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Zygmunt Galdzicki

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TOP 3
Tyler K Best; Lina Chakrabarti; Nathan P Cramer; Tarik F Haydar; Zygmunt Galdzicki
Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome.
Nathan Cramer; Zygmunt Galdzicki
From abnormal hippocampal synaptic plasticity in down syndrome mouse models to cognitive disability in down syndrome.
Ranjana Verma; Xiufen Xu; Manoj K Jaiswal; Cara Olsen; David Mears; Giuseppina Caretti; Zygmunt Galdzicki
In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components.

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All Publications

2012: Tyler K Best; Lina Chakrabarti; Nathan P Cramer; Tarik F Haydar; Zygmunt Galdzicki
Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome.
Experimental neurology 2012;233(2):749-57.
2012: Nathan Cramer; Zygmunt Galdzicki
From abnormal hippocampal synaptic plasticity in down syndrome mouse models to cognitive disability in down syndrome.
Neural plasticity 2012;2012():101542.
2011: Ranjana Verma; Xiufen Xu; Manoj K Jaiswal; Cara Olsen; David Mears; Giuseppina Caretti; Zygmunt Galdzicki
In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components.
Toxicology and applied pharmacology 2011;253(3):178-87.
2010: Lina Chakrabarti; Tyler K Best; Nathan P Cramer; Rosalind S E Carney; John T R Isaac; Zygmunt Galdzicki; Tarik F Haydar
Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome.
Nature neuroscience 2010;13(8):927-34.
2010: Nathan P Cramer; Tyler K Best; Marcus Stoffel; Richard J Siarey; Zygmunt Galdzicki
GABAB-GIRK2-mediated signaling in Down syndrome.
Advances in pharmacology (San Diego, Calif.) 2010;58():397-426.
2009: Kwan-Hyuck Baek; Alexander Zaslavsky; Ryan C Lynch; Carmella Britt; Yoshiaki Okada; Richard J Siarey; M William Lensch; In-Hyun Park; Sam S Yoon; Takashi Minami; julie R korenberg; Judah Folkman; George Q Daley; William C Aird; Zygmunt Galdzicki; Sandra W Ryeom
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.
Nature 2009;459(7250):1126-30.
2008: Tyler K Best; Madelaine Cho-Clark; Richard J Siarey; Zygmunt Galdzicki
Speeding of miniature excitatory post-synaptic currents in Ts65Dn cultured hippocampal neurons.
Neuroscience letters 2008;438(3):356-61.
2007: Lina Chakrabarti; Zygmunt Galdzicki; Tarik F Haydar
Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(43):11483-95.
2007: Lisa E Olson; Randall J Roper; Crystal L Sengstaken; Elizabeth A Peterson; Veronica Aquino; Zygmunt Galdzicki; Richard J Siarey; Mikhail V Pletnikov; Timothy H Moran; Roger H Reeves
Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.
Human molecular genetics 2007;16(7):774-82.
2007: Tyler K Best; Richard J Siarey; Zygmunt Galdzicki
Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current.
Journal of neurophysiology 2007;97(1):892-900.
2006: Richard J Siarey; Angelina Kline-Burgess; Madelaine Cho; Andrea Balbo; Tyler K Best; Chie Harashima; Eric Klann; Zygmunt Galdzicki
Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
Journal of neurochemistry 2006;98(4):1266-77.
2006: Chie Harashima; David M Jacobowitz; Markus Stoffel; Lina Chakrabarti; Tarik F Haydar; Richard J Siarey; Zygmunt Galdzicki
Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model.
Cellular and molecular neurobiology 2006;26(4-6):719-34.
2006: Chie Harashima; David M Jacobowitz; Jassir Witta; Rosemary C Borke; Tyler K Best; Richard J Siarey; Zygmunt Galdzicki
Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome.
The Journal of comparative neurology 2006;494(5):815-33.
2005: Richard J Siarey; Angela J Villar; Charles J Epstein; Zygmunt Galdzicki
Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome.
Neuropharmacology 2005;49(1):122-8.
2003: Zygmunt Galdzicki; Richard J Siarey
Understanding mental retardation in Down's syndrome using trisomy 16 mouse models.
Genes, brain, and behavior 2003;2(3):167-78.
2001: RC Klein; SE Warder; Zygmunt Galdzicki; Francis J Castellino; Zhenyu Sheng
Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides.
Neuropharmacology 2001;41(7):801-10.
2001: EG Chikhale; Andrea Balbo; Zygmunt Galdzicki; Stanley I Rapoport; H Umesha Shetty
Measurement of myo-inositol turnover in phosphatidylinositol: description of a model and mass spectrometric method for cultured cortical neurons.
Biochemistry 2001;40(37):11114-20.
2001: RC Klein; Zhenyu Sheng; Zygmunt Galdzicki; Francis J Castellino
The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors.
The Journal of biological chemistry 2001;276(29):26860-7.
2001: Zygmunt Galdzicki; Richard J Siarey; R Pearce; J Stoll; Stanley I Rapoport
On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models.
Brain research. Brain research reviews 2001;35(2):115-45.
2001: RC Klein; Richard J Siarey; A Caruso; Stanley I Rapoport; Francis J Castellino; Zygmunt Galdzicki
Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons.
Journal of neurochemistry 2001;76(6):1663-9.
2000: S Peng; Stanley I Rapoport; R J Pearce; Zygmunt Galdzicki
Abnormal chloride and potassium conductances in cultured embryonic tongue muscle from trisomy 16 mouse.
Brain research. Developmental brain research 2000;122(2):193-7.
2000: H Umesha Shetty; Richard J Siarey; Zygmunt Galdzicki; J Stoll; Stanley I Rapoport
Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues.
Neurochemical research 2000;25(4):431-5.
2000: Wei Huang; Zygmunt Galdzicki; P van Gelderen; Andrea Balbo; EG Chikhale; Mark B Schapiro; Stanley I Rapoport
Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment.
Neuroreport 2000;11(3):445-8.
1999: Richard J Siarey; E J Carlson; Charles J Epstein; Andrea Balbo; Stanley I Rapoport; Zygmunt Galdzicki
Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome.
Neuropharmacology 1999;38(12):1917-20.
1999: RC Klein; Zygmunt Galdzicki; Francis J Castellino
Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons.
Neuropharmacology 1999;38(12):1819-29.
1999: M Scortegagna; Zygmunt Galdzicki; Stanley I Rapoport; Ingeborg Hanbauer
Activator protein-1 DNA binding activation by hydrogen peroxide in neuronal and astrocytic primary cultures of trisomy-16 and diploid mice.
Brain research. Molecular brain research 1999;73(1-2):144-50.
1998: N J Lane; Andrea Balbo; R Fukuyama; Stanley I Rapoport; Zygmunt Galdzicki
The ultrastructural effects of beta-amyloid peptide on cultured PC12 cells: changes in cytoplasmic and intramembranous features.
Journal of neurocytology 1998;27(10):707-18.
1998: Ingeborg Hanbauer; Zygmunt Galdzicki; Stanley I Rapoport; M Scortegagna
Evidence of increased oxidative stress in hippocampal primary cultures of trisomy 16 mouse. Studies on metallothionein-I/II.
Restorative neurology and neuroscience 1998;12(2-3):87-93.
1998: Zygmunt Galdzicki; E J Coan; Stanley I Rapoport; J Stoll
Increased expression of voltage-activated calcium channels in cultured hippocampal neurons from mouse trisomy 16, a model for Down syndrome.
Brain research. Molecular brain research 1998;56(1-2):200-6.
1998: M Scortegagna; Zygmunt Galdzicki; Stanley I Rapoport; Ingeborg Hanbauer
In cortical cultures of trisomy 16 mouse brain the upregulated metallothionein-I/II fails to respond to H2O2 exposure or glutamate receptor stimulation.
Brain research 1998;787(2):292-8.
1997: Richard J Siarey; J Stoll; Stanley I Rapoport; Zygmunt Galdzicki
Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome.
Neuropharmacology 1997;36(11-12):1549-54.
1997: David D Allen; Zygmunt Galdzicki; S K Brining; R Fukuyama; Stanley I Rapoport; Quentin R Smith
Beta-amyloid induced increase in choline flux across PC12 cell membranes.
Neuroscience letters 1997;234(1):71-3.
1997: Richard J Siarey; E J Coan; Stanley I Rapoport; Zygmunt Galdzicki
Responses to NMDA in cultured hippocampal neurons from trisomy 16 embryonic mice.
Neuroscience letters 1997;232(3):131-4.
1997: G Ehrenstein; Zygmunt Galdzicki; G D Lange
The choline-leakage hypothesis for the loss of acetylcholine in Alzheimer's disease.
Biophysical journal 1997;73(3):1276-80.
1996: J Stoll; Zygmunt Galdzicki
Reduced expression of voltage-gated sodium channels in neurons cultured from trisomy 16 mouse hippocampus.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1996;14(6):749-60.
1996: H Umesha Shetty; H W Holloway; L D Acevedo; Zygmunt Galdzicki
Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's syndrome.
The Biochemical journal 1996;313 ( Pt 1)():31-3.
1995: L D Acevedo; Zygmunt Galdzicki; A R McIntosh; Stanley I Rapoport
Increased inward current in septal neurons from the trisomy 16 mouse, a model for Down's syndrome.
Brain research 1995;701(1-2):89-98.
1995: R Pearce; Zygmunt Galdzicki; Stanley I Rapoport
Decreased sensitivity to nerve growth factor of dorsal root ganglion neurons cultured from mouse trisomy 16, a model of Down's syndrome.
Brain research 1995;680(1-2):108-16.
1994: R Fukuyama; K C Wadhwani; Zygmunt Galdzicki; Stanley I Rapoport; G Ehrenstein
beta-Amyloid polypeptide increases calcium-uptake in PC12 cells: a possible mechanism for its cellular toxicity in Alzheimer's disease.
Brain research 1994;667(2):269-72.
1994: E J Coan; Zygmunt Galdzicki; Stanley I Rapoport
Effects of nerve growth factor on whole-cell currents and other electrical membrane properties in cultured dorsal root ganglion neurons from normal and trisomy 16 mice.
Brain research 1994;650(1):161-5.
1994: Zygmunt Galdzicki; R Fukuyama; K C Wadhwani; Stanley I Rapoport; G Ehrenstein
beta-Amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease.
Brain research 1994;646(2):332-6.
1993: Zygmunt Galdzicki; E Coan; Stanley I Rapoport
Cultured hippocampal neurons from trisomy 16 mouse, a model for Down's syndrome, have an abnormal action potential due to a reduced inward sodium current.
Brain research 1993;604(1-2):69-78.