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Dora Games

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Wagner Zago; Christopher Nishioka; Dale Schenk; Peter Seubert; Frédérique Bard; Manuel Buttini; Thomas A Comery; Dora Games; Shyra J Gardai; Gene G Kinney
Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.
Eliezer Masliah; Edward Rockenstein; Michael Mante; Leslie Crews; Brian Spencer; Anthony Adame; Christina Patrick; Margarita Trejo; Kiren Ubhi; Troy T Rohn; Sarah Mueller-Steiner; Peter Seubert; Robin Barbour; Lisa McConlogue; Manuel Buttini; Dora Games; Dale Schenk
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.
Stephanie Daumas; Johan Sandin; Karen S Chen; Dione Kobayashi; Jane Tulloch; Stephen J Martin; Dora Games; Richard G M Morris
Faster forgetting contributes to impaired spatial memory in the PDAPP mouse: deficit in memory retrieval associated with increased sensitivity to interference?

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2012: Wagner Zago; Christopher Nishioka; Dale Schenk; Peter Seubert; Frédérique Bard; Manuel Buttini; Thomas A Comery; Dora Games; Shyra J Gardai; Gene G Kinney
Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(8):2696-702.
2011: Eliezer Masliah; Edward Rockenstein; Michael Mante; Leslie Crews; Brian Spencer; Anthony Adame; Christina Patrick; Margarita Trejo; Kiren Ubhi; Troy T Rohn; Sarah Mueller-Steiner; Peter Seubert; Robin Barbour; Lisa McConlogue; Manuel Buttini; Dora Games; Dale Schenk
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.
PloS one 2011;6(4):e19338.
2008: Stephanie Daumas; Johan Sandin; Karen S Chen; Dione Kobayashi; Jane Tulloch; Stephen J Martin; Dora Games; Richard G M Morris
Faster forgetting contributes to impaired spatial memory in the PDAPP mouse: deficit in memory retrieval associated with increased sensitivity to interference?
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(9):625-32.
2008: Sally Schroeter; Karen Khan; Robin Barbour; Minhtam Doan; Ming Chen; Terry Guido; Davinder Gill; Guriqbal Basi; Dale Schenk; Peter Seubert; Dora Games
Immunotherapy reduces vascular amyloid-beta in PDAPP mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(27):6787-93.
2008: Peter Seubert; Robin Barbour; Karen Khan; Ruth Motter; Pearl Tang; Dora Kholodenko; Kristin Kling; Dale Schenk; Kelly Johnson-Wood; Sally Schroeter; Davinder Gill; J Steven Jacobsen; Menelas Pangalos; Guriqbal S Basi; Dora Games
Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse.
Neuro-degenerative diseases 2008;5(2):65-71.
2007: Lisa McConlogue; Manuel Buttini; John P Anderson; Elizabeth F Brigham; Karen S Chen; Stephen B Freedman; Dora Games; Kelly Johnson-Wood; Michael Lee; Michelle Zeller; Weiqun Liu; Ruth Motter; Sukanto Sinha
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.
The Journal of biological chemistry 2007;282(36):26326-34.
2007: Guiquan Chen; Karen S Chen; Dione Kobayashi; Robin Barbour; Ruth Motter; Dora Games; Stephen J Martin; Richard G M Morris
Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(10):2654-62.
2006: Nicoll James; Edward Barton; Delphine Boche; Jim W Neal; Isidro Ferrer; Petrina Thompson; Christina Vlachouli; David Wilkinson; Antony Bayer; Dora Games; Peter Seubert; Dale Schenk; Clive Holmes
Abeta species removal after abeta42 immunization.
Journal of neuropathology and experimental neurology 2006;65(11):1040-8.
2006: Marion Buckwalter; Bronwen S Coleman; Manuel Buttini; Robin Barbour; Dale Schenk; Dora Games; Peter Seubert; Tony Wyss-Coray
Increased T cell recruitment to the CNS after amyloid beta 1-42 immunization in Alzheimer's mice overproducing transforming growth factor-beta 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(44):11437-41.
2006: Michael H Donovan; Umar Yazdani; Rebekah D Norris; Dora Games; Dwight C German; Amelia J Eisch
Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease.
The Journal of comparative neurology 2006;495(1):70-83.
2006: Dora Games; Manuel Buttini; Dione Kobayashi; Dale Schenk; Peter Seubert
Mice as models: transgenic approaches and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):133-49.
2005: Dwight C German; Omar Nelson; Fen Liang; Chang-Lin Liang; Dora Games
The PDAPP mouse model of Alzheimer's disease: locus coeruleus neuronal shrinkage.
The Journal of comparative neurology 2005;492(4):469-76.
2005: Chera Esh; Lyle Patton; Walter Kalback; Tyler A Kokjohn; John Lopez; Daniel C Brune; Amanda Newell; Thomas Beach; Dale Schenk; Dora Games; Steven Paul; Kelly Bales; Bernardino Ghetti; Eduardo M Castaño; Alex Roher
Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides.
Biochemistry 2005;44(42):13807-19.
2005: Manuel Buttini; Eliezer Masliah; Robin Barbour; Henry Grajeda; Ruth Motter; Kelly Johnson-Wood; Karen Khan; Peter Seubert; Stephen Freedman; Dale Schenk; Dora Games
Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(40):9096-101.
2005: Eliezer Masliah; Edward Rockenstein; Anthony Adame; Michael Alford; Leslie Crews; Makoto Hashimoto; Peter Seubert; Michael Lee; Jason Goldstein; Tamie J Chilcote; Dora Games; Dale Schenk
Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease.
Neuron 2005;46(6):857-68.
2005: Eliezer Masliah; Lawrence A Hansen; Anthony Adame; Leslie Crews; Frédérique Bard; C Lee; Peter Seubert; Dora Games; L Kirby; Dale Schenk
Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease.
Neurology 2005;64(1):129-31.
2004: Thierry Bussière; Frédérique Bard; Robin Barbour; Henry Grajeda; Terry Guido; Karen Khan; Dale Schenk; Dora Games; Peter Seubert; Manuel Buttini
Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.
The American journal of pathology 2004;165(3):987-95.
2004: Chi-Cheng Wu; Faisal Chawla; Dora Games; Russell E Rydel; Stephen Freedman; Dale Schenk; Warren G Young; John H Morrison; Floyd E Bloom
Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7141-6.
2003: Dwight C German; Umar Yazdani; Samuel G Speciale; Parichehr Pasbakhsh; Dora Games; Chang-Lin Liang
Cholinergic neuropathology in a mouse model of Alzheimer's disease.
The Journal of comparative neurology 2003;462(4):371-81.
2003: John F Reilly; Dora Games; Russell E Rydel; Stephen Freedman; Dale Schenk; Warren G Young; John H Morrison; Floyd E Bloom
Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4837-42.
2003: Frédérique Bard; Robin Barbour; Catherine Cannon; Robert Carretto; Michael Fox; Dora Games; Terry Guido; Kathleen Hoenow; Kang Hu; Kelly Johnson-Wood; Karen Khan; Dora Kholodenko; Celeste Lee; Mike Lee; Ruth Motter; Minh Nguyen; Amanda Reed; Dale Schenk; Pearl Tang; Nicki Vasquez; Peter Seubert; Ted Yednock
Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):2023-8.
2003: Jeffrey M Redwine; Barry E Kosofsky; Russell E Jacobs; Dora Games; John F Reilly; John H Morrison; Warren G Young; Floyd E Bloom
Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1381-6.
2002: Brian J Bacskai; Stephen T Kajdasz; Megan E McLellan; Dora Games; Peter Seubert; Dale Schenk; Bradley T Hyman
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7873-8.
2002: Manuel Sánchez-Alavez; Roger A Gallegos; Mary A Kalafut; Dora Games; Steven J Henriksen; José R Criado
Loss of medial septal modulation of dentate gyrus physiology in young mice overexpressing human beta-amyloid precursor protein.
Neuroscience letters 2002;330(1):45-8.
2002: Salvador Huitrón-Reséndiz; Manuel Sánchez-Alavez; Roger A Gallegos; Greta Berg; Elena Crawford; Jeannie L Giacchino; Dora Games; Steven J Henriksen; José R Criado
Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice.
Brain research 2002;928(1-2):126-37.
2001: Elizabeth A Thomas; Lauren N Sautkulis; José R Criado; Dora Games; J Gregor Sutcliffe
Apolipoprotein D mRNA expression is elevated in PDAPP transgenic mice.
Journal of neurochemistry 2001;79(5):1059-64.
2001: Dale Schenk; Dora Games; Peter Seubert
Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization.
Journal of molecular neuroscience : MN 2001;17(2):259-67.
2001: Nagahisa Oshima; Maho Morishima-Kawashima; Haruyasu Yamaguchi; M Yoshimura; S Sugihara; K Khan; Dora Games; Dale Schenk; Yasuo Ihara
Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain.
The American journal of pathology 2001;158(6):2209-18.
2001: Eliezer Masliah; Abbyann Sisk; Margaret Mallory; Dora Games
Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
Journal of neuropathology and experimental neurology 2001;60(4):357-68.
2001: Brian J Bacskai; Stephen T Kajdasz; Richard Christie; C Carter; Dora Games; Peter Seubert; Dale Schenk; Bradley T Hyman
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.
Nature medicine 2001;7(3):369-72.
2000: G Chen; Karen S Chen; J Knox; J Inglis; A Bernard; S J Martin; A Justice; Lisa McConlogue; Dora Games; S B Freedman; Richard G M Morris
A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease.
Nature 2000;408(6815):975-9.
2000: Jeannie L Giacchino; José R Criado; Dora Games; Steven J Henriksen
In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice.
Brain research 2000;876(1-2):185-90.
2000: Frédérique Bard; C Cannon; Robin Barbour; R L Burke; Dora Games; Henry Grajeda; Terry Guido; Kang Hu; Jiping Huang; Kelly Johnson-Wood; Karen Khan; Dora Kholodenko; Mike Lee; I Lieberburg; Ruth Motter; M Nguyen; F Soriano; Nicki Vasquez; K Weiss; B Welch; Peter Seubert; Dale Schenk; Ted Yednock
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease.
Nature medicine 2000;6(8):916-9.
2000: Dora Games; Frédérique Bard; Henry Grajeda; Terry Guido; K Khan; F Soriano; Nicki Vasquez; N Wehner; Kelly Johnson-Wood; Ted Yednock; Peter Seubert; Dale Schenk
Prevention and reduction of AD-type pathology in PDAPP mice immunized with A beta 1-42.
Annals of the New York Academy of Sciences 2000;920():274-84.
1999: John Larson; Gary Lynch; Dora Games; Peter Seubert
Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice.
Brain research 1999;840(1-2):23-35.
1999: Dale Schenk; Robin Barbour; W Dunn; Grace Gordon; Henry Grajeda; Terry Guido; Kang Hu; Jiping Huang; Kelly Johnson-Wood; Karen Khan; Dora Kholodenko; Mike Lee; Z Liao; I Lieberburg; Ruth Motter; L Mutter; F Soriano; G Shopp; Nicki Vasquez; C Vandevert; S Walker; Mark Wogulis; Ted Yednock; Dora Games; Peter Seubert
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Nature 1999;400(6740):173-7.
1999: M Enya; Maho Morishima-Kawashima; M Yoshimura; Y Shinkai; K Kusui; K Khan; Dora Games; Dale Schenk; S Sugihara; Haruyasu Yamaguchi; Yasuo Ihara
Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging.
The American journal of pathology 1999;154(1):271-9.
1998: Karen S Chen; Eliezer Masliah; Henry Grajeda; Terry Guido; Jiping Huang; Karen Khan; Ruth Motter; F Soriano; Dora Games
Neurodegenerative Alzheimer-like pathology in PDAPP 717V-->F transgenic mice.
Progress in brain research 1998;117():327-34.
1997: Michael C Irizarry; F Soriano; M McNamara; K J Page; Dale Schenk; Dora Games; Bradley T Hyman
Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):7053-9.
1997: Kelly Johnson-Wood; Mike Lee; Ruth Motter; Kang Hu; Grace Gordon; Robin Barbour; Karen Khan; M Gordon; H Tan; Dora Games; I Lieberburg; Dale Schenk; Peter Seubert; Lisa McConlogue
Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1550-5.
1996: Eliezer Masliah; Abbyann Sisk; Margaret Mallory; Lennart Mucke; Dale Schenk; Dora Games
Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(18):5795-811.
1995: Dora Games; D Adams; R Alessandrini; Robin Barbour; P Berthelette; C Blackwell; T Carr; J Clemens; T Donaldson; F Gillespie
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
Nature 1995;373(6514):523-7.
1992: Dora Games; K M Khan; F Soriano; P S Keim; D L Davis; K Bryant; I Lieberburg
Lack of Alzheimer pathology after beta-amyloid protein injections in rat brain.
Neurobiology of aging 1992;13(5):569-76.