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Ana García-Sáez

Research Profile

Chemicals & Drugs

Anatomy

Procedures

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Physiology

Membrane Fluidity

Phenomena

Permeability

Co-author Network

Publications

TOP 3
Stephanie Bleicken; Corinna Wagner; Ana J García-Sáez
Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.
Julia P Steringer; Koen Temmerman; Sonja Zacherl; Helena Andreas; Tanmay A M Bharat; Stephanie Bleicken; John A G Briggs; F-Xabier Contreras; Ana J García-Sáez; Mareike Laussmann; Johannes Lechner; Hans-Michael Müller; Walter Nickel
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion.
Stephanie Bleicken; Elena Conte; Ana J García-Sáez; Enrica Bordignon
Dynamic interaction of cBid with detergents, liposomes and mitochondria.

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All Publications

2013: Stephanie Bleicken; Corinna Wagner; Ana J García-Sáez
Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.
Biophysical journal 2013;104(2):421-31.
2012: Julia P Steringer; Koen Temmerman; Sonja Zacherl; Helena Andreas; Tanmay A M Bharat; Stephanie Bleicken; John A G Briggs; F-Xabier Contreras; Ana J García-Sáez; Mareike Laussmann; Johannes Lechner; Hans-Michael Müller; Walter Nickel
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion.
The Journal of biological chemistry 2012;287(33):27659-69.
2012: Stephanie Bleicken; Elena Conte; Ana J García-Sáez; Enrica Bordignon
Dynamic interaction of cBid with detergents, liposomes and mitochondria.
PloS one 2012;7(4):e35910.
2011: Ana J García-Sáez; Heiko Keller; Gregor Anderluh; Sabine B Buschhorn; Kai Simons; Petra Schwille
Oligomerization and pore formation by equinatoxin II inhibit endocytosis and lead to plasma membrane reorganization.
The Journal of biological chemistry 2011;286(43):37768-77.
2011: Beatriz Apellániz; Ana J García-Sáez; Shlomo Nir; José L Nieva
Destabilization exerted by peptides derived from the membrane-proximal external region of HIV-1 gp41 in lipid vesicles supporting fluid phase coexistence.
Biochimica et biophysica acta 2011;1808(7):1797-805.
2010: Beatriz Apellániz; José L Nieva; Petra Schwille; Ana J García-Sáez
All-or-none versus graded: single-vesicle analysis reveals lipid composition effects on membrane permeabilization.
Biophysical journal 2010;99(11):3619-28.
2010: Gustavo Fuertes; Ana J García-Sáez; Santi Esteban-Martín; Diana Giménez; Orlando L Sánchez Muñoz; Petra Schwille; Jesús Salgado
Pores formed by Baxα5 relax to a smaller size and keep at equilibrium.
Biophysical journal 2010;99(9):2917-25.
2010: Christian Klose; Christer S Ejsing; Ana J García-Sáez; Hermann-Josef Kaiser; Julio L Sampaio; Michal A Surma; Andrej Shevchenko; Petra Schwille; Kai Simons
Yeast lipids can phase-separate into micrometer-scale membrane domains.
The Journal of biological chemistry 2010;285(39):30224-32.
2010: Ana J García-Sáez; Petra Schwille
Stability of lipid domains.
FEBS letters 2010;584(9):1653-8.
2010: Beatriz Apellaniz; Ana J García-Sáez; Nerea Huarte; Renate Kunert; Karola Vorauer-Uhl; Hermann Katinger; Petra Schwille; José L Nieva
Confocal microscopy of giant vesicles supports the absence of HIV-1 neutralizing 2F5 antibody reactivity to plasma membrane phospholipids.
FEBS letters 2010;584(8):1591-6.
2010: Ana J García-Sáez; Petra Schwille
Surface analysis of membrane dynamics.
Biochimica et biophysica acta 2010;1798(4):766-76.
2010: Ana J García-Sáez; Gustavo Fuertes; Jacob Suckale; Jesús Salgado
Permeabilization of the outer mitochondrial membrane by Bcl-2 proteins.
Advances in experimental medicine and biology 2010;677():91-105.
2010: Ana J García-Sáez; Dolores C Carrer; Petra Schwille
Fluorescence correlation spectroscopy for the study of membrane dynamics and organization in giant unilamellar vesicles.
Methods in molecular biology (Clifton, N.J.) 2010;606():493-508.
2009: Ana J García-Sáez; Jonas Ries; Mar Orzáez; Enrique Pérez-Payà; Petra Schwille
Membrane promotes tBID interaction with BCL(XL).
Nature structural & molecular biology 2009;16(11):1178-85.
2009: Olena Ivashyna; Ana J García-Sáez; Jonas Ries; Eric T Christenson; Petra Schwille; Paul H Schlesinger
Detergent-activated BAX protein is a monomer.
The Journal of biological chemistry 2009;284(36):23935-46.
2008: Ana J García-Sáez; Petra Schwille
Fluorescence correlation spectroscopy for the study of membrane dynamics and protein/lipid interactions.
Methods (San Diego, Calif.) 2008;46(2):116-22.
2008: Peter Schön; Ana J García-Sáez; Petra Malovrh; Kirsten Bacia; Gregor Anderluh; Petra Schwille
Equinatoxin II permeabilizing activity depends on the presence of sphingomyelin and lipid phase coexistence.
Biophysical journal 2008;95(2):691-8.
2007: Ana J García-Sáez; Salvatore Chiantia; Petra Schwille
Effect of line tension on the lateral organization of lipid membranes.
The Journal of biological chemistry 2007;282(46):33537-44.
2007: Ana J García-Sáez; Petra Schwille
Single molecule techniques for the study of membrane proteins.
Applied microbiology and biotechnology 2007;76(2):257-66.
2007: Ana J García-Sáez; Salvatore Chiantia; Jesús Salgado; Petra Schwille
Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.
Biophysical journal 2007;93(1):103-12.
2006: Ana J García-Sáez; Manuela Coraiola; Mauro Dalla Serra; Ismael Mingarro; Peter Müller; Jesús Salgado
Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores.
The FEBS journal 2006;273(5):971-81.
2005: Ana J García-Sáez; Manuela Coraiola; Mauro Dalla Serra; Ismael Mingarro; Gianfranco Menestrina; Jesús Salgado
Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins.
Biophysical journal 2005;88(6):3976-90.
2004: Ana J García-Sáez; Ismael Mingarro; Enrique Perez-Paya; Jesús Salgado
Membrane-insertion fragments of Bcl-xL, Bax, and Bid.
Biochemistry 2004;43(34):10930-43.
2002: Jesús Salgado; Ana J García-Sáez; Gema Malet; Ismael Mingarro; Enrique Perez-Paya
Peptides in apoptosis research.
Journal of peptide science : an official publication of the European Peptide Society 2002;8(10):543-60.