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Yang Gao

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Chemicals & Drugs

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Physiology

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Publications

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Alessio Giubellino; Yang Gao; Sunmin Lee; Min-Jung Lee; James R Vasselli; Sampath Medepalli; Jane Trepel; Terrence R Burke; Donald Bottaro
Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.
Jesus V Soriano; Ningfei Liu; Yang Gao; Zhu-Jun Yao; Toshio Ishibashi; Charles Underhill; Terrence R Burke; Donald Bottaro
Inhibition of angiogenesis by growth factor receptor bound protein 2-Src homology 2 domain bound antagonists.
Sang-Uk Kang; Yang Gao; Li Wu; Zhong-Yin Zhang; Terrence R Burke
Enantioselective synthesis of (S)-3-carboxy-4-((carboxy)difluoromethyl)phenylalanine in protected form and its incorporation into a PTP-1B-directed tripeptide.

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All Publications

2007: Alessio Giubellino; Yang Gao; Sunmin Lee; Min-Jung Lee; James R Vasselli; Sampath Medepalli; Jane Trepel; Terrence R Burke; Donald Bottaro
Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.
Cancer research 2007;67(13):6012-6.
2004: Jesus V Soriano; Ningfei Liu; Yang Gao; Zhu-Jun Yao; Toshio Ishibashi; Charles Underhill; Terrence R Burke; Donald Bottaro
Inhibition of angiogenesis by growth factor receptor bound protein 2-Src homology 2 domain bound antagonists.
Molecular cancer therapeutics 2004;3(10):1289-99.
2004: Sang-Uk Kang; Yang Gao; Li Wu; Zhong-Yin Zhang; Terrence R Burke
Enantioselective synthesis of (S)-3-carboxy-4-((carboxy)difluoromethyl)phenylalanine in protected form and its incorporation into a PTP-1B-directed tripeptide.
Chemistry & biodiversity 2004;1(4):626-33.
2003: Ding-Guo Liu; Yang Gao; Johannes H Voigt; Kyeong Lee; Marc C Nicklaus; Li Wu; Zhong-Yin Zhang; Terrence R Burke
Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.
Bioorganic & medicinal chemistry letters 2003;13(18):3005-7.
2003: Chang-Qing Wei; Yang Gao; Kyeong Lee; Ribo Guo; Bihua Li; Manchao Zhang; Dajun Yang; Terrence R Burke
Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.
Journal of medicinal chemistry 2003;46(2):244-54.
2002: Ding-Guo Liu; Yang Gao; Xiangzhu Wang; James A Kelley; Terrence R Burke
Enantioselective synthesis of N(alpha)-Fmoc protected (2S,3R)-3-phenylpipecolic acid. A constrained phenylalanine analogue suitably protected for solid-phase peptide synthesis.
The Journal of organic chemistry 2002;67(5):1448-52.
2001: Yang Gao; J Voigt; H Zhao; Godwin C G Pais; Xuechun Zhang; L Wu; Zhong-Yin Zhang; Terrence R Burke
Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif.
Journal of medicinal chemistry 2001;44(18):2869-78.
2001: Yang Gao; J Voigt; J X Wu; Dajun Yang; Terrence R Burke
Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor.
Bioorganic & medicinal chemistry letters 2001;11(14):1889-92.
2001: Terrence R Burke; Zhu-Jun Yao; Yang Gao; J X Wu; X Zhu; Juliet H Luo; R Guo; D Yang
N-terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding.
Bioorganic & medicinal chemistry 2001;9(6):1439-45.
2001: Yang Gao; Chang-Qing Wei; Terrence R Burke
Olefin metathesis in the design and synthesis of a globally constrained Grb2 SH2 domain inhibitor.
Organic letters 2001;3(11):1617-20.
2001: N Atabey; Yang Gao; Zhu-Jun Yao; Diane Breckenridge; Lilian Soon; Jesus V Soriano; Terrence R Burke; Donald Bottaro
Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions.
The Journal of biological chemistry 2001;276(17):14308-14.
2001: Terrence R Burke; Zhu-Jun Yao; Ding-Guo Liu; J Voigt; Yang Gao
Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors.
Biopolymers 2001;60(1):32-44.
2000: Terrence R Burke; Ding-Guo Liu; Yang Gao
Use of a Heck reaction for the synthesis of a new alpha-azido phosphotyrosyl mimetic suitably protected for peptide synthesis.
The Journal of organic chemistry 2000;65(19):6288-91.
2000: Yang Gao; L Wu; Juliet H Luo; R Guo; D Yang; ZY Zhang; Terrence R Burke
Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains.
Bioorganic & medicinal chemistry letters 2000;10(9):923-7.
2000: Yang Gao; J Luo; Zhu-Jun Yao; R Guo; H Zou; J Kelley; Johannes H Voigt; D Yang; Terrence R Burke
Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic.
Journal of medicinal chemistry 2000;43(5):911-20.
1999: Terrence R Burke; J Luo; Zhu-Jun Yao; Yang Gao; Hong Zhao; GW Milne; R Guo; Johannes H Voigt; CR King; D Yang
Monocarboxylic-based phosphotyrosyl mimetics in the design of GRB2 SH2 domain inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(3):347-52.