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Gonçalo Gamboa da Costa

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Igor P Pogribny; Svitlana Shpyleva; Gordon Surratt; Volodymyr Tryndyak; Gonçalo Gamboa da Costa; Marta Pogribna; Frederick A Beland
Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.
Omari Bandele; Thomas Black; Luísa Camacho; Martine Ferguson; Gonçalo Gamboa da Costa; Zachary Keltner; Nicholas Olejnik; renate reimschuessel; Michael Scott; Cynthia Stine; Robert L Sprando
Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure.
Robert L Sprando; Cynthia B Stine; Andriy Tkachenko; Kellie Woodling; Omari Bandele; Thomas Black; Tina Crosby; Eric Evans; Martine Ferguson; Zachary Keltner; Lucie Loukotková; Sarah M Nemser; Nicholas Olejnik; renate reimschuessel; Michael Scott; Gonçalo Gamboa da Costa
Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: gavage vs. feeding.

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2013: Igor P Pogribny; Svitlana Shpyleva; Gordon Surratt; Volodymyr Tryndyak; Gonçalo Gamboa da Costa; Marta Pogribna; Frederick A Beland
Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.
International journal of oncology 2013;42(5):1822-32.
2013: Omari Bandele; Thomas Black; Luísa Camacho; Martine Ferguson; Gonçalo Gamboa da Costa; Zachary Keltner; Nicholas Olejnik; renate reimschuessel; Michael Scott; Cynthia Stine; Robert L Sprando
Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013;51():106-13.
2012: Robert L Sprando; Cynthia B Stine; Andriy Tkachenko; Kellie Woodling; Omari Bandele; Thomas Black; Tina Crosby; Eric Evans; Martine Ferguson; Zachary Keltner; Lucie Loukotková; Sarah M Nemser; Nicholas Olejnik; renate reimschuessel; Michael Scott; Gonçalo Gamboa da Costa
Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: gavage vs. feeding.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(12):4389-97.
2012: Laura K Schnackenberg; Jinchun Sun; Sudeepa Bhattacharyya; Gonçalo Gamboa da Costa; Lisa M Pence; Richard Beger
Metabolomics evaluation of hydroxyproline as a potential marker of melamine and cyanuric acid nephrotoxicity in male and female Fischer F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(11):3978-83.
2012: Linda S Von Tungeln; William M Witt; Daniel R Doerge; Gonçalo Gamboa da Costa; Igor Koturbash; M Matilde Marques; Igor P Pogribny; Frederick A Beland
Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.
International journal of cancer. Journal international du cancer 2012;131(9):2008-15.
2012: Yuewei Zhao; Lining Cai; Gonçalo Gamboa da Costa; Qingsu Xia; Hongtao Yu; Peter P Fu
Full structure assignments of pyrrolizidine alkaloid DNA adducts and mechanism of tumor initiation.
Chemical research in toxicology 2012;25(9):1985-96.
2012: Qin Zhang; Ronald P Brown; Gonçalo Gamboa da Costa; Cristina C Jacob; Linda S Von Tungeln; Peter L Goering
Urinary biomarker detection of melamine- and cyanuric acid-induced kidney injury in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2012;129(1):1-8.
2012: Gonçalo Gamboa da Costa; Nicholas R Hasbrouck; David G Hattan; Cristina C Jacob; Greg R Olson; renate reimschuessel; Linda S Von Tungeln; Frederick A Beland
Dose-response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats.
Toxicology and applied pharmacology 2012;262(2):99-106.
2012: Cristina C Jacob; Michelle Vanlandingham; Linda S Von Tungeln; Frederick A Beland; Gonçalo Gamboa da Costa
Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):317-24.
2011: Volker M Arlt; James D Evans; Peter B Farmer; Eva Frei; Gonçalo Gamboa da Costa; Colin J Henderson; Rajinder Singh; Marie Stiborová; C Roland Wolf; David H Phillips
Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2169-73.
2011: Luísa Camacho; Frederick A Beland; Kevin P Kelly; Gonçalo Gamboa da Costa
Gene expression of biomarkers of nephrotoxicity in F344 rats co-exposed to melamine and cyanuric acid for seven days.
Toxicology letters 2011;206(2):166-71.
2011: Cynthia B Stine; Elizabeth Tall; Gonçalo Gamboa da Costa; Jamie Boehmer; Eric R Evans; Charlie Gieseker; Nicholas R Hasbrouck; Tamara D Mayer; renate reimschuessel; Jeffrey L Ward
A No Observable Adverse Effects Level (NOAEL) for pigs fed melamine and cyanuric acid.
Regulatory toxicology and pharmacology : RTP 2011;60(3):363-72.
2011: Cristina C Jacob; Gonçalo Gamboa da Costa
Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(9-10):652-6.
2011: Cristina C Jacob; renate reimschuessel; Linda S Von Tungeln; Greg R Olson; Alan Warbritton; David G Hattan; Frederick A Beland; Gonçalo Gamboa da Costa
Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(2):391-7.
2010: Rajinder Singh; Volker M Arlt; Colin Henderson; David H Phillips; Peter B Farmer; Gonçalo Gamboa da Costa
Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(23):2155-62.
2010: Peter P Fu; Ming W Chou; Mona I Churchwell; Yuping Wang; Yuewei Zhao; Qingsu Xia; Gonçalo Gamboa da Costa; M Matilde Marques; Frederick A Beland; Daniel R Doerge
High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo.
Chemical research in toxicology 2010;23(3):637-52.
2009: Fatemeh Rafii; Miseon Park; Gonçalo Gamboa da Costa; Luisa Camacho
Comparison of the metabolic activities of four wild-type Clostridium perfringens strains with their gatifloxacin-selected resistant mutants.
Archives of microbiology 2009;191(12):895-902.
2009: Gonçalo Gamboa da Costa; Rajinder Singh; Volker M Arlt; Amin Mirza; Meirion Richards; Takeji Takamura-Enya; Heinz H Schmeiser; Peter B Farmer; David H Phillips
Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry.
Chemical research in toxicology 2009;22(11):1860-8.
2009: Eden Tareke; Thomas M Heinze; Gonçalo Gamboa da Costa; Syed Ali
Acrylamide formed at physiological temperature as a result of asparagine oxidation.
Journal of agricultural and food chemistry 2009;57(20):9730-3.
2008: Jóhannes Reynisson; Marie Stiborová; Václav Martínek; Gonçalo Gamboa da Costa; David H Phillips; Volker M Arlt
Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment.
Environmental and molecular mutagenesis 2008;49(8):659-67.
2008: Volker M Arlt; Marie Stiborová; Colin Henderson; Markus Thiemann; Eva Frei; Dagmar Aimová; Rajinder Singh; Gonçalo Gamboa da Costa; Oliver J Schmitz; Peter B Farmer; C Roland Wolf; David H Phillips
Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.
Carcinogenesis 2008;29(3):656-65.
2007: Gonçalo Gamboa da Costa; M Matilde Marques; Xin Fu; Mona I Churchwell; Yu-Ping Wang; Daniel R Doerge; Frederick A Beland
Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen.
Cancer letters 2007;257(2):191-8.
2007: Volker M Arlt; Hansruedi Glatt; Gonçalo Gamboa da Costa; Jóhannes Reynisson; Takeji Takamura-Enya; David H Phillips
Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(2):445-57.
2007: Célia Martins; Nuno G Oliveira; Marta Pingarilho; Gonçalo Gamboa da Costa; Vanda Martins; M Matilde Marques; Frederick A Beland; Mona I Churchwell; Daniel R Doerge; Jose Rueff; Jorge Gaspar
Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adducts.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(2):383-90.
2005: Frederick A Beland; M Matilde Marques; Gonçalo Gamboa da Costa; David H Phillips
Tamoxifen-DNA adduct formation in human endometrium.
Chemical research in toxicology 2005;18(10):1507-9; author reply 1509-11.
2004: Dean W Roberts; Daniel R Doerge; Mona I Churchwell; Gonçalo Gamboa da Costa; M Matilde Marques; William H Tolleson
Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover).
Journal of agricultural and food chemistry 2004;52(21):6623-32.
2004: Frederick A Beland; Mona I Churchwell; Daniel R Doerge; Daniel R Parkin; Danuta Malejka-Giganti; Alan Hewer; David H Phillips; Carmichael Paul; Gonçalo Gamboa da Costa; M Matilde Marques
Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans.
Journal of the National Cancer Institute 2004;96(14):1099-104.
2004: Nathan C Twaddle; L Patrice McDaniel; Gonçalo Gamboa da Costa; Mona I Churchwell; Frederick A Beland; Daniel R Doerge
Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC-ES/MS/MS.
Cancer letters 2004;207(1):9-17.
2003: Gonçalo Gamboa da Costa; Mona I Churchwell; L Patrice Hamilton; Linda S Von Tungeln; Frederick A Beland; M Matilde Marques; Daniel R Doerge
DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.
Chemical research in toxicology 2003;16(10):1328-37.
2003: Laura J Schild; Rao L Divi; Frederick A Beland; Mona I Churchwell; Daniel R Doerge; Gonçalo Gamboa da Costa; M Matilde Marques; Miriam C Poirier
Formation of tamoxifen-DNA adducts in multiple organs of adult female cynomolgus monkeys dosed with tamoxifen for 30 days.
Cancer research 2003;63(18):5999-6003.
2003: Gonçalo Gamboa da Costa; M Matilde Marques; James P Freeman; Frederick A Beland
Synthesis and investigation of alpha-hydroxy-N,N-didesmethyltamoxifen as a proximate carcinogen in the metabolic activation of tamoxifen.
Chemical research in toxicology 2003;16(9):1090-8.
2003: Gonçalo Gamboa da Costa; M Matilde Marques; Frederick A Beland; James P Freeman; Mona I Churchwell; Daniel R Doerge
Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry.
Chemical research in toxicology 2003;16(3):357-66.
2002: Tao Chen; Gonçalo Gamboa da Costa; M Matilde Marques; Sharon D Shelton; Frederick A Beland; Mugimane G Manjanatha
Mutations induced by alpha-hydroxytamoxifen in the lacI and cII genes of Big Blue transgenic rats.
Carcinogenesis 2002;23(10):1751-7.
2002: M Matilde Marques; Gonçalo Gamboa da Costa; Lonnie R Blankenship; Sandra J Culp; Frederick A Beland
The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline.
Mutation research 2002;506-507():41-8.
2000: Gonçalo Gamboa da Costa; L Patrice Hamilton; Frederick A Beland; M Matilde Marques
Characterization of the major DNA adduct formed by alpha-hydroxy-N-desmethyltamoxifen in vitro and in vivo.
Chemical research in toxicology 2000;13(3):200-7.