Ira Gantz

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Erondu Ngozi; Addy Carol; Lu Kaifeng; Mallick Madhuja; Musser Bret; Gantz Ira; Proietto Joseph; Astrup Arne; Toubro Søren; Rissannen Aila M; Tonstad Serena; Haynes William G; Gottesdiener Keith M; Kaufman Keith D; Amatruda John M; Heymsfield Steven B
NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine.
Gantz Ira; Erondu Ngozi; Mallick Madhuja; Musser Bret; Krishna Rajesh; Tanaka Wesley K; Snyder Karen; Stevens Cathy; Stroh Mark A; Zhu Haiyuan; Wagner John A; Macneil Douglas J; Heymsfield Steven B; Amatruda John M
Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults.
Erondu Ngozi; Wadden Thomas; Gantz Ira; Musser Bret; Nguyen Allison Martin; Bays Harold; Bray George; O'Neil Patrick M; Basdevant Arnaud; Kaufman Keith D; Heymsfield Steven B; Amatruda John M
Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss.

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All Publications

2007: Erondu Ngozi; Addy Carol; Lu Kaifeng; Mallick Madhuja; Musser Bret; Gantz Ira; Proietto Joseph; Astrup Arne; Toubro Søren; Rissannen Aila M; Tonstad Serena; Haynes William G; Gottesdiener Keith M; Kaufman Keith D; Amatruda John M; Heymsfield Steven B
NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine.
Obesity (Silver Spring, Md.) 2007;15(8):2027-42.
2007: Gantz Ira; Erondu Ngozi; Mallick Madhuja; Musser Bret; Krishna Rajesh; Tanaka Wesley K; Snyder Karen; Stevens Cathy; Stroh Mark A; Zhu Haiyuan; Wagner John A; Macneil Douglas J; Heymsfield Steven B; Amatruda John M
Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults.
The Journal of clinical endocrinology and metabolism 2007;92(5):1754-7.
2007: Erondu Ngozi; Wadden Thomas; Gantz Ira; Musser Bret; Nguyen Allison Martin; Bays Harold; Bray George; O'Neil Patrick M; Basdevant Arnaud; Kaufman Keith D; Heymsfield Steven B; Amatruda John M
Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss.
Obesity (Silver Spring, Md.) 2007;15(4):895-905.
2006: Erondu Ngozi; Gantz Ira; Musser Bret; Suryawanshi Shailaja; Mallick Madhuja; Addy Carol; Cote Josee; Bray George; Fujioka Ken; Bays Harold; Hollander Priscilla; Sanabria-Bohórquez Sandra M; Eng WaiSi; Långström Bengt; Hargreaves Richard J; Burns H Donald; Kanatani Akio; Fukami Takehiro; MacNeil Douglas J; Gottesdiener Keith M; Amatruda John M; Kaufman Keith D; Heymsfield Steven B
Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.
Cell metabolism 2006;4(4):275-82.
2006: Heymsfield Steven B; Fong Tung M; Gantz Ira; Erondu Ngozi
Fat and energy partitioning: longitudinal observations in leptin-treated adults homozygous for a Lep mutation.
Obesity (Silver Spring, Md.) 2006;14(2):258-65.
2005: Jackson Pilgrim J; Yu Bin; Hunrichs Benjamin; Thompson Darren A; Chai Biaoxin; Gantz Ira; Millhauser Glenn L
Chimeras of the agouti-related protein: insights into agonist and antagonist selectivity of melanocortin receptors.
Peptides 2005;26(10):1978-87.
2005: Pogozheva Irina D; Chai Biao-Xin; Lomize Andrei L; Fong Tung M; Weinberg David H; Nargund Ravi P; Mulholland Michael W; Gantz Ira; Mosberg Henry I
Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists.
Biochemistry 2005;44(34):11329-41.
2005: Li J-Y; Kuick R; Thompson R C; Misek D E; Lai Y-M; Liu Y-Q; Chai B-X; Hanash S M; Gantz I
Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits.
Journal of neuroendocrinology 2005;17(6):394-404.
2005: Chai Biao-Xin; Pogozheva Irina D; Lai Yu-Mei; Li Ji-Yao; Neubig Richard R; Mosberg Henry I; Gantz Ira
Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors.
Biochemistry 2005;44(9):3418-31.
2005: McNulty Joseph C; Jackson Pilgrim J; Thompson Darren A; Chai Biaoxin; Gantz Ira; Barsh Gregory S; Dawson Philip E; Millhauser Glenn L
Structures of the agouti signaling protein.
Journal of molecular biology 2005;346(4):1059-70.
2004: Zhang Weizhen; Zhao Lili; Lin Theodore R; Chai Biaoxin; Fan Yongyi; Gantz Ira; Mulholland Michael W
Inhibition of adipogenesis by ghrelin.
Molecular biology of the cell 2004;15(5):2484-91.
2003: Millhauser Glenn L; McNulty Joe C; Jackson Pilgrim J; Thompson Darren A; Barsh Gregory S; Gantz Ira
Loops and links: structural insights into the remarkable function of the agouti-related protein.
Annals of the New York Academy of Sciences 2003;994():27-35.
2003: Chai Biao-Xin; Neubig Richard R; Millhauser Glenn L; Thompson Darren A; Jackson Pilgrim J; Barsh Gregory S; Dickinson Chris J; Li Ji-Yao; Lai Yu-Mei; Gantz Ira
Inverse agonist activity of agouti and agouti-related protein.
Peptides 2003;24(4):603-9.
2003: Thompson Darren A; Chai Biao-Xin; Rood Hilary L E; Siani Michael A; Douglas Nicholai R; Gantz Ira; Millhauser Glenn L
Peptoid mimics of agouti related protein.
Bioorganic & medicinal chemistry letters 2003;13(8):1409-13.
2003: Gantz Ira; Fong Tung M
The melanocortin system.
American journal of physiology. Endocrinology and metabolism 2003;284(3):E468-74.
2002: Jackson Pilgrim J; McNulty Joseph C; Yang Ying-Kui; Thompson Darren A; Chai Biaoxin; Gantz Ira; Barsh Gregory S; Millhauser Glenn L
Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity.
Biochemistry 2002;41(24):7565-72.
2002: Li Ji-Yao; Lescure Pascal A; Misek David E; Lai Yu-Mei; Chai Biao-Xin; Kuick Rork; Thompson Robert C; Demo Rebecca M; Kurnit David M; Michailidis George; Hanash Samir M; Gantz Ira
Food deprivation-induced expression of minoxidil sulfotransferase in the hypothalamus uncovered by microarray analysis.
The Journal of biological chemistry 2002;277(11):9069-76.
2001: Yang Y K; Dickinson C; Lai Y M; Li J Y; Gantz I
Functional properties of an agouti signaling protein variant and characteristics of its cognate radioligand.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(6):R1877-86.
2001: Qu S Y; Yang Y K; Li J Y; Zeng Q; Gantz I
Agouti-related protein is a mediator of diabetic hyperphagia.
Regulatory peptides 2001;98(1-2):69-75.
2000: Yang Y K; Fong T M; Dickinson C J; Mao C; Li J Y; Tota M R; Mosley R; Van Der Ploeg L H; Gantz I
Molecular determinants of ligand binding to the human melanocortin-4 receptor.
Biochemistry 2000;39(48):14900-11.
2000: Barsh G; Gunn T; He L; Wilson B; Lu X; Gantz I; Watson S
Neuroendocrine regulation by the Agouti/Agrp-melanocortin system.
Endocrine research 2000;26(4):571.
2000: Wang L D; Gantz I; Butler K; Hoeltzel M; Del Valle J
Histamine H2 receptor mediated dual signaling: mapping of structural requirements using beta2 adrenergic chimeric receptors.
Biochemical and biophysical research communications 2000;276(2):539-45.
2000: Li J Y; Finniss S; Yang Y K; Zeng Q; Qu S Y; Barsh G; Dickinson C; Gantz I
Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum.
Endocrinology 2000;141(6):1942-50.
1999: Bagnol D; Lu X Y; Kaelin C B; Day H E; Ollmann M; Gantz I; Akil H; Barsh G S; Watson S J
Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(18):RC26.
1999: Bolin K A; Anderson D J; Trulson J A; Thompson D A; Wilken J; Kent S B; Gantz I; Millhauser G L
NMR structure of a minimized human agouti related protein prepared by total chemical synthesis.
FEBS letters 1999;451(2):125-31.
1999: Yang Y K; Dickinson C J; Zeng Q; Li J Y; Thompson D A; Gantz I
Contribution of melanocortin receptor exoloops to Agouti-related protein binding.
The Journal of biological chemistry 1999;274(20):14100-6.
1999: Wilson B D; Bagnol D; Kaelin C B; Ollmann M M; Gantz I; Watson S J; Barsh G S
Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.
Endocrinology 1999;140(5):2387-97.
1999: Yang Y K; Thompson D A; Dickinson C J; Wilken J; Barsh G S; Kent S B; Gantz I
Characterization of Agouti-related protein binding to melanocortin receptors.
Molecular endocrinology (Baltimore, Md.) 1999;13(1):148-55.
1998: Wang L D; Hoeltzel M; Gantz I; Hunter R; Del Valle J
Characterization of the histamine H2 receptor structural components involved in dual signaling.
The Journal of pharmacology and experimental therapeutics 1998;285(2):573-8.
1997: Del Valle J; Gantz I
Novel insights into histamine H2 receptor biology.
The American journal of physiology 1997;273(5 Pt 1):G987-96.
1997: Ollmann M M; Wilson B D; Yang Y K; Kerns J A; Chen Y; Gantz I; Barsh G S
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.
Science (New York, N.Y.) 1997;278(5335):135-8.
1997: Yang Y k; Dickinson C; Haskell-Luevano C; Gantz I
Molecular basis for the interaction of [Nle4,D-Phe7]melanocyte stimulating hormone with the human melanocortin-1 receptor.
The Journal of biological chemistry 1997;272(37):23000-10.
1997: Haskell-Luevano C; Hendrata S; North C; Sawyer T K; Hadley M E; Hruby V J; Dickinson C; Gantz I
Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.
Journal of medicinal chemistry 1997;40(14):2133-9.
1997: Gantz I; Muraoka A; Yang Y K; Samuelson L C; Zimmerman E M; Cook H; Yamada T
Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis.
Genomics 1997;42(3):462-6.
1997: Haskell-Luevano C; Nikiforovich G; Sharma S D; Yang Y K; Dickinson C; Hruby V J; Gantz I
Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
Journal of medicinal chemistry 1997;40(11):1738-48.
1997: Yang Y K; Ollmann M M; Wilson B D; Dickinson C; Yamada T; Barsh G S; Gantz I
Effects of recombinant agouti-signaling protein on melanocortin action.
Molecular endocrinology (Baltimore, Md.) 1997;11(3):274-80.
1996: Haskell-Luevano C; Sawyer T K; Trumpp-Kallmeyer S; Bikker J A; Humblet C; Gantz I; Hruby V J
Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists.
Drug design and discovery 1996;14(3):197-211.
1996: Samuelson L C; Swanberg L J; Gantz I
Mapping of the novel G protein-coupled receptor Gpr18 to distal mouse chromosome 14.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(12):920-1.
1996: Dickinson C J; DelValle J; Todisco A; Gantz I; Tong L; Finniss S; Yamada T
Canine prosomatostatin: isolation of a cDNA, regulation of gene expression, and characterization of post-translational processing intermediates.
Regulatory peptides 1996;67(3):145-52.
1996: Wang L; Gantz I; DelValle J
Histamine H2 receptor activates adenylate cyclase and PLC via separate GTP-dependent pathways.
The American journal of physiology 1996;271(4 Pt 1):G613-20.
1996: Haskell-Luevano C; Miwa H; Dickinson C; Hadley M E; Hruby V J; Yamada T; Gantz I
Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.
Journal of medicinal chemistry 1996;39(2):432-5.
1996: Gantz I; Konda Y; Yang Y K; Miller D E; Dierick H A; Yamada T
Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors.
Cytogenetics and cell genetics 1996;74(4):286-90.
1995: Haskell-Luevano C; Boteju L W; Miwa H; Dickinson C; Gantz I; Yamada T; Hadley M E; Hruby V J
Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities.
Journal of medicinal chemistry 1995;38(23):4720-9.
1995: Miwa H; Gantz I; Konda Y; Shimoto Y; Yamada T
Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors.
The Journal of pharmacology and experimental therapeutics 1995;273(1):367-72.
1995: DelValle J; Gantz I; Wang L; Guo Y J; Munzert G; Tashiro T; Konda Y; Yamada T
Construction of a novel bifunctional biogenic amine receptor by two point mutations of the H2-histamine receptor.
Molecular medicine (Cambridge, Mass.) 1995;1(3):280-6.
1994: Haskell-Luevano C; Miwa H; Dickinson C; Hruby V J; Yamada T; Gantz I
Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R.
Biochemical and biophysical research communications 1994;204(3):1137-42.
1994: Gantz I; Shimoto Y; Konda Y; Miwa H; Dickinson C J; Yamada T
Molecular cloning, expression, and characterization of a fifth melanocortin receptor.
Biochemical and biophysical research communications 1994;200(3):1214-20.
1994: Konda Y; Gantz I; DelValle J; Shimoto Y; Miwa H; Yamada T
Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.
The Journal of biological chemistry 1994;269(18):13162-6.
1994: Gantz I; Yamada T; Tashiro T; Konda Y; Shimoto Y; Miwa H; Trent J M
Mapping of the gene encoding the melanocortin-1 (alpha-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24.3 by Fluorescence in situ hybridization.
Genomics 1994;19(2):394-5.
1993: Song I; Mortell M P; Gantz I; Brown D R; Yamada T
Molecular cloning and structural analysis of canine gastric H+,K(+)-ATPase.
Biochemical and biophysical research communications 1993;196(3):1240-7.
1993: Song I; Brown D R; Wiltshire R N; Gantz I; Trent J M; Yamada T
The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9085-9.
1993: Gantz I; Tashiro T; Barcroft C; Konda Y; Shimoto Y; Miwa H; Glover T; Munzert G; Yamada T
Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.
Genomics 1993;18(1):166-7.
1993: Gantz I; Miwa H; Konda Y; Shimoto Y; Tashiro T; Watson S J; DelValle J; Yamada T
Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.
The Journal of biological chemistry 1993;268(20):15174-9.
1993: Gantz I; Konda Y; Tashiro T; Shimoto Y; Miwa H; Munzert G; Watson S J; DelValle J; Yamada T
Molecular cloning of a novel melanocortin receptor.
The Journal of biological chemistry 1993;268(11):8246-50.
1992: Delvalle J; Wang L; Gantz I; Yamada T
Characterization of H2 histamine receptor: linkage to both adenylate cyclase and [Ca2+]i signaling systems.
The American journal of physiology 1992;263(6 Pt 1):G967-72.
1992: Gantz I; DelValle J; Wang L D; Tashiro T; Munzert G; Guo Y J; Konda Y; Yamada T
Molecular basis for the interaction of histamine with the histamine H2 receptor.
The Journal of biological chemistry 1992;267(29):20840-3.
1991: Gantz I; Munzert G; Tashiro T; Schäffer M; Wang L; DelValle J; Yamada T
Molecular cloning of the human histamine H2 receptor.
Biochemical and biophysical research communications 1991;178(3):1386-92.
1991: Gantz I; Schäffer M; DelValle J; Logsdon C; Campbell V; Uhler M; Yamada T
Molecular cloning of a gene encoding the histamine H2 receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5937.
1991: Gantz I; Schäffer M; DelValle J; Logsdon C; Campbell V; Uhler M; Yamada T
Molecular cloning of a gene encoding the histamine H2 receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):429-33.
1990: Gantz I; Takeuchi T; Yamada T
Cloning of canine gastrin cDNA's encoding variant amino acid sequences.
Digestion 1990;46 Suppl 2():99-104.
1989: Gantz I; Nothwehr S F; Lucey M; Sacchettini J C; DelValle J; Banaszak L J; Naud M; Gordon J I; Yamada T
Gastrotropin: not an enterooxyntin but a member of a family of cytoplasmic hydrophobic ligand binding proteins.
The Journal of biological chemistry 1989;264(34):20248-54.

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Ira Gantz

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