FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Christian Gachet

Research Profile

Anatomy

Chemicals & Drugs

Physiology

Living Beings

Co-author Network

Publications

TOP 3
Philippe Ohlmann; Marco Cattaneo; Ali El-Tayeb; Anna Lecchi; Christa E Müller; Christian Gachet
The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.
Catherine Léon; Fabien Pertuy; Patricia Laeuffer; Frank Dombrowski; Anita Eckly; Katja Evert; Christian Gachet; Andreas Greinacher
Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD.
M Schaff; Philippe Ohlmann; N Receveur; C Bourdon; Christian Gachet; François Lanza; Pierre Mangin
β-arrestin-1 participates in thrombosis and regulates integrin aIIbβ3 signalling without affecting P2Y receptors desensitisation and function.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Christian Gachet (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Philippe Ohlmann; Marco Cattaneo; Ali El-Tayeb; Anna Lecchi; Christa E Müller; Christian Gachet
The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.
Purinergic signalling 2013;9(1):59-66.
2012: Catherine Léon; Fabien Pertuy; Patricia Laeuffer; Frank Dombrowski; Anita Eckly; Katja Evert; Christian Gachet; Andreas Greinacher
Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD.
Blood 2012;119(14):3333-41.
2012: M Schaff; Philippe Ohlmann; N Receveur; C Bourdon; Christian Gachet; François Lanza; Pierre Mangin
β-arrestin-1 participates in thrombosis and regulates integrin aIIbβ3 signalling without affecting P2Y receptors desensitisation and function.
Thrombosis and haemostasis 2012;107(4):735-48.
2012: Catherine Angénieux; Christian Gachet; Alexandre Gidon; Daniel Hanau; Rim Hojeij; Fabienne Proamer; Jean Salamero; François Signorino-Gelo; Alain Van Dorsselaer; François Waharte; Virginie Wurtz; Henri de la Salle
Lysosomal-associated transmembrane protein 5 (LAPTM5) is a molecular partner of CD1e.
PloS one 2012;7(8):e42634.
2012: Anita Eckly; François Lanza; Catherine Léon; Catherine Strassel; Jean-Pierre Cazenave; Christian Gachet
Characterization of megakaryocyte development in the native bone marrow environment.
Methods in molecular biology (Clifton, N.J.) 2012;788():175-92.
2012: Catherine Strassel; Catherine Léon; Sylvie Moog; Jean-Pierre Cazenave; Anita Eckly; Christian Gachet; François Lanza
Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors.
Experimental cell research 2012;318(1):25-32.
2011: Thomas Cuisset; Christian Gachet; Pierre-Emmanuel Morange; Jacques Quilici; Jean Louis Bonnet; Marie-Christine Alessi
Paraoxonase-1 and clopidogrel efficacy.
Nature medicine 2011;17(9):1039; author reply 1042-4.
2011: Béatrice Hechler; Christian Gachet
P2 receptors and platelet function.
Purinergic signalling 2011;7(3):293-303.
2011: Murielle Zerr; Béatrice Hechler; Monique Freund; Stéphanie Magnenat; Isabelle Lanois; Jean-Pierre Cazenave; Catherine Léon; Christian Gachet
Major contribution of the P2Y₁receptor in purinergic regulation of TNFα-induced vascular inflammation.
Circulation 2011;123(21):2404-13.
2011: Béatrice Hechler; Christian Gachet
Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury.
Thrombosis and haemostasis 2011;105 Suppl 1():S3-12.
2011: Duncan B Johnstone; Jidong Zhang; Britta George; Catherine Léon; Christian Gachet; Hetty Wong; Rulan S Parekh; Lawrence B Holzman
Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy.
Molecular and cellular biology 2011;31(10):2162-70.
2011: A Eckly; B Hechler; M Freund; M Zerr; Jean-Pierre Cazenave; François Lanza; P H Mangin; Christian Gachet
Mechanisms underlying FeCl3-induced arterial thrombosis.
Journal of thrombosis and haemostasis : JTH 2011;9(4):779-89.
2011: Olivier Morel; Soraya El Ghannudi; Laurence Jesel; Bogdan Radulescu; Nicolas Meyer; Marie-Louise Wiesel; Sophie Caillard; Umberto Campia; Bruno Moulin; Christian Gachet; Patrick Ohlmann
Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel.
Journal of the American College of Cardiology 2011;57(4):399-408.
2011: Mathieu Schaff; Nicolas Receveur; Catherine Bourdon; Virginie Wurtz; Cécile V Denis; Gertraud Orend; Christian Gachet; François Lanza; Pierre H Mangin
Novel function of tenascin-C, a matrix protein relevant to atherosclerosis, in platelet recruitment and activation under flow.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(1):117-24.
2010: B Maître; P H Mangin; A Eckly; V Heim; Jean-Pierre Cazenave; François Lanza; Daniel Hanau; Christian Gachet
Immature myeloid dendritic cells capture and remove activated platelets from preformed aggregates.
Journal of thrombosis and haemostasis : JTH 2010;8(10):2262-72.
2010: Philippe Ohlmann; Sonia de Castro; Garth G Brown; Christian Gachet; Kenneth Alan Jacobson; T Kendall Harden
Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500).
Pharmacological research : the official journal of the Italian Pharmacological Society 2010;62(4):344-51.
2010: Laurent Bonello; Udaya S Tantry; Rossella Marcucci; Ruediger Blindt; Dominick J Angiolillo; Richard Becker; Deepak L Bhatt; Marco Cattaneo; Jean Philippe Collet; Thomas Cuisset; Christian Gachet; Gilles Montalescot; Lisa K Jennings; Dean Kereiakes; Dirk Sibbing; Dietmar Trenk; Jochem W van Werkum; Franck Paganelli; Matthew J Price; Ron Waksman; Paul A Gurbel
Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate.
Journal of the American College of Cardiology 2010;56(12):919-33.
2010: Markus Bender; Anita Eckly; John H Hartwig; Margitta Elvers; Irina Pleines; Shuchi Gupta; Georg Krohne; Elisabeth Jeanclos; Antje Gohla; Christine Gurniak; Christian Gachet; Walter Witke; Bernhard Nieswandt
ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.
Blood 2010;116(10):1767-75.
2010: Catherine Ravanat; Catherine Strassel; Béatrice Hechler; Simone Schuhler; Gaëtan Chicanne; Bernard Payrastre; Christian Gachet; François Lanza
A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIbalpha N-terminal extracellular domain.
Blood 2010;116(7):1157-64.
2010: Sonia De Castro; Hiroshi Maruoka; Kunlun Hong; S Michael Kilbey; Stefano Costanzi; Béatrice Hechler; Garth G Brown; Christian Gachet; T Kendall Harden; Kenneth Alan Jacobson
Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.
Bioconjugate chemistry 2010;21(7):1190-205.
2010: Soraya El Ghannudi; Patrick Ohlmann; Nicolas Meyer; Marie-Louise Wiesel; Bogdan Radulescu; Michel Chauvin; Pierre Bareiss; Christian Gachet; Olivier Morel
Impact of P2Y12 inhibition by clopidogrel on cardiovascular mortality in unselected patients treated by percutaneous coronary angioplasty: a prospective registry.
JACC. Cardiovascular interventions 2010;3(6):648-56.
2010: Armin J Reininger; Isabell Bernlochner; Sandra M Penz; Catherine Ravanat; Peter Smethurst; Richard W Farndale; Christian Gachet; Richard Brandl; Wolfgang Siess
A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques.
Journal of the American College of Cardiology 2010;55(11):1147-58.
2009: Susanne Reiner; Nicole Ziegler; Catherine Leon; Kristina Lorenz; Kathrin von Hayn; Christian Gachet; Martin J Lohse; Carsten Hoffmann
beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites.
Molecular pharmacology 2009;76(6):1162-71.
2009: Yoonkyung Kim; Béatrice Hechler; Zhan-Guo Gao; Christian Gachet; Kenneth Alan Jacobson
PEGylated dendritic unimolecular micelles as versatile carriers for ligands of G protein-coupled receptors.
Bioconjugate chemistry 2009;20(10):1888-98.
2009: Sandra Eliautou; Pierre Henri Mangin; Ulrich Walter; Christian Gachet; François Lanza
Normal filopodia extension in VASP-deficient platelets upon activation by adhesive matrices or soluble agonists.
Thrombosis and haemostasis 2009;102(4):792-4.
2009: Ivette Grimm; Nanette Messemer; Matthias Stanke; Christian Gachet; Herbert Zimmermann
Coordinate pathways for nucleotide and EGF signaling in cultured adult neural progenitor cells.
Journal of cell science 2009;122(Pt 14):2524-33.
2009: Catherine Strassel; Anita Eckly; Catherine Léon; Claire Petitjean; Monique Freund; Jean-Pierre Cazenave; Christian Gachet; François Lanza
Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.
Haematologica 2009;94(6):800-10.
2009: Blandine Maître; Catherine Angénieux; Virginie Wurtz; Emilie Layre; Martine GILLERON; Anthony Collmann; Sabrina Mariotti; Lucia Mori; Dominique Fricker; Jean-Pierre Cazenave; Alain Van Dorsselaer; Christian Gachet; Gennaro De Libero; Germain Puzo; Daniel Hanau; Henri de la Salle
The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments.
The Biochemical journal 2009;419(3):661-8.
2009: Anita Eckly; Catherine Strassel; Monique Freund; Jean-Pierre Cazenave; François Lanza; Christian Gachet; Catherine Léon
Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.
Blood 2009;113(14):3182-9.
2009: Susan Smyth; Donna S Woulfe; Jeffrey I Weitz; Christian Gachet; Pamela B Conley; Shaun G Goodman; Matthew T Roe; Athan Kuliopulos; David J Moliterno; Patricia A French; Steven R Steinhubl; Richard C Becker
G-protein-coupled receptors as signaling targets for antiplatelet therapy.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):449-57.
2009: Catherine Ravanat; Virginie Wurtz; Philippe Ohlmann; Marie Fichter; Jean-Pierre Cazenave; Alain Vandorsselaer; François Lanza; Christian Gachet
Use of tandem Biacore-mass spectrometry to identify platelet membrane targets of novel monoclonal antibodies.
Analytical biochemistry 2009;386(2):237-43.
2009: Yoonkyung Kim; Athena M Klutz; Béatrice Hechler; Zhan-Guo Gao; Christian Gachet; Kenneth Alan Jacobson
Application of the functionalized congener approach to dendrimer-based signaling agents acting through A(2A) adenosine receptors.
Purinergic signalling 2009;5(1):39-50.
2008: Boris Aleil; Laurent Jacquemin; Fabien De Poli; Michel Zaehringer; Jean-Philippe Collet; Gilles Montalescot; Jean-Pierre Cazenave; Marie-Claude Dickele; Jean-Pierre Monassier; Christian Gachet
Clopidogrel 150 mg/day to overcome low responsiveness in patients undergoing elective percutaneous coronary intervention: results from the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) randomized study.
JACC. Cardiovascular interventions 2008;1(6):631-8.
2008: Boris Aleil; Laurence Kessler; Nicolas Meyer; Marie-Louise Wiesel; Julia Simeoni; Jean-Pierre Cazenave; Michel Pinget; Christian Gachet; François Lanza
Plasma levels of soluble platelet glycoprotein V are linked to fasting blood glucose in patients with type 2 diabetes.
Thrombosis and haemostasis 2008;100(4):713-5.
2008: Béatrice Hechler; Monique Freund; Catherine Ravanat; Stéphanie Magnenat; Jean-Pierre Cazenave; Christian Gachet
Reduced atherosclerotic lesions in P2Y1/apolipoprotein E double-knockout mice: the contribution of non-hematopoietic-derived P2Y1 receptors.
Circulation 2008;118(7):754-63.
2008: Amelia E Atterbury-Thomas; Catherine Leon; Christian Gachet; Ian D Forsythe; Richard J Evans
Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures.
Neuroscience letters 2008;435(3):190-3.
2008: Zhan-Guo Gao; Béatrice Hechler; Pedro Besada; Christian Gachet; Kenneth Alan Jacobson
Caged agonist of P2Y1 and P2Y12 receptors for light-directed facilitation of platelet aggregation.
Biochemical pharmacology 2008;75(6):1341-7.
2008: Christian Gachet
P2 receptors, platelet function and pharmacological implications.
Thrombosis and haemostasis 2008;99(3):466-72.
2008: Yoonkyung Kim; Béatrice Hechler; Athena M Klutz; Christian Gachet; Kenneth Alan Jacobson
Toward multivalent signaling across G protein-coupled receptors from poly(amidoamine) dendrimers.
Bioconjugate chemistry 2008;19(2):406-11.
2008: christelle nonne; Béatrice Hechler; Jean-Pierre Cazenave; Christian Gachet; François Lanza
Reassessment of in vivo thrombus formation in glycoprotein V deficient mice backcrossed on a C57Bl/6 strain.
Journal of thrombosis and haemostasis : JTH 2008;6(1):210-2.
2007: Nicolas Lantz; Béatrice Hechler; Catherine Ravanat; Jean-Pierre Cazenave; Christian Gachet
A high concentration of ADP induces weak platelet granule secretion independently of aggregation and thromboxane A2 production.
Thrombosis and haemostasis 2007;98(5):1145-7.
2007: Catherine Léon; Anita Eckly; Béatrice Hechler; Boris Aleil; Monique Freund; Catherine Ravanat; Marie Jourdain; christelle nonne; Josiane Weber; Ralph Tiedt; Marie-Pierre Gratacap; Sonia Severin; Jean-Pierre Cazenave; François Lanza; Radek C Skoda; Christian Gachet
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.
Blood 2007;110(9):3183-91.
2007: Simone M Schoenwaelder; Akiko Ono; Sharelle A Sturgeon; Siew Mei Chan; Pierre Mangin; Mhairi Maxwell; Shannon Turnbull; Megha Mulchandani; Karen Anderson; Gilles kauffenstein; Gordon W Rewcastle; Jackie Kendall; Christian Gachet; Hatem H Salem; Shaun P Jackson
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.
The Journal of biological chemistry 2007;282(39):28648-58.
2007: Virginie Wurtz; Béatrice Hechler; Philippe Ohlmann; Hervé Isola; Christine Schaeffer-Reiss; Jean-Pierre Cazenave; Alain Van Dorsselaer; Christian Gachet
Identification of platelet factor 4 and beta-thromboglobulin by profiling and liquid chromatography tandem mass spectrometry of supernatant peptides in stored apheresis and buffy-coat platelet concentrates.
Transfusion 2007;47(6):1099-101.
2007: Boris Aleil; G Rochoux; J-P Monassier; Jean-Pierre Cazenave; Christian Gachet
Ticlopidine could be an alternative therapy in the case of pharmacological resistance to clopidogrel: a report of three cases.
Journal of thrombosis and haemostasis : JTH 2007;5(4):879-81.
2007: Sonia Séverin; Marie-Pierre Gratacap; Nadège Lenain; Laetitia Alvarez; Etienne Hollande; Josef M Penninger; Christian Gachet; Monique Plantavid; Bernard Payrastre
Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth.
The Journal of clinical investigation 2007;117(4):944-52.
2007: Bernd Hohenstein; Sindy Renk; Kathrin Lang; Christoph Daniel; Monique Freund; Catherine Léon; Kerstin U Amann; Christian Gachet; Christian Hugo
P2Y1 gene deficiency protects from renal disease progression and capillary rarefaction during passive crescentic glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2007;18(2):494-505.
2007: Catherine Strassel; christelle nonne; Anita Eckly; Tovo David; C Leon; Monique Freund; Jean-Pierre Cazenave; Christian Gachet; François Lanza
Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(1):241-7.
2006: Tovo David; Philippe Ohlmann; Anita Eckly; Sylvie Moog; Jean-Pierre Cazenave; Christian Gachet; François Lanza
Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide.
Journal of thrombosis and haemostasis : JTH 2006;4(12):2645-55.
2006: Boris Aleil; Nicolas Meyer; Valérie Wolff; Daniel Kientz; Marie-Louise Wiesel; Christian Gachet; Jean-Pierre Cazenave; François Lanza
Plasma glycoprotein V levels in the general population: normal distribution, associated parameters and implications for clinical studies.
Thrombosis and haemostasis 2006;96(4):505-11.
2006: Jane F Arthur; Yang Shen; Fi-Tjen Mu; Catherine Leon; Christian Gachet; Michael C Berndt; Robert K Andrews
Calmodulin interacts with the platelet ADP receptor P2Y1.
The Biochemical journal 2006;398(3):339-43.
2006: Christian Gachet; Béatrice Hechler; christelle nonne; Jean-Pierre Cazenave; François Lanza; Boris Aleil
[Atherothrombosis: transposition of the models to the clinic and reciprocally].
Thérapie 2006;61(5):389-94.
2006: Maria P Abbracchio; Geoffrey Burnstock; Jean-Marie Boeynaems; Eric A Barnard; José L Boyer; Charles Kennedy; Gillian E Knight; Marta Fumagalli; Christian Gachet; Kenneth Alan Jacobson; Gary A Weisman
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.
Pharmacological reviews 2006;58(3):281-341.
2006: Valerie Schulte; H Peter Reusch; Miroslava Pozgajová; David Varga-Szabó; Christian Gachet; Bernhard Nieswandt
Two-phase antithrombotic protection after anti-glycoprotein VI treatment in mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):1640-7.
2006: Mickael Lesurtel; Rolf Graf; Boris Aleil; Diego J Walther; Yinghua Tian; Wolfram Jochum; Christian Gachet; Michael Bader; Pierre-Alain Clavien
Platelet-derived serotonin mediates liver regeneration.
Science (New York, N.Y.) 2006;312(5770):104-7.
2006: Christian Gachet; Catherine Léon; Béatrice Hechler
The platelet P2 receptors in arterial thrombosis.
Blood cells, molecules & diseases 2006;36(2):223-7.
2006: Santosh K Mishra; Norbert Braun; Varsha Shukla; Marc Füllgrabe; Christof Schomerus; Horst-Werner Korf; Christian Gachet; Yukio Ikehara; Jean Sévigny; Simon C Robson; Herbert Zimmermann
Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation.
Development (Cambridge, England) 2006;133(4):675-84.
2006: Béatrice Hechler; christelle nonne; Eun Joo Roh; Marco Cattaneo; Jean-Pierre Cazenave; François Lanza; Kenneth Alan Jacobson; Christian Gachet
MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice.
The Journal of pharmacology and experimental therapeutics 2006;316(2):556-63.
2006: Catherine Strassel; Tovo David; Anita Eckly; Marie-Jeanne Baas; Sylvie Moog; Catherine Ravanat; Marie C Trzeciak; Christine Vinciguerra; Jean-Pierre Cazenave; Christian Gachet; François Lanza
Synthesis of GPIb beta with novel transmembrane and cytoplasmic sequences in a Bernard-Soulier patient resulting in GPIb-defective signaling in CHO cells.
Journal of thrombosis and haemostasis : JTH 2006;4(1):217-28.
2006: Christian Gachet
Regulation of platelet functions by P2 receptors.
Annual review of pharmacology and toxicology 2006;46():277-300.
2006: Valerie Tanneur; Christophe Duranton; Verena B Brand; Ciprian D Sandu; Canan Akkaya; Ravi S Kasinathan; Christian Gachet; Ronald Sluyter; Julian A Barden; James S Wiley; Florian Lang; Stephan M Huber
Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(1):133-5.
2005: Christian Gachet
The platelet P2 receptors as molecular targets for old and new antiplatelet drugs.
Pharmacology & therapeutics 2005;108(2):180-92.
2005: Boris Aleil; Nicolas Meyer; Jean-Pierre Cazenave; Jean-Marie Mossard; Christian Gachet
High stability of blood samples for flow cytometric analysis of VASP phosphorylation to measure the clopidogrel responsiveness in patients with coronary artery disease.
Thrombosis and haemostasis 2005;94(4):886-7.
2005: Carine Soulet; Béatrice Hechler; Marie-Pierre Gratacap; Monique Plantavid; Stefan Offermanns; Christian Gachet; Bernard Payrastre
A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation.
Journal of thrombosis and haemostasis : JTH 2005;3(10):2296-306.
2005: Philippe Ohlmann; Anita Eckly; Pierre Mangin; François Lanza; Christian Gachet
Further evidence that fibrillar collagen is unable to promote platelet shape change and aggregation in the absence of secondary agonists.
Journal of thrombosis and haemostasis : JTH 2005;3(9):2119-21.
2005: Gwen Tolhurst; Catherine Vial; Catherine Léon; Christian Gachet; Richard J Evans; Martyn P Mahaut-Smith
Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling.
Blood 2005;106(5):1644-51.
2005: Béatrice Hechler; Stéphanie Magnenat; Maddalena L Zighetti; Matthias U Kassack; Heiko Ullmann; Jean-Pierre Cazenave; Richard Evans; Marco Cattaneo; Christian Gachet
Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt].
The Journal of pharmacology and experimental therapeutics 2005;314(1):232-43.
2005: Catherine Léon; Monique Freund; Olivier Latchoumanin; Anne Farret; Pierre Petit; Jean-Pierre Cazenave; Christian Gachet
The P2Y(1) receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice.
Purinergic signalling 2005;1(2):145-51.
2005: Jean-Pierre Cazenave; Hervé Isola; Christian Gachet; Boris Aleil
[Progress in transfusion for storage of platelets].
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 2005;12(2):226-9.
2005: christelle nonne; Nadège Lenain; Béatrice Hechler; Pierre Mangin; Jean-Pierre Cazenave; Christian Gachet; François Lanza
Importance of platelet phospholipase Cgamma2 signaling in arterial thrombosis as a function of lesion severity.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(6):1293-8.
2005: Christian Gachet; Béatrice Hechler
The platelet P2 receptors in thrombosis.
Seminars in thrombosis and hemostasis 2005;31(2):162-7.
2005: Béatrice Hechler; Marco Cattaneo; Christian Gachet
The P2 receptors in platelet function.
Seminars in thrombosis and hemostasis 2005;31(2):150-61.
2005: Christian Gachet; Boris Aleil
[The inter-individual variability of the response to clopidogrel].
Archives des maladies du coeur et des vaisseaux 2005;98(3):216-25.
2005: Anthony Baurand; Anita Eckly; Béatrice Hechler; Gilles kauffenstein; Jean-Luc Galzi; Jean-Pierre Cazenave; Catherine Léon; Christian Gachet
Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?
Molecular pharmacology 2005;67(3):721-33.
2005: Stephane Bodin; Carine Soulet; Hélène Tronchère; Pierre Sié; Christian Gachet; Monique Plantavid; Bernard Payrastre
Integrin-dependent interaction of lipid rafts with the actin cytoskeleton in activated human platelets.
Journal of cell science 2005;118(Pt 4):759-69.
2005: Juan Martinez-Pinna; Iman S Gurung; Catherine Vial; Catherine Leon; Christian Gachet; Richard J Evans; Martyn P Mahaut-Smith
Direct voltage control of signaling via P2Y1 and other Galphaq-coupled receptors.
The Journal of biological chemistry 2005;280(2):1490-8.
2005: Boris Aleil; Catherine Ravanat; Jean-Pierre Cazenave; G Rochoux; A Heitz; Christian Gachet
Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases.
Journal of thrombosis and haemostasis : JTH 2005;3(1):85-92.
2005: Maria P Abbracchio; Geoffrey Burnstock; Jean-Marie Boeynaems; Eric A Barnard; José L Boyer; Charles Kennedy; M Teresa Miras-Portugal; Brian F King; Christian Gachet; Kenneth Alan Jacobson; Gary A Weisman
The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor.
Trends in pharmacological sciences 2005;26(1):8-9.
2004: Masahito Kawamura; Christian Gachet; Kazuhide Inoue; Fusao Kato
Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y1 receptors in the hippocampal slice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(48):10835-45.
2004: Gilles kauffenstein; Béatrice Hechler; Jean-Pierre Cazenave; Christian Gachet
Adenine triphosphate nucleotides are antagonists at the P2Y receptor.
Journal of thrombosis and haemostasis : JTH 2004;2(11):1980-8.
2004: Jennifer A Calvert; Amelia E Atterbury-Thomas; Catherine Leon; Ian D Forsythe; Christian Gachet; Richard J Evans
Evidence for P2Y1, P2Y2, P2Y6 and atypical UTP-sensitive receptors coupled to rises in intracellular calcium in mouse cultured superior cervical ganglion neurons and glia.
British journal of pharmacology 2004;143(5):525-32.
2004: Pierre Mangin; Tovo David; Vincent Lavaud; Susan L Cranmer; Inna Pikovski; Shaun P Jackson; Michael C Berndt; Jean-Pierre Cazenave; Christian Gachet; François Lanza
Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha.
Blood 2004;104(2):420-7.
2004: Pierre Mangin; Philippe Ohlmann; Anita Eckly; Jean-Pierre Cazenave; François Lanza; Christian Gachet
The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented.
Journal of thrombosis and haemostasis : JTH 2004;2(6):969-77.
2004: Romain Mathieu; Anthony Baurand; Martine Schmitt; Christian Gachet; Jean-Jacques Bourguignon
Synthesis and biological activity of 2-alkylated deoxyadenosine bisphosphate derivatives as P2Y(1) receptor antagonists.
Bioorganic & medicinal chemistry 2004;12(7):1769-79.
2004: Nadine Haserück; Wolfgang Erl; Dharmendra Pandey; Gabor Tigyi; Philippe Ohlmann; Catherine Ravanat; Christian Gachet; Wolfgang Siess
The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors.
Blood 2004;103(7):2585-92.
2004: Catherine Leon; Meike Alex; Antje Klocke; Eberhard Morgenstern; Christine Moosbauer; Anita Eckly; Michael Spannagl; Christian Gachet; Bernd Engelmann
Platelet ADP receptors contribute to the initiation of intravascular coagulation.
Blood 2004;103(2):594-600.
2004: Philippe Ohlmann; Béatrice Hechler; Jean-Pierre Cazenave; Christian Gachet
Measurement and manipulation of [Ca2+]i in suspensions of platelets and cell cultures.
Methods in molecular biology (Clifton, N.J.) 2004;273():229-50.
2004: Jean-Pierre Cazenave; Philippe Ohlmann; Dominique Cassel; Anita Eckly; Béatrice Hechler; Christian Gachet
Preparation of washed platelet suspensions from human and rodent blood.
Methods in molecular biology (Clifton, N.J.) 2004;272():13-28.
2003: Catherine Leon; Catherine Ravanat; Monique Freund; Jean-Pierre Cazenave; Christian Gachet
Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1941-7.
2003: Pierre Mangin; Yuping Yuan; Isaac Goncalves; Anita Eckly; Monique Freund; Jean-Pierre Cazenave; Christian Gachet; Shaun P Jackson; François Lanza
Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.
The Journal of biological chemistry 2003;278(35):32880-91.
2003: Béatrice Hechler; Nadège Lenain; Patrizia Marchese; Catherine Vial; Véronique Heim; Monique Freund; Jean-Pierre Cazenave; Marco Cattaneo; Zaverio M Ruggeri; Richard Evans; Christian Gachet
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo.
The Journal of experimental medicine 2003;198(4):661-7.
2003: Tomoko Moriyama; Tohko Iida; Kimiko Kobayashi; Tomohiro Higashi; Tetsuo Fukuoka; Hideki Tsumura; Catherine Leon; Noboru Suzuki; Kazuhide Inoue; Christian Gachet; Koichi Noguchi; Makoto Tominaga
Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(14):6058-62.
2003: Nadège Lenain; Monique Freund; Catherine Léon; Jean-Pierre Cazenave; Christian Gachet
Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.
Journal of thrombosis and haemostasis : JTH 2003;1(6):1144-9.
2003: Pierre Mangin; christelle nonne; Anita Eckly; Philippe Ohlmann; Monique Freund; Bernhard Nieswandt; Jean-Pierre Cazenave; Christian Gachet; François Lanza
A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1.
FEBS letters 2003;542(1-3):53-9.
2003: Maria P Abbracchio; Jean-Marie Boeynaems; Eric A Barnard; José L Boyer; Charles Kennedy; M Teresa Miras-Portugal; Brian F King; Christian Gachet; Kenneth Alan Jacobson; Gary A Weisman; Geoffrey Burnstock
Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.
Trends in pharmacological sciences 2003;24(2):52-5.
2003: Jean-Pierre Cazenave; Christian Gachet; François Lanza; Marie-Louise Wiesel
[Platelets and arterial thrombosis].
Bulletin de l'Académie nationale de médecine 2003;187(1):35-44; discussion 45-6.
2003: Béatrice Hechler; Y Zhang; Anita Eckly; Jean-Pierre Cazenave; Christian Gachet; Katya Ravid
Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice.
Journal of thrombosis and haemostasis : JTH 2003;1(1):155-63.
2003: Anthony Baurand; Christian Gachet
The P2Y(1) receptor as a target for new antithrombotic drugs: a review of the P2Y(1) antagonist MRS-2179.
Cardiovascular drug reviews 2003;21(1):67-76.
2002: Pierre Raboisson; Anthony Baurand; Jean-Pierre Cazenave; Christian Gachet; Dominique Schultz; Bernard Spiess; Jean-Jacques Bourguignon
A general approach toward the synthesis of C-nucleoside pyrazolo[1,5-a]-1,3,5-triazines and their 3',5'-bisphosphate C-nucleotide analogues as the first reported in vivo stable P2Y(1)-receptor antagonists.
The Journal of organic chemistry 2002;67(23):8063-71.
2002: Marco Cattaneo; Christian Gachet; Jeanne-Pierre Cazenave; Marian A Packham
Adenosine diphosphate(ADP) does not induce thromboxane A2 generation in human platelets.
Blood 2002;99(10):3868-9; author reply 3869-70.
2002: Claude Leray; Jean-Pierre Cazenave; Christian Gachet
Platelet phospholipids are differentially protected against oxidative degradation by plasmalogens.
Lipids 2002;37(3):285-90.
2002: Pierre Raboisson; Anthony Baurand; Jean-Pierre Cazenave; Christian Gachet; Myriam Retat; Bernard Spiess; Jean-Jacques Bourguignon
Novel antagonists acting at the P2Y(1) purinergic receptor: synthesis and conformational analysis using potentiometric and nuclear magnetic resonance titration techniques.
Journal of medicinal chemistry 2002;45(4):962-72.
2001: Béatrice Hechler; Paul Toselli; Catherine Ravanat; Christian Gachet; Katya Ravid
Mpl ligand increases P2Y1 receptor gene expression in megakaryocytes with no concomitant change in platelet response to ADP.
Molecular pharmacology 2001;60(5):1112-20.
2001: Gilles kauffenstein; Wolfgang Bergmeier; Anita Eckly; Philippe Ohlmann; Catherine Léon; Jean-Pierre Cazenave; Bernhard Nieswandt; Christian Gachet
The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism.
FEBS letters 2001;505(2):281-90.
2001: Sylvie Moog; Pierre Mangin; Nadège Lenain; Catherine Strassel; Catherine Ravanat; Sandrine Schuhler; Monique Freund; Martine Santer; M Kahn; Bernhard Nieswandt; Christian Gachet; Jean-Pierre Cazenave; François Lanza
Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation.
Blood 2001;98(4):1038-46.
2001: Christian Gachet
ADP receptors of platelets and their inhibition.
Thrombosis and haemostasis 2001;86(1):222-32.
2001: Bernhard Nieswandt; Wolfgang Bergmeier; Anita Eckly; Valerie Schulte; Philippe Ohlmann; Jean-Pierre Cazenave; Hubert Zirngibl; Stefan Offermanns; Christian Gachet
Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.
Blood 2001;97(12):3829-35.
2001: Anita Eckly; J L Gendrault; Béatrice Hechler; Jean-Pierre Cazenave; Christian Gachet
Differential involvement of the P2Y1 and P2YT receptors in the morphological changes of platelet aggregation.
Thrombosis and haemostasis 2001;85(4):694-701.
2001: C Leray; ML Wiesel; Monique Freund; Jean-Pierre Cazenave; Christian Gachet
Long-chain n-3 fatty acids specifically affect rat coagulation factors dependent on vitamin K: relation to peroxidative stress.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(3):459-65.
2001: Bernhard Nieswandt; Valerie Schulte; Wolfgang Bergmeier; R Mokhtari-Nejad; K Rackebrandt; Jean-Pierre Cazenave; Philippe Ohlmann; Christian Gachet; Hubert Zirngibl
Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice.
The Journal of experimental medicine 2001;193(4):459-69.
2001: Catherine Léon; Monique Freund; Catherine Ravanat; Anthony Baurand; Jean-Pierre Cazenave; Christian Gachet
Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist.
Circulation 2001;103(5):718-23.
2001: Anthony Baurand; Pierre Raboisson; Monique Freund; Catherine Léon; Jean-Pierre Cazenave; Jean-Jacques Bourguignon; Christian Gachet
Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist.
European journal of pharmacology 2001;412(3):213-21.
2000: Sophie Caillard; C Leray; K Kunz; Christian Gachet; Maurice Offner; ML Wiesel; T Hannedouchte; Jean-Pierre Cazenave; Bruno Moulin
Effects of cerivastatin on lipid profiles, lipid peroxidation and platelet and endothelial activation in renal transplant recipients.
Transplantation proceedings 2000;32(8):2787-8.
2000: Marco Cattaneo; Anna Lecchi; Rossana Lombardi; Christian Gachet; Maddalena L Zighetti
Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2CYC receptors.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):E101-6.
2000: Philippe Ohlmann; Anita Eckly; Monique Freund; Jean-Pierre Cazenave; Stefan Offermanns; Christian Gachet
ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq.
Blood 2000;96(6):2134-9.
2000: Anthony Baurand; Anita Eckly; N Bari; Catherine Léon; Béatrice Hechler; Jean-Pierre Cazenave; Christian Gachet
Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors.
Thrombosis and haemostasis 2000;84(3):484-91.
2000: C Fayolle; C Leray; Philippe Ohlmann; G Gutbier; Jean-Pierre Cazenave; Christian Gachet; René Groscolas
Lipid composition of blood platelets and erythrocytes of southern elephant seal (Mirounga leonina) and antarctic fur seal (Arctocephalus gazella).
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2000;126(1):39-47.
2000: C Fayolle; C Leray; Philippe Ohlmann; G Gutbier; Jean-Pierre Cazenave; Christian Gachet; René Groscolas
Lipid composition of erythrocytes and thrombocytes of a subantarctic seabird, the king penguin.
Lipids 2000;35(4):453-9.
2000: Sophie Caillard; Arnaud Charpentier; C Ravannat; D Cassel; ML Wiesel; Bruno Moulin; Jean-Pierre Cazenave; Christian Gachet
Nucleotide metabolism and ADPase activity in cardiac and renal transplantation.
Transplantation proceedings 2000;32(2):466-7.
1999: C Trumel; Bernard Payrastre; Monique Plantavid; Béatrice Hechler; Cécile Viala; P Presek; E A Martinson; J P Cazenave; Hugues Chap; Christian Gachet
A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase.
Blood 1999;94(12):4156-65.
1999: Catherine Léon; Béatrice Hechler; Monique Freund; Anita Eckly; C Vial; Philippe Ohlmann; Andrée Dierich; Marianne LeMeur; Jean-Pierre Cazenave; Christian Gachet
Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice.
The Journal of clinical investigation 1999;104(12):1731-7.
1999: Marco Cattaneo; Christian Gachet
ADP receptors and clinical bleeding disorders.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(10):2281-5.
1999: Catherine Léon; C Vial; Christian Gachet; Philippe Ohlmann; Béatrice Hechler; Jean-Pierre Cazenave; A Lecchi; M Cattaneo
The P2Y1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation.
Thrombosis and haemostasis 1999;81(5):775-81.
1999: Paul Vigne; Béatrice Hechler; Christian Gachet; Jean-Philippe Breittmayer; Christian Frelin
Benzoyl ATP is an antagonist of rat and human P2Y1 receptors and of platelet aggregation.
Biochemical and biophysical research communications 1999;256(1):94-7.
1999: MD Andriamampandry; C Leray; Monique Freund; Jean-Pierre Cazenave; Christian Gachet
Antithrombotic effects of (n-3) polyunsaturated fatty acids in rat models of arterial and venous thrombosis.
Thrombosis research 1999;93(1):9-16.
1998: Béatrice Hechler; Anita Eckly; Philippe Ohlmann; Jean-Pierre Cazenave; Christian Gachet
The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel.
British journal of haematology 1998;103(3):858-66.
1998: C Leray; MD Andriamampandry; Monique Freund; Christian Gachet; Jean-Pierre Cazenave
Simultaneous determination of homologues of vitamin E and coenzyme Q and products of alpha-tocopherol oxidation.
Journal of lipid research 1998;39(10):2099-105.
1998: Béatrice Hechler; Catherine Léon; C Vial; Paul Vigne; Christian Frelin; Jean-Pierre Cazenave; Christian Gachet
The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation.
Blood 1998;92(1):152-9.
1998: MD Andriamampandry; Monique Freund; ML Wiesel; S Rhinn; Catherine Ravanat; Jean-Pierre Cazenave; C Leray; Christian Gachet
Diets enriched in (n-3) fatty acids affect rat coagulation factors dependent on vitamin K.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1998;321(5):415-21.
1998: Philippe Ohlmann; C Leray; Catherine Ravanat; A Hallia; D Cassel; Jean-Pierre Cazenave; Christian Gachet
cADP-ribose formation by blood platelets is not responsible for intracellular calcium mobilization.
The Biochemical journal 1998;331 ( Pt 2)():431-6.
1998: Béatrice Hechler; Paul Vigne; Catherine Léon; Jean-Philippe Breittmayer; Christian Gachet; Christian Frelin
ATP derivatives are antagonists of the P2Y1 receptor: similarities to the platelet ADP receptor.
Molecular pharmacology 1998;53(4):727-33.
1998: C Leray; Monique Freund; ML Wiesel; G Gutbier; Jean-Pierre Cazenave; Christian Gachet
Effects of clopidogrel and its inactive form, SR 25989, on plasma, liver and platelet lipids in the rat.
Platelets 1998;9(1):49-54.
1997: C Vial; Béatrice Hechler; Catherine Léon; Jean-Pierre Cazenave; Christian Gachet
Presence of P2X1 purinoceptors in human platelets and megakaryoblastic cell lines.
Thrombosis and haemostasis 1997;78(6):1500-4.
1997: C Leray; MD Andriamampandry; G Gutbier; J Cavadenti; Claudine Klein-Soyer; Christian Gachet; Jean-Pierre Cazenave
Quantitative analysis of vitamin E, cholesterol and phospholipid fatty acids in a single aliquot of human platelets and cultured endothelial cells.
Journal of chromatography. B, Biomedical sciences and applications 1997;696(1):33-42.
1997: Christian Gachet; Béatrice Hechler; Catherine Léon; C Vial; C Leray; Philippe Ohlmann; Jean-Pierre Cazenave
Activation of ADP receptors and platelet function.
Thrombosis and haemostasis 1997;78(1):271-5.
1997: Marco Cattaneo; Rossana Lombardi; Maddalena L Zighetti; Christian Gachet; P Ohlmann; J P Cazenave; Pier M Mannucci
Deficiency of (33P)2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thromboxane A2 production.
Thrombosis and haemostasis 1997;77(5):986-90.
1997: Christian Gachet; Bernard Payrastre; C Guinebault; C Trumel; P Ohlmann; G Mauco; J P Cazenave; Monique Plantavid; Hugues Chap
Reversible translocation of phosphoinositide 3-kinase to the cytoskeleton of ADP-aggregated human platelets occurs independently of Rho A and without synthesis of phosphatidylinositol (3,4)-bisphosphate.
The Journal of biological chemistry 1997;272(8):4850-4.
1997: Catherine Léon; Béatrice Hechler; C Vial; C Leray; Jean-Pierre Cazenave; Christian Gachet
The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells.
FEBS letters 1997;403(1):26-30.
1996: Catherine Léon; C Vial; Jean-Pierre Cazenave; Christian Gachet
Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.
Gene 1996;171(2):295-7.
1996: Christian Gachet; R Ennamany; O Kretz; Philippe Ohlmann; C Krause; Edmond CREPPY; G Dirheimer; J P Cazenave
Bolesatine induces agglutination of rat platelets and human erythrocytes and platelets in vitro.
Human & experimental toxicology 1996;15(1):26-9.
1995: Philippe Ohlmann; K L Laugwitz; Bernd Nürnberg; Karsten Spicher; Günter Schultz; Jean-Pierre Cazenave; Christian Gachet
The human platelet ADP receptor activates Gi2 proteins.
The Biochemical journal 1995;312 ( Pt 3)():775-9.
1995: Christian Gachet; Marco Cattaneo; Philippe Ohlmann; Béatrice Hechler; A Lecchi; J Chevalier; D Cassel; P M Mannucci; Jean-Pierre Cazenave
Purinoceptors on blood platelets: further pharmacological and clinical evidence to suggest the presence of two ADP receptors.
British journal of haematology 1995;91(2):434-44.
1995: C de la Salle; M J Baas; F Lanza; A Schwartz; Daniel Hanau; J Chevalier; Christian Gachet; M E Briquel; Jean-Pierre Cazenave
A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ib alpha associated with a variant of Bernard-Soulier syndrome (Nancy I).
British journal of haematology 1995;89(2):386-96.
1995: Christian Gachet; Anne L Astier; Henri de la Salle; C de la Salle; Wolf H Fridman; Jean-Pierre Cazenave; Daniel Hanau; Jean-Luc Teillaud
Release of Fc gamma RIIa2 by activated platelets and inhibition of anti-CD9-mediated platelet aggregation by recombinant Fc gamma RIIa2.
Blood 1995;85(3):698-704.
1995: Béatrice Hechler; Jean-Pierre Cazenave; D Hanau; Christian Gachet
Presence of functional P2T and P2U purinoceptors on the human megakaryoblastic cell line, Meg-01 characterization by functional and binding studies.
Nouvelle revue française d'hématologie 1995;37(4):231-40.
1994: R Bischoff; Y Cordier; Ulla rasmussen; Y Schlesinger; Christian Gachet; Michel Jaquinod; B Tripet; P C Chong; A Pavirani
Synthesis and characterization of photoactivatable peptide agonists of the human thrombin receptor.
FEBS letters 1994;349(2):301-6.
1994: Catherine Ravanat; Christian Gachet; J M Herbert; Sandrine Schuhler; J C Guillemot; F Uzabiaga; C Picard; Pascual Ferrara; Monique Freund; Jean-Pierre Cazenave
Rat platelets contain glycosylated and non-glycosylated forms of platelet factor 4. Identification and characterization by mass spectrometry.
European journal of biochemistry / FEBS 1994;223(1):203-10.
1993: Ulla rasmussen; Christian Gachet; Y Schlesinger; Daniel Hanau; Philippe Ohlmann; Ellen Van Obberghen-Schilling; Jacques Pouysségur; J P Cazenave; A Pavirani
A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets.
The Journal of biological chemistry 1993;268(19):14322-8.
1993: M Freund; F Mantz; P Nicolini; Christian Gachet; J Mulvihill; L Meyer; Alain Beretz; Jean-Pierre Cazenave
Experimental thrombosis on a collagen coated arterioarterial shunt in rats: a pharmacological model to study antithrombotic agents inhibiting thrombin formation and platelet deposition.
Thrombosis and haemostasis 1993;69(5):515-21.
1993: D A Schmitt; Philippe Ohlmann; Christian Gachet; J P Cazenave
Platelet shape change and protein phosphorylation induced by ADP and thrombin are not sensitive to short periods of microgravity.
Journal of cell science 1993;104 ( Pt 3)():805-10.
1993: Christian Gachet; Daniel Hanau; Danièle Spehner; C Brisson; J C Garaud; Daniel Schmitt; Philippe Ohlmann; Jean-Pierre Cazenave
Alpha IIb beta 3 integrin dissociation induced by EDTA results in morphological changes of the platelet surface-connected canalicular system with differential location of the two separate subunits.
The Journal of cell biology 1993;120(4):1021-30.
1992: Christian Gachet; Daniel Hanau; Danièle Spehner; C Brisson; Philippe Ohlmann; Daniel Schmitt; Jean-Pierre Cazenave
Alpha IIB beta 3 integrin dissociation induced by EDTA results in formation of Birbeck granule-like structures in human blood platelets.
The Journal of investigative dermatology 1992;99(5):27S-29S.
1992: Christian Gachet; Pierre Savi; Philippe Ohlmann; Jean-Pierre Maffrand; Karl H Jakobs; Jean-Pierre Cazenave
ADP receptor induced activation of guanine nucleotide binding proteins in rat platelet membranes--an effect selectively blocked by the thienopyridine clopidogrel.
Thrombosis and haemostasis 1992;68(1):79-83.
1992: Christian Gachet; Jean-Pierre Cazenave; Philippe Ohlmann; G Hilf; Thomas Wieland; Karl H Jakobs
ADP receptor-induced activation of guanine-nucleotide-binding proteins in human platelet membranes.
European journal of biochemistry / FEBS 1992;207(1):259-63.
1992: F Lanza; A Stierlé; Christian Gachet; Jean-Pierre Cazenave
Differential effects of extra- and intracellular calcium chelation on human platelet function and glycoprotein IIb-IIIa complex stability.
Nouvelle revue française d'hématologie 1992;34(1):123-31.
1992: Florian Toti; Christian Gachet; Philippe Ohlmann; A Stierlé; Lélia Grunebaum; M L Wiesel; Jean-Pierre Cazenave
Electrophoretic studies on molecular defects of von Willebrand factor and platelet glycoprotein IIb-IIIa with antibodies produced in egg yolk from laying hens.
Haemostasis 1992;22(1):32-40.
1991: Daniel Hanau; Christian Gachet; Daniel Schmitt; Philippe Ohlmann; C Brisson; M Fabre; Jean-Pierre Cazenave
Ultrastructural similarities between epidermal Langerhans cell Birbeck granules and the surface-connected canalicular system of EDTA-treated human blood platelets.
The Journal of investigative dermatology 1991;97(5):756-62.
1991: Christian Gachet; A Stierlé; Philippe Ohlmann; F Lanza; Daniel Hanau; Jean-Pierre Cazenave
Normal ADP-induced aggregation and absence of dissociation of the membrane GP IIb-IIIa complex of intact rat platelets pretreated with EDTA.
Thrombosis and haemostasis 1991;66(2):246-53.
1991: G Defreyn; Christian Gachet; Pierre Savi; F Driot; Jean-Pierre Cazenave; Jean-Pierre Maffrand
Ticlopidine and clopidogrel (SR 25990C) selectively neutralize ADP inhibition of PGE1-activated platelet adenylate cyclase in rats and rabbits.
Thrombosis and haemostasis 1991;65(2):186-90.
1991: Christian Gachet; Jean-Pierre Cazenave
ADP induced blood platelet activation: a review.
Nouvelle revue française d'hématologie 1991;33(5):347-58.
1990: Christian Gachet; Jean-Pierre Cazenave; Philippe Ohlmann; C Bouloux; G Defreyn; F Driot; Jean-Pierre Maffrand
The thienopyridine ticlopidine selectively prevents the inhibitory effects of ADP but not of adrenaline on cAMP levels raised by stimulation of the adenylate cyclase of human platelets by PGE1.
Biochemical pharmacology 1990;40(12):2683-7.
1990: Christian Gachet; A Stierlé; Jean-Pierre Cazenave; Philippe Ohlmann; F Lanza; C Bouloux; Jean-Pierre Maffrand
The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibrinogen binding without modifying the membrane glycoprotein IIb-IIIa complex in rat and in man.
Biochemical pharmacology 1990;40(2):229-38.