FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Michael Gait

Research Profile

Chemicals & Drugs

Concepts & Ideas

Living Beings

HIV-1

Anatomy

Hela Cells

Physiology

Co-author Network

Publications

TOP 3
Michael J Gait; Makoto Komiyama; Jason Micklefield; Nadrian C Seeman; Oliver Seitz; David R Liu
Nucleic acids: new life, new materials.
Thibault Coursindel; Peter Järver; Michael J Gait
Peptide-based in vivo delivery agents for oligonucleotides and siRNA.
Adrian G Torres; Michael J Gait
Exploiting cell surface thiols to enhance cellular uptake.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Michael Gait (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Michael J Gait; Makoto Komiyama; Jason Micklefield; Nadrian C Seeman; Oliver Seitz; David R Liu
Nucleic acids: new life, new materials.
Organic & biomolecular chemistry 2013;11(13):2058-9.
2012: Thibault Coursindel; Peter Järver; Michael J Gait
Peptide-based in vivo delivery agents for oligonucleotides and siRNA.
Nucleic acid therapeutics 2012;22(2):71-6.
2012: Adrian G Torres; Michael J Gait
Exploiting cell surface thiols to enhance cellular uptake.
Trends in biotechnology 2012;30(4):185-90.
2012: Adrian G Torres; Elena Vigorito; Donna Williams; Filip Wojciechowski; Naowras Al-Obaidi; Martin M Fabani; Robert H E Hudson; Oliver Seitz; Michael J Gait
Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs.
Nucleic acids research 2012;40(5):2152-67.
2012: Thomas C Roberts; Samir El Andaloussi; Corinne Betts; K Emelie M Blomberg; Thibault Coursindel; Ci Edvard Smith; Michael J Gait; Caroline Godfrey; Graham McClorey; Matthew Ja Wood
Expression Analysis in Multiple Muscle Groups and Serum Reveals Complexity in the MicroRNA Transcriptome of the mdx Mouse with Implications for Therapy.
Molecular therapy. Nucleic acids 2012;1():e39.
2012: Corinne Betts; Thibault Coursindel; Michael J Gait; Caroline Godfrey; Suzan M Hammond; Amer F Saleh; Andrey A Arzumanov; Matthew Ja Wood
Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment.
Molecular therapy. Nucleic acids 2012;1():e38.
2012: Peter Järver; Matthew Ja Wood; Samir El Andaloussi; Thibault Coursindel; Caroline Godfrey; Michael J Gait
Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA.
Molecular therapy. Nucleic acids 2012;1():e27.
2012: Alberto Malerba; Graham McClorey; Linda Popplewell; Amer F Saleh; Matthew Ja Wood; Michael J Gait; Jagjeet K Kang; George Dickson
Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy.
Molecular therapy. Nucleic acids 2012;1():e62.
2012: Amer F Saleh; Andrey A Arzumanov; Michael J Gait
Overview of alternative oligonucleotide chemistries for exon skipping.
Methods in molecular biology (Clifton, N.J.) 2012;867():365-78.
2011: Adrian G Torres; Richard N Threlfall; Michael J Gait
Potent and sustained cellular inhibition of miR-122 by lysine-derivatized peptide nucleic acids (PNA) and phosphorothioate locked nucleic acid (LNA)/2'-O-methyl (OMe) mixmer anti-miRs in the absence of transfection agents.
Artificial DNA, PNA & XNA 2011;2(3):71-8.
2011: HaiFang Yin; Andrey A Arzumanov; Shirin Ashraf; Corinne Betts; Patrizia Camelliti; Michael J Gait; Suzan Hammond; Thomas Merritt; Amer F Saleh; Yiqi Seow; Matthew Ja Wood
Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(7):1295-303.
2011: Kariem Ezzat; Michael J Gait; Peter Guterstam; Mattias Hällbrink; Suzan M Hammond; Taavi Lehto; Staffan Lindberg; Tarek Magdy; Pedro M D Moreno; Rannar Sillard; C I Edvard Smith; Joana R Viola; Matthew J A Wood; Eman M Zaghloul; Samir El-Andaloussi; Rania Abdo; Andrey A Arzumanov; Ulo Langel
PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation.
Nucleic acids research 2011;39(12):5284-98.
2011: Adrian G Torres; Martin M Fabani; Elena Vigorito; Michael J Gait
MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection.
RNA (New York, N.Y.) 2011;17(5):933-43.
2011: Alastair Crisp; Haifang Yin; Aurelie Goyenvalle; Corinne Betts; Hong M Moulton; Yiqi Seow; Arran Babbs; Thomas Merritt; Amer F Saleh; Michael J Gait; Daniel J Stuckey; Kieran Clarke; Kay E Davies; Matthew J A Wood
Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.
Human molecular genetics 2011;20(3):413-21.
2011: Rachida Abes; Andrey A Arzumanov; Amer F Saleh; Fatouma Said Hassane; Michael J Gait; Bernard Lebleu
Splice redirection as a convenient assay to monitor CPP-ON efficiency and mechanism.
Methods in molecular biology (Clifton, N.J.) 2011;683():307-20.
2010: Amer F Saleh; Andrey A Arzumanov; Rachida Abes; David Owen; Bernard Lebleu; Michael J Gait
Synthesis and splice-redirecting activity of branched, arginine-rich peptide dendrimer conjugates of peptide nucleic acid oligonucleotides.
Bioconjugate chemistry 2010;21(10):1902-11.
2010: Martin M Fabani; Cei Abreu-Goodger; Donna Williams; Paul A Lyons; Adrian G Torres; Kenneth G C Smith; Anton J Enright; Michael J Gait; Elena Vigorito
Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.
Nucleic acids research 2010;38(13):4466-75.
2010: Qingsong Wang; Haifang Yin; Patrizia Camelliti; Corinne Betts; Hong Moulton; Hyunil Lee; Amer F Saleh; Michael J Gait; Matthew J A Wood
In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy.
The journal of gene medicine 2010;12(4):354-64.
2010: Matthew J A Wood; Michael J Gait; Haifang Yin
RNA-targeted splice-correction therapy for neuromuscular disease.
Brain : a journal of neurology 2010;133(Pt 4):957-72.
2010: HaiFang Yin; Corinne Betts; Amer F Saleh; Gabriela D Ivanova; Hyunil Lee; Yiqi Seow; Dalsoo Kim; Michael J Gait; Matthew J A Wood
Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(4):819-27.
2010: F Said Hassane; A F Saleh; R Abes; Michael J Gait; Bernard Lebleu
Cell penetrating peptides: overview and applications to the delivery of oligonucleotides.
Cellular and molecular life sciences : CMLS 2010;67(5):715-26.
2009: Fatouma Said Hassane; Gabriela D Ivanova; Eleonora Bolewska-Pedyczak; Rachida Abes; Andrey A Arzumanov; Michael J Gait; Bernard Lebleu; Jean Gariépy
A peptide-based dendrimer that enhances the splice-redirecting activity of PNA conjugates in cells.
Bioconjugate chemistry 2009;20(8):1523-30.
2009: Anke Detzer; Marita Overhoff; Winfried Wünsche; Maria Rompf; John J Turner; Gabriela D Ivanova; Michael J Gait; Georg Sczakiel
Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide.
RNA (New York, N.Y.) 2009;15(4):627-36.
2008: Gabriela Ivanova; Andrey A Arzumanov; Rachida Abes; Haifang Yin; Matthew J A Wood; Bernard Lebleu; Michael J Gait
Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.
Nucleic acids research 2008;36(20):6418-28.
2008: R Abes; Andrey A Arzumanov; Hong M Moulton; Saïd Abes; Gabriela Ivanova; Michael J Gait; P Iversen; Bernard Lebleu
Arginine-rich cell penetrating peptides: design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(4):455-60.
2008: Bernard Lebleu; Hong M Moulton; Rachida Abes; Gabriela Ivanova; Saïd Abes; David A Stein; Patrick L Iversen; Andrey A Arzumanov; Michael J Gait
Cell penetrating peptide conjugates of steric block oligonucleotides.
Advanced drug delivery reviews 2008;60(4-5):517-29.
2008: Douglas Brown; Emily Joy; Jane S Greatorex; Michael J Gait; Andrew M L Lever
Steric block high affinity oligonucleotide analogues: a new tool for mapping RNA-protein binding sites.
Nucleosides, nucleotides & nucleic acids 2008;27(2):196-212.
2008: Martin M Fabani; Michael J Gait
miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates.
RNA (New York, N.Y.) 2008;14(2):336-46.
2008: Gabriela D Ivanova; Martin M Fabani; Andrey A Arzumanov; Rachida Abes; Haifang Yin; Bernard Lebleu; Matthew Wood; Michael J Gait
PNA-peptide conjugates as intracellular gene control agents.
Nucleic acids symposium series (2004) 2008;(52):31-2.
2007: Sarah Resina; Saïd Abes; John J Turner; Paul Prevot; Adrian Travo; Philippe Clair; Michael J Gait; Alain THIERRY; Bernard Lebleu
Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides.
International journal of pharmaceutics 2007;344(1-2):96-102.
2007: Sterghios A Moschos; Simon W Jones; Mark M Perry; Andrew Williams; Jonas Sten Erjefalt; John J Turner; Peter J Barnes; Brian Stephen Sproat; Michael J Gait; Mark A Lindsay
Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.
Bioconjugate chemistry 2007;18(5):1450-9.
2007: R Abes; Andrey A Arzumanov; Hong M Moulton; Saïd Abes; Gabriela Ivanova; Patrick L Iversen; Michael J Gait; Bernard Lebleu
Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.
Biochemical Society transactions 2007;35(Pt 4):775-9.
2007: Carmelo Di Primo; Ivo Rudloff; Sandrine Reigadas; Andrey A Arzumanov; Michael J Gait; Jean-Jacques Toulmé
Systematic screening of LNA/2'-O-methyl chimeric derivatives of a TAR RNA aptamer.
FEBS letters 2007;581(4):771-4.
2007: Saïd Abes; Hong M Moulton; J Turner; Philippe Clair; Jean Philippe Richard; P Iversen; Michael J Gait; Bernard Lebleu
Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides.
Biochemical Society transactions 2007;35(Pt 1):53-5.
2007: Timofei S Zatsepin; Tatiana S Oretskaya; Michael J Gait; Dmitry A Stetsenko
Preparation of 2'-hydrazino oligonucleotides and their reaction with aldehydes and 1,3-diketones.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):795-8.
2007: Gabriela Ivanova; Andrey A Arzumanov; Michael J Gait; Sandrine Reigadas; Jean-Jacques Toulmé; Marie-Line Andreola; Damian Ittig; Christian J Leumann
Comparative studies of tricyclo-DNA- and LNA-containing oligonucleotides as inhibitors of HIV-1 gene expression.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):747-50.
2007: Saïd Abes; John J Turner; Gabriela Ivanova; David Owen; Donna Williams; Andrey A Arzumanov; Philippe Clair; Michael J Gait; Bernard Lebleu
Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide.
Nucleic acids research 2007;35(13):4495-502.
2007: Gabriela Ivanova; Sandrine Reigadas; Damian Ittig; Andrey A Arzumanov; Marie-Line Andreola; Christian J Leumann; Jean-Jacques Toulmé; Michael J Gait
Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity.
Oligonucleotides 2007;17(1):54-65.
2007: Françoise Debart; Saïd Abes; Gaëlle Deglane; Hong M Moulton; Philippe Clair; Michael J Gait; Jean-Jacques Vasseur; Bernard Lebleu
Chemical modifications to improve the cellular uptake of oligonucleotides.
Current topics in medicinal chemistry 2007;7(7):727-37.
2007: John J Turner; Simon W Jones; Sterghios A Moschos; Mark A Lindsay; Michael J Gait
MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity.
Molecular bioSystems 2007;3(1):43-50.
2007: John J Turner; Simon Jones; Martin M Fabani; Gabriela Ivanova; Andrey A Arzumanov; Michael J Gait
RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.
Blood cells, molecules & diseases 2007;38(1):1-7.
2006: Gabriela Ivanova; Andrey A Arzumanov; John J Turner; Sandrine Reigadas; Jean-Jacques Toulmé; Douglas E Brown; Andrew M L Lever; Michael J Gait
Anti-HIV activity of steric block oligonucleotides.
Annals of the New York Academy of Sciences 2006;1082():103-15.
2006: John J Turner; Donna Williams; David Owen; Michael J Gait
Disulfide conjugation of peptides to oligonucleotides and their analogs.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2006;Chapter 4():Unit 4.28.
2006: Martin M Fabani; John J Turner; Michael J Gait
Oligonucleotide analogs as antiviral agents.
Current opinion in molecular therapeutics 2006;8(2):108-14.
2006: John J Turner; Martin M Fabani; Andrey A Arzumanov; Gabriela Ivanova; Michael J Gait
Targeting the HIV-1 RNA leader sequence with synthetic oligonucleotides and siRNA: chemistry and cell delivery.
Biochimica et biophysica acta 2006;1758(3):290-300.
2006: Saïd Abes; Donna Williams; Paul Prevot; Alain THIERRY; Michael J Gait; Bernard Lebleu
Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates.
Journal of controlled release : official journal of the Controlled Release Society 2006;110(3):595-604.
2006: Douglas E Brown; Andrey A Arzumanov; Sana Syed; Michael J Gait; Andrew M L Lever
Inhibition of HIV-1 replication by oligonucleotide analogues directed to the packaging signal and trans-activating response region.
Antiviral chemistry & chemotherapy 2006;17(1):1-9.
2005: Eugeny M Zubin; Dmitry A Stetsenko; Timofei S Zatsepin; Michael J Gait; Tatiana S Oretskaya
Oligonucleotides containing 2'-O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine as suitable precursors of 2'-aldehyde oligonucleotides for chemoselective ligation.
Bioorganic & medicinal chemistry 2005;13(16):4912-20.
2005: Timofei S Zatsepin; Dmitry A Stetsenko; Michael J Gait; Tatiana S Oretskaya
Use of carbonyl group addition--elimination reactions for synthesis of nucleic acid conjugates.
Bioconjugate chemistry 2005;16(3):471-89.
2005: Gaelle Kolb; Sandrine Reigadas; Claudine Boiziau; Arthur Van Aerschot; Andrey A Arzumanov; Michael J Gait; Piet Herdewijn; Jean-Jacques Toulmé
Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA.
Biochemistry 2005;44(8):2926-33.
2005: Eugeny M Zubin; Dmitry A Stetsenko; Anna V Kachalova; Michael J Gait; Tatiana S Oretskaya
Incorporation of side-chain groups of basic amino acids into oligonucleotides via the 2'-position of uridine.
Nucleic acids symposium series (2004) 2005;(49):347-8.
2005: Timofei S Zatsepin; Dmitry A Stetsenko; Michael J Gait; Tatiana S Oretskaya
2'-Hydrazine oligonucleotides: synthesis and efficient conjugation with aldehydes.
Nucleic acids symposium series (2004) 2005;(49):133-4.
2005: John J Turner; Gabriela Ivanova; Birgit Verbeure; Donna Williams; Andrey A Arzumanov; Saïd Abes; Bernard Lebleu; Michael J Gait
Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells.
Nucleic acids research 2005;33(21):6837-49.
2005: Douglas Brown; Andrey A Arzumanov; John J Turner; Dmitry A Stetsenko; Andrew M L Lever; Michael J Gait
Antiviral activity of steric-block oligonucleotides targeting the HIV-1 trans-activation response and packaging signal stem-loop RNAs.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):393-6.
2005: Ming Jiang; Andrey A Arzumanov; Michael J Gait; Jo Milner
A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification.
Nucleic acids research 2005;33(18):e151.
2005: John J Turner; Andrey A Arzumanov; Michael J Gait
Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides.
Nucleic acids research 2005;33(1):27-42.
2005: Dmitry A Stetsenko; Michael J Gait
Chemical methods for peptide-oligonucleotide conjugate synthesis.
Methods in molecular biology (Clifton, N.J.) 2005;288():205-24.
2004: Meredith F Ross; Aleksandra Filipovska; Robin A J Smith; Michael J Gait; Michael P Murphy
Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers.
The Biochemical journal 2004;383(Pt. 3):457-68.
2004: Arthur Abelian; Andrew P Walsh; Georg Lentzen; Fareed Aboul-Ela; Michael J Gait
Targeting the A site RNA of the Escherichia coli ribosomal 30 S subunit by 2'-O-methyl oligoribonucleotides: a quantitative equilibrium dialysis binding assay and differential effects of aminoglycoside antibiotics.
The Biochemical journal 2004;383(Pt 2):201-8.
2004: Anna Kachalova; Eugeny M Zubin; Dmitry Stetsenko; Michael J Gait; Tatiana S Oretskaya
Oligonucleotides with 2'-O-carboxymethyl group: synthesis and 2'-conjugation via amide bond formation on solid phase.
Organic & biomolecular chemistry 2004;2(19):2793-7.
2004: Timofei S Zatsepin; Michael J Gait; Tatiana S Oretskaya
2'-Functionalized nucleic acids as structural tools in molecular biology.
IUBMB life 2004;56(4):209-14.
2004: Anna V Kachalova; Dmitry A Stetsenko; Michael J Gait; Tatiana S Oretskaya
Synthesis of oligonucleotide 2'-conjugates via amide bond formation in solution.
Bioorganic & medicinal chemistry letters 2004;14(3):801-4.
2004: Vladimir A Korshun; Dmitry A Stetsenko; Michael J Gait
Uridine 2'-carbamates: facile tools for oligonucleotide 2'-functionalization.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2004;Chapter 4():Unit 4.21.
2003: Natalia N Dioubankova; Andrei D Malakhov; Dmitry A Stetsenko; Michael J Gait; Pavel E Volynsky; Roman G Efremov; Vladimir A Korshun
Pyrenemethyl ara-uridine-2'-carbamate: a strong interstrand excimer in the major groove of a DNA duplex.
Chembiochem : a European journal of chemical biology 2003;4(9):841-7.
2003: Stephen C Holmes; Andrey A Arzumanov; Michael J Gait
Steric inhibition of human immunodeficiency virus type-1 Tat-dependent trans-activation in vitro and in cells by oligonucleotides containing 2'-O-methyl G-clamp ribonucleoside analogues.
Nucleic acids research 2003;31(11):2759-68.
2003: Timofei S Zatsepin; Elena A Romanova; Dmitry A Stetsenko; Michael J Gait; Tatiana S Oretskaya
Synthesis of 2'-modified oligonucleotides containing aldehyde or ethylenediamine groups.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1383-5.
2003: Dmitry A Stetsenko; Andrei D Malakhov; Michael J Gait
Total stepwise solid-phase peptide-oligonucleotide conjugate synthesis on macroporous polystyrene.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1379-82.
2003: Eugeny M Zubin; Dmitry A Stetsenko; Tatiana S Oretskaya; Michael J Gait
1,2-Diol and hydrazide phosphoramidites for solid-phase synthesis and chemoselective ligation of 2'-modified oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1375-8.
2003: Stephen C Holmes; Michael J Gait
The synthesis of 2'-O-methyl G-clamp containing oligonucleotides and their inhibition of the HIV-1 Tat-TAR interaction.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1259-62.
2003: Jesper Wengel; Birte Vester; Lars Bo Lundberg; Stephen Douthwaite; Mads D Sørensen; B Ravindra Babu; Michael J Gait; Andrey A Arzumanov; Michael Petersen; Jakob T Nielsen
LNA and alpha-L-LNA: towards therapeutic applications.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):601-4.
2003: Anna V Kachalova; V N Tashlitskiĭ; Dmitry A Stetsenko; Elena A Romanova; Michael J Gait; TS Oretskaia
[Solid phase synthesis and chromatographic characteristics of nucleophilic agents conjugated with oligonucleotides containing 5'-terminal carboxyl group].
Bioorganicheskaia khimiia 2003;29(3):303-9.
2003: Michael J Gait
Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues.
Cellular and molecular life sciences : CMLS 2003;60(5):844-53.
2003: Jean Philippe Richard; Kamran Melikov; Eric Vives; Corinne Ramos; Birgit Verbeure; Michael J Gait; Leonid V Chernomordik; Bernard Lebleu
Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake.
The Journal of biological chemistry 2003;278(1):585-90.
2003: Andrey A Arzumanov; Dmitry A Stetsenko; Andrei D Malakhov; Stefanie Reichelt; Mads D Sørensen; B Ravindra Babu; Jesper Wengel; Michael J Gait
A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues.
Oligonucleotides 2003;13(6):435-53.
2002: Natalia N Dioubankova; Andrei D Malakhov; Dmitry A Stetsenko; Vladimir A Korshun; Michael J Gait
(R)-2,4-Dihydroxybutyramide seco-pseudonucleosides: new versatile homochiral synthons for synthesis of modified oligonucleotides.
Organic letters 2002;4(26):4607-10.
2002: Fabien Darfeuille; Andrey A Arzumanov; Michael J Gait; Carmelo Di Primo; Jean-Jacques Toulmé
2'-O-methyl-RNA hairpins generate loop-loop complexes and selectively inhibit HIV-1 Tat-mediated transcription.
Biochemistry 2002;41(40):12186-92.
2002: Dmitry A Stetsenko; Andrei D Malakhov; Michael J Gait
Total stepwise solid-phase synthesis of oligonucleotide-(3'-->N)-peptide conjugates.
Organic letters 2002;4(19):3259-62.
2002: Fabien Darfeuille; Andrey A Arzumanov; Sergei Gryaznov; Michael J Gait; Carmelo Di Primo; Jean-Jacques Toulmé
Loop-loop interaction of HIV-1 TAR RNA with N3'-->P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9709-14.
2002: Timofei S Zatsepin; Dmitry A Stetsenko; Andrey A Arzumanov; Elena A Romanova; Michael J Gait; Tatiana S Oretskaya
Synthesis of peptide-oligonucleotide conjugates with single and multiple peptides attached to 2'-aldehydes through thiazolidine, oxime, and hydrazine linkages.
Bioconjugate chemistry 2002;13(4):822-30.
2001: Andrey A Arzumanov; Andrew P Walsh; V K Rajwanshi; R Kumar; Jesper Wengel; Michael J Gait
Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.
Biochemistry 2001;40(48):14645-54.
2001: K Stolze; Stephen C Holmes; DJ Earnshaw; M Singh; Dmitry A Stetsenko; D Williams; Michael J Gait
Novel spermine-amino acid conjugates and basic tripeptides enhance cleavage of the hairpin ribozyme at low magnesium ion concentration.
Bioorganic & medicinal chemistry letters 2001;11(23):3007-10.
2001: Dmitry A Stetsenko; Michael J Gait
A convenient solid-phase method for synthesis of 3'-conjugates of oligonucleotides.
Bioconjugate chemistry 2001;12(4):576-86.
2001: Michael J Gait; C Lehmann
A base-labile protecting group (fluorenylmethoxycarbonyl) for the 5'-hydroxy function of nucleosides.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2001;Chapter 2():Unit 2.4.
2001: Dmitry A Stetsenko; Michael J Gait
A new "native ligation" procedure for peptide-oligonucleotide conjugation.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):801-4.
2001: Andrey A Arzumanov; Andrew P Walsh; X Liu; V K Rajwanshi; Jesper Wengel; Michael J Gait
Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):471-80.
2001: Dmitry A Stetsenko; D Williams; Michael J Gait
Synthesis of peptide-oligonucleotide conjugates: application to basic peptides.
Nucleic acids research. Supplement (2001) 2001;(1):153-4.
2001: Timofei S Zatsepin; Anna V Kachalova; Elena A Romanova; D A Stestenko; Michael J Gait; TS Oretskaia
[Synthesis and characteristics of modified oligodeoxyribonucleotides containing 2'-O-(2,3-dihydroxypropyl)uridine and 2'-O-(2-exoethyl)uridine].
Bioorganicheskaia khimiia 2001;27(1):45-51.
2000: Dmitry A Stetsenko; Andrey A Arzumanov; Vladimir A Korshun; Michael J Gait
[Peptide-oligonucleotide conjugates as a new generation of antisense elements].
Molekuliarnaia biologiia 2000;34(6):998-1006.
2000: Dmitry A Stetsenko; Michael J Gait
New phosphoramidite reagents for the synthesis of oligonucleotides containing a cysteine residue useful in peptide conjugation.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1751-64.
2000: Anna V Kachalova; Timofei S Zatsepin; Elena A Romanova; Dmitry A Stetsenko; Michael J Gait; Tatiana S Oretskaya
Synthesis of modified nucleotide building blocks containing electrophilic groups in the 2'-position.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1693-707.
2000: Dmitry A Stetsenko; Michael J Gait
Efficient conjugation of peptides to oligonucleotides by "native ligation".
The Journal of organic chemistry 2000;65(16):4900-8.
2000: DJ Earnshaw; M L Hamm; J A Piccirilli; Alexander Karpeisky; Leonid Beigelman; B S Ross; M Manoharan; Michael J Gait
Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides.
Biochemistry 2000;39(21):6410-21.
1999: B Mestre; Andrey A Arzumanov; M Singh; F Boulmé; Simon Litvak; Michael J Gait
Oligonucleotide inhibition of the interaction of HIV-1 Tat protein with the trans-activation responsive region (TAR) of HIV RNA.
Biochimica et biophysica acta 1999;1445(1):86-98.
1999: DJ Earnshaw; Michael J Gait
The harpin ribozyme: the roles of ions in RNA cleavage.
Nucleic acids symposium series 1999;(42):273-4.
1998: DJ Earnshaw; Michael J Gait
Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions.
Nucleic acids research 1998;26(24):5551-61.
1998: E A Taran; MG Ivanovskaia; Michael J Gait; ZA Shabarova
[Covalent binding of RNA with peptides in the structure of a specific complex using N-oxybenzotriazole oligoribonucleotide esters].
Molekuliarnaia biologiia 1998;32(5):832-9.
1998: Nikolai Naryshkin; Michael J Gait; Marina Ivanovskaya
RNA recognition and regulation of HIV-1 gene expression by viral factor Tat.
Biochemistry. Biokhimii͡a 1998;63(5):489-503.
1998: M A Farrow; Fareed Aboul-Ela; D Owen; Alexander Karpeisky; Leonid Beigelman; Michael J Gait
Site-specific cross-linking of amino acids in the basic region of human immunodeficiency virus type 1 Tat peptide to chemically modified TAR RNA duplexes.
Biochemistry 1998;37(9):3096-108.
1997: DJ Earnshaw; Benoît Masquida; S Müller; S T Sigurdsson; F Eckstein; E Westhof; Michael J Gait
Inter-domain cross-linking and molecular modelling of the hairpin ribozyme.
Journal of molecular biology 1997;274(2):197-212.
1997: DJ Earnshaw; Michael J Gait
Progress toward the structure and therapeutic use of the hairpin ribozyme.
Antisense & nucleic acid drug development 1997;7(4):403-11.
1997: Nikolai Naryshkin; M A Farrow; Marina Ivanovskaya; Tatiana S Oretskaya; ZA Shabarova; Michael J Gait
Chemical cross-linking of the human immunodeficiency virus type 1 Tat protein to synthetic models of the RNA recognition sequence TAR containing site-specific trisubstituted pyrophosphate analogues.
Biochemistry 1997;36(12):3496-505.
1996: N A Naryshkin; M G Ivanovskaia; T S Oretskaia; Eugeny M Volkov; Michael J Gait; ZA Shabarova
[Synthesis and properties of mixed ribodeoxyribooligonucleotide duplexes containing an internucleotide trisubstituted pyrophosphate bond].
Bioorganicheskaia khimiia 1996;22(9):691-8.
1996: I Mikaélian; M Krieg; Michael J Gait; Jonathan Karn
Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs.
Journal of molecular biology 1996;257(2):246-64.
1996: N J Keen; Michael J Gait; Jonathan Karn
Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2505-10.
1996: S Schmidt; Leonid Beigelman; Alexander Karpeisky; N Usman; U S Sorensen; Michael J Gait
Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure.
Nucleic acids research 1996;24(4):573-81.
1995: William G Scott; J T Finch; R Grenfell; J Fogg; T Smith; Michael J Gait; Aaron Klug
Rapid crystallization of chemically synthesized hammerhead RNAs using a double screening procedure.
Journal of molecular biology 1995;250(3):327-32.
1995: K Rittner; M J Churcher; Michael J Gait; Jonathan Karn
The human immunodeficiency virus long terminal repeat includes a specialised initiator element which is required for Tat-responsive transcription.
Journal of molecular biology 1995;248(3):562-80.
1995: J A Grasby; K Mersmann; M Singh; Michael J Gait
Purine functional groups in essential residues of the hairpin ribozyme required for catalytic cleavage of RNA.
Biochemistry 1995;34(12):4068-76.
1995: M J Churcher; A D Lowe; Michael J Gait; Jonathan Karn
The RNA element encoded by the trans-activation-responsive region of human immunodeficiency virus type 1 is functional when displaced downstream of the start of transcription.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2408-12.
1994: D A Mann; I Mikaélian; R W Zemmel; S M Green; A D Lowe; T Kimura; M Singh; P Jonathan G Butler; Michael J Gait; Jonathan Karn
A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression.
Journal of molecular biology 1994;241(2):193-207.
1994: C E Pritchard; J A Grasby; François Hamy; A M Zacharek; M Singh; Jonathan Karn; Michael J Gait
Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteins.
Nucleic acids research 1994;22(13):2592-600.
1994: J A Grasby; Michael J Gait
Synthetic oligoribonucleotides carrying site-specific modifications for RNA structure-function analysis.
Biochimie 1994;76(12):1223-34.
1993: J A Grasby; P Jonathan; G Butler; Michael J Gait
The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage.
Nucleic acids research 1993;21(19):4444-50.
1993: M A Graeble; M J Churcher; A D Lowe; Michael J Gait; Jonathan Karn
Human immunodeficiency virus type 1 transactivator protein, tat, stimulates transcriptional read-through of distal terminator sequences in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6184-8.
1993: Michael J Gait; Jonathan Karn
RNA recognition by the human immunodeficiency virus Tat and Rev proteins.
Trends in biochemical sciences 1993;18(7):255-9.
1993: M J Churcher; C Lamont; François Hamy; C Dingwall; S M Green; A D Lowe; J G Butler; Michael J Gait; Jonathan Karn
High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region.
Journal of molecular biology 1993;230(1):90-110.
1993: François Hamy; U Asseline; J Grasby; S Iwai; C Pritchard; G Slim; P J Butler; Jonathan Karn; Michael J Gait
Hydrogen-bonding contacts in the major groove are required for human immunodeficiency virus type-1 tat protein recognition of TAR RNA.
Journal of molecular biology 1993;230(1):111-23.
1993: U Asseline; J Grasby; François Hamy; S Iwai; D A Mann; C Pritchard; Jonathan Karn; Michael J Gait
HIV gene regulatory proteins tat and rev and their interactions with synthetic RNA.
Nucleic acids symposium series 1993;(29):113-4.
1992: S Iwai; C Pritchard; D A Mann; Jonathan Karn; Michael J Gait
Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein.
Nucleic acids research 1992;20(24):6465-72.
1992: G Slim; Michael J Gait
The role of the exocyclic amino groups of conserved purines in hammerhead ribozyme cleavage.
Biochemical and biophysical research communications 1992;183(2):605-9.
1991: Shaun Heaphy; J T Finch; Michael J Gait; Jonathan Karn; M Singh
Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7366-70.
1991: G Slim; Michael J Gait
Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes.
Nucleic acids research 1991;19(6):1183-8.
1991: Jonathan Karn; C Dingwall; J T Finch; Shaun Heaphy; Michael J Gait
RNA binding by the tat and rev proteins of HIV-1.
Biochimie 1991;73(1):9-16.
1991: G Slim; C Pritchard; E Biala; U Asseline; Michael J Gait
Synthesis of site-specifically modified oligoribonucleotides for studies of the recognition of TAR RNA by HIV-1 tat protein and studies of hammerhead ribozymes.
Nucleic acids symposium series 1991;(24):55-8.
1991: S J Fowler; I Durrant; Michael J Gait; K Misiura; M R Evans
Applications of oligonucleotides bearing single and multiple labels introduced during synthesis.
Nucleic acids symposium series 1991;(24):221.
1990: C Dingwall; I Ernberg; Michael J Gait; S M Green; Shaun Heaphy; Jonathan Karn; A D Lowe; M Singh; M A Skinner
HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure.
The EMBO journal 1990;9(12):4145-53.
1990: K Misiura; I Durrant; M R Evans; Michael J Gait
Biotinyl and phosphotyrosinyl phosphoramidite derivatives useful in the incorporation of multiple reporter groups on synthetic oligonucleotides.
Nucleic acids research 1990;18(15):4345-54.
1990: Shaun Heaphy; C Dingwall; I Ernberg; Michael J Gait; S M Green; Jonathan Karn; A D Lowe; M Singh; M A Skinner
HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region.
Cell 1990;60(4):685-93.
1989: C Dingwall; I Ernberg; Michael J Gait; S M Green; Shaun Heaphy; Jonathan Karn; A D Lowe; M Singh; M A Skinner; R Valerio
Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):6925-9.
1989: C Lehmann; Y Z Xu; C Christodoulou; Z K Tan; Michael J Gait
Solid-phase synthesis of oligoribonucleotides using 9-fluorenylmethoxycarbonyl (Fmoc) for 5'-hydroxyl protection.
Nucleic acids research 1989;17(7):2379-90.
1989: Y Z Xu; C Lehmann; G Slim; C Christodoulou; Z K Tan; Michael J Gait
Solid-phase synthesis of oligoribonucleotides.
Nucleic acids symposium series 1989;(21):39-40.
1988: Heii Arai; P C Emson; S Agrawal; C Christodoulou; Michael J Gait
In situ hybridization histochemistry: localisation of vasopressin mRNA in rat brain using a biotinylated oligonucleotide probe.
Brain research 1988;464(1):63-9.
1987: Shaun Heaphy; M Singh; Michael J Gait
Cloning and expression in E. coli of a synthetic gene for the bacteriocidal protein caltrin/seminalplasmin.
Protein engineering 1987;1(5):425-31.
1987: Shaun Heaphy; M Singh; Michael J Gait
Effect of single amino acid changes in the region of the adenylylation site of T4 RNA ligase.
Biochemistry 1987;26(6):1688-96.
1986: M Singh; Shaun Heaphy; Michael J Gait
Oligonucleotide-directed misincorporation mutagenesis on single-stranded DNA templates.
Protein engineering 1986;1(1):75-6.
1986: S Agrawal; C Christodoulou; Michael J Gait
Efficient methods for attaching non-radioactive labels to the 5' ends of synthetic oligodeoxyribonucleotides.
Nucleic acids research 1986;14(15):6227-45.