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Christian Gaiddon

Research Profile

Living Beings

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Publications

TOP 3
Bastien Boff; Christian Gaiddon; Michel Pfeffer
Cancer cell cytotoxicity of cyclometalated compounds obtained with osmium(II) complexes.
Vania Vidimar; Ludivine Fetzer; S Harlepp; Pascal Hébraud; Marcelina Klajner; Cynthia Licona; Jean-Philippe Loeffler; Georg Mellitzer; Xiangjun Meng; Michel Pfeffer; Gianni Sava; Marjorie Sidhoum; Claude Sirlin; Christian Gaiddon
Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity.
Nigel Ribeiro; Frédéric Thuaud; Yohann Bernard; Thierry CRESTEIL; Christian Gaiddon; Audrey Hild; Etienne C Hirsch; Patrick Pierre Michel; Canan G Nebigil; Laurent Désaubry
Flavaglines as potent anticancer and cytoprotective agents.

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All Publications

2013: Bastien Boff; Christian Gaiddon; Michel Pfeffer
Cancer cell cytotoxicity of cyclometalated compounds obtained with osmium(II) complexes.
Inorganic chemistry 2013;52(5):2705-15.
2012: Vania Vidimar; Ludivine Fetzer; S Harlepp; Pascal Hébraud; Marcelina Klajner; Cynthia Licona; Jean-Philippe Loeffler; Georg Mellitzer; Xiangjun Meng; Michel Pfeffer; Gianni Sava; Marjorie Sidhoum; Claude Sirlin; Christian Gaiddon
Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity.
Biochemical pharmacology 2012;84(11):1428-36.
2012: Nigel Ribeiro; Frédéric Thuaud; Yohann Bernard; Thierry CRESTEIL; Christian Gaiddon; Audrey Hild; Etienne C Hirsch; Patrick Pierre Michel; Canan G Nebigil; Laurent Désaubry
Flavaglines as potent anticancer and cytoprotective agents.
Journal of medicinal chemistry 2012;55(22):10064-73.
2011: Ludivine Fetzer; Christian Gaiddon; Moussa Ali; Bastien Boff; Jean-Paul Collin; Claude Sirlin; Meng Xiangjun; Michel Pfeffer
Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier.
Dalton transactions (Cambridge, England : 2003) 2011;40(35):8869-78.
2011: Frédéric Thuaud; Thierry CRESTEIL; Christian Gaiddon; Nigel Ribeiro; Laurent Désaubry
Novel flavaglines displaying improved cytotoxicity.
Journal of medicinal chemistry 2011;54(1):411-5.
2010: Marcelina Klajner; Pascal Hebraud; Claude B Sirlin; Christian Gaiddon; S Harlepp
DNA binding to an anticancer organo-ruthenium complex.
The journal of physical chemistry. B 2010;114(44):14041-7.
2009: Xiangjun Meng; Mili L Leyva; marjorie sidhoum; Isabelle Gross; Samir Benosman; Bastien Fricker; Sébastien Harlepp; Pascal Hébraud; Anne Boos; Pauline Wlosik; Pierre Bischoff; Claude Sirlin; Michel Pfeffer; Jean-Philippe Loeffler; Christian Gaiddon
A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP.
Cancer research 2009;69(13):5458-66.
2009: Chihiro Ohtsubo; Daisuke Shiokawa; Masami Kodama; Christian Gaiddon; Hitoshi Nakagama; Aart G Jochemsen; Yoichi Taya; Koji Okamoto
Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.
Cancer science 2009;100(7):1291-9.
2007: S Benosman; Isabelle Gross; N Clarke; A G Jochemsen; K Okamoto; Jean-Philippe Loeffler; Christian Gaiddon
Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis.
Cell death and differentiation 2007;14(12):2047-57.
2007: Isabelle Gross; O Armant; S Benosman; J L G de Aguilar; Jean-Noel Freund; Michèle Kedinger; Jonathan D Licht; Christian Gaiddon; Jean-Philippe Loeffler
Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.
Cell death and differentiation 2007;14(10):1802-12.
2007: Maria Lokshin; Yingchun Li; Christian Gaiddon; Carol Prives
p53 and p73 display common and distinct requirements for sequence specific binding to DNA.
Nucleic acids research 2007;35(1):340-52.
2005: Christian Gaiddon; P Jeannequin; Pierre Bischoff; M Pfeffer; C Sirlin; Jean-Philippe Loeffler
Ruthenium (II)-derived organometallic compounds induce cytostatic and cytotoxic effects on mammalian cancer cell lines through p53-dependent and p53-independent mechanisms.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1403-11.
2005: Isabelle Gross; Benoit Lhermitte; Claire Domon-Dell; Isabelle Duluc; Elisabeth Martin; Christian Gaiddon; Michèle Kedinger; Jean-Noel Freund
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.
Oncogene 2005;24(54):7955-63.
2005: Franck di Scala; Luc Dupuis; Christian Gaiddon; Marc de Tapia; Natasa Jokic; Jose-Luis Gonzalez de Aguilar; Jean-Sébastien Raul; Bertrand Ludes; Jean-Philippe Loeffler
Tissue specificity and regulation of the N-terminal diversity of reticulon 3.
The Biochemical journal 2005;385(Pt 1):125-34.
2003: Christian Gaiddon; Maria Lokshin; Isabelle Gross; Danielle Levasseur; Yoichi Taya; Jean-Philippe Loeffler; Carol Prives
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.
The Journal of biological chemistry 2003;278(30):27421-31.
2001: Christian Gaiddon; Maria Lokshin; J Ahn; T Zhang; Carol Prives
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.
Molecular and cellular biology 2001;21(5):1874-87.
2000: Jose-Luis González De Aguilar; JW Gordon; Frédérique René; Marc de Tapia; Bernadette Lutz-Bucher; Christian Gaiddon; Jean-Philippe Loeffler
Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway.
Neurobiology of disease 2000;7(4):406-15.
1999: Christian Gaiddon; N C Moorthy; Carol Prives
Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.
The EMBO journal 1999;18(20):5609-21.
1999: Christian Gaiddon; Yves Larmet; Emmanuelle Trinh; Anne-Laurence Boutillier; B Sommer; Jean-Philippe Loeffler
Brain-derived neurotrophic factor exerts opposing effects on beta2-adrenergic receptor according to depolarization status of cerebellar neurons.
Journal of neurochemistry 1999;73(4):1467-76.
1999: Christian Gaiddon; Marc de Tapia; Jean-Philippe Loeffler
The tissue-specific transcription factor Pit-1/GHF-1 binds to the c-fos serum response element and activates c-fos transcription.
Molecular endocrinology (Baltimore, Md.) 1999;13(5):742-51.
1999: F Sohm; Christian Gaiddon; M Antoine; Anne-Laurence Boutillier; Jean-Philippe Loeffler
The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity.
Oncogene 1999;18(17):2762-9.
1999: Charles J DiComo; Christian Gaiddon; Carol Prives
p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.
Molecular and cellular biology 1999;19(2):1438-49.
1998: Anne-Laurence Boutillier; Christian Gaiddon; D Lorang; James Roberts; Jean-Philippe Loeffler
Transcriptional activation of the proopiomelanocortin gene by cyclic AMP-responsive element binding protein.
Pituitary 1998;1(1):33-43.
1997: PJ Cabot; L Carter; Christian Gaiddon; Q Zhang; Michael Schäfer; Jean-Philippe Loeffler; Christoph Stein
Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats.
The Journal of clinical investigation 1997;100(1):142-8.
1996: Frédérique René; D Monnier; Christian Gaiddon; JM Félix; Jean-Philippe Loeffler
Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes.
Neuroendocrinology 1996;64(1):2-13.
1996: M Antoine; Christian Gaiddon; Jean-Philippe Loeffler
Ca2+/calmodulin kinase types II and IV regulate c-fos transcription in the AtT20 corticotroph cell line.
Molecular and cellular endocrinology 1996;120(1):1-8.
1996: Christian Gaiddon; Jean-Philippe Loeffler; Yves Larmet
Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons.
Journal of neurochemistry 1996;66(6):2279-86.
1996: Christian Gaiddon; J Tian; Jean-Philippe Loeffler; C Bancroft
Constitutively active G(S) alpha-subunits stimulate Pit-1 promoter activity via a protein kinase A-mediated pathway acting through deoxyribonucleic acid binding sites both for Pit-1 and for adenosine 3',5'-monophosphate response element-binding protein.
Endocrinology 1996;137(4):1286-91.
1995: Christian Gaiddon; L Mercken; C Bancroft; Jean-Philippe Loeffler
Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A.
Endocrinology 1995;136(10):4331-8.
1994: Christian Gaiddon; Anne-Laurence Boutillier; D Monnier; L Mercken; Jean-Philippe Loeffler
Genomic effects of the putative oncogene G alpha s. Chronic transcriptional activation of the c-fos proto-oncogene in endocrine cells.
The Journal of biological chemistry 1994;269(36):22663-71.