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Michael Gajhede

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Monica Fiorentini; Jette S Kastrup; Kristian Strømgaard; Anders Bach; Michael Gajhede
Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy.
Christine A Ussing; Philip K Ahring; Bente Frølund; Michael Gajhede; Camilla P Hansen; Anders A Jensen; Jette S Kastrup; Elsebet Ø Nielsen; Jette G Petersen; Line A H Rohde; Thomas Balle
Synthesis, pharmacology, and biostructural characterization of novel α4β2 nicotinic acetylcholine receptor agonists.
Kasper Harpsøe; Marianne L Jensen; Jette S Kastrup; Elsebet Ø Nielsen; Dan Peters; Daniel B Timmermann; Thomas Balle; Tino Dyhring; Michael Gajhede; Helle Hald; Philip K Ahring
Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors.

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All Publications

2013: Monica Fiorentini; Jette S Kastrup; Kristian Strømgaard; Anders Bach; Michael Gajhede
Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy.
Acta crystallographica. Section D, Biological crystallography 2013;69(Pt 4):587-94.
2013: Christine A Ussing; Philip K Ahring; Bente Frølund; Michael Gajhede; Camilla P Hansen; Anders A Jensen; Jette S Kastrup; Elsebet Ø Nielsen; Jette G Petersen; Line A H Rohde; Thomas Balle
Synthesis, pharmacology, and biostructural characterization of novel α4β2 nicotinic acetylcholine receptor agonists.
Journal of medicinal chemistry 2013;56(3):940-51.
2013: Kasper Harpsøe; Marianne L Jensen; Jette S Kastrup; Elsebet Ø Nielsen; Dan Peters; Daniel B Timmermann; Thomas Balle; Tino Dyhring; Michael Gajhede; Helle Hald; Philip K Ahring
Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors.
The Journal of biological chemistry 2013;288(4):2559-70.
2012: Lina Juknaitė; Jette S Kastrup; Birgitte Nielsen; David J Aitken; Zeinab Assaf; Lennart Bunch; Sophie Faure; Karla Frydenvang; Michael Gajhede; Thierry Gefflaut; Raminta Venskutonytė; Darryl S Pickering
Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors.
Journal of structural biology 2012;180(1):39-46.
2012: Raminta Venskutonytė; Anna Ceravalls de Rabassa; Philip K Ahring; Karla Frydenvang; Michael Gajhede; Helle Hald; Jette S Kastrup
Kainate induces various domain closures in AMPA and kainate receptors.
Neurochemistry international 2012;61(4):536-45.
2012: Line H Kristensen; Michael Lees; Anders L Nielsen; Lars Olsen; Paul Cloos; Charlotte Helgstrand; Kristian Helin; Jette S Kastrup; Michael Gajhede
Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.
The FEBS journal 2012;279(11):1905-14.
2012: Anders L Nielsen; Karen B Stephansen; Paul Cloos; Michael Gajhede; Charlotte Helgstrand; Kristian Helin; Jan B L Kristensen; Line H Kristensen; Michael Lees; Lars Olsen
Identification of catechols as histone-lysine demethylase inhibitors.
FEBS letters 2012;586(8):1190-4.
2012: Anders Bach; Celestine N Chi; Bettina H Clausen; Michael Gajhede; Per Jemth; Jette S Kastrup; Anders Skov Kristensen; Kate Lykke Lambertsen; Patrik Lundström; Magda Møller; Klaus B Nissen; Adam Round; Pernille L Sørensen; Bente Vestergaard; Kristian Strømgaard
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(9):3317-22.
2012: Line Aagot Hede Rohde; Philip K Ahring; Michael Gajhede; Kasper Harpsøe; Charlotte Helgstrand; Marianne L Jensen; Jette S Kastrup; Christian Krintel; Elsebet Ø Nielsen; Dan Peters; Thomas Balle
Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed.
The Journal of biological chemistry 2012;287(6):4248-59.
2012: Azadeh Shahsavar; Michael Gajhede; Jette S Kastrup; Jesper L Kristensen; Elsebet Ø Nielsen; Thomas Balle
Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHβE suggests a unique mode of antagonism.
PloS one 2012;7(8):e40757.
2011: Raminta Venskutonytė; Darryl S Pickering; Lennart Bunch; Karla Frydenvang; Michael Gajhede; Jette S Kastrup
Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate.
Journal of structural biology 2011;176(3):307-14.
2011: Brian Lohse; Anders L Nielsen; Lars Olsen; Rasmus P Clausen; Paul A C Cloos; Michael Gajhede; Charlotte Helgstrand; Jan B L Kristensen; Jesper L Kristensen
Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors.
Angewandte Chemie (International ed. in English) 2011;50(39):9100-3.
2011: Jan B L Kristensen; Jesper L Kristensen; Line H Kristensen; Anders L Nielsen; Lars Olsen; Charlotte Helgstrand; Lars Jørgensen; Lina Juknaite; Jette S Kastrup; Rasmus P Clausen; Michael Gajhede
Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases.
FEBS letters 2011;585(12):1951-6.
2011: Brian Lohse; Karl Agger; Michael Gajhede; Kristian Helin; Jesper L Kristensen; Line H Kristensen; Rasmus P Clausen
Inhibitors of histone demethylases.
Bioorganic & medicinal chemistry 2011;19(12):3625-36.
2011: Jens Holm; Mercedes Ferreras; Henrik Ipsen; Peter A Würtzen; Michael Gajhede; Jørgen Nedergaard Larsen; Kaare Lund; Michael D Spangfort
Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1.
The Journal of biological chemistry 2011;286(20):17569-78.
2011: Nikolaj Kulahin; Ole Kristensen; Kim K Rasmussen; Lars Olsen; Patrik Rydberg; Bente Vestergaard; Jette S Kastrup; Vladimir Berezin; Elisabeth Bock; Peter S Walmod; Michael Gajhede
Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule.
Structure (London, England : 1993) 2011;19(2):203-11.
2010: Xiaole Wang; Helle Hald; Heidi A Ernst; Jan Egebjerg; Kenneth Vielsted Christensen; Michael Gajhede; Jette S Kastrup; Osman Mirza
Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus.
Protein expression and purification 2010;71(2):179-83.
2010: Sylwia Owczarek; Darya Kiryushko; Marianne Hald Larsen; Jette Sandholm Kastrup; Michael Gajhede; Carmen Sandi; Vladimir Berezin; Elisabeth Bock; Vladislav Soroka
Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(4):1139-50.
2009: Monica Fiorentini; Ann Kallehauge Nielsen; Ole Kristensen; Jette S Kastrup; Michael Gajhede
Structure of the first PDZ domain of human PSD-93.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 12):1254-7.
2009: Elise Champion; Magali Remaud-Simeon; Lars K Skov; Jette S Kastrup; Michael Gajhede; Osman Mirza
The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 12):1309-14.
2009: Helle Hald; Philip K Ahring; Daniel B Timmermann; Tommy Liljefors; Michael Gajhede; Jette S Kastrup
Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
Journal of molecular biology 2009;391(5):906-17.
2009: Rasmus P Clausen; Peter Naur; Anders Skov Kristensen; Jeremy R Greenwood; Mette Strange; Hans Bräuner-Osborne; Anders A Jensen; Anne Sophie T Nielsen; Ulla Geneser; Lone M Ringgaard; Birgitte Nielsen; Darryl S Pickering; Lotte Brehm; Michael Gajhede; Povl Krogsgaard-Larsen; Jette S Kastrup
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Journal of medicinal chemistry 2009;52(15):4911-22.
2009: Karla Frydenvang; L Leanne Lash; Peter Naur; Pekka A Postila; Darryl S Pickering; Caleb M Smith; Michael Gajhede; Makoto Sasaki; Ryuichi Sakai; Olli T Pentikaïnen; Geoffrey T Swanson; Jette S Kastrup
Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.
The Journal of biological chemistry 2009;284(21):14219-29.
2009: Kasper B Hansen; Peter Naur; Natalie L Kurtkaya; Anders Skov Kristensen; Michael Gajhede; Jette S Kastrup; Stephen F Traynelis
Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(4):907-17.
2008: Christina Kasper; Karla Frydenvang; Peter Naur; Michael Gajhede; Darryl S Pickering; Jette S Kastrup
Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4.
FEBS letters 2008;582(29):4089-94.
2008: Kim K Rasmussen; Nikolaj Kulahin; Ole Kristensen; Jens-Christian Navarro Poulsen; Bent W Sigurskjold; Jette S Kastrup; Vladimir Berezin; Elisabeth Bock; Peter S Walmod; Michael Gajhede
Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.
Journal of molecular biology 2008;382(5):1113-20.
2008: Gabriel Paës; Lars K Skov; Michael O'Donohue; Caroline Rémond; Jette S Kastrup; Michael Gajhede; Osman Mirza
The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit.
Biochemistry 2008;47(28):7441-51.
2008: Gustav Røder; Ole Kristensen; Jette S Kastrup; Soren Buus; Michael Gajhede
Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 6):459-62.
2008: Nikolaj Kulahin; Vladislav V Kiselyov; Artur Kochoyan; Ole Kristensen; Jette S Kastrup; Vladimir Berezin; Elisabeth Bock; Michael Gajhede
Dimerization effect of sucrose octasulfate on rat FGF1.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 6):448-52.
2008: Anders Dysted Jørgensen; Jane Nøhr; Jette S Kastrup; Michael Gajhede; Bent W Sigurskjold; Jørgen Sauer; Dmitri I Svergun; Birte Svensson; Bente Vestergaard
Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution.
The Journal of biological chemistry 2008;283(21):14772-80.
2008: Mads Beich-Frandsen; Darryl S Pickering; Osman Mirza; Tommy N Johansen; Jeremy Greenwood; Bente Vestergaard; Arne Schousboe; Michael Gajhede; Tommy Liljefors; Jette S Kastrup
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.
Journal of medicinal chemistry 2008;51(5):1459-63.
2008: Ole Kristensen; Birthe Ross; Michael Gajhede
Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp.
Journal of molecular biology 2008;375(5):1469-76.
2007: Birgitte H Kaae; Kasper Harpsøe; Jette S Kastrup; Alberto Contreras Sanz; Darryl S Pickering; Bjørn Metzler; Rasmus P Clausen; Michael Gajhede; Per Sauerberg; Tommy Liljefors; Ulf Madsen
Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites.
Chemistry & biology 2007;14(11):1294-303.
2007: Helle Hald; Peter Naur; Darryl S Pickering; Desiree Sprogøe; Ulf Madsen; Daniel B Timmermann; Philip K Ahring; Tommy Liljefors; Arne Schousboe; Jan Egebjerg; Michael Gajhede; Jette S Kastrup
Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.
The Journal of biological chemistry 2007;282(35):25726-36.
2007: Peter Naur; Kasper B Hansen; Anders Skov Kristensen; Shashank M Dravid; Darryl S Pickering; Lars Olsen; Bente Vestergaard; Jan Egebjerg; Michael Gajhede; Stephen F Traynelis; Jette S Kastrup
Ionotropic glutamate-like receptor delta2 binds D-serine and glycine.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14116-21.
2007: Stine B Vogensen; Karla Frydenvang; Jeremy R Greenwood; Giovanna Postorino; Birgitte Nielsen; Darryl S Pickering; Bjarke Ebert; Ulrik Bølcho; Jan Egebjerg; Michael Gajhede; Jette S Kastrup; Tommy N Johansen; Rasmus P Clausen; Povl Krogsgaard-Larsen
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Journal of medicinal chemistry 2007;50(10):2408-14.
2007: Bente Vestergaard; Minna Groenning; Manfred Roessle; Jette S Kastrup; Marco van de Weert; James M Flink; Sven Frokjaer; Michael Gajhede; Dmitri I Svergun
A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils.
PLoS biology 2007;5(5):e134.
2007: Birthe Ross; Ole Kristensen; Dimitri Favre; Joël Walicki; Jette S Kastrup; Christian Widmann; Michael Gajhede
High resolution crystal structures of the p120 RasGAP SH3 domain.
Biochemical and biophysical research communications 2007;353(2):463-8.
2007: Nikolaj Kulahin; Vladislav V Kiselyov; Artur Kochoyan; Ole Kristensen; Jette S Kastrup; Vladimir Berezin; Elisabeth Bock; Michael Gajhede
Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 2):65-8.
2007: Cécile Albenne; Lars K Skov; Vinh Tran; Michael Gajhede; Pierre Monsan; Magali Remaud-Siméon; Gwénaëlle André-Leroux
Towards the molecular understanding of glycogen elongation by amylosucrase.
Proteins 2007;66(1):118-26.
2006: Thomas Blicher; Jette S Kastrup; Lars Østergaard Pedersen; Soren Buus; Michael Gajhede
Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 12):1179-84.
2006: Osman Mirza; Lars K Skov; Desiree Sprogøe; Lambertus van den Broek; Gerrit Beldman; Jette S Kastrup; Michael Gajhede
Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion.
The Journal of biological chemistry 2006;281(46):35576-84.
2006: Gustav Røder; Thomas Blicher; Sune Justesen; Birthe Johannesen; Ole Kristensen; Jette Kastrup; Soren Buus; Michael Gajhede
Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 11):1300-10.
2006: Kåre Meno; Peter B Thorsted; Henrik Ipsen; Ole Kristensen; Jørgen Nedergaard Larsen; Michael D Spangfort; Michael Gajhede; Kaare Lund
The metal binding site of the major house dust mite allergen Der p 1.
The Journal of allergy and clinical immunology 2006;118(4):971.
2006: Lars K Skov; Ulla Seppälä; Jeremy J F Coen; Neil Crickmore; Te Piao King; Rafael Monsalve; Jette S Kastrup; Michael D Spangfort; Michael Gajhede
Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 6):595-604.
2006: Christina Kasper; Darryl S Pickering; Osman Mirza; Lars Olsen; Anders Skov Kristensen; Jeremy R Greenwood; Tommy Liljefors; Arne Schousboe; Frank Wätjen; Michael Gajhede; Bent W Sigurskjold; Jette S Kastrup
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.
Journal of molecular biology 2006;357(4):1184-201.
2006: Ole Kristensen; Sylvie Guenat; Imran Dar; Nathalie Allaman-Pillet; Amar Abderrahmani; Mourad Ferdaoussi; Raphael Roduit; Fabienne Maurer; Jacques Beckmann; Jette S Kastrup; Michael Gajhede; Christophe Bonny
A unique set of SH3-SH3 interactions controls IB1 homodimerization.
The EMBO journal 2006;25(4):785-97.
2006: Bart A van der Veen; Lars K Skov; Gabrielle Potocki-Véronèse; Michael Gajhede; Pierre Monsan; Magali Remaud-Simeon
Increased amylosucrase activity and specificity, and identification of regions important for activity, specificity and stability through molecular evolution.
The FEBS journal 2006;273(4):673-81.
2005: Bente Vestergaard; Suparna Sanyal; Manfred Roessle; Liliana Mora; Richard H Buckingham; Jette S Kastrup; Michael Gajhede; Dmitri I Svergun; Måns Ehrenberg
The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure.
Molecular cell 2005;20(6):929-38.
2005: Mai Marie Holm; Peter Naur; Bente Vestergaard; Matthew T Geballe; Michael Gajhede; Jette S Kastrup; Stephen F Traynelis; Jan Egebjerg
A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study.
The Journal of biological chemistry 2005;280(42):35469-76.
2005: Charlotte S Jørgensen; Christa Trandum; Nanna Larsen; L Rebekka Ryder; Michael Gajhede; Lars K Skov; Peter Højrup; Vibeke Barkholt; Gunnar Houen
Conformational stability of calreticulin.
Protein and peptide letters 2005;12(7):687-93.
2005: Kåre Meno; Peter B Thorsted; Henrik Ipsen; Ole Kristensen; Jørgen Nedergaard Larsen; Michael D Spangfort; Michael Gajhede; Kaare Lund
The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3835-45.
2005: Nikolaj Kulahin; Christina Kasper; Ole Kristensen; Jette S Kastrup; Vladimir Berezin; Elisabeth Bock; Michael Gajhede
Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 9):858-60.
2005: Thomas Blicher; Jette S Kastrup; Soren Buus; Michael Gajhede
High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 8):1031-40.
2005: Bettina Bryde Nielsen; Darryl S Pickering; Jeremy R Greenwood; Lotte Brehm; Michael Gajhede; Arne Schousboe; Jette S Kastrup
Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP.
The FEBS journal 2005;272(7):1639-48.
2005: Anne Frandsen; Darryl S Pickering; Bente Vestergaard; Christina Kasper; Bettina Bryde Nielsen; Jeremy R Greenwood; Giuseppe Campiani; Caterina Fattorusso; Michael Gajhede; Arne Schousboe; Jette S Kastrup
Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2.
Molecular pharmacology 2005;67(3):703-13.
2005: Birthe R Johannessen; Lars K Skov; Jette S Kastrup; Ole Kristensen; Caroline Bolwig; Jørgen Nedergaard Larsen; Michael D Spangfort; Kaare Lund; Michael Gajhede
Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity.
FEBS letters 2005;579(5):1208-12.
2005: Peter Naur; Bente Vestergaard; Lars K Skov; Jan Egebjerg; Michael Gajhede; Jette S Kastrup
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate.
FEBS letters 2005;579(5):1154-60.
2005: Britt Petersson; Bettina Bryde Nielsen; Hanne Rasmussen; Ingrid K Larsen; Michael Gajhede; Peter E Nielsen; Jette S Kastrup
Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network.
Journal of the American Chemical Society 2005;127(5):1424-30.
2004: Jens Holm; Michael Gajhede; Mercedes Ferreras; Anette Henriksen; Henrik Ipsen; Jørgen Nedergaard Larsen; Lise Lund; Henrik H Jacobi; Anders Millner; Peter A Würtzen; Michael D Spangfort
Allergy vaccine engineering: epitope modulation of recombinant Bet v 1 reduces IgE binding but retains protein folding pattern for induction of protective blocking-antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5258-67.
2004: Ole Kristensen; Martin Laurberg; Anders Liljas; Jette S Kastrup; Michael Gajhede
Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family.
Biochemistry 2004;43(28):8894-900.
2004: Malene H Jensen; Osman Mirza; Cécile Albenne; Magali Remaud-Simeon; Pierre Monsan; Michael Gajhede; Lars K Skov
Crystal structure of the covalent intermediate of amylosucrase from Neisseria polysaccharea.
Biochemistry 2004;43(11):3104-10.
2004: Nikolaj Kulahin; Christina Kasper; Michael Gajhede; Vladimir Berezin; Elisabeth Bock; Jette S Kastrup
Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 3):591-3.
2004: Desiree Sprogøe; Lambertus van den Broek; Osman Mirza; Jette S Kastrup; Alphons G J Voragen; Michael Gajhede; Lars K Skov
Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis.
Biochemistry 2004;43(5):1156-62.
2004: Cécile Albenne; Lars K Skov; Osman Mirza; Michael Gajhede; Georges Feller; Salvino D'Amico; Gwénaëlle André; Gabrielle Potocki-Véronèse; Bart A van der Veen; Pierre Monsan; Magali Remaud-Simeon
Molecular basis of the amylose-like polymer formation catalyzed by Neisseria polysaccharea amylosucrase.
The Journal of biological chemistry 2004;279(1):726-34.
2003: Ole Kristensen; Michael Gajhede
Chaperone binding at the ribosomal exit tunnel.
Structure (London, England : 1993) 2003;11(12):1547-56.
2003: Imran Dar; Christophe Bonny; Jan Torleif Pedersen; Michael Gajhede; Ole Kristensen
Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2300-2.
2003: Michael D Spangfort; Osman Mirza; Henrik Ipsen; R J J Van Neerven; Michael Gajhede; Jørgen Nedergaard Larsen
Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3084-90.
2002: Lars K Skov; Osman Mirza; Desiree Sprogøe; Imran Dar; Magali Remaud-Simeon; Cécile Albenne; Pierre Monsan; Michael Gajhede
Oligosaccharide and sucrose complexes of amylosucrase. Structural implications for the polymerase activity.
The Journal of biological chemistry 2002;277(49):47741-7.
2002: Kåre Meno; Simon Jennings; Andrew T Smith; Anette Henriksen; Michael Gajhede
Structural analysis of the two horseradish peroxidase catalytic residue variants H42E and R38S/H42E: implications for the catalytic cycle.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 10 Pt 2):1803-12.
2002: Cécile Albenne; Lars K Skov; Osman Mirza; Michael Gajhede; Gabrielle Potocki-Véronèse; Pierre Monsan; Magali Remaud-Simeon
Maltooligosaccharide disproportionation reaction: an intrinsic property of amylosucrase from Neisseria polysaccharea.
FEBS letters 2002;527(1-3):67-70.
2002: Ole Kristensen; Martin Laurberg; Michael Gajhede
Crystallization of a stringent response factor from Aquifex aeolicus.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 7):1198-200.
2001: Anette Henriksen; Te Piao King; Osman Mirza; Rafael Monsalve; Kåre Meno; Henrik Ipsen; Jørgen Nedergaard Larsen; Michael Gajhede; Michael D Spangfort
Major venom allergen of yellow jackets, Ves v 5: structural characterization of a pathogenesis-related protein superfamily.
Proteins 2001;45(4):438-48.
2001: Kåre L Nielsen; Chiara Indiani; Anette Henriksen; Alessandro Feis; Maurizio Becucci; Michael Gajhede; Giulietta Smulevich; Karen G Welinder
Differential activity and structure of highly similar peroxidases. Spectroscopic, crystallographic, and enzymatic analyses of lignifying Arabidopsis thaliana peroxidase A2 and horseradish peroxidase A2.
Biochemistry 2001;40(37):11013-21.
2001: Dan Sørensen; Tommy Harder Nielsen; Carsten Christophersen; Jan Sørensen; Michael Gajhede
Cyclic lipoundecapeptide amphisin from Pseudomonas sp. strain DSS73.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 9):1123-4.
2001: Osman Mirza; Lars K Skov; Magali Remaud-Simeon; G Potocki de Montalk; Cécile Albenne; Pierre Monsan; Michael Gajhede
Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose.
Biochemistry 2001;40(30):9032-9.
2001: Lars K Skov; Osman Mirza; Anette Henriksen; G P De Montalk; Magali Remaud-Simeon; P Sarçabal; René-Marc Willemot; Pierre Monsan; Michael Gajhede
Amylosucrase, a glucan-synthesizing enzyme from the alpha-amylase family.
The Journal of biological chemistry 2001;276(27):25273-8.
2001: Jens Holm; G Baerentzen; Michael Gajhede; Henrik Ipsen; Jørgen Nedergaard Larsen; Henning Løwenstein; M Wissenbach; Michael D Spangfort
Molecular basis of allergic cross-reactivity between group 1 major allergens from birch and apple.
Journal of chromatography. B, Biomedical sciences and applications 2001;756(1-2):307-13.
2001: Michael Gajhede
Plant peroxidases: substrate complexes with mechanistic implications.
Biochemical Society transactions 2001;29(Pt 2):91-98.
2001: Anette Henriksen; Osman Mirza; Chiara Indiani; Kaare Teilum; Giulietta Smulevich; Karen G Welinder; Michael Gajhede
Structure of soybean seed coat peroxidase: a plant peroxidase with unusual stability and haem-apoprotein interactions.
Protein science : a publication of the Protein Society 2001;10(1):108-15.
2000: Lars Ostergaard; Kaare Teilum; Osman Mirza; Ole Mattsson; Morten Petersen; Karen G Welinder; john mundy; Michael Gajhede; Anette Henriksen
Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification.
Plant molecular biology 2000;44(2):231-43.
2000: Osman Mirza; Anette Henriksen; Henrik Ipsen; Jørgen Nedergaard Larsen; M Wissenbach; Michael D Spangfort; Michael Gajhede
Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):331-8.
2000: Osman Mirza; Anette Henriksen; Lars Ostergaard; Karen G Welinder; Michael Gajhede
Arabidopsis thaliana peroxidase N: structure of a novel neutral peroxidase.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 3):372-5.
2000: Lars K Skov; Osman Mirza; Anette Henriksen; G Potocki de Montalk; Magali Remaud-Simeon; P Sarcabal; René-Marc Willemot; Pierre Monsan; Michael Gajhede
Crystallization and preliminary X-ray studies of recombinant amylosucrase from Neisseria polysaccharea.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 2):203-5.
2000: Anette Henriksen; Uffe Anthoni; Tommy Harder Nielsen; Jan Sørensen; Carsten Christophersen; Michael Gajhede
Cyclic lipoundecapeptide tensin from Pseudomonas fluorescens strain 96.578.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 1)():113-5.
1999: Anette Henriksen; Andrew T Smith; Michael Gajhede
The structures of the horseradish peroxidase C-ferulic acid complex and the ternary complex with cyanide suggest how peroxidases oxidize small phenolic substrates.
The Journal of biological chemistry 1999;274(49):35005-11.
1999: Michael D Spangfort; Osman Mirza; L A Svensson; Jørgen Nedergaard Larsen; Michael Gajhede; Henrik Ipsen
Crystallization and preliminary X-ray analysis of birch-pollen allergen Bet v 1 in complex with a murine monoclonal IgG Fab' fragment.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 12):2035-6.
1998: Anette Henriksen; David J Schuller; Kåre Meno; Karen G Welinder; Andrew T Smith; Michael Gajhede
Structural interactions between horseradish peroxidase C and the substrate benzhydroxamic acid determined by X-ray crystallography.
Biochemistry 1998;37(22):8054-60.
1998: Anette Henriksen; Karen G Welinder; Michael Gajhede
Structure of barley grain peroxidase refined at 1.9-A resolution. A plant peroxidase reversibly inactivated at neutral pH.
The Journal of biological chemistry 1998;273(4):2241-8.
1997: Michael Gajhede; David J Schuller; Anette Henriksen; Andrew T Smith; Thomas L Poulos
Crystal structure of horseradish peroxidase C at 2.15 A resolution.
Nature structural biology 1997;4(12):1032-8.
1996: Michael Gajhede; P Osmark; Flemming M Poulsen; Henrik Ipsen; Jørgen Nedergaard Larsen; R J Joost van Neerven; C Schou; Henning Løwenstein; Michael D Spangfort
X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy.
Nature structural biology 1996;3(12):1040-5.
1996: Michael D Spangfort; Jørgen Nedergaard Larsen; Michael Gajhede
Crystallization and preliminary X-ray investigation at 2.0 A resolution of Bet v 1, a birch pollen protein causing IgE-mediated allergy.
Proteins 1996;26(3):358-60.
1996: T N Petersen; Anette Henriksen; Michael Gajhede
Structure of porcine pancreatic spasmolytic polypeptide at 1.95 A resolution.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 4):730-7.
1996: Anette Henriksen; N Aghajari; Kaj Frank Jensen; Michael Gajhede
A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase.
Biochemistry 1996;35(12):3803-9.
1996: Jes Dietrich; A Neisig; X Hou; A M Wegener; Michael Gajhede; Carsten Geisler
Role of CD3 gamma in T cell receptor assembly.
The Journal of cell biology 1996;132(3):299-310.
1995: Anette Henriksen; Michael Gajhede; P Baker; Andrew T Smith; Julian Burke
Crystallization and preliminary X-ray studies of recombinant horseradish peroxidase.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 1):121-3.
1994: N Aghajari; Kaj Frank Jensen; Michael Gajhede
Crystallization and preliminary X-ray diffraction studies on the Apo form of orotate phosphoribosyltransferase from Escherichia coli.
Journal of molecular biology 1994;241(2):292-4.
1993: Michael Gajhede; T N Petersen; Anette Henriksen; J F Petersen; Z Dauter; K S Wilson; L Thim
Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides.
Structure (London, England : 1993) 1993;1(4):253-62.
1992: Anette Henriksen; J F Petersen; A Svensson; J Hejgaard; Karen G Welinder; Michael Gajhede
Crystallization and preliminary X-ray diffraction studies of a peroxidase from barley grain.
Journal of molecular biology 1992;228(2):690-2.
1992: Michael Gajhede; L Thim; K H Jørgensen; S G Melberg
Pancreatic spasmolytic polypeptide: crystallization, circular dichroism analysis, and preliminary X-ray diffraction studies.
Proteins 1992;13(4):364-8.
1992: Carsten Geisler; Bent Rubin; S Caspar-Bauguil; E Champagne; A Vangsted; X Hou; Michael Gajhede
Structural mutations of C-domains in members of the Ig superfamily. Consequences for the interactions between the T cell antigen receptor and the zeta 2 homodimer.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(11):3469-77.