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Chiara Gabbiani

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Francesca Guidi; Ida Landini; Luca Bini; Angela Casini; Paul J Dyson; Chiara Gabbiani; Enrico Mini; Alessandra Modesti; Stefania Nobili; Michele Puglia; Luigi Messori
The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics.
Chiara Gabbiani; Lara Massai; Elena Michelucci; Federica Scaletti; Maria A Cinellu; Luigi Messori
Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications.
Chiara Gabbiani; Laura Maiore; Lara Massai; Elena Michelucci; Federica Scaletti; Maria A Cinellu; Luigi Messori
Protein metalation by metal-based drugs: reactions of cytotoxic gold compounds with cytochrome c and lysozyme.

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All Publications

2013: Francesca Guidi; Ida Landini; Luca Bini; Angela Casini; Paul J Dyson; Chiara Gabbiani; Enrico Mini; Alessandra Modesti; Stefania Nobili; Michele Puglia; Luigi Messori
The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics.
Journal of inorganic biochemistry 2013;118():94-9.
2012: Chiara Gabbiani; Lara Massai; Elena Michelucci; Federica Scaletti; Maria A Cinellu; Luigi Messori
Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications.
Chemical communications (Cambridge, England) 2012;48(95):11623-5.
2012: Chiara Gabbiani; Laura Maiore; Lara Massai; Elena Michelucci; Federica Scaletti; Maria A Cinellu; Luigi Messori
Protein metalation by metal-based drugs: reactions of cytotoxic gold compounds with cytochrome c and lysozyme.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2012;17(8):1293-302.
2012: Francesca Guidi; Ida Landini; Luca Bini; Maria A Cinellu; Dolores Fregona; Chiara Gabbiani; Tania Gamberi; Enrico Mini; Alessandra Modesti; Pietro Amedeo Modesti; Stefania Nobili; Michele Puglia; Luigi Messori
2D-DIGE analysis of ovarian cancer cell responses to cytotoxic gold compounds.
Molecular bioSystems 2012;8(4):985-93.
2012: Maria Serratrice; Antonio Zucca; Enrico Mini; Stefania Nobili; Maria Pilo; Maria A Cinellu; Chiara Gabbiani; Annalisa Guerri; Ida Landini; Laura Maiore; Luigi Messori
Synthesis, structural characterization, solution behavior, and in vitro antiproliferative properties of a series of gold complexes with 2-(2'-pyridyl)benzimidazole as ligand: comparisons of gold(III) versus gold(I) and mononuclear versus binuclear derivatives.
Inorganic chemistry 2012;51(5):3161-71.
2012: Francesca Guidi; Ida Landini; Francesca Magherini; Luigi Messori; Enrico Mini; Luca Bini; Maria A Cinellu; Tania Fiaschi; Chiara Gabbiani; Stefania Nobili; Michele Puglia; Alessandra Modesti
Proteomic analysis of ovarian cancer cell responses to cytotoxic gold compounds.
Metallomics : integrated biometal science 2012;4(3):307-14.
2012: Laura Maiore; Maria A Cinellu; Chiara Gabbiani; Ida Landini; Enrico Mini; Stefania Nobili; Luigi Messori
Gold(III) complexes with 2-substituted pyridines as experimental anticancer agents: solution behavior, reactions with model proteins, antiproliferative properties.
Journal of inorganic biochemistry 2012;108():123-7.
2012: Luigi Messori; Elena Michelucci; Carmen Navarro-Ranninger; José M Padrón; Giuseppe Pieraccini; Angela Casini; Leticia Cubo; Chiara Gabbiani; Leticia G León; Carla Ríos-Luci; Amparo Alvarez-Valdés; Adoracion Quiroga
Reactivity and biological properties of a series of cytotoxic PtI2(amine)2 complexes, either cis or trans configured.
Inorganic chemistry 2012;51(3):1717-26.
2011: Nicola Micale; Anna Rosa Sannella; Tanja Schirmeister; Carlo Severini; Maria A Cinellu; Chiara Gabbiani; Laura Maiore; Luigi Messori
Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro.
Journal of inorganic biochemistry 2011;105(12):1576-9.
2011: Chiara Gabbiani; Gerhard Kelter; Angela Casini; Maria A Cinellu; Fabio Cocco; Heinz-Herbert Fiebig; Luigi Messori
Mechanistic studies on two dinuclear organogold(III) compounds showing appreciable antiproliferative properties and a high redox stability.
Metallomics : integrated biometal science 2011;3(12):1318-23.
2011: Laura Maiore; Maria A Cinellu; Elena Michelucci; Gloriano Moneti; Stefania Nobili; Ida Landini; Enrico Mini; Annalisa Guerri; Chiara Gabbiani; Luigi Messori
Structural and solution chemistry, protein binding and antiproliferative profiles of gold(I)/(III) complexes bearing the saccharinato ligand.
Journal of inorganic biochemistry 2011;105(3):348-55.
2011: Luigi Messori; A Balerna; I Ascone; C Castellano; Chiara Gabbiani; Angela Casini; C Marchioni; G Jaouen; A Congiu Castellano
X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(3):491-9.
2011: Francesca Sorrentino; Anastasia Karioti; Paola Gratteri; Maria Pia Rigobello; Guido Scutari; Luigi Messori; Alberto Bindoli; Matteo Chioccioli; Chiara Gabbiani; Maria Camilla Bergonzi; Anna Rita Bilia
Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.
Bioorganic & medicinal chemistry 2011;19(1):631-41.
2010: Alessandro Pratesi; Chiara Gabbiani; Mauro Ginanneschi; Luigi Messori
Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis.
Chemical communications (Cambridge, England) 2010;46(37):7001-3.
2010: Chiara Gabbiani; Francesca Magherini; Alessandra Modesti; Luigi Messori
Proteomic and metallomic strategies for understanding the mode of action of anticancer metallodrugs.
Anti-cancer agents in medicinal chemistry 2010;10(4):324-37.
2010: Francesca Magherini; Alessandra Modesti; Luca Bini; Michele Puglia; Ida Landini; Stefania Nobili; Enrico Mini; Maria Agostina Cinellu; Chiara Gabbiani; Luigi Messori
Exploring the biochemical mechanisms of cytotoxic gold compounds: a proteomic study.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(4):573-82.
2010: Stefania Nobili; Enrico Mini; Ida Landini; Chiara Gabbiani; Angela Casini; Luigi Messori
Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies.
Medicinal research reviews 2010;30(3):550-80.
2010: Massimo Innocenti; Emanuele Salvietti; Martina Guidotti; Angela Casini; Silvano Bellandi; Maria Luisa Foresti; Chiara Gabbiani; Andrea Pozzi; Paolo Zatta; Luigi Messori
Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: an AFM study.
Journal of Alzheimer's disease : JAD 2010;19(4):1323-9.
2009: Chiara Gabbiani; Luigi Messori; Maria A Cinellu; Angela Casini; Pasquale Mura; Anna R Sannella; Carlo Severini; Giancarlo Majori; Anna R Bilia; Franco F Vincieri
Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials.
Journal of inorganic biochemistry 2009;103(2):310-2.
2009: Cristina Grossi; Simona Francese; Angela Casini; Maria Cristina Rosi; Ilaria Luccarini; Anna Fiorentini; Chiara Gabbiani; Luigi Messori; Gloriano Moneti; Fiorella Casamenti
Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2009;17(2):423-40.
2008: Angela Casini; Chiara Gabbiani; Francesca Sorrentino; Maria Pia Rigobello; Alberto Bindoli; Tilmann J Geldbach; Alessandro Marrone; Nazzareno Re; Christian G. Hartinger; Paul J Dyson; Luigi Messori
Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds.
Journal of medicinal chemistry 2008;51(21):6773-81.
2008: Chiara Gabbiani; Angela Casini; Guido Mastrobuoni; Noam Kirshenbaum; Ofra Moshel; Giuseppe Pieraccini; Gloriano Moneti; Luigi Messori; Dan Gibson
Peculiar mechanistic and structural features of the carboplatin-cytochrome c system revealed by ESI-MS analysis.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(5):755-64.
2008: Angela Casini; Annalisa Guerri; Chiara Gabbiani; Luigi Messori
Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: new insights from X-ray diffraction and mass spectrometry studies.
Journal of inorganic biochemistry 2008;102(5-6):995-1006.
2008: Angela Casini; Christian G. Hartinger; Chiara Gabbiani; Enrico Mini; Paul J Dyson; Bernard K Keppler; Luigi Messori
Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action.
Journal of inorganic biochemistry 2008;102(3):564-75.
2007: Pasquale Mura; Mercedes Camalli; Alberto Bindoli; Francesca Sorrentino; Angela Casini; Chiara Gabbiani; Maddalena Corsini; Piero Zanello; Maria Pia Rigobello; Luigi Messori
Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound.
Journal of medicinal chemistry 2007;50(24):5871-4.
2007: Alessandro Pratesi; Piero Zanello; Gianluca Giorgi; Luigi Messori; Franco Laschi; Angela Casini; Maddalena Corsini; Chiara Gabbiani; Marco Orfei; Claudia Rosani; Mauro Ginanneschi
New copper(II)/cyclic tetrapeptide system that easily oxidizes to copper(III) under atmospheric oxygen.
Inorganic chemistry 2007;46(24):10038-40.
2007: Angela Casini; Guido Mastrobuoni; Mattia Terenghi; Chiara Gabbiani; Enrico Monzani; Gloriano Moneti; Luigi Casella; Luigi Messori
Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome c.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(8):1107-17.
2007: Angela Casini; Chiara Gabbiani; Guido Mastrobuoni; Raffaella Zoe Pellicani; Francesco Paolo Intini; Fabio Arnesano; Giovanni Natile; Gloriano Moneti; Simona Francese; Luigi Messori
Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer platinum(II) iminoethers with horse heart cytochrome c.
Biochemistry 2007;46(43):12220-30.
2007: Luigi Messori; Angela Casini; Chiara Gabbiani; Lorenzo Sorace; Maurizio Muniz-Miranda; Paolo Zatta
Unravelling the chemical nature of copper cuprizone.
Dalton transactions (Cambridge, England : 2003) 2007;(21):2112-4.
2007: Angela Casini; Guido Mastrobuoni; Wee Han Ang; Chiara Gabbiani; Giuseppe Pieraccini; Gloriano Moneti; Paul J Dyson; Luigi Messori
ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes.
ChemMedChem 2007;2(5):631-5.
2007: Laura Ciani; Angela Casini; Chiara Gabbiani; Sandra Ristori; Luigi Messori; Giacomo Martini
DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques.
Biophysical chemistry 2007;127(3):213-20.
2007: Justyna Brasuń; Agnieszka Matera; Stanisław Ołdziej; Jolanta Swiatek-Kozłowska; Luigi Messori; Chiara Gabbiani; Marco Orfei; Mauro Ginanneschi
The copper(II) coordination abilities of three novel cyclic tetrapeptides with -His-Xaa-His- motif.
Journal of inorganic biochemistry 2007;101(3):452-60.
2007: Angela Casini; Guido Mastrobuoni; Claudia Temperini; Chiara Gabbiani; Simona Francese; Gloriano Moneti; Claudiu T Supuran; Andrea Scozzafava; Luigi Messori
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme.
Chemical communications (Cambridge, England) 2007;(2):156-8.
2006: Angela Casini; Maria Agostina Cinellu; Giovanni Minghetti; Chiara Gabbiani; Marcella Coronnello; Enrico Mini; Luigi Messori
Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligands.
Journal of medicinal chemistry 2006;49(18):5524-31.
2006: Luigi Messori; Chiara Gabbiani; Angela Casini; Matteo Siragusa; Franco Francesco Vincieri; Anna Rita Bilia
The reaction of artemisinins with hemoglobin: a unified picture.
Bioorganic & medicinal chemistry 2006;14(9):2972-7.
2006: Angela Casini; Chiara Gabbiani; Guido Mastrobuoni; Luigi Messori; Gloriano Moneti; Giuseppe Pieraccini
Exploring metallodrug-protein interactions by ESI mass spectrometry: the reaction of anticancer platinum drugs with horse heart cytochrome c.
ChemMedChem 2006;1(4):413-7.
2005: Marcella Coronnello; Enrico Mini; Barbara Caciagli; Maria Agostina Cinellu; Alberto Bindoli; Chiara Gabbiani; Luigi Messori
Mechanisms of cytotoxicity of selected organogold(III) compounds.
Journal of medicinal chemistry 2005;48(21):6761-5.
2005: Paolo Zatta; Luigi Messori; Pierluigi Mauri; Susan J van Rensburg; Johann van Zyl; Silvia Gabrielli; Chiara Gabbiani
The C2 variant of human serum transferrin retains the iron binding properties of the native protein.
Biochimica et biophysica acta 2005;1741(3):264-70.
2005: Rodorico Giorgi; Claudio Bozzi; Luigi Dei; Chiara Gabbiani; Barry W Ninham; Piero Baglioni
Nanoparticles of Mg(OH)2: synthesis and application to paper conservation.
Langmuir : the ACS journal of surfaces and colloids 2005;21(18):8495-501.
2005: Pasquale Mura; Francesca Piccioli; Chiara Gabbiani; Mercedes Camalli; Luigi Messori
Structure-function relationships within Keppler-type antitumor ruthenium(III) complexes: the case of 2-aminothiazolium[trans-tetrachlorobis(2-aminothiazole)ruthenate(III)].
Inorganic chemistry 2005;44(14):4897-9.
2004: Justyna Brasun; Chiara Gabbiani; Mauro Ginanneschi; Luigi Messori; Marco Orfei; Jolanta Swiatek-Kozlowska
The copper(II) binding properties of the cyclic peptide c(HGHK).
Journal of inorganic biochemistry 2004;98(12):2016-21.
2004: Luigi Messori; Giordana Marcon; Maria Agostina Cinellu; Marcella Coronnello; Enrico Mini; Chiara Gabbiani; Pierluigi Orioli
Solution chemistry and cytotoxic properties of novel organogold(III) compounds.
Bioorganic & medicinal chemistry 2004;12(23):6039-43.