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Matthias Gaestel

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Thomas Hochdörfer; Perry J Blackshear; Matthias Gaestel; Deborah J Stumpo; Christopher Tiedje; Michael Huber
LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP.
Tobias Braun; Jörg H W Distler; Matthias Gaestel; Willy Hofstetter; Klaus Klaushofer; Johannes Lepper; Patrick Lezuo; Gisela Ruiz Heiland; Monika Rumpler; Georg Schett; Mark Siegrist; Roman Thaler; Jochen Zwerina
Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover.
Karl Katholnig; Caroline Lassnig; Mathias Müller; Jin Mo Park; Margit Rosner; Marcus D Säemann; Matthias Gaestel; Hiroko Hayakawa; Markus Hengstschläger; Walter H Hörl; Christopher C Kaltenecker; Gerhard J Zlabinger; Thomas Weichhart
p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin.

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2013: Thomas Hochdörfer; Perry J Blackshear; Matthias Gaestel; Deborah J Stumpo; Christopher Tiedje; Michael Huber
LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP.
Cellular signalling 2013;25(6):1339-47.
2013: Tobias Braun; Jörg H W Distler; Matthias Gaestel; Willy Hofstetter; Klaus Klaushofer; Johannes Lepper; Patrick Lezuo; Gisela Ruiz Heiland; Monika Rumpler; Georg Schett; Mark Siegrist; Roman Thaler; Jochen Zwerina
Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(4):936-47.
2013: Karl Katholnig; Caroline Lassnig; Mathias Müller; Jin Mo Park; Margit Rosner; Marcus D Säemann; Matthias Gaestel; Hiroko Hayakawa; Markus Hengstschläger; Walter H Hörl; Christopher C Kaltenecker; Gerhard J Zlabinger; Thomas Weichhart
p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(4):1519-27.
2013: Adam J Guess; Jeffrey B Kopp; Joshua Manley; Ruma Pengal; Amy L Pyle; Natalia Ronkina; Shipra Agrawal; Rose Ayoob; Brian Becknell; Rainer Benndorf; Mariana M Cajaiba; Melinda Chanley; Matthias Gaestel; William E Smoyer
Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis.
PloS one 2013;8(1):e54239.
2012: Katja Höpker; Safiya Khurshid; Tülay Kisner; Peter Kurschat; Tobias Lamkemeyer; Max C Liebau; Drew Lowery; René H Medema; Roman Ulrich Müller; H Christian Reinhardt; Ulrike Resch; Frederik Roels; Fabian Röther; Bernhard Schermer; Katharina Schilberg; Björn Schumacher; Tamina Seeger-Nukpezah; Martin L Sos; Roman K Thomas; Michael B Yaffe; Shuhua Chen; Francesca Fabretti; Matthias Fischer; Matthias Gaestel; Henning Hagmann; Pia Hasskamp; Lukas Heukamp; Malte P Bartram; Thomas Benzing
AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.
The EMBO journal 2012;31(20):3961-75.
2012: Alba Llopis; Angel R Nebreda; Noelia Salvador; Ivan del Barco Barrantes; Roger J Davis; Amaia Ercilla; Matthias Gaestel; Sandra Guaita-Esteruelas; Jalaj Gupta; Neus Agell
The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest.
Cell cycle (Georgetown, Tex.) 2012;11(19):3627-37.
2012: Christopher Tiedje; Sonam Dhamija; Helmut Holtmann; Alexey Kotlyarov; Kathrin Laass; Natalia Ronkina; Mohammad Tehrani; Matthias Gaestel
The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.
PLoS genetics 2012;8(9):e1002977.
2012: Frank Brand; Stefan Britsch; Matthias Gaestel; Shashi Kant; Sylvain Meloche; Manoj B Menon; Stefanie Schumacher; Ruth Simon; Benjamin Turgeon; Alexey Kotlyarov
The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.
Molecular and cellular biology 2012;32(13):2467-78.
2012: Matthias Gaestel; Alexey Kotlyarov
Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation.
Methods in molecular biology (Clifton, N.J.) 2012;795():35-44.
2011: M Lienhard Schmitz; Axel Weber; Matthias Gaestel; Thomas Roxlau; Michael Kracht
Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines.
Biochimica et biophysica acta 2011;1813(12):2165-75.
2011: Ratnesh K Srivastav; Matthias Gaestel; Malte Klaus; Susan Schwede; Jessica Schwermann; Rainer Niedenthal
Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation.
The Biochemical journal 2011;438(3):495-503.
2011: Christian Ehlting; Matthias Gaestel; Dieter Häussinger; Alexey Kotlyarov; Karl S Lang; Danuta Radzioch; Natalia Ronkina; Ute Albrecht; Konrad A Bode; Oliver Böhmer; Johannes Bode
Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.
The Journal of biological chemistry 2011;286(27):24113-24.
2011: Theresia R Kress; Ian Cannell; Arjan B Brenkman; Birgit Samans; Matthias Gaestel; Paul Roepman; Boudewijn M Burgering; Martin Bushell; Andreas Rosenwald; Martin Eilers
The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.
Molecular cell 2011;41(4):445-57.
2011: Téni G Ebrahimian; Melissa Wei Li; Catherine A Lemarié; Stefania M C Simeone; Patrick J Pagano; Matthias Gaestel; Pierre Paradis; Sven Wassmann; Ernesto L Schiffrin
Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress.
Hypertension 2011;57(2):245-54.
2011: Manoj B Menon; Alexey Kotlyarov; Matthias Gaestel
SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition.
PloS one 2011;6(8):e23054.
2010: Natalia Ronkina; manoj menon; Jessica Schwermann; Christopher Tiedje; Edward Hitti; Alexey Kotlyarov; Matthias Gaestel
MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin.
Biochemical pharmacology 2010;80(12):1915-20.
2010: Christopher Tiedje; Alexey Kotlyarov; Matthias Gaestel
Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins.
Biochemical Society transactions 2010;38(6):1632-7.
2010: manoj menon; Jessica Schwermann; Anurag Kumar Singh; Mirita Franz-Wachtel; Oliver Pabst; Ursula Seidler; M Bishr Omary; Alexey Kotlyarov; Matthias Gaestel
p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.
The Journal of biological chemistry 2010;285(43):33242-51.
2010: Nader Ghasemlou; Ruben Lopez-Vales; Claude Lachance; Thusanth Thuraisingam; Matthias Gaestel; Danuta Radzioch; Samuel David
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(41):13750-9.
2010: Nadège Moïse; Dharmendra Dingar; Aida M Mamarbachi; Louis Villeneuve; Nada Farhat; Matthias Gaestel; Maya Khairallah; Bruce G Allen
Characterization of a novel MK3 splice variant from murine ventricular myocardium.
Cellular signalling 2010;22(10):1502-12.
2010: Christina Luig; Katharina Köther; Sabine Eva Dudek; Matthias Gaestel; John Hiscott; Viktor Wixler; Stephan Ludwig
MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):4068-77.
2010: Tiegang Liu; Oscar E Guevara; Rod R Warburton; Nicholas S Hill; Matthias Gaestel; Usamah S Kayyali
Regulation of vimentin intermediate filaments in endothelial cells by hypoxia.
American journal of physiology. Cell physiology 2010;299(2):C363-73.
2010: Matthias Gaestel
Biological monitoring of non-thermal effects of mobile phone radiation: recent approaches and challenges.
Biological reviews of the Cambridge Philosophical Society 2010;85(3):489-500.
2010: Dharmendra Dingar; Marie-Josée Benoit; Aida M Mamarbachi; Louis Villeneuve; Marc-Antoine Gillis; Scott Grandy; Matthias Gaestel; Céline Fiset; Bruce G Allen
Characterization of the expression and regulation of MK5 in the murine ventricular myocardium.
Cellular signalling 2010;22(7):1063-75.
2010: Petra Gais; Christopher Tiedje; Felicitas Altmayr; Matthias Gaestel; Heike Weighardt; Bernhard Holzmann
TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5842-8.
2010: Ian Cannell; Yi W Kong; Samantha J Johnston; Melissa L Chen; Hilary M Collins; Helen C Dobbyn; Androulla Elia; Theresia R Kress; Martin Dickens; Michael J Clemens; David M Heery; Matthias Gaestel; Martin Eilers; Anne E Willis; Martin Bushell
p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5375-80.
2010: Simone Radtke; Stefan Wüller; Xiang-ping Yang; Barbara E Lippok; Barbara Mütze; Christine Mais; Hildegard Schmitz-Van de Leur; Johannes Bode; Matthias Gaestel; Peter C Heinrich; Iris Behrmann; Fred Schaper; Heike M Hermanns
Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation.
Journal of cell science 2010;123(Pt 6):947-59.
2010: Arndt Schottelius; Ulrich Zügel; Wolf-Dietrich Döcke; Thomas M Zollner; Lars Röse; Anne Mengel; Bernd Buchmann; Andreas Becker; Gerald Grütz; Sandra Naundorf; Anke Friedrich; Matthias Gaestel; Khusru Asadullah
The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-alpha pathway of systemic and cutaneous inflammation.
The Journal of investigative dermatology 2010;130(2):481-91.
2010: Kristian Otkjaer; Helmut Holtmann; Tue Wenzel Kragstrup; Søren R Paludan; Claus Johansen; Matthias Gaestel; Knud Kragballe; Lars Iversen
The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA.
PloS one 2010;5(1):e8671.
2010: Thusanth Thuraisingam; Yong Zhong Xu; Kalyn Eadie; Mitra Heravi; Marie-Cristine Guiot; Rony Greemberg; Matthias Gaestel; Danuta Radzioch
MAPKAPK-2 signaling is critical for cutaneous wound healing.
The Journal of investigative dermatology 2010;130(1):278-86.
2009: Claus Johansen; Christian Vestergaard; Knud Kragballe; George Kollias; Matthias Gaestel; Lars Iversen
MK2 regulates the early stages of skin tumor promotion.
Carcinogenesis 2009;30(12):2100-8.
2009: Tiegang Liu; Oscar E Guevara; Rod R Warburton; Nicholas S Hill; Matthias Gaestel; Usamah S Kayyali
Modulation of HSP27 alters hypoxia-induced endothelial permeability and related signaling pathways.
Journal of cellular physiology 2009;220(3):600-10.
2009: Diana A Gorog; Rita I Jabr; Masaya Tanno; Negin Sarafraz; James E Clark; Simon G Fisher; Xou Bin Cao; Mohamed Bellahcene; Kushal Dighe; Alamgir M N Kabir; Roy A Quinlan; Kanefusa Kato; Matthias Gaestel; Michael S Marber; Richard J Heads
MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia.
Cell stress & chaperones 2009;14(5):477-89.
2009: Corina Tudor; Francesco P Marchese; Edward Hitti; Anna Aubareda; Lesley Rawlinson; Matthias Gaestel; Perry Blackshear; Andrew R Clark; Jeremy Saklatvala; Jonathan L E Dean
The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages.
FEBS letters 2009;583(12):1933-8.
2009: Jianzhong Zhu; Xianzhu Wu; Suchi Goel; Nagaraj Gowda; Sanjeev Kumar; Gowdahalli Krishnegowda; GOURAV MISHRA; Rebecca Weinberg; Guangfu Li; Matthias Gaestel; Tatsushi Muta; D Channe Gowda
MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-induced production of tumor necrosis factor-{alpha} and interleukin-12 in macrophages.
The Journal of biological chemistry 2009;284(23):15750-61.
2009: Matthias Gaestel; Alexey Kotlyarov; Michael Kracht
Targeting innate immunity protein kinase signalling in inflammation.
Nature reviews. Drug discovery 2009;8(6):480-99.
2009: Jessica Schwermann; Chozhavendan Rathinam; Maria Schubert; Stefanie Schumacher; Fatih Noyan; Haruhiko Koseki; Alexey Kotlyarov; Christoph Klein; Matthias Gaestel
MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.
The EMBO journal 2009;28(10):1392-406.
2009: Susie S Mikkelsen; Søren B Jensen; Srikanth Chiliveru; Jesper Melchjorsen; Ilkka Julkunen; Matthias Gaestel; J Simon C Arthur; Richard A Flavell; Sankar Ghosh; Søren R Paludan
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
The Journal of biological chemistry 2009;284(16):10774-82.
2009: Anne T Funding; Claus Johansen; Matthias Gaestel; Bo M Bibby; Louise L Lilleholt; Knud Kragballe; Lars Iversen
Reduced oxazolone-induced skin inflammation in MAPKAP kinase 2 knockout mice.
The Journal of investigative dermatology 2009;129(4):891-8.
2009: Susan Zimnik; Matthias Gaestel; Rainer Niedenthal
Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation.
Nucleic acids research 2009;37(4):e30.
2009: Julia Skokowa; Dan Lan; Basant Kumar Thakur; Fei Wang; Kshama Gupta; Gunnar Cario; Annette Müller Brechlin; Axel Schambach; Lars Hinrichsen; Gustav Meyer; Matthias Gaestel; Martin Stanulla; Qiang Tong; Karl Welte
NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.
Nature medicine 2009;15(2):151-8.
2009: Matthias Gaestel; Michael Kracht
Peptides as signaling inhibitors for mammalian MAP kinase cascades.
Current pharmaceutical design 2009;15(21):2471-80.
2009: Mahendra Damarla; Emile Hasan; Adel Boueiz; Anne Le; Hyun Hae Pae; Calypso Montouchet; Todd Matthew Kolb; Tiffany Simms; Allen C Myers; Usamah S Kayyali; Matthias Gaestel; Xinqi Peng; SEKHAR POTHIREDDY; rachel damico; Paul M Hassoun
Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury.
PloS one 2009;4(2):e4600.
2008: Tobias Thomas; Edward Hitti; Alexey Kotlyarov; Heidrun Potschka; Matthias Gaestel
MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization.
The European journal of neuroscience 2008;28(4):642-54.
2008: Tobias Thomas; Marco Timmer; Konstantin Cesnulevicius; Edward Hitti; Alexey Kotlyarov; Matthias Gaestel
MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation--relevance in a mouse model of Parkinson's disease.
Journal of neurochemistry 2008;105(5):2039-52.
2008: Joon-Keun Park; Natalia Ronkina; Andreas Höft; Corinna Prohl; Jan Menne; Matthias Gaestel; Hermann Haller; Matthias Meier
Deletion of MK2 signalling in vivo inhibits small Hsp phosphorylation but not diabetic nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(6):1844-53.
2008: Heidi Mendoza; David G Campbell; Kerry Burness; James Hastie; Natalia Ronkina; Jae-Hyuck Shim; J Simon C Arthur; Roger J Davis; Matthias Gaestel; Gary L Johnson; Sankar Ghosh; Philip Cohen
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.
The Biochemical journal 2008;409(3):711-22.
2008: Matthias Gaestel
Specificity of signaling from MAPKs to MAPKAPKs: kinases' tango nuevo.
Frontiers in bioscience : a journal and virtual library 2008;13():6050-9.
2008: Natalia Ronkina; Alexey Kotlyarov; Matthias Gaestel
MK2 and MK3--a pair of isoenzymes?
Frontiers in bioscience : a journal and virtual library 2008;13():5511-21.
2007: Jagavelu Kumaravelu; Uwe J F Tietge; Matthias Gaestel; Helmut Drexler; Bernhard Schieffer; Udo Bavendiek
Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice.
Circulation research 2007;101(11):1104-12.
2007: Rossana Zaru; Natalia Ronkina; Matthias Gaestel; J Simon C Arthur; Colin Watts
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways.
Nature immunology 2007;8(11):1227-35.
2007: Tiegang Liu; Rod R Warburton; Oscar E Guevara; Nicholas S Hill; Barry L Fanburg; Matthias Gaestel; Usamah S Kayyali
Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2007;37(5):507-17.
2007: Magdalena M Gorska; Qiaoling Liang; Susan J Stafford; Nicolas Goplen; Nilesh Dharajiya; Lei Guo; Sanjiv Sur; Matthias Gaestel; Rafeul Alam
MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation.
The Journal of experimental medicine 2007;204(7):1637-52.
2007: Thusanth Thuraisingam; Yong Zhong Xu; Jacques Moisan; Claude Lachance; James Garnon; Sergio Di Marco; Matthias Gaestel; Danuta Radzioch
Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands.
Molecular immunology 2007;44(14):3482-91.
2007: Yue Wu; Lijun Zhan; Youxi Ai; Michael O Hannigan; Matthias Gaestel; Chi-Kuang Huang; Joseph A Madri
MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization.
Biochemical and biophysical research communications 2007;358(1):170-5.
2007: Anne Marie Sousa; Tiegang Liu; Oscar Guevara; Joanne Stevens; Barry L Fanburg; Matthias Gaestel; Deniz Toksoz; Usamah S Kayyali
Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2.
Journal of cellular biochemistry 2007;100(6):1581-92.
2007: Christian Ehlting; Wi S Lai; Fred Schaper; Erwin D Brenndörfer; Raphaela-Jessica Matthes; Peter C Heinrich; Stephan Ludwig; Perry Blackshear; Matthias Gaestel; Dieter Häussinger; Johannes Bode
Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2813-26.
2007: Astrid Jakobs; Jesko Koehnke; Fabian Himstedt; Martin Funk; Bernhard Korn; Matthias Gaestel; Rainer Niedenthal
Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation.
Nature methods 2007;4(3):245-50.
2007: Astrid Jakobs; Fabian Himstedt; Martin Funk; Bernhard Korn; Matthias Gaestel; Rainer Niedenthal
Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.
Nucleic acids research 2007;35(17):e109.
2007: Natalia Ronkina; Alexey Kotlyarov; Oliver Dittrich-Breiholz; Michael Kracht; Edward Hitti; K Milarski; R Askew; S Marusic; Lih-Ling Lin; Matthias Gaestel; Jean-Baptiste Telliez
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.
Molecular and cellular biology 2007;27(1):170-81.
2006: Shashi Kant; Stefanie Schumacher; Manvendra Singh; Andreas Kispert; Alexey Kotlyarov; Matthias Gaestel
Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5.
The Journal of biological chemistry 2006;281(46):35511-9.
2006: Simon Rousseau; Ignacio Dolado; Victoria A Beardmore; Natalia Shpiro; Rodolfo Marquez; Angel R Nebreda; J Simon C Arthur; Lauren M Case; Marc Tessier-Lavigne; Matthias Gaestel; Ana Cuenda; Philip Cohen
CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway.
Cellular signalling 2006;18(11):1897-905.
2006: Anastassiia Vertii; Cosima Hakim; Alexey Kotlyarov; Matthias Gaestel
Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress.
The Journal of biological chemistry 2006;281(37):26966-75.
2006: Ainsley A Culbert; Stephen Skaper; David R Howlett; Nicholas A Evans; Laura Facci; Peter E Soden; Zoe M Seymour; Florence Guillot; Matthias Gaestel; Jill C Richardson
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.
The Journal of biological chemistry 2006;281(33):23658-67.
2006: Mohamed Bellahcene; Sebastien Jacquet; Xue B Cao; Masaya Tanno; Robert S Haworth; Joanne Layland; Alamgir M N Kabir; Matthias Gaestel; Roger J Davis; Richard A Flavell; Ajay M Shah; Metin Avkiran; Michael S Marber
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor.
Journal of the American College of Cardiology 2006;48(3):545-55.
2006: Martin Hegen; Matthias Gaestel; Cheryl Nickerson-Nutter; Lih-Ling Lin; Jean-Baptiste Telliez
MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1913-7.
2006: Anne Barbara Tietz; Antje Malo; Joachim Diebold; Alexey Kotlyarov; Andreas Herbst; Frank T Kolligs; Barbara Brandt-Nedelev; Walter Halangk; Matthias Gaestel; Burkhard Göke; Claus Schäfer
Gene deletion of MK2 inhibits TNF-alpha and IL-6 and protects against cerulein-induced pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(6):G1298-306.
2006: Jacques Moisan; Pierre Camateros; Thusanth Thuraisingam; Dominique Marion; H Koohsari; Patricia Martin; Marie-Linda Boghdady; Aihao Ding; Matthias Gaestel; Marie-Christine Guiot; James G Martin; Danuta Radzioch
TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway.
American journal of physiology. Lung cellular and molecular physiology 2006;290(5):L987-95.
2006: Edward Hitti; Tatiana Iakovleva; Matthew Brook; Stefanie Deppenmeier; Achim D Gruber; Danuta Radzioch; Andrew R Clark; Perry Blackshear; Alexey Kotlyarov; Matthias Gaestel
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.
Molecular and cellular biology 2006;26(6):2399-407.
2006: Matthias Gaestel
MAPKAP kinases - MKs - two's company, three's a crowd.
Nature reviews. Molecular cell biology 2006;7(2):120-30.
2006: XiaoZhe Wang; Md Abdul Khaleque; Mei Juan Zhao; Rong Zhong; Matthias Gaestel; Stuart K Calderwood
Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.
The Journal of biological chemistry 2006;281(2):782-91.
2006: Matthias Gaestel
Molecular chaperones in signal transduction.
Handbook of experimental pharmacology 2006;(172):93-109.
2005: Steven S An; Corin M Pennella; Achuta Gonnabathula; Jianxin Chen; Ning Wang; Matthias Gaestel; Paul M Hassoun; Jeffrey J Fredberg; Usamah S Kayyali
Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways.
American journal of physiology. Cell physiology 2005;289(3):C521-30.
2005: Yongzhong Li; Sandeep Batra; Antonella Sassano; Beata Majchrzak; David E Levy; Matthias Gaestel; Eleanor N Fish; Roger J Davis; Leonidas C Platanias
Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons.
The Journal of biological chemistry 2005;280(11):10001-10.
2005: H Oliver Weber; Robert L Ludwig; Deborah Morrison; Alexey Kotlyarov; Matthias Gaestel; Karen H Vousden
HDM2 phosphorylation by MAPKAP kinase 2.
Oncogene 2005;24(12):1965-72.
2004: Stefanie Schumacher; Kathrin Laass; Shashi Kant; Yu Shi; Axel Visel; Achim D Gruber; Alexey Kotlyarov; Matthias Gaestel
Scaffolding by ERK3 regulates MK5 in development.
The EMBO journal 2004;23(24):4770-9.
2004: Steven S An; Ben Fabry; Matthew Mellema; Predrag Bursac; William T Gerthoffer; Usamah S Kayyali; Matthias Gaestel; Stephanie A Shore; Jeffrey J Fredberg
Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(5):1701-13.
2004: Yvonne M Yannoni; Matthias Gaestel; Lih-Ling Lin
P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.
FEBS letters 2004;564(1-2):205-11.
2004: Yue Wu; Michael O Hannigan; Alexey Kotlyarov; Matthias Gaestel; Dianqing Wu; Chi-Kuang Huang
A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis.
Biochemical and biophysical research communications 2004;316(3):666-72.
2004: Birgit Sawitzki; Brit Kieselbach; Marion Fisser; Christian Meisel; Katrin Vogt; Matthias Gaestel; Manfred Lehmann; Kirsten Risch; Gerald Grütz; Hans-Dieter Volk
IFN-gamma regulation in anti-CD4 antibody-induced T cell unresponsiveness.
Journal of the American Society of Nephrology : JASN 2004;15(3):695-703.
2004: Yongzhong Li; Antonella Sassano; Beata Majchrzak; Dilip K Deb; David E Levy; Matthias Gaestel; Angel R Nebreda; Eleanor N Fish; Leonidas C Platanias
Role of p38alpha Map kinase in Type I interferon signaling.
The Journal of biological chemistry 2004;279(2):970-9.
2003: Yu Shi; Alexey Kotlyarov; Kathrin Laabeta; Achim D Gruber; Elke Butt; Katrin Marcus; Helmut E Meyer; Anke Friedrich; Hans-Dieter Volk; Matthias Gaestel
Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.
Molecular and cellular biology 2003;23(21):7732-41.
2003: Thusnelda Stromer; Monika Ehrnsperger; Matthias Gaestel; Johannes Buchner
Analysis of the interaction of small heat shock proteins with unfolding proteins.
The Journal of biological chemistry 2003;278(20):18015-21.
2003: Frank Bollig; Reinhard Winzen; Matthias Gaestel; Susanne Kostka; Klaus Resch; Helmut Holtmann
Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization.
Biochemical and biophysical research communications 2003;301(3):665-70.
2002: Dimitris L Kontoyiannis; George Boulougouris; Menelaos Manoloukos; Maria Armaka; Maria Apostolaki; Theresa T Pizarro; Alexey Kotlyarov; Irmgard Forster; Richard Flavell; Matthias Gaestel; Philip Tsichlis; Fabio Cominelli; george kollias
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.
The Journal of experimental medicine 2002;196(12):1563-74.
2002: Simon Rousseau; Nick Morrice; Mark Peggie; David G Campbell; Matthias Gaestel; Philip Cohen
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.
The EMBO journal 2002;21(23):6505-14.
2002: Xinkang Wang; Lin Xu; Hugh Wang; Peter Young; Matthias Gaestel; Giora Z Feuerstein
Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice.
The Journal of biological chemistry 2002;277(46):43968-72.
2002: Usamah S Kayyali; Corin M Pennella; Carolina Trujillo; Otto Villa; Matthias Gaestel; Paul M Hassoun
Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2.
The Journal of biological chemistry 2002;277(45):42596-602.
2002: Alexey Kotlyarov; Matthias Gaestel
Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?
Biochemical Society transactions 2002;30(Pt 6):959-63.
2002: Yu Shi; Matthias Gaestel
In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance.
Biological chemistry 2002;383(10):1519-36.
2002: Alexey Kotlyarov; Yvonne Yannoni; Susann Fritz; Kathrin Laass; Jean-Baptiste Telliez; Deborah Pitman; Lih-Ling Lin; Matthias Gaestel
Distinct cellular functions of MK2.
Molecular and cellular biology 2002;22(13):4827-35.
2002: Martin D Lehner; Frank Schwoebel; Alexey Kotlyarov; Marcel Leist; Matthias Gaestel; Thomas Hartung
Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4667-73.
2002: Armin Neininger; Dimitris L Kontoyiannis; Alexey Kotlyarov; Reinhard Winzen; Rolf Eckert; Hans-Dieter Volk; Helmut Holtmann; george kollias; Matthias Gaestel
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels.
The Journal of biological chemistry 2002;277(5):3065-8.
2002: Claire E Haydon; Peter W Watt; Nick Morrice; Axel Knebel; Matthias Gaestel; Philip Cohen
Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contraction.
Archives of biochemistry and biophysics 2002;397(2):224-31.
2001: Michael O Hannigan; Lijun Zhan; Youxi Ai; Alexey Kotlyarov; Matthias Gaestel; Chi-Kuang Huang
Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3953-61.
2001: Armin Neininger; H Thielemann; Matthias Gaestel
FRET-based detection of different conformations of MK2.
EMBO reports 2001;2(8):703-8.
2001: Dimitris L Kontoyiannis; Alexey Kotlyarov; Ester Carballo; Lena Alexopoulou; Perry Blackshear; Matthias Gaestel; R Davis; R Flavell; george kollias
Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.
The EMBO journal 2001;20(14):3760-70.
2001: Elke Butt; D Immler ; Helmut E Meyer; Alexey Kotlyarov; Kathrin Laass; Matthias Gaestel
Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: phosphorylation-induced actin polymerization caused by HSP27 mutants.
The Journal of biological chemistry 2001;276(10):7108-13.
2000: Monika Ehrnsperger; Matthias Gaestel; Johannes Buchner
Analysis of chaperone properties of small Hsp's.
Methods in molecular biology (Clifton, N.J.) 2000;99():421-9.
1999: Pavel Kovarik; Dagmar Stoiber; P A Eyers; R Menghini; Armin Neininger; Matthias Gaestel; P Cohen; Thomas Decker
Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13956-61.
1999: Reinhard Winzen; Michael Kracht; Birgit Ritter; Arno Wilhelm; C Y Chen; A B Shyu; M Müller; Matthias Gaestel; Klaus Resch; Helmut Holtmann
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.
The EMBO journal 1999;18(18):4969-80.
1999: S Gross; Axel Knebel; T Tenev; Armin Neininger; Matthias Gaestel; Peter Herrlich; Frank-D Böhmer
Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction.
The Journal of biological chemistry 1999;274(37):26378-86.
1999: M Rolli; Alexey Kotlyarov; Kathleen M Sakamoto; Matthias Gaestel; Armin Neininger
Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner.
The Journal of biological chemistry 1999;274(28):19559-64.
1999: T Rogalla; Monika Ehrnsperger; X Preville; Alexey Kotlyarov; Gudrun Lutsch; Cécile Ducasse; C Paul; M Wieske; André-Patrick Arrigo; Johannes Buchner; Matthias Gaestel
Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.
The Journal of biological chemistry 1999;274(27):18947-56.
1999: Monika Ehrnsperger; H Lilie; Matthias Gaestel; Johannes Buchner
The dynamics of Hsp25 quaternary structure. Structure and function of different oligomeric species.
The Journal of biological chemistry 1999;274(21):14867-74.
1999: Olaf Heidenreich; Armin Neininger; Gerhard Schratt; R Zinck; Michael Anthony Cahill; K Engel; Alexey Kotlyarov; Robert Kraft; Susanne Kostka; Matthias Gaestel; Alfred Nordheim
MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.
The Journal of biological chemistry 1999;274(20):14434-43.
1998: Armin Neininger; Matthias Gaestel
Evidence for a hsp25-specific mechanism involved in transcriptional activation by heat shock.
Experimental cell research 1998;242(1):285-93.
1998: K Engel; Alexey Kotlyarov; Matthias Gaestel
Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation.
The EMBO journal 1998;17(12):3363-71.
1998: Johannes Buchner; Monika Ehrnsperger; Matthias Gaestel; S Walke
Purification and characterization of small heat shock proteins.
Methods in enzymology 1998;290():339-49.
1997: H Schultz; T Rogalla; K Engel; J C Lee; Matthias Gaestel
The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27.
Cell stress & chaperones 1997;2(1):41-9.
1997: Monika Ehrnsperger; S Gräber; Matthias Gaestel; Johannes Buchner
Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.
The EMBO journal 1997;16(2):221-9.
1996: R Gotthardt; Armin Neininger; Matthias Gaestel
The anti-cancer drug cisplatin induces H25 in Ehrlich ascites tumor cells by a mechanism different from transcriptional stimulation influencing predominantly H25 translation.
International journal of cancer. Journal international du cancer 1996;66(6):790-5.
1995: K Engel; H Schultz; F Martin; Alexey Kotlyarov; Kathrin Plath; M Hahn; Udo Heinemann; Matthias Gaestel
Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.
The Journal of biological chemistry 1995;270(45):27213-21.
1995: John A Carver; G Esposito; G Schwedersky; Matthias Gaestel
1H NMR spectroscopy reveals that mouse Hsp25 has a flexible C-terminal extension of 18 amino acids.
FEBS letters 1995;369(2-3):305-10.
1995: K Engel; A Ahlers; M A Brach; F Herrmann; Matthias Gaestel
MAPKAP kinase 2 is activated by heat shock and TNF-alpha: in vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade.
Journal of cellular biochemistry 1995;57(2):321-30.
1994: A Ahlers; Claus Belka; Matthias Gaestel; Norbert Lamping; C Sott; F Herrmann; M A Brach
Interleukin-1-induced intracellular signaling pathways converge in the activation of mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 and the subsequent phosphorylation of the 27-kilodalton heat shock protein in monocytic cells.
Molecular pharmacology 1994;46(6):1077-83.
1994: Paul van den IJssel; P Overkamp; U Knauf; Matthias Gaestel; Wilfried W de Jong
Alpha A-crystallin confers cellular thermoresistance.
FEBS letters 1994;355(1):54-6.
1994: Kathrin Plath; K Engel; G Schwedersky; Matthias Gaestel
Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro.
Biochemical and biophysical research communications 1994;203(2):1188-94.
1994: U Knauf; Ursula Jakob; K Engel; Johannes Buchner; Matthias Gaestel
Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.
The EMBO journal 1994;13(1):54-60.
1993: K Engel; Kathrin Plath; Matthias Gaestel
The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.
FEBS letters 1993;336(1):143-7.
1993: K B Merck; J Horwitz; Monique Mennink; P Overkamp; Matthias Gaestel; Hans Bloemendal; Wilfried W de Jong
Comparison of the homologous carboxy-terminal domain and tail of alpha-crystallin and small heat shock protein.
Molecular biology reports 1993;18(3):209-15.
1993: Matthias Gaestel; R Gotthardt; T Müller
Structure and organisation of a murine gene encoding small heat-shock protein Hsp25.
Gene 1993;128(2):279-83.
1993: Ursula Jakob; Matthias Gaestel; K Engel; Johannes Buchner
Small heat shock proteins are molecular chaperones.
The Journal of biological chemistry 1993;268(3):1517-20.
1993: M Gernold; U Knauf; Matthias Gaestel; J Stahl; Peter-M Kloetzel
Development and tissue-specific distribution of mouse small heat shock protein hsp25.
Developmental genetics 1993;14(2):103-11.
1992: Matthias Gaestel; Rainer Benndorf; K Hayess; E Priemer; K Engel
Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.
The Journal of biological chemistry 1992;267(30):21607-11.
1992: U Knauf; H Bielka; Matthias Gaestel
Over-expression of the small heat-shock protein, hsp25, inhibits growth of Ehrlich ascites tumor cells.
FEBS letters 1992;309(3):297-302.
1991: Joachim Behlke; Gudrun Lutsch; Matthias Gaestel; H Bielka
Supramolecular structure of the recombinant murine small heat shock protein hsp25.
FEBS letters 1991;288(1-2):119-22.
1991: Matthias Gaestel; W Schröder; Rainer Benndorf; C Lippmann; Klaus Buchner; Ferdinand Hucho; V A Erdmann; H Bielka
Identification of the phosphorylation sites of the murine small heat shock protein hsp25.
The Journal of biological chemistry 1991;266(22):14721-4.
1991: K Engel; U Knauf; Matthias Gaestel
Generation of antibodies against human hsp27 and murine hsp25 by immunization with a chimeric small heat shock protein.
Biomedica biochimica acta 1991;50(9):1065-71.
1991: H Böhm; B Gross; Matthias Gaestel; U A Bommer; G Ryffel; H Bielka
The 5'-untranslated region of p23 mRNA from the Ehrlich ascites tumor is involved in translation control of the growth related protein p23.
Biomedica biochimica acta 1991;50(12):1193-203.
1989: B Gross; Matthias Gaestel; H Böhm; H Bielka
cDNA sequence coding for a translationally controlled human tumor protein.
Nucleic acids research 1989;17(20):8367.
1989: H Böhm; Rainer Benndorf; Matthias Gaestel; B Gross; P Nürnberg; R Kraft; A Otto; H Bielka
The growth-related protein P23 of the Ehrlich ascites tumor: translational control, cloning and primary structure.
Biochemistry international 1989;19(2):277-86.
1989: Wolf-Hagen Schunck; Eva Kärgel; B Gross; B Wiedmann; S Mauersberger; K Köpke; U Kiessling; M Strauss; Matthias Gaestel; H G Müller
Molecular cloning and characterization of the primary structure of the alkane hydroxylating cytochrome P-450 from the yeast Candida maltosa.
Biochemical and biophysical research communications 1989;161(2):843-50.
1989: Matthias Gaestel; B Gross; Rainer Benndorf; M Strauss; W H Schunk; R Kraft; A Otto; H Böhm; J Stahl; H Drabsch
Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins.
European journal of biochemistry / FEBS 1989;179(1):209-13.
1989: F Noll; W Handschack; E Eichmann; Matthias Gaestel; F Schneider; R Kuhl; Klemens Löster
Production and characterization of four monoclonal antibodies specific for human interferon-alpha-1 and -alpha-2.
Biomedica biochimica acta 1989;48(1):165-76.
1987: L Karawajew; Burkhard Micheel; Olaf Behrsing; Matthias Gaestel
Bispecific antibody-producing hybrid hybridomas selected by a fluorescence activated cell sorter.
Journal of immunological methods 1987;96(2):265-70.
1987: L Karawajew; Burkhard Micheel; Olaf Behrsing; Matthias Gaestel; G Pasternak
Use of fluorescence-activated cell sorting to select hybrid hybridomas producing bispecific monoclonal antibodies.
Haematology and blood transfusion 1987;31():367-8.