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Don Ganem

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Henry H Chang; Don Ganem
A Unique Herpesviral Transcriptional Program in KSHV-Infected Lymphatic Endothelial Cells Leads to mTORC1 Activation and Rapamycin Sensitivity.
Kevin F Brulois; Heesoon Chang; Armin Ensser; Don Ganem; Shou-Jiang Gao; Jihyun F Kim; Amy Si-Ying Lee; Hye-Ra Lee; Sun Hwa Lee; Jinjong Myoung; Tae-Kwang Oh; Zsolt Toth; Lai-Yee Wong; Jae U. Jung
Construction and manipulation of a new Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome clone.
Alexis Spain Madrid; Don Ganem
Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44.

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All Publications

2013: Henry H Chang; Don Ganem
A Unique Herpesviral Transcriptional Program in KSHV-Infected Lymphatic Endothelial Cells Leads to mTORC1 Activation and Rapamycin Sensitivity.
Cell host & microbe 2013;13(4):429-40.
2012: Kevin F Brulois; Heesoon Chang; Armin Ensser; Don Ganem; Shou-Jiang Gao; Jihyun F Kim; Amy Si-Ying Lee; Hye-Ra Lee; Sun Hwa Lee; Jinjong Myoung; Tae-Kwang Oh; Zsolt Toth; Lai-Yee Wong; Jae U. Jung
Construction and manipulation of a new Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome clone.
Journal of virology 2012;86(18):9708-20.
2012: Alexis Spain Madrid; Don Ganem
Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44.
Journal of virology 2012;86(16):8693-704.
2012: Deanna Lee; Ka-Cheung Luk; Ross Molinaro; Xiaoxing Qiu; Gerald Schochetman; Robert H Silverman; Graham Simmons; Imke Steffen; Ning Tang; Anatoly Urisman; Jaydip Das Gupta; Joe L DeRisi; Nicole Fischer; Don Ganem; Christina Gaughan; John Hackett; Eric A Klein; Miranda Broz; Charles Y Chiu
In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.
PloS one 2012;7(9):e44954.
2011: Jinjong Myoung; Don Ganem
Infection of lymphoblastoid cell lines by Kaposi's sarcoma-associated herpesvirus: critical role of cell-associated virus.
Journal of virology 2011;85(19):9767-77.
2011: Jinjong Myoung; Don Ganem
Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: maintenance of tight latency with efficient reactivation upon induction.
Journal of virological methods 2011;174(1-2):12-21.
2011: Horng-Ru Lin; Don Ganem
Viral microRNA target allows insight into the role of translation in governing microRNA target accessibility.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(13):5148-53.
2010: Sanjay Chandriani; Yiyang Xu; Don Ganem
The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes.
Journal of virology 2010;84(16):7934-42.
2010: Yiyang Xu; Don Ganem
Making sense of antisense: seemingly noncoding RNAs antisense to the master regulator of Kaposi's sarcoma-associated herpesvirus lytic replication do not regulate that transcript but serve as mRNAs encoding small peptides.
Journal of virology 2010;84(11):5465-75.
2010: Sanjay Chandriani; Don Ganem
Array-based transcript profiling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2010;84(11):5565-73.
2010: Don Ganem; Amy L Kistler; Joe L DeRisi
Achalasia and viral infection: new insights from veterinary medicine.
Science translational medicine 2010;2(33):33ps24.
2010: C Y Chiu; A L Greninger; E C Chen; T D Haggerty; J Parsonnet; Eric L Delwart; Joe L DeRisi; Don Ganem
Cultivation and serological characterization of a human Theiler's-like cardiovirus associated with diarrheal disease.
Journal of virology 2010;84(9):4407-14.
2010: Don Ganem
KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine.
The Journal of clinical investigation 2010;120(4):939-49.
2009: Priya Bellare; Don Ganem
Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivation.
Cell host & microbe 2009;6(6):570-5.
2009: Sabine A Bisson; Anne-Laure Page; Don Ganem
A Kaposi's sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins, and blocks interferon-mediated signal transduction.
Journal of virology 2009;83(10):5056-66.
2009: Christopher S Sullivan; Chang K Sung; Christopher D Pack; Adam Grundhoff; Aron E Lukacher; Thomas L Benjamin; Don Ganem
Murine Polyomavirus encodes a microRNA that cleaves early RNA transcripts but is not essential for experimental infection.
Virology 2009;387(1):157-67.
2009: Joseph M Ziegelbauer; Christopher S Sullivan; Don Ganem
Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs.
Nature genetics 2009;41(1):130-4.
2008: Charles Y Chiu; Alexander L Greninger; Kimberly Kanada; Thomas Kwok; Kael F Fischer; Charles Runckel; Janice K Louie; Carol A Glaser; Shigeo Yagi; David P Schnurr; Tom D Haggerty; Julie Parsonnet; Don Ganem; Joe L DeRisi
Identification of cardioviruses related to Theiler's murine encephalomyelitis virus in human infections.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):14124-9.
2008: Charles Y Chiu; Anatoly Urisman; Tara L Greenhow; Silvi Rouskin; Shigeo Yagi; David P Schnurr; Carolyn Wright; W Lawrence Drew; David Wang; Peggy S Weintrub; Joe L DeRisi; Don Ganem
Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children.
The Journal of pediatrics 2008;153(1):76-83.
2008: Claudia Grossmann; Don Ganem
Effects of NFkappaB activation on KSHV latency and lytic reactivation are complex and context-dependent.
Virology 2008;375(1):94-102.
2008: Amy L Kistler; Ady Gancz; Susan Clubb; Peter Skewes-Cox; Kael Fischer; Katherine Sorber; Charles Y Chiu; Avishai Lublin; Sara Mechani; Yigal Farnoushi; Alexander Greninger; Christopher C Wen; Scott B Karlene; Don Ganem; Joe L DeRisi
Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent.
Virology journal 2008;5():88.
2007: Amy L Kistler; Pedro C Avila; Silvi Rouskin; David Wang; Theresa Ward; Shigeo Yagi; David P Schnurr; Don Ganem; Joe L DeRisi; Homer A Boushey
Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity.
The Journal of infectious diseases 2007;196(6):817-25.
2007: Charles Y Chiu; Ash A Alizadeh; Silvi Rouskin; Jason D Merker; Elaine Yeh; Shigeo Yagi; David P Schnurr; Bruce K Patterson; Don Ganem; Joe L DeRisi
Diagnosis of a critical respiratory illness caused by human metapneumovirus by use of a pan-virus microarray.
Journal of clinical microbiology 2007;45(7):2340-3.
2007: Martin Rowe; Britt Glaunsinger; Daphne van Leeuwen; Jianmin Zuo; David Sweetman; Don Ganem; Jaap Middeldorp; Emmanuel J H J Wiertz; Maaike E Ressing
Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3366-71.
2007: Beihua Dong; Sanggu Kim; Seunghee Hong; Jaydip Das Gupta; Krishnamurthy Malathi; Eric A Klein; Don Ganem; Joe L DeRisi; Samson A Chow; Robert H Silverman
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1655-60.
2007: Yiyiang Xu; Don Ganem
Induction of chemokine production by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.
The Journal of general virology 2007;88(Pt 1):46-50.
2006: Charles Y Chiu; Silvi Rouskin; Anita Koshy; Anatoly Urisman; Kael Fischer; Shigeo Yagi; David P Schnurr; Paul B Eckburg; Lucy S Tompkins; Brian G Blackburn; Jason D Merker; Bruce K Patterson; Don Ganem; Joe L DeRisi
Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;43(8):e71-6.
2006: Claudia Grossmann; Simona Podgrabinska; Mihaela Skobe; Don Ganem
Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype.
Journal of virology 2006;80(14):7179-85.
2006: Craig McCormick; Don Ganem
Phosphorylation and function of the kaposin B direct repeats of Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2006;80(12):6165-70.
2006: Adam Grundhoff; Christopher S Sullivan; Don Ganem
A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses.
RNA (New York, N.Y.) 2006;12(5):733-50.
2006: Anatoly Urisman; Ross J Molinaro; Nicole Fischer; Sarah J Plummer; Graham Casey; Eric A Klein; Krishnamurthy Malathi; Cristina Magi-Galluzzi; Raymond R Tubbs; Don Ganem; Robert H Silverman; Joe L DeRisi
Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
PLoS pathogens 2006;2(3):e25.
2006: Joseph Ziegelbauer; Adam Grundhoff; Don Ganem
Exploring the DNA binding interactions of the Kaposi's sarcoma-associated herpesvirus lytic switch protein by selective amplification of bound sequences in vitro.
Journal of virology 2006;80(6):2958-67.
2006: Don Ganem
KSHV infection and the pathogenesis of Kaposi's sarcoma.
Annual review of pathology 2006;1():273-96.
2006: Christopher S Sullivan; Adam Grundhoff; S Tevethia; R Treisman; James M Pipas; Don Ganem
Expression and function of microRNAs in viruses great and small.
Cold Spring Harbor symposia on quantitative biology 2006;71():351-6.
2006: Britt Glaunsinger; Don Ganem
Messenger RNA turnover and its regulation in herpesviral infection.
Advances in virus research 2006;66():337-94.
2005: Christopher S Sullivan; Don Ganem
MicroRNAs and viral infection.
Molecular cell 2005;20(1):3-7.
2005: Jill Bechtel; Adam Grundhoff; Don Ganem
RNAs in the virion of Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2005;79(16):10138-46.
2005: Christopher S Sullivan; Adam Grundhoff; Satvir Tevethia; James M Pipas; Don Ganem
SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells.
Nature 2005;435(7042):682-6.
2005: Britt Glaunsinger; Leonard Chavez; Don Ganem
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
Journal of virology 2005;79(12):7396-401.
2005: Christopher S Sullivan; Don Ganem
A virus-encoded inhibitor that blocks RNA interference in mammalian cells.
Journal of virology 2005;79(12):7371-9.
2005: David Jesse Sanchez; Jenny E Gumperz; Don Ganem
Regulation of CD1d expression and function by a herpesvirus infection.
The Journal of clinical investigation 2005;115(5):1369-78.
2005: Jill T Bechtel; Richard C Winant; Don Ganem
Host and viral proteins in the virion of Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2005;79(8):4952-64.
2005: Craig McCormick; Don Ganem
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
Science (New York, N.Y.) 2005;307(5710):739-41.
2004: Britt Glaunsinger; Don Ganem
Highly selective escape from KSHV-mediated host mRNA shutoff and its implications for viral pathogenesis.
The Journal of experimental medicine 2004;200(3):391-8.
2004: Yuying Liang; Don Ganem
RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA.
Journal of virology 2004;78(13):6818-26.
2004: Britt Glaunsinger; Don Ganem
Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover.
Molecular cell 2004;13(5):713-23.
2004: Don Ganem; Alfred M Prince
Hepatitis B virus infection--natural history and clinical consequences.
The New England journal of medicine 2004;350(11):1118-29.
2004: Rolf Renne; Dirk P Dittmer; Dean H Kedes; K Schmidt; R C Desrosiers; Paul A Luciw; Don Ganem
Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SIV-positive and SIV-negative rhesus macaques.
Journal of medical primatology 2004;33(1):1-9.
2004: Adam Grundhoff; Don Ganem
Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.
The Journal of clinical investigation 2004;113(1):124-36.
2003: David Wang; Anatoly Urisman; Yu-Tsueng Liu; Michael Springer; Thomas G Ksiazek; Dean D Erdman; Elaine R Mardis; Matthew Hickenbotham; vincent magrini; James Eldred; J Phillipe Latreille; Richard K Wilson; Don Ganem; Joe L DeRisi
Viral discovery and sequence recovery using DNA microarrays.
PLoS biology 2003;1(2):E2.
2003: Yuying Liang; Don Ganem
Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8490-5.
2003: Jill T Bechtel; Yuying Liang; Joshua Hvidding; Don Ganem
Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells.
Journal of virology 2003;77(11):6474-81.
2003: Adam Grundhoff; Don Ganem
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids.
Journal of virology 2003;77(4):2779-83.
2003: Laurent Coscoy; Don Ganem
PHD domains and E3 ubiquitin ligases: viruses make the connection.
Trends in cell biology 2003;13(1):7-12.
2002: David Wang; Laurent Coscoy; Maxine Zylberberg; Pedro C Avila; Homer A Boushey; Don Ganem; Joe L DeRisi
Microarray-based detection and genotyping of viral pathogens.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15687-92.
2002: Yuying Liang; Jean Chang; Stephen J Lynch; David M Lukac; Don Ganem
The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.
Genes & development 2002;16(15):1977-89.
2002: Andrew G Polson; David Wang; Joe L DeRisi; Don Ganem
Modulation of host gene expression by the constitutively active G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus.
Cancer research 2002;62(15):4525-30.
2002: Michael Lagunoff; Jill Bechtel; Eleni Venetsanakos; Anne-Marie Roy; Nancy W Abbey; Brian G Herndier; Martin McMahon; Don Ganem
De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells.
Journal of virology 2002;76(5):2440-8.
2002: David Jesse Sanchez; Laurent Coscoy; Don Ganem
Functional organization of MIR2, a novel viral regulator of selective endocytosis.
The Journal of biological chemistry 2002;277(8):6124-30.
2001: Laurent Coscoy; D J Sanchez; Don Ganem
A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition.
The Journal of cell biology 2001;155(7):1265-73.
2001: Don Ganem
Virology. The X files--one step closer to closure.
Science (New York, N.Y.) 2001;294(5550):2299-300.
2001: Y T Liu; Robert Brazas; Don Ganem
Efficient hepatitis delta virus RNA replication in avian cells requires a permissive factor(s) from mammalian cells.
Journal of virology 2001;75(16):7489-93.
2001: David M Lukac; L Garibyan; JR Kirshner; Diana Palmeri; Don Ganem
DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters.
Journal of virology 2001;75(15):6786-99.
2001: Christian Brander; P O'Connor; Todd J Suscovich; Norman Jones; Y Lee; Dean H Kedes; Don Ganem; J Martin; Dennis H Osmond; S Southwood; Alessandro Sette; Bruce D Walker; David T Scadden
Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.
The Journal of infectious diseases 2001;184(2):119-26.
2001: Michael Lagunoff; David M Lukac; Don Ganem
Immunoreceptor tyrosine-based activation motif-dependent signaling by Kaposi's sarcoma-associated herpesvirus K1 protein: effects on lytic viral replication.
Journal of virology 2001;75(13):5891-8.
2001: Laurent Coscoy; Don Ganem
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
The Journal of clinical investigation 2001;107(12):1599-606.
2001: A G Polson; L Huang; David M Lukac; Justin D Blethrow; David O Morgan; Al L Burlingame; Don Ganem
Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases.
Journal of virology 2001;75(7):3175-84.
2001: Adam Grundhoff; Don Ganem
Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2001;75(4):1857-63.
2001: Rolf Renne; C Barry; Dirk P Dittmer; Nicole Compitello; P O Brown; Don Ganem
Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2001;75(1):458-68.
2000: L Wu; Rolf Renne; Don Ganem; Bagher Forghani
Human herpesvirus 8 glycoprotein K8.1: expression, post-translational modification and localization analyzed by monoclonal antibody.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2000;17(2):127-36.
2000: Jean Chang; Don Ganem
On the control of late gene expression in Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8).
The Journal of general virology 2000;81(Pt 8):2039-47.
2000: Laurent Coscoy; Don Ganem
Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):8051-6.
2000: JR Kirshner; David M Lukac; Jean Chang; Don Ganem
Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activities.
Journal of virology 2000;74(8):3586-97.
2000: Jean Chang; Rolf Renne; Dirk P Dittmer; Don Ganem
Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication.
Virology 2000;266(1):17-25.
1999: Dirk P Dittmer; Cheryl A Stoddart; Rolf Renne; Valerie Linquist-Stepps; Mary E Moreno; Christopher Bare; Joseph M McCune; Don Ganem
Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice.
The Journal of experimental medicine 1999;190(12):1857-68.
1999: David M Lukac; JR Kirshner; Don Ganem
Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells.
Journal of virology 1999;73(11):9348-61.
1999: Don Ganem
An advance in liver-specific gene delivery.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11696-7.
1999: Thomas R O'Brien; Dean H Kedes; Don Ganem; D R Macrae; Philip S Rosenberg; J Molden; James J Goedert
Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma.
The Journal of infectious diseases 1999;180(4):1010-7.
1999: JR Kirshner; KA Staskus; A Haase; Michael Lagunoff; Don Ganem
Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi's sarcoma (KS)-associated herpesvirus: implications for KS pathogenesis.
Journal of virology 1999;73(7):6006-14.
1999: R Sadler; L Wu; Bagher Forghani; Rolf Renne; W Zhong; Brian G Herndier; Don Ganem
A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus.
Journal of virology 1999;73(7):5722-30.
1999: Michael Lagunoff; Ravindra Majeti; Arthur Weiss; Don Ganem
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5704-9.
1998: David M Lukac; Rolf Renne; JR Kirshner; Don Ganem
Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein.
Virology 1998;252(2):304-12.
1998: Dirk P Dittmer; Michael Lagunoff; Rolf Renne; KA Staskus; A Haase; Don Ganem
A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus.
Journal of virology 1998;72(10):8309-15.
1998: Y Wei; B Tennant; Don Ganem
In vivo effects of mutations in woodchuck hepatitis virus enhancer II.
Journal of virology 1998;72(8):6608-13.
1998: Rolf Renne; DJ Blackbourn; Denise Whitby; J Levy; Don Ganem
Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells.
Journal of virology 1998;72(6):5182-8.
1998: Jeffrey N Martin; Don Ganem; Dennis H Osmond; Kimberly Page-Shafer; D Macrae; Dean H Kedes
Sexual transmission and the natural history of human herpesvirus 8 infection.
The New England journal of medicine 1998;338(14):948-54.
1998: Y Wei; Don Ganem
Activation of heterologous gene expression by the large isoform of hepatitis delta antigen.
Journal of virology 1998;72(3):2089-96.
1998: Don Ganem
Human herpesvirus 8 and its role in the genesis of Kaposi's sarcoma.
Current clinical topics in infectious diseases 1998;18():237-51.
1997: Dean H Kedes; Michael Lagunoff; Rolf Renne; Don Ganem
Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus.
The Journal of clinical investigation 1997;100(10):2606-10.
1997: S Perri; Don Ganem
Effects of mutations within and adjacent to the terminal repeats of hepatitis B virus pregenomic RNA on viral DNA synthesis.
Journal of virology 1997;71(11):8448-55.
1997: Don Ganem
KSHV and Kaposi's sarcoma: the end of the beginning?
Cell 1997;91(2):157-60.
1997: Michael Lagunoff; Don Ganem
The structure and coding organization of the genomic termini of Kaposi's sarcoma-associated herpesvirus.
Virology 1997;236(1):147-54.
1997: C Diamond; Meei-Li Huang; Dean H Kedes; CE Speck; GW Rankin; Don Ganem; Robert W Coombs; Timothy M Rose; John N Krieger; Lawrence Corey
Absence of detectable human herpesvirus 8 in the semen of human immunodeficiency virus-infected men without Kaposi's sarcoma.
The Journal of infectious diseases 1997;176(3):775-7.
1997: A Unal; Todd R Pray; Michael Lagunoff; Michael Pennington; Don Ganem; Charles S Craik
The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).
Journal of virology 1997;71(9):7030-8.
1997: James J Goedert; Dean H Kedes; Don Ganem
Antibodies to human herpesvirus 8 in women and infants born in Haiti and the USA.
Lancet 1997;349(9062):1368.
1997: Dean H Kedes; Don Ganem
Sensitivity of Kaposi's sarcoma-associated herpesvirus replication to antiviral drugs. Implications for potential therapy.
The Journal of clinical investigation 1997;99(9):2082-6.
1997: Dean H Kedes; Don Ganem; Niloufar Ameli; Peter Bacchetti; Ruth M Greenblatt
The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women.
JAMA : the journal of the American Medical Association 1997;277(6):478-81.
1997: W Zhong; Don Ganem
Characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear RNA encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).
Journal of virology 1997;71(2):1207-12.
1997: KA Staskus; W Zhong; K Gebhard; Brian G Herndier; H Wang; Rolf Renne; J Beneke; J Pudney; D J Anderson; Don Ganem; Ashley T Haase
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells.
Journal of virology 1997;71(1):715-9.
1996: Rolf Renne; Michael Lagunoff; W Zhong; Don Ganem
The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions.
Journal of virology 1996;70(11):8151-4.
1996: Robert Brazas; Don Ganem
A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution.
Science (New York, N.Y.) 1996;274(5284):90-4.
1996: S Perri; Don Ganem
A host factor that binds near the termini of hepatitis B virus pregenomic RNA.
Journal of virology 1996;70(10):6803-9.
1996: Y Wei; J E Tavis; Don Ganem
Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses.
Journal of virology 1996;70(9):6455-8.
1996: Dean H Kedes; Eva A Operskalski; M Busch; R Kohn; J Flood; Don Ganem
The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission.
Nature medicine 1996;2(8):918-24.
1996: W Zhong; H Wang; Brian G Herndier; Don Ganem
Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6641-6.
1996: R Ziermann; Don Ganem
Homologous and heterologous complementation of HBV and WHV capsid and polymerase functions in RNA encapsidation.
Virology 1996;219(2):350-6.
1996: K Ueda; Don Ganem
Apoptosis is induced by N-myc expression in hepatocytes, a frequent event in hepadnavirus oncogenesis, and is blocked by insulin-like growth factor II.
Journal of virology 1996;70(3):1375-83.
1996: Rolf Renne; W Zhong; Brian G Herndier; M McGrath; N Abbey; Dean H Kedes; Don Ganem
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture.
Nature medicine 1996;2(3):342-6.
1996: K Ueda; Y Wei; Don Ganem
Activation of N-myc2 gene expression by cis-acting elements of oncogenic hepadnaviral genomes: key role of enhancer II.
Virology 1996;217(1):413-7.
1996: S Chuck; Robert M Grant; E Katongole-Mbidde; M Conant; Don Ganem
Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi's sarcoma.
The Journal of infectious diseases 1996;173(1):248-51.
1995: T Ishikawa; Don Ganem
The pre-S domain of the large viral envelope protein determines host range in avian hepatitis B viruses.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6259-63.
1995: C Chang; R C Hirsch; Don Ganem
Sequences in the preC region of duck hepatitis B virus affect pregenomic RNA accumulation.
Virology 1995;207(2):549-54.
1994: T Ishikawa; K Kuroki; R Lenhoff; J Summers; Don Ganem
Analysis of the binding of a host cell surface glycoprotein to the preS protein of duck hepatitis B virus.
Virology 1994;202(2):1061-4.
1994: J E Tavis; S Perri; Don Ganem
Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer.
Journal of virology 1994;68(6):3536-43.
1994: K Kuroki; R Cheung; P L Marion; Don Ganem
A cell surface protein that binds avian hepatitis B virus particles.
Journal of virology 1994;68(4):2091-6.
1994: Don Ganem; J R Pollack; J Tavis
Hepatitis B virus reverse transcriptase and its many roles in hepadnaviral genomic replication.
Infectious agents and disease 1994;3(2-3):85-93.
1993: M Tan; R Klein; R Grant; Don Ganem; J Engel
Cloning and characterization of the RNA polymerase alpha-subunit operon of Chlamydia trachomatis.
Journal of bacteriology 1993;175(22):7150-9.
1993: Joel Edward Lavine; Don Ganem
Inhibition of duck hepatitis B virus replication by interferon-gamma.
Journal of medical virology 1993;40(1):59-64.
1993: J E Tavis; Don Ganem
Expression of functional hepatitis B virus polymerase in yeast reveals it to be the sole viral protein required for correct initiation of reverse transcription.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4107-11.
1993: L J Hansen; B C Tennant; C Seeger; Don Ganem
Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses.
Molecular and cellular biology 1993;13(1):659-67.
1992: J Cherrington; R Russnak; Don Ganem
Upstream sequences and cap proximity in the regulation of polyadenylation in ground squirrel hepatitis virus.
Journal of virology 1992;66(12):7589-96.
1992: J Cherrington; Don Ganem
Regulation of polyadenylation in human immunodeficiency virus (HIV): contributions of promoter proximity and upstream sequences.
The EMBO journal 1992;11(4):1513-24.
1992: E Perara; Don Ganem; Joanne N Engel
A developmentally regulated chlamydial gene with apparent homology to eukaryotic histone H1.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2125-9.
1991: D D Loeb; R C Hirsch; Don Ganem
Sequence-independent RNA cleavages generate the primers for plus strand DNA synthesis in hepatitis B viruses: implications for other reverse transcribing elements.
The EMBO journal 1991;10(11):3533-40.
1991: V Bruss; Don Ganem
Mutational analysis of hepatitis B surface antigen particle assembly and secretion.
Journal of virology 1991;65(7):3813-20.
1991: R C Hirsch; D D Loeb; J R Pollack; Don Ganem
cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA.
Journal of virology 1991;65(6):3309-16.
1991: D R Macrae; V Bruss; Don Ganem
Myristylation of a duck hepatitis B virus envelope protein is essential for infectivity but not for virus assembly.
Virology 1991;181(1):359-63.
1991: S Staprans; D D Loeb; Don Ganem
Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA.
Journal of virology 1991;65(3):1255-62.
1991: V Bruss; Don Ganem
The role of envelope proteins in hepatitis B virus assembly.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):1059-63.
1991: Joel Edward Lavine; John R Lake; Nancy L Ascher; L D Ferrell; Don Ganem; Teresa L Wright
Persistent hepatitis B virus following interferon alfa therapy and liver transplantation.
Gastroenterology 1991;100(1):263-7.
1990: Joanne N Engel; J Pollack; E Perara; Don Ganem
Heat shock response of murine Chlamydia trachomatis.
Journal of bacteriology 1990;172(12):6959-72.
1990: Lung-Ji Chang; R C Hirsch; Don Ganem; Harold Varmus
Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase.
Journal of virology 1990;64(11):5553-8.
1990: Joanne N Engel; J Pollack; F Malik; Don Ganem
Cloning and characterization of RNA polymerase core subunits of Chlamydia trachomatis by using the polymerase chain reaction.
Journal of bacteriology 1990;172(10):5732-41.
1990: Lung-Ji Chang; Don Ganem; Harold Varmus
Mechanism of translation of the hepadnaviral polymerase (P) gene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5158-62.
1990: K Kuroki; M Floreani; L T Mimms; Don Ganem
Epitope mapping of the PreS1 domain of the hepatitis B virus large surface protein.
Virology 1990;176(2):620-4.
1990: R Russnak; Don Ganem
Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses.
Genes & development 1990;4(5):764-76.
1990: Joanne N Engel; Don Ganem
A polymerase chain reaction-based approach to cloning sigma factors from eubacteria and its application to the isolation of a sigma-70 homolog from Chlamydia trachomatis.
Journal of bacteriology 1990;172(5):2447-55.
1990: R C Hirsch; Joel Edward Lavine; Lung-Ji Chang; Harold Varmus; Don Ganem
Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription.
Nature 1990;344(6266):552-5.
1990: B E Eble; V R Lingappa; Don Ganem
The N-terminal (pre-S2) domain of a hepatitis B virus surface glycoprotein is translocated across membranes by downstream signal sequences.
Journal of virology 1990;64(3):1414-9.
1989: Joel Edward Lavine; R Hirsch; Don Ganem
A system for studying the selective encapsidation of hepadnavirus RNA.
Journal of virology 1989;63(10):4257-63.
1989: K Kuroki; R Russnak; Don Ganem
Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum.
Molecular and cellular biology 1989;9(10):4459-66.
1989: Lung-Ji Chang; P Pryciak; Don Ganem; Harold Varmus
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting.
Nature 1989;337(6205):364-8.
1989: L M Sardinia; Joanne N Engel; Don Ganem
Chlamydial gene encoding a 70-kilodalton antigen in Escherichia coli: analysis of expression signals and identification of the gene product.
Journal of bacteriology 1989;171(1):335-41.
1988: K Simon; V R Lingappa; Don Ganem
A block to the intracellular transport and assembly of hepatitis B surface antigen polypeptides in Xenopus oocytes.
Virology 1988;166(1):76-81.
1987: Joanne N Engel; Don Ganem
Chlamydial rRNA operons: gene organization and identification of putative tandem promoters.
Journal of bacteriology 1987;169(12):5678-85.
1987: B E Eble; D R MacRae; Vishwanath R Lingappa; Don Ganem
Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen.
Molecular and cellular biology 1987;7(10):3591-601.
1986: B E Eble; Vishwanath R Lingappa; Don Ganem
Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide.
Molecular and cellular biology 1986;6(5):1454-63.