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Alfredo Fusco

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Daniela D'Angelo; Maurizio D'Incalci; Francesco Esposito; Roberta Frapolli; Roberto Pacelli; Dario Palmieri; Sarah Uboldi; Eleonora Borbone; Alfredo Fusco
The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin.
pierlorenzo pallante; Danilo Rocco; Montserrat Sanchez-Cespedes; Romina Sepe; Claudio Bellevicine; Maria Teresa Berlingieri; Lorenzo Chiariotti; Antonella Federico; Alfredo Fusco; Mario Galgani; Umberto Malapelle; Giancarlo Troncone
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
Teresa Valentino; Michela Vitiello; Claudio Arra; Lorenzo Chiariotti; Paolo Chieffi; Alfredo Fusco; Giuseppe Palma; Dario Palmieri; Antonio Simeone; Monica Fedele
Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene.

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2013: Daniela D'Angelo; Maurizio D'Incalci; Francesco Esposito; Roberta Frapolli; Roberto Pacelli; Dario Palmieri; Sarah Uboldi; Eleonora Borbone; Alfredo Fusco
The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin.
European journal of cancer (Oxford, England : 1990) 2013;49(5):1142-51.
2013: pierlorenzo pallante; Danilo Rocco; Montserrat Sanchez-Cespedes; Romina Sepe; Claudio Bellevicine; Maria Teresa Berlingieri; Lorenzo Chiariotti; Antonella Federico; Alfredo Fusco; Mario Galgani; Umberto Malapelle; Giancarlo Troncone
UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.
European journal of cancer (Oxford, England : 1990) 2013;49(5):1117-26.
2013: Teresa Valentino; Michela Vitiello; Claudio Arra; Lorenzo Chiariotti; Paolo Chieffi; Alfredo Fusco; Giuseppe Palma; Dario Palmieri; Antonio Simeone; Monica Fedele
Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene.
Journal of cellular physiology 2013;228(3):646-53.
2013: Francesco Paduano; Camillo Palmieri; Nicola Perrotti; Francesco Trapasso; Valter Agosti; Anna Bilotta; Vincenzo Dattilo; Alfredo Fusco; Eugenio Gaudio; Miranda Menniti; Domenico Narciso; Rodolfo Iuliano
Protein tyrosine phosphatase PTPRJ is negatively regulated by microRNA-328.
The FEBS journal 2013;280(2):401-12.
2012: Marianna Colamaio; Carlo Maria Croce; Myriam Decaussin-Petrucci; Sabrina Battista; Eleonora Borbone; Gaetano Calì; Lucio Nitsch; pierlorenzo pallante; Daniela Sarnataro; Alfredo Fusco
Let-7a down-regulation plays a role in thyroid neoplasias of follicular histotype affecting cell adhesion and migration through its ability to target the FXYD5 (Dysadherin) gene.
The Journal of clinical endocrinology and metabolism 2012;97(11):E2168-78.
2012: Francesco Paduano; Camillo Palmieri; Nicola Perrotti; Cinzia Raso; Marina Sala; Giuseppe Scala; Giuseppe Viglietto; Valter Agosti; Stefano Alcaro; Anna Artese; Anna Bilotta; Pietro Campiglia; Alfonso Carotenuto; Carlo M Croce; Giovanni Cuda; Alfredo Fusco; Marco Gaspari; Eugenio Gaudio; Isabel Gomez-Monterrey; Enrico Iaccino; Rodolfo Iuliano; Graziella Mangone; Domenico Narciso; Ettore Novellino; Francesco Ortuso; Francesco Trapasso
Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity.
ACS chemical biology 2012;7(10):1666-76.
2012: Vincenza Leone; pierlorenzo pallante; Carlo Maria Croce; Daniela D'Angelo; Alfredo Fusco
Thyrotropin regulates thyroid cell proliferation by up-regulating miR-23b and miR-29b that target SMAD3.
The Journal of clinical endocrinology and metabolism 2012;97(9):3292-301.
2012: Dario Palmieri; Jacqueline Trouillas; T Valentino; Anne Wierinckx; Daniela D'Angelo; Ivana De Martino; Monica Fedele; Angelo Ferraro; Alfredo Fusco
Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis.
Oncogene 2012;31(34):3857-65.
2012: Daniela D'Angelo; Monica Fedele; Carlo Maria Croce; Paula Mussnich; Dario Palmieri; gerald raverot; Magali Roche; Jacqueline Trouillas; Anne Wierinckx; Alfredo Fusco
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.
The Journal of clinical endocrinology and metabolism 2012;97(7):E1128-38.
2012: Raffaela Pero; Teresa Valentino; Simon D Wagner; Tiziana Angrisano; Claudio Arra; Lorenzo Chiariotti; Carlo M Croce; Luigi Del Vecchio; Antonella Federico; Renato Franco; Alfredo Fusco; Simona Keller; Andres J Klein-Szanto; Francesca Lembo; Donatella Montanaro; Dario Palmieri; Vasiliki Papadopoulou; Monica Fedele
POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation.
The Journal of biological chemistry 2012;287(22):18308-17.
2012: Floriana Forzati; Monica Fedele; Antonella Federico; pierlorenzo pallante; Alfredo Fusco
Tumor suppressor activity of CBX7 in lung carcinogenesis.
Cell cycle (Georgetown, Tex.) 2012;11(10):1888-91.
2012: Francesco Esposito; Antonella Federico; pierlorenzo pallante; Giovanna Maria Pierantoni; Mara Tornincasa; Eleonora Borbone; Alfredo Fusco
Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2.
The Journal of clinical endocrinology and metabolism 2012;97(5):E710-8.
2012: Dario Palmieri; Giovanna Maria Pierantoni; Jacqueline Trouillas; Teresa Valentino; Michela Vitiello; Anne Wierinckx; Paolo Cappabianca; Annamaria Colao; Ivana De Martino; Francesco Esposito; Alfredo Fusco; Gaetano Lombardi; Monica Fedele
PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis.
Endocrine-related cancer 2012;19(2):123-35.
2012: Floriana Forzati; Adele Abbate; Claudio Arra; Francesco Esposito; Monica Fedele; Antonella Federico; Umberto Malapelle; pierlorenzo pallante; Giuseppe Palma; Marzia Scarfò; Romina Sepe; Giancarlo Troncone; Alfredo Fusco
CBX7 is a tumor suppressor in mice and humans.
The Journal of clinical investigation 2012;122(2):612-23.
2012: Chiara Luise; Francesco Merolla; Simona Paladino; Daniela Sarnataro; Alfredo Fusco; Vincenza Leone; Angela Celetti
Identification of sumoylation sites in CCDC6, the first identified RET partner gene in papillary thyroid carcinoma, uncovers a mode of regulating CCDC6 function on CREB1 transcriptional activity.
PloS one 2012;7(11):e49298.
2012: Francesco Merolla; Mark T Muller; Roberto Pacelli; Alfredo Fusco; Chiara Luise; Angela Celetti
Loss of CCDC6, the first identified RET partner gene, affects pH2AX S139 levels and accelerates mitotic entry upon DNA damage.
PloS one 2012;7(5):e36177.
2011: Marianna Colamaio; Antonella Federico; pierlorenzo pallante; Lucia Russo; Giancarlo Troncone; Sabrina Battista; Mimma Bianco; Eleonora Borbone; Daniela Califano; Gennaro Chiappetta; Alfredo Fusco
miR-191 down-regulation plays a role in thyroid follicular tumors through CDK6 targeting.
The Journal of clinical endocrinology and metabolism 2011;96(12):E1915-24.
2011: Vincenza Leone; pierlorenzo pallante; Ileana Rubio; Massimo Santoro; Carlo Maria Croce; Daniela D'Angelo; Angelo Ferraro; Alfredo Fusco
A TSH-CREB1-microRNA loop is required for thyroid cell growth.
Molecular endocrinology (Baltimore, Md.) 2011;25(10):1819-30.
2011: Vincenza Leone; Geraldo Medeiros-Neto; pierlorenzo pallante; Ileana Rubio; Marianna Colamaio; Daniela D'Angelo; Paula Mussnich de Freitas; Antonella Federico; Alfredo Fusco
MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha.
The Journal of clinical endocrinology and metabolism 2011;96(9):E1388-98.
2011: Dario Palmieri; I Postiglione; T Valentino; Roberto Pacelli; Carlo M Croce; Daniela D'Angelo; Ivana De Martino; Monica Fedele; Alfredo Fusco
HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents.
Oncogene 2011;30(27):3024-35.
2011: Paolo Salerno; Ginesa Garcia-Rostan; Sara Piccinin; Tammaro Claudio Bencivenga; Gennaro Di Maro; Claudio Doglioni; Fulvio Basolo; Roberta Maestro; Alfredo Fusco; Massimo Santoro; Giuliana Salvatore
TWIST1 plays a pleiotropic role in determining the anaplastic thyroid cancer phenotype.
The Journal of clinical endocrinology and metabolism 2011;96(5):E772-81.
2011: Eleonora Borbone; Giancarlo Troncone; Angelo Ferraro; Zuzana Jasencakova; Lovorka Stojic; Francesco Esposito; Nadine Hornig; Alfredo Fusco; Valerio Orlando
Enhancer of zeste homolog 2 overexpression has a role in the development of anaplastic thyroid carcinomas.
The Journal of clinical endocrinology and metabolism 2011;96(4):1029-38.
2011: Tiziana de Cristofaro; Tina Di Palma; Angelo Ferraro; Alessia Corrado; Valeria Lucci; renato franco; Alfredo Fusco; Mariastella Zannini
TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma.
European journal of cancer (Oxford, England : 1990) 2011;47(6):926-33.
2011: Eusebio Chiefari; Sinan Tanyolaç; Francesco Paonessa; Clive R Pullinger; C Capula; Stefania Iiritano; Tommaso Mazza; Michele Forlin; Alfredo Fusco; Vincent Durlach; Anne Durlach; Mary J Malloy; John P Kane; Steven W Heiner; Mirella Filocamo; Daniela Foti; Ira D Goldfine; Antonio Brunetti
Functional variants of the HMGA1 gene and type 2 diabetes mellitus.
JAMA : the journal of the American Medical Association 2011;305(9):903-12.
2011: Tiziana Angrisano; S Sacchetti; F Natale; aniello Cerrato; Raffaela Pero; S Keller; S Peluso; B Perillo; Vittorio E Avvedimento; Alfredo Fusco; Carmelo B Bruni; Francesca Lembo; Massimo Santoro; Lorenzo Chiariotti
Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells.
Nucleic acids research 2011;39(6):1993-2006.
2011: Monica Fedele; Rosa Visone; Ivana De Martino; Dario Palmieri; Teresa Valentino; Francesco Esposito; Andres Klein-Szanto; Claudio Arra; Andrea Ciarmiello; Carlo M Croce; Alfredo Fusco
Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice.
European journal of cancer (Oxford, England : 1990) 2011;47(3):470-8.
2011: D Frezzetti; M De Menna; P Zoppoli; C Guerra; Angelo Ferraro; A M Bello; P De Luca; C Calabrese; Alfredo Fusco; M Ceccarelli; Massimo Zollo; M Barbacid; R Di Lauro; G De Vita
Upregulation of miR-21 by Ras in vivo and its role in tumor growth.
Oncogene 2011;30(3):275-86.
2010: Rodolfo Iuliano; Dario Palmieri; Huiling He; Angela Iervolino; Eleonora Borbone; pierlorenzo pallante; Alessandra Cianflone; Rebecca Nagy; Hansjuerg Alder; George A Calin; Francesco Trapasso; Carla Giordano; Carlo M Croce; ALBERT DE LA CHAPELLE; Alfredo Fusco
Role of PTPRJ genotype in papillary thyroid carcinoma risk.
Endocrine-related cancer 2010;17(4):1001-6.
2010: Monica Fedele; Dario Palmieri; Alfredo Fusco
HMGA2: A pituitary tumour subtype-specific oncogene?
Molecular and cellular endocrinology 2010;326(1-2):19-24.
2010: pierlorenzo pallante; Luigi Terracciano; Vincenza Carafa; Sandra Schneider; Inti Zlobec; Alessandro Lugli; Mimma Bianco; Angelo Ferraro; Silvana Sacchetti; Giancarlo Troncone; Alfredo Fusco; Luigi Tornillo
The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients.
European journal of cancer (Oxford, England : 1990) 2010;46(12):2304-13.
2010: Vincenza Leone; Gelsomina Mansueto; Giovanna Maria Pierantoni; M Tornincasa; Francesco Merolla; aniello Cerrato; Massimo Santoro; Michele Grieco; A Scaloni; Angela Celetti; Alfredo Fusco
CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1.
Oncogene 2010;29(30):4341-51.
2010: Francesco Esposito; Mara Tornincasa; Paolo Chieffi; Ivana De Martino; Giovanna Maria Pierantoni; Alfredo Fusco
High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene.
Cancer research 2010;70(13):5379-88.
2010: Eliana Guerriero; Angelo Ferraro; Doriana Desiderio; pierlorenzo pallante; Maria Teresa Berlingieri; Antonino Iaccarino; Emiliano A Palmieri; Lucio Palombini; Alfredo Fusco; Giancarlo Troncone
UbcH10 expression on thyroid fine-needle aspirates.
Cancer cytopathology 2010;118(3):157-65.
2010: Monica Fedele; Alfredo Fusco
Role of the high mobility group A proteins in the regulation of pituitary cell cycle.
Journal of molecular endocrinology 2010;44(6):309-18.
2010: Gelsomina Mansueto; pierlorenzo pallante; Giancarlo Troncone; Antonino Iaccarino; Mimma Bianco; Francesco Esposito; Angelo Ferraro; Floriana Forzati; Alfredo Fusco
Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein.
Genes & cancer 2010;1(3):210-24.
2010: Simona Keller; marco sarchiapone; Federica Zarrilli; Alja Videtic; Angelo Ferraro; Vladimir Carli; Silvana Sacchetti; Francesca Lembo; Antonella Angiolillo; Nikolina Jovanovic; Francesco Pisanti; Rossella Tomaiuolo; Antonella Monticelli; Joze Balazic; Alec Roy; Andrej Marusic; Sergio Cocozza; Alfredo Fusco; Carmelo B Bruni; Giuseppe Castaldo; Lorenzo Chiariotti
Increased BDNF promoter methylation in the Wernicke area of suicide subjects.
Archives of general psychiatry 2010;67(3):258-67.
2010: pierlorenzo pallante; Rosa Visone; Carlo Maria Croce; Alfredo Fusco
Deregulation of microRNA expression in follicular-cell-derived human thyroid carcinomas.
Endocrine-related cancer 2010;17(1):F91-104.
2010: E Borbone; M T Berlingieri; F De Bellis; A Nebbioso; Gennaro Chiappetta; A Mai; L Altucci; Alfredo Fusco
Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation.
Oncogene 2010;29(1):105-16.
2010: Monica Fedele; Alfredo Fusco
HMGA and cancer.
Biochimica et biophysica acta 2010;1799(1-2):48-54.
2010: Gennaro Chiappetta; Alessandro Ottaiano; Emilia Vuttariello; Mario Monaco; Francesca Galdiero; Adolfo Gallipoli; Silvana Pilotti; Giovanna Jodice; Manoukian Siranoush; Mara Colombo; Carla B Ripamonti; pierlorenzo pallante; Paolo Radice; Alfredo Fusco
HMGA1 protein expression in familial breast carcinoma patients.
European journal of cancer (Oxford, England : 1990) 2010;46(2):332-9.
2009: Antonella Federico; pierlorenzo pallante; Mimma Bianco; Angelo Ferraro; Francesco Esposito; Maria Monti; Marianna Cozzolino; Simona Keller; Monica Fedele; Vincenza Leone; Giancarlo Troncone; Lorenzo Chiariotti; Piero Pucci; Alfredo Fusco
Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein.
Cancer research 2009;69(17):7079-87.
2009: Monica Fedele; Dario Palmieri; Gennaro Chiappetta; Rosa Pasquinelli; Ivana De Martino; Claudio Arra; Giuseppe Palma; Teresa Valentino; Giovanna Maria Pierantoni; Giuseppe Viglietto; Jay L Rothstein; Massimo Santoro; Alfredo Fusco
Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice.
Endocrine-related cancer 2009;16(2):483-90.
2009: Giancarlo Troncone; Eliana Guerriero; pierlorenzo pallante; Pierloronzo Pallante; Maria Teresa Berlingieri; Angelo Ferraro; Luigi Del Vecchio; Marisa Gorrese; Elisabetta Mariotti; Antonino Iaccarino; Emiliano A Palmieri; Pio Zeppa; Lucio Palombini; Alfredo Fusco
UbcH10 expression in human lymphomas.
Histopathology 2009;54(6):731-40.
2009: Ivana De Martino; Rosa Visone; Monica Fedele; Fabio Petrocca; Dario Palmieri; J Martinez Hoyos; Floriana Forzati; Carlo M Croce; Alfredo Fusco
Regulation of microRNA expression by HMGA1 proteins.
Oncogene 2009;28(11):1432-42.
2009: Maria Domenica Castellone; Valentina De Falco; Deva Magendra Rao; Roberto Bellelli; Magesh Muthu; Fulvio Basolo; Alfredo Fusco; J Silvio Gutkind; Massimo Santoro
The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.
Cancer research 2009;69(5):1867-76.
2009: Ivana De Martino; Rosa Visone; Anne Wierinckx; Dario Palmieri; Angelo Ferraro; Paolo Cappabianca; Gennaro Chiappetta; Floriana Forzati; Gaetano Lombardi; Annamaria Colao; Jacqueline Trouillas; Monica Fedele; Alfredo Fusco
HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas.
Cancer research 2009;69(5):1844-50.
2009: Rodolfo Iuliano; Cinzia Raso; Alfina Quintiero; Ilaria Le Pera; Flavia Pichiorri; Tiziana Palumbo; Dario Palmieri; Alessandra Pattarozzi; Tullio Florio; Giuseppe Viglietto; Francesco Trapasso; Carlo Maria Croce; Alfredo Fusco
The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization.
Journal of biochemistry 2009;145(3):377-85.
2009: Josefina Martinez Hoyos; Angelo Ferraro; S Sacchetti; S Keller; Ivana De Martino; Eleonora Borbone; pierlorenzo pallante; Monica Fedele; D Montanaro; Felice Esposito; Peter Cserjesi; Lorenzo Chiariotti; Giancarlo Troncone; Alfredo Fusco
HAND1 gene expression is negatively regulated by the High Mobility Group A1 proteins and is drastically reduced in human thyroid carcinomas.
Oncogene 2009;28(6):876-85.
2009: Eusebio Chiefari; Francesco Paonessa; Stefania Iiritano; Ilaria Le Pera; Dario Palmieri; Giuseppe Brunetti; Angelo Lupo; Vittorio Colantuoni; Daniela Foti; Elio Gulletta; Giovambattista De Sarro; Alfredo Fusco; Antonio Brunetti
The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis.
BMC biology 2009;7():24.
2008: Francesca Pentimalli; Dario Palmieri; Roberto Pacelli; Corrado Garbi; Rossano Cesari; Eric Martin; Giovanna Maria Pierantoni; Paolo Chieffi; Carlo Maria Croce; Vincenzo Costanzo; Monica Fedele; Alfredo Fusco
HMGA1 protein is a novel target of the ATM kinase.
European journal of cancer (Oxford, England : 1990) 2008;44(17):2668-79.
2008: pierlorenzo pallante; Antonella Federico; Maria Teresa Berlingieri; Mimma Bianco; Angelo Ferraro; Floriana Forzati; Antonino Iaccarino; Maria Russo; Giovanna Maria Pierantoni; Vincenza Leone; Silvana Sacchetti; Giancarlo Troncone; Massimo Santoro; Alfredo Fusco
Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer.
Cancer research 2008;68(16):6770-8.
2008: Gennaro Chiappetta; Angelo Ferraro; Emilia Vuttariello; Mario Monaco; Francesca Galdiero; Veronica De Simone; Daniela Califano; pierlorenzo pallante; Gerardo Botti; Luciano Pezzullo; Giovanna Maria Pierantoni; Massimo Santoro; Alfredo Fusco
HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias.
European journal of cancer (Oxford, England : 1990) 2008;44(7):1015-21.
2008: V Costa; Daniela Foti; Francesco Paonessa; Eusebio Chiefari; L Palaia; G Brunetti; Elio Gulletta; Alfredo Fusco; Antonio Brunetti
The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-gamma (PPARgamma) and thiazolidinedione-PPARgamma agonists.
Endocrine-related cancer 2008;15(1):325-35.
2008: Rosa Visone; Rodolfo Iuliano; Dario Palmieri; Ilter Nurettin Server; Gennaro Chiappetta; Ivana De Martino; Monica Fedele; Stefan Costinean; Tatiana M Oberyszyn; Donna F Kusewitt; Carlo M Croce; Alfredo Fusco
Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis.
European journal of cancer (Oxford, England : 1990) 2008;44(2):318-25.
2007: Alfredo Fusco; Monica Fedele
Roles of HMGA proteins in cancer.
Nature reviews. Cancer 2007;7(12):899-910.
2007: Maria Teresa Berlingieri; pierlorenzo pallante; Andrea Sboner; Mattia Barbareschi; Mimma Bianco; Angelo Ferraro; Gelsomina Mansueto; Eleonora Borbone; Eliana Guerriero; Giancarlo Troncone; Alfredo Fusco
UbcH10 is overexpressed in malignant breast carcinomas.
European journal of cancer (Oxford, England : 1990) 2007;43(18):2729-35.
2007: Rosa Visone; pierlorenzo pallante; Aldo Vecchione; R Cirombella; Manuela Ferracin; Angelo Ferraro; Stefano Volinia; S Coluzzi; Vincenza Leone; Eleonora Borbone; Chang-gong liu; Fabio Petrocca; Giancarlo Troncone; George A Calin; Aldo Scarpa; C Colato; Giovanni Tallini; Massimo Santoro; Carlo M Croce; Alfredo Fusco
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
Oncogene 2007;26(54):7590-5.
2007: Maria Letizia Motti; Carmela De Marco; Daniela Califano; Silvia De Gisi; Donatella Malanga; Giancarlo Troncone; Angela Persico; Simona Losito; Fernanda Fabiani; Massimo Santoro; Gennaro Chiappetta; Alfredo Fusco; Giuseppe Viglietto
Loss of p27 expression through RAS-->BRAF-->MAP kinase-dependent pathway in human thyroid carcinomas.
Cell cycle (Georgetown, Tex.) 2007;6(22):2817-25.
2007: Giuliana Salvatore; Tito Claudio Nappi; Paolo Salerno; Yuan Jiang; Corrado Garbi; Clara Ugolini; Paolo Miccoli; Fulvio Basolo; Maria Domenica Castellone; Anna Maria Cirafici; Rosa Marina Melillo; Alfredo Fusco; Michael Bittner; Massimo Santoro
A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.
Cancer research 2007;67(21):10148-58.
2007: Silvana Libertini; Irma Iacuzzo; Angelo Ferraro; Mario Vitale; Maurizio Bifulco; Alfredo Fusco; Giuseppe Portella
Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells.
Endocrinology 2007;148(11):5186-94.
2007: Giovanna Maria Pierantoni; Francesco Esposito; Stéphane Giraud; Willy V Bienvenut; Jean-Jacques Diaz; Alfredo Fusco
Identification of new high mobility group A1 associated proteins.
Proteomics 2007;7(20):3735-42.
2007: Francesco Merolla; Francesca Pentimalli; Roberto Pacelli; Giancarlo Vecchio; Alfredo Fusco; Michele Grieco; Angela Celetti
Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage.
Oncogene 2007;26(42):6167-75.
2007: Ivana De Martino; Rosa Visone; Dario Palmieri; Paolo Cappabianca; Paolo Chieffi; Floriana Forzati; Antonio Barbieri; Mogens Kruhoffer; Gaetano Lombardi; Alfredo Fusco; Monica Fedele
The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.
Endocrine-related cancer 2007;14(3):875-86.
2007: Rosa Visone; Lucia Russo; pierlorenzo pallante; Ivana De Martino; Angelo Ferraro; Vincenza Leone; Eleonora Borbone; Fabio Petrocca; Hansjuerg Alder; Carlo Maria Croce; Alfredo Fusco
MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle.
Endocrine-related cancer 2007;14(3):791-8.
2007: Massimo Santoro; Alfredo Fusco
New drugs in thyroid cancer.
Arquivos brasileiros de endocrinologia e metabologia 2007;51(5):857-61.
2007: Alfredo Fusco; Massimo Santoro
20 years of RET/PTC in thyroid cancer: clinico-pathological correlations.
Arquivos brasileiros de endocrinologia e metabologia 2007;51(5):731-5.
2007: Concetta Cuozzo; Antonio Porcellini; Tiziana Angrisano; Annalisa Morano; Bongyong Lee; Alba Di Pardo; samantha messina; Rodolfo Iuliano; Alfredo Fusco; Maria R Santillo; Mark T Muller; Lorenzo Chiariotti; Max E Gottesman; enrico vittorio avvedimento
DNA damage, homology-directed repair, and DNA methylation.
PLoS genetics 2007;3(7):e110.
2007: Gennaro Chiappetta; Carmela De Marco; Alfina Quintiero; Daniela Califano; Simona Gherardi; Donatella Malanga; Marianna Scrima; Cristina Montero-Conde; Letizia Cito; Mario Monaco; Maria Letizia Motti; Rosa Pasquinelli; Valter Agosti; Mercedes Robledo; Alfredo Fusco; Giuseppe Viglietto
Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer.
Endocrine-related cancer 2007;14(2):405-20.
2007: Roberta Visconti; Antonella Federico; Valeria Coppola; Francesca Pentimalli; Maria Teresa Berlingieri; pierlorenzo pallante; Mogens Kruhoffer; Torben F Orntoft; Alfredo Fusco
Transcriptional profile of Ki-Ras-induced transformation of thyroid cells.
Cancer investigation 2007;25(4):256-66.
2007: Monica Fedele; Ivana De Martino; Rosario Pivonello; Andrea Ciarmiello; M Laura Del Basso De Caro; Rosa Visone; Dario Palmieri; Giovanna Maria Pierantoni; Claudio Arra; Herbert A Schmid; Leo Hofland; Gaetano Lombardi; Annamaria Colao; Alfredo Fusco
SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin-secreting pituitary adenomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2738-44.
2007: Laura Casalino; Latifa Bakiri; Francesco Talotta; Jonathan B Weitzman; Alfredo Fusco; Moshe Yaniv; Pasquale Verde
Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription.
The EMBO journal 2007;26(7):1878-90.
2007: Maria Teresa Berlingieri; pierlorenzo pallante; M Guida; C Nappi; Valeria Masciullo; Giovanni Scambia; Angelo Ferraro; Vincenza Leone; Andrea Sboner; Mattia Barbareschi; A Ferro; Giancarlo Troncone; Alfredo Fusco
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas.
Oncogene 2007;26(14):2136-40.
2007: Giovanna Maria Pierantoni; Cinzia Rinaldo; Marcella Mottolese; Anna Di Benedetto; Francesco Esposito; Silvia Soddu; Alfredo Fusco
High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.
The Journal of clinical investigation 2007;117(3):693-702.
2007: Ivana De Martino; Monica Fedele; Dario Palmieri; Rosa Visone; Paolo Cappabianca; Anne Wierinckx; Jacqueline Trouillas; Alfredo Fusco
B-RAF mutations are a rare event in pituitary adenomas.
Journal of endocrinological investigation 2007;30(1):RC1-3.
2007: Gennaro Chiappetta; Angelo Ferraro; Gerardo Botti; Mario Monaco; Rosa Pasquinelli; Emilia Vuttariello; Liliane Arnaldi; Maurizio Di Bonito; Giuseppe D'Aiuto; Giovanna Maria Pierantoni; Alfredo Fusco
FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders.
BMC cancer 2007;7():17.
2007: Valentina De Falco; Maria Domenica Castellone; Gabriella De Vita; Anna Maria Cirafici; Jerome M Hershman; Carmen Guerrero; Alfredo Fusco; Rosa Marina Melillo; Massimo Santoro
RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.
Cancer research 2007;67(1):381-90.
2006: Massimo Santoro; Rosa Marina Melillo; Alfredo Fusco
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(5):645-53.
2006: Monica Fedele; Giovanna Maria Pierantoni; Rosa Visone; Alfredo Fusco
Critical role of the HMGA2 gene in pituitary adenomas.
Cell cycle (Georgetown, Tex.) 2006;5(18):2045-8.
2006: Giovanna Maria Pierantoni; Cinzia Rinaldo; Franca Esposito; M Mottolese; Silvia Soddu; Alfredo Fusco
High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity.
Cell death and differentiation 2006;13(9):1554-63.
2006: Donata Vitagliano; Giuseppe Portella; Giancarlo Troncone; A Francione; C Rossi; A Bruno; A Giorgini; S Coluzzi; Tito Claudio Nappi; Jay L Rothstein; Rosa Pasquinelli; Gennaro Chiappetta; Daniela Terracciano; Vincenzo Macchia; Rosa Marina Melillo; Alfredo Fusco; Massimo Santoro
Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.
Oncogene 2006;25(39):5467-74.
2006: Francesco Trapasso; Alessandra Drusco; Stefan Costinean; Hansjuerg Alder; Rami I Aqeilan; Rodolfo Iuliano; Eugenio Gaudio; Cinzia Raso; nicola zanesi; Carlo M Croce; Alfredo Fusco
Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis.
DNA and cell biology 2006;25(6):376-82.
2006: Monica Fedele; Rosa Visone; Ivana De Martino; Giancarlo Troncone; Dario Palmieri; Sabrina Battista; Andrea Ciarmiello; pierlorenzo pallante; Claudio Arra; Rosa Marina Melillo; Kristian Helin; Carlo Maria Croce; Alfredo Fusco
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.
Cancer cell 2006;9(6):459-71.
2006: pierlorenzo pallante; Rosa Visone; Manuela Ferracin; Angelo Ferraro; Maria Teresa Berlingieri; Giancarlo Troncone; Gennaro Chiappetta; Chang-gong liu; Massimo Santoro; Massimo Negrini; Carlo M Croce; Alfredo Fusco
MicroRNA deregulation in human thyroid papillary carcinomas.
Endocrine-related cancer 2006;13(2):497-508.
2006: Francesco Paonessa; Daniela Foti; Vanessa Costa; Eusebio Chiefari; Giuseppe Brunetti; Francesco Leone; Francesco Luciano; Frank Wu; Amy S Lee; Elio Gulletta; Alfredo Fusco; Antonio Brunetti
Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer.
Cancer research 2006;66(10):5085-93.
2006: Monica Fedele; Vincenzo Fidanza; Sabrina Battista; Francesca Pentimalli; Andres J P Klein-Szanto; Rosa Visone; Ivana De Martino; Antonio Curcio; Carmine Morisco; Luigi Del Vecchio; Gustavo Baldassarre; Claudio Arra; Giuseppe Viglietto; Ciro Indolfi; Carlo M Croce; Alfredo Fusco
Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.
Cancer research 2006;66(5):2536-43.
2006: Monica Fedele; Giovanna Maria Pierantoni; Rosa Visone; Alfredo Fusco
E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression.
Cell division 2006;1():17.
2006: Tiziana Angrisano; Francesca Lembo; Raffaela Pero; Francesco Natale; Alfredo Fusco; enrico vittorio avvedimento; Carmelo B Bruni; Lorenzo Chiariotti
TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters.
Nucleic acids research 2006;34(1):364-72.
2005: Giovanna Maria Pierantoni; Palma Finelli; Emanuele Valtorta; Daniela Giardino; Ornella Rodeschini; Francesco Esposito; Marco Losa; Alfredo Fusco; Lidia Larizza
High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy.
Endocrine-related cancer 2005;12(4):867-74.
2005: Gustavo Baldassarre; Barbara Belletti; Sabrina Battista; Milena S Nicoloso; Francesca Pentimalli; Monica Fedele; Carlo M Croce; Alfredo Fusco
HMGA1 protein expression sensitizes cells to cisplatin-induced cell death.
Oncogene 2005;24(45):6809-19.
2005: pierlorenzo pallante; Maria Teresa Berlingieri; Giancarlo Troncone; Mogens Kruhoffer; Torben F Orntoft; Giuseppe Viglietto; Alessia Caleo; Ilenia Migliaccio; M Decaussin-Petrucci; Massimo Santoro; Lucio Palombini; Alfredo Fusco
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
British journal of cancer 2005;93(4):464-71.
2005: Teresa Guida; Giuliana Salvatore; Pinuccia Faviana; Riccardo Giannini; Ginesa Garcia-Rostan; Livia Provitera; Fulvio Basolo; Alfredo Fusco; Francesca Carlomagno; Massimo Santoro
Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2005;90(8):4703-9.
2005: Daniela Foti; Eusebio Chiefari; Monica Fedele; Rodolfo Iuliano; Leonardo Brunetti; Francesco Paonessa; Guidalberto Manfioletti; Fabrizio Barbetti; Antonio Brunetti; Carlo M Croce; Alfredo Fusco; Antonio Brunetti
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.
Nature medicine 2005;11(7):765-73.
2005: Sabrina Battista; Monica Fedele; Josefina Martinez Hoyos; Francesca Pentimalli; Giovanna Maria Pierantoni; Rosa Visone; Ivana De Martino; Carlo Maria Croce; Alfredo Fusco
High-mobility-group A1 (HMGA1) proteins down-regulate the expression of the recombination activating gene 2 (RAG2).
The Biochemical journal 2005;389(Pt 1):91-7.
2005: Maria Letizia Motti; Daniela Califano; Gustavo Baldassarre; Angela Celetti; Francesco Merolla; Floriana Forzati; Maria Napolitano; Barbara Tavernise; Alfredo Fusco; Giuseppe Viglietto
Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas.
Carcinogenesis 2005;26(6):1021-34.
2005: Monica Fedele; Francesca Pentimalli; Gustavo Baldassarre; Sabrina Battista; Andres J P Klein-Szanto; Lawrence Kenyon; Rosa Visone; Ivana De Martino; Andrea Ciarmiello; Claudio Arra; Giuseppe Viglietto; Carlo M Croce; Alfredo Fusco
Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.
Oncogene 2005;24(21):3427-35.
2005: Rosa Marina Melillo; Maria Domenica Castellone; Valentina Guarino; Valentina De Falco; Anna Maria Cirafici; Giuliana Salvatore; Fiorina Caiazzo; Fulvio Basolo; Riccardo Giannini; Mogens Kruhoffer; Torben F Orntoft; Alfredo Fusco; Massimo Santoro
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
The Journal of clinical investigation 2005;115(4):1068-81.
2005: Dolores Di Vizio; Letizia Cito; Angelo Boccia; Paolo Chieffi; Luigi Insabato; Guido Pettinato; Maria Letizia Motti; Filippo Schepis; Wanda D'Amico; Fernanda Fabiani; Barbara Tavernise; Salvatore Venuta; Alfredo Fusco; Giuseppe Viglietto
Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.
Oncogene 2005;24(11):1882-94.
2005: Giuliana Salvatore; Gennaro Chiappetta; Yuri E Nikiforov; Myriam Decaussin-Petrucci; Alfredo Fusco; J Aidan Carney; Massimo Santoro
Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations.
European journal of cancer (Oxford, England : 1990) 2005;41(5):816-21.
2005: Maria Letizia Motti; Daniela Califano; Giancarlo Troncone; Carmela De Marco; Ilenia Migliaccio; Emiliano A Palmieri; Luciano Pezzullo; Lucio Palombini; Alfredo Fusco; Giuseppe Viglietto
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization.
The American journal of pathology 2005;166(3):737-49.
2005: Rosanna Sorrentino; Silvana Libertini; pierlorenzo pallante; Giancarlo Troncone; Lucio Palombini; Vassilios Bavetsias; Daniela Spalletti-Cernia; Paolo Laccetti; Spiros Linardopoulos; Paolo Chieffi; Alfredo Fusco; Giuseppe Portella
Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation.
The Journal of clinical endocrinology and metabolism 2005;90(2):928-35.
2005: Alfredo Fusco; Giuseppe Viglietto; Massimo Santoro
A new mechanism of BRAF activation in human thyroid papillary carcinomas.
The Journal of clinical investigation 2005;115(1):20-3.
2004: Massimo Santoro; Francesca Carlomagno; Rosa Marina Melillo; Alfredo Fusco
Dysfunction of the RET receptor in human cancer.
Cellular and molecular life sciences : CMLS 2004;61(23):2954-64.
2004: Massimo Santoro; Rosa Marina Melillo; Francesca Carlomagno; Giancarlo Vecchio; Alfredo Fusco
Minireview: RET: normal and abnormal functions.
Endocrinology 2004;145(12):5448-51.
2004: Gennaro Chiappetta; Gerardo Botti; Mario Monaco; Rosa Pasquinelli; Francesca Pentimalli; Maurizio Di Bonito; Giuseppe D'Aiuto; Monica Fedele; Rodolfo Iuliano; Emiliano A Palmieri; Giovanna Maria Pierantoni; Vincenzo Giancotti; Alfredo Fusco
HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7637-44.
2004: Rodolfo Iuliano; Ilaria Le Pera; Carmela Cristofaro; Francesco Baudi; Franco Arturi; pierlorenzo pallante; Maria Luisa Martelli; Francesco Trapasso; Lorenzo Chiariotti; Alfredo Fusco
The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis.
Oncogene 2004;23(52):8432-8.
2004: Francesco Trapasso; Sai Yendamuri; Kristoffel R Dumon; Rodolfo Iuliano; Rossano Cesari; Byron Feig; Robin Seto; Luisa Infante; Hideshi Ishii; Aldo Vecchione; Matthew J During; Carlo M Croce; Alfredo Fusco
Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo.
Carcinogenesis 2004;25(11):2107-14.
2004: Francesco Trapasso; Manuela Sarti; Rossano Cesari; Sai Yendamuri; Kristoffel R Dumon; Rami I Aqeilan; Francesca Pentimalli; Luisa Infante; Hansjuerg Alder; Nobutsugu Abe; Takashi Watanabe; Giuseppe Viglietto; Carlo M Croce; Alfredo Fusco
Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models.
Cancer gene therapy 2004;11(9):633-41.
2004: Josefina Martinez Hoyos; Monica Fedele; Sabrina Battista; Francesca Pentimalli; Mogens Kruhoffer; Claudio Arra; Torben F Orntoft; Carlo Maria Croce; Alfredo Fusco
Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation.
Cancer research 2004;64(16):5728-35.
2004: Francesca Carlomagno; Teresa Guida; Suresh Anaganti; Giancarlo Vecchio; Alfredo Fusco; Anderson Ryan; Marc Billaud; Massimo Santoro
Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors.
Oncogene 2004;23(36):6056-63.
2004: Maria Domenica Castellone; Valentina Guarino; Valentina De Falco; Francesca Carlomagno; Fulvio Basolo; Pinuccia Faviana; Mogens Kruhoffer; Torben F Orntoft; John P Russell; Jay L Rothstein; Alfredo Fusco; Massimo Santoro; Rosa Marina Melillo
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas.
Oncogene 2004;23(35):5958-67.
2004: Maria Letizia Motti; Carmela De Marco; Daniela Califano; Alfredo Fusco; Giuseppe Viglietto
Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer.
Cell cycle (Georgetown, Tex.) 2004;3(8):1074-80.
2004: Rosa Marina Melillo; Anna Maria Cirafici; Valentina De Falco; Marie Bellantoni; Gennaro Chiappetta; Alfredo Fusco; Francesca Carlomagno; Antonietta Picascia; Donatella Tramontano; Giovanni Tallini; Massimo Santoro
The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma.
The American journal of pathology 2004;165(2):511-21.
2004: Gennaro Chiappetta; Francesca Pentimalli; Mario Monaco; Monica Fedele; Rosa Pasquinelli; Giovanna Maria Pierantoni; Maria Teresa Ribecco; Giovanni Santelli; Daniela Califano; Luciano Pezzullo; Alfredo Fusco
Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias.
Oncology reports 2004;12(2):239-43.
2004: Donata Vitagliano; Francesca Carlomagno; Maria Letizia Motti; Giuseppe Viglietto; Yuri E Nikiforov; Marina N Nikiforova; Jerome M Hershman; Anderson Ryan; Alfredo Fusco; Rosa Marina Melillo; Massimo Santoro
Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.
Cancer research 2004;64(11):3823-9.
2004: Giuseppe Donato; Josefina Martinez Hoyos; Andrea Amorosi; Lorenza Maltese; Angelo Lavano; Giorgio Volpentesta; Francesco Signorelli; Francesca Pentimalli; pierlorenzo pallante; Giuseppe Ferraro; Luigi Tucci; Cosma Damiano Signorelli; Giuseppe Viglietto; Alfredo Fusco
High mobility group A1 expression correlates with the histological grade of human glial tumors.
Oncology reports 2004;11(6):1209-13.
2004: Maria Domenica Castellone; Angela Celetti; Valentina Guarino; Anna Maria Cirafici; Fulvio Basolo; Riccardo Giannini; Enzo Medico; Mogens Kruhoffer; Torben F Orntoft; Francesco Curcio; Alfredo Fusco; Rosa Marina Melillo; Massimo Santoro
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.
Oncogene 2004;23(12):2188-96.
2003: Giovanna Maria Pierantoni; Sabrina Battista; Francesca Pentimalli; Monica Fedele; Rosa Visone; Antonella Federico; Massimo Santoro; Giuseppe Viglietto; Alfredo Fusco
A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas.
Carcinogenesis 2003;24(12):1861-9.
2003: Francesca Pentimalli; Monica Dentice; Monica Fedele; Giovanna Maria Pierantoni; Letizia Cito; pierlorenzo pallante; Massimo Santoro; Giuseppe Viglietto; Paola Dal Cin; Alfredo Fusco
Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2.
Cancer research 2003;63(21):7423-7.
2003: Maria Letizia Motti; Angelo Boccia; Barbara Belletti; Paola Bruni; Giancarlo Troncone; Letizia Cito; Mario Monaco; Gennaro Chiappetta; Gustavo Baldassarre; Lucio Palombini; Alfredo Fusco; Giuseppe Viglietto
Critical role of cyclin D3 in TSH-dependent growth of thyrocytes and in hyperproliferative diseases of the thyroid gland.
Oncogene 2003;22(48):7576-86.
2003: Giuseppe Portella; Roberto Pacelli; Silvana Libertini; Laura Cella; Giancarlo Vecchio; Marco Salvatore; Alfredo Fusco
ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells.
The Journal of clinical endocrinology and metabolism 2003;88(10):5027-32.
2003: Raffaela Pero; Francesca Lembo; Paolo Chieffi; Giovanna Del Pozzo; Monica Fedele; Alfredo Fusco; Carmelo B Bruni; Lorenzo Chiariotti
Translational regulation of a novel testis-specific RNF4 transcript.
Molecular reproduction and development 2003;66(1):1-7.
2003: Giovanna Maria Pierantoni; Basilia Santulli; Irene Caliendo; Francesca Pentimalli; Gennaro Chiappetta; nicola zanesi; Massimo Santoro; Florencia Bulrich; Alfredo Fusco
HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia.
International journal of oncology 2003;23(2):363-7.
2003: Sabrina Battista; Francesca Pentimalli; Gustavo Baldassarre; Monica Fedele; Vincenzo Fidanza; Carlo M Croce; Alfredo Fusco
Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1496-8.
2003: Valeria Masciullo; Gustavo Baldassarre; Francesca Pentimalli; Maria Teresa Berlingieri; Angelo Boccia; Gennaro Chiappetta; Juan P Palazzo; Guidalberto Manfioletti; Vincenzo Giancotti; Giuseppe Viglietto; Giovanni Scambia; Alfredo Fusco
HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas.
Carcinogenesis 2003;24(7):1191-8.
2003: Giovanna Maria Pierantoni; Valter Agosti; Monica Fedele; Heather M Bond; Irene Caliendo; Gennaro Chiappetta; Francesco Lo Coco; Fabrizio Pane; Maria Caterina Turco; Giovanni Morrone; Salvatore Venuta; Alfredo Fusco
High-mobility group A1 proteins are overexpressed in human leukaemias.
The Biochemical journal 2003;372(Pt 1):145-50.
2003: Francesca Carlomagno; Donata Vitagliano; Teresa Guida; Fulvio Basolo; Maria Domenica Castellone; Rosa Marina Melillo; Alfredo Fusco; Massimo Santoro
Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).
The Journal of clinical endocrinology and metabolism 2003;88(4):1897-902.
2003: Gustavo Baldassarre; Sabrina Battista; Barbara Belletti; Sanjay Thakur; Francesca Pentimalli; Francesco Trapasso; Monica Fedele; Giovanna Maria Pierantoni; Carlo M Croce; Alfredo Fusco
Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma.
Molecular and cellular biology 2003;23(7):2225-38.
2003: Roberta Visconti; Filippo Schepis; Rodolfo Iuliano; Giovanna Maria Pierantoni; Li Zhang; Francesca Carlomagno; Caterina Battaglia; Maria Luisa Martelli; Francesco Trapasso; Massimo Santoro; Alfredo Fusco
Cloning and molecular characterization of a novel gene strongly induced by the adenovirus E1A gene in rat thyroid cells.
Oncogene 2003;22(7):1087-97.
2003: Rodolfo Iuliano; Francesco Trapasso; Ilaria Le Pera; Filippo Schepis; Irene Samà; Alessandra Clodomiro; Kristoffel R Dumon; Massimo Santoro; Lorenzo Chiariotti; Giuseppe Viglietto; Alfredo Fusco
An adenovirus carrying the rat protein tyrosine phosphatase eta suppresses the growth of human thyroid carcinoma cell lines in vitro and in vivo.
Cancer research 2003;63(4):882-6.
2003: Massimo Santoro; Rosa Marina Melillo; Francesca Carlomagno; Maria Domenica Castellone; Donata Vitagliano; Teresa Guida; Giancarlo Vecchio; Alfredo Fusco
Genetic alterations in differentiated thyroid cancer: what can be expected for gene expression profiling of thyroid carcinomas.
Annales d'endocrinologie 2003;64(1):62-3.
2003: Maria Domenica Castellone; Anna Maria Cirafici; Gabriella De Vita; Valentina De Falco; Luca Malorni; Giovanni Tallini; James A Fagin; Alfredo Fusco; Rosa Marina Melillo; Massimo Santoro
Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.
Oncogene 2003;22(2):246-55.
2003: Maren Meiboom; Hugo Murua Escobar; F Pentimalli; Alfredo Fusco; Gazanfer Belge; Jörn Bullerdiek
A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas.
Cytogenetic and genome research 2003;101(2):113-7.
2002: Francesca Carlomagno; Donata Vitagliano; Teresa Guida; Fortunato Ciardiello; Giampaolo Tortora; Giancarlo Vecchio; Anderson Ryan; Gabriella Fontanini; Alfredo Fusco; Massimo Santoro
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.
Cancer research 2002;62(24):7284-90.
2002: F de Nigris; J Cerutti; C Morelli; Daniela Califano; Lorenzo Chiariotti; Giuseppe Viglietto; Giovanni Santelli; Alfredo Fusco
Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.
British journal of cancer 2002;87(12):1479.
2002: Giuseppe Viglietto; Maria Letizia Motti; Alfredo Fusco
Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization.
Cell cycle (Georgetown, Tex.) 2002;1(6):394-400.
2002: Maria Luisa Martelli; Rodolfo Iuliano; Ilaria Le Pera; Irene Sama'; Carmen Monaco; Simona Cammarota; Todd Kroll; Lorenzo Chiariotti; Massimo Santoro; Alfredo Fusco
Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth.
The Journal of clinical endocrinology and metabolism 2002;87(10):4728-35.
2002: Giuseppe Viglietto; Maria Letizia Motti; Paola Bruni; Rosa Marina Melillo; Amelia D'Alessio; Daniela Califano; Floriana Vinci; Gennaro Chiappetta; Philip Tsichlis; Alfonso Bellacosa; Alfredo Fusco; Massimo Santoro
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
Nature medicine 2002;8(10):1136-44.
2002: Giovanni Santelli; Paola Cannada Bartoli; Ada Giuliano; Antonio Porcellini; Alba Mineo; Maria Vittoria Barone; Immacolata Busiello; Francesco Trapasso; Daniela Califano; Alfredo Fusco
Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium.
Thyroid : official journal of the American Thyroid Association 2002;12(9):765-72.
2002: Massimo Santoro; Rosa Marina Melillo; Francesca Carlomagno; Alfredo Fusco; Giancarlo Vecchio
Molecular mechanisms of RET activation in human cancer.
Annals of the New York Academy of Sciences 2002;963():116-21.
2002: Alfredo Fusco; Gennaro Chiappetta; Pei Hui; Ginesa Garcia-Rostan; Lauren Golden; Barbara K Kinder; Deborah A Dillon; Ada Giuliano; Anna Maria Cirafici; Massimo Santoro; Juan Rosai; Giovanni Tallini
Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer.
The American journal of pathology 2002;160(6):2157-67.
2002: Giuseppe Portella; Stefania Scala; Donata Vitagliano; Giancarlo Vecchio; Alfredo Fusco
ONYX-015, an E1B gene-defective adenovirus, induces cell death in human anaplastic thyroid carcinoma cell lines.
The Journal of clinical endocrinology and metabolism 2002;87(6):2525-31.
2002: Monica Fedele; Sabrina Battista; Lawrence Kenyon; Gustavo Baldassarre; Vincenzo Fidanza; Andres J P Klein-Szanto; A F Parlow; Rosa Visone; Giovanna Maria Pierantoni; Eric K Outwater; Massimo Santoro; Carlo M Croce; Alfredo Fusco
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.
Oncogene 2002;21(20):3190-8.
2002: Maria Teresa Berlingieri; Giovanna Maria Pierantoni; Vincenzo Giancotti; Massimo Santoro; Alfredo Fusco
Thyroid cell transformation requires the expression of the HMGA1 proteins.
Oncogene 2002;21(19):2971-80.
2002: Anna Curci; Immacolata Capasso; A Romano; Paola Bruni; Maria Letizia Motti; Sandro Pignata; Giuseppe D'Aiuto; Amelia Casamassimi; Michele D'Urso; Alfredo Fusco; Giuseppe Viglietto
Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples.
International journal of oncology 2002;20(5):963-70.
2002: Palma Finelli; Giovanna Maria Pierantoni; Daniela Giardino; Marco Losa; Ornella Rodeschini; Monica Fedele; Emanuele Valtorta; pietro mortini; Carlo M Croce; Lidia Larizza; Alfredo Fusco
The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas.
Cancer research 2002;62(8):2398-405.
2002: F de Nigris; J Cerutti; C Morelli; Daniela Califano; Lorenzo Chiariotti; Giuseppe Viglietto; Giovanni Santelli; Alfredo Fusco
Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.
British journal of cancer 2002;86(6):917-23.
2002: Gustavo Baldassarre; Paola Bruni; Angelo Boccia; Giuliana Salvatore; Rosa Marina Melillo; Maria Letizia Motti; Maria Napolitano; Barbara Belletti; Alfredo Fusco; Massimo Santoro; Giuseppe Viglietto
Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1).
Oncogene 2002;21(11):1739-49.
2002: Francesca Carlomagno; Donata Vitagliano; Teresa Guida; Maria Napolitano; Giancarlo Vecchio; Alfredo Fusco; Aviv Gazit; Alexander Levitzki; Massimo Santoro
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.
Cancer research 2002;62(4):1077-82.
2002: Fulvio Basolo; Riccardo Giannini; Antonio Toniolo; Rosario Casalone; Marina N Nikiforova; Furio Pacini; Rossella Elisei; Paolo Miccoli; Piero Berti; Pinuccia Faviana; Lisa Fiore; Carmen Monaco; Giovanna Maria Pierantoni; Monica Fedele; Yuri E Nikiforov; Massimo Santoro; Alfredo Fusco
Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement.
International journal of cancer. Journal international du cancer 2002;97(5):608-14.
2002: Raffaela Pero; Francesca Lembo; Emiliano A Palmieri; Carmen Vitiello; Monica Fedele; Alfredo Fusco; Carmelo B Bruni; Lorenzo Chiariotti
PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription.
The Journal of biological chemistry 2002;277(5):3280-5.
2002: Giovanna Maria Pierantoni; Alessandro Bulfone; Francesca Pentimalli; Monica Fedele; Rodolfo Iuliano; Massimo Santoro; Lorenzo Chiariotti; Andrea Ballabio; Alfredo Fusco
The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.
Biochemical and biophysical research communications 2002;290(3):942-7.
2002: Massimo Santoro; Mauro Papotti; Gennaro Chiappetta; Ginesa Garcia-Rostan; Marco Volante; Chaline Johnson; Robert L Camp; Francesca Pentimalli; Carmen Monaco; Agustin Herrero; Maria Luisa Carcangiu; Alfredo Fusco; Giovanni Tallini
RET activation and clinicopathologic features in poorly differentiated thyroid tumors.
The Journal of clinical endocrinology and metabolism 2002;87(1):370-9.
2002: Gennaro Chiappetta; Paolo Toti; Francesco Cetta; Ada Giuliano; Francesca Pentimalli; Ida Amendola; Stefano Lazzi; Mario Monaco; Luca Mazzuchelli; Piero Tosi; Massimo Santoro; Alfredo Fusco
The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions.
The Journal of clinical endocrinology and metabolism 2002;87(1):364-9.
2002: Fulvio Basolo; Riccardo Giannini; Carmen Monaco; Rosa Marina Melillo; Francesca Carlomagno; Martina Pancrazi; Giuliana Salvatore; Gennaro Chiappetta; Furio Pacini; Rossella Elisei; Paolo Miccoli; Aldo Pinchera; Alfredo Fusco; Massimo Santoro
Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma.
The American journal of pathology 2002;160(1):247-54.
2001: Fulvio Basolo; Eleonora Molinaro; Laura Agate; Aldo Pinchera; Luca Pollina; Gennaro Chiappetta; Carmen Monaco; Massimo Santoro; Alfredo Fusco; Paolo Miccoli; Rossella Elisei; Marco Capezzone; Furio Pacini
RET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(5):599-604.
2001: Maria Vittoria Barone; L Sepe; Rosa Marina Melillo; Alba Mineo; Giovanni Santelli; Carmen Monaco; Maria Domenica Castellone; Donatella Tramontano; Alfredo Fusco; Massimo Santoro
RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.
Oncogene 2001;20(48):6973-82.
2001: Serge Manié; Massimo Santoro; Alfredo Fusco; Marc Billaud
The RET receptor: function in development and dysfunction in congenital malformation.
Trends in genetics : TIG 2001;17(10):580-9.
2001: Raffaela Pero; Francesca Lembo; Dolores Di Vizio; Angelo Boccia; Paolo Chieffi; Monica Fedele; Giovanna Maria Pierantoni; P Rossi; Rodolfo Iuliano; Massimo Santoro; Giuseppe Viglietto; Carmelo B Bruni; Alfredo Fusco; Lorenzo Chiariotti
RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors.
The American journal of pathology 2001;159(4):1225-30.
2001: Monica Fedele; Sabrina Battista; Guidalberto Manfioletti; Carlo M Croce; Vincenzo Giancotti; Alfredo Fusco
Role of the high mobility group A proteins in human lipomas.
Carcinogenesis 2001;22(10):1583-91.
2001: Giovanna Maria Pierantoni; Monica Fedele; Francesca Pentimalli; G Benvenuto; Raffaela Pero; Giuseppe Viglietto; Massimo Santoro; Lorenzo Chiariotti; Alfredo Fusco
High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth.
Oncogene 2001;20(43):6132-41.
2001: Gustavo Baldassarre; Monica Fedele; Sabrina Battista; Aldo Vecchione; Andres J P Klein-Szanto; Massimo Santoro; Thomas Waldmann; N Azimi; Carlo M Croce; Alfredo Fusco
Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7970-5.
2001: Rosa Marina Melillo; Massimo Santoro; Sim-Heng Ong; Marc Billaud; Alfredo Fusco; YR Hadari; Joseph Schlessinger; Irit Lax
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.
Molecular and cellular biology 2001;21(13):4177-87.
2001: Rodolfo Iuliano; Francesco Trapasso; I Samà; Ilaria Le Pera; Maria Luisa Martelli; Francesca Lembo; Massimo Santoro; Giuseppe Viglietto; Lorenzo Chiariotti; Alfredo Fusco
Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of syntenin.
FEBS letters 2001;500(1-2):41-4.
2001: Monica Fedele; Giovanna Maria Pierantoni; Maria Teresa Berlingieri; Sabrina Battista; Gustavo Baldassarre; Nikhil C Munshi; Monica Dentice; Dimitris Thanos; Massimo Santoro; Giuseppe Viglietto; Alfredo Fusco
Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells.
Cancer research 2001;61(11):4583-90.
2001: Rosa Marina Melillo; Giovanna Maria Pierantoni; Stefania Scala; Sabrina Battista; Monica Fedele; A Stella; MC De Biasio; Gennaro Chiappetta; Vincenzo Fidanza; G Condorelli; Massimo Santoro; Carlo M Croce; Giuseppe Viglietto; Alfredo Fusco
Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation.
Molecular and cellular biology 2001;21(7):2485-95.
2001: Filomena de Nigris; T Mega; N Berger; Maria Vittoria Barone; Massimo Santoro; Giuseppe Viglietto; Pasquale Verde; Alfredo Fusco
Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation.
Cancer research 2001;61(5):2267-75.
2001: Domenico Salvatore; Rosa Marina Melillo; Carmen Monaco; Roberta Visconti; Gianfranco Fenzi; Giancarlo Vecchio; Alfredo Fusco; Massimo Santoro
Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B.
Cancer research 2001;61(4):1426-31.
2001: Carmen Monaco; Roberta Visconti; Maria Vittoria Barone; Giovanna Maria Pierantoni; Maria Teresa Berlingieri; Claudia De Lorenzo; Alba Mineo; Giancarlo Vecchio; Alfredo Fusco; Massimo Santoro
The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane.
Oncogene 2001;20(5):599-608.
2001: Stefania Scala; Giuseppe Portella; Donata Vitagliano; C Ledent; Gennaro Chiappetta; Vincenzo Giancotti; J Dumont; Alfredo Fusco
HMGI-C gene expression is not required for in vivo thyroid cell transformation.
Carcinogenesis 2001;22(2):251-6.
2001: Gennaro Chiappetta; Guidalberto Manfioletti; Francesca Pentimalli; N Abe; Maurizio Di Bonito; MT Vento; Ada Giuliano; Monica Fedele; Giuseppe Viglietto; Massimo Santoro; T Watanabe; Vincenzo Giancotti; Alfredo Fusco
High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases.
International journal of cancer. Journal international du cancer 2001;91(2):147-51.
2001: Rosa Marina Melillo; Francesca Carlomagno; Gabriella De Vita; Pietro Formisano; Giancarlo Vecchio; Alfredo Fusco; Marc Billaud; Massimo Santoro
The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.
Oncogene 2001;20(2):209-18.
2001: Giuseppe Portella; Cristina Borselli; Massimo Santoro; Diego Gerbasio; M R D'Armiento; J E Dumont; C Ledent; Jay L Rothstein; Giancarlo Vecchio; Alfredo Fusco
Human papilloma virus 16 E7 oncogene does not cooperate with RET/PTC 3 oncogene in the neoplastic transformation of thyroid cells in transgenic mice.
Oncology research 2001;12(8):347-54.
2000: Mauro Papotti; Marco Volante; Ada Giuliano; A Fassina; Alfredo Fusco; Gianni Bussolati; Massimo Santoro; Gennaro Chiappetta
RET/PTC activation in hyalinizing trabecular tumors of the thyroid.
The American journal of surgical pathology 2000;24(12):1615-21.
2000: Francesco Trapasso; Rodolfo Iuliano; Angelo Boccia; A Stella; Roberta Visconti; Paola Bruni; Gustavo Baldassarre; Massimo Santoro; Giuseppe Viglietto; Alfredo Fusco
Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1).
Molecular and cellular biology 2000;20(24):9236-46.
2000: John P Russell; Daniel J Powell; Mary F Cunnane; A Greco; Giuseppe Portella; Massimo Santoro; Alfredo Fusco; Jay L Rothstein
The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium.
Oncogene 2000;19(50):5729-35.
2000: Gennaro Chiappetta; Giovanni Tallini; MC De Biasio; Francesca Pentimalli; Filomena de Nigris; Simona Losito; Monica Fedele; Sabrina Battista; Pasquale Verde; Massimo Santoro; Alfredo Fusco
FRA-1 expression in hyperplastic and neoplastic thyroid diseases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(11):4300-6.
2000: Rodolfo Iuliano; Francesco Trapasso; A Stella; Ilaria Le Pera; R M Melillo; Paola Bruni; Gustavo Baldassarre; Lorenzo Chiariotti; Massimo Santoro; Giuseppe Viglietto; Alfredo Fusco
Pivotal role of the RB family proteins in in vitro thyroid cell transformation.
Experimental cell research 2000;260(2):257-67.
2000: Gustavo Baldassarre; Angelo Boccia; Paola Bruni; C Sandomenico; Maria Vittoria Barone; Stefano Pepe; T Angrisano; Barbara Belletti; Maria Letizia Motti; Alfredo Fusco; Giuseppe Viglietto
Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(10):517-26.
2000: Domenico Salvatore; Maria Vittoria Barone; Giuliana Salvatore; Rosa Marina Melillo; Gennaro Chiappetta; Alba Mineo; Gianfranco Fenzi; Giancarlo Vecchio; Alfredo Fusco; Massimo Santoro
Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins.
The Journal of clinical endocrinology and metabolism 2000;85(10):3898-907.
2000: Maria Luisa Martelli; Maria Giuseppina Miano; C Battaglia; Francesco Trapasso; A Stella; Rodolfo Iuliano; Roberta Visconti; James A Fagin; Massimo Santoro; Alfredo Fusco
The highly malignant phenotype of anaplastic thyroid carcinoma cell lines is recessive.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(4):515-21.
2000: Gabriella De Vita; Maria Teresa Berlingieri; Roberta Visconti; Maria Domenica Castellone; Giuseppe Viglietto; Gustavo Baldassarre; Mariastella Zannini; A Bellacosa; Philip Tsichlis; Alfredo Fusco; Massimo Santoro
Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects.
Cancer research 2000;60(14):3916-20.
2000: Gabriella De Vita; Rosa Marina Melillo; Francesca Carlomagno; Roberta Visconti; Maria Domenica Castellone; A Bellacosa; Marc Billaud; Alfredo Fusco; Philip Tsichlis; Massimo Santoro
Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.
Cancer research 2000;60(14):3727-31.
2000: Paola Bruni; Angelo Boccia; Gustavo Baldassarre; Francesco Trapasso; Massimo Santoro; Gennaro Chiappetta; Alfredo Fusco; Giuseppe Viglietto
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1.
Oncogene 2000;19(28):3146-55.
2000: B Santulli; B Kazmierczak; R Napolitano; Irene Caliendo; Gennaro Chiappetta; Volkhard Rippe; Jörn Bullerdiek; Alfredo Fusco
A 12q13 translocation involving the HMGI-C gene in richter transformation of a chronic lymphocytic leukemia.
Cancer genetics and cytogenetics 2000;119(1):70-3.
2000: Stefania Scala; Giuseppe Portella; Monica Fedele; Gennaro Chiappetta; Alfredo Fusco
Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4256-61.
2000: Giuseppe Viglietto; S Dolci; Paola Bruni; Gustavo Baldassarre; Lorenzo Chiariotti; Rosa Marina Melillo; Giuliana Salvatore; Gennaro Chiappetta; F Sferratore; Alfredo Fusco; Massimo Santoro
Glial cell line-derived neutrotrophic factor and neurturin can act as paracrine growth factors stimulating DNA synthesis of Ret-expressing spermatogonia.
International journal of oncology 2000;16(4):689-94.
2000: Monica Fedele; G Benvenuto; Raffaela Pero; Barbara Majello; Sabrina Battista; Francesca Lembo; E Vollono; P M Day; Massimo Santoro; Luigi Lania; Carmelo B Bruni; Alfredo Fusco; Lorenzo Chiariotti
A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor.
The Journal of biological chemistry 2000;275(11):7894-901.
2000: G Villone; G De Vita; Paolo Chieffi; Antonietta Picascia; Rosita Stanzione; Massimo Santoro; Alfredo Fusco; Donatella Tramontano
Association between the expression of E1A oncogene and increased sensitivity to growth inhibition induced by sustained levels of cAMP in rat thyroid cells.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(3):286-93.
2000: Riccardo Giannini; Giuliana Salvatore; Carmen Monaco; F Sferratore; Luca Pollina; Furio Pacini; Fulvio Basolo; Alfredo Fusco; Massimo Santoro
Identification of a novel subtype of H4-RET rearrangement in a thyroid papillary carcinoma and lymph node metastasis.
International journal of oncology 2000;16(3):485-9.
2000: Massimo Santoro; Gerry A Thomas; Giancarlo Vecchio; G H Williams; Alfredo Fusco; Gennaro Chiappetta; V Pozcharskaya; Tetyana I Bogdanova; EP Demidchik; ED Cherstvoy; L Voscoboinik; Nikolay Tronko; A Carss; H Bunnell; M Tonnachera; J Parma; J E Dumont; G Keller; H Höfler; E Dillwyn Williams
Gene rearrangement and Chernobyl related thyroid cancers.
British journal of cancer 2000;82(2):315-22.
1999: Gustavo Baldassarre; Maria Vittoria Barone; Barbara Belletti; C Sandomenico; Paola Bruni; S Spiezia; Angelo Boccia; MT Vento; A Romano; Stefano Pepe; Alfredo Fusco; Giuseppe Viglietto
Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation.
Oncogene 1999;18(46):6241-51.
1999: Massimo Santoro; Francesca Carlomagno; Rosa Marina Melillo; Marc Billaud; Giancarlo Vecchio; Alfredo Fusco
Molecular mechanisms of RET activation in human neoplasia.
Journal of endocrinological investigation 1999;22(10):811-9.
1999: Gerry A Thomas; H Bunnell; H A Cook; E Dillwyn Williams; A Nerovnya; ED Cherstvoy; Nikolay Tronko; Tetyana I Bogdanova; Gennaro Chiappetta; Giuseppe Viglietto; Francesca Pentimalli; Giuliana Salvatore; Alfredo Fusco; Massimo Santoro; Giancarlo Vecchio
High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant.
The Journal of clinical endocrinology and metabolism 1999;84(11):4232-8.
1999: Volkhard Rippe; Gazanfer Belge; Maren Meiboom; B Kazmierczak; Alfredo Fusco; Jörn Bullerdiek
A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors.
Genes, chromosomes & cancer 1999;26(3):229-36.
1999: Sabrina Battista; Vincenzo Fidanza; Monica Fedele; Andres J P Klein-Szanto; Eric K Outwater; H Brunner; Massimo Santoro; Carlo M Croce; Alfredo Fusco
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.
Cancer research 1999;59(19):4793-7.
1999: Gustavo Baldassarre; Barbara Belletti; Paola Bruni; Angelo Boccia; Francesco Trapasso; Francesca Pentimalli; Maria Vittoria Barone; Gennaro Chiappetta; MT Vento; S Spiezia; Alfredo Fusco; Giuseppe Viglietto
Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells.
The Journal of clinical investigation 1999;104(7):865-74.
1999: Giovanni Santelli; Daniela Califano; Gennaro Chiappetta; MT Vento; Paola Cannada Bartoli; F Zullo; Francesco Trapasso; Giuseppe Viglietto; Alfredo Fusco
Thymosin beta-10 gene overexpression is a general event in human carcinogenesis.
The American journal of pathology 1999;155(3):799-804.
1999: Barbara Belletti; P Ferraro; Claudio Arra; Gustavo Baldassarre; Paola Bruni; stefania staibano; G De Rosa; Giuliana Salvatore; Alfredo Fusco; M Graziella Persico; Giuseppe Viglietto
Modulation of in vivo growth of thyroid tumor-derived cell lines by sense and antisense vascular endothelial growth factor gene.
Oncogene 1999;18(34):4860-9.
1999: Fulvio Basolo; Lisa Fiore; Alfredo Fusco; Riccardo Giannini; Adriana Albini; GR Merlo; Gabriella Fontanini; Pier Giulio Conaldi; Antonio Toniolo
Potentiation of the malignant phenotype of the undifferentiated ARO thyroid cell line by insertion of the bcl-2 gene.
International journal of cancer. Journal international du cancer 1999;81(6):956-62.
1999: Giuseppe Viglietto; Daniela Califano; Paola Bruni; Gustavo Baldassarre; MT Vento; Barbara Belletti; Monica Fedele; Giovanni Santelli; Angelo Boccia; G Manzo; Massimo Santoro; Alfredo Fusco
Regulation of thymosin beta10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(6):597-607.
1999: Francesco Trapasso; Rodolfo Iuliano; Eusebio Chiefari; Franco Arturi; A Stella; Sebastiano Filetti; Alfredo Fusco; Diego Russo
Iodide symporter gene expression in normal and transformed rat thyroid cells.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(5):447-51.
1999: Massimo Santoro; Rosa Marina Melillo; Francesca Carlomagno; Roberta Visconti; Gabriella De Vita; Giuliana Salvatore; Alfredo Fusco; Giancarlo Vecchio
Different mutations of the RET gene cause different human tumoral diseases.
Biochimie 1999;81(4):397-402.
1999: Rosa Marina Melillo; Maria Vittoria Barone; Giovanni Lupoli; Anna Maria Cirafici; Francesca Carlomagno; Roberta Visconti; B Matoskova; P P Di Fiore; Giancarlo Vecchio; Alfredo Fusco; Massimo Santoro
Ret-mediated mitogenesis requires Src kinase activity.
Cancer research 1999;59(5):1120-6.
1999: Giuseppe Portella; Donata Vitagliano; Cristina Borselli; Rosa Marina Melillo; Domenico Salvatore; Jay L Rothstein; Giancarlo Vecchio; Alfredo Fusco; Massimo Santoro
Human N-ras, TRK-T1, and RET/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and the proliferation of thyroid epithelial cells.
Oncology research 1999;11(9):421-7.
1998: S Chappuis-Flament; A Pasini; Gabriella De Vita; C Ségouffin-Cariou; Alfredo Fusco; Tania Attié; Gilbert M Lenoir; Massimo Santoro; Marc Billaud
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.
Oncogene 1998;17(22):2851-61.
1998: Daniel J Powell; J Russell; Ken-ichi Nibu; G Li; E Rhee; M Liao; M Goldstein; William M Keane; Massimo Santoro; Alfredo Fusco; Jay L Rothstein
The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids.
Cancer research 1998;58(23):5523-8.
1998: B Kazmierczak; Paola Dal Cin; S Wanschura; Lars Borrmann; Alfredo Fusco; Herman Van Den Berghe; Jörn Bullerdiek
HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors.
Genes, chromosomes & cancer 1998;23(4):279-85.
1998: Maria Luisa Martelli; Francesco Trapasso; Paola Bruni; Maria Teresa Berlingieri; C Battaglia; MT Vento; Barbara Belletti; Rodolfo Iuliano; Massimo Santoro; Giuseppe Viglietto; Alfredo Fusco
Protein tyrosine phosphatase-eta expression is upregulated by the PKA-dependent and is downregulated by the PKC-dependent pathways in thyroid cells.
Experimental cell research 1998;245(1):195-202.
1998: F de Nigris; Roberta Visconti; J Cerutti; Daniela Califano; Alba Mineo; Massimo Santoro; Giovanni Santelli; Alfredo Fusco
Overexpression of the HIP gene coding for a heparin/heparan sulfate-binding protein in human thyroid carcinomas.
Cancer research 1998;58(20):4745-51.
1998: Stefania Scala; Paola Bruni; Lorenzo Lo Muzio; M Mignogna; Giuseppe Viglietto; Alfredo Fusco
Novel mutation of the PTEN gene in an Italian Cowden's disease kindred.
International journal of oncology 1998;13(4):665-8.
1998: Gennaro Chiappetta; Giovanni Tallini; MC De Biasio; Guidalberto Manfioletti; F J Martinez-Tello; Francesca Pentimalli; Filomena de Nigris; A Mastro; Gerardo Botti; Monica Fedele; N Berger; Massimo Santoro; Vincenzo Giancotti; Alfredo Fusco
Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma.
Cancer research 1998;58(18):4193-8.
1998: Francesca Carlomagno; Rosa Marina Melillo; Roberta Visconti; Giuliana Salvatore; Gabriella De Vita; Giovanni Lupoli; Yanbin Yu; Shuqian Jing; Giancarlo Vecchio; Alfredo Fusco; Massimo Santoro
Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease.
Endocrinology 1998;139(8):3613-9.
1998: Monica Fedele; Maria Teresa Berlingieri; Stefania Scala; Lorenzo Chiariotti; Giuseppe Viglietto; Volkhard Rippe; J Bullerdiek; Massimo Santoro; Alfredo Fusco
Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts.
Oncogene 1998;17(4):413-8.
1998: Sabrina Battista; Filomena de Nigris; Monica Fedele; Gennaro Chiappetta; Stefania Scala; D Vallone; Giovanna Maria Pierantoni; T Mega; Massimo Santoro; Giuseppe Viglietto; Pasquale Verde; Alfredo Fusco; T Megar
Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo.
Oncogene 1998;17(3):377-85.
1998: Amelia Casamassimi; Maria Giuseppina Miano; Antonio Porcellini; Gabriella De Vita; Filomena de Nigris; Mariastella Zannini; Roberto Di Lauro; Tommaso Russo; VE Avvedimento; Alfredo Fusco
p53 genes mutated in the DNA binding site or at a specific COOH-terminal site exert divergent effects on thyroid cell growth and differentiation.
Cancer research 1998;58(13):2888-94.
1998: Massimo Santoro; Rosa Marina Melillo; Francesca Carlomagno; Roberta Visconti; Gabriella De Vita; Giuliana Salvatore; Giovanni Lupoli; Alfredo Fusco; Giancarlo Vecchio
Molecular biology of the MEN2 gene.
Journal of internal medicine 1998;243(6):505-8.
1998: Mario Chiariello; Roberta Visconti; Francesca Carlomagno; Rosa Marina Melillo; C Bucci; Vittorio de Franciscis; GM Fox; Shuqian Jing; O A Coso; J Silvio Gutkind; Alfredo Fusco; Massimo Santoro
Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.
Oncogene 1998;16(19):2435-45.
1998: Daniela Califano; Carmen Monaco; Giovanni Santelli; Ada Giuliano; Maria L Veronese; Maria Teresa Berlingieri; Vittorio de Franciscis; N Berger; Francesco Trapasso; Massimo Santoro; Giuseppe Viglietto; Alfredo Fusco
Thymosin beta-10 gene overexpression correlated with the highly malignant neoplastic phenotype of transformed thyroid cells in vivo and in vitro.
Cancer research 1998;58(4):823-8.
1998: Lorenzo Chiariotti; G Benvenuto; Monica Fedele; Massimo Santoro; A Simeone; Alfredo Fusco; Carmelo B Bruni
Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3.
Genomics 1998;47(2):258-65.
1998: Giuseppe Portella; Donata Vitagliano; Z Li; F Sferratore; Massimo Santoro; Giancarlo Vecchio; Alfredo Fusco
TPA induces a block of differentiation and increases the susceptibility to neoplastic transformation of a rat thyroid epithelial cell line.
Oncology research 1998;10(9):441-7.
1998: Gabriella De Vita; Mariastella Zannini; Anna Maria Cirafici; Rosa Marina Melillo; Roberto Di Lauro; Alfredo Fusco; Massimo Santoro
Expression of the RET/PTC1 oncogene impairs the activity of TTF-1 and Pax-8 thyroid transcription factors.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(1):97-103.
1997: Lisa Fiore; Luca Pollina; Gabriella Fontanini; Rosario Casalone; M T Berlingieri; Riccardo Giannini; Furio Pacini; Paolo Miccoli; Antonio Toniolo; Alfredo Fusco; Fulvio Basolo
Cytokine production by a new undifferentiated human thyroid carcinoma cell line, FB-1.
The Journal of clinical endocrinology and metabolism 1997;82(12):4094-100.
1997: Giuseppe Viglietto; A Romano; G Manzo; Gennaro Chiappetta; I Paoletti; Daniela Califano; M G Galati; V Mauriello; Paola Bruni; Carmine T Lago; Alfredo Fusco; M Graziella Persico
Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization.
Oncogene 1997;15(22):2687-98.
1997: Roberta Visconti; J Cerutti; Sabrina Battista; Monica Fedele; Francesco Trapasso; K Zeki; M P Miano; F de Nigris; Laura Casalino; F Curcio; Massimo Santoro; Alfredo Fusco
Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.
Oncogene 1997;15(16):1987-94.
1997: Gazanfer Belge; E Garcia; Volkhard Rippe; Alfredo Fusco; S Bartnitzke; Jörn Bullerdiek
Breakpoints of 19q13 translocations of benign thyroid tumors map within a 400 kilobase region.
Genes, chromosomes & cancer 1997;20(2):201-3.
1997: D Vallone; Sabrina Battista; Giovanna Maria Pierantoni; Monica Fedele; Laura Casalino; Massimo Santoro; Giuseppe Viglietto; Alfredo Fusco; Pasquale Verde
Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product.
The EMBO journal 1997;16(17):5310-21.
1997: L Zhang; Maria Luisa Martelli; C Battaglia; Francesco Trapasso; Donatella Tramontano; Giuseppe Viglietto; Antonio Porcellini; Massimo Santoro; Alfredo Fusco
Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase.
Experimental cell research 1997;235(1):62-70.
1997: Anna Maria Cirafici; Giuliana Salvatore; Gabriella De Vita; Francesca Carlomagno; N A Dathan; Roberta Visconti; Rosa Marina Melillo; Alfredo Fusco; Massimo Santoro
Only the substitution of methionine 918 with a threonine and not with other residues activates RET transforming potential.
Endocrinology 1997;138(4):1450-5.
1997: Francesca Carlomagno; Giuliana Salvatore; Anna Maria Cirafici; Gabriella De Vita; Rosa Marina Melillo; Vittorio de Franciscis; Marc Billaud; Alfredo Fusco; Massimo Santoro
The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype.
Cancer research 1997;57(3):391-5.
1997: Ari Wirtschafter; R Schmidt; David Rosen; N Kundu; Massimo Santoro; Alfredo Fusco; H Multhaupt; Joseph P Atkins; Marc R Rosen; William M Keane; Jay L Rothstein
Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis.
The Laryngoscope 1997;107(1):95-100.