FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Consuelo Gajate

Research Profile

Chemicals & Drugs

Anatomy

Physiology

Living Beings

Mouse

Co-author Network

Publications

TOP 3
Ana Burgeiro; Consuelo Gajate; Ana C Bento; Paulo J Oliveira; Faustino Mollinedo
Rapid human melanoma cell death induced by sanguinarine through oxidative stress.
Álvaro Cuesta-Marbán; José Luis Revuelta; Vanina Zaremberg; Hui Zhang; A Ulises Acuña; Francisco Amat-Guerri; Javier Botet; Luis M Cacharro; Ola Czyz; Javier Delgado; Consuelo Gajate; Valentín Hornillos; Christopher R McMaster; Faustino Mollinedo
Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast.
Consuelo Gajate; M Matos-da-Silva; J Alvarez; Rosalba I Fonteriz; el-H Dakir; Faustino Mollinedo
Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Consuelo Gajate (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Ana Burgeiro; Consuelo Gajate; Ana C Bento; Paulo J Oliveira; Faustino Mollinedo
Rapid human melanoma cell death induced by sanguinarine through oxidative stress.
European journal of pharmacology 2013;705(1-3):109-18.
2013: Álvaro Cuesta-Marbán; José Luis Revuelta; Vanina Zaremberg; Hui Zhang; A Ulises Acuña; Francisco Amat-Guerri; Javier Botet; Luis M Cacharro; Ola Czyz; Javier Delgado; Consuelo Gajate; Valentín Hornillos; Christopher R McMaster; Faustino Mollinedo
Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast.
The Journal of biological chemistry 2013;288(12):8405-18.
2012: Consuelo Gajate; M Matos-da-Silva; J Alvarez; Rosalba I Fonteriz; el-H Dakir; Faustino Mollinedo
Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.
Oncogene 2012;31(21):2627-39.
2011: Consuelo Gajate; Faustino Mollinedo
Lipid rafts and Fas/CD95 signaling in cancer chemotherapy.
Recent patents on anti-cancer drug discovery 2011;6(3):274-83.
2011: Ana Burgeiro; Consuelo Gajate; Janny A Villa-Pulgarín; Paulo J Oliveira; El Habib Dakir; Faustino Mollinedo
Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells.
Anti-cancer drugs 2011;22(6):507-18.
2011: Faustino Mollinedo; M Fernández; V Hornillos; J Delgado; Francisco Amat-Guerri; A Ulises Acuña; T Nieto-Miguel; J A Villa-Pulgarín; C González-García; V Ceña; Consuelo Gajate
Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.
Cell death & disease 2011;2():e158.
2010: Faustino Mollinedo; Janis de la Iglesia-Vicente; Consuelo Gajate; A Estella-Hermoso de Mendoza; Janny Alexander Villa-Pulgarin; Miguel Angel Campanero; María J Blanco-Prieto
Lipid raft-targeted therapy in multiple myeloma.
Oncogene 2010;29(26):3748-57.
2010: Faustino Mollinedo; Consuelo Gajate
Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.
Future oncology (London, England) 2010;6(5):811-21.
2010: Faustino Mollinedo; Consuelo Gajate
Lipid rafts, death receptors and CASMERs: new insights for cancer therapy.
Future oncology (London, England) 2010;6(4):491-4.
2010: Faustino Mollinedo; Janis de la Iglesia-Vicente; Consuelo Gajate; Ander Estella-Hermoso de Mendoza; Janny Alexander Villa-Pulgarin; Mercè de Frias; Gaël Roué; Joan Gil; Dolors Colomer; Miguel A Campanero; María J Blanco-Prieto
In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(7):2046-54.
2009: M Reis-Sobreiro; Consuelo Gajate; Faustino Mollinedo
Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.
Oncogene 2009;28(36):3221-34.
2009: Faustino Mollinedo; Consuelo Gajate; Ana I Morales; Esther del Canto-Jañez; Nicole Justies; Francisco Collía; Juan V Rivas; Manuel Modolell; Antonio Iglesias
Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.
The Journal of pharmacology and experimental therapeutics 2009;329(2):439-49.
2009: Consuelo Gajate; Fernando Gonzalez-Camacho; Faustino Mollinedo
Lipid raft connection between extrinsic and intrinsic apoptotic pathways.
Biochemical and biophysical research communications 2009;380(4):780-4.
2009: Ander Estella-Hermoso de Mendoza; Miguel A Campanero; Janis de la Iglesia-Vicente; Consuelo Gajate; Faustino Mollinedo; María J Blanco-Prieto
Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):858-64.
2009: Consuelo Gajate; Fernando Gonzalez-Camacho; Faustino Mollinedo
Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells.
PloS one 2009;4(4):e5044.
2008: Alessio Ausili; Alejandro Torrecillas; Francisco J Aranda; Faustino Mollinedo; Consuelo Gajate; Senena Corbalan-Garcia; Ana de Godos; Juan C Gómez-Fernández
Edelfosine is incorporated into rafts and alters their organization.
The journal of physical chemistry. B 2008;112(37):11643-54.
2008: Faustino Mollinedo; Ricardo López-Pérez; Consuelo Gajate
Differential gene expression patterns coupled to commitment and acquisition of phenotypic hallmarks during neutrophil differentiation of human leukaemia HL-60 cells.
Gene 2008;419(1-2):16-26.
2008: Constantine S Mitsiades; Enrique M Ocio; Atanasio Pandiella; Patricia Maiso; Consuelo Gajate; Mercedes Garayoa; David Vilanova; Juan Carlos Montero; Nicholas Mitsiades; Ciaran J McMullan; Nikhil C Munshi; Teru Hideshima; Dharminder Chauhan; Pablo Aviles; Gabriel Otero; Glynn Faircloth; M Victoria Mateos; Paul G Richardson; Faustino Mollinedo; Jesus F San-Miguel; Kenneth C Anderson
Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo.
Cancer research 2008;68(13):5216-25.
2008: T Nieto-Miguel; Consuelo Gajate; F González-Camacho; Faustino Mollinedo
Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy.
Oncogene 2008;27(12):1779-87.
2007: Teresa Nieto-Miguel; Rosalba I Fonteriz; Laura Vay; Consuelo Gajate; Silvia López-Hernández; Faustino Mollinedo
Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.
Cancer research 2007;67(21):10368-78.
2007: Hui Zhang; Consuelo Gajate; Li-Ping Yu; Yun-Xiang Fang; Faustino Mollinedo
Mitochondrial-derived ROS in edelfosine-induced apoptosis in yeasts and tumor cells.
Acta pharmacologica Sinica 2007;28(6):888-94.
2007: Consuelo Gajate; Faustino Mollinedo
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.
Blood 2007;109(2):711-9.
2006: Faustino Mollinedo; Jero Calafat; Hans Janssen; Belén Martín-Martín; Javier Canchado; Svetlana M Nabokina; Consuelo Gajate
Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2831-41.
2006: Alejandro Torrecillas; J Daniel Aroca-Aguilar; Francisco J Aranda; Consuelo Gajate; Faustino Mollinedo; Senena Corbalan-Garcia; Ana de Godos; Juan C Gómez-Fernández
Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes.
International journal of pharmaceutics 2006;318(1-2):28-40.
2006: Teresa Nieto-Miguel; Consuelo Gajate; Faustino Mollinedo
Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells.
The Journal of biological chemistry 2006;281(21):14833-40.
2006: Faustino Mollinedo; Consuelo Gajate
Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2006;9(1-2):51-73.
2005: Vanina Zaremberg; Consuelo Gajate; Luis M Cacharro; Faustino Mollinedo; Christopher R McMaster
Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition.
The Journal of biological chemistry 2005;280(45):38047-58.
2005: Marie-Hélène David-Cordonnier; Consuelo Gajate; Osvaldo Olmea; William Laine; Janis de la Iglesia-Vicente; Carlos Perez; Carmen Cuevas; Gabriel Otero; Ignacio Manzanares; Christian Bailly; Faustino Mollinedo
DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.
Chemistry & biology 2005;12(11):1201-10.
2005: Consuelo Gajate; Faustino Mollinedo
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.
The Journal of biological chemistry 2005;280(12):11641-7.
2005: Ana B S Maya; Concepción Pérez-Melero; Carmen Mateo; Dulce Alonso; José Luis Fernández; Consuelo Gajate; Faustino Mollinedo; Rafael Peláez; Esther Caballero; Manuel Medarde
Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.
Journal of medicinal chemistry 2005;48(2):556-68.
2004: Faustino Mollinedo; Consuelo Gajate; Sonsoles Martín-Santamaría; Federico Gago
ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor.
Current medicinal chemistry 2004;11(24):3163-84.
2004: Ernesto Quesada; Javier Delgado; Consuelo Gajate; Faustino Mollinedo; A Ulises Acuña; Francisco Amat-Guerri
Fluorescent phenylpolyene analogues of the ether phospholipid edelfosine for the selective labeling of cancer cells.
Journal of medicinal chemistry 2004;47(22):5333-5.
2004: Consuelo Gajate; Esther Del Canto-Jañez; A Ulises Acuña; Francisco Amat-Guerri; Emilio Geijo; Antonio M Santos-Beneit; Robert J Veldman; Faustino Mollinedo
Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis.
The Journal of experimental medicine 2004;200(3):353-65.
2004: M Angeles Castro; José M Miguel del Corral; Marina Gordaliza; Pablo A García; María Antonia Gómez-Zurita; María Dolores García-Grávalos; Janis de la Iglesia-Vicente; Consuelo Gajate; Feiyun An; Faustino Mollinedo; Arturo San Feliciano
Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin.
Journal of medicinal chemistry 2004;47(5):1214-22.
2003: Faustino Mollinedo; Consuelo Gajate
Microtubules, microtubule-interfering agents and apoptosis.
Apoptosis : an international journal on programmed cell death 2003;8(5):413-50.
2003: Consuelo Gajate; Feiyun An; Faustino Mollinedo
Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(4):1535-45.
2002: Consuelo Gajate; Feiyun An; Faustino Mollinedo
Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.
The Journal of biological chemistry 2002;277(44):41580-9.
2002: Consuelo Gajate; Faustino Mollinedo
Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells.
Current drug metabolism 2002;3(5):491-525.
2001: Consuelo Gajate; Faustino Mollinedo
The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells.
Blood 2001;98(13):3860-3.
2000: Consuelo Gajate; Isabel Barasoain; José Manuel Andreu; Faustino Mollinedo
Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest.
Cancer research 2000;60(10):2651-9.
2000: Consuelo Gajate; Antonio M Santos-Beneit; Antonio Macho; M d Lazaro; Alma Hernandez de Rojas; Manuel Modolell; E Muñoz; Faustino Mollinedo
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells.
International journal of cancer. Journal international du cancer 2000;86(2):208-18.
2000: Consuelo Gajate; Rosalba I Fonteriz; C Cabaner; G Alvarez-Noves; Y Alvarez-Rodriguez; Manuel Modolell; Faustino Mollinedo
Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis.
International journal of cancer. Journal international du cancer 2000;85(5):674-82.
1999: C Cabaner; Consuelo Gajate; Antonio Macho; E Muñoz; Manuel Modolell; Faustino Mollinedo
Induction of apoptosis in human mitogen-activated peripheral blood T-lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system.
British journal of pharmacology 1999;127(4):813-25.
1999: Antonio Macho; Marco A Calzado; Juan Muñoz-Blanco; Consuelo Gómez-Díaz; Consuelo Gajate; Faustino Mollinedo; Plácido Navas; Eduardo Muñoz
Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium.
Cell death and differentiation 1999;6(2):155-65.
1998: Faustino Mollinedo; Belén Martín-Martín; Consuelo Gajate; Pedro A Lazo
Physiological activation of human neutrophils down-regulates CD53 cell surface antigen.
Journal of leukocyte biology 1998;63(6):699-706.
1998: Consuelo Gajate; Antonio M Santos-Beneit; Manuel Modolell; Faustino Mollinedo
Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine.
Molecular pharmacology 1998;53(4):602-12.
1997: Faustino Mollinedo; M Nakajima; Ana Llorens; E Barbosa; Sagrario Callejo; Consuelo Gajate; Angels Fabra
Major co-localization of the extracellular-matrix degradative enzymes heparanase and gelatinase in tertiary granules of human neutrophils.
The Biochemical journal 1997;327 ( Pt 3)():917-23.
1997: Maria Teresa Alonso; Consuelo Gajate; Faustino Mollinedo; Manuel Modolell; Javier Alvarez; Javier García-Sancho
Dissociation of the effects of the antitumour ether lipid ET-18-OCH3 on cytosolic calcium and on apoptosis.
British journal of pharmacology 1997;121(7):1364-8.
1997: Faustino Mollinedo; J L Fernández-Luna; Consuelo Gajate; Belén Martín-Martín; A Benito; R Martínez-Dalmau; Manuel Modolell
Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).
Cancer research 1997;57(7):1320-8.
1996: Consuelo Gajate; Maria Teresa Alonso; Thomas Schimmang; Faustino Mollinedo
C-Fos is not essential for apoptosis.
Biochemical and biophysical research communications 1996;218(1):267-72.
1994: Faustino Mollinedo; Consuelo Gajate; I Flores
Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2457-69.
1994: Faustino Mollinedo; Consuelo Gajate; Manuel Modolell
The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells.
The Biochemical journal 1994;302 ( Pt 2)():325-9.
1993: Faustino Mollinedo; Consuelo Gajate; A Tugores; I Flores; J R Naranjo
Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes.
The Biochemical journal 1993;294 ( Pt 1)():137-44.
1993: Faustino Mollinedo; D Perez-Sala; Consuelo Gajate; B Jimenez; P Rodriguez; J C Lacal
Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils.
FEBS letters 1993;326(1-3):209-14.
1991: Faustino Mollinedo; Consuelo Gajate; D L Schneider
Cytochrome b co-fractionates with gelatinase-containing granules in human neutrophils.
Molecular and cellular biochemistry 1991;105(1):49-60.