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Lu Gan

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Martina Metzler; Lu Gan; Gelareh Mazarei; Graham Kyrenia Rona; Lili Liu; Nagat Bissada; Ge Lu; Blair R Leavitt; Michael R Hayden
Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.
Martina Metzler; Lu Gan; Tak Pan Wong; Lidong Liu; Jeffrey R Helm; Lili Liu; John Georgiou; Yushan Wang; Nagat Bissada; Kevin Cheng; John C Roder; Yu Tian Wang; Michael R Hayden
NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1.
Anat Yanai; Kun Huang; Rujun Kang; Roshni R Singaraja; Pamela Arstikaitis; Lu Gan; Paul C Orban; Asher Mullard; Catherine M Cowan; Lynn A Raymond; Renaldo C Drisdel; William N Green; Brinda Ravikumar; David C Rubinsztein; Alaa El-Husseini; Michael R Hayden
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.

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All Publications

2010: Martina Metzler; Lu Gan; Gelareh Mazarei; Graham Kyrenia Rona; Lili Liu; Nagat Bissada; Ge Lu; Blair R Leavitt; Michael R Hayden
Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(43):14318-29.
2007: Martina Metzler; Lu Gan; Tak Pan Wong; Lidong Liu; Jeffrey R Helm; Lili Liu; John Georgiou; Yushan Wang; Nagat Bissada; Kevin Cheng; John C Roder; Yu Tian Wang; Michael R Hayden
NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(9):2298-308.
2006: Anat Yanai; Kun Huang; Rujun Kang; Roshni R Singaraja; Pamela Arstikaitis; Lu Gan; Paul C Orban; Asher Mullard; Catherine M Cowan; Lynn A Raymond; Renaldo C Drisdel; William N Green; Brinda Ravikumar; David C Rubinsztein; Alaa El-Husseini; Michael R Hayden
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Nature neuroscience 2006;9(6):824-31.
2005: Simon Warby; Edmond Y W Chan; Martina Metzler; Lu Gan; Roshni R Singaraja; Susan F Crocker; Harold A Robertson; Michael R Hayden
Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.
Human molecular genetics 2005;14(11):1569-77.
2005: Valerie Legendre-Guillemin; Martina Metzler; Jean-Francois Lemaire; Jacynthe Philie; Lu Gan; Michael R Hayden; Peter S McPherson
Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain.
The Journal of biological chemistry 2005;280(7):6101-8.
2003: Martina Metzler; Bo Li; Lu Gan; John Georgiou; Claire-Anne Gutekunst; Yushan Wang; Enrique Torre; Rebecca S Devon; Rosemary Oh; Valerie Legendre-Guillemin; Mark Rich; Christine Alvarez; Marina Gertsenstein; Peter S McPherson; Andras Nagy; Yu Tian Wang; John C Roder; Lynn A Raymond; Michael R Hayden
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.
The EMBO journal 2003;22(13):3254-66.
2002: Roshni R Singaraja; Shinji Hadano; Martina Metzler; Scott Givan; Cheryl L Wellington; Simon Warby; Anat Yanai; Claire-Anne Gutekunst; Blair R Leavitt; Hong Yi; Keith Fichter; Lu Gan; Krista McCutcheon; Vikramjit Chopra; Jennifer Michel; Steven M Hersch; Joh-E Ikeda; Michael R Hayden
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Human molecular genetics 2002;11(23):2815-28.
2002: Valerie Legendre-Guillemin; Martina Metzler; Martine Charbonneau; Lu Gan; Vikramjit Chopra; Jacynthe Philie; Michael R Hayden; Peter S McPherson
HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
The Journal of biological chemistry 2002;277(22):19897-904.
2001: Martina Metzler; Valerie Legendre-Guillemin; Lu Gan; Vikramjit Chopra; Anita Kwok; Peter S McPherson; Michael R Hayden
HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.
The Journal of biological chemistry 2001;276(42):39271-6.
2000: Abigail S Hackam; A S Yassa; Roshni R Singaraja; Martina Metzler; Claire-Anne Gutekunst; Lu Gan; Simon Warby; Cheryl L Wellington; John P Vaillancourt; Nansheng Chen; François G Gervais; L Raymond; Donald W Nicholson; Michael R Hayden
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
The Journal of biological chemistry 2000;275(52):41299-308.
2000: Vikramjit Chopra; Martina Metzler; Dita M Rasper; Asa E Y Engqvist-Goldstein; Roshni R Singaraja; Lu Gan; Keith Fichter; Krista McCutcheon; David G Drubin; Donald W Nicholson; Michael R Hayden
HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(11):1006-15.
2000: Martina Metzler; Cheryl D Helgason; Ioannis Dragatsis; T Zhang; Lu Gan; Nicolas Pineault; Scott Zeitlin; R Keith Humphries; Michael R Hayden
Huntingtin is required for normal hematopoiesis.
Human molecular genetics 2000;9(3):387-94.
1999: Abigail S Hackam; JG Hodgson; Roshni R Singaraja; T Zhang; Lu Gan; Claire-Anne Gutekunst; Steven M Hersch; Michael R Hayden
Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1386):1047-55.
1999: Abigail S Hackam; Roshni R Singaraja; T Zhang; Lu Gan; Michael R Hayden
In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.
Human molecular genetics 1999;8(1):25-33.