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John Galivan

Research Profile

Chemicals & Drugs

Disorders

Liver Neoplasms, Experimental

Living Beings

Rats

Anatomy

Physiology

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Publications

TOP 3
Karen J Chave; Thomas J Ryan; Stacey E Chmura; John Galivan
Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms.
Dezhong Yin; John Galivan; Wei Ao; Rong Yao
Characterization of the human gamma-glutamyl hydrolase promoter and its gene expression in human tissues and cancer cell lines.
Karen J Chave; I E Auger; John Galivan; Thomas J Ryan
Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase.

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All Publications

2003: Karen J Chave; Thomas J Ryan; Stacey E Chmura; John Galivan
Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms.
Gene 2003;319():167-75.
2003: Dezhong Yin; John Galivan; Wei Ao; Rong Yao
Characterization of the human gamma-glutamyl hydrolase promoter and its gene expression in human tissues and cancer cell lines.
Gene 2003;312():281-8.
2000: Karen J Chave; I E Auger; John Galivan; Thomas J Ryan
Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase.
The Journal of biological chemistry 2000;275(51):40365-70.
2000: John Galivan; Thomas J Ryan; Karen J Chave; M Rhee; Rong Yao; Dezhong Yin
Glutamyl hydrolase. pharmacological role and enzymatic characterization.
Pharmacology & therapeutics 2000;85(3):207-15.
1999: Karen J Chave; John Galivan; Thomas J Ryan
Site-directed mutagenesis establishes cysteine-110 as essential for enzyme activity in human gamma-glutamyl hydrolase.
The Biochemical journal 1999;343 Pt 3():551-5.
1999: Dezhong Yin; Karen J Chave; C R Macaluso; John Galivan; Rong Yao
Structural organization of the human gamma-glutamyl hydrolase gene.
Gene 1999;238(2):463-70.
1999: John Galivan; T Ryan; M Rhee; Rong Yao; Karen J Chave
Glutamyl hydrolase: properties and pharmacologic impact.
Seminars in oncology 1999;26(2 Suppl 6):33-7.
1999: M S Rhee; Thomas J Ryan; John Galivan
Glutamyl hydrolase and the multitargeted antifolate LY231514.
Cancer chemotherapy and pharmacology 1999;44(5):427-32.
1998: T Esaki; K Roy; Rong Yao; John Galivan; Francis M Sirotnak
Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences.
Gene 1998;219(1-2):37-44.
1998: M S Rhee; B Lindau-Shepard; Karen J Chave; John Galivan; Thomas J Ryan
Characterization of human cellular gamma-glutamyl hydrolase.
Molecular pharmacology 1998;53(6):1040-6.
1996: John J McGuire; B P Hart; W H Haile; K J Magee; M Rhee; W E Bolanowska; C Russell; John Galivan; B Paul; James K Coward
Biological properties of fluoroglutamate-containing analogs of folates and methotrexate with altered capacities to form poly (gamma-glutamate) metabolites.
Biochemical pharmacology 1996;52(8):1295-303.
1996: Rong Yao; E Schneider; Thomas J Ryan; John Galivan
Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10134-8.
1996: Rong Yao; Z Nimec; Thomas J Ryan; John Galivan
Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase.
The Journal of biological chemistry 1996;271(15):8525-8.
1996: John J McGuire; Takashi Tsukamoto; B P Hart; James K Coward; T I Kalman; John Galivan
Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy.
Investigational new drugs 1996;14(3):317-23.
1995: John Galivan; M S Rhee
Insulin-dependent suppression in glutamyl hydrolase activity and elevated cellular methotrexate polyglutamates.
Biochemical pharmacology 1995;50(10):1659-63.
1995: R Yao; M S Rhee; John Galivan
Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells.
Molecular pharmacology 1995;48(3):505-11.
1995: John J McGuire; B P Hart; W H Haile; M S Rhee; John Galivan; James K Coward
DL-beta,beta-difluoroglutamic acid mediates position-dependent enhancement or termination of pteroylpoly(gamma-glutamate) synthesis catalyzed by folylpolyglutamate synthetase.
Archives of biochemistry and biophysics 1995;321(2):319-28.
1995: Giuseppe Pizzorno; B A Moroson; A R Cashmore; O Russello; J R Mayer; John Galivan; Marlene A Bunni; David G Priest; G Peter Beardsley
Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.
Cancer research 1995;55(3):566-73.
1994: M S Rhee; John Galivan; J E Wright; Andre Rosowsky
Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
Molecular pharmacology 1994;45(4):783-91.
1994: B M O'Connor; S Webber; R C Jackson; John Galivan; M S Rhee
Biological activity of a novel rationally designed lipophilic thymidylate synthase inhibitor.
Cancer chemotherapy and pharmacology 1994;34(3):225-9.
1993: Y Wang; Z Nimec; T J Ryan; J A Dias; John Galivan
The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells.
Biochimica et biophysica acta 1993;1164(3):227-35.
1993: M S Rhee; Y Wang; M G Nair; John Galivan
Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity.
Cancer research 1993;53(10 Suppl):2227-30.
1993: A Abraham; M G Nair; John J McGuire; John Galivan; Roy L Kisliuk; B R Vishnuvajjala
Antitumor efficacy of classical non-polyglutamylatable antifolates that inhibit dihydrofolate reductase.
Advances in experimental medicine and biology 1993;338():663-6.
1993: Y Wang; R F Rotundo; Z Nimec; T J Ryan; John Galivan
Two novel HPLC methods which rapidly detect the substrates and cleavage products of gamma-glutamyl hydrolase.
Advances in experimental medicine and biology 1993;338():655-8.
1993: M S Rhee; John Galivan; E M Tyobeka; M L Sherman; Andre Rosowsky
Effect of a novel antifolate, N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523), on growth of H35 rat hepatoma and HEPG2 human hepatoma cells.
Advances in experimental medicine and biology 1993;338():461-4.
1993: A Abraham; John J McGuire; John Galivan; B R Vishnuvajjala; M G Nair
New thiophene substituted 10-deazaaminopterins: synthesis and biological evaluation.
Advances in experimental medicine and biology 1993;338():421-4.
1993: Y Wang; J A Dias; Z Nimec; R Rotundo; B M O'Connor; J Freisheim; John Galivan
The properties and function of gamma-glutamyl hydrolase and poly-gamma-glutamate.
Advances in enzyme regulation 1993;33():207-18.
1992: M S Rhee; James K Coward; John Galivan
Depletion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate by methotrexate in cultured hepatoma cells.
Molecular pharmacology 1992;42(5):909-16.
1992: Andre Rosowsky; John Galivan; G Peter Beardsley; H Bader; B M O'Connor; O Russello; B A Moroson; M T DeYarman; S S Kerwar; J H Freisheim
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Cancer research 1992;52(8):2148-55.
1992: James R Piper; N D Malik; M S Rhee; John Galivan; Francis M Sirotnak
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
Journal of medicinal chemistry 1992;35(2):332-7.
1991: B M O'Connor; R F Rotundo; Z Nimec; John J McGuire; John Galivan
Secretion of gamma-glutamyl hydrolase in vitro.
Cancer research 1991;51(15):3874-81.
1991: A Abraham; John J McGuire; John Galivan; Z Nimec; Roy L Kisliuk; Y Gaumont; M G Nair
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
Journal of medicinal chemistry 1991;34(1):222-7.
1991: M Balinska; M Rhee; J M Whiteley; David G Priest; John Galivan
Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate.
Archives of biochemistry and biophysics 1991;284(1):219-22.
1991: John Galivan; M Rhee; David G Priest; Marlene A Bunni; J H Freisheim; J M Whiteley
The effect of methotrexate on the folate coenzyme pools in human hepatoma cells in culture.
Advances in experimental medicine and biology 1991;309A():75-8.
1990: M S Rhee; M Balinska; Marlene A Bunni; David G Priest; Gladys F Maley; Frank Maley; John Galivan
Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells.
Cancer research 1990;50(13):3979-84.
1990: N J Licato; James K Coward; Z Nimec; John Galivan; W E Bolanowska; John J McGuire
Synthesis of N-[N-(4-deoxy-4-amino-10-methylpteroyl)-4-fluoroglutamyl]- gamma-glutamate, an unusual substrate for folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase.
Journal of medicinal chemistry 1990;33(3):1022-7.
1990: A Abraham; M G Nair; Roy L Kisliuk; Y Gaumont; John Galivan
Folate analogues. 33. Synthesis of folate and antifolate poly-gamma-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cells.
Journal of medicinal chemistry 1990;33(2):711-7.
1989: John J McGuire; M Graber; N Licato; Claudius Vincenz; James K Coward; Z Nimec; John Galivan
Biochemical and growth inhibitory effects of the erythro and threo isomers of gamma-fluoromethotrexate, a methotrexate analogue defective in polyglutamylation.
Cancer research 1989;49(16):4517-25.
1989: John Galivan; M S Rhee; T B Johnson; R Dilwith; M G Nair; Marlene A Bunni; David G Priest
The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
The Journal of biological chemistry 1989;264(18):10685-92.
1989: S D Patil; C Jones; M G Nair; John Galivan; F Maley; Roy L Kisliuk; Y Gaumont; D Duch; R Ferone
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.
Journal of medicinal chemistry 1989;32(6):1284-9.
1989: M S Rhee; T B Johnson; David G Priest; John Galivan
The effect of methionine on methotrexate metabolism in rat hepatocytes in monolayer culture.
Biochimica et biophysica acta 1989;1011(2-3):122-8.
1989: John Galivan; Z Nimec; R Rotundo
The characteristics and consequences of folate depletion in hepatoma cells in vitro by inhibition of dihydrofolate reductase.
Advances in enzyme regulation 1989;29():209-17.
1989: John Galivan; M S Rhee; T B Johnson; T C Chou; M G Nair; Marlene A Bunni; David G Priest
The enhancement of the activity of 10-propargyl-5,8-dideazafolate and 5,10-dideazatetrahydrofolate by inhibitors of dihydrofolate reductase.
Advances in enzyme regulation 1989;28():13-21.
1989: K Ferguson; D Boschelli; P Hoffman; ARNOLD ORONSKY; J Whiteley; S Webber; John Galivan; J Freishiem; J Hynes; S S Kerwar
Synergy between 5,10-dideaza-5,6,7,8-tetrahydrofolic acid and methotrexate in mice bearing L1210 tumors.
Cancer chemotherapy and pharmacology 1989;25(3):173-6.
1988: Francis M Sirotnak; T B Johnson; L L Samuels; John Galivan
Proliferation-dependency of folylpolyglutamyl synthetase activity in maturating luminal epithelial cells of mouse small intestine.
Biochemical pharmacology 1988;37(21):4239-41.
1988: L S Trivedi; M Rhee; John Galivan; Michael J Fasco
Normal and warfarin-resistant rat hepatocyte metabolism of vitamin K 2,3-epoxide: evidence for multiple pathways of hydroxyvitamin K formation.
Archives of biochemistry and biophysics 1988;264(1):67-73.
1988: John Galivan; Z Nimec; M Rhee; D Boschelli; ARNOLD ORONSKY; S S Kerwar
Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
Cancer research 1988;48(9):2421-5.
1988: T B Johnson; M G Nair; John Galivan
Role of folylpolyglutamate synthetase in the regulation of methotrexate polyglutamate formation in H35 hepatoma cells.
Cancer research 1988;48(9):2426-31.
1987: C Kruger-McDermott; T B Johnson; Robert Rej; T vanderHoeven; M G Nair; John Galivan
The absence of gamma-glutamyltransferase activity in transport-dependent methotrexate-resistant hepatoma cells.
International journal of cancer. Journal international du cancer 1987;40(6):835-9.
1987: John Galivan; Z Nimec; M Rhee
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Cancer research 1987;47(20):5256-60.
1987: John Galivan; T Johnson; M Rhee; John J McGuire; David G Priest; V Kesevan
The role of folylpolyglutamate synthetase and gamma-glutamyl hydrolase in altering cellular folyl- and antifolylpolyglutamates.
Advances in enzyme regulation 1987;26():147-55.
1987: John J McGuire; James R Piper; J K Coward; John Galivan
Folate analog nonsubstrates and inhibitors of folylpolyglutamate synthetase as potential cancer chemotherapy drugs.
NCI monographs : a publication of the National Cancer Institute 1987;(5):139-44.
1986: C Kruger-McDermott; M Balinska; John Galivan
Dihydrofolate-mediated reversal of methotrexate toxicity to hepatoma cells in vitro.
Cancer letters 1986;30(1):79-84.
1985: John Galivan; James Inglese; John J McGuire; Z Nimec; James K Coward
gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(9):2598-602.
1985: John Galivan; Z Nimec; James K Coward; John J McGuire
Glutamylation of methotrexate in hepatoma cells in vitro: regulation and the development of specific inhibitors.
Advances in enzyme regulation 1985;23():13-23.
1983: John Galivan; Z Nimec; M Balinska
Regulation of methotrexate polyglutamate accumulation in vitro: effects of cellular folate content.
Biochemical pharmacology 1983;32(21):3244-7.
1983: Z Nimec; John Galivan
Regulatory aspects of the glutamylation of methotrexate in cultured hepatoma cells.
Archives of biochemistry and biophysics 1983;226(2):671-80.
1983: John Galivan; Z Nimec
Effects of folinic acid on hepatoma cells containing methotrexate polyglutamates.
Cancer research 1983;43(2):551-5.
1983: John Galivan; M Balinska
Studies of formation and efflux of methotrexate polyglutamates with cultured hepatic cells.
Advances in experimental medicine and biology 1983;163():235-46.
1982: M Balinska; W A Samsonoff; John Galivan
Reversibly permeable hepatoma cells in culture.
Biochimica et biophysica acta 1982;721(3):253-61.
1982: John Galivan; M Balińska; J M Whiteley
Interaction of methotrexate poly(L-lysine) with transformed hepatic cells in culture.
Archives of biochemistry and biophysics 1982;216(2):544-50.
1982: M Balinska; Z Nimec; John Galivan
Characteristics of methotrexate polyglutamate formation in cultured hepatic cells.
Archives of biochemistry and biophysics 1982;216(2):466-76.
1982: John Galivan; M Balinska; Z Nimec; M P Fox
Factors controlling the concentrations of methotrexate in cultured hepatic cells.
Advances in enzyme regulation 1982;20():111-21.
1981: M Balińska; John Galivan; J K Coward
Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro.
Cancer research 1981;41(7):2751-6.
1981: J M Whiteley; Z Nimec; John Galivan
Treatment of Reuber H35 hepatoma cells with carrier-bound methotrexate.
Molecular pharmacology 1981;19(3):505-8.
1980: John Galivan; A Tarentino; W Samsonoff
Membrane characteristics of primary hepatocyte cultures and a stable hepatocarcinoma cell line.
Annals of the New York Academy of Sciences 1980;349():332-45.