):97-103.
1998: Portella G; Vitagliano D; Li Z; Sferratore F; Santoro M; Vecchio G; Fusco A
TPA induces a block of differentiation and increases the susceptibility to neoplastic transformation of a rat thyroid epithelial cell line.
Oncology research 1998;10(9):441-7.
1997: Fiore L; Pollina L E; Fontanini G; Casalone R; Berlingieri M T; Giannini R; Pacini F; Miccoli P; Toniolo A; Fusco A; Basolo F
Cytokine production by a new undifferentiated human thyroid carcinoma cell line, FB-1.
The Journal of clinical endocrinology and metabolism 1997;82(12):4094-100.
1997: Viglietto G; Romano A; Manzo G; Chiappetta G; Paoletti I; Califano D; Galati M G; Mauriello V; Bruni P; Lago C T; Fusco A; Persico M G
Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization.
Oncogene 1997;15(22):2687-98.
1997: Visconti R; Cerutti J; Battista S; Fedele M; Trapasso F; Zeki K; Miano M P; de Nigris F; Casalino L; Curcio F; Santoro M; Fusco A
Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.
Oncogene 1997;15(16):1987-94.
1997: Belge G; Garcia E; Rippe V; Fusco A; Bartnitzke S; Bullerdiek J
Breakpoints of 19q13 translocations of benign thyroid tumors map within a 400 kilobase region.
Genes, chromosomes & cancer 1997;20(2):201-3.
1997: Vallone D; Battista S; Pierantoni G M; Fedele M; Casalino L; Santoro M; Viglietto G; Fusco A; Verde P
Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product.
The EMBO journal 1997;16(17):5310-21.
1997: Zhang L; Martelli M L; Battaglia C; Trapasso F; Tramontano D; Viglietto G; Porcellini A; Santoro M; Fusco A
Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase.
Experimental cell research 1997;235(1):62-70.
1997: Cirafici A M; Salvatore G; De Vita G; Carlomagno F; Dathan N A; Visconti R; Melillo R M; Fusco A; Santoro M
Only the substitution of methionine 918 with a threonine and not with other residues activates RET transforming potential.
Endocrinology 1997;138(4):1450-5.
1997: Carlomagno F; Salvatore G; Cirafici A M; De Vita G; Melillo R M; de Franciscis V; Billaud M; Fusco A; Santoro M
The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype.
Cancer research 1997;57(3):391-5.
1997: Wirtschafter A; Schmidt R; Rosen D; Kundu N; Santoro M; Fusco A; Multhaupt H; Atkins J P; Rosen M R; Keane W M; Rothstein J L
Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis.
The Laryngoscope 1997;107(1):95-100.

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