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Detlev Ganten

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Randolph M Nesse; Detlev Ganten; T Ryan Gregory; Gilbert S Omenn
Evolutionary molecular medicine.
Detlev Ganten; Randolph Nesse
The evolution of evolutionary molecular medicine: genomics are transforming evolutionary biology into a science with new importance for modern medicine.
David Fournier; Detlev Ganten; Friedrich C Luft; Michael Bader; Miguel A Andrade-Navarro
Emergence and evolution of the renin-angiotensin-aldosterone system.

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2012: Randolph M Nesse; Detlev Ganten; T Ryan Gregory; Gilbert S Omenn
Evolutionary molecular medicine.
Journal of molecular medicine (Berlin, Germany) 2012;90(5):509-22.
2012: Detlev Ganten; Randolph Nesse
The evolution of evolutionary molecular medicine: genomics are transforming evolutionary biology into a science with new importance for modern medicine.
Journal of molecular medicine (Berlin, Germany) 2012;90(5):467-70.
2012: David Fournier; Detlev Ganten; Friedrich C Luft; Michael Bader; Miguel A Andrade-Navarro
Emergence and evolution of the renin-angiotensin-aldosterone system.
Journal of molecular medicine (Berlin, Germany) 2012;90(5):495-508.
2011: Mazda Adli; Mathias Bonk; Sabine Kleinert; Steve Wesselingh; Detlev Ganten
Science to policy: M8 Alliance invites policy makers to step in.
Lancet 2011;378(9801):1447-9.
2010: Detlev Ganten; Andy Haines; Robert Souhami
Health co-benefits of policies to tackle climate change.
Lancet 2010;376(9755):1802-4.
2010: Mazda Adli; Sabine Kleinert; Stephen K Smith; Detlev Ganten
Academic medicine must take its global role: the M8 Alliance of Academic Health Centers and Medical Universities.
Lancet 2010;376(9748):1197-8.
2010: Aaron J Trask; Leanne Groban; Brian Westwood; Jasmina Varagic; Detlev Ganten; Patricia E Gallagher; Mark C Chappell; Carlos M Ferrario
Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats.
American journal of hypertension 2010;23(6):687-93.
2009: Katsunori Isa; Maria Antonia García-Espinosa; Amy C Arnold; Nancy T Pirro; Ellen N Tommasi; Detlev Ganten; Mark C Chappell; Carlos M Ferrario; Debra I Diz
Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;297(1):R111-5.
2009: Mazda Adli; Sabine Kleinert; antoine lafont; Axel Kahn; Detlev Ganten
Shaping future health: Berlin Evolution of Medicine Summit.
Lancet 2009;373(9663):519-20.
2008: Debra I Diz; Maria Antonia Garcia-Espinosa; Patricia E Gallagher; Detlev Ganten; Carlos M Ferrario; David B Averill
Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats.
Journal of cardiovascular pharmacology 2008;51(6):542-8.
2008: Detlev Ganten; Michael Bader; Jan Steffen Jürgensen
An old couple: the renin-angiotensin system (RAS) and the Journal of Molecular Medicine (JMolMed).
Journal of molecular medicine (Berlin, Germany) 2008;86(6):609-10.
2008: Michael Bader; Detlev Ganten
Update on tissue renin-angiotensin systems.
Journal of molecular medicine (Berlin, Germany) 2008;86(6):615-21.
2008: Amy C Arnold; Atsushi Sakima; Detlev Ganten; Carlos M Ferrario; Debra I Diz
Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen.
Hypertension 2008;51(5):1326-31.
2008: K Bridget Brosnihan; Ping Li; Jorge P Figueroa; Detlev Ganten; Carlos M Ferrario
Estrogen, nitric oxide, and hypertension differentially modulate agonist-induced contractile responses in female transgenic (mRen2)27 hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2008;294(5):H1995-2001.
2007: Detlev Ganten
What is life? On Erwin Schrödinger, his cat, and the Journal of Molecular Medicine.
Journal of molecular medicine (Berlin, Germany) 2007;85(12):1291-2.
2007: Ronnie Folkesson; Katarzyna Malkiewicz; Ewa Kloskowska; Tatjana Nilsson; Elena Popova; Nenad Bogdanovic; Ursula Ganten; Detlev Ganten; Michael Bader; Bengt Winblad; Eirikur Benedikz
A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation.
Biochemical and biophysical research communications 2007;358(3):777-82.
2007: Aaron J Trask; David B Averill; Detlev Ganten; Mark C Chappell; Carlos M Ferrario
Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2007;292(6):H3019-24.
2007: Atsushi Sakima; David B Averill; Sherry O Kasper; Larhonda Jackson; Detlev Ganten; Carlos M Ferrario; Patricia E Gallagher; Debra I Diz
Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen.
American journal of physiology. Heart and circulatory physiology 2007;292(3):H1412-9.
2006: Liomar Neves; Mark C Chappell; Carlos M Ferrario; Patricia E Gallagher; Detlev Ganten; K Bridget Brosnihan
Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats.
Peptides 2006;27(11):2912-8.
2006: Sherry O Kasper; Carlos M Ferrario; Detlev Ganten; Debra I Diz
Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging.
Endocrine 2006;30(2):167-74.
2005: Sherry O Kasper; Christy S Carter; Carlos M Ferrario; Detlev Ganten; León Ferder; William E Sonntag; Patricia E Gallagher; Debra I Diz
Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems.
Physiological genomics 2005;23(3):311-7.
2005: Avtar Lal; John P Veinot; Detlev Ganten; Frans Leenen
Prevention of cardiac remodeling after myocardial infarction in transgenic rats deficient in brain angiotensinogen.
Journal of molecular and cellular cardiology 2005;39(3):521-9.
2005: Chana Yagil; Norbert Hubner; Jan Monti; Herbert Schulz; Marina Sapojnikov; Friedrich C Luft; Detlev Ganten; Yoram Yagil
Identification of hypertension-related genes through an integrated genomic-transcriptomic approach.
Circulation research 2005;96(6):617-25.
2005: Ivana Vanecková; Herbert kramer; Jana Novotná; Ludmila Kazdová; Martin Opocenský; Michael Bader; Detlev Ganten; Ludek Cervenka
Roles of nitric oxide and oxidative stress in the regulation of blood pressure and renal function in prehypertensive Ren-2 transgenic rats.
Kidney & blood pressure research 2005;28(2):117-26.
2005: Ivana Vanecková; Petra Skaroupková; Petr Dvorák; Vera Certíková-Chábová; Vladimír Tesar; Michael Bader; Detlev Ganten; Herbert kramer
Effects of sodium restriction and cyclooxygenase-2 inhibition on the course of hypertension, proteinuria and cardiac hypertrophy in Ren-2 transgenic rats.
Physiological research / Academia Scientiarum Bohemoslovaca 2005;54(1):17-24.
2004: Luciana A Campos; Aurea S Couto; Radu Iliescu; Jerusa A Santos; Robson Augusto Souza Santos; Detlev Ganten; Maria J Campagnole-Santos; Michael Bader; Ovidiu Constantin Baltatu
Differential regulation of central vasopressin receptors in transgenic rats with low brain angiotensinogen.
Regulatory peptides 2004;119(3):177-82.
2004: Elena Popova; Alexander Krivokharchenko; Detlev Ganten; Michael Bader
Efficiency of transgenic rat production is independent of transgene-construct and overnight embryo culture.
Theriogenology 2004;61(7-8):1441-53.
2004: Hao Wang; Bing S Huang; Detlev Ganten; Frans Leenen
Prevention of sympathetic and cardiac dysfunction after myocardial infarction in transgenic rats deficient in brain angiotensinogen.
Circulation research 2004;94(6):843.
2004: Libor Kopkan; Herbert kramer; Zuzana Husková; Zdenka Vanourková; Angela Bäcker; Michael Bader; Detlev Ganten; Ludek Cervenka
Plasma and kidney angiotensin II levels and renal functional responses to AT(1) receptor blockade in hypertensive Ren-2 transgenic rats.
Journal of hypertension 2004;22(4):819-25.
2004: Heike Zimdahl; Gerald Nyakatura; Petra Brandt; Herbert Schulz; Oliver Hummel; Berthold Fartmann; David Brett; Marcus Droege; Jan Monti; Young-Ae Lee; Yinyan Sun; Shaying Zhao; Eitan E Winter; Chris P Ponting; Yuan Chen; Arek Kasprzyk; Ewan Birney; Detlev Ganten; Norbert Hubner
A SNP map of the rat genome generated from cDNA sequences.
Science (New York, N.Y.) 2004;303(5659):807.
2004: Azeez A Aileru; Exazevia Logan; Michael Callahan; Carlos M Ferrario; Detlev Ganten; Debra I Diz
Alterations in sympathetic ganglionic transmission in response to angiotensin II in (mRen2)27 transgenic rats.
Hypertension 2004;43(2):270-5.
2004: Martin Opocenský; Petr Dvorák; Jan Malý; Herbert kramer; Angela Bäcker; Libor Kopkan; Zdena Vernerová; Vladimír Tesar; Tomáš Zima; Michael Bader; Detlev Ganten; J Janda; Ivana Vanecková
Chronic endothelin receptor blockade reduces end-organ damage independently of blood pressure effects in salt-loaded heterozygous Ren-2 transgenic rats.
Physiological research / Academia Scientiarum Bohemoslovaca 2004;53(6):581-93.
2004: Sherry O Kasper; Carlos M Ferrario; Detlev Ganten; Debra I Diz
Central depletion of angiotensinogen is associated with elevated AT1 receptors in the SFO and PVN.
Neurotoxicity research 2004;6(4):259-65.
2004: Petr Dvorák; Herbert kramer; Angela Bäcker; Jan Malý; Libor Kopkan; Ivana Vanecková; Zdena Vernerová; Martin Opocenský; Vladimír Tesar; Michael Bader; Detlev Ganten; Jan Janda; Ludek Cervenka
Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive ren-2 transgenic rats.
Kidney & blood pressure research 2004;27(4):248-58.
2004: Ivana Vanecková; Monika Cahová; Herbert kramer; Zuzana Husková; Petra Skaroupková; Radko Komers; Michael Bader; Detlev Ganten; Ludek Cervenka
Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake.
Kidney & blood pressure research 2004;27(4):203-10.
2003: Eero Mervaala; Piet Finckenberg; Risto Lapatto; Dominik N Müller; Joon-Keun Park; Ralf Dechend; Detlev Ganten; Heikki Vapaatalo; Friedrich C Luft
Lipoic acid supplementation prevents angiotensin II-induced renal injury.
Kidney international 2003;64(2):501-8.
2003: Piet Finckenberg; Kaija Inkinen; Juhani Ahonen; Saara Merasto; Marjut Louhelainen; Heikki Vapaatalo; Dominik Müller; Detlev Ganten; Friedrich Luft; Eero Mervaala
Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways.
The American journal of pathology 2003;163(1):355-66.
2003: Maolian Gong; Hongye Zhang; Herbert Schulz; Young-Ae Lee; Kai Sun; Sylvia Bähring; Friedrich C Luft; Peter Nürnberg; André Reis; Klaus Rohde; Detlev Ganten; Rutai Hui; Norbert Hübner
Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p.
Human molecular genetics 2003;12(11):1273-7.
2003: Jan Monti; Heike Zimdahl; Herbert Schulz; Ralph Plehm; Detlev Ganten; Norbert Hübner
The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10.
Hypertension 2003;41(4):938-42.
2003: Alexander Krivokharchenko; Elena Popova; Ioulia Zaitseva; Larissa Vil'ianovich; Detlev Ganten; Michael Bader
Development of parthenogenetic rat embryos.
Biology of reproduction 2003;68(3):829-36.
2003: Jan Monti; Ralph Plehm; Herbert Schulz; Detlev Ganten; Reinhold Kreutz; Norbert Hübner
Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10.
Human molecular genetics 2003;12(4):435-9.
2003: Chana Yagil; Norbert Hubner; Reinhold Kreutz; Detlev Ganten; Yoram Yagil
Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension.
Physiological genomics 2003;12(2):85-95.
2002: Detlev Ganten
How to deal with scientific controversy?
Journal of molecular medicine (Berlin, Germany) 2002;80(12):745-6.
2002: Elena Popova; Alexander Krivokharchenko; Detlev Ganten; Michael Bader
Comparison between PMSG- and FSH-induced superovulation for the generation of transgenic rats.
Molecular reproduction and development 2002;63(2):177-82.
2002: Ningling Kang; Thomas Walther; Xiao-Li Tian; Jürgen Bohlender; Akiyoshi Fukamizu; Detlev Ganten; Michael Bader
Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis.
Journal of molecular medicine (Berlin, Germany) 2002;80(6):359-66.
2002: Heike Zimdahl; Thomas Kreitler; Claudia Gösele; Detlev Ganten; Norbert Hübner
Conserved synteny in rat and mouse for a blood pressure QTL on human chromosome 17.
Hypertension 2002;39(6):1050-2.
2002: Aurea S Couto; Ovidiu Constantin Baltatu; Robson Augusto Souza Santos; Detlev Ganten; Michael Bader; Maria J Campagnole-Santos
Differential effects of angiotensin II and angiotensin-(1-7) at the nucleus tractus solitarii of transgenic rats with low brain angiotensinogen.
Journal of hypertension 2002;20(5):919-25.
2002: Detlev Ganten
Friedrich Cameron Luft turns 60: bridging the New and the Old World.
Journal of molecular medicine (Berlin, Germany) 2002;80(4):197-9.
2002: Alexander Krivokharchenko; Vassili Galat; Detlev Ganten; Michael Bader
In vitro formation of tetraploid rat blastocysts after fusion of two-cell embryos.
Molecular reproduction and development 2002;61(4):460-5.
2002: Fred Fändrich; Xiongbin Lin; Gui X Chai; Maren Schulze; Detlev Ganten; Michael Bader; Julia Holle; Dong-Sheng Huang; Reza Parwaresch; Nicholas Zavazava; Bert Binas
Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning.
Nature medicine 2002;8(2):171-8.
2002: Michael Bader; Detlev Ganten
It's renin in the brain: transgenic animals elucidate the brain renin angiotensin system.
Circulation research 2002;90(1):8-10.
2002: Ludek Cervenka; Herbert kramer; Jan Malý; Ivana Vanecková; Angela Bäcker; Dirk Bokemeyer; Michael Bader; Detlev Ganten; Kenneth D Mitchell
Role of nNOS in regulation of renal function in hypertensive Ren-2 transgenic rats.
Physiological research / Academia Scientiarum Bohemoslovaca 2002;51(6):571-80.
2002: Juergen Theuer; Ralf Dechend; Dominik N Muller; Joon-Keun Park; Anette Fiebeler; Peter Barta; Detlev Ganten; Hermann Haller; Rainer Dietz; Friedrich C Luft
Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats.
BMC cardiovascular disorders 2002;2():3.
2001: Sigrid Hoffmann; T Krause; Peter P van Geel; Roland Willenbrock; Ines Pagel; Yigal M Pinto; Hendrik Buikema; Wiek H van Gilst; Carsten Lindschau; Martin Paul; T Inagami; Detlev Ganten; H Urata
Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy.
Journal of molecular medicine (Berlin, Germany) 2001;79(10):601-8.
2001: Dominik N Muller; Vigo Heissmeyer; Ralf Dechend; Franziska Hampich; Joon-Keun Park; Anette Fiebeler; Erdenechimeg Shagdarsuren; Juergen Theuer; Marlies Elger; Bernhard Pilz; V Breu; K Schroer; Detlev Ganten; Rainer Dietz; Hermann Haller; Claus Scheidereit; Friedrich C Luft
Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(10):1822-4.
2001: Michael Bader; J Peters; Ovidiu Constantin Baltatu; Dominik N Müller; Friedrich C Luft; Detlev Ganten
Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research.
Journal of molecular medicine (Berlin, Germany) 2001;79(2-3):76-102.
2001: Bing S Huang; Detlev Ganten; Frans Leenen
Responses to central Na(+) and ouabain are attenuated in transgenic rats deficient in brain angiotensinogen.
Hypertension 2001;37(2 Pt 2):683-6.
2001: Eero Mervaala; Zhong Jian Cheng; Ilkka Tikkanen; Risto Lapatto; K Nurminen; Heikki Vapaatalo; Dominik N Müller; Anette Fiebeler; U Ganten; Detlev Ganten; Friedrich C Luft
Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes.
Hypertension 2001;37(2 Pt 2):414-8.
2001: Ovidiu Constantin Baltatu; B J Janssen; G Bricca; Ralph Plehm; Jan Monti; Detlev Ganten; Michael Bader
Alterations in blood pressure and heart rate variability in transgenic rats with low brain angiotensinogen.
Hypertension 2001;37(2 Pt 2):408-13.
2001: Ovidiu Constantin Baltatu; Marco Antônio Peliky Fontes; Maria J Campagnole-Santos; S Caligiorni; Detlev Ganten; Robson Augusto Souza Santos; Michael Bader
Alterations of the renin-angiotensin system at the RVLM of transgenic rats with low brain angiotensinogen.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(2):R428-33.
2001: Anita C Hansson; Wolfgang Sommer; Beth Andbjer; Michael Bader; Detlev Ganten; Kjell Fuxe
Induction of hippocampal glial cells expressing basic fibroblast growth factor RNA by corticosterone.
Neuroreport 2001;12(1):141-5.
2001: Jan Monti; M Schinke; M Böhm; Detlev Ganten; Michael Bader; G Bricca
Glial angiotensinogen regulates brain angiotensin II receptors in transgenic rats TGR(ASrAOGEN).
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(1):R233-40.
2000: Claudia Gösele; L Hong; Thomas Kreitler; M Rossmann; B Hieke; U Gross; M Kramer; Heinz Himmelbauer; M T Bihoreau; AE Kwitek-Black; Simon N Twigger; Peter Tonellato; H J Jacob; Leonard C Schalkwyk; Klaus Lindpaintner; Detlev Ganten; Hans Lehrach; Margit Knoblauch
High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers.
Genomics 2000;69(3):287-94.
2000: Jürgen Bohlender; Detlev Ganten; Friedrich C Luft
Rats transgenic for human renin and human angiotensinogen as a model for gestational hypertension.
Journal of the American Society of Nephrology : JASN 2000;11(11):2056-61.
2000: Jose Silva Junior; Ronaldo C Araujo; Ovidiu Constantin Baltatu; S M Oliveira; Carsten Tschöpe; E Fink; Sigrid Hoffmann; Ralph Plehm; K X Chai; Lee Chao; Julie Chao; Detlev Ganten; João B Pesquero; Michael Bader
Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):1858-60.
2000: Joon-Keun Park; Dominik N Müller; Eero Mervaala; Ralf Dechend; Anette Fiebeler; F Schmidt; M Bieringer; O Schäfer; Carsten Lindschau; W Schneider; Detlev Ganten; Friedrich C Luft; Hermann Haller
Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects.
Kidney international 2000;58(4):1420-30.
2000: Anita C Hansson; A Cintra; Natale Belluardo; Wolfgang Sommer; M Bhatnagar; Michael Bader; Detlev Ganten; Kjell Fuxe
Gluco- and mineralocorticoid receptor-mediated regulation of neurotrophic factor gene expression in the dorsal hippocampus and the neocortex of the rat.
The European journal of neuroscience 2000;12(8):2918-34.
2000: Dominik N Muller; Eero Mervaala; F Schmidt; Joon-Keun Park; Ralf Dechend; E Genersch; V Breu; Bernd-Michael Löffler; Detlev Ganten; W Schneider; Hermann Haller; Friedrich C Luft
Effect of bosentan on NF-kappaB, inflammation, and tissue factor in angiotensin II-induced end-organ damage.
Hypertension 2000;36(2):282-90.
2000: Dominik N Müller; Eero Mervaala; Ralf Dechend; Anette Fiebeler; Joon-Keun Park; F Schmidt; Juergen Theuer; V Breu; Nigel Mackman; T Luther; W Schneider; DC Gulba; Detlev Ganten; Hermann Haller; Friedrich C Luft
Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy.
The American journal of pathology 2000;157(1):111-22.
2000: Marco Antônio Peliky Fontes; Ovidiu Constantin Baltatu; Sordaini Caligiorne; Maria J Campagnole-Santos; Detlev Ganten; Michael Bader; Robson Augusto Souza Santos
Angiotensin peptides acting at rostral ventrolateral medulla contribute to hypertension of TGR(mREN2)27 rats.
Physiological genomics 2000;2(3):137-42.
2000: Jürgen Bohlender; Joël Ménard; Detlev Ganten; Friedrich C Luft
Angiotensinogen concentrations and renin clearance : implications for blood pressure regulation.
Hypertension 2000;35(3):780-6.
2000: Eero Mervaala; Dominik N Müller; F Schmidt; Joon-Keun Park; Volkmar Gross; M Bader; V Breu; Detlev Ganten; Hermann Haller; Friedrich C Luft
Blood pressure-independent effects in rats with human renin and angiotensinogen genes.
Hypertension 2000;35(2):587-94.
2000: Claudia Gösele; Frank Grützner; João B Pesquero; Jose Silva Junior; T Junge; Detlev Ganten; Michael Bader; Margit Knoblauch
Assignment of the kinin receptor B1 and B2 genes (Bdkrb1 and Bdkrb2) to rat chromosome 6q3.2 by FISH and radiation hybrid mapping.
Cytogenetics and cell genetics 2000;89(1-2):51-2.
2000: Michael Bader; Detlev Ganten
Regulation of renin: new evidence from cultured cells and genetically modified mice.
Journal of molecular medicine (Berlin, Germany) 2000;78(3):130-9.
2000: Ovidiu Constantin Baltatu; Jose Silva Junior; Detlev Ganten; Michael Bader
The brain renin-angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy.
Hypertension 2000;35(1 Pt 2):409-12.
2000: Eero Mervaala; Dominik N Müller; Joon-Keun Park; Ralf Dechend; F Schmidt; Anette Fiebeler; M Bieringer; V Breu; Detlev Ganten; Hermann Haller; Friedrich C Luft
Cyclosporin A protects against angiotensin II-induced end-organ damage in double transgenic rats harboring human renin and angiotensinogen genes.
Hypertension 2000;35(1 Pt 2):360-6.
2000: Dominik N Muller; Ralf Dechend; Eero Mervaala; Joon-Keun Park; F Schmidt; Anette Fiebeler; Juergen Theuer; V Breu; Detlev Ganten; Hermann Haller; Friedrich C Luft
NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats.
Hypertension 2000;35(1 Pt 2):193-201.
1999: Norbert Hübner; Y A Lee; Klaus Lindpaintner; Detlev Ganten; Reinhold Kreutz
Congenic substitution mapping excludes Sa as a candidate gene locus for a blood pressure quantitative trait locus on rat chromosome 1.
Hypertension 1999;34(4 Pt 1):643-8.
1999: E Mervaala; B Dehmel; V Gross; Andrea Lippoldt; Jürgen Bohlender; Anna Franca Milia; Detlev Ganten; F C Luft
Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin and angiotensinogen genes.
Journal of the American Society of Nephrology : JASN 1999;10(8):1669-80.
1999: M Schinke; Ovidiu Constantin Baltatu; M Böhm; J Peters; W Rascher; G Bricca; Andrea Lippoldt; Detlev Ganten; Michael Bader
Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3975-80.
1999: William B Strawn; Patricia E Gallagher; E Ann Tallant; Detlev Ganten; Carlos M Ferrario
Angiotensin II AT1-receptor blockade inhibits monocyte activation and adherence in transgenic (mRen2)27 rats.
Journal of cardiovascular pharmacology 1999;33(3):341-51.
1999: Eero Mervaala; Dominik N Müller; Joon-Keun Park; F Schmidt; M Löhn; V Breu; Duska Dragun; Detlev Ganten; Hermann Haller; Friedrich C Luft
Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension.
Hypertension 1999;33(1 Pt 2):389-95.
1999: T Nishioka; Michael F Callahan; P Li; Carlos M Ferrario; Detlev Ganten; M Morris
Increased central angiotensin and osmotic responses in the Ren-2 transgenic rat.
Hypertension 1999;33(1 Pt 2):385-8.
1999: T Voigtländer; Detlev Ganten; Michael Bader
Transcriptional regulation of the rat renin gene by regulatory elements in intron I.
Hypertension 1999;33(1 Pt 2):303-11.
1999: Chana Yagil; Marina Sapojnikov; Reinhold Kreutz; Heiko Zürcher; Detlev Ganten; Yoram Yagil
Role of chromosome X in the Sabra rat model of salt-sensitive hypertension.
Hypertension 1999;33(1 Pt 2):261-5.
1999: Friedrich C Luft; Eero Mervaala; Dominik N Müller; Volkmar Gross; F Schmidt; Joon-Keun Park; C Schmitz; Andrea Lippoldt; V Breu; Ralf Dechend; Duska Dragun; W Schneider; Detlev Ganten; Hermann Haller
Hypertension-induced end-organ damage : A new transgenic approach to an old problem.
Hypertension 1999;33(1 Pt 2):212-8.
1998: B Dehmel; E Mervaala; Andrea Lippoldt; V Gross; Jürgen Bohlender; Detlev Ganten; F C Luft
Pressure-natriuresis and -diuresis in transgenic rats harboring both human renin and human angiotensinogen genes.
Journal of the American Society of Nephrology : JASN 1998;9(12):2212-22.
1998: H Nishimura; H Buikema; Ovidiu Constantin Baltatu; Detlev Ganten; H Urata
Functional evidence for alternative ANG II-forming pathways in hamster cardiovascular system.
The American journal of physiology 1998;275(4 Pt 2):H1307-12.
1998: P Li; M Morris; Carlos M Ferrario; C Barrett; Detlev Ganten; Michael F Callahan
Cardiovascular, endocrine, and body fluid-electrolyte responses to salt loading in mRen-2 transgenic rats.
The American journal of physiology 1998;275(4 Pt 2):H1130-7.
1998: K Yamada; SN Iyer; Mark C Chappell; Detlev Ganten; Carlos M Ferrario
Converting enzyme determines plasma clearance of angiotensin-(1-7).
Hypertension 1998;32(3):496-502.
1998: K Sugimura; X L Tian; Sigrid Hoffmann; Detlev Ganten; Michael Bader
Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization.
Biochemical and biophysical research communications 1998;247(2):466-72.
1998: Jürgen Bohlender; Joël Ménard; O Edling; Detlev Ganten; Friedrich C Luft
Mouse and rat plasma renin concentration and gene expression in (mRen2)27 transgenic rats.
The American journal of physiology 1998;274(5 Pt 2):H1450-6.
1998: Ovidiu Constantin Baltatu; Andrea Lippoldt; A Hansson; Detlev Ganten; Michael Bader
Local renin-angiotensin system in the pineal gland.
Brain research. Molecular brain research 1998;54(2):237-42.
1998: T Nishioka; M Morris; P Li; Detlev Ganten; Carlos M Ferrario; Michael F Callahan
Depressor role of angiotensin AT2 receptors in the (mRen-2)27 transgenic rat.
American journal of hypertension 1998;11(3 Pt 1):357-62.
1998: J Wagner; Marek Drab; Jürgen Bohlender; K Amann; W Wienen; Detlev Ganten
Effects of AT1 receptor blockade on blood pressure and the renin-angiotensin system in spontaneously hypertensive rats of the stroke prone strain.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1998;20(2):205-21.
1998: Dominik N Müller; Walter Fischli; Jean-Paul Clozel; Karl F Hilgers; Jürgen Bohlender; Joël Ménard; Andreas Busjahn; Detlev Ganten; Friedrich C Luft
Local angiotensin II generation in the rat heart: role of renin uptake.
Circulation research 1998;82(1):13-20.
1998: Debra I Diz; Brian Westwood; Susan M Bosch; Detlev Ganten; Carlos M Ferrario
NK1 receptor antagonist blocks angiotensin II responses in renin transgenic rat medulla oblongata.
Hypertension 1998;31(1 Pt 2):473-9.
1998: Chana Yagil; Marina Sapojnikov; Reinhold Kreutz; G Katni; Klaus Lindpaintner; Detlev Ganten; Yoram Yagil
Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension.
Hypertension 1998;31(1):119-24.
1997: K B Brosnihan; P Li; Detlev Ganten; Carlos M Ferrario
Estrogen protects transgenic hypertensive rats by shifting the vasoconstrictor-vasodilator balance of RAS.
The American journal of physiology 1997;273(6 Pt 2):R1908-15.
1997: S N Yang; A Lippoldt; Anders Jansson; M I Phillips; Detlev Ganten; Kjell Fuxe
Localization of angiotensin II AT1 receptor-like immunoreactivity in catecholaminergic neurons of the rat medulla oblongata.
Neuroscience 1997;81(2):503-15.
1997: P Li; Carlos M Ferrario; Detlev Ganten; K Bridget Brosnihan
Chronic estrogen treatment in female transgenic (mRen2)27 hypertensive rats augments endothelium-derived nitric oxide release.
American journal of hypertension 1997;10(6):662-70.
1997: S N Yang; D R Fior; Anita C Hansson; A Cintra; M Castellano; U Ganten; Detlev Ganten; Luigi F Agnati; Kjell Fuxe
Increased potency of neuropeptide Y to antagonize alpha2-adrenoceptor function in the nucleus tractus solitarii of the spontaneously hypertensive rat.
Neuroscience 1997;78(3):803-13.
1997: Jürgen Bohlender; Joël Ménard; Friedrich C Luft; Detlev Ganten
Dose effects of human renin in rats transgenic for human angiotensinogen.
Hypertension 1997;29(4):1031-8.
1997: Ovidiu Constantin Baltatu; H Nishimura; S Hoffmann; G Stoltenburg; I D Haulica; Andrea Lippoldt; Detlev Ganten; H Urata
High levels of human chymase expression in the pineal and pituitary glands.
Brain research 1997;752(1-2):269-78.
1997: Debra I Diz; B Falgui; Susan M Bosch; Brian Westwood; J Kent; Detlev Ganten; Carlos M Ferrario
Hypothalamic substance P release. Attenuated angiotensin responses in mRen2(27) transgenic rats.
Hypertension 1997;29(1 Pt 2):510-3.
1997: Jürgen Bohlender; Akiyoshi Fukamizu; Andrea Lippoldt; T Nomura; R Dietz; Joël Ménard; K Murakami; F C Luft; Detlev Ganten
High human renin hypertension in transgenic rats.
Hypertension 1997;29(1 Pt 2):428-34.
1997: Reinhold Kreutz; Berthold Struk; S Rubattu; Norbert Hübner; J Szpirer; Claude Szpirer; Detlev Ganten; Klaus Lindpaintner
Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension.
Hypertension 1997;29(1 Pt 1):131-6.
1997: William B Strawn; P Gallagher; Richard H Dean; Detlev Ganten; Carlos M Ferrario
Endothelial injury in transgenic (mRen-2)27 hypertensive rats.
American journal of hypertension 1997;10(1):51-7.
1996: B Erdmann; Kjell Fuxe; Detlev Ganten
Subcellular localization of angiotensin II immunoreactivity in the rat cerebellar cortex.
Hypertension 1996;28(5):818-24.
1996: Michael Böhm; Andrea Lippoldt; W Wienen; Detlev Ganten; Michael Bader
Reduction of cardiac hypertrophy in TGR(mREN2)27 by angiotensin II receptor blockade.
Molecular and cellular biochemistry 1996;163-164():217-21.
1996: Chana Yagil; G Katni; Speranza Rubattu; C Stolpe; Reinhold Kreutz; Klaus Lindpaintner; Detlev Ganten; D Ben-Ishay; Yoram Yagil
Development, genotype and phenotype of a new colony of the Sabra hypertension prone (SBH/y) and resistant (SBN/y) rat model of slat sensitivity and resistance.
Journal of hypertension 1996;14(10):1175-82.
1996: B Erdmann; H Gerst; Andrea Lippoldt; Hannes Buelow; Detlev Ganten; Kjell Fuxe; Rita Bernhardt
Expression of cytochrome P45011B1 mRNA in the brain of normal and hypertensive transgenic rats.
Brain research 1996;733(1):73-82.
1996: Michael Bader; Detlev Ganten
Transgenic rats: tools to study the function of the renin-angiotensin system.
Clinical and experimental pharmacology & physiology 1996;23 Suppl 3():S81-7.
1996: S Schmidt; R Giessel; KH Bergis; K Strojek; W Grzeszczak; Detlev Ganten; Eberhard Ritz
Angiotensinogen gene M235T polymorphism is not associated with diabetic nephropathy. The Diabetic Nephropathy Study Group.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11(9):1755-61.
1996: Andrea Lippoldt; Beth Andbjer; H Gerst; Detlev Ganten; Kjell Fuxe
Basic fibroblast growth factor expression and tenascin C immunoreactivity after partial unilateral hemitransection of the rat brain.
Brain research 1996;730(1-2):1-16.
1996: J Bohlender; J Ménard; J Wagner; Friedrich C Luft; Detlev Ganten
[Development of a model of human renin hypertension in rats].
Archives des maladies du coeur et des vaisseaux 1996;89(8):1009-11.
1996: M A Lee; Michael Böhm; Martin Paul; Michael Bader; U Ganten; Detlev Ganten
Physiological characterization of the hypertensive transgenic rat TGR(mREN2)27.
The American journal of physiology 1996;270(6 Pt 1):E919-29.
1996: H Nishimura; Sigrid Hoffmann; Ovidiu Constantin Baltatu; K Sugimura; Detlev Ganten; H Urata
Angiotensin I converting enzyme and chymase in cardiovascular tissues.
Kidney international. Supplement 1996;55():S18-23.
1996: P Li; M Morris; Debra I Diz; Carlos M Ferrario; Detlev Ganten; Michael F Callahan
Role of paraventricular angiotensin AT1 receptors in salt-sensitive hypertension in mRen-2 transgenic rats.
The American journal of physiology 1996;270(5 Pt 2):R1178-81.
1996: M Langheinrich; M A Lee; M Böhm; Y M Pinto; Detlev Ganten; Martin Paul
The hypertensive Ren-2 transgenic rat TGR (mREN2)27 in hypertension research. Characteristics and functional aspects.
American journal of hypertension 1996;9(5):506-12.
1996: H Urata; H Nishimura; Detlev Ganten
Chymase-dependent angiotensin II forming systems in humans.
American journal of hypertension 1996;9(3):277-84.
1996: David B Averill; K Matsumura; Detlev Ganten; Carlos M Ferrario
Role of area postrema in transgene hypertension.
Hypertension 1996;27(3 Pt 2):591-7.
1996: Michael F Callahan; P Li; Carlos M Ferrario; Detlev Ganten; M Morris
Salt-sensitive hypertension in (mREN-2)27 transgenic rats.
Hypertension 1996;27(3 Pt 2):573-7.
1996: J Bohlender; J Ménard; J Wagner; Friedrich C Luft; Detlev Ganten
Human renin-dependent hypertension in rats transgenic for human angiotensinogen.
Hypertension 1996;27(3 Pt 2):535-40.
1996: M Schinke; Michael Böhm; G Bricca; Detlev Ganten; Michael Bader
Permanent inhibition of angiotensinogen synthesis by antisense RNA expression.
Hypertension 1996;27(3 Pt 2):508-13.
1996: V Gross; Andrea Lippoldt; Jürgen Bohlender; Detlev Ganten; U Ganten; Friedrich C Luft
The renin-angiotensin system and renal function in transgenic (mRen2)27 rats.
Experimental nephrology 1996;4 Suppl 1():20-6.
1996: H Urata; H Nishimura; Detlev Ganten; K Arakawa
Angiotensin-converting enzyme-independent pathways of angiotensin II formation in human tissues and cardiovascular diseases.
Blood pressure. Supplement 1996;2():22-8.
1996: R Kreutz; M S Fernandez-Alfonso; Detlev Ganten; Martin Paul
Effect of losartan on right ventricular hypertrophy and cardiac angiotensin I-converting enzyme activity in pulmonary hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1996;18(1):101-11.
1995: H Urata; H Nishimura; Detlev Ganten
Mechanisms of angiotensin II formation in humans.
European heart journal 1995;16 Suppl N():79-85.
1995: Reinhold Kreutz; Norbert Hübner; Detlev Ganten; Klaus Lindpaintner
Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure. A quantitative trait locus confers identical complex phenotypes in human and rat hypertension.
Circulation 1995;92(9):2381-4.
1995: Norbert Hübner; Reinhold Kreutz; Speranza Rubattu; Y A Lee; Detlev Ganten; P D Allen; Klaus Lindpaintner
The gene encoding endothelial nitric oxide synthase, Nos3, maps to rat chromosome 4.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(10):758-9.
1995: Detlev Ganten; J Pötzsch
The World Hypertension League: goals and perspectives.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1995;17(7):1079-89.
1995: Reinhold Kreutz; Norbert Hübner; M R James; Marie-Thérèse Bihoreau; Dominique Gauguier; G M Lathrop; Detlev Ganten; Klaus Lindpaintner
Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8778-82.
1995: Norbert Hübner; Reinhold Kreutz; S Takahashi; Detlev Ganten; Klaus Lindpaintner
Altered angiotensinogen amino acid sequence and plasma angiotensin II levels in genetically hypertensive rats. A study on cause and effect.
Hypertension 1995;26(2):279-84.
1995: Dominik N Müller; K F Hilgers; Jürgen Bohlender; Andrea Lippoldt; J Wagner; Walter Fischli; Detlev Ganten; Johannes F E Mann; Friedrich C Luft
Effects of human renin in the vasculature of rats transgenic for human angiotensinogen.
Hypertension 1995;26(2):272-8.
1995: A Moriguchi; E Ann Tallant; K Matsumura; T M Reilly; H Walton; Detlev Ganten; Carlos M Ferrario
Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats.
Hypertension 1995;25(6):1260-5.
1995: B Djavidani; M Sander; R Kreutz; K Zeh; Michael Bader; Synthia H Mellon; P Vecsei; J Peters; Detlev Ganten
Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mREN2)27.
Journal of hypertension 1995;13(6):637-45.
1995: J Wagner; A Wystrychowski; H Stauss; Detlev Ganten; Eberhard Ritz
Decreased renal haemodynamic response to inhibition of nitric oxide synthase in subtotally nephrectomized rats.
Pflügers Archiv : European journal of physiology 1995;430(2):181-7.
1995: D R Fior; S N Yang; U Ganten; Detlev Ganten; Kjell Fuxe
Evidence for a differential modulation of the alpha-2 adrenoceptors by angiotensin II in the nucleus tractus solitarii of the spontaneously hypertensive and the Wistar-Kyoto normotensive rats.
Brain research 1995;679(1):168-77.
1995: J Wagner; F Thiele; Detlev Ganten
Transgenic animals as models for human disease.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1995;17(4):593-605.
1995: R Kreutz; M S Fernandez-Alfonso; Y Liu; Detlev Ganten; Martin Paul
Induction of cardiac angiotensin I-converting enzyme with dietary NaCl-loading in genetically hypertensive and normotensive rats.
Journal of molecular medicine (Berlin, Germany) 1995;73(5):243-8.
1995: M A Lee; Michael Böhm; S Kim; S Bachmann; J Bachmann; Michael Bader; Detlev Ganten
Differential gene expression of renin and angiotensinogen in the TGR(mREN-2)27 transgenic rat.
Hypertension 1995;25(4 Pt 1):570-80.
1995: C Klett; Michael Bader; M Schwemmle; Detlev Ganten; E Hackenthal
Contribution of a 12 kDa protein to the angiotensin II-induced stabilization of angiotensinogen mRNA: interaction with the 3' untranslated mRNA.
Journal of molecular endocrinology 1995;14(2):209-26.
1995: C Keuneke; R Yacullo; M Sugiura; G Mall; R Metzger; Detlev Ganten
Converting enzyme inhibitors differentially affect expression of genes of the renin-angiotensin system.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1995;17(3):551-74.
1995: Synthia H Mellon; Nathalie A Compagnone; M Sander; C Cover; Detlev Ganten; B Djavidani
Rodent models for studying steroids and hypertension: from fetal development to cells in culture.
Steroids 1995;60(1):59-64.
1995: Andrea Lippoldt; Martin Paul; Kjell Fuxe; Detlev Ganten
The brain renin-angiotensin system: molecular mechanisms of cell to cell interactions.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1995;17(1-2):251-66.
1995: P Stock; Lutz Liefeldt; Martin Paul; Detlev Ganten
Local renin-angiotensin systems in cardiovascular tissues: localization and functional role.
Cardiology 1995;86 Suppl 1():2-8.
1995: S Schmidt; Arya Sharma; O Zilch; Joachim Beige; M Walla-Friedel; Detlev Ganten; Armin Distler; Eberhard Ritz
Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995;10(7):1145-8.
1994: Andrea Lippoldt; B Bunnemann; A Ueki; L Rosén; A Cintra; U Hasselrot; R Metzger; Ulrich Hilgenfeldt; B Brosnihan; Detlev Ganten
On the plasticity of the cerebellar renin-angiotensin system: localization of components and effects of mechanical perturbation.
Brain research 1994;668(1-2):144-59.
1994: H Urata; Sigrid Hoffmann; Detlev Ganten
Tissue angiotensin II system in the human heart.
European heart journal 1994;15 Suppl D():68-78.
1994: Martin Paul; Yigal M Pinto; Heribert Schunkert; Detlev Ganten; Michael Böhm
Activation of the renin-angiotensin system in heart failure and hypertrophy--studies in human hearts and transgenic rats.
European heart journal 1994;15 Suppl D():63-7.
1994: H Urata; F Strobel; Detlev Ganten
Widespread tissue distribution of human chymase.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1994;12(9):S17-22.
1994: A Moriguchi; Carlos M Ferrario; K Bridget Brosnihan; Detlev Ganten; M Morris
Differential regulation of central vasopressin in transgenic rats harboring the mouse Ren-2 gene.
The American journal of physiology 1994;267(3 Pt 2):R786-91.
1994: M S Fernández-Alfonso; R Kreutz; K Zeh; Y Liu; Detlev Ganten; Martin Paul
Differential regulation of vascular angiotensin I-converting enzyme in hypertension.
Hypertension 1994;24(3):280-6.
1994: K Bridget Brosnihan; A Moriguchi; H Nakamoto; Richard H Dean; Detlev Ganten; Carlos M Ferrario
Estrogen augments the contribution of nitric oxide to blood pressure regulation in transgenic hypertensive rats expressing the mouse Ren-2 gene.
American journal of hypertension 1994;7(7 Pt 1):576-82.
1994: Norbert Hübner; Reinhold Kreutz; S Takahashi; Detlev Ganten; Klaus Lindpaintner
Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows no linkage to the angiotensinogen locus.
Hypertension 1994;23(6 Pt 1):797-801.
1994: A Moriguchi; K Bridget Brosnihan; H Kumagai; Detlev Ganten; Carlos M Ferrario
Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene.
The American journal of physiology 1994;266(4 Pt 2):R1273-9.
1994: M Sander; Detlev Ganten; Synthia H Mellon
Role of adrenal renin in the regulation of adrenal steroidogenesis by corticotropin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):148-52.
1994: C Klett; Michael Bader; Detlev Ganten; E Hackenthal
Mechanism by which angiotensin II stabilizes messenger RNA for angiotensinogen.
Hypertension 1994;23(1 Suppl):I120-5.
1994: Detlev Ganten; S Schmidt; Martin Paul
Genetics of primary hypertension.
Journal of cardiovascular pharmacology 1994;24 Suppl 3():S45-50.
1993: A Ciechanowicz; Michael Bader; Juergen Wagner; Detlev Ganten
Extra-hepatic transcription of plasma prekallikrein gene in human and rat tissues.
Biochemical and biophysical research communications 1993;197(3):1370-6.
1993: Thomas Unger; Detlev Ganten; C I Johnston; A F Lever; J J Mullins; J Sassard; P A van Zwieten
Round table 1. Do transgenic techniques help us to understand hypertension?
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1993;11(5):S374-9.
1993: J Bachmann; Juergen Wagner; C Haufe; A Wystrychowski; A Ciechanowicz; Detlev Ganten
Modulation of blood pressure and the renin-angiotensin system in transgenic and spontaneously hypertensive rats afer ovariectomy.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1993;11(5):S226-7.
1993: H Urata; Detlev Ganten
Cardiac angiotensin II formation: the angiotensin-I converting enzyme and human chymase.
European heart journal 1993;14 Suppl I():177-82.
1993: Juergen Wagner; Detlev Ganten
The renin-angiotensin system in transgenic rats: characteristics and functional studies.
Seminars in nephrology 1993;13(6):586-92.
1993: Y Zhao; Michael Bader; R Kreutz; M Fernandez-Alfonso; F Zimmermann; U Ganten; R Metzger; Detlev Ganten; J J Mullins; Jörg Peters
Ontogenetic regulation of mouse Ren-2d renin gene in transgenic hypertensive rats, TGR(mREN2)27.
The American journal of physiology 1993;265(5 Pt 1):E699-707.
1993: Andrea Lippoldt; Beth Andbjer; L Rosén; E Richter; Detlev Ganten; Y Cao; R F Pettersson; Kjell Fuxe
Photochemically induced focal cerebral ischemia in rat: time dependent and global increase in expression of basic fibroblast growth factor mRNA.
Brain research 1993;625(1):45-56.
1993: Y Zhao; J Peters; Detlev Ganten; M Bader
Expression of the mouse ren-2 gene in the small intestine is regulated by food intake.
Pflügers Archiv : European journal of physiology 1993;424(3-4):199-202.
1993: C Klett; W Hellmann; E Hackenthal; Detlev Ganten
Modulation of tissue angiotensinogen gene expression by glucocorticoids, estrogens, and androgens in SHR and WKY rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1993;15(4):683-708.
1993: M A Lee; Michael Böhm; Martin Paul; Detlev Ganten
Tissue renin-angiotensin systems. Their role in cardiovascular disease.
Circulation 1993;87(5 Suppl):IV7-13.
1993: C Klett; W Hellmann; Detlev Ganten; E Hackenthal
Tissue distribution of angiotensinogen mRNA during experimental inflammation.
Inflammation 1993;17(2):183-97.
1993: S Schmidt; I M van Hooft; Diederick Grobbee; Detlev Ganten; Eberhard Ritz
Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study.
Journal of hypertension 1993;11(4):345-8.
1993: Jörg Peters; Klaus Münter; Michael Bader; E Hackenthal; J J Mullins; Detlev Ganten
Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium.
The Journal of clinical investigation 1993;91(3):742-7.
1993: Andrea Lippoldt; B Bunnemann; N Iwai; R Metzger; T Inagami; Kjell Fuxe; Detlev Ganten
Cellular localization of angiotensin type 1 receptor and angiotensinogen mRNAs in the subfornical organ of the rat brain.
Neuroscience letters 1993;150(2):153-8.
1993: Klaus Lindpaintner; W Lu; N Neidermajer; B Schieffer; H Just; Detlev Ganten; H Drexler
Selective activation of cardiac angiotensinogen gene expression in post-infarction ventricular remodeling in the rat.
Journal of molecular and cellular cardiology 1993;25(2):133-43.
1993: Detlev Ganten
The transition from experimental to clinical pharmacology: the renin-angiotensin paradigm.
Journal of cardiovascular pharmacology 1993;22 Suppl 1():S14-29.
1992: Detlev Ganten; Juergen Wagner; K Zeh; Michael Bader; J B Michel; Martin Paul; F Zimmermann; P Ruf; Ulrich Hilgenfeldt; U Ganten
Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7806-10.
1992: M Sander; Michael Bader; B Djavidani; Christiane Maser-Gluth; P Vecsei; J Mullins; Detlev Ganten; Jörg Peters
The role of the adrenal gland in hypertensive transgenic rat TGR(mREN2)27.
Endocrinology 1992;131(2):807-14.
1992: C Klett; Detlev Ganten; W Hellmann; M Kaling; Gerhart U Ryffel; T Weimar-Ehl; E Hackenthal
Regulation of hepatic angiotensinogen synthesis and secretion by steroid hormones.
Endocrinology 1992;130(6):3660-8.
1992: Michael Bader; Y Zhao; M Sander; M A Lee; J Bachmann; Michael Böhm; B Djavidani; Jörg Peters; J J Mullins; Detlev Ganten
Role of tissue renin in the pathophysiology of hypertension in TGR(mREN2)27 rats.
Hypertension 1992;19(6 Pt 2):681-6.
1992: Martin Paul; Jeannine Bachmann; Detlev Ganten
The tissue renin-angiotensin systems in cardiovascular disease.
Trends in cardiovascular medicine 1992;2(3):94-9.
1992: S Kimura; J J Mullins; B Bunnemann; R Metzger; Ulrich Hilgenfeldt; F Zimmermann; H Jacob; Kjell Fuxe; Detlev Ganten; M Kaling
High blood pressure in transgenic mice carrying the rat angiotensinogen gene.
The EMBO journal 1992;11(3):821-7.
1992: R Kreutz; M Higuchi; Detlev Ganten
Molecular genetics of hypertension.
Clinical and experimental hypertension. Part A, Theory and practice 1992;14(1-2):15-34.
1992: Martin Paul; Detlev Ganten
The molecular basis of cardiovascular hypertrophy: the role of the renin-angiotensin system.
Journal of cardiovascular pharmacology 1992;19 Suppl 5():S51-8.
1992: Michael Bader; M Kaling; R Metzger; J Peters; Juergen Wagner; Detlev Ganten
Basic methodology in the molecular characterization of genes.
Journal of hypertension 1992;10(1):9-16.
1991: K Adler; P Boels; U Ganten; Detlev Ganten; Ingo Morano
The influence of cold stress on the myosin heavy chain expression of cardiac and smooth muscle in normotensive and spontaneously hypertensive female rats.
Circulation research 1991;69(6):1640-4.
1991: Detlev Ganten; S Takahashi; Klaus Lindpaintner; J Mullins
Genetic basis of hypertension. The renin-angiotensin paradigm.
Hypertension 1991;18(5 Suppl):III109-14.
1991: M Feldmer; M Kaling; S Takahashi; J J Mullins; Detlev Ganten
Glucocorticoid- and estrogen-responsive elements in the 5'-flanking region of the rat angiotensinogen gene.
Journal of hypertension 1991;9(11):1005-12.
1991: Detlev Ganten; Klaus Lindpaintner; U Ganten; Jörg Peters; F Zimmermann; Michael Bader; J Mullins
Transgenic rats: new animal models in hypertension research. Invited lecture.
Hypertension 1991;17(6 Pt 2):843-55.
1991: Klaus Lindpaintner; Detlev Ganten
The cardiac renin-angiotensin system. An appraisal of present experimental and clinical evidence.
Circulation research 1991;68(4):905-21.
1991: Detlev Ganten; Martin Paul; R E Lang
The role of neuropeptides in cardiovascular regulation.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1991;5(1):119-30.
1991: J Bachmann; M Feldmer; U Ganten; G Stock; Detlev Ganten
Sexual dimorphism of blood pressure: possible role of the renin-angiotensin system.
The Journal of steroid biochemistry and molecular biology 1991;40(4-6):511-5.
1991: M Kuczera; K F Hilgers; C Lisson; Detlev Ganten; Ulrich Hilgenfeldt; Eberhard Ritz; Johannes F E Mann
Local angiotensin formation in hindlimbs of uremic hypertensive and renovascular hypertensive rats.
Journal of hypertension 1991;9(1):41-8.
1990: J T McCabe; E Lehmann; N Chastrette; J Hänze; R E Lang; Detlev Ganten; Donald Pfaff
Detection of vasopressin mRNA in the neurointermediate lobe of the rat pituitary.
Brain research. Molecular brain research 1990;8(4):325-9.
1990: Klaus Lindpaintner; M W Jin; N Niedermaier; M J Wilhelm; Detlev Ganten
Cardiac angiotensinogen and its local activation in the isolated perfused beating heart.
Circulation research 1990;67(3):564-73.
1990: Klaus Lindpaintner; S Takahashi; Detlev Ganten
Structural alterations of the renin gene in stroke-prone spontaneously hypertensive rats: examination of genotype-phenotype correlations.
Journal of hypertension 1990;8(8):763-73.
1990: Ingo Morano; J Gerstner; J Caspar Rüegg; U Ganten; Detlev Ganten; H P Vosberg
Regulation of myosin heavy chain expression in the hearts of hypertensive rats by testosterone.
Circulation research 1990;66(6):1585-90.
1990: C Keuneke; R Yacullo; R Metzger; T Hellmann; Jörg Peters; Detlev Ganten
The role of tissue renin-angiotensin systems in hypertension and effects of chronic converting-enzyme inhibition.
European heart journal 1990;11 Suppl D():11-6.
1990: J J Mullins; Jörg Peters; Detlev Ganten
Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene.
Nature 1990;344(6266):541-4.
1990: Detlev Ganten
Peptidergic control of cardiovascular function: the angiotensin paradigm.
European heart journal 1990;11 Suppl B():72-8.
1990: E Lehmann; J Hänze; M Pauschinger; Detlev Ganten; R E Lang
Vasopressin mRNA in the neurolobe of the rat pituitary.
Neuroscience letters 1990;111(1-2):170-5.
1990: C Klett; W Hellmann; E Hackenthal; Detlev Ganten
[Pathophysiology of the renin-angiotensin system].
Wiener medizinische Wochenschrift (1946) 1990;140(1-2):2-12.
1990: D Wagner; R Metzger; Martin Paul; G Ludwig; F Suzuki; S Takahashi; K Murakami; Detlev Ganten
Androgen dependence and tissue specificity of renin messenger RNA expression in mice.
Journal of hypertension 1990;8(1):45-52.
1989: K F Hilgers; M Kuczera; M J Wilhelm; A Wiecek; Eberhard Ritz; Detlev Ganten; Johannes F E Mann
Angiotensin formation in the isolated rat hindlimb.
Journal of hypertension 1989;7(10):789-98.
1989: F C Luft; Christopher Wilcox; Thomas Unger; R Kühn; G Demmert; P Rohmeiss; Detlev Ganten; R B Sterzel
Angiotensin-induced hypertension in the rat. Sympathetic nerve activity and prostaglandins.
Hypertension 1989;14(4):396-403.
1989: U Ganten; G Schröder; M Witt; F Zimmermann; Detlev Ganten; G Stock
Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment.
Journal of hypertension 1989;7(9):721-6.
1989: R Rettig; Harald M Stauss; C Folberth; Detlev Ganten; B Waldherr; Thomas Unger
Hypertension transmitted by kidneys from stroke-prone spontaneously hypertensive rats.
The American journal of physiology 1989;257(2 Pt 2):F197-203.
1989: Detlev Ganten; J Mullins; Klaus Lindpaintner
The tissue renin-angiotensin system: a target for angiotensin-converting enzyme inhibitors.
Journal of human hypertension 1989;3 Suppl 1():63-70.
1989: W Linz; B Schölkens; K Lindpaintner; Detlev Ganten
Cardiac renin-angiotensin system.
American journal of hypertension 1989;2(4):307-10.
1989: Thomas Unger; Peter Gohlke; Detlev Ganten; R E Lang
Converting enzyme inhibitors and their effects on the renin-angiotensin system of the blood vessel wall.
Journal of cardiovascular pharmacology 1989;13 Suppl 3():S8-16.
1988: C Klett; W Hellmann; F Müller; F Suzuki; S Nakanishi; H Ohkubo; Detlev Ganten; E Hackenthal
Angiotensin II controls angiotensinogen secretion at a pretranslational level.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1988;6(4):S442-5.
1988: M Lengsfeld; Ingo Morano; U Ganten; Detlev Ganten; J Caspar Rüegg
Gonadectomy and hormonal replacement changes systolic blood pressure and ventricular myosin isoenzyme pattern of spontaneously hypertensive rats.
Circulation research 1988;63(6):1090-4.
1988: Johannes F E Mann; S Eisele; R Rettig; Thomas Unger; A K Johnson; Detlev Ganten; Eberhard Ritz
Renin-dependent water intake in hypovolemia.
Pflügers Archiv : European journal of physiology 1988;412(6):574-8.
1988: J T McCabe; K Almasan; E Lehmann; J Hänze; R E Lang; Donald Pfaff; Detlev Ganten
In situ hybridization demonstrates vasopressin gene transcription in hypothalamic neurons of crossbred hypertensive x diabetes insipidus rats.
Neuroscience 1988;27(1):159-67.
1988: Thomas Unger; S Carolus; G Demmert; Detlev Ganten; R E Lang; Christiane Maser-Gluth; H Steinberg; R Veelken
Substance P induces a cardiovascular defense reaction in the rat: pharmacological characterization.
Circulation research 1988;63(4):812-20.
1988: W Hellmann; F Suzuki; H Ohkubo; S Nakanishi; G Ludwig; Detlev Ganten
Angiotensinogen gene expression in extrahepatic rat tissues: application of a solution hybridization assay.
Naunyn-Schmiedeberg's archives of pharmacology 1988;338(3):327-31.
1988: Klaus Lindpaintner; M Jin; M J Wilhelm; F Suzuki; Wolfgang Linz; B A Schoelkens; Detlev Ganten
Intracardiac generation of angiotensin and its physiologic role.
Circulation 1988;77(6 Pt 2):I18-23.
1988: K Hermann; Detlev Ganten; Thomas Unger; C Bayer; R E Lang
Measurement and characterization of angiotensin peptides in plasma.
Clinical chemistry 1988;34(6):1046-51.
1988: Thomas Unger; E Badoer; Detlev Ganten; R E Lang; R Rettig
Brain angiotensin: pathways and pharmacology.
Circulation 1988;77(6 Pt 2):I40-54.
1988: M Jin; M J Wilhelm; R E Lang; Thomas Unger; Klaus Lindpaintner; Detlev Ganten
Endogenous tissue renin-angiotensin systems. From molecular biology to therapy.
The American journal of medicine 1988;84(3A):28-36.
1988: Martin Paul; D Wagner; R Metzger; Detlev Ganten; R E Lang; F Suzuki; K Murakami; J H Burbach; G Ludwig
Quantification of renin mRNA in various mouse tissues by a novel solution hybridization assay.
Journal of hypertension 1988;6(3):247-52.
1988: F Suzuki; G Ludwig; W Hellmann; Martin Paul; Klaus Lindpaintner; K Murakami; Detlev Ganten
Renin gene expression in rat tissues: a new quantitative assay method for rat renin mRNA using synthetic cRNA.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10(2):345-59.
1988: J T McCabe; K Almasan; E Lehmann; J Hänze; R E Lang; Donald Pfaff; Detlev Ganten
Vasopressin gene expression in hypertensive, normotensive, and diabetes insipidus rats.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10 Suppl 1():131-42.
1988: C Klett; W Hellmann; F Suzuki; S Nakanishi; H Ohkubo; Detlev Ganten; E Hackenthal
Induction of angiotensinogen mRNA in hepatocytes by angiotensin II and glucocorticoids.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10(6):1009-22.
1988: F Suzuki; Klaus Lindpaintner; C Keuneke; W Hellmann; S Takahasi; Y Nakamura; H Ohkubo; S Nakanishi; K Murakami; Detlev Ganten
Tissue-specific regulation of gene expression for renin and angiotensinogen.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10(6):1317-9.
1988: R Metzger; D Wagner; S Takahashi; F Suzuki; Klaus Lindpaintner; Detlev Ganten
Tissue renin-angiotensin systems aspects of molecular biology and pharmacology.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10(6):1227-38.
1988: G Ludwig; J Hänze; E Lehmann; R E Lang; J H Burbach; Detlev Ganten
Measurement of mRNA by solution hybridization with 32P-labelled single stranded cRNA probe ("SP6 test"). Comparison with a 32P-labelled single stranded cDNA as hybridization probe ("S1 test") for measurement of AVP mRNA.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10(3):467-83.
1987: Klaus Lindpaintner; M J Wilhelm; M Jin; Thomas Unger; R E Lang; B A Schoelkens; Detlev Ganten
Tissue renin-angiotensin systems: focus on the heart.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1987;5(2):S33-8.
1986: Thomas Unger; P Rohmeiss; G Demmert; Detlev Ganten; R E Lang; F C Luft
Differential modulation of the baroreceptor reflex by brain and plasma vasopressin.
Hypertension 1986;8(6 Pt 2):II157-62.
1986: Thomas Unger; P Rohmeiss; G Demmert; F C Luft; Detlev Ganten; R E Lang
Differential actions of neuronal and hormonal vasopressin on blood pressure and baroreceptor reflex sensitivity in rats.
Journal of cardiovascular pharmacology 1986;8 Suppl 7():S81-6.
1985: A C Shisheva; M P Printz; K Herman; Detlev Ganten
Kinin-forming activity in rat brain.
Neurochemistry international 1985;7(4):621-9.
1984: K Hermann; R E Lang; Thomas Unger; C Bayer; Detlev Ganten
Combined high-performance liquid chromatography-radioimmunoassay for the characterization and quantitative measurement of neuropeptides.
Journal of chromatography 1984;312():273-84.
1983: Detlev Ganten; K Hermann; C Bayer; Thomas Unger; R E Lang
Angiotensin synthesis in the brain and increased turnover in hypertensive rats.
Science (New York, N.Y.) 1983;221(4613):869-71.
1976: W E Hoffman; P Schelling; M I Phillips; Detlev Ganten
Evidence for local angiotensin formation in brain of nephrectomized rats.
Neuroscience letters 1976;3(5-6):299-303.
1976: Kjell Fuxe; Detlev Ganten; Tomas Hökfelt; P Bolme
Immunohistochemical evidence for the existence of angiotensin II-containing nerve terminals in the brain and spinal cord in the rat.
Neuroscience letters 1976;2(4):229-34.