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Giovanni Appendino

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Behrens Maik; Brockhoff Anne; Batram Claudia; Kuhn Christina; Appendino Giovanni; Meyerhof Wolfgang
The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Paoletti Tiziana; Fallarini Silvia; Gugliesi Francesca; Minassi Alberto; Appendino Giovanni; Lombardi Grazia
Anti-inflammatory and vascularprotective properties of 8-prenylapigenin.
Giangaspero Anna; Ponti Cristina; Pollastro Federica; Del Favero Giorgia; Della Loggia Roberto; Tubaro Aurelia; Appendino Giovanni; Sosa Silvio
Topical anti-inflammatory activity of Eupatilin, a lipophilic flavonoid from mountain wormwood ( Artemisia umbelliformis Lam.).

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All Publications

2009: Behrens Maik; Brockhoff Anne; Batram Claudia; Kuhn Christina; Appendino Giovanni; Meyerhof Wolfgang
The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Journal of agricultural and food chemistry 2009;57(21):9860-6.
2009: Paoletti Tiziana; Fallarini Silvia; Gugliesi Francesca; Minassi Alberto; Appendino Giovanni; Lombardi Grazia
Anti-inflammatory and vascularprotective properties of 8-prenylapigenin.
European journal of pharmacology 2009;620(1-3):120-30.
2009: Giangaspero Anna; Ponti Cristina; Pollastro Federica; Del Favero Giorgia; Della Loggia Roberto; Tubaro Aurelia; Appendino Giovanni; Sosa Silvio
Topical anti-inflammatory activity of Eupatilin, a lipophilic flavonoid from mountain wormwood ( Artemisia umbelliformis Lam.).
Journal of agricultural and food chemistry 2009;57(17):7726-30.
2009: Brunelli Elisa; Pinton Giulia; Bellini Paolo; Minassi Alberto; Appendino Giovanni; Moro Laura
Flavonoid-induced autophagy in hormone sensitive breast cancer cells.
Fitoterapia 2009;80(6):327-32.
2009: Rosa Antonella; Appendino Giovanni; Melis M Paola; Deiana Monica; Atzeri Angela; Alessandra Incani; Minassi Alberto; Dessì M Assunta
Protective effect and relation structure-activity of nonivamide and iododerivatives in several models of lipid oxidation.
Chemico-biological interactions 2009;180(2):183-92.
2009: Vriens Joris; Appendino Giovanni; Nilius Bernd
Pharmacology of vanilloid transient receptor potential cation channels.
Molecular pharmacology 2009;75(6):1262-79.
2009: Appendino Giovanni; Ligresti Alessia; Minassi Alberto; Cascio Maria Grazia; Allarà Marco; Taglialatela-Scafati Orazio; Pertwee Roger G; De Petrocellis Luciano; Di Marzo Vincenzo
Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.
Journal of medicinal chemistry 2009;52(9):3001-9.
2009: Klausen Thomas Kjaer; Pagani Alberto; Minassi Alberto; Ech-Chahad Abdellah; Prenen Jean; Owsianik Grzegorz; Hoffmann Else Kay; Pedersen Stine Falsig; Appendino Giovanni; Nilius Bernd
Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study.
Journal of medicinal chemistry 2009;52(9):2933-9.
2009: Rubiolo Patrizia; Matteodo Maura; Bicchi Carlo; Appendino Giovanni; Gnavi Giorgio; Bertea Cinzia; Maffei Massimo
Chemical and biomolecular characterization of Artemisia umbelliformis Lam., an important ingredient of the alpine liqueur "Genepi".
Journal of agricultural and food chemistry 2009;57(9):3436-43.
2009: Burlando Bruno; Ranzato Elia; Volante Andrea; Appendino Giovanni; Pollastro Federica; Verotta Luisella
Antiproliferative effects on tumour cells and promotion of keratinocyte wound healing by different lichen compounds.
Planta medica 2009;75(6):607-13.
2009: Sánchez-Duffhues Gonzalo; Calzado Marco A; de Vinuesa Amaya García; Appendino Giovanni; Fiebich Bernd L; Loock Ulich; Lefarth-Risse Annette; Krohn Karsten; Muñoz Eduardo
Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells.
Biochemical pharmacology 2009;77(8):1401-9.
2009: Bedoya Luis M; Márquez Nieves; Martínez Natalia; Gutiérrez-Eisman Silvia; Alvarez Amparo; Calzado Marco A; Rojas José M; Appendino Giovanni; Muñoz Eduardo; Alcamí José
SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro.
Biochemical pharmacology 2009;77(6):965-78.
2009: Brunelli Elisa; Pinton Giulia; Chianale Federica; Graziani Andrea; Appendino Giovanni; Moro Laura
8-Prenylnaringenin inhibits epidermal growth factor-induced MCF-7 breast cancer cell proliferation by targeting phosphatidylinositol-3-OH kinase activity.
The Journal of steroid biochemistry and molecular biology 2009;113(3-5):163-70.
2008: Di Nicolantonio Federica; Arena Sabrina; Gallicchio Margherita; Zecchin Davide; Martini Miriam; Flonta Simona Emilia; Stella Giulia Maria; Lamba Simona; Cancelliere Carlotta; Russo Mariangela; Geuna Massimo; Appendino Giovanni; Fantozzi Roberto; Medico Enzo; Bardelli Alberto
Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(52):20864-9.
2008: Fattorusso Ernesto; Luciano Paolo; Romano Adriana; Taglialatela-Scafati Orazio; Appendino Giovanni; Borriello Marianna; Fattorusso Caterina
Stereostructure assignment of medium-sized rings through an NMR-computational combined approach. Application to the new germacranes ketopelenolides C and D.
Journal of natural products 2008;71(12):1988-92.
2008: Sánchez-Duffhues Gonzalo; Calzado Marco A; de Vinuesa Amaya García; Caballero Francisco J; Ech-Chahad Abdellah; Appendino Giovanni; Krohn Karsten; Fiebich Bernd L; Muñoz Eduardo
Denbinobin, a naturally occurring 1,4-phenanthrenequinone, inhibits HIV-1 replication through an NF-kappaB-dependent pathway.
Biochemical pharmacology 2008;76(10):1240-50.
2008: Overk Cassia R; Guo Jian; Chadwick Lucas R; Lantvit Daniel D; Minassi Alberto; Appendino Giovanni; Chen Shao-Nong; Lankin David C; Farnsworth Norman R; Pauli Guido F; van Breemen Richard B; Bolton Judy L
In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.
Chemico-biological interactions 2008;176(1):30-9.
2008: Rosa Antonella; Melis M Paola; Deiana Monica; Atzeri Angela; Appendino Giovanni; Corona Giulia; Incani Alessandra; Loru Debora; Dessì M Assunta
Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation.
Chemistry and physics of lipids 2008;155(1):16-23.
2008: Appendino Giovanni; Gibbons Simon; Giana Anna; Pagani Alberto; Grassi Gianpaolo; Stavri Michael; Smith Eileen; Rahman M Mukhlesur
Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
Journal of natural products 2008;71(8):1427-30.
2008: Minassi Alberto; Giana Anna; Ech-Chahad Abdellah; Appendino Giovanni
A regiodivergent synthesis of ring a C-prenylflavones.
Organic letters 2008;10(11):2267-70.
2008: Rosa Antonella; Atzeri Angela; Deiana Monica; Melis M Paola; Incani Alessandra; Corona Giulia; Loru Debora; Appendino Giovanni; Dessì M Assunta
Protective effect of vanilloids against tert-butyl hydroperoxide-induced oxidative stress in vero cells culture.
Journal of agricultural and food chemistry 2008;56(10):3546-53.
2008: Márquez Nieves; Calzado Marco A; Sánchez-Duffhues Gonzalo; Pérez Moisés; Minassi Alberto; Pagani Alberto; Appendino Giovanni; Diaz Laura; Muñoz-Fernández Maria Angeles; Muñoz Eduardo
Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation.
Biochemical pharmacology 2008;75(6):1370-80.
2008: Medana Claudio; Carbone Francesco; Aigotti Riccardo; Appendino Giovanni; Baiocchi Claudio
Selective analysis of phenolic compounds in propolis by HPLC-MS/MS.
Phytochemical analysis : PCA 2008;19(1):32-9.
2008: Appendino G; Minassi A; Pagani A; Ech-Chahad A
The role of natural products in the ligand deorphanization of TRP channels.
Current pharmaceutical design 2008;14(1):2-17.
2007: De Lucia Maria; Mainieri Francesco; Verotta Luisella; Maffei Massimo; Panzella Lucia; Crescenzi Orlando; Napolitano Alessandra; Barone Vincenzo; Appendino Giovanni; d'Ischia Marco
Nitration versus nitrosation chemistry of menthofuran: remarkable fragmentation and dimerization pathways and expeditious entry into dehydromenthofurolactone.
The Journal of organic chemistry 2007;72(26):10123-9.
2007: Brunelli Elisa; Minassi Alberto; Appendino Giovanni; Moro Laura
8-Prenylnaringenin, inhibits estrogen receptor-alpha mediated cell growth and induces apoptosis in MCF-7 breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2007;107(3-5):140-8.
2007: Monti Monia; Pinotti Mirko; Appendino Giovanni; Dallocchio Franco; Bellini Tiziana; Antognoni Fabiana; Poli Ferruccio; Bernardi Francesco
Characterization of anti-coagulant properties of prenylated coumarin ferulenol.
Biochimica et biophysica acta 2007;1770(10):1437-40.
2007: Brockhoff Anne; Behrens Maik; Massarotti Alberto; Appendino Giovanni; Meyerhof Wolfgang
Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.
Journal of agricultural and food chemistry 2007;55(15):6236-43.
2007: Fattorusso Caterina; Stendardo Emiliano; Appendino Giovanni; Fattorusso Ernesto; Luciano Paolo; Romano Adriana; Taglialatela-Scafati Orazio
Artarborol, a nor-caryophyllane sesquiterpene alcohol from Artemisia arborescens. stereostructure assignment through concurrence of NMR data and computational analysis.
Organic letters 2007;9(12):2377-80.
2007: Appendino Giovanni; Ottino Michela; Marquez Nieves; Bianchi Federica; Giana Anna; Ballero Mauro; Sterner Olov; Fiebich Bernd L; Munoz Eduardo
Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum.
Journal of natural products 2007;70(4):608-12.
2007: Caballero Francisco J; Navarrete Carmen M; Hess Sandra; Fiebich Bernd L; Appendino Giovanni; Macho Antonio; Muñoz Eduardo; Sancho Rocío
The acetaminophen-derived bioactive N-acylphenolamine AM404 inhibits NFAT by targeting nuclear regulatory events.
Biochemical pharmacology 2007;73(7):1013-23.
2007: Verotta Luisella; Appendino Giovanni; Bombardelli Ezio; Brun Reto
In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure-activity study.
Bioorganic & medicinal chemistry letters 2007;17(6):1544-8.
2007: Lombardi Grazia; Miglio Gianluca; Varsaldi Federica; Minassi Alberto; Appendino Giovanni
Oxyhomologation of the amide bond potentiates neuroprotective effects of the endolipid N-palmitoylethanolamine.
The Journal of pharmacology and experimental therapeutics 2007;320(2):599-606.
2007: Rosa Antonella; Deiana Monica; Atzeri Angela; Corona Giulia; Incani Alessandra; Melis M Paola; Appendino Giovanni; Dessì M Assunta
Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum.
Chemico-biological interactions 2007;165(2):117-26.
2007: Appendino Giovanni; Ech-Chahad Abdellah; Minassi Alberto; Bacchiega Sara; De Petrocellis Luciano; Di Marzo Vincenzo
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): the homovanillyl moiety.
Bioorganic & medicinal chemistry letters 2007;17(1):132-5.
2007: Appendino Giovanni; Bacchiega Sara; Minassi Alberto; Cascio Maria Grazia; De Petrocellis Luciano; Di Marzo Vincenzo
The 1,2,3-triazole ring as a peptido- and olefinomimetic element: discovery of click vanilloids and cannabinoids.
Angewandte Chemie (International ed. in English) 2007;46(48):9312-5.
2006: Navarrete Carmen; Sancho Rocío; Caballero Francisco J; Pollastro Federica; Fiebich Bernd L; Sterner Olov; Appendino Giovanni; Muñoz Eduardo
Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activator protein 1 in T lymphocytes.
The Journal of pharmacology and experimental therapeutics 2006;319(1):422-30.
2006: Appendino Giovanni; Maxia Lucia; Bascope Marcelo; Houghton Peter J; Sanchez-Duffhues Gonzalo; Muñoz Eduardo; Sterner Olov
A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida.
Journal of natural products 2006;69(7):1101-4.
2006: Appendino Giovanni; Minassi Alberto; Berton Luca; Moriello Aniello Schiano; Cascio Maria Grazia; De Petrocellis Luciano; Di Marzo Vincenzo
Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity.
Journal of medicinal chemistry 2006;49(7):2333-8.
2006: Márquez Nieves; De Petrocellis Luciano; Caballero Francisco J; Macho Antonio; Schiano-Moriello Aniello; Minassi Alberto; Appendino Giovanni; Muñoz Eduardo; Di Marzo Vincenzo
Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.
Molecular pharmacology 2006;69(4):1373-82.
2006: Appendino Giovanni; Maxia Lucia; Bettoni Piergiorgio; Locatelli Monica; Valdivia Carola; Ballero Mauro; Stavri Michael; Gibbons Simon; Sterner Olov
Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis).
Journal of natural products 2006;69(2):251-4.
2006: Bisogno Tiziana; Cascio Maria Grazia; Saha Bijali; Mahadevan Anu; Urbani Paolo; Minassi Alberto; Appendino Giovanni; Saturnino Carmela; Martin Billy; Razdan Raj; Di Marzo Vincenzo
Development of the first potent and specific inhibitors of endocannabinoid biosynthesis.
Biochimica et biophysica acta 2006;1761(2):205-12.
2006: Appendino Giovanni; Cascio Maria Grazia; Bacchiega Sara; Moriello Aniello Schiano; Minassi Alberto; Thomas Adèle; Ross Ruth; Pertwee Roger; De Petrocellis Luciano; Di Marzo Vincenzo
First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands.
FEBS letters 2006;580(2):568-74.
2006: Appendino Giovanni; Szallasi Arpad
Clinically useful vanilloid receptor TRPV1 antagonists: just around the corner (or too early to tell)?
Progress in medicinal chemistry 2006;44():145-80.
2005: Barboni Luciano; Ballini Roberto; Giarlo Guido; Appendino Giovanni; Fontana Gabriele; Bombardelli Ezio
Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390.
Bioorganic & medicinal chemistry letters 2005;15(23):5182-6.
2005: Rosa Antonella; Deiana Monica; Corona Giulia; Atzeri Angela; Incani Alessandra; Appendino Giovanni; Dessì M Assunta
Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA.
Free radical research 2005;39(11):1155-62.
2005: Feisst Christian; Franke Lutz; Appendino Giovanni; Werz Oliver
Identification of molecular targets of the oligomeric nonprenylated acylphloroglucinols from Myrtus communis and their implication as anti-inflammatory compounds.
The Journal of pharmacology and experimental therapeutics 2005;315(1):389-96.
2005: Sancho Rocío; de la Vega Laureano; Macho Antonio; Appendino Giovanni; Di Marzo Vincenzo; Muñoz Eduardo
Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3990-9.
2005: Appendino Giovanni; Prosperini Simona; Valdivia Carola; Ballero Mauro; Colombano Giampiero; Billington Richard A; Genazzani Armando A; Sterner Olov
SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis.
Journal of natural products 2005;68(8):1213-7.
2005: Appendino Giovanni; Daddario Nives; Minassi Alberto; Moriello Aniello Schiano; De Petrocellis Luciano; Di Marzo Vincenzo
The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination.
Journal of medicinal chemistry 2005;48(14):4663-9.
2005: Campagnuolo Claudio; Fattorusso Ernesto; Petrucci Francesca; Taglialatela-Scafati Orazio; Appendino Giovanni; Marquez Nieves; Muñoz Eduardo
A prenylbisabolane with NF-kappaB inhibiting properties from Cascarilla (Croton eluteria).
Bioorganic & medicinal chemistry 2005;13(13):4238-42.
2005: Appendino Giovanni; Aviello Gabriella; Ballero Mauro; Borrelli Francesca; Fattorusso Ernesto; Petrucci Francesca; Santelia Federico U; Taglialatela-Scafati Orazio
Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis.
Journal of natural products 2005;68(6):853-7.
2005: Calzado Marco A; Lüdi Katharina Schmid; Fiebich Bernd; Ben-Neriah Yinon; Bacher Susanne; Munoz Eduardo; Ballero Mauro; Prosperini Simona; Appendino Giovanni; Schmitz M Lienhard
Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus.
Biochimica et biophysica acta 2005;1729(2):88-93.
2005: Dambruoso Paolo; Bassarello Carla; Bifulco Giuseppe; Appendino Giovanni; Battaglia Arturo; Fontana Gabriele; Gomez-Paloma Luigi
Advances in the universal NMR database approach. 2'-substituted taxanes as probes for an improved protocol of diastereomeric differentiation.
Organic letters 2005;7(6):983-6.
2005: Appendino Giovanni; De Petrocellis Luciano; Trevisani Marcello; Minassi Alberto; Daddario Nives; Moriello Aniello Schiano; Gazzieri David; Ligresti Alessia; Campi Barbara; Fontana Gabriele; Pinna Christian; Geppetti Pierangelo; Di Marzo Vincenzo
Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.
The Journal of pharmacology and experimental therapeutics 2005;312(2):561-70.
2005: Vigone A; Tron G C; Surico D; Baj G; Appendino G; Surico N
Ingenol derivatives inhibit proliferation and induce apoptosis in breast cancer cell lines.
European journal of gynaecological oncology 2005;26(5):526-30.
2004: Appendino Giovanni; Mercalli Enrico; Fuzzati Nicola; Arnoldi Lolita; Stavri Michael; Gibbons Simon; Ballero Mauro; Maxia Andrea
Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).
Journal of natural products 2004;67(12):2108-10.
2004: Márquez Nieves; Sancho Rocío; Ballero Mauro; Bremner Paul; Appendino Giovanni; Fiebich Bernd L; Heinrich Michael; Muñoz Eduardo
Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT.
Planta medica 2004;70(11):1016-21.
2004: Verotta Luisella; Lovaglio Erminio; Sterner Olov; Appendino Giovanni; Bombardelli Ezio
Modulation of chemoselectivity by protein additives. Remarkable effects in the oxidation of hyperforin.
The Journal of organic chemistry 2004;69(23):7869-74.
2004: Appendino Giovanni; Spagliardi Paola; Sterner Olov; Milligan Stuart
Structure--activity relationships of the estrogenic sesquiterpene ester ferutinin. Modification of the terpenoid core.
Journal of natural products 2004;67(9):1557-64.
2004: Donà Massimo; Dell'Aica Isabella; Pezzato Elga; Sartor Luigi; Calabrese Fiorella; Della Barbera Mila; Donella-Deana Arianna; Appendino Giovanni; Borsarini Anna; Caniato Rosy; Garbisa Spiridione
Hyperforin inhibits cancer invasion and metastasis.
Cancer research 2004;64(17):6225-32.
2004: Macho Antonio; Blanco-Molina Magdalena; Spagliardi Paola; Appendino Giovanni; Bremner Paul; Heinrich Michael; Fiebich Bernd L; Muñoz Eduardo
Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line.
Biochemical pharmacology 2004;68(5):875-83.
2004: Sancho Rocío; Márquez Nieves; Gómez-Gonzalo Marta; Calzado Marco A; Bettoni Giorgio; Coiras Maria Teresa; Alcamí José; López-Cabrera Manuel; Appendino Giovanni; Muñoz Eduardo
Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway.
The Journal of biological chemistry 2004;279(36):37349-59.
2004: Szallasi Arpad; Appendino Giovanni
Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse?
Journal of medicinal chemistry 2004;47(11):2717-23.
2004: Appendino Giovanni; Bianchi Federica; Bader Ammar; Campagnuolo Claudio; Fattorusso Ernesto; Taglialatela-Scafati Orazio; Blanco-Molina Magdalena; Macho Antonio; Fiebich Bernd L; Bremner Paul; Heinrich Michael; Ballero Mauro; Muñoz Eduardo
Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin.
Journal of natural products 2004;67(4):532-6.
2004: Danieli Bruno; Giardini Alessandra; Lesma Giordano; Passarella Daniele; Silvani Alessandra; Appendino Giovanni; Noncovich Alain; Fontana Gabriele; Bombardelli Ezio; Sterner Olov
Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids.
Chemistry & biodiversity 2004;1(2):327-45.
2004: Appendino Giovanni; Bettoni Piergiorgio; Noncovich Alain; Sterner Olov; Fontana Gabriele; Bombardelli Ezio; Pera Paula; Bernacki Ralph J
Structure-activity relationships of ring C-secotaxoids. 1. Acylative modifications.
Journal of natural products 2004;67(2):184-8.
2004: Sancho Rocío; Macho Antonio; de La Vega Laureano; Calzado Marco A; Fiebich Bernd L; Appendino Giovanni; Muñoz Eduardo
Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2341-51.
2004: Fattorusso Ernesto; Santelia Federico U; Appendino Giovanni; Ballero Mauro; Taglialatela-Scafati Orazio
Polyoxygenated eudesmanes and trans-chrysanthemanes from the aerial parts of Santolina insularis.
Journal of natural products 2004;67(1):37-41.
2004: Grazia Cascio Maria; Minassi Alberto; Ligresti Alessia; Appendino Giovanni; Burstein Sumner; Di Marzo Vincenzo
A structure-activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase.
Biochemical and biophysical research communications 2004;314(1):192-6.
2003: Appendino Giovanni; Borrelli Francesca; Capasso Raffaele; Campagnuolo Claudio; Fattorusso Ernesto; Petrucci Francesca; Taglialatela-Scafati Orazio
Minor diterpenoids from cascarilla (Croton eluteria Bennet) and evaluation of the cascarilla extract and cascarillin effects on gastric acid secretion.
Journal of agricultural and food chemistry 2003;51(24):6970-4.
2003: Corea Gabriella; Fattorusso Ernesto; Lanzotti Virginia; Taglialatela-Scafati Orazio; Appendino Giovanni; Ballero Mauro; Simon Pierre Noël; Dumontet Charles; Di Pietro Attilio
Modified jatrophane diterpenes as modulators of multidrug resistance from Euphorbia dendroides L.
Bioorganic & medicinal chemistry 2003;11(23):5221-7.
2003: Sancho Rocio; de la Vega Laureano; Appendino Giovanni; Di Marzo Vincenzo; Macho Antonio; Munoz Eduardo
The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway.
British journal of pharmacology 2003;140(6):1035-44.
2003: Rosa Antonella; Deiana Monica; Casu Viviana; Corona Giulia; Appendino Giovanni; Bianchi Federica; Ballero Mauro; Dessì M Assunta
Antioxidant activity of oligomeric acylphloroglucinols from Myrtus communis L.
Free radical research 2003;37(9):1013-9.
2003: Pistelli Luisa; Noccioli Cecilia; Appendino Giovanni; Bianchi Federica; Sterner Olov; Ballero Mauro
Pterocarpans from Bituminaria morisiana and Bituminaria bituminosa.
Phytochemistry 2003;64(2):595-8.
2003: Appendino Giovanni; Harrison Selena; De Petrocellis Luciano; Daddario Nives; Bianchi Federica; Schiano Moriello Aniello; Trevisani Marcello; Benvenuti Francesca; Geppetti Pierangelo; Di Marzo Vincenzo
Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.
British journal of pharmacology 2003;139(8):1417-24.
2003: Corea Gabriella; Fattorusso Ernesto; Lanzotti Virginia; Taglialatela-Scafati Orazio; Appendino Giovanni; Ballero Mauro; Simon Pierre-Noël; Dumontet Charles; Di Pietro Attilio
Jatrophane diterpenes as P-glycoprotein inhibitors. First insights of structure-activity relationships and discovery of a new, powerful lead.
Journal of medicinal chemistry 2003;46(15):3395-402.
2003: Macho Antonio; Sancho Rocío; Minassi Alberto; Appendino Giovanni; Lawen Alfons; Muñoz Eduardo
Involvement of reactive oxygen species in capsaicinoid-induced apoptosis in transformed cells.
Free radical research 2003;37(6):611-9.
2003: Chu Constance J; Huang Susan M; De Petrocellis Luciano; Bisogno Tiziana; Ewing Scott A; Miller Jeffrey D; Zipkin Robert E; Daddario Nives; Appendino Giovanni; Di Marzo Vincenzo; Walker J Michael
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
The Journal of biological chemistry 2003;278(16):13633-9.
2003: Sancho Rocío; Calzado Marco A; Di Marzo Vincenzo; Appendino Giovanni; Muñoz Eduardo
Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway.
Molecular pharmacology 2003;63(2):429-38.
2003: Macho Antonio; Lucena Concepción; Sancho Rocio; Daddario Nives; Minassi Alberto; Muñoz Eduardo; Appendino Giovanni
Non-pungent capsaicinoids from sweet pepper synthesis and evaluation of the chemopreventive and anticancer potential.
European journal of nutrition 2003;42(1):2-9.
2003: Appendino Giovanni; Della Porta Carla; Conseil Gwenaëlle; Sterner Olov; Mercalli Enrico; Dumontet Charles; Di Pietro Attilio
A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).
Journal of natural products 2003;66(1):140-2.
2003: Miglietta Antonella; Gabriel Ludovica; Appendino Giovanni; Bocca Claudia
Biological properties of jatrophane polyesters, new microtubule-interacting agents.
Cancer chemotherapy and pharmacology 2003;51(1):67-74.
2003: Appendino Giovanni; Ligresti Alessia; Minassi Alberto; Daddario Nives; Bisogno Tiziana; Di Marzo Vincenzo
Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors.
Bioorganic & medicinal chemistry letters 2003;13(1):43-6.
2002: Appendino G; Spagliardi P; Ballero M; Seu G
Macrocyclic diterpenoids from Euphorbia hyberna L. subsp. insularis and their reaction with oxyphilic reagents.
Fitoterapia 2002;73(7-8):576-82.
2002: Rosa Antonella; Deiana Monica; Casu Viviana; Paccagnini Stefania; Appendino Giovanni; Ballero Mauro; Dessí M Assunta
Antioxidant activity of capsinoids.
Journal of agricultural and food chemistry 2002;50(25):7396-401.
2002: Appendino Giovanni; Spagliardi Paola; Cravotto Giancarlo; Pocock Victoria; Milligan Stuart
Daucane phytoestrogens: a structure-activity study.
Journal of natural products 2002;65(11):1612-5.
2002: Appendino Giovanni; Minassi Alberto; Daddario Nives; Bianchi Federica; Tron Gian Cesare
Chemoselective esterification of phenolic acids and alcohols.
Organic letters 2002;4(22):3839-41.
2002: He Weidong; Cik Miroslav; Van Puyvelde Luc; Van Dun Jacky; Appendino Giovanni; Lesage Anne; Van der Lindin Ilse; Leysen Josée E; Wouters Walter; Mathenge Simon G; Mudida Francis P; De Kimpe Norbert
Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii.
Bioorganic & medicinal chemistry 2002;10(10):3245-55.
2002: Fattorusso Ernesto; Taglialatela-Scafati Orazio; Campagnuolo Claudio; Santelia Federico U; Appendino Giovanni; Spagliardi Paola
Diterpenoids from Cascarilla (Croton eluteria Bennet).
Journal of agricultural and food chemistry 2002;50(18):5131-8.
2002: Appendino Giovanni; Minassi Alberto; Morello Aniello Schiano; De Petrocellis Luciano; Di Marzo Vincenzo
N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor.
Journal of medicinal chemistry 2002;45(17):3739-45.
2002: Sancho Rocío; Lucena Concepción; Macho Antonio; Calzado Marco A; Blanco-Molina Magdalena; Minassi Alberto; Appendino Giovanni; Muñoz Eduardo
Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-kappaB activation and is a potent antiinflammatory compound in vivo.
European journal of immunology 2002;32(6):1753-63.
2002: He Weidong; Cik Miroslav; Appendino Giovanni; Puyvelde Luc Van; Leysen Josée E; De Kimpe Norbert
Daphnane-type diterpene orthoesters and their biological activities.
Mini reviews in medicinal chemistry 2002;2(2):185-200.
2002: Verotta Luisella; Appendino Giovanni; Belloro Emanuela; Bianchi Federica; Sterner Olov; Lovati Marco; Bombardelli Ezio
Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety.
Journal of natural products 2002;65(4):433-8.
2002: Appendino Giovanni; Bianchi Federica; Minassi Alberto; Sterner Olov; Ballero Mauro; Gibbons Simon
Oligomeric acylphloroglucinols from myrtle (Myrtus communis).
Journal of natural products 2002;65(3):334-8.
2002: Fezza Filomena; Bisogno Tiziana; Minassi Alberto; Appendino Giovanni; Mechoulam Raphael; Di Marzo Vincenzo
Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues.
FEBS letters 2002;513(2-3):294-8.
2001: Blanco-Molina M; Tron G C; Macho A; Lucena C; Calzado M A; Muñoz E; Appendino G
Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway.
Chemistry & biology 2001;8(8):767-78.
2001: Bicchi C; Appendino G; Cordero C; Rubiolo P; Ortelli D; Veuthey J L
HPLC-UV and HPLC-positive-ESI-MS analysis of the diterpenoid fraction from caper spurge (Euphorbia lathyris) seed oil.
Phytochemical analysis : PCA 2001;12(4):255-62.
2001: Appendino G; Tron G C; Jarevång T; Sterner O
Unnatural natural products from the transannular cyclization of lathyrane diterpenes.
Organic letters 2001;3(11):1609-12.
2001: Barboni L; Lambertucci C; Appendino G; Vander Velde D G; Himes R H; Bombardelli E; Wang M; Snyder J P
Synthesis and NMR-driven conformational analysis of taxol analogues conformationally constrained on the C13 side chain.
Journal of medicinal chemistry 2001;44(10):1576-87.
2001: Appendino G; Cravotto G; Sterner O; Ballero M
Oxygenated sesquiterpenoids from a nonpoisonous sardinian chemotype of giant fennel (Ferula communis).
Journal of natural products 2001;64(3):393-5.
2000: He W; Cik M; Lesage A; Van der Linden I; De Kimpe N; Appendino G; Bracke J; Mathenge S G; Mudida F P; Leysen J E; Van Puyvelde L
Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii.
Journal of natural products 2000;63(9):1185-7.
2000: Macho A; Lucena C; Calzado M A; Blanco M; Donnay I; Appendino G; Muñoz E
Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism.
Chemistry & biology 2000;7(7):483-92.
2000: Appendino G; Jakupovic J; Belloro E; Marchesini A
Triterpenoid p-aminobenzoates from the seeds of zucchini.
Fitoterapia 2000;71(3):258-63.
2000: Appendino G; Belloro E; Tron G C; Jakupovic J; Ballero M
Polycyclic diterpenoids from Euphorbia characias.
Fitoterapia 2000;71(2):134-42.
2000: Verotta L; Appendino G; Jakupovic J; Bombardelli E
Hyperforin analogues from St. John's wort (Hypericum perforatum).
Journal of natural products 2000;63(3):412-5.
1999: Szallasi A; Szabó T; Bíró T; Modarres S; Blumberg P M; Krause J E; Cortright D N; Appendino G
Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1.
British journal of pharmacology 1999;128(2):428-34.
1999: Gabetta B; Fuzzati N; Orsini P; Peterlongo F; Appendino G; Vander Velde D G
Paclitaxel analogues from Taxus x media cv. Hicksii.
Journal of natural products 1999;62(2):219-23.
1999: Ballero M; Piu G; Appendino G
Immediate urticaria to Euphorbiaceae.
Allergy 1999;54(1):91-2.
1999: Milanesio M; Ugliengo P; Viterbo D; Appendino G
Ab initio conformational study of the phenylisoserine side chain of paclitaxel.
Journal of medicinal chemistry 1999;42(2):291-9.
1998: Appendino G; Jakupovic S; Tron G C; Jakupovic J; Milon V; Ballero M
Macrocyclic diterpenoids from Euphorbia semiperfoliata.
Journal of natural products 1998;61(6):749-56.
1997: Appendino G; Szallasi A
Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine.
Life sciences 1997;60(10):681-96.
1996: Appendino G; Cravotto G; Palmisano G; Annunziata R; Szallasi A
Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity.
Journal of medicinal chemistry 1996;39(16):3123-31.
1996: Szallasi A; Acs G; Cravotto G; Blumberg P M; Lundberg J M; Appendino G
A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor.
European journal of pharmacology 1996;299(1-3):221-8.
1995: Appendino G
The phytochemistry of the yew tree.
Natural product reports 1995;12(4):349-60.

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