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Robert Gadski

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Liang Zeng Yan; Hansen M Hsiung; Mark L Heiman; Robert A Gadski; Paul J Emmerson; JeAnne Hertel; David B Flora; Patrick Edwards; David L Smiley; Lianshan Zhang; Saba Husain; Steven D Kahl; Richard D Dimarchi; John P Mayer
Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.
Cynthia D Jesudason; Lisa S Beavers; Jeffrey W Cramer; Joelle Dill; Don R Finley; Craig W Lindsley; F Craig Stevens; Robert A Gadski; Samuel W Oldham; Richard T Pickard; Christopher S Siedem; Dana K Sindelar; Ajay Singh; Brian M Watson; Philip A Hipskind
Synthesis and SAR of novel histamine H3 receptor antagonists.
Liang Zeng Yan; David B Flora; Patrick Edwards; David L Smiley; Paul J Emmerson; Hansen M Hsiung; Robert A Gadski; JeAnne Hertel; Mark L Heiman; Saba Husain; Thomas P O'Brien; Steven D Kahl; Lianshan Zhang; Richard D Dimarchi; John P Mayer
Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.

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All Publications

2007: Liang Zeng Yan; Hansen M Hsiung; Mark L Heiman; Robert A Gadski; Paul J Emmerson; JeAnne Hertel; David B Flora; Patrick Edwards; David L Smiley; Lianshan Zhang; Saba Husain; Steven D Kahl; Richard D Dimarchi; John P Mayer
Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.
Current topics in medicinal chemistry 2007;7(11):1052-67.
2006: Cynthia D Jesudason; Lisa S Beavers; Jeffrey W Cramer; Joelle Dill; Don R Finley; Craig W Lindsley; F Craig Stevens; Robert A Gadski; Samuel W Oldham; Richard T Pickard; Christopher S Siedem; Dana K Sindelar; Ajay Singh; Brian M Watson; Philip A Hipskind
Synthesis and SAR of novel histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(13):3415-8.
2005: Liang Zeng Yan; David B Flora; Patrick Edwards; David L Smiley; Paul J Emmerson; Hansen M Hsiung; Robert A Gadski; JeAnne Hertel; Mark L Heiman; Saba Husain; Thomas P O'Brien; Steven D Kahl; Lianshan Zhang; Richard D Dimarchi; John P Mayer
Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.
Bioorganic & medicinal chemistry letters 2005;15(20):4611-4.
2005: John P Mayer; Hansen M Hsiung; David B Flora; Patrick Edwards; Dennis P Smith; Xing-Yue Zhang; Robert A Gadski; Mark L Heiman; JeAnne Hertel; Paul J Emmerson; Saba Husain; Thomas P O'Brien; Steven D Kahl; David L Smiley; Lianshan Zhang; Richard D Dimarchi; Liang Zeng Yan
Discovery of a beta-MSH-derived MC-4R selective agonist.
Journal of medicinal chemistry 2005;48(9):3095-8.
2004: Dana K Sindelar; Mary L Shepperd; Richard T Pickard; Jesline Alexander-Chacko; M Joelle Dill; Jeffrey W Cramer; Dennis P Smith; Robert A Gadski
Central H3R activation by thioperamide does not affect energy balance.
Pharmacology, biochemistry, and behavior 2004;78(2):275-83.
2001: Helena Corominola; Laura Conner; Lisa S Beavers; Robert A Gadski; D Johnson; JF Caro; Ronit Rafaeloff-Phail
Identification of novel genes differentially expressed in omental fat of obese subjects and obese type 2 diabetic patients.
Diabetes 2001;50(12):2822-30.
2001: Donald R Gehlert; P Yang; C George; Yi Wang; Douglas A Schober; Susan L Gackenheimer; D Johnson; Lisa S Beavers; Robert A Gadski; Melvyn Baez
Cloning and characterization of Rhesus monkey neuropeptide Y receptor subtypes.
Peptides 2001;22(3):343-50.
2000: Michael A Statnick; Lisa S Beavers; Laura Conner; Helena Corominola; D Johnson; C D Hammond; Ronit Rafaeloff-Phail; Thomas W Seng; Todd M Suter; James Sluka; E Ravussin; Robert A Gadski; JF Caro
Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes.
International journal of experimental diabetes research 2000;1(2):81-8.
1999: Ho-Shen Lin; AA Rampersaud; Lisa S Beavers; DB McClure; A J Gardner; Patrick I Eacho; Patricia Foxworthy; Robert A Gadski
Synthesis and in vitro biological activity of 4alpha-(2-propenyl)-5alpha-cholest-24-en-3alpha,12 alpha-diol, a 12alpha-hydroxyl analog of 4alpha-(2-propenyl)-5alpha-cholest-24-en-3alpha-ol: the latter is a potent activator of the low-density lipoprotein receptor promoter.
Steroids 1999;64(10):735-41.
1999: William R Bensch; Robert A Gadski; James S Bean; Lisa S Beavers; Robert J Schmidt; D N Perry; A T Murphy; DB McClure; Patrick I Eacho; A P Breau; R A Archer; Raymond F Kauffman
Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters.
The Journal of pharmacology and experimental therapeutics 1999;289(1):85-92.
1999: Ho-Shen Lin; AA Rampersaud; Michael E Richett; RW Harper; Lisa S Beavers; DB McClure; A J Gardner; Patrick I Eacho; Patricia Foxworthy; Robert A Gadski
Synthesis and in vitro biological activity of 4alpha-(2-propenyl)-5alpha-cholest-24-en-3alpha-ol: a 24,25-dehydro analog of the hypocholesterolemic agent 4alpha-(2-propenyl)-5alpha-cholestan-3alpha-ol.
Steroids 1999;64(3):217-27.
1998: Michael A Statnick; Douglas A Schober; Susan L Gackenheimer; D Johnson; Lisa S Beavers; NG Mayne; JP Burnett; Robert A Gadski; Donald R Gehlert
Characterization of the neuropeptide Y5 receptor in the human hypothalamus: a lack of correlation between Y5 mRNA levels and binding sites.
Brain research 1998;810(1-2):16-26.
1998: Ho-Shen Lin; AA Rampersaud; Michael E Richett; Lisa S Beavers; DB McClure; Robert A Gadski
Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol.
Steroids 1998;63(4):202-7.
1997: Donald R Gehlert; Douglas A Schober; Susan L Gackenheimer; Lisa S Beavers; Robert A Gadski; Ingrid Lundell; Dan Larhammar
[125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Peptides 1997;18(3):397-401.
1996: Donald R Gehlert; Susan L Gackenheimer; Douglas A Schober; Lisa S Beavers; Robert A Gadski; JP Burnett; NG Mayne; Ingrid Lundell; Dan Larhammar
The neuropeptide Y Y1 receptor selective radioligand, [125I][Leu31,Pro34]peptide YY, is also a high affinity radioligand for human pancreatic polypeptide 1 receptors.
European journal of pharmacology 1996;318(2-3):485-90.
1996: Nancy L Bowling; W F Matter; Robert A Gadski; DB McClure; T Schreyer; P A Dawson; chris vlahos
LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins.
Journal of lipid research 1996;37(12):2586-98.
1996: Donald R Gehlert; Douglas A Schober; Lisa S Beavers; Robert A Gadski; J A Hoffman; D L Smiley; Ronald E Chance; Ingrid Lundell; Dan Larhammar
Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor.
Molecular pharmacology 1996;50(1):112-8.
1996: Donald R Gehlert; Lisa S Beavers; D Johnson; Susan L Gackenheimer; Douglas A Schober; Robert A Gadski
Expression cloning of a human brain neuropeptide Y Y2 receptor.
Molecular pharmacology 1996;49(2):224-8.
1995: Ingrid Lundell; A G Blomqvist; Magnus M Berglund; Douglas A Schober; D Johnson; Michael A Statnick; Robert A Gadski; Donald R Gehlert; Dan Larhammar
Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
The Journal of biological chemistry 1995;270(49):29123-8.
1990: James J Starling; R S Maciak; N A Hinson; J Hoskins; B C Laguzza; Robert A Gadski; J Strnad; L Rittmann-Grauer; S V DeHerdt; T F Bumol
In vivo selection of human tumor cells resistant to monoclonal antibody-Vinca alkaloid immunoconjugates.
Cancer research 1990;50(23):7634-40.
1989: B Landgraf; Fred Cohen; Kendall A Smith; Robert A Gadski; Thomas L Ciardelli
Structural significance of the C-terminal amphiphilic helix of interleukin-2.
The Journal of biological chemistry 1989;264(2):816-22.
1989: J Strnad; A E Hamilton; Lisa S Beavers; G C Gamboa; L D Apelgren; L D Taber; J Richard Sportsman; T F Bumol; J D Sharp; Robert A Gadski
Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA.
Cancer research 1989;49(2):314-7.
1988: Thomas L Ciardelli; B Landgraf; Robert A Gadski; J Strnad; Fred Cohen; Kendall A Smith
A design approach to the structural analysis of interleukin-2.
Journal of molecular recognition : JMR 1988;1(1):42-7.