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Christiane Garbay

Research Profile

Chemicals & Drugs

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Manal Sarkis; Diem Ngan Tran; Bruno O Villoutreix; Christiane Garbay; Stéphanie Kolb; Maria A Miteva; Emmanuelle Braud
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.
Barbara Allain; Sara Bianco; Lucia Borriello; Sylvie Dufour; Christiane Garbay; Réda Hadj-Slimane; Rafika Jarray; Jérôme Larghero; Bertrand Leforban; Wang-Qing Liu; perayot Pamonsinlapatham; Françoise Raynaud; yves lepelletier
Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells.
Rafika Jarray; Jérôme Larghero; yves lepelletier; Ali Loukaci; Barbara Allain; Denis Biard; Lucia Borriello; Christiane Garbay; Réda Hadj-Slimane; Françoise Raynaud
Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis.

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All Publications

2012: Manal Sarkis; Diem Ngan Tran; Bruno O Villoutreix; Christiane Garbay; Stéphanie Kolb; Maria A Miteva; Emmanuelle Braud
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.
Bioorganic & medicinal chemistry letters 2012;22(24):7345-50.
2012: Barbara Allain; Sara Bianco; Lucia Borriello; Sylvie Dufour; Christiane Garbay; Réda Hadj-Slimane; Rafika Jarray; Jérôme Larghero; Bertrand Leforban; Wang-Qing Liu; perayot Pamonsinlapatham; Françoise Raynaud; yves lepelletier
Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells.
Cellular signalling 2012;24(1):214-23.
2011: Rafika Jarray; Jérôme Larghero; yves lepelletier; Ali Loukaci; Barbara Allain; Denis Biard; Lucia Borriello; Christiane Garbay; Réda Hadj-Slimane; Françoise Raynaud
Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis.
Biochimie 2011;93(10):1668-75.
2010: Raphaël Labruère; Benoît Gautier; Marlène Testud; Johanne Seguin; Christine Lenoir; Stéphanie Desbène-Finck; Philippe Helissey; Christiane Garbay; Guy G Chabot; Michel Vidal; Sylviane Giorgi-Renault
Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents.
ChemMedChem 2010;5(12):2016-25.
2010: Edith Browaeys-Poly; Christophe Blanquart; Dominique Perdereau; Anne-Frédérique Antoine; Diana Goenaga; Jean-Philippe Luzy; Huixiong Chen; Christiane Garbay; Tarik Issad; katia cailliau; Anne-Françoise Burnol
Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation.
FEBS letters 2010;584(21):4383-8.
2010: Réda Hadj-Slimane; perayot Pamonsinlapatham; Jean-Philippe Herbeuval; Christiane Garbay; yves lepelletier; Françoise Raynaud
RasV12 induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance.
Cellular signalling 2010;22(8):1214-21.
2010: Benoit Gautier; Victor Goncalves; Donatella Diana; Rossella Di Stasi; Florence Teillet; Christine Lenoir; Florent Huguenot; Christiane Garbay; Roberto Fattorusso; Luca Domenico D'Andrea; Michel Vidal; Nicolas Inguimbert
Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist.
Journal of medicinal chemistry 2010;53(11):4428-40.
2010: Benoit de Courcy; Jean-Philip Piquemal; Christiane Garbay; Nohad Gresh
Polarizable water molecules in ligand-macromolecule recognition. Impact on the relative affinities of competing pyrrolopyrimidine inhibitors for FAK kinase.
Journal of the American Chemical Society 2010;132(10):3312-20.
2010: Stéphanie Kolb; Mary-Lorène Goddard; Ali Loukaci; Odile Mondésert; Bernard Ducommun; Emmanuelle Braud; Christiane Garbay
5-Substituted [1]pyrindine derivatives with antiproliferative activity.
European journal of medicinal chemistry 2010;45(3):896-901.
2009: Romain Duval; Stéphanie Kolb; Emmanuelle Braud; David Genest; Christiane Garbay
Rapid discovery of triazolobenzylidene-thiazolopyrimidines (TBTP) as CDC25 phosphatase inhibitors by parallel click chemistry and in situ screening.
Journal of combinatorial chemistry 2009;11(6):947-50.
2009: Jennifer Dourlat; Wang-Qing Liu; Florence Sancier; Thomas Edmonds; perayot Pamonsinlapatham; Francisco Cruzalegui; Christiane Garbay
A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity.
Biochimie 2009;91(8):996-1002.
2009: Victor Goncalves; Benoit Gautier; Florent Huguenot; Pascale Leproux; Christiane Garbay; Michel Vidal; Nicolas Inguimbert
Total chemical synthesis of the D2 domain of human VEGF receptor 1.
Journal of peptide science : an official publication of the European Peptide Society 2009;15(6):417-22.
2009: Navin K Verma; Jennifer Dourlat; Anthony M Davies; Aideen Long; Wang-Qing Liu; Christiane Garbay; Dermot Kelleher; Yuri Volkov
STAT3-stathmin interactions control microtubule dynamics in migrating T-cells.
The Journal of biological chemistry 2009;284(18):12349-62.
2009: Stéphanie Kolb; Odile Mondésert; Mary-Lorène Goddard; Denis Jullien; Bruno Villoutreix; Bernard Ducommun; Christiane Garbay; Emmanuelle Braud
Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors.
ChemMedChem 2009;4(4):633-48.
2009: perayot Pamonsinlapatham; Réda Hadj-Slimane; yves lepelletier; Barbara Allain; Mirco Toccafondi; Christiane Garbay; Françoise Raynaud
p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling.
Biochimie 2009;91(3):320-8.
2008: perayot Pamonsinlapatham; Brunilde Gril; Sylvie Dufour; Réda Hadj-Slimane; Véronique Gigoux; Stéphanie Pethe; Sébastien L'Hoste; Jacques Camonis; Christiane Garbay; Françoise Raynaud; Michel Vidal
Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration.
Cellular signalling 2008;20(11):2119-26.
2008: Emmanuelle Braud; Mary-Lorène Goddard; Stéphanie Kolb; Marie-Priscille Brun; Odile Mondésert; Muriel Quaranta; Nohad Gresh; BERNARD DUCOMMUN; Christiane Garbay
Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.
Bioorganic & medicinal chemistry 2008;16(19):9040-9.
2008: Victor Goncalves; Benoit Gautier; Christiane Garbay; Michel Vidal; Nicolas Inguimbert
Structure-based design of a bicyclic peptide antagonist of the vascular endothelial growth factor receptors.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(6):767-72.
2007: Victor Goncalves; Benoit Gautier; Pascale Coric; Serge Bouaziz; Christine Lenoir; Christiane Garbay; Michel Vidal; Nicolas Inguimbert
Rational design, structure, and biological evaluation of cyclic peptides mimicking the vascular endothelial growth factor.
Journal of medicinal chemistry 2007;50(21):5135-46.
2007: Victor Goncalves; Benoit Gautier; Anne Regazzetti; Pascale Coric; Serge Bouaziz; Christiane Garbay; Michel Vidal; Nicolas Inguimbert
On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition.
Bioorganic & medicinal chemistry letters 2007;17(20):5590-4.
2007: Réda Hadj-Slimane; yves lepelletier; Nicolas Lopez; Christiane Garbay; Françoise Raynaud
Short interfering RNA (siRNA), a novel therapeutic tool acting on angiogenesis.
Biochimie 2007;89(10):1234-44.
2007: Jennifer Dourlat; Bruno Valentin; Wang-Qing Liu; Christiane Garbay
New syntheses of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(14):3943-6.
2007: Brunilde Gril; Michel Vidal; Franck Assayag; Marie-France Poupon; Wang-Qing Liu; Christiane Garbay
Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel.
International journal of cancer. Journal international du cancer 2007;121(2):407-15.
2007: Victor Goncalves; Benoit Gautier; Christiane Garbay; Michel Vidal; Nicolas Inguimbert
Development of a chemiluminescent screening assay for detection of vascular endothelial growth factor receptor 1 ligands.
Analytical biochemistry 2007;366(1):108-10.
2007: Jennifer Dourlat; Wang-Qing Liu; Nohad Gresh; Christiane Garbay
Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines.
Bioorganic & medicinal chemistry letters 2007;17(9):2527-30.
2006: Brunilde Gril; Wang-Qing Liu; Christine Lenoir; Christiane Garbay; Michel Vidal
Affinity chromatography for purification of the modular protein growth factor receptor-bound protein 2 and development of a screening test for growth factor receptor-bound protein 2 Src homology 3 domain inhibitor using peroxidase-linked ligand.
Analytical biochemistry 2006;351(1):93-9.
2005: katia cailliau; Dominique Perdereau; Arlette Lescuyer; Huixiong Chen; Christiane Garbay; Jean-Pierre Vilain; Anne-Françoise Burnol; Edith Browaeys-Poly
FGF receptor phosphotyrosine 766 is a target for Grb14 to inhibit MDA-MB-231 human breast cancer cell signaling.
Anticancer research 2005;25(6B):3877-82.
2005: Marie-Priscille Brun; Emmanuelle Braud; Delphine Angotti; Odile Mondésert; Muriel Quaranta; Matthieu Montes; Maria A Miteva; Nohad Gresh; BERNARD DUCOMMUN; Christiane Garbay
Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity.
Bioorganic & medicinal chemistry 2005;13(16):4871-9.
2004: Bruno Bellier; Dominique Crété; Marie-Emmanuelle Million; Françoise Beslot; André Bado; Christiane Garbay; Valérie Daugé
New CCK2 agonists confirming the heterogeneity of CCK2 receptors: characterisation of BBL454.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(5):404-13.
2004: Marie-Priscille Brun; Laurent Bischoff; Christiane Garbay
A very short route to enantiomerically pure coumarin-bearing fluorescent amino acids.
Angewandte Chemie (International ed. in English) 2004;43(26):3432-6.
2004: Michel Vidal; Wang-Qing Liu; Christine Lenoir; Julie Salzmann; Nohad Gresh; Christiane Garbay
Design of peptoid analogue dimers and measure of their affinity for Grb2 SH3 domains.
Biochemistry 2004;43(23):7336-44.
2004: Wang-Qing Liu; Michel Vidal; Catherine Olszowy; Emmanuelle Million; Christine Lenoir; Hélène Dhôtel; Christiane Garbay
Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs.
Journal of medicinal chemistry 2004;47(5):1223-33.
2004: Bruno Bellier; Christophe Dugave; Frédéric Etivant; Roger Genet; Véronique Gigoux; Christiane Garbay
Synthesis and biological characterisation of [3H]BBL454, a new CCK2 selective radiolabelled agonist displaying original pharmacological properties.
Bioorganic & medicinal chemistry letters 2004;14(2):369-72.
2004: Michel Vidal; Wang-Qing Liu; Brunilde Gril; Franck Assayag; Marie-France Poupon; Christiane Garbay
[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2].
Journal de la Société de biologie 2004;198(2):133-7.
2003: Bruno Bellier; Christiane Garbay
How a single inversion of configuration leads to a reversal of the binding mode: proposal of a novel arrangement of CCK2 ligands in their receptor, and contribution to the development of peptidomimetic or non-peptide CCK2 ligands.
European journal of medicinal chemistry 2003;38(7-8):671-86.
2002: Véronique Gigoux; Sébastien L'Hoste; Francoise Raynaud; Jacques Camonis; Christiane Garbay
Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins.
The Journal of biological chemistry 2002;277(26):23742-6.
2002: Pierre Nioche; Wang-Qing Liu; Isabelle Broutin; Franck Charbonnier; Marie-Thérèse Latreille; Michel Vidal; Bernard P Roques; Christiane Garbay; Arnaud Ducruix
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
Journal of molecular biology 2002;315(5):1167-77.
2001: M Vidal; Véronique Gigoux; Christiane Garbay
SH2 and SH3 domains as targets for anti-proliferative agents.
Critical reviews in oncology/hematology 2001;40(2):175-86.
2001: katia cailliau; Edith Browaeys-Poly; I Broutin-L'Hermite; Pierre Nioche; Christiane Garbay; Arnaud Ducruix; Jean-Pierre Vilain
Grb2 promotes reinitiation of meiosis in Xenopus oocytes.
Cellular signalling 2001;13(1):51-5.
2001: Isabelle Léna; H Dh tel; Christiane Garbay; Valérie Daugé
Involvement of D2 dopamine receptors in the opposing effects of two CCK-B agonists in a spatial recognition memory task: role of the anterior nucleus accumbens.
Psychopharmacology 2001;153(2):170-9.
2000: Christiane Garbay; Wang-Qing Liu; Michel Vidal; Bernard P Roques
Inhibitors of Ras signal transduction as antitumor agents.
Biochemical pharmacology 2000;60(8):1165-9.
2000: Bruno Bellier; M E Million; S Danascimento; Hervé MEUDAL; S Kellou; Bernard Maigret; Christiane Garbay
Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode.
Journal of medicinal chemistry 2000;43(20):3614-23.
2000: Marie-France Carlier; Pierre Nioche; I Broutin-L'Hermite; R Boujemaa; Christophe Le Clainche; Coumaran Egile; Christiane Garbay; Arnaud Ducruix; P Sansonetti; Dominique Pantaloni
GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex.
The Journal of biological chemistry 2000;275(29):21946-52.
2000: W Q Liu; M Vidal; Christophe Mathé; Christian Périgaud; Christiane Garbay
Inhibition of the ras-dependent mitogenic pathway by phosphopeptide prodrugs with antiproliferative properties.
Bioorganic & medicinal chemistry letters 2000;10(7):669-72.
1999: Wang-Qing Liu; Michel Vidal; Nohad Gresh; Bernard P Roques; Christiane Garbay
Small peptides containing phosphotyrosine and adjacent alphaMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain.
Journal of medicinal chemistry 1999;42(18):3737-41.
1999: Michel Vidal; N Goudreau; F Cornille; D Cussac; E Gincel; Christiane Garbay
Molecular and cellular analysis of Grb2 SH3 domain mutants: interaction with Sos and dynamin.
Journal of molecular biology 1999;290(3):717-30.
1999: Blandine Pommier; Sophie Da Nascimento; S Dumont; Bruno Bellier; E Million; Christiane Garbay; Bernard P Roques; Florence Noble
The cholecystokininB receptor is coupled to two effector pathways through pertussis toxin-sensitive and -insensitive G proteins.
Journal of neurochemistry 1999;73(1):281-8.
1999: D Cussac; Michel Vidal; corinne leprince; Wang-Qing Liu; F Cornille; G Tiraboschi; Bernard P Roques; Christiane Garbay
A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):31-8.
1998: N Ladurelle; A Sebret; Christiane Garbay; Bernard P Roques; Valérie Daugé
Opposite effects of CCK(B) agonists in grooming behaviour in rats: further evidence for two CCK(B) subsites.
British journal of pharmacology 1998;124(6):1091-8.
1998: Bruno Bellier; Sophie Da Nascimento; Hervé MEUDAL; E Gincel; Bernard P Roques; Christiane Garbay
Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.
Bioorganic & medicinal chemistry letters 1998;8(11):1419-24.
1998: Michel Vidal; J L Montiel; D Cussac; F Cornille; Marc Duchesne; F Parker; B Tocqué; Bernard P Roques; Christiane Garbay
Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. Potential role in the Ras-dependent signaling pathway.
The Journal of biological chemistry 1998;273(9):5343-8.
1997: Bruno Bellier; I McCort-Tranchepain; B Ducos; S Danascimento; Hervé MEUDAL; Florence Noble; Christiane Garbay; Bernard P Roques
Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor on transfected CHO cells.
Journal of medicinal chemistry 1997;40(24):3947-56.
1997: Armand Blommaert; H Dhôtel; B Ducos; C Durieux; N Goudreau; André Bado; Christiane Garbay; Bernard P Roques
Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor.
Journal of medicinal chemistry 1997;40(5):647-58.
1996: J H Weng; André Bado; Christiane Garbay; Bernard P Roques
Novel CCK-B receptor agonists: diketopiperazine analogues derived for CCK4 bioactive conformation.
Regulatory peptides 1996;65(1):3-9.
1996: J H Weng; A G Blommaert; Laurent Moizo; André Bado; B Ducos; A Böhme; Christiane Garbay; Bernard P Roques
Role of N- and C-terminal substituents on the CCK-B agonist-antagonist pharmacological profile of Boc-Trp-Phg-Asp-Nal-NH2 derivatives.
Bioorganic & medicinal chemistry 1996;4(4):563-73.
1996: M E Million; P Mailliett; H Chen; G Bashiardes; J Boiziau; F Parker; A Commerçon; B Tocque; Bernard P Roques; Christiane Garbay
Synthesis and biological evaluation of a new series of phenylhydroquinone derivatives as inhibitors of EGF-R-associated PTK activity.
Anti-cancer drug design 1996;11(2):129-53.
1996: H Chen; G Bashiardes; Patrick Mailliet; A Commercon; F Sounigo; J Boiziau; F Parker; B Tocque; Bernard P Roques; Christiane Garbay
Synthesis and biological evaluation of a series of hydroxybenzylphenylamine derivatives as inhibitors of EGF receptor-associated tyrosine kinase activity.
Anti-cancer drug design 1996;11(1):49-71.
1995: M E Million; J Boiziau; F Parker; B Tocque; Bernard P Roques; Christiane Garbay
Inhibition of the EGF-stimulated cellular proliferation of ER 22 cells by hydroxybiphenyl derivatives.
Journal of medicinal chemistry 1995;38(23):4693-703.
1995: Rafael Maldonado; O Valverde; Christiane Garbay; Bernard P Roques
Protein kinases in the locus coeruleus and periaqueductal gray matter are involved in the expression of opiate withdrawal.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(5):565-75.
1994: N Goudreau; F Cornille; Marc Duchesne; F Parker; B Tocqué; Christiane Garbay; Bernard P Roques
NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos.
Nature structural biology 1994;1(12):898-907.
1994: Nohad Gresh; Brigitte RENE; X W Hui; M C Barsi; B P Roques; Christiane Garbay
Theoretical design, chemical synthesis and footprinting analysis of a novel peptide derivative of the intercalator 7-H pyridocarbazole targeted towards the major groove of DNA.
Journal of biomolecular structure & dynamics 1994;12(1):091-110.
1994: H Chen; J Boiziau; F Parker; Patrick Mailliet; A Commerçon; B Tocque; J B Le Pecq; Bernard P Roques; Christiane Garbay
Structure-activity relationships in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions.
Journal of medicinal chemistry 1994;37(6):845-59.
1994: Y S Yang; Christiane Garbay; Marc Duchesne; F Cornille; N Jullian; N Fromage; B Tocque; Bernard P Roques
Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence.
The EMBO journal 1994;13(6):1270-9.
1987: A Delbarre; Muriel DELEPIERRE; Christiane Garbay; J Igolen; J B Le Pecq; Bernard P Roques
Geometry of the antitumor drug ditercalinium bisintercalated into d(CpGpCpG)2 by 1H NMR.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2155-9.