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Miguel Aon

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Chaoqin Xie; Miguel A Aon; Nora Biary; Justin Kauffman; Nazareno Paolocci; Carlo G Tocchetti; Fadi G Akar
Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs.
Jackelyn M Kembro; Brian O'Rourke; Raimond L Winslow; Miguel A Aon; Sonia Cortassa
Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model.
Miguel A Aon
Mitochondrial dysfunction, alternans, and arrhythmias.

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All Publications

2013: Chaoqin Xie; Miguel A Aon; Nora Biary; Justin Kauffman; Nazareno Paolocci; Carlo G Tocchetti; Fadi G Akar
Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs.
American journal of physiology. Heart and circulatory physiology 2013;304(7):H916-26.
2013: Jackelyn M Kembro; Brian O'Rourke; Raimond L Winslow; Miguel A Aon; Sonia Cortassa
Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model.
Biophysical journal 2013;104(2):332-43.
2013: Miguel A Aon
Mitochondrial dysfunction, alternans, and arrhythmias.
Frontiers in physiology 2013;4():83.
2012: Mazen Kurdi; Nazareno Paolocci; Vidhya Sivakumaran; Miguel A Aon; Roy J. Duhe; George W Booz
Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes.
The international journal of biochemistry & cell biology 2012;44(12):2106-15.
2012: Carlo G Tocchetti; WALTER WATSON; Chaoqin Xie; Fadi G Akar; Viviane Caceres; Sonia Cortassa; Brian O'Rourke; Nazareno Paolocci; Sa Shi; Regina C Spadari-Bratfisch; Brian A Stanley; Miguel A Aon
GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.
Diabetes 2012;61(12):3094-105.
2012: Miguel A Aon; Sonia Cortassa
Mitochondrial network energetics in the heart.
Wiley interdisciplinary reviews. Systems biology and medicine 2012;4(6):599-613.
2012: Miguel A Aon; Jackelyn Melissa Kembro; Brian O'Rourke; Nazareno Paolocci; Vidhya Sivakumaran; Brian Alan Stanley; Sonia Cortassa
Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: an experimental-computational study.
The Journal of general physiology 2012;139(6):479-91.
2012: Kalesh Sasidharan; Masaru Tomita; Miguel A Aon; David Lloyd; Douglas B Murray
Time-structure of the yeast metabolism in vivo.
Advances in experimental medicine and biology 2012;736():359-79.
2012: David Lloyd; Brian O'Rourke; Sonia Cortassa; Miguel A Aon
What yeast and cardiomyocytes share: ultradian oscillatory redox mechanisms of cellular coherence and survival.
Integrative biology : quantitative biosciences from nano to macro 2012;4(1):65-74.
2012: Sonia Cortassa; Miguel A Aon
Computational modeling of mitochondrial function.
Methods in molecular biology (Clifton, N.J.) 2012;810():311-26.
2011: Lufang Zhou; Miguel A Aon; Ting Liu; Brian O'Rourke
Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.
Journal of molecular and cellular cardiology 2011;51(5):632-9.
2011: Ying-bei Chen; Wen-Chih Cheng; Margaret Dayhoff-Brannigan; Kambiz Nassirpour Alavian; Miguel A Aon; Yi-Te Hsu; Elizabeth A Jonas; Leonard K Kaczmarek; Young H Ko; Hongmei Li; J Michael McCaffery; Brian O'Rourke; Peter L Pedersen; Fernando Pineda; Bing Qi; Lucian Soane; Xinchen Teng; Shifa Zou; J Marie Hardwick
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.
The Journal of cell biology 2011;195(2):263-76.
2011: Brian A Stanley; WALTER WATSON; Sa Shi; Vidhya Sivakumaran; Miguel A Aon; David Lloyd; Iain McDonald; Nazareno Paolocci
Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria.
The Journal of biological chemistry 2011;286(38):33669-77.
2011: An-Chi Wei; Raimond L Winslow; Miguel A Aon; Brian O'Rourke; Sonia Cortassa
Mitochondrial energetics, pH regulation, and ion dynamics: a computational-experimental approach.
Biophysical journal 2011;100(12):2894-903.
2011: Andrew S Midzak; Haolin Chen; Miguel A Aon; Vassilios Papadopoulos; Barry R Zirkin
ATP synthesis, mitochondrial function, and steroid biosynthesis in rodent primary and tumor Leydig cells.
Biology of reproduction 2011;84(5):976-85.
2011: Sonia Cortassa; Brian O'Rourke; Miguel A Aon; Raimond L Winslow
Metabolic control analysis applied to mitochondrial networks.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2011;2011():4673-6.
2010: Felix T Kurz; Miguel A Aon; Brian O'Rourke; Antonis A Armoundas
Wavelet analysis reveals heterogeneous time-dependent oscillations of individual mitochondria.
American journal of physiology. Heart and circulatory physiology 2010;299(5):H1736-40.
2010: Alexander R Lyon; Paul J Joudrey; Dongzhu Jin; Robert D Nass; Miguel A Aon; Brian O'Rourke; Fadi G Akar
Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart.
Journal of molecular and cellular cardiology 2010;49(4):565-75.
2010: Felix T Kurz; Miguel A Aon; Brian O'Rourke; Antonis A Armoundas
Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14315-20.
2010: Miguel A Aon; Sonia Cortassa; Brian O'Rourke
Redox-optimized ROS balance: a unifying hypothesis.
Biochimica et biophysica acta 2010;1797(6-7):865-77.
2010: David A Brown; Miguel A Aon; Chad R Frasier; Ruben C Sloan; Andrew H Maloney; Ethan J Anderson; Brian O'Rourke
Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.
Journal of molecular and cellular cardiology 2010;48(4):673-9.
2010: Miguel A Aon
From isolated to networked: a paradigmatic shift in mitochondrial physiology.
Frontiers in physiology 2010;1():20.
2010: Lufang Zhou; Miguel A Aon; Tabish Almas; Sonia Cortassa; Raimond L Winslow; Brian O'Rourke
A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.
PLoS computational biology 2010;6(1):e1000657.
2010: Miguel A Aon; Sonia Cortassa; An-Chi Wei; Morten Grunnet; Brian O'Rourke
Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria.
Biochimica et biophysica acta 2010;1797(1):71-80.
2009: Lufang Zhou; Sonia Cortassa; An-Chi Wei; Miguel A Aon; Raimond L Winslow; Brian O'Rourke
Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes.
Biophysical journal 2009;97(7):1843-52.
2009: Miguel A Aon; Sonia Cortassa; Fadi G Akar; David A Brown; L Zhou; Brian O'Rourke
From mitochondrial dynamics to arrhythmias.
The international journal of biochemistry & cell biology 2009;41(10):1940-8.
2009: Sonia Cortassa; Brian O'Rourke; Raimond L Winslow; Miguel A Aon
Control and regulation of integrated mitochondrial function in metabolic and transport networks.
International journal of molecular sciences 2009;10(4):1500-13.
2009: Sonia Cortassa; Brian O'Rourke; Raimond L Winslow; Miguel A Aon
Control and regulation of mitochondrial energetics in an integrated model of cardiomyocyte function.
Biophysical journal 2009;96(6):2466-78.
2008: MARTIN SLODZINSKI; Miguel A Aon; Brian O'Rourke
Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact hearts.
Journal of molecular and cellular cardiology 2008;45(5):650-60.
2008: David A Brown; Miguel A Aon; Fadi G Akar; Ting Liu; Nicolas Sorarrain; Brian O'Rourke
Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.
Cardiovascular research 2008;79(1):141-9.
2008: Miguel A Aon; Marc R Roussel; Sonia Cortassa; Brian O'Rourke; Douglas B Murray; Manfred Beckmann; David Lloyd
The scale-free dynamics of eukaryotic cells.
PloS one 2008;3(11):e3624.
2008: Miguel A Aon; Sonia Cortassa; Brian O'Rourke
Mitochondrial oscillations in physiology and pathophysiology.
Advances in experimental medicine and biology 2008;641():98-117.
2007: Katey M Lemar; Miguel A Aon; Sonia Cortassa; Brian O'Rourke; Carsten T Müller; David Lloyd
Diallyl disulphide depletes glutathione in Candida albicans: oxidative stress-mediated cell death studied by two-photon microscopy.
Yeast (Chichester, England) 2007;24(8):695-706.
2007: Miguel A Aon; Sonia Cortassa; Christoph Maack; Brian O'Rourke
Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.
The Journal of biological chemistry 2007;282(30):21889-900.
2007: Miguel A Aon; Sonia Cortassa; Katey M Lemar; Anthony J Hayes; David Lloyd
Single and cell population respiratory oscillations in yeast: a 2-photon scanning laser microscopy study.
FEBS letters 2007;581(1):8-14.
2007: Carlo G Tocchetti; Wang Wang; Jeffrey P Froehlich; Sabine Huke; Miguel A Aon; Gerald M Wilson; Giulietta Di Benedetto; Brian O'Rourke; Wei Dong Gao; David A Wink; John P Toscano; Manuela Zaccolo; Donald M Bers; Hector H Valdivia; Heping Cheng; David A Kass; Nazareno Paolocci
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
Circulation research 2007;100(1):96-104.
2007: Brian O'Rourke; Sonia Cortassa; Fadi G Akar; Miguel A Aon
Mitochondrial ion channels in cardiac function and dysfunction.
Novartis Foundation symposium 2007;287():140-51; discussion 152-6.
2006: Kevin G Soucy; Sungwoo Ryoo; Alexandre Benjo; Hyun Kyo Lim; Gaurav Gupta; Jayson S Sohi; Jeremy Elser; Miguel A Aon; Daniel Nyhan; Artin A Shoukas; Dan E Berkowitz
Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;101(6):1751-9.
2006: Miguel A Aon; Sonia Cortassa; Brian O'Rourke
The fundamental organization of cardiac mitochondria as a network of coupled oscillators.
Biophysical journal 2006;91(11):4317-27.
2006: Sonia Cortassa; Miguel A Aon; Brian O'Rourke; Robert Jacques; Hsiang-Jer Tseng; Eduardo Marban; Raimond L Winslow
A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte.
Biophysical journal 2006;91(4):1564-89.
2006: Christoph Maack; Sonia Cortassa; Miguel A Aon; Anand Ganesan; Ting Liu; Brian O'Rourke
Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes.
Circulation research 2006;99(2):172-82.
2006: Miguel A Aon; Sonia Cortassa; Fadi G Akar; Brian O'Rourke
Mitochondrial criticality: a new concept at the turning point of life or death.
Biochimica et biophysica acta 2006;1762(2):232-40.
2005: Fadi G Akar; Miguel A Aon; Gordon F Tomaselli; Brian O'Rourke
The mitochondrial origin of postischemic arrhythmias.
The Journal of clinical investigation 2005;115(12):3527-35.
2005: Katey M Lemar; Ourania Passa; Miguel A Aon; Sonia Cortassa; Carsten T Müller; Sue Plummer; Brian O'Rourke; David Lloyd
Allyl alcohol and garlic (Allium sativum) extract produce oxidative stress in Candida albicans.
Microbiology (Reading, England) 2005;151(Pt 10):3257-65.
2005: Brian O'Rourke; Sonia Cortassa; Miguel A Aon
Mitochondrial ion channels: gatekeepers of life and death.
Physiology (Bethesda, Md.) 2005;20():303-15.
2005: ROSELLE ABRAHAM; Charles A Henrikson; Leslie Tung; Marvin G Chang; Miguel A Aon; Tian Xue; Ronald A Li; Brian O' Rourke; Eduardo Marban
Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation.
Circulation research 2005;97(2):159-67.
2004: Sonia Cortassa; Miguel A Aon; Raimond L Winslow; Brian O'Rourke
A mitochondrial oscillator dependent on reactive oxygen species.
Biophysical journal 2004;87(3):2060-73.
2004: Miguel A Aon; Sonia Cortassa; Brian O'Rourke
Percolation and criticality in a mitochondrial network.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4447-52.
2004: Miguel A Aon; Brian O'Rourke; Sonia Cortassa
The fractal architecture of cytoplasmic organization: scaling, kinetics and emergence in metabolic networks.
Molecular and cellular biochemistry 2004;256-257(1-2):169-84.
2003: Miguel A Aon; Sonia Cortassa; Eduardo Marban; Brian O'Rourke
Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes.
The Journal of biological chemistry 2003;278(45):44735-44.
2003: Diego F Gómez-Casati; Sonia Cortassa; Miguel A Aon; Alberto A Iglesias
Ultrasensitive behavior in the synthesis of storage polysaccharides in cyanobacteria.
Planta 2003;216(6):969-75.
2003: Sonia Cortassa; Miguel A Aon; Eduardo Marban; Raimond L Winslow; Brian O'Rourke
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics.
Biophysical journal 2003;84(4):2734-55.
2002: Miguel A Aon; Sonia Cortassa
Coherent and robust modulation of a metabolic network by cytoskeletal organization and dynamics.
Biophysical chemistry 2002;97(2-3):213-31.
2001: M L Gaspar; M N Cabello; Ricardo J Pollero; Miguel A Aon
Fluorescein diacetate hydrolysis as a measure of fungal biomass in soil.
Current microbiology 2001;42(5):339-44.
2001: D Lloyd; Miguel A Aon; Sonia Cortassa
Why homeodynamics, not homeostasis?
TheScientificWorldJournal 2001;1():133-45.
2001: Miguel A Aon; Diego F Gomez-Casati; Alberto A Iglesias; Sonia Cortassa
Ultrasensitivity in (supra)molecularly organized and crowded environments.
Cell biology international 2001;25(11):1091-9.
2001: Diego F Gómez-Casati; Miguel A Aon; Sonia Cortassa; Alberto A Iglesias
Measurement of the glycogen synthetic pathway in permeabilized cells of cyanobacteria.
FEMS microbiology letters 2001;194(1):7-11.
2000: D F Casati; Miguel A Aon; Alberto A Iglesias
Kinetic and structural analysis of the ultrasensitive behaviour of cyanobacterial ADP-glucose pyrophosphorylase.
The Biochemical journal 2000;350 Pt 1():139-47.
2000: Miguel A Aon; Sonia Cortassa; D Lloyd
Chaotic dynamics and fractal space in biochemistry: simplicity underlies complexity.
Cell biology international 2000;24(8):581-7.
2000: Sonia Cortassa; JC Aon; Miguel A Aon; J F T Spencer
Dynamics of metabolism and its interactions with gene expression during sporulation in Saccharomyces cerevisiae.
Advances in microbial physiology 2000;43():75-115.
1999: DANIEL ALONSO; Hernán G Farina; C Arregui; Miguel A Aon; daniel gomez
Modulation of urokinase-type plasminogen activator and metalloproteinase activities in cultured mouse mammary-carcinoma cells: enhancement by paclitaxel and inhibition by nocodazole.
International journal of cancer. Journal international du cancer 1999;83(2):242-6.
1999: Miguel A Aon; Alberto A Iglesias
Ultrasensitive glycogen synthesis in Cyanobacteria.
FEBS letters 1999;446(1):117-21.
1999: Miguel A Aon; Sonia Cortassa
Quantitation of the effects of disruption of catabolite (de)repression genes on the cell cycle behavior of Saccharomyces cerevisiae.
Current microbiology 1999;38(1):57-60.
1998: Miguel A Aon; Sonia Cortassa
Catabolite repression mutants of Saccharomyces cerevisiae show altered fermentative metabolism as well as cell cycle behavior in glucose-limited chemostat cultures.
Biotechnology and bioengineering 1998;59(2):203-13.
1997: JC Aon; Miguel A Aon; J F T Spencer; Sonia Cortassa
Modulation of sporulation and metabolic fluxes in Saccharomyces cerevisiae by 2 deoxy glucose.
Antonie van Leeuwenhoek 1997;72(4):283-90.
1996: Miguel A Aon; A Cáceres; Sonia Cortassa
Heterogeneous distribution and organization of cytoskeletal proteins drive differential modulation of metabolic fluxes.
Journal of cellular biochemistry 1996;60(2):271-8.
1995: H D Genta; M E Mónaco; Miguel A Aon
Decreased mitochondrial biogenesis in temperature-sensitive cell division cycle mutants of Saccharomyces cerevisiae.
Current microbiology 1995;31(6):327-31.
1995: Sonia Cortassa; JC Aon; Miguel A Aon
Fluxes of carbon, phosphorylation, and redox intermediates during growth of saccharomyces cerevisiae on different carbon sources.
Biotechnology and bioengineering 1995;47(2):193-208.
1995: M E Mónaco; P A Valdecantos; Miguel A Aon
Carbon and energy uncoupling associated with cell cycle arrest of cdc mutants of Saccharomyces cerevisiae may be linked to glucose-induced catabolite repression.
Experimental cell research 1995;217(1):52-6.
1995: Miguel A Aon; M E Mónaco; Sonia Cortassa
Carbon and energetic uncoupling are associated with block of division at different stages of the cell cycle in several cdc mutants of Saccharomyces cerevisiae.
Experimental cell research 1995;217(1):42-51.
1995: Miguel A Aon; Sonia Cortassa
Cell growth and differentiation from the perspective of dynamical organization of cellular and subcellular processes.
Progress in biophysics and molecular biology 1995;64(1):55-79.
1994: Sonia Cortassa; Miguel A Aon
Spatio-temporal regulation of glycolysis and oxidative phosphorylation in vivo in tumor and yeast cells.
Cell biology international 1994;18(7):687-713.
1994: Miguel A Aon; Sonia Cortassa
On the fractal nature of cytoplasm.
FEBS letters 1994;344(1):1-4.
1994: Sonia Cortassa; A Cáceres; Miguel A Aon
Microtubular protein in its polymerized or nonpolymerized states differentially modulates in vitro and intracellular fluxes catalyzed by enzymes of carbon metabolism.
Journal of cellular biochemistry 1994;55(1):120-32.
1993: Sonia Cortassa; Miguel A Aon
Altered topoisomerase activities may be involved in the regulation of DNA supercoiling in aerobic-anaerobic transitions in Escherichia coli.
Molecular and cellular biochemistry 1993;126(2):115-24.
1993: Miguel A Aon; Sonia Cortassa
An allometric interpretation of the spatio-temporal organization of molecular and cellular processes.
Molecular and cellular biochemistry 1993;120(1):1-13.
1992: N Verdoni; Miguel A Aon; Jean-Michel Lebeault
Metabolic and energetic control of Pseudomonas mendocina growth during transitions from aerobic to oxygen-limited conditions in chemostat cultures.
Applied and environmental microbiology 1992;58(9):3150-6.
1992: C Rabouille; Sonia Cortassa; Miguel A Aon
Fractal organisation in biological macromolecular lattices.
Journal of biomolecular structure & dynamics 1992;9(5):1013-24.
1991: Sonia Cortassa; Miguel A Aon; Hans V Westerhoff
Linear nonequilibrium thermodynamics describes the dynamics of an autocatalytic system.
Biophysical journal 1991;60(4):794-803.
1991: Miguel A Aon; Sonia Cortassa; Hans V Westerhoff; J A Berden; E Van Spronsen; Karel van Dam
Dynamic regulation of yeast glycolytic oscillations by mitochondrial functions.
Journal of cell science 1991;99 ( Pt 2)():325-34.
1991: Miguel A Aon; Sonia Cortassa
Thermodynamic evaluation of energy metabolism in mixed substrate catabolism: modeling studies of stationary and oscillatory states.
Biotechnology and bioengineering 1991;37(3):197-204.
1990: N Verdoni; Miguel A Aon; Jean-Michel Lebeault; Daniel Thomas
Proton motive force, energy recycling by end product excretion, and metabolic uncoupling during anaerobic growth of Pseudomonas mendocina.
Journal of bacteriology 1990;172(12):6673-81.
1990: C Rabouille; Miguel A Aon; G Muller; J Cartaud; Daniel Thomas
The supramolecular organization of ovomucin. Biophysical and morphological studies.
The Biochemical journal 1990;266(3):697-706.
1989: Miguel A Aon; Sonia Cortassa; J F Hervagault; Daniel Thomas
pH-induced bistable dynamic behaviour in the reaction catalysed by glucose-6-phosphate dehydrogenase and conformational hysteresis of the enzyme.
The Biochemical journal 1989;262(3):795-800.
1989: C Rabouille; Miguel A Aon; Daniel Thomas
Interactions involved in ovomucin gel-forming properties: a rheological-biochemical approach.
Archives of biochemistry and biophysics 1989;270(2):495-503.
1989: Miguel A Aon; D Thomas; J F Hervagault
Spatial patterns in a photobiochemical system.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):516-9.
1985: Miguel A Aon; J A Curtino
Protein-bound glycogen is linked to tyrosine residues.
The Biochemical journal 1985;229(1):269-72.
1984: Miguel A Aon; J A Curtino
Evidence for the glycoprotein nature of retina glycogen.
European journal of biochemistry / FEBS 1984;140(3):557-66.