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Ira Gantz

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Chemicals & Drugs

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Mary F Morrison; Paulette Ceesay; Ira Gantz; Keith D Kaufman; Christopher R Lines
Randomized, controlled, double-blind trial of taranabant for smoking cessation.
Ngozi Erondu; Cheryl L Addy; Kaifeng Lu; Madhuja Mallick; Bret Musser; Ira Gantz; Joseph Proietto; Arne Astrup; Søren Toubro; Aila M Rissannen; Serena Tonstad; William G Haynes; Keith M Gottesdiener; Keith D Kaufman; John M Amatruda; Steven B Heymsfield
NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine.
Ira Gantz; Ngozi Erondu; Madhuja Mallick; Bret Musser; Rajesh Krishna; Wesley Tanaka; Karen Snyder; Cathy Stevens; Mark A Stroh; Haiyuan Zhu; John A Wagner; Douglas J MacNeil; Steven B Heymsfield; John M Amatruda
Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults.

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2010: Mary F Morrison; Paulette Ceesay; Ira Gantz; Keith D Kaufman; Christopher R Lines
Randomized, controlled, double-blind trial of taranabant for smoking cessation.
Psychopharmacology 2010;209(3):245-53.
2007: Ngozi Erondu; Cheryl L Addy; Kaifeng Lu; Madhuja Mallick; Bret Musser; Ira Gantz; Joseph Proietto; Arne Astrup; Søren Toubro; Aila M Rissannen; Serena Tonstad; William G Haynes; Keith M Gottesdiener; Keith D Kaufman; John M Amatruda; Steven B Heymsfield
NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine.
Obesity (Silver Spring, Md.) 2007;15(8):2027-42.
2007: Ira Gantz; Ngozi Erondu; Madhuja Mallick; Bret Musser; Rajesh Krishna; Wesley Tanaka; Karen Snyder; Cathy Stevens; Mark A Stroh; Haiyuan Zhu; John A Wagner; Douglas J MacNeil; Steven B Heymsfield; John M Amatruda
Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults.
The Journal of clinical endocrinology and metabolism 2007;92(5):1754-7.
2007: Ngozi Erondu; Thomas Wadden; Ira Gantz; Bret Musser; allison nguyen; Harold Bays; George Bray; Patrick M O'Neil; Arnaud Basdevant; Keith D Kaufman; Steven B Heymsfield; John M Amatruda
Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss.
Obesity (Silver Spring, Md.) 2007;15(4):895-905.
2006: Ngozi Erondu; Ira Gantz; Bret Musser; Shailaja Suryawanshi; Madhuja Mallick; Carol Addy; Josee Cote; George Bray; Ken Fujioka; Harold Bays; Priscilla Hollander; Sandra Sanabria; Waisi Eng; Bengt Långström; Richard Hargreaves; H Donald Burns; Akio Kanatani; Takehiro Fukami; Douglas J MacNeil; Keith M Gottesdiener; John M Amatruda; Keith D Kaufman; Steven B Heymsfield
Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.
Cell metabolism 2006;4(4):275-82.
2006: Steven B Heymsfield; Tung M Fong; Ira Gantz; Ngozi Erondu
Fat and energy partitioning: longitudinal observations in leptin-treated adults homozygous for a Lep mutation.
Obesity (Silver Spring, Md.) 2006;14(2):258-65.
2005: Pilgrim J Jackson; Bin Yu; Benjamin Hunrichs; Darren Thompson; Biaoxin Chai; Ira Gantz; Glenn L Millhauser
Chimeras of the agouti-related protein: insights into agonist and antagonist selectivity of melanocortin receptors.
Peptides 2005;26(10):1978-87.
2005: Irina D Pogozheva; Biaoxin Chai; Andrei L Lomize; Tung M Fong; David Weinberg; Ravi P Nargund; Michael W Mulholland; Ira Gantz; Henry I Mosberg
Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists.
Biochemistry 2005;44(34):11329-41.
2005: Ji-yao Li; Rork Kuick; Robert C Thompson; David E Misek; Yu-Mei Lai; Y-Q Liu; Biaoxin Chai; Samir M Hanash; Ira Gantz
Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits.
Journal of neuroendocrinology 2005;17(6):394-404.
2005: Biaoxin Chai; Irina D Pogozheva; Yu-Mei Lai; Ji-yao Li; Richard Neubig; Henry I Mosberg; Ira Gantz
Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors.
Biochemistry 2005;44(9):3418-31.
2005: Joseph McNulty; Pilgrim J Jackson; Darren Thompson; Biaoxin Chai; Ira Gantz; Gregory S Barsh; Philip E Dawson; Glenn L Millhauser
Structures of the agouti signaling protein.
Journal of molecular biology 2005;346(4):1059-70.
2004: Weizhen Zhang; Lili Zhao; Theodore R Lin; Biaoxin Chai; Yongyi Fan; Ira Gantz; Michael W Mulholland
Inhibition of adipogenesis by ghrelin.
Molecular biology of the cell 2004;15(5):2484-91.
2003: Glenn L Millhauser; Joseph McNulty; Pilgrim J Jackson; Darren Thompson; Gregory S Barsh; Ira Gantz
Loops and links: structural insights into the remarkable function of the agouti-related protein.
Annals of the New York Academy of Sciences 2003;994():27-35.
2003: Darren Thompson; Biaoxin Chai; Hilary L E Rood; Michael A Siani; Nick R Douglas; Ira Gantz; Glenn L Millhauser
Peptoid mimics of agouti related protein.
Bioorganic & medicinal chemistry letters 2003;13(8):1409-13.
2003: Biaoxin Chai; Richard Neubig; Glenn L Millhauser; Darren Thompson; Pilgrim J Jackson; Gregory S Barsh; Chris J Dickinson; Ji-yao Li; Yu-Mei Lai; Ira Gantz
Inverse agonist activity of agouti and agouti-related protein.
Peptides 2003;24(4):603-9.
2003: Ira Gantz; Tung M Fong
The melanocortin system.
American journal of physiology. Endocrinology and metabolism 2003;284(3):E468-74.
2002: Pilgrim J Jackson; Joseph McNulty; Ying-Kui Yang; Darren Thompson; Biaoxin Chai; Ira Gantz; Gregory S Barsh; Glenn L Millhauser
Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity.
Biochemistry 2002;41(24):7565-72.
2002: Ji-yao Li; Pascal A Lescure; David E Misek; Yu-Mei Lai; Biaoxin Chai; Rork Kuick; Robert C Thompson; Rebecca M Demo; David M Kurnit; George Michailidis; Samir M Hanash; Ira Gantz
Food deprivation-induced expression of minoxidil sulfotransferase in the hypothalamus uncovered by microarray analysis.
The Journal of biological chemistry 2002;277(11):9069-76.
2001: Ying-Kui Yang; Chris J Dickinson; Yu-Mei Lai; Ji-yao Li; Ira Gantz
Functional properties of an agouti signaling protein variant and characteristics of its cognate radioligand.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(6):R1877-86.
2001: S Y Qu; Ying-Kui Yang; Ji-yao Li; Qinghua Zeng; Ira Gantz
Agouti-related protein is a mediator of diabetic hyperphagia.
Regulatory peptides 2001;98(1-2):69-75.
2000: Ying-Kui Yang; Tung M Fong; Chris J Dickinson; C Mao; Ji-yao Li; Michael R Tota; Ralph T Mosley; Lex H T Van Der Ploeg; Ira Gantz
Molecular determinants of ligand binding to the human melanocortin-4 receptor.
Biochemistry 2000;39(48):14900-11.
2000: Gregory S Barsh; Teresa M Gunn; L He; B Wilson; Xin Yun Lu; Ira Gantz; Stanley J Watson Jr
Neuroendocrine regulation by the Agouti/Agrp-melanocortin system.
Endocrine research 2000;26(4):571.
2000: LD Wang; Ira Gantz; K Butler; MF Hoeltzel; John Del Valle
Histamine H2 receptor mediated dual signaling: mapping of structural requirements using beta2 adrenergic chimeric receptors.
Biochemical and biophysical research communications 2000;276(2):539-45.
2000: Ji-yao Li; S Finniss; Ying-Kui Yang; Qinghua Zeng; S Y Qu; Gregory S Barsh; Chris J Dickinson; Ira Gantz
Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum.
Endocrinology 2000;141(6):1942-50.
1999: D Bagnol; Xin Yun Lu; Christopher B Kaelin; Heidi E W Day; MM Ollmann; Ira Gantz; Huda Akil; Gregory S Barsh; Stanley J Watson Jr
Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(18):RC26.
1999: KA Bolin; D J Anderson; J A Trulson; Darren Thompson; Jill Wilken; Stephen B H Kent; Ira Gantz; Glenn L Millhauser
NMR structure of a minimized human agouti related protein prepared by total chemical synthesis.
FEBS letters 1999;451(2):125-31.
1999: Ying-Kui Yang; Chris J Dickinson; Qinghua Zeng; Ji-yao Li; Darren Thompson; Ira Gantz
Contribution of melanocortin receptor exoloops to Agouti-related protein binding.
The Journal of biological chemistry 1999;274(20):14100-6.
1999: BD Wilson; D Bagnol; Christopher B Kaelin; MM Ollmann; Ira Gantz; Stanley J Watson Jr; Gregory S Barsh
Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.
Endocrinology 1999;140(5):2387-97.
1999: Ying-Kui Yang; Darren Thompson; Chris J Dickinson; Jill Wilken; Gregory S Barsh; S B Kent; Ira Gantz
Characterization of Agouti-related protein binding to melanocortin receptors.
Molecular endocrinology (Baltimore, Md.) 1999;13(1):148-55.
1998: LD Wang; MF Hoeltzel; Ira Gantz; R Hunter; John Del Valle
Characterization of the histamine H2 receptor structural components involved in dual signaling.
The Journal of pharmacology and experimental therapeutics 1998;285(2):573-8.
1997: John Del Valle; Ira Gantz
Novel insights into histamine H2 receptor biology.
The American journal of physiology 1997;273(5 Pt 1):G987-96.
1997: MM Ollmann; BD Wilson; Ying-Kui Yang; Julie A Kerns; Y Chen; Ira Gantz; Gregory S Barsh
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.
Science (New York, N.Y.) 1997;278(5335):135-8.
1997: Y k Yang; Chris J Dickinson; Carrie Haskell-Luevano; Ira Gantz
Molecular basis for the interaction of [Nle4,D-Phe7]melanocyte stimulating hormone with the human melanocortin-1 receptor.
The Journal of biological chemistry 1997;272(37):23000-10.
1997: Carrie Haskell-Luevano; S Hendrata; C North; TK Sawyer; Mac E Hadley; Victor J Hruby; Chris J Dickinson; Ira Gantz
Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.
Journal of medicinal chemistry 1997;40(14):2133-9.
1997: Ira Gantz; A Muraoka; Ying-Kui Yang; Linda C Samuelson; EM Zimmerman; H Cook; T Yamada
Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis.
Genomics 1997;42(3):462-6.
1997: Carrie Haskell-Luevano; G Nikiforovich; S D Sharma; Ying-Kui Yang; Chris J Dickinson; Victor J Hruby; Ira Gantz
Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
Journal of medicinal chemistry 1997;40(11):1738-48.
1997: Ying-Kui Yang; MM Ollmann; BD Wilson; Chris J Dickinson; T Yamada; Gregory S Barsh; Ira Gantz
Effects of recombinant agouti-signaling protein on melanocortin action.
Molecular endocrinology (Baltimore, Md.) 1997;11(3):274-80.
1996: Chris J Dickinson; John Del Valle; Andrea Todisco; Ira Gantz; L Tong; S Finniss; Tadataka Yamada
Canine prosomatostatin: isolation of a cDNA, regulation of gene expression, and characterization of post-translational processing intermediates.
Regulatory peptides 1996;67(3):145-52.
1996: Carrie Haskell-Luevano; T K Sawyer; S Trumpp-Kallmeyer; J A Bikker; Christine Humblet; Ira Gantz; Victor J Hruby
Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists.
Drug design and discovery 1996;14(3):197-211.
1996: Linda C Samuelson; L J Swanberg; Ira Gantz
Mapping of the novel G protein-coupled receptor Gpr18 to distal mouse chromosome 14.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(12):920-1.
1996: L Wang; Ira Gantz; John Del Valle
Histamine H2 receptor activates adenylate cyclase and PLC via separate GTP-dependent pathways.
The American journal of physiology 1996;271(4 Pt 1):G613-20.
1996: Carrie Haskell-Luevano; H Miwa; Chris J Dickinson; Mac E Hadley; Victor J Hruby; Tadataka Yamada; Ira Gantz
Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.
Journal of medicinal chemistry 1996;39(2):432-5.
1996: Ira Gantz; Y Konda; Ying-Kui Yang; Diane E Miller; HA Dierick; Tadataka Yamada
Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors.
Cytogenetics and cell genetics 1996;74(4):286-90.
1995: Carrie Haskell-Luevano; L W Boteju; H Miwa; Chris J Dickinson; Ira Gantz; Tadataka Yamada; Mac E Hadley; Victor J Hruby
Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities.
Journal of medicinal chemistry 1995;38(23):4720-9.
1995: H Miwa; Ira Gantz; Y Konda; Y Shimoto; Tadataka Yamada
Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors.
The Journal of pharmacology and experimental therapeutics 1995;273(1):367-72.
1995: John Del Valle; Ira Gantz; L Wang; Y J Guo; G Munzert; T Tashiro; Y Konda; Tadataka Yamada
Construction of a novel bifunctional biogenic amine receptor by two point mutations of the H2-histamine receptor.
Molecular medicine (Cambridge, Mass.) 1995;1(3):280-6.
1994: Carrie Haskell-Luevano; H Miwa; Chris J Dickinson; Victor J Hruby; Tadataka Yamada; Ira Gantz
Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R.
Biochemical and biophysical research communications 1994;204(3):1137-42.
1994: Ira Gantz; Y Shimoto; Y Konda; H Miwa; Chris J Dickinson; Tadataka Yamada
Molecular cloning, expression, and characterization of a fifth melanocortin receptor.
Biochemical and biophysical research communications 1994;200(3):1214-20.
1994: Y Konda; Ira Gantz; John Del Valle; Y Shimoto; H Miwa; Tadataka Yamada
Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.
The Journal of biological chemistry 1994;269(18):13162-6.
1994: Ira Gantz; Tadataka Yamada; T Tashiro; Y Konda; Y Shimoto; H Miwa; Jeffrey M. Trent
Mapping of the gene encoding the melanocortin-1 (alpha-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24.3 by Fluorescence in situ hybridization.
Genomics 1994;19(2):394-5.
1993: I Song; M P Mortell; Ira Gantz; D R Brown; Tadataka Yamada
Molecular cloning and structural analysis of canine gastric H+,K(+)-ATPase.
Biochemical and biophysical research communications 1993;196(3):1240-7.
1993: I Song; D R Brown; R N Wiltshire; Ira Gantz; Jeffrey M. Trent; Tadataka Yamada
The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9085-9.
1993: Ira Gantz; T Tashiro; C Barcroft; Y Konda; Y Shimoto; H Miwa; Thomas W Glover; G Munzert; Tadataka Yamada
Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.
Genomics 1993;18(1):166-7.
1993: Ira Gantz; H Miwa; Y Konda; Y Shimoto; T Tashiro; Stanley J Watson Jr; John Del Valle; Tadataka Yamada
Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.
The Journal of biological chemistry 1993;268(20):15174-9.
1993: Ira Gantz; Y Konda; T Tashiro; Y Shimoto; H Miwa; G Munzert; Stanley J Watson Jr; John Del Valle; Tadataka Yamada
Molecular cloning of a novel melanocortin receptor.
The Journal of biological chemistry 1993;268(11):8246-50.
1992: John Del Valle; L Wang; Ira Gantz; Tadataka Yamada
Characterization of H2 histamine receptor: linkage to both adenylate cyclase and [Ca2+]i signaling systems.
The American journal of physiology 1992;263(6 Pt 1):G967-72.
1992: Ira Gantz; John Del Valle; LD Wang; T Tashiro; G Munzert; Y J Guo; Y Konda; Tadataka Yamada
Molecular basis for the interaction of histamine with the histamine H2 receptor.
The Journal of biological chemistry 1992;267(29):20840-3.
1991: Ira Gantz; G Munzert; T Tashiro; M Schäffer; L Wang; John Del Valle; Tadataka Yamada
Molecular cloning of the human histamine H2 receptor.
Biochemical and biophysical research communications 1991;178(3):1386-92.
1991: Ira Gantz; M Schäffer; John Del Valle; Craig D Logsdon; V Campbell; Michael D Uhler; Tadataka Yamada
Molecular cloning of a gene encoding the histamine H2 receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5937.
1991: Ira Gantz; M Schäffer; John Del Valle; Craig D Logsdon; V Campbell; Michael D Uhler; Tadataka Yamada
Molecular cloning of a gene encoding the histamine H2 receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):429-33.
1990: Ira Gantz; T Takeuchi; Tadataka Yamada
Cloning of canine gastrin cDNA's encoding variant amino acid sequences.
Digestion 1990;46 Suppl 2():99-104.
1989: Ira Gantz; S F Nothwehr; M Lucey; J C Sacchettini; John Del Valle; L J Banaszak; M Naud; J I Gordon; Tadataka Yamada
Gastrotropin: not an enterooxyntin but a member of a family of cytoplasmic hydrophobic ligand binding proteins.
The Journal of biological chemistry 1989;264(34):20248-54.