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Mahrukh Ganapathi

Research Profile

Anatomy

HL-60 Cells

Chemicals & Drugs

Disorders

Phenomena

Phosphorylation

Physiology

Down-Regulation

Co-author Network

Publications

TOP 3
Jenny J Kim; Brian I Rini; Susan A J Vaziri; Robert Wirka; Robert Dreicer; Paul Elson; Mahrukh K Ganapathi; Jorge A Garcia; Ram Ganapathi
Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib.
Susan A J Vaziri; Laura Wood; Ming Zhou; Hakan Aydin; Ronald M Bukowski; Mahrukh K Ganapathi; Ali-Reza Golshayan; Brian I Rini; Linda Sercia; Emmanuel J Tavares; Ram Ganapathi
Differing von hippel lindau genotype in paired primary and metastatic tumors in patients with clear cell renal cell carcinoma.
Adrian G Grozav; Belinda B Willard; Toshiyuki Kozuki; Kenichi Chikamori; Marius A Micluta; Andrei-Jose Petrescu; Michael Kinter; Ram Ganapathi; Mahrukh K Ganapathi
Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site.

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All Publications

2012: Jenny J Kim; Brian I Rini; Susan A J Vaziri; Robert Wirka; Robert Dreicer; Paul Elson; Mahrukh K Ganapathi; Jorge A Garcia; Ram Ganapathi
Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib.
Cancer 2012;118(7):1946-54.
2012: Susan A J Vaziri; Laura Wood; Ming Zhou; Hakan Aydin; Ronald M Bukowski; Mahrukh K Ganapathi; Ali-Reza Golshayan; Brian I Rini; Linda Sercia; Emmanuel J Tavares; Ram Ganapathi
Differing von hippel lindau genotype in paired primary and metastatic tumors in patients with clear cell renal cell carcinoma.
Frontiers in oncology 2012;2():51.
2011: Adrian G Grozav; Belinda B Willard; Toshiyuki Kozuki; Kenichi Chikamori; Marius A Micluta; Andrei-Jose Petrescu; Michael Kinter; Ram Ganapathi; Mahrukh K Ganapathi
Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site.
Proteomics 2011;11(5):829-42.
2010: Amanda Fader; Nabila Rasool; Susan A J Vaziri; Toshiyuki Kozuki; Pieter W Faber; Paul Elson; Charles V Biscotti; Chad Michener; Peter G Rose; Luis A Rojas-Espaillat; Jerome L Belinson; Mahrukh K Ganapathi; Ram Ganapathi
CCL2 expression in primary ovarian carcinoma is correlated with chemotherapy response and survival outcomes.
Anticancer research 2010;30(12):4791-8.
2010: Susan A J Vaziri; Jenny Kim; Mahrukh K Ganapathi; Ram Ganapathi
Vascular endothelial growth factor polymorphisms: role in response and toxicity of tyrosine kinase inhibitors.
Current oncology reports 2010;12(2):102-8.
2009: Susan A J Vaziri; Dale R Grabowski; Jason Hill; Lisa R Rybicki; Robert Burk; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Inhibition of proteasome activity by bortezomib in renal cancer cells is p53 dependent and VHL independent.
Anticancer research 2009;29(8):2961-9.
2009: Adrian G Grozav; Kenichi Chikamori; Toshiyuki Kozuki; Dale R Grabowski; Ronald M Bukowski; Belinda Willard; Michael Kinter; Anni H Andersen; Ram Ganapathi; Mahrukh K Ganapathi
Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.
Nucleic acids research 2009;37(2):382-92.
2006: Kenichi Chikamori; Jason E Hill; Dale R Grabowski; E Zarkhin; A G Grozav; Susan A J Vaziri; J Wang; Andrei V Gudkov; Lisa R Rybicki; Ronald M Bukowski; A Yen; M Tanimoto; Mahrukh K Ganapathi; Ram Ganapathi
Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.
Leukemia 2006;20(10):1809-18.
2006: Nagio Takigawa; Susan A J Vaziri; Dale R Grabowski; Kenichi Chikamori; Lisa R Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi; Tarek Mekhail
Proteasome inhibition with bortezomib enhances activity of topoisomerase I-targeting drugs by NF-kappaB-independent mechanisms.
Anticancer research 2006;26(3A):1869-76.
2005: Susan A J Vaziri; Jason Hill; Kenichi Chikamori; Dale R Grabowski; Nagio Takigawa; Mamta Chawla-Sarkar; Lisa R Rybicki; Andrei V Gudkov; Tarek Mekhail; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin.
Molecular cancer therapeutics 2005;4(12):1880-90.
2005: Katerina V Gurova; Jason E Hill; Canhui Guo; Anatoly Prokvolit; Lyudmila G Burdelya; Eugenia Samoylova; Anna V Khodyakova; Ram Ganapathi; Mahrukh K Ganapathi; Natalia D Tararova; Dmitry Bosykh; Dmitriy Lvovskiy; Thomas R Webb; George R Stark; Andrei V Gudkov
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17448-53.
2003: Tarek Mekhail; Rika Kawanishi-Tabata; Raymond Tubbs; Andrew C Novick; Paul Elson; Ram Ganapathi; Mahrukh K Ganapathi; Ronald Bukowski
Renal cell carcinoma (RCC) and telomerase activity: relationship to stage.
Urologic oncology 2003;21(6):424-30.
2003: Susan A J Vaziri; Dale R Grabowski; Masahiro Tabata; Katherine A Holmes; Joseph Sterk; Nagio Takigawa; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis.
Anticancer research 2003;23(5A):3657-61.
2003: Kenichi Chikamori; Dale R Grabowski; Michael Kinter; Belinda B Willard; Satya Yadav; Ruedi Aebersold; Ronald M Bukowski; Ian D Hickson; Anni H Andersen; Ram Ganapathi; Mahrukh K Ganapathi
Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
The Journal of biological chemistry 2003;278(15):12696-702.
2002: Rika Kawanishi-Tabata; Francisco Lopez; Sam Fratantonio; Nam Kim; John R Goldblum; Raymond Tubbs; Paul Elson; Ian C Lavery; Ronald M Bukowski; Ram Ganapathi; Mahrukh K Ganapathi
Telomerase activity in stage II colorectal carcinoma.
Cancer 2002;95(9):1834-9.
2002: Ram Ganapathi; Susan A J Vaziri; Masahiro Tabata; Nagio Takigawa; Dale R Grabowski; Ronald M Bukowski; Mahrukh K Ganapathi
Inhibition of NF-kappaB and proteasome activity in tumors: can we improve the therapeutic potential of topoisomerase I and topoisomerase II poisons.
Current pharmaceutical design 2002;8(22):1945-58.
2001: Masahiro Tabata; R Tabata; Dale R Grabowski; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Roles of NF-kappaB and 26 S proteasome in apoptotic cell death induced by topoisomerase I and II poisons in human nonsmall cell lung carcinoma.
The Journal of biological chemistry 2001;276(11):8029-36.
2001: M Aoyama; Dale R Grabowski; Katherine A Holmes; LA Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes.
Biochemical pharmacology 2001;61(1):49-54.
1999: Dale R Grabowski; Katherine A Holmes; M Aoyama; Y Ye; LA Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ian D Hickson; Ram Ganapathi
Altered drug interaction and regulation of topoisomerase IIbeta: potential mechanisms governing sensitivity of HL-60 cells to amsacrine and etoposide.
Molecular pharmacology 1999;56(6):1340-5.
1998: M Aoyama; Dale R Grabowski; G R Dubyak; A I Constantinou; LA Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ian D Hickson; Ram Ganapathi
Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIalpha.
The Biochemical journal 1998;336 ( Pt 3)():727-33.
1998: M Aoyama; Dale R Grabowski; R J Isaacs; KA Krivacic; LA Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ian D Hickson; Ram Ganapathi
Altered expression and activity of topoisomerases during all-trans retinoic acid-induced differentiation of HL-60 cells.
Blood 1998;92(8):2863-70.
1998: M Aoyama; D MacIsaac; Ronald M Bukowski; Mahrukh K Ganapathi
Interleukin 6 differentially potentiates the antitumor effects of taxol and vinblastine in U266 human myeloma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):1039-45.
1996: Mahrukh K Ganapathi; A K Weizer; S Borsellino; Ronald M Bukowski; Ram Ganapathi; T Rice; G Casey; K Kawamura
Resistance to interleukin 6 in human non-small cell lung carcinoma cell lines: role of receptor components.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(7):923-9.