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Hans-Jürgen Apell

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Andreas Fibich; Hans-Jürgen Apell
Kinetics of luminal proton binding to the SR Ca-ATPase.
Erica Cirri; Haim Garty; Steven J D Karlish; Adriana Katz; Yael Lifshitz; Neeraj Kumar Mishra; Talya Belogus; Hans-Jürgen Apell
Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions.
Hans-Jürgen Apell; Gabriela Benz; Daniel Sauerbrunn
Proton diet for the sodium pump.

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All Publications

2011: Andreas Fibich; Hans-Jürgen Apell
Kinetics of luminal proton binding to the SR Ca-ATPase.
Biophysical journal 2011;101(8):1896-904.
2011: Erica Cirri; Haim Garty; Steven J D Karlish; Adriana Katz; Yael Lifshitz; Neeraj Kumar Mishra; Talya Belogus; Hans-Jürgen Apell
Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions.
Biochemistry 2011;50(18):3736-48.
2011: Hans-Jürgen Apell; Gabriela Benz; Daniel Sauerbrunn
Proton diet for the sodium pump.
Biochemistry 2011;50(3):409-18.
2011: Sian L Myers; Flemming Cornelius; Hans-Jürgen Apell; Ronald J Clarke
Kinetics of K(+) occlusion by the phosphoenzyme of the Na(+),K(+)-ATPase.
Biophysical journal 2011;100(1):70-9.
2010: Annabell Witzke; Kathrin Lindner; Keith Munson; Hans-Jürgen Apell
Inhibition of the gastric H,K-ATPase by clotrimazole.
Biochemistry 2010;49(21):4524-32.
2010: Mohammed Khalid; Gaëlle Fouassier; Hans-Jürgen Apell; Flemming Cornelius; Ronald J Clarke
Interaction of ATP with the phosphoenzyme of the Na+,K+-ATPase.
Biochemistry 2010;49(6):1248-58.
2009: Michael Habeck; Erica Cirri; Adriana Katz; Steven J D Karlish; Hans-Jürgen Apell
Investigation of electrogenic partial reactions in detergent-solubilized Na,K-ATPase.
Biochemistry 2009;48(38):9147-55.
2008: Anne Pilotelle-Bunner; Jacqueline M Matthews; Flemming Cornelius; Hans-Jürgen Apell; Pierre Sebban; Ronald J Clarke
ATP binding equilibria of the Na(+),K(+)-ATPase.
Biochemistry 2008;47(49):13103-14.
2008: Gianluca Bartolommei; Nadège Devaux; Francesco Tadini Buoninsegni; Mariarosa Moncelli; Hans-Jürgen Apell
Effect of clotrimazole on the pump cycle of the Na,K-ATPase.
Biophysical journal 2008;95(4):1813-25.
2007: Andreas Fibich; Karl Janko; Hans-Jürgen Apell
Kinetics of proton binding to the sarcoplasmic reticulum Ca-ATPase in the E1 state.
Biophysical journal 2007;93(9):3092-104.
2007: Ronald J Clarke; Hans-Jürgen Apell; Benjamin Y Kong
Allosteric effect of ATP on Na(+),K(+)-ATPase conformational kinetics.
Biochemistry 2007;46(23):7034-44.
2007: Baladhandapani Shanmugavadivu; Hans-Jürgen Apell; Thomas Meins; Kornelius Zeth; Jörg H Kleinschmidt
Correct folding of the beta-barrel of the human membrane protein VDAC requires a lipid bilayer.
Journal of molecular biology 2007;368(1):66-78.
2006: Cosmin L Pocanschi; Tassadite Dahmane; Yann Gohon; Fabrice Rappaport; Hans-Jürgen Apell; Jörg H Kleinschmidt; Jean-Luc Popot
Amphipathic polymers: tools to fold integral membrane proteins to their active form.
Biochemistry 2006;45(47):13954-61.
2006: Nadine Harmel; Hans-Jürgen Apell
Palytoxin-induced effects on partial reactions of the Na,K-ATPase.
The Journal of general physiology 2006;128(1):103-18.
2006: Steve Amoroso; Vanessa V Agon; Thomas Starke-Peterkovic; Malcolm D McLeod; Hans-Jürgen Apell; Pierre Sebban; Ronald J Clarke
Photochemical behavior and Na+,K+-ATPase sensitivity of voltage-sensitive styrylpyridinium fluorescent membrane probes.
Photochemistry and photobiology 2006;82(2):495-502.
2006: Artem G Ayuyan; Valerij S Sokolov; Alexander A Lenz; Hans-Jürgen Apell
Effect of chaotropic anions on the sodium transport by the Na,K-ATPase.
European biophysics journal : EBJ 2006;35(3):247-54.
2006: Cosmin L Pocanschi; Hans-Jürgen Apell; Pål Puntervoll; Bente T Høgh; Harald B Jensen; Wolfram Welte; Jörg H Kleinschmidt
The major outer membrane protein of Fusobacterium nucleatum (FomA) folds and inserts into lipid bilayers via parallel folding pathways.
Journal of molecular biology 2006;355(3):548-61.
2005: Christine Peinelt; Hans-Jürgen Apell
Kinetics of Ca2+ binding to the SR Ca-ATPase in the E1 state.
Biophysical journal 2005;89(4):2427-33.
2005: Robert Stimac; Franz Kerek; Hans-Jürgen Apell
Mechanism of the Na,K-ATPase inhibition by MCS derivatives.
The Journal of membrane biology 2005;205(2):89-101.
2005: Anna Diller; Olga Vagin; George Sachs; Hans-Jürgen Apell
Electrogenic partial reactions of the gastric H,K-ATPase.
Biophysical journal 2005;88(5):3348-59.
2004: Frank Killig; Günther Stark; Hans-Jürgen Apell
Photodynamic inactivation of the Na,K-ATPase occurs via different pathways.
The Journal of membrane biology 2004;200(3):133-44.
2004: Hans-Jürgen Apell
How do P-type ATPases transport ions?
Bioelectrochemistry (Amsterdam, Netherlands) 2004;63(1-2):149-56.
2004: Christine Peinelt; Hans-Jürgen Apell
Time-resolved charge movements in the sarcoplasmatic reticulum Ca-ATPase.
Biophysical journal 2004;86(2):815-24.
2003: Robert Stimac; Franz Kerek; Hans-Jürgen Apell
Macrocyclic carbon suboxide oligomers as potent inhibitors of the Na,K-ATPase.
Annals of the New York Academy of Sciences 2003;986():327-9.
2003: Christine Peinelt; Hans-Jürgen Apell
Time-resolved partial reactions of the SR Ca-ATPase investigated with a fluorescent styryl dye.
Annals of the New York Academy of Sciences 2003;986():325-6.
2003: Artem G Ayuyan; Valerij S Sokolov; Hans-Jürgen Apell
Salt effects on the kinetics of the electrogenic Na+ transport in the Na,K-ATPase.
Annals of the New York Academy of Sciences 2003;986():252-4.
2003: Valerij S Sokolov; A A Lenz; Hans-Jürgen Apell
Negative changes of the membrane capacitance due to electrogenic Na transport by the Na,K-ATPase.
Annals of the New York Academy of Sciences 2003;986():229-31.
2003: Ronald J Clarke; Paul A Humphrey; Christian Lüpfert; Hans-Jürgen Apell; Flemming Cornelius
Kinetic investigations of the mechanism of the rate-determining step of the Na+,K+-ATPase pump cycle.
Annals of the New York Academy of Sciences 2003;986():159-62.
2003: Hans-Jürgen Apell
Toward an understanding of ion transport through the Na,K-ATPase.
Annals of the New York Academy of Sciences 2003;986():133-40.
2003: Hans-Jürgen Apell
Structure-function relationship in P-type ATPases--a biophysical approach.
Reviews of physiology, biochemistry and pharmacology 2003;150():1-35.
2002: Franz Kerek; Robert Stimac; Hans-Jürgen Apell; Frank Freudenmann; Luis Moroder
Characterization of the macrocyclic carbon suboxide factors as potent Na,K-ATPase and SR Ca-ATPase inhibitors.
Biochimica et biophysica acta 2002;1567(1-2):213-20.
2002: Hans-Jürgen Apell; Anna Diller
Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?
FEBS letters 2002;532(1-2):198-202.
2002: Madhan Masilamani; Hans-Jürgen Apell; Harald Illges
Purification and characterization of soluble CD21 from human plasma by affinity chromatography and density gradient centrifugation.
Journal of immunological methods 2002;270(1):11-8.
2002: Paul A Humphrey; Christian Lüpfert; Hans-Jürgen Apell; Flemming Cornelius; Ronald J Clarke
Mechanism of the rate-determining step of the Na(+),K(+)-ATPase pump cycle.
Biochemistry 2002;41(30):9496-507.
2002: M Pedersen; M Roudna; S Beutner; M Birmes; B Reifers; Hans D Martin; Hans-Jürgen Apell
Detection of charge movements in ion pumps by a family of styryl dyes.
The Journal of membrane biology 2002;185(3):221-36.
2002: Christine Peinelt; Hans-Jürgen Apell
Kinetics of the Ca(2+), H(+), and Mg(2+) interaction with the ion-binding sites of the SR Ca-ATPase.
Biophysical journal 2002;82(1 Pt 1):170-81.
2001: Valerij S Sokolov; Artem G Ayuyan; Hans-Jürgen Apell
Assignment of charge movements to electrogenic reaction steps of Na,K-ATPase by analysis of salt effects on the kinetics of charge movements.
European biophysics journal : EBJ 2001;30(7):515-27.
2001: Christian Lüpfert; Ernst Grell; V Pintschovius; Hans-Jürgen Apell; Flemming Cornelius; Ronald J Clarke
Rate limitation of the Na(+),K(+)-ATPase pump cycle.
Biophysical journal 2001;81(4):2069-81.
2001: Hans-Jürgen Apell; Steven J D Karlish
Functional properties of Na,K-ATPase, and their structural implications, as detected with biophysical techniques.
The Journal of membrane biology 2001;180(1):1-9.
2001: A Schneeberger; Hans-Jürgen Apell
Ion selectivity of the cytoplasmic binding sites of the Na,K-ATPase: II. Competition of various cations.
The Journal of membrane biology 2001;179(3):263-73.
2000: Alla Shainskaya; A Schneeberger; Hans-Jürgen Apell; Steven J D Karlish
Entrance port for Na(+) and K(+) ions on Na(+),K(+)-ATPase in the cytoplasmic loop between trans-membrane segments M6 and M7 of the alpha subunit. Proximity Of the cytoplasmic segment of the beta subunit.
The Journal of biological chemistry 2000;275(3):2019-28.
1999: W Domaszewicz; Hans-Jürgen Apell
Binding of the third Na+ ion to the cytoplasmic side of the Na,K-ATPase is electrogenic.
FEBS letters 1999;458(2):241-6.
1999: Olaf S Andersen; Hans-Jürgen Apell; E Bamberg; D D Busath; Roger E Koeppe; F J Sigworth; G Szabo; D W Urry; A Woolley
Gramicidin channel controversy--the structure in a lipid environment.
Nature structural biology 1999;6(7):609; discussion 611-2.
1999: A Linder; Ulrich Weiland; Hans-Jürgen Apell
Novel polymer substrates for SFM investigations of living cells, biological membranes, and proteins.
Journal of structural biology 1999;126(1):16-26.
1999: A Schneeberger; Hans-Jürgen Apell
Ion selectivity of the cytoplasmic binding sites of the Na,K-ATPase: I. Sodium binding is associated with a conformational rearrangement.
The Journal of membrane biology 1999;168(3):221-8.
1999: C Butscher; M Roudna; Hans-Jürgen Apell
Electrogenic partial reactions of the SR-Ca-ATPase investigated by a fluorescence method.
The Journal of membrane biology 1999;168(2):169-81.
1998: Ronald J Clarke; David J Kane; Hans-Jürgen Apell; M Roudna; Ernst Bamberg
Kinetics of Na(+)-dependent conformational changes of rabbit kidney Na+,K(+)-ATPase.
Biophysical journal 1998;75(3):1340-53.
1998: Hans-Jürgen Apell; A Schneeberger; Valerij S Sokolov
Partial reactions of the Na,K-ATPase: kinetic analysis and transport properties.
Acta physiologica Scandinavica. Supplementum 1998;643():235-45.
1998: A P Demchenko; J Gallay; M Vincent; Hans-Jürgen Apell
Fluorescence heterogeneity of tryptophans in Na,K-ATPase: evidences for temperature-dependent energy transfer.
Biophysical chemistry 1998;72(3):265-83.
1998: Valerij S Sokolov; Hans-Jürgen Apell; John E T Corrie; David R Trentham
Fast transient currents in Na,K-ATPase induced by ATP concentration jumps from the P3-[1-(3',5'-dimethoxyphenyl)-2-phenyl-2-oxo]ethyl ester of ATP.
Biophysical journal 1998;74(5):2285-98.
1998: Valerij S Sokolov; SM Stukolov; AS Darmostuk; Hans-Jürgen Apell
Influence of sodium concentration on changes of membrane capacitance associated with the electrogenic ion transport by the Na,K-ATPase.
European biophysics journal : EBJ 1998;27(6):605-17.
1998: Valerij S Sokolov; SM Stukolov; AS Darmostuk; Hans-Jürgen Apell
Study of the non-steady state electrogenic transport of sodium ions by Na+,K(+)-ATPase by the capacitance measurement method.
Membrane & cell biology 1998;11(5):653-78.
1997: W Domaszewicz; A Schneeberger; Hans-Jürgen Apell
Properties of the cytoplasmic ion binding sites.
Annals of the New York Academy of Sciences 1997;834():420-3.
1997: Valerij S Sokolov; SM Stukolov; N M Gevondyan; Hans-Jürgen Apell
Study of electrogenic transport of sodium ions inside the Na,K-ATPase by means of membrane capacitance measurements.
Annals of the New York Academy of Sciences 1997;834():364-6.
1997: Hans-Jürgen Apell
Kinetic and energetic aspects of Na+/K(+)-transport cycle steps.
Annals of the New York Academy of Sciences 1997;834():221-30.
1997: M Mense; Günther Stark; Hans-Jürgen Apell
Effects of free radicals on partial reactions of the Na,K-ATPase.
The Journal of membrane biology 1997;156(1):63-71.
1996: Hans-Jürgen Apell; M Roudna; John E T Corrie; David R Trentham
Kinetics of the phosphorylation of Na,K-ATPase by inorganic phosphate detected by a fluorescence method.
Biochemistry 1996;35(33):10922-30.
1995: N V Visser; Arie van Hoek; Antonie J W G Visser; J Frank; Hans-Jürgen Apell; Ronald J Clarke
Time-resolved fluorescence investigations of the interaction of the voltage-sensitive probe RH421 with lipid membranes and proteins.
Biochemistry 1995;34(37):11777-84.
1995: I Wuddel; Hans-Jürgen Apell
Electrogenicity of the sodium transport pathway in the Na,K-ATPase probed by charge-pulse experiments.
Biophysical journal 1995;69(3):909-21.
1995: R Bühler; Hans-Jürgen Apell
Sequential potassium binding at the extracellular side of the Na,K-pump.
The Journal of membrane biology 1995;145(2):165-73.
1995: S Schulz; Hans-Jürgen Apell
Investigation of ion binding to the cytoplasmic binding sites of the Na,K-pump.
European biophysics journal : EBJ 1995;23(6):413-21.
1994: Hans-Jürgen Apell
Separation and characterization of Na+,K(+)-ATPase containing vesicles.
Biochimica et biophysica acta 1994;1196(1):29-37.
1994: K Hitschke; R Bühler; Hans-Jürgen Apell; Günther Stark
Inactivation of the Na, K-ATPase by radiation-induced free radicals. Evidence for a radical-chain mechanism.
FEBS letters 1994;353(3):297-300.
1994: B Schwappach; W Stürmer; Hans-Jürgen Apell; S J Karlish
Binding of sodium ions and cardiotonic steroids to native and selectively trypsinized Na,K pump, detected by charge movements.
The Journal of biological chemistry 1994;269(34):21620-6.
1994: S Heyse; I Wuddel; Hans-Jürgen Apell; W Stürmer
Partial reactions of the Na,K-ATPase: determination of rate constants.
The Journal of general physiology 1994;104(2):197-240.
1993: A P Demchenko; Hans-Jürgen Apell; W Stürmer; B Feddersen
Fluorescence spectroscopic studies on equilibrium dipole-relaxational dynamics of Na,K-ATPase.
Biophysical chemistry 1993;48(2):135-47.
1993: R Riek; Hans-Jürgen Apell
Investigation of reconstitution of the Na, K-ATPase in lipid vesicles.
Biochimica et biophysica acta 1993;1148(2):321-30.
1992: W Stürmer; Hans-Jürgen Apell
Fluorescence study on cardiac glycoside binding to the Na,K-pump. Ouabain binding is associated with movement of electrical charge.
FEBS letters 1992;300(1):1-4.
1992: J Nieto-Frausto; P Lüger; Hans-Jürgen Apell
Electrostatic coupling of ion pumps.
Biophysical journal 1992;61(1):83-95.
1991: W Stürmer; R Bühler; Hans-Jürgen Apell; P Läuger
Charge translocation by the Na,K-pump: II. Ion binding and release at the extracellular face.
The Journal of membrane biology 1991;121(2):163-76.
1991: R Bühler; W Stürmer; Hans-Jürgen Apell; P Läuger
Charge translocation by the Na,K-pump: I. Kinetics of local field changes studied by time-resolved fluorescence measurements.
The Journal of membrane biology 1991;121(2):141-61.
1990: Hans-Jürgen Apell; Marc Solioz
Electrogenic transport by the Enterococcus hirae ATPase.
Biochimica et biophysica acta 1990;1017(3):221-8.
1990: Hans-Jürgen Apell; V Häring; M Roudna
Na,K-ATPase in artificial lipid vesicles. Comparison of Na,K and Na-only pumping mode.
Biochimica et biophysica acta 1990;1023(1):81-90.
1989: Ronald J Clarke; Hans-Jürgen Apell
A stopped-flow kinetic study of the interaction of potential-sensitive oxonol dyes with lipid vesicles.
Biophysical chemistry 1989;34(3):225-37.
1989: U P Fringeli; Hans-Jürgen Apell; M Fringeli; P Läuger
Polarized infrared absorption of Na+/K+-ATPase studied by attenuated total reflection spectroscopy.
Biochimica et biophysica acta 1989;984(3):301-12.
1989: Hans-Jürgen Apell
Electrogenic properties of the Na,K pump.
The Journal of membrane biology 1989;110(2):103-14.
1989: W Stürmer; Hans-Jürgen Apell; I Wuddel; P Läuger
Conformational transitions and change translocation by the Na,K pump: comparison of optical and electrical transients elicited by ATP-concentration jumps.
The Journal of membrane biology 1989;110(1):67-86.
1989: Ronald J Clarke; Hans-Jürgen Apell; P Läuger
Pump current and Na+/K+ coupling ratio of Na+/K+-ATPase in reconstituted lipid vesicles.
Biochimica et biophysica acta 1989;981(2):326-36.
1988: H Alpes; Hans-Jürgen Apell; G Knoll; Helmut Plattner; R Riek
Reconstitution of Na+/K+-ATPase into phosphatidylcholine vesicles by dialysis of nonionic alkyl maltoside detergents.
Biochimica et biophysica acta 1988;946(2):379-88.
1988: P Läuger; Hans-Jürgen Apell
Voltage dependence of partial reactions of the Na+/K+ pump: predictions from microscopic models.
Biochimica et biophysica acta 1988;945(1):1-10.
1988: P Läuger; Hans-Jürgen Apell
Transient behaviour of the Na+/K+-pump: microscopic analysis of nonstationary ion-translocation.
Biochimica et biophysica acta 1988;944(3):451-64.
1988: R Borlinghaus; Hans-Jürgen Apell
Current transients generated by the Na+/K+-ATPase after an ATP concentration jump: dependence on sodium and ATP concentration.
Biochimica et biophysica acta 1988;939(2):197-206.
1988: R T Borlinghaus; Hans-Jürgen Apell; P Läuger
Fast charge translocations associated with partial reactions of Na,K-ATPase induced by ATP concentration-jump.
Progress in clinical and biological research 1988;268A():477-84.
1988: Hans-Jürgen Apell; B Bersch
Na,K-ATPase in artificial lipid vesicles: potential dependent transport rates investigated by a fluorescence method.
Progress in clinical and biological research 1988;268A():469-76.
1987: Hans-Jürgen Apell; B Bersch
Oxonol VI as an optical indicator for membrane potentials in lipid vesicles.
Biochimica et biophysica acta 1987;903(3):480-94.
1987: Hans-Jürgen Apell; R Borlinghaus; P Läuger
Fast charge translocations associated with partial reactions of the Na,K-pump: II. Microscopic analysis of transient currents.
The Journal of membrane biology 1987;97(3):179-91.
1987: R Borlinghaus; Hans-Jürgen Apell; P Läuger
Fast charge translocations associated with partial reactions of the Na,K-pump: I. Current and voltage transients after photochemical release of ATP.
The Journal of membrane biology 1987;97(3):161-78.
1986: Hans-Jürgen Apell; M M Marcus
(Na+ + K+)-ATPase in artificial lipid vesicles: influence of the concentration of mono- and divalent cations on the pumping rate.
Biochimica et biophysica acta 1986;862(2):254-64.
1986: Hans-Jürgen Apell; M T Nelson; M M Marcus; P Läuger
Effects of the ATP, ADP and inorganic phosphate on the transport rate of the Na+,K+-pump.
Biochimica et biophysica acta 1986;857(1):105-15.
1986: M M Marcus; Hans-Jürgen Apell; M Roudna; Reto Schwendener; H G Weder; P Läuger
(Na+ + K+)-ATPase in artificial lipid vesicles: influence of lipid structure on pumping rate.
Biochimica et biophysica acta 1986;854(2):270-8.
1985: Hans-Jürgen Apell; M M Marcus; B M Anner; H Oetliker; P Läuger
Optical study of active ion transport in lipid vesicles containing reconstituted Na,K-ATPase.
The Journal of membrane biology 1985;85(1):49-63.
1982: P Läuger; Hans-Jürgen Apell
Jumping frequencies in membrane channels. Comparison between stochastic molecular dynamics simulation and rate theory.
Biophysical chemistry 1982;16(3):209-21.