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Adolfo García-Sastre

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Carles Martínez-Romero; Ignacio Mena; Donna M Tscherne; Virginia L Gillespie; Randy A Albrecht; Alan Belicha-Villanueva; Cornelis A M de Haan; Erik de Vries; Adolfo García-Sastre
Substitutions T200A and E227A in the Hemagglutinin of Pandemic 2009 Influenza A Virus Increase Lethality but Decrease Transmission.
Jasmine T Perez; Adolfo García-Sastre; Balaji Manicassamy
Insertion of a GFP Reporter Gene in Influenza Virus.
Daigo Hashimoto; Marylene Leboeuf; Daniel Lucas-Alcaraz; Mary Beth Beasley; Christian D Becker; Scott W Boyer; Andrew Chow; E Camilla Forsberg; Paul S. Frenette; Adolfo García-Sastre; Ginhoux Florent; Melanie Greter; Arthur Mortha; Clara Noizat; Jeremy Price; Peter See; E Richard Stanley; Masato Tanaka; Pearline Teo; Nico van Rooijen; Miriam Merad
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.

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2013: Carles Martínez-Romero; Ignacio Mena; Donna M Tscherne; Virginia L Gillespie; Randy A Albrecht; Alan Belicha-Villanueva; Cornelis A M de Haan; Erik de Vries; Adolfo García-Sastre
Substitutions T200A and E227A in the Hemagglutinin of Pandemic 2009 Influenza A Virus Increase Lethality but Decrease Transmission.
Journal of virology 2013;87(11):6507-11.
2013: Jasmine T Perez; Adolfo García-Sastre; Balaji Manicassamy
Insertion of a GFP Reporter Gene in Influenza Virus.
Current protocols in microbiology 2013;Chapter 15():Unit15G.4.
2013: Daigo Hashimoto; Marylene Leboeuf; Daniel Lucas-Alcaraz; Mary Beth Beasley; Christian D Becker; Scott W Boyer; Andrew Chow; E Camilla Forsberg; Paul S. Frenette; Adolfo García-Sastre; Ginhoux Florent; Melanie Greter; Arthur Mortha; Clara Noizat; Jeremy Price; Peter See; E Richard Stanley; Masato Tanaka; Pearline Teo; Nico van Rooijen; Miriam Merad
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.
Immunity 2013;38(4):792-804.
2013: Adolfo García-Sastre; Ignacio Mena
Novel vaccine strategies against emerging viruses.
Current opinion in virology 2013;3(2):210-6.
2013: Irina Margine; Gerlinde Obermoser; Peter Palese; Karolina Palucka; John J Treanor; Randy A Albrecht; Jacques Banchereau; Adolfo García-Sastre; Hai Rong; A Carson Harrod; Florian Krammer
H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice.
Journal of virology 2013;87(8):4728-37.
2013: Michaela Weber; Christoph Borner; Stéphanie Devignot; Adolfo García-Sastre; Ali Gawanbacht; Matthias Habjan; Ralf Jacob; Georg Kochs; Andreas Rang; Anna Mareike Schmidt; Sophie Veitinger; Friedemann Weber
Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling.
Cell host & microbe 2013;13(3):336-46.
2013: Juliet Morrison; Lubbertus C F Mulder; Giuseppe Pisanelli; Ricardo Rajsbaum; Viviana Simon; Ana Fernandez-Sesma; Maudry Laurent-Rolle; Ana M Maestre; Adolfo García-Sastre
Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.
PLoS pathogens 2013;9(3):e1003265.
2013: Irene Ramos Lopez; Christopher W Seibert; Liset Westera; Dabeiba Bernal-Rubio; Elena Carnero; Adolfo García-Sastre; Ana Fernandez-Sesma
Contribution of double-stranded RNA and CPSF30 binding domains of influenza virus NS1 to the inhibition of type I interferon production and activation of human dendritic cells.
Journal of virology 2013;87(5):2430-40.
2013: Gijs A Versteeg; Ana Fernandez-Sesma; Kyung-Soo Inn; Jae Jung; Ana M Maestre; Ricardo Rajsbaum; Maria Teresa Sánchez-Aparicio; Mude Shi; Julio Valdiviezo; Adolfo García-Sastre
The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors.
Immunity 2013;38(2):384-98.
2013: Adolfo García-Sastre
Cell biology: Beneficial lessons from viruses.
Nature 2013;494(7436):181-2.
2013: Boris M Hartmann; Fernand Hayot; Jingjing Jia; Wenjing Li; Nada Marjanovic; Carles Martínez-Romero; Thomas M Moran; Sonali Patil; Randy A Albrecht; Adolfo García-Sastre; James G Wetmur; Stuart C Sealfon
Mouse dendritic cell (DC) influenza virus infectivity is much lower than that for human DCs and is hemagglutinin subtype dependent.
Journal of virology 2013;87(3):1916-8.
2013: L Martínez-Gil; Adolfo García-Sastre; P H Goff; R Hai; Megan L Shaw; P Palese
A Sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant.
Journal of virology 2013;87(3):1290-300.
2013: Ron A M Fouchier; Adolfo García-Sastre; Yoshihiro Kawaoka
H5N1 virus: Transmission studies resume for avian flu.
Nature 2013;493(7434):609.
2013: Adolfo García-Sastre; Matthew J Evans
miR-122 is more than a shield for the hepatitis C virus genome.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1571-2.
2012: Fabien Ferrage; Adolfo García-Sastre; Estanislao Nistal-Villán; Jenish R Patel; María T Sánchez-Aparicio; Gloria González Aseguinolaza; Angeliki Buku; Pablo De Ioannes; Kaushik Dutta; Aneel K Aggarwal
Structure and dynamics of the second CARD of human RIG-I provide mechanistic insights into regulation of RIG-I activation.
Structure (London, England : 1993) 2012;20(12):2048-61.
2012: Juan Ayllon; Adolfo García-Sastre; Rupert J Russell; Benjamin G Hale
Contribution of NS1 effector domain dimerization to influenza A virus replication and virulence.
Journal of virology 2012;86(23):13095-8.
2012: Adolfo García-Sastre
The neuraminidase of bat influenza viruses is not a neuraminidase.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(46):18635-6.
2012: Julie Helft; Marylene Leboeuf; Balaji Manicassamy; Judith Agudo; Brian D Brown; Adolfo García-Sastre; Pierre Guermonprez; Daigo Hashimoto; Jennifer C Miller; Kenneth M Murphy; Mirco Schmolke; Aymeric Silvin; Miriam Merad
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.
The Journal of clinical investigation 2012;122(11):4037-47.
2012: Chuanling Qiao; Juergen A Richt; Huigang Shen; Chris Ka Pun Mok; Wenbao Qi; Bhupinder Bawa; Ying Chen; Adolfo García-Sastre; Qinfang Liu; Wenjun Ma
Pathogenicity and transmissibility of reassortant H9 influenza viruses with genes from pandemic H1N1 virus.
The Journal of general virology 2012;93(Pt 11):2337-45.
2012: R. Burke Squires; David Suarez; Sam Zaremba; Yun Zhang; Liwei Zhou; Nicole Baumgarth; Jon Deitrich; Adolfo García-Sastre; Victoria Hunt; Edward Klem; Sanjeev Kumar; Christopher N Larsen; Catherine Macken; Jyothi Noronha; Brett E Pickett; Alvin Ramsey; Richard H Scheuermann
Influenza research database: an integrated bioinformatics resource for influenza research and surveillance.
Influenza and other respiratory viruses 2012;6(6):404-16.
2012: Laurence Josset; Michael G Katze; Yoshi Kawoaka; Sara Kelly; Flora Engelmann; Adolfo García-Sastre; Kristen Haberthur; Byung Park; Ilhem Messaoudi
Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza A virus.
Journal of virology 2012;86(20):11115-27.
2012: Amy L Vincent; Richard J Webby; Philip C Gauger; Bruce H Janke; Kelly M Lager; Crystal L Loving; Wenjun Ma; Juergen A Richt; Matthew R Sandbulte; Adolfo García-Sastre
Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine-associated enhanced respiratory disease.
Journal of virology 2012;86(19):10597-605.
2012: Takashi Irie; Yuliang Liu; Elena Carnero; Barbara S Drolet; Adolfo García-Sastre; Ronald N Harty
Cytopathogenesis of vesicular stomatitis virus is regulated by the PSAP motif of M protein in a species-dependent manner.
Viruses 2012;4(9):1605-18.
2012: Ryan A Langlois; Mark A Chua; Adolfo García-Sastre; Andrew Varble; Benjamin R Tenoever
Hematopoietic-specific targeting of influenza A virus reveals replication requirements for induction of antiviral immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(30):12117-22.
2012: Juan Ayllon; Adolfo García-Sastre; Benjamin G Hale
Influenza A viruses and PI3K: are there time, place and manner restrictions?
Virulence 2012;3(4):411-4.
2012: Jens C Krause; Irene Ramos Lopez; Tshidi Tsibane; Terrence M Tumpey; Randy Albrecht; Christopher F Basler; David L Blum; Kathryn M Edwards; Ana Fernandez-Sesma; Adolfo García-Sastre; Chelsey J Huffman; James E Crowe
Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.
Journal of virology 2012;86(11):6334-40.
2012: Wenjun Ma; Wenbao Qi; Chuanling Qiao; Bhupinder Bawa; Ying Chen; Adolfo García-Sastre; Xi Li; Qinfang Liu; Jingqun Ma; Huigang Shen; Richard J Webby; Jürgen A Richt
The neuraminidase and matrix genes of the 2009 pandemic influenza H1N1 virus cooperate functionally to facilitate efficient replication and transmissibility in pigs.
The Journal of general virology 2012;93(Pt 6):1261-8.
2012: Jad Maamary; Natalie Pica; Alan Belicha-Villanueva; Yi-ying Chou; Qinshan Gao; Adolfo García-Sastre; Florian Krammer; Peter Palese
Attenuated influenza virus construct with enhanced hemagglutinin protein expression.
Journal of virology 2012;86(10):5782-90.
2012: Alan Belicha-Villanueva; Dabeiba Bernal-Rubio; Ana Fernandez-Sesma; Jad Maamary; Maria Minguito de la Escalera; Juan R Rodriguez-Madoz; Alina Baum; Adolfo García-Sastre
Recombinant influenza A viruses with enhanced levels of PB1 and PA viral protein expression.
Journal of virology 2012;86(10):5926-30.
2012: Jyothi M Noronha; Brett E Pickett; Mirco Schmolke; R. Burke Squires; Toru Takimoto; Gillian M Air; Summer E Galloway; Adolfo García-Sastre; Benjamin G Hale; Victoria Hunt; Edward Klem; Mengya Liu; Monnie McGee; Richard H Scheuermann
Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction.
Journal of virology 2012;86(10):5857-66.
2012: Juan Ayllon; Benjamin G Hale; Adolfo García-Sastre
Strain-specific contribution of NS1-activated phosphoinositide 3-kinase signaling to influenza A virus replication and virulence.
Journal of virology 2012;86(9):5366-70.
2012: Minxiu Wang; Donna M Tscherne; Michael Caffrey; Adolfo García-Sastre; Christopher McCullough; Li Rong
Residue Y161 of influenza virus hemagglutinin is involved in viral recognition of sialylated complexes from different hosts.
Journal of virology 2012;86(8):4455-62.
2012: Ivan Marazzi; Rab Prinjha; Robert G Roeder; Uwe Schaefer; Chris W Seibert; Randy A Albrecht; Scott Dewell; Adolfo García-Sastre; Jessica S Y Ho; Kate L Jeffrey; Jaehoon Kim; Kevin Lee; Balaji Manicassamy; Alexander Tarakhovsky
Suppression of the antiviral response by an influenza histone mimic.
Nature 2012;483(7390):428-33.
2012: Natalie Pica; Cheryl R Stein; Gene S Tan; Taia T Wang; Jens Wrammert; David Banach; Robert B Belshe; Dirk Eggink; Adolfo García-Sastre; Hai Rong; Florian Krammer; Jens C Krause; Jad Maamary; Thomas Moran; Peter Palese
Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):2573-8.
2012: Liang Zhang; Ling Cai; Priyabrata Das; Jef de Brabander; Xiaoyi Deng; Christian V Forst; Adolfo García-Sastre; David E Levy; Balaji Manicassamy; Margaret A Phillips; Michael Roth; Mirco Schmolke; Benjamin P Tu; Yaming Wang; Beatriz M A Fontoura
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.
The Journal of cell biology 2012;196(3):315-26.
2012: Ron A M Fouchier; Adolfo García-Sastre; Yoshihiro Kawaoka
Pause on avian flu transmission studies.
Nature 2012;481(7382):443.
2012: Ricardo Rajsbaum; Gijs A Versteeg; May K Wang; Randy A Albrecht; Adolfo García-Sastre; Natalya P Maharaj; Estanislao Nistal-Villán; Michaela U Gack
Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
PLoS pathogens 2012;8(11):e1003059.
2012: Luis Martínez-Gil; Mila Brum Ortigoza; Juan Ayllon; Adolfo García-Sastre; Megan L Shaw; Peter Palese
Identification of small molecules with type I interferon inducing properties by high-throughput screening.
PloS one 2012;7(11):e49049.
2012: Matthew M Hufford; Balaji Manicassamy; Graham Richardson; Haixia Zhou; Richard I Enelow; Adolfo García-Sastre; Thomas J Braciale
Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells.
PloS one 2012;7(10):e46581.
2012: Ron A M Fouchier; Adolfo García-Sastre; Yoshihiro Kawaoka
The pause on Avian H5N1 influenza virus transmission research should be ended.
mBio 2012;3(5):.
2012: Samuel E Ward; Katarzyna M Blazewska; Beatriz M A Fontoura; Christian V Forst; Adolfo García-Sastre; Hyun Seok Kim; Kakajan Komurov; Balaji Manicassamy; Charles E McKenna; Saurabh Mendiratta; Michael Roth; Neal Satterly; Mirco Schmolke; Pei-Ling Tsai; Michael A White
Host modulators of H1N1 cytopathogenicity.
PloS one 2012;7(8):e39284.
2012: Adolfo García-Sastre
Working safely with H5N1 viruses.
mBio 2012;3(2):e00049-12.
2012: Diede Oudshoorn; Ricardo Rajsbaum; Maria Teresa Sánchez-Aparicio; Sander van Boheemen; Adolfo García-Sastre; Gijs A Versteeg
HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells.
PloS one 2012;7(1):e29870.
2011: Adolfo García-Sastre
Induction and evasion of type I interferon responses by influenza viruses.
Virus research 2011;162(1-2):12-8.
2011: Natalie Pica; Irene Ramos Lopez; Nicole M Bouvier; Ana Fernandez-Sesma; Adolfo García-Sastre; Arun Iyer; Anice C Lowen; Peter Palese; John Steel
The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses.
Journal of virology 2011;85(23):12825-9.
2011: Kristian M Hargadon; Haixia Zhou; Randy A Albrecht; Haley A Dodd; Adolfo García-Sastre; Thomas J Braciale
Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells.
Journal of virology 2011;85(22):11955-63.
2011: Yi-ying Chou; Adolfo García-Sastre; Randy A Albrecht; Anice C Lowen; Peter Palese; Natalie Pica; Juergen A Richt; Hai Rong
The M segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the guinea pig model.
Journal of virology 2011;85(21):11235-41.
2011: Miguel A Mata; Samuel Peña-Llopis; Michael Roth; Neal Satterly; Mirco Schmolke; Gijs A Versteeg; Shuguang Wei; Michael A White; Noelle Williams; James Brugarolas; Christian V Forst; Doug E Frantz; Adolfo García-Sastre; Beatriz M A Fontoura
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.
Nature chemical biology 2011;7(10):712-9.
2011: Francis V Chisari; Adolfo García-Sastre
Pioneers of pathogenesis: past and present.
Current opinion in virology 2011;1(3):157-9.
2011: Mirco Schmolke; John Steel; Troy Sutton; Zsuzsanna T Varga; Hai Rong; Ben Hale; Balaji Manicassamy; Lindomar Pena; Daniel R Pérez; Adolfo García-Sastre
Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species.
PLoS pathogens 2011;7(8):e1002186.
2011: Hai Rong; Adolfo García-Sastre; David E Swayne; Peter Palese
A reassortment-incompetent live attenuated influenza virus vaccine for protection against pandemic virus strains.
Journal of virology 2011;85(14):6832-43.
2011: Zsuzsanna T Varga; Irene Ramos Lopez; Mirco Schmolke; Ana Fernandez-Sesma; Adolfo García-Sastre; Hai Rong; Peter Palese
The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.
PLoS pathogens 2011;7(6):e1002067.
2011: Donna M Tscherne; Adolfo García-Sastre
An enzymatic assay for detection of viral entry.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2011;Chapter 26():Unit 26.12.
2011: Adrish Sen; Andrea J Pruijssers; Terence S Dermody; Adolfo García-Sastre; Harry B Greenberg
The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3.
Journal of virology 2011;85(8):3717-32.
2011: Erik de Vries; Donna M Tscherne; Marleen J Wienholts; Viviana Cobos-Jiménez; Florine Scholte; Adolfo García-Sastre; Peter J M Rottier; Cornelis de Haan
Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway.
PLoS pathogens 2011;7(3):e1001329.
2011: Alina Baum; Adolfo García-Sastre
Differential recognition of viral RNA by RIG-I.
Virulence 2011;2(2):166-9.
2011: Jad Maamary; Frida Array; Qinshan Gao; Adolfo García-Sastre; Ralph M Steinman; Peter Palese; Godwin Nchinda
Newcastle disease virus expressing a dendritic cell-targeted HIV gag protein induces a potent gag-specific immune response in mice.
Journal of virology 2011;85(5):2235-46.
2011: Sudhir Pai Kasturi; Ioanna Skountzou; Randy A Albrecht; Dimitrios Koutsonanos; Tang Hua; Helder I Nakaya; Rajesh Ravindran; Shelley Stewart; Munir Alam; Marcin Kwissa; Francios VILLINGER; Niren Murthy; John Steel; Joshy Jacob; Robert Jeffrey Hogan; Adolfo García-Sastre; Richard W Compans; Bali Pulendran
Programming the magnitude and persistence of antibody responses with innate immunity.
Nature 2011;470(7335):543-7.
2011: Terrence W James; Natalia Frias-Staheli; John-Paul Bacik; Jesica M Levingston Macleod; Mazdak Khajehpour; Adolfo García-Sastre; Brian L Mark
Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2222-7.
2011: José L Moreno; Mitsumasa Kurita; Terrell Holloway; Javier López; Richard Cadagan; Luis Martinez-Sobrido; Adolfo García-Sastre; Javier González-Maeso
Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT₂A and mGlu₂ receptors in the adult offspring.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(5):1863-72.
2011: Adolfo García-Sastre
2 methylate or not 2 methylate: viral evasion of the type I interferon response.
Nature immunology 2011;12(2):114-5.
2011: Eric Bortz; Adolfo García-Sastre
Predicting the pathogenesis of influenza from genomic response: a step toward early diagnosis.
Genome medicine 2011;3(10):67.
2011: Eric Bortz; Geoffrey Chase; Randy A Albrecht; Jad Maamary; Balaji Manicassamy; Luis Martinez-Sobrido; Martin Schwemmle; John Steel; Liset Westera; Adolfo García-Sastre
Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.
mBio 2011;2(4):.
2011: Hayk Davtyan; Adolfo García-Sastre; Anahit Ghochikyan; Luis Martinez-Sobrido; Nina Movsesyan; Irina Petrushina; Dmitriy Zamarin; Randy A Albrecht; Richard Cadagan; Michael G Agadjanyan
The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease.
Journal of translational medicine 2011;9():127.
2011: Philip S Kerry; Juan Ayllon; Margaret A Taylor; Claudia Hass; Andrew Lewis; Adolfo García-Sastre; Richard E Randall; Ben Hale; Rupert J Russell
A transient homotypic interaction model for the influenza A virus NS1 protein effector domain.
PloS one 2011;6(3):e17946.
2011: Donna M Tscherne; Adolfo García-Sastre
Virulence determinants of pandemic influenza viruses.
The Journal of clinical investigation 2011;121(1):6-13.
2011: Rafael A Medina; Mark Rojas; Astrid Tuin; Stephen Huff; Marcela Ferres; Constanza Martinez-Valdebenito; Paula Godoy; Adolfo García-Sastre; Yuriy Fofanov; John SantaLucia
Development and characterization of a highly specific and sensitive SYBR green reverse transcriptase PCR assay for detection of the 2009 pandemic H1N1 influenza virus on the basis of sequence signatures.
Journal of clinical microbiology 2011;49(1):335-44.
2011: Dhohyung Kim; Luis Martinez-Sobrido; Changsun Choi; Natasha Petroff; Adolfo García-Sastre; Stefan Niewiesk; Thomas Carsillo
Induction of type I interferon secretion through recombinant Newcastle disease virus expressing measles virus hemagglutinin stimulates antibody secretion in the presence of maternal antibodies.
Journal of virology 2011;85(1):200-7.
2010: Sonja Schmid; Markus Mordstein; Georg Kochs; Adolfo García-Sastre; Benjamin R Tenoever
Transcription factor redundancy ensures induction of the antiviral state.
The Journal of biological chemistry 2010;285(53):42013-22.
2010: Sabine Steidle; Luis Martinez-Sobrido; Markus Mordstein; Stefan Lienenklaus; Adolfo García-Sastre; Peter Stäheli; Georg Kochs
Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response.
Journal of virology 2010;84(24):12761-70.
2010: Bin Zhou; Yan Li; Jessica A Belser; Melissa B Pearce; Mirco Schmolke; Anju X Subba; Zhengli Shi; Sherif R Zaki; Dianna M Blau; Adolfo García-Sastre; Terrence M Tumpey; David E Wentworth
NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets.
Vaccine 2010;28(50):8015-25.
2010: Joseph Ashour; Juliet Morrison; Maudry Laurent-Rolle; Alan Belicha-Villanueva; Courtney Ray Plumlee; Dabeiba Bernal-Rubio; Katherine L Williams; Eva Harris; Ana Fernandez-Sesma; Christian Schindler; Adolfo García-Sastre
Mouse STAT2 restricts early dengue virus replication.
Cell host & microbe 2010;8(5):410-21.
2010: Taia T Wang; Gene S Tan; Hai Rong; Natalie Pica; Lily Ngai; Damian C Ekiert; Ian A Wilson; Adolfo García-Sastre; Thomas M Moran; Peter Palese
Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18979-84.
2010: Salin Chutinimitkul; Sander Herfst; John Steel; Anice C Lowen; Jianqiang Ye; Debby van Riel; Eefje J A Schrauwen; Theo M Bestebroer; Björn Koel; david burke; Kyle H Sutherland-Cash; Chris S Whittleston; Colin A Russell; David J Wales; Derek J Smith; Marcel Jonges; Adam Meijer; Marion Koopmans; Guus F Rimmelzwaan; Thijs Kuiken; Albert D M E Osterhaus; Adolfo García-Sastre; Daniel R Perez; Ron A M Fouchier
Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding.
Journal of virology 2010;84(22):11802-13.
2010: Joseph N Brown; Robert E Palermo; Carole R Baskin; Marina Gritsenko; Patrick J Sabourin; James P Long; Carol L Sabourin; Helle Bielefeldt-Ohmann; Adolfo García-Sastre; Randy Albrecht; Terrence M Tumpey; Jon M Jacobs; Richard D Smith; Michael G Katze
Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections.
Journal of virology 2010;84(22):12058-68.
2010: Christopher W Seibert; Michael Kaminski; Jennifer Philipp; Dennis Rubbenstroth; Randy A Albrecht; Folker Schwalm; Silke Stertz; Rafael A Medina; Georg Kochs; Adolfo García-Sastre; Peter Staeheli; Peter Palese
Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the guinea pig and ferret transmission models.
Journal of virology 2010;84(21):11219-26.
2010: Eiji Takayama; Takeshi Ono; Elena Carnero; Saori Umemoto; Yoko Yamaguchi; Atsuhiro Kanayama; Takemi Oguma; Yasuhiro Takashima; Takushi Tadakuma; Adolfo García-Sastre; Yasushi Miyahira
Quantitative and qualitative features of heterologous virus-vector-induced antigen-specific CD8+ T cells against Trypanosoma cruzi infection.
International journal for parasitology 2010;40(13):1549-61.
2010: Alina Baum; Ravi Sachidanandam; Adolfo García-Sastre
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(37):16303-8.
2010: Ivy Widjaja; Erik de Vries; Donna M Tscherne; Adolfo García-Sastre; Peter J M Rottier; Cornelis de Haan
Inhibition of the ubiquitin-proteasome system affects influenza A virus infection at a postfusion step.
Journal of virology 2010;84(18):9625-31.
2010: Wenjun Ma; Kelly M Lager; Porntippa Lekcharoensuk; Eva S Ulery; Bruce H Janke; Alicia Solórzano; Richard J Webby; Adolfo García-Sastre; Juergen A Richt
Viral reassortment and transmission after co-infection of pigs with classical H1N1 and triple-reassortant H3N2 swine influenza viruses.
The Journal of general virology 2010;91(Pt 9):2314-21.
2010: Scott N Mueller; William A Langley; Guimei Li; Adolfo García-Sastre; Richard J Webby; Rafi Ahmed
Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2182-90.
2010: Adolfo García-Sastre; Philippe J Sansonetti
Host-pathogen interactions.
Current opinion in immunology 2010;22(4):425-7.
2010: Junmei Wang; Suresh H Basagoudanavar; Xingyu Wang; Emily Hopewell; Randy Albrecht; Adolfo García-Sastre; Siddharth Balachandran; Amer A Beg
NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1720-9.
2010: Gijs A Versteeg; Adolfo García-Sastre
Viral tricks to grid-lock the type I interferon system.
Current opinion in microbiology 2010;13(4):508-16.
2010: Jianzhong HU; Estanislao Nistal-Villán; Anu Voho; Arnold Ganee; Madhu Kumar; Yaomei Ding; Adolfo García-Sastre; James G Wetmur
A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):424-32.
2010: Mirco Schmolke; Adolfo García-Sastre
Evasion of innate and adaptive immune responses by influenza A virus.
Cellular microbiology 2010;12(7):873-80.
2010: Ben Hale; John Steel; Rafael A Medina; Balaji Manicassamy; Jianqiang Ye; Danielle Hickman; Hai Rong; Mirco Schmolke; Anice C Lowen; Daniel Perez; Adolfo García-Sastre
Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein.
Journal of virology 2010;84(14):6909-22.
2010: Ben Hale; John Steel; Balaji Manicassamy; Rafael A Medina; Jianqiang Ye; Danielle Hickman; Anice C Lowen; Daniel Perez; Adolfo García-Sastre
Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus.
The Journal of general virology 2010;91(Pt 7):1737-42.
2010: Estanislao Nistal-Villán; Michaela U Gack; Gustavo Martínez-Delgado; Natalya P Maharaj; Kyung-Soo Inn; Heyi Yang; Rong Wang; Aneel K Aggarwal; Jae U. Jung; Adolfo García-Sastre
Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production.
The Journal of biological chemistry 2010;285(26):20252-61.
2010: Balaji Manicassamy; santhakumar manicassamy; Alan Belicha-Villanueva; Giuseppe Pisanelli; Bali Pulendran; Adolfo García-Sastre
Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11531-6.
2010: Andrew Varble; Mark A Chua; Jasmine T Perez; Balaji Manicassamy; Adolfo García-Sastre; Benjamin R Tenoever
Engineered RNA viral synthesis of microRNAs.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11519-24.
2010: Jasmine T Perez; Andrew Varble; Ravi Sachidanandam; Ivan Zlatev; Muthiah Manoharan; Adolfo García-Sastre; Benjamin R Tenoever
Influenza A virus-generated small RNAs regulate the switch from transcription to replication.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11525-30.
2010: Kristine M Rose; Ruth Elliott; Luis Martinez-Sobrido; Adolfo García-Sastre; Susan R Weiss
Murine coronavirus delays expression of a subset of interferon-stimulated genes.
Journal of virology 2010;84(11):5656-69.
2010: Hai Rong; Mirco Schmolke; Zsuzsanna T Varga; Balaji Manicassamy; Taia T Wang; Jessica A Belser; Melissa B Pearce; Adolfo García-Sastre; Terrence M Tumpey; Peter Palese
PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models.
Journal of virology 2010;84(9):4442-50.
2010: Alina Baum; Adolfo García-Sastre
Induction of type I interferon by RNA viruses: cellular receptors and their substrates.
Amino acids 2010;38(5):1283-99.
2010: John Steel; Anice C Lowen; Taia T Wang; Mark Yondola; Qinshan Gao; Kester Haye; Adolfo García-Sastre; Peter Palese
Influenza virus vaccine based on the conserved hemagglutinin stalk domain.
mBio 2010;1(1):.
2010: Adolfo García-Sastre
Influenza virus receptor specificity: disease and transmission.
The American journal of pathology 2010;176(4):1584-5.
2010: Maudry Laurent-Rolle; Elena F Boer; Kirk J Lubick; James B Wolfinbarger; Aaron B Carmody; Barry Rockx; Wenjun Liu; Joseph Ashour; W Lesley Shupert; Michael R Holbrook; Alan D T Barrett; Peter W Mason; Marshall E Bloom; Adolfo García-Sastre; Alexander A Khromykh; Sonja Best
The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling.
Journal of virology 2010;84(7):3503-15.
2010: Michaela U Gack; Estanislao Nistal-Villán; Kyung-Soo Inn; Adolfo García-Sastre; Jae U. Jung
Phosphorylation-mediated negative regulation of RIG-I antiviral activity.
Journal of virology 2010;84(7):3220-9.
2010: Renate König; Silke Stertz; Yingyao Zhou; Atsushi Inoue; H-Heinrich Hoffmann; Suchita Bhattacharyya; Judith G Alamares; Donna M Tscherne; Mila B Ortigoza; Yuhong Liang; Qinshan Gao; Shane E Andrews; Sourav Bandyopadhyay; Paul De Jesus; Buu P Tu; Lars Pache; Crystal Shih; Anthony Orth; Ghislain Bonamy; Loren Miraglia; Trey Ideker; Adolfo García-Sastre; John A T Young; Peter Palese; Megan L Shaw; Sumit K Chanda
Human host factors required for influenza virus replication.
Nature 2010;463(7282):813-7.
2010: Scott N Mueller; William A Langley; Elena Carnero; Adolfo García-Sastre; Rafi Ahmed
Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responses.
Journal of virology 2010;84(4):1847-55.
2010: Luis Martinez-Sobrido; Richard Cadagan; John Steel; Christopher F Basler; Peter Palese; Thomas M Moran; Adolfo García-Sastre
Hemagglutinin-pseudotyped green fluorescent protein-expressing influenza viruses for the detection of influenza virus neutralizing antibodies.
Journal of virology 2010;84(4):2157-63.
2010: Shawn Babiuk; Randy Albrecht; Yohannes Berhane; Peter Marszal; Juergen A Richt; Adolfo García-Sastre; John Pasick; Hana Weingartl
1918 and 2009 H1N1 influenza viruses are not pathogenic in birds.
The Journal of general virology 2010;91(Pt 2):339-42.
2010: Donna M Tscherne; Balaji Manicassamy; Adolfo García-Sastre
An enzymatic virus-like particle assay for sensitive detection of virus entry.
Journal of virological methods 2010;163(2):336-43.
2010: Margaret J Wortman; Laura K Hanson; Luis Martinez-Sobrido; Ann E Campbell; Jonas A Nance; Adolfo García-Sastre; Edward M Johnson
Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals.
BMC molecular biology 2010;11():81.
2010: Rafael A Medina; Balaji Manicassamy; Silke Stertz; Christopher W Seibert; Hai Rong; Robert B Belshe; Sharon E Frey; Christopher F Basler; Peter Palese; Adolfo García-Sastre
Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus.
Nature communications 2010;1():28.
2010: Luis Martinez-Sobrido; Adolfo García-Sastre
Generation of recombinant influenza virus from plasmid DNA.
Journal of visualized experiments : JoVE 2010;(42):.
2010: Priya Ranjan; Lakshmi Jayashankar; Varough M Deyde; Hui Zeng; William G Davis; Melissa B Pearce; J Bradford Bowzard; Mary A Hoelscher; Victoria Jeisy-Scott; Mayim E Wiens; Shivaprakash Gangappa; Larisa V Gubareva; Adolfo García-Sastre; Jacqueline M Katz; Terrence M Tumpey; Takashi Fujita; Suryaprakash Sambhara
5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication.
Virology journal 2010;7():102.
2010: Olivo Miotto; A T Heiny; Randy Albrecht; Adolfo García-Sastre; Tin Wee Tan; Thomas J August; Vladimir Brusic
Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains.
PloS one 2010;5(2):e9025.
2010: Balaji Manicassamy; Rafael A Medina; Hai Rong; Tshidi Tsibane; Silke Stertz; Estanislao Nistal-Villán; Peter Palese; Christopher F Basler; Adolfo García-Sastre
Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines.
PLoS pathogens 2010;6(1):e1000745.
2010: Ben Hale; Randy A Albrecht; Adolfo García-Sastre
Innate immune evasion strategies of influenza viruses.
Future microbiology 2010;5(1):23-41.
2010: John Steel; Peter Staeheli; Samira Mubareka; Adolfo García-Sastre; Peter Palese; Anice C Lowen
Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment.
Journal of virology 2010;84(1):21-6.
2009: Georg Kochs; Luis Martinez-Sobrido; Stefan Lienenklaus; Siegfried Weiss; Adolfo García-Sastre; Peter Staeheli
Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.
The Journal of general virology 2009;90(Pt 12):2990-4.
2009: Estanislao Nistal-Villán; Adolfo García-Sastre
New prospects for the rational design of antivirals.
Nature medicine 2009;15(11):1253-4.
2009: Luis Martinez-Sobrido; Sébastien Emonet; Panagiotis Giannakas; Beatrice Cubitt; Adolfo García-Sastre; Juan Carlos de la Torre
Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.
Journal of virology 2009;83(21):11330-40.
2009: Thomas Kuri; Xiaonan Zhang; Matthias Habjan; Luis Martinez-Sobrido; Adolfo García-Sastre; zhenghong yuan; Friedemann Weber
Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation.
The Journal of general virology 2009;90(Pt 11):2686-94.
2009: monique Gannagé; Dorothee Dormann; Randy Albrecht; Jörn Dengjel; Tania Torossi; Patrick C Rämer; Monica Lee; Till Strowig; Frida Arrey; Gina Conenello; Marc Pypaert; Jens Andersen; Adolfo García-Sastre; Christian Münz
Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes.
Cell host & microbe 2009;6(4):367-80.
2009: Rosalind Billharz; Hui Zeng; Sean C Proll; Marcus J Korth; Sharon Lederer; Randy Albrecht; Alan G Goodman; Elizabeth Rosenzweig; Terrence M Tumpey; Adolfo García-Sastre; Michael G Katze
The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways.
Journal of virology 2009;83(20):10557-70.
2009: Kester Haye; Svetlana Burmakina; Thomas Moran; Adolfo García-Sastre; Ana Fernandez-Sesma
The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells.
Journal of virology 2009;83(13):6849-62.
2009: David N Nguyen; Phillip Kim; Luis Martinez-Sobrido; Brett Beitzel; Adolfo García-Sastre; Robert Langer; Daniel G Anderson
A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery.
Biotechnology and bioengineering 2009;103(4):664-75.
2009: Bianca Dauber; Luis Martinez-Sobrido; Jana Schneider; Hai Rong; Zoe Waibler; Ulrich Kalinke; Adolfo García-Sastre; Thorsten Wolff
Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR.
PLoS pathogens 2009;5(6):e1000473.
2009: Joseph Ashour; Maudry Laurent-Rolle; Pei-Yong Shi; Adolfo García-Sastre
NS5 of dengue virus mediates STAT2 binding and degradation.
Journal of virology 2009;83(11):5408-18.
2009: Dmitriy Zamarin; A Vigil; K Kelly; Adolfo García-Sastre; Yuman Fong
Genetically engineered Newcastle disease virus for malignant melanoma therapy.
Gene therapy 2009;16(6):796-804.
2009: Michaela U Gack; Randy Allen Albrecht; Tomohiko Urano; Kyung-Soo Inn; I-Chueh Huang; Elena Carnero; Michael Farzan; Satoshi Inoue; Jae U. Jung; Adolfo García-Sastre
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
Cell host & microbe 2009;5(5):439-49.
2009: Hana Weingartl; Randy A Albrecht; Kelly M Lager; Shawn Babiuk; Peter Marszal; James Neufeld; Carissa Embury-Hyatt; Porntippa Lekcharoensuk; Terrence M Tumpey; Adolfo García-Sastre; Juergen A Richt
Experimental infection of pigs with the human 1918 pandemic influenza virus.
Journal of virology 2009;83(9):4287-96.
2009: Dmitriy Zamarin; Luis Martinez-Sobrido; Kaitlyn Kelly; Mena Mansour; Gang Sheng; Adam Vigil; Adolfo García-Sastre; Peter Palese; Yuman Fong
Enhancement of oncolytic properties of recombinant newcastle disease virus through antagonism of cellular innate immune responses.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(4):697-706.
2009: Anice C Lowen; John Steel; Samira Mubareka; Elena Carnero; Adolfo García-Sastre; Peter Palese
Blocking interhost transmission of influenza virus by vaccination in the guinea pig model.
Journal of virology 2009;83(7):2803-18.
2009: Samira Mubareka; Anice C Lowen; John Steel; Allan L Coates; Adolfo García-Sastre; Peter Palese
Transmission of influenza virus via aerosols and fomites in the guinea pig model.
The Journal of infectious diseases 2009;199(6):858-65.
2009: Carole R Baskin; Helle Bielefeldt-Ohmann; Terrence M Tumpey; Patrick J Sabourin; James P Long; Adolfo García-Sastre; Airn-E Tolnay; Randy Albrecht; John A Pyles; Pam H Olson; Lauri D Aicher; Elizabeth R Rosenzweig; Kaja Murali-Krishna; Edward A Clark; Mark S Kotur; Jamie L Fornek; Sean C Proll; Robert E Palermo; Carol L Sabourin; Michael G Katze
Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3455-60.
2009: Neal Van Hoeven; Claudia Pappas; Jessica A Belser; Taronna R Maines; Hui Zeng; Adolfo García-Sastre; Ram Sasisekharan; Jacqueline M Katz; Terrence M Tumpey
Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3366-71.
2009: John Steel; Anice C Lowen; Lindomar Pena; Matthew Angel; Alicia Solórzano; Randy Albrecht; Daniel Perez; Adolfo García-Sastre; Peter Palese
Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza.
Journal of virology 2009;83(4):1742-53.
2009: Shannon L Taylor; Natalia Frias-Staheli; Adolfo García-Sastre; Connie S Schmaljohn
Hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B.
Journal of virology 2009;83(3):1271-9.
2009: Donna M Tscherne; Adolfo García-Sastre
Recent strategies to identify broadly neutralizing antibodies against influenza A virus.
F1000 biology reports 2009;1():12.
2009: Juergen A Richt; Adolfo García-Sastre
Attenuated influenza virus vaccines with modified NS1 proteins.
Current topics in microbiology and immunology 2009;333():177-95.
2009: Caroline Lai; Jessica J Struckhoff; Jana Schneider; Luis Martinez-Sobrido; Thorsten Wolff; Adolfo García-Sastre; Dong-Er Zhang; Deborah J Lenschow
Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.
Journal of virology 2009;83(2):1147-51.
2009: Elena Carnero; Wenjing Li; Antonio V Borderia; Bruno Moltedo; Thomas Moran; Adolfo García-Sastre
Optimization of human immunodeficiency virus gag expression by newcastle disease virus vectors for the induction of potent immune responses.
Journal of virology 2009;83(2):584-97.
2008: Hai Rong; Luis Martinez-Sobrido; Kathryn A Fraser; Juan Ayllon; Adolfo García-Sastre; Peter Palese
Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach.
Journal of virology 2008;82(21):10580-90.
2008: Adam Vigil; Osvaldo Martinez; Mark A Chua; Adolfo García-Sastre
Recombinant Newcastle disease virus as a vaccine vector for cancer therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(11):1883-90.
2008: Junnie Yu; Michael Gallegos; Florentina Marches; Gerard Zurawski; Octavio Ramilo; Adolfo García-Sastre; Jacques Banchereau; A Karolina Palucka
Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines.
Blood 2008;112(9):3671-8.
2008: Cesar Munoz-Fontela; Salvador Macip; Luis Martinez-Sobrido; Lauren Brown; Joseph Ashour; Adolfo García-Sastre; Sam W Lee; Stuart A Aaronson
Transcriptional role of p53 in interferon-mediated antiviral immunity.
The Journal of experimental medicine 2008;205(8):1929-38.
2008: Shixia Wang; Chris Parker; Jessica Taaffe; Alicia Solórzano; Adolfo García-Sastre; Shan Lu
Heterologous HA DNA vaccine prime--inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses.
Vaccine 2008;26(29-30):3626-33.
2008: Lan Wu; Tian-Gui Huang; Marcia Meseck; Jennifer Altomonte; Oliver Ebert; Katsunori Shinozaki; Adolfo García-Sastre; John Fallon; John Mandeli; Savio L C Woo
rVSV(M Delta 51)-M3 is an effective and safe oncolytic virus for cancer therapy.
Human gene therapy 2008;19(6):635-47.
2008: Jan Dittmann; Silke Stertz; Daniel Grimm; John Steel; Adolfo García-Sastre; Otto Haller; Georg Kochs
Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase.
Journal of virology 2008;82(7):3624-31.
2008: Claudia Pappas; Patricia V Aguilar; Christopher F Basler; Alicia Solórzano; Hui Zeng; Lucy A Perrone; Peter Palese; Adolfo García-Sastre; Jacqueline M Katz; Terrence M Tumpey
Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):3064-9.
2008: John Steel; Svetlana V Burmakina; Colleen Thomas; Erica Spackman; Adolfo García-Sastre; David E Swayne; Peter Palese
A combination in-ovo vaccine for avian influenza virus and Newcastle disease virus.
Vaccine 2008;26(4):522-31.
2008: Lucy A Perrone; Julie K Plowden; Adolfo García-Sastre; Jacqueline M Katz; Terrence M Tumpey
H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice.
PLoS pathogens 2008;4(8):e1000115.
2008: Ching-Hung Shen; Qing Ge; Oezcan Talay; Herman N Eisen; Adolfo García-Sastre; Jianzhu Chen
Loss of IL-7R and IL-15R expression is associated with disappearance of memory T cells in respiratory tract following influenza infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):171-8.
2008: Ian A Cockburn; Sumana Chakravarty; Michael Overstreet; Adolfo García-Sastre; Fidel Zavala
Memory CD8+ T cell responses expand when antigen presentation overcomes T cell self-regulation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):64-71.
2008: Jennifer Altomonte; Lan Wu; Li Chen; Marcia Meseck; Oliver Ebert; Adolfo García-Sastre; John Fallon; Savio Lc Woo
Exponential enhancement of oncolytic vesicular stomatitis virus potency by vector-mediated suppression of inflammatory responses in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):146-53.
2008: Yueh-Ming Loo; Jamie L Fornek; Nanette Crochet; Gagan Bajwa; Olivia Perwitasari; Luis Martinez-Sobrido; Shizuo Akira; Michelle A Gill; Adolfo García-Sastre; Michael G Katze; Michael Gale
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Journal of virology 2008;82(1):335-45.
2007: Natalia Frias-Staheli; Nadia V Giannakopoulos; Marjolein Kikkert; Shannon L Taylor; Anne Bridgen; Jason Paragas; Juergen A Richt; Raymond R Rowland; Connie S Schmaljohn; Deborah J Lenschow; Eric J Snijder; Adolfo García-Sastre; Herbert W Virgin
Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses.
Cell host & microbe 2007;2(6):404-16.
2007: Amy L Vincent; Wenjun Ma; Kelly M Lager; Bruce H Janke; Richard J Webby; Adolfo García-Sastre; Juergen A Richt
Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine.
Vaccine 2007;25(47):7999-8009.
2007: Luis Martinez-Sobrido; Panagiotis Giannakas; Beatrice Cubitt; Adolfo García-Sastre; Juan Carlos de la Torre
Differential inhibition of type I interferon induction by arenavirus nucleoproteins.
Journal of virology 2007;81(22):12696-703.
2007: Carole R Baskin; Helle Bielefeldt-Ohmann; Adolfo García-Sastre; Terrence M Tumpey; Neal Van Hoeven; Victoria S Carter; Matthew J Thomas; Sean C Proll; Alicia Solórzano; R Billharz; Jamie L Fornek; S Thomas; C-H Chen; E A Clark; Kaja Murali-Krishna; Michael G Katze
Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus.
Journal of virology 2007;81(21):11817-27.
2007: Terrence M Tumpey; Kristy Szretter; Neal Van Hoeven; Jacqueline M Katz; Georg Kochs; Otto Haller; Adolfo García-Sastre; Peter Staeheli
The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses.
Journal of virology 2007;81(19):10818-21.
2007: Naotake Tsuda; David Z Chang; Takashi Mine; Clay L Efferson; Adolfo García-Sastre; Xinhui Wang; Soldano Ferrone; Constantin G Ioannides
Taxol increases the amount and T cell activating ability of self-immune stimulatory multimolecular complexes found in ovarian cancer cells.
Cancer research 2007;67(17):8378-87.
2007: Adam Vigil; Man-Seong Park; Osvaldo Martinez; Mark A Chua; Sa Xiao; Jerome F Cros; Luis Martinez-Sobrido; Savio L C Woo; Adolfo García-Sastre
Use of reverse genetics to enhance the oncolytic properties of Newcastle disease virus.
Cancer research 2007;67(17):8285-92.
2007: Takashi Irie; Elena Carnero; Atsushi Okumura; Adolfo García-Sastre; Ronald N Harty
Modifications of the PSAP region of the matrix protein lead to attenuation of vesicular stomatitis virus in vitro and in vivo.
The Journal of general virology 2007;88(Pt 9):2559-67.
2007: Phenix-Lan Quan; Gustavo Palacios; Omar Jabado; Sean Conlan; David L Hirschberg; Francisco Pozo; Philippa J M Jack; Daniel Cisterna; Neil Renwick; Jeffrey Hui; Andrew Drysdale; Rachel Amos-Ritchie; Elsa Baumeister; Vilma L Savy; Kelly M Lager; Juergen A Richt; David B Boyle; Adolfo García-Sastre; Inmaculada Casas; Pilar Perez-Breña; Thomas Briese; W Ian Lipkin
Detection of respiratory viruses and subtype identification of influenza A viruses by GreeneChipResp oligonucleotide microarray.
Journal of clinical microbiology 2007;45(8):2359-64.
2007: Alexander Ghanem; Daniel Mayer; Geoffrey Chase; Werner Tegge; Ronald Frank; Georg Kochs; Adolfo García-Sastre; Martin Schwemmle
Peptide-mediated interference with influenza A virus polymerase.
Journal of virology 2007;81(14):7801-4.
2007: Jessica Roth-Cross; Luis Martinez-Sobrido; Erin P Scott; Adolfo García-Sastre; Susan R Weiss
Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels.
Journal of virology 2007;81(13):7189-99.
2007: Georg Kochs; Adolfo García-Sastre; Luis Martinez-Sobrido
Multiple anti-interferon actions of the influenza A virus NS1 protein.
Journal of virology 2007;81(13):7011-21.
2007: Carlos R Escalante; Estanislao Nistal-Villán; Leyi Shen; Adolfo García-Sastre; Aneel K Aggarwal
Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer.
Molecular cell 2007;26(5):703-16.
2007: Xingyu Wang; Sofia Hussain; Emilie-Jeanne Wang; Xiuyan Wang; Ming O Li; Adolfo García-Sastre; Amer A Beg
Lack of essential role of NF-kappa B p50, RelA, and cRel subunits in virus-induced type 1 IFN expression.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6770-6.
2007: Silke Stertz; Mike Reichelt; Martin Spiegel; Thomas Kuri; Luis Martinez-Sobrido; Adolfo García-Sastre; Friedemann Weber; Georg Kochs
The intracellular sites of early replication and budding of SARS-coronavirus.
Virology 2007;361(2):304-15.
2007: FRANCESC PUIG-BASAGOITI; Mark Tilgner; Corey J Bennett; Yangsheng Zhou; Jorge L Muñoz-Jordán; Adolfo García-Sastre; Kristen A Bernard; Pei-Yong Shi
A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis.
Virology 2007;361(1):229-41.
2007: Daniel Grimm; Peter Staeheli; Martin Hufbauer; Iris Koerner; Luis Martinez-Sobrido; Alicia Solórzano; Adolfo García-Sastre; Otto Haller; Georg Kochs
Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6806-11.
2007: Benjamin R Tenoever; Sze-Ling Ng; Mark A Chua; Sarah M McWhirter; Adolfo García-Sastre; Tom Maniatis
Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity.
Science (New York, N.Y.) 2007;315(5816):1274-8.
2007: Terrence M Tumpey; Taronna R Maines; Neal Van Hoeven; Laurel Glaser; Alicia Solórzano; Claudia Pappas; Nancy J Cox; David E Swayne; Peter Palese; Jacqueline M Katz; Adolfo García-Sastre
A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission.
Science (New York, N.Y.) 2007;315(5812):655-9.
2007: Daniel Mayer; Kaaweh Molawi; Luis Martinez-Sobrido; Alexander Ghanem; Stefan Thomas; Sacha Baginsky; Jonas Grossmann; Adolfo García-Sastre; Martin Schwemmle
Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches.
Journal of proteome research 2007;6(2):672-82.
2007: Deborah J Lenschow; Caroline Lai; Natalia Frias-Staheli; Nadia V Giannakopoulos; Andrew Lutz; Thorsten Wolff; Anna Osiak; Beth Levine; Robert E Schmidt; Adolfo García-Sastre; David A Leib; Andrew Pekosz; Klaus-Peter Knobeloch; Ivan Horak; Herbert W Virgin
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1371-6.
2007: Christopher F Basler; Adolfo García-Sastre
Sensing RNA virus infections.
Nature chemical biology 2007;3(1):20-1.
2007: Masaki Mibayashi; Luis Martinez-Sobrido; Yueh-Ming Loo; Washington B Cárdenas; Michael Gale; Adolfo García-Sastre
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus.
Journal of virology 2007;81(2):514-24.
2006: Shixia Wang; Jessica Taaffe; Christopher Parker; Alicia Solórzano; Hong Cao; Adolfo García-Sastre; Shan Lu
Hemagglutinin (HA) proteins from H1 and H3 serotypes of influenza A viruses require different antigen designs for the induction of optimal protective antibody responses as studied by codon-optimized HA DNA vaccines.
Journal of virology 2006;80(23):11628-37.
2006: Juergen A Richt; Porntippa Lekcharoensuk; Kelly M Lager; Amy L Vincent; Christina M Loiacono; Bruce H Janke; Wai-Hong Wu; Kyoung-Jin Yoon; Richard J Webby; Alicia Solórzano; Adolfo García-Sastre
Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine.
Journal of virology 2006;80(22):11009-18.
2006: Tracey Baas; Carole R Baskin; Deborah L Diamond; Adolfo García-Sastre; Helle Bielefeldt-Ohmann; Terrence M Tumpey; Matthew J Thomas; Victoria S Carter; Thomas H Teal; Neal Van Hoeven; Sean C Proll; Jon M Jacobs; Z R Caldwell; Marina A Gritsenko; Renee R Hukkanen; David G Camp; Richard D Smith; Michael G Katze
Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics.
Journal of virology 2006;80(21):10813-28.
2006: Wing-Pui Kong; Chantelle Ahlenstiel; Zhi-Yong Yang; Chih-Jen Wei; Ling Xu; Adolfo García-Sastre; Terrence M Tumpey; Gary Nabel
Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(43):15987-91.
2006: John C Kash; Terrence M Tumpey; Sean C Proll; Victoria S Carter; Olivia Perwitasari; Matthew J Thomas; Christopher F Basler; Peter Palese; Jeffery Taubenberger; Adolfo García-Sastre; David E Swayne; Michael G Katze
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus.
Nature 2006;443(7111):578-81.
2006: Luis Martinez-Sobrido; Elina I Zúñiga; Debralee Rosario; Adolfo García-Sastre; Juan Carlos de la Torre
Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.
Journal of virology 2006;80(18):9192-9.
2006: Ana Fernandez-Sesma; Svetlana Marukian; Barbara J Ebersole; Dorothy Kaminski; Man-Seong Park; Tony Yuen; Stuart C Sealfon; Adolfo García-Sastre; Thomas M Moran
Influenza virus evades innate and adaptive immunity via the NS1 protein.
Journal of virology 2006;80(13):6295-304.
2006: Anice C Lowen; Samira Mubareka; Terrence M Tumpey; Adolfo García-Sastre; Peter Palese
The guinea pig as a transmission model for human influenza viruses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9988-92.
2006: Man-Seong Park; John Steel; Adolfo García-Sastre; David E Swayne; Peter Palese
Engineered viral vaccine constructs with dual specificity: avian influenza and Newcastle disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8203-8.
2006: Adolfo García-Sastre; Christine A Biron
Type 1 interferons and the virus-host relationship: a lesson in détente .
Science (New York, N.Y.) 2006;312(5775):879-82.
2006: Laurel Glaser; Dmitriy Zamarin; Helen M Acland; Erica Spackman; Peter Palese; Adolfo García-Sastre; Deepanker Tewari
Sequence analysis and receptor specificity of the hemagglutinin of a recent influenza H2N2 virus isolated from chicken in North America.
Glycoconjugate journal 2006;23(1-2):93-9.
2006: Luis Martinez-Sobrido; Negin Vaghefi; Ana Fernandez-Sesma; Jerome Cros; Sara E Mertz; Nancy A Jewell; Sue Hammond; Emilio Flano; Russell K Durbin; Adolfo García-Sastre; Joan E Durbin
Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector.
Journal of virology 2006;80(3):1130-9.
2006: Simon M Carr; Elena Carnero; Adolfo García-Sastre; George G Brownlee; Ervin Fodor
Characterization of a mitochondrial-targeting signal in the PB2 protein of influenza viruses.
Virology 2006;344(2):492-508.
2006: Adolfo García-Sastre
Antiviral response in pandemic influenza viruses.
Emerging infectious diseases 2006;12(1):44-7.
2006: Clay L Efferson; Naotake Tsuda; Kouichiro Kawano; Estanislao Nistal-Villán; Shankhar Sellappan; Dihua Yu; James L Murray; Adolfo García-Sastre; Constantin G Ioannides
Prostate tumor cells infected with a recombinant influenza virus expressing a truncated NS1 protein activate cytolytic CD8+ cells to recognize noninfected tumor cells.
Journal of virology 2006;80(1):383-94.
2005: Terrence M Tumpey; Adolfo García-Sastre; Jeffery Taubenberger; Peter Palese; David E Swayne; Mary J Pantin-Jackwood; Stacey Schultz-Cherry; Alicia Solórzano; Nico van Rooijen; Jacqueline M Katz; Christopher F Basler
Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice.
Journal of virology 2005;79(23):14933-44.
2005: Terrence M Tumpey; Christopher F Basler; Patricia V Aguilar; Hui Zeng; Alicia Solórzano; David E Swayne; Nancy J Cox; Jacqueline M Katz; Jeffery Taubenberger; Peter Palese; Adolfo García-Sastre
Characterization of the reconstructed 1918 Spanish influenza pandemic virus.
Science (New York, N.Y.) 2005;310(5745):77-80.
2005: Ana M Falcón; Ana Fernandez-Sesma; Yurie Nakaya; Thomas M Moran; Juan Ortín; Adolfo García-Sastre
Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins.
The Journal of general virology 2005;86(Pt 10):2817-21.
2005: Dmitriy Zamarin; Adolfo García-Sastre; Xiaoyao Xiao; Rong Wang; Peter Palese
Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.
PLoS pathogens 2005;1(1):e4.
2005: Laurel Glaser; James Stevens; Dmitriy Zamarin; Ian A Wilson; Adolfo García-Sastre; Terrence M Tumpey; Christopher F Basler; Jeffery Taubenberger; Peter Palese
A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity.
Journal of virology 2005;79(17):11533-6.
2005: Michelle Quinlivan; Dmitriy Zamarin; Adolfo García-Sastre; Ann Cullinane; Thomas Chambers; Peter Palese
Attenuation of equine influenza viruses through truncations of the NS1 protein.
Journal of virology 2005;79(13):8431-9.
2005: Jorge L Muñoz-Jordán; Maudry Laurent-Rolle; Joseph Ashour; Luis Martinez-Sobrido; Mundrigi Ashok; W Ian Lipkin; Adolfo García-Sastre
Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses.
Journal of virology 2005;79(13):8004-13.
2005: Svetlana V Bourmakina; Adolfo García-Sastre
The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells.
Journal of virology 2005;79(12):7926-32.
2005: Alicia Solórzano; Richard J Webby; Kelly M Lager; Bruce H Janke; Adolfo García-Sastre; Juergen A Richt
Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs.
Journal of virology 2005;79(12):7535-43.
2005: Andrea Bertolotti-Ciarlet; Jonathan Smith; Karin Strecker; Jason Paragas; Louis A Altamura; Jeanne M McFalls; Natalia Frias-Stäheli; Adolfo García-Sastre; Connie S Schmaljohn; Robert W Doms
Cellular localization and antigenic characterization of crimean-congo hemorrhagic fever virus glycoproteins.
Journal of virology 2005;79(10):6152-61.
2005: Clay L Efferson; Kouichiro Kawano; Naotake Tsuda; Peter Palese; Adolfo García-Sastre; Constantin G Ioannides
Stimulation of human T cells by an influenza A vector expressing a CTL epitope from the HER-2/neu protooncogene results in higher numbers of antigen-specific TCRhi cells than stimulation with peptide. Divergent roles of IL-2 and IL-15.
Anticancer research 2005;25(2A):715-24.
2005: Jerome F Cros; Adolfo García-Sastre; Peter Palese
An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein.
Traffic (Copenhagen, Denmark) 2005;6(3):205-13.
2005: Martin Spiegel; Andreas Pichlmair; Luis Martinez-Sobrido; Jerome F Cros; Adolfo García-Sastre; Otto Haller; Friedemann Weber
Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.
Journal of virology 2005;79(4):2079-86.
2005: Fernando Marcos; Laura Ferreira; Jerome F Cros; Man-Seong Park; Takaaki Nakaya; Adolfo García-Sastre; Enrique Villar
Mapping of the RNA promoter of Newcastle disease virus.
Virology 2005;331(2):396-406.
2005: Stephanie Jennings; Luis Martinez-Sobrido; Adolfo García-Sastre; Friedemann Weber; Georg Kochs
Thogoto virus ML protein suppresses IRF3 function.
Virology 2005;331(1):63-72.
2005: Christopher F Basler; Adolfo García-Sastre; Peter Palese
A novel paramyxovirus?
Emerging infectious diseases 2005;11(1):108-12.
2004: Nicola R Donelan; Bianca Dauber; Xiuyan Wang; Christopher F Basler; Thorsten Wolff; Adolfo García-Sastre
The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation.
Journal of virology 2004;78(21):11574-82.
2004: Carole R Baskin; Adolfo García-Sastre; Terrence M Tumpey; Helle Bielefeldt-Ohmann; Victoria S Carter; Estanislao Nistal-Villán; Michael G Katze
Integration of clinical data, pathology, and cDNA microarrays in influenza virus-infected pigtailed macaques (Macaca nemestrina).
Journal of virology 2004;78(19):10420-32.
2004: John C Kash; Christopher F Basler; Adolfo García-Sastre; Victoria S Carter; Rosalind Billharz; David E Swayne; Ronald Przygodzki; Jeffery Taubenberger; Michael G Katze; Terrence M Tumpey
Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus.
Journal of virology 2004;78(17):9499-511.
2004: Yurie Nakaya; Takaaki Nakaya; Man-Seong Park; Jerome F Cros; Jiro Imanishi; Peter Palese; Adolfo García-Sastre
Induction of cellular immune responses to simian immunodeficiency virus gag by two recombinant negative-strand RNA virus vectors.
Journal of virology 2004;78(17):9366-75.
2004: William H Vecino; Natalie M Quanquin; Luis Martinez-Sobrido; Ana Fernandez-Sesma; Adolfo García-Sastre; William R. Jacobs Jr.; Glenn Fennelly
Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge.
Virology 2004;325(2):192-9.
2004: Megan L Shaw; Adolfo García-Sastre; Peter Palese; Christopher F Basler
Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively.
Journal of virology 2004;78(11):5633-41.
2004: Thomas Muster; Julia Rajtarova; Monika Sachet; Hermann Unger; Reinhard Fleischhacker; Ingrid Romirer; Andreas Grassauer; Angelika Url; Adolfo García-Sastre; Klaus Wolff; Hubert Pehamberger; Michael Bergmann
Interferon resistance promotes oncolysis by influenza virus NS1-deletion mutants.
International journal of cancer. Journal international du cancer 2004;110(1):15-21.
2004: Oliver Ebert; Katsunori Shinozaki; Chryssanthi Kournioti; Man-Seong Park; Adolfo García-Sastre; Savio L C Woo
Syncytia induction enhances the oncolytic potential of vesicular stomatitis virus in virotherapy for cancer.
Cancer research 2004;64(9):3265-70.
2004: Terrence M Tumpey; Adolfo García-Sastre; Jeffery Taubenberger; Peter Palese; David E Swayne; Christopher F Basler
Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3166-71.
2004: Wan-Xiang Li; Hongwei Li; Rui Lu; Feng Li; Monica Dus; Peter Atkinson; Edward W A Brydon; Kyle L Johnson; Adolfo García-Sastre; L Andrew Ball; Peter Palese; Shou-Wei Ding
Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1350-5.
2004: Adolfo García-Sastre
Identification and characterization of viral antagonists of type I interferon in negative-strand RNA viruses.
Current topics in microbiology and immunology 2004;283():249-80.
2003: Yasushi Miyahira; Hisaya Akiba; Masaharu Katae; Kaori Kubota; Seiki Kobayashi; Tsutomu Takeuchi; Adolfo García-Sastre; Yoshinosuke Fukuchi; Ko Okumura; Hideo Yagita; Takashi Aoki
Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6344-8.
2003: Nicola R Donelan; Christopher F Basler; Adolfo García-Sastre
A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice.
Journal of virology 2003;77(24):13257-66.
2003: Jorge L Muñoz-Jordan; Gilma G Sánchez-Burgos; Maudry Laurent-Rolle; Adolfo García-Sastre
Inhibition of interferon signaling by dengue virus.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14333-8.
2003: Gloria González-Aseguinolaza; Yurie Nakaya; Alberto Molano; Edward Dy; Mariano Esteban; Dolores Rodríguez; Juan Ramón Rodríguez; Peter Palese; Adolfo García-Sastre; Ruth S Nussenzweig
Induction of protective immunity against malaria by priming-boosting immunization with recombinant cold-adapted influenza and modified vaccinia Ankara viruses expressing a CD8+-T-cell epitope derived from the circumsporozoite protein of Plasmodium yoelii.
Journal of virology 2003;77(21):11859-66.
2003: Tian-Gui Huang; Oliver Ebert; Katsunori Shinozaki; Adolfo García-Sastre; Savio L C Woo
Oncolysis of hepatic metastasis of colorectal cancer by recombinant vesicular stomatitis virus in immune-competent mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(3):434-40.
2003: Man-Seong Park; Adolfo García-Sastre; Jerome F Cros; Christopher F Basler; Peter Palese
Newcastle disease virus V protein is a determinant of host range restriction.
Journal of virology 2003;77(17):9522-32.
2003: Astrid Flandorfer; Adolfo García-Sastre; Christopher F Basler; Peter Palese
Chimeric influenza A viruses with a functional influenza B virus neuraminidase or hemagglutinin.
Journal of virology 2003;77(17):9116-23.
2003: Oliver Ebert; Katsunori Shinozaki; Tian-Gui Huang; Mikko J Savontaus; Adolfo García-Sastre; Savio L C Woo
Oncolytic vesicular stomatitis virus for treatment of orthotopic hepatocellular carcinoma in immune-competent rats.
Cancer research 2003;63(13):3605-11.
2003: Christopher F Basler; Andrea Mikulasova; Luis Martinez-Sobrido; Jason Paragas; Elke Mühlberger; Mike Bray; Hans-Dieter Klenk; Peter Palese; Adolfo García-Sastre
The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.
Journal of virology 2003;77(14):7945-56.
2003: Clay L Efferson; Jeanne H Schickli; Byung K Ko; Kouichiro Kawano; Sara Mouzi; Peter Palese; Adolfo García-Sastre; Constantin G Ioannides
Activation of tumor antigen-specific cytotoxic T lymphocytes (CTLs) by human dendritic cells infected with an attenuated influenza A virus expressing a CTL epitope derived from the HER-2/neu proto-oncogene.
Journal of virology 2003;77(13):7411-24.
2003: M Magdalena Gherardi; José Luis Nájera; Eva Pérez-Jiménez; Susana Guerra; Adolfo García-Sastre; Mariano Esteban
Prime-boost immunization schedules based on influenza virus and vaccinia virus vectors potentiate cellular immune responses against human immunodeficiency virus Env protein systemically and in the genitorectal draining lymph nodes.
Journal of virology 2003;77(12):7048-57.
2003: Yurie Nakaya; Hongyong Zheng; Adolfo García-Sastre
Enhanced cellular immune responses to SIV Gag by immunization with influenza and vaccinia virus recombinants.
Vaccine 2003;21(17-18):2097-106.
2003: Maite Huarte; Ana M Falcón; Yuri Nakaya; Juan Ortín; Adolfo García-Sastre; Amelia Nieto
Threonine 157 of influenza virus PA polymerase subunit modulates RNA replication in infectious viruses.
Journal of virology 2003;77(10):6007-13.
2003: Carolina B López; Adolfo García-Sastre; Bryan R G Williams; Thomas M Moran
Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA viruses.
The Journal of infectious diseases 2003;187(7):1126-36.
2003: Svetlana V Bourmakina; Adolfo García-Sastre
Reverse genetics studies on the filamentous morphology of influenza A virus.
The Journal of general virology 2003;84(Pt 3):517-27.
2003: David A Chesler; Jorge Luis Muñoz-Jordán; Nicola Donelan; Adolfo García-Sastre; Carol Shoshkes Reiss
PKR is not required for interferon-gamma inhibition of VSV replication in neurons.
Viral immunology 2003;16(1):87-96.
2003: Man-Seong Park; Megan L Shaw; Jorge Muñoz-Jordan; Jerome F Cros; Takaaki Nakaya; Nicole Bouvier; Peter Palese; Adolfo García-Sastre; Christopher F Basler
Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins.
Journal of virology 2003;77(2):1501-11.
2002: Xiuyan Wang; Christopher F Basler; Bryan R G Williams; Robert H Silverman; Peter Palese; Adolfo García-Sastre
Functional replacement of the carboxy-terminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains.
Journal of virology 2002;76(24):12951-62.
2002: Stephan Ludwig; Xiuyan Wang; Christina Ehrhardt; Hongyong Zheng; Nicola R Donelan; Oliver Planz; Stephan Pleschka; Adolfo García-Sastre; Gudrun Heins; Thorsten Wolff
The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors.
Journal of virology 2002;76(21):11166-71.
2002: Terrence M Tumpey; Adolfo García-Sastre; Andrea Mikulasova; Jeffery Taubenberger; David E Swayne; Peter Palese; Christopher F Basler
Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13849-54.
2002: Peter Palese; Christopher F Basler; Adolfo García-Sastre
The makings of a killer.
Nature medicine 2002;8(9):927-8.
2002: Gary K Geiss; Mirella Salvatore; Terrence M Tumpey; Victoria S Carter; Xiuyan Wang; Christopher F Basler; Jeffery Taubenberger; Roger Bumgarner; Peter Palese; Michael G Katze; Adolfo García-Sastre
Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10736-41.
2002: jon yewdell; Adolfo García-Sastre
Influenza virus still surprises.
Current opinion in microbiology 2002;5(4):414-8.
2002: Christopher F Basler; Adolfo García-Sastre
Viruses and the type I interferon antiviral system: induction and evasion.
International reviews of immunology 2002;21(4-5):305-37.
2002: Peter Palese; Adolfo García-Sastre
Influenza vaccines: present and future.
The Journal of clinical investigation 2002;110(1):9-13.
2002: Peter Palese; Adolfo García-Sastre
New directions in vaccine research.
The Journal of clinical investigation 2002;109(12):1517-8.
2002: Adolfo García-Sastre
Mechanisms of inhibition of the host interferon alpha/beta-mediated antiviral responses by viruses.
Microbes and infection / Institut Pasteur 2002;4(6):647-55.
2002: Rosalia Mora; Enrique Rodriguez-Boulan; Peter Palese; Adolfo García-Sastre
Apical budding of a recombinant influenza A virus expressing a hemagglutinin protein with a basolateral localization signal.
Journal of virology 2002;76(7):3544-53.
2002: Mirella Salvatore; Christopher F Basler; Jean-Patrick Parisien; Curt M Horvath; Svetlana V Bourmakina; Hongyong Zheng; Thomas Muster; Peter Palese; Adolfo García-Sastre
Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis.
Journal of virology 2002;76(3):1206-12.
2001: Jeanne H Schickli; A Flandorfer; Takaaki Nakaya; Luis Martinez-Sobrido; Adolfo García-Sastre; Peter Palese
Plasmid-only rescue of influenza A virus vaccine candidates.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1416):1965-73.
2001: Takaaki Nakaya; Jerome F Cros; Man-Seong Park; Yurie Nakaya; Hongyong Zheng; Ana Sagrera; Enrique Villar; Adolfo García-Sastre; Peter Palese
Recombinant Newcastle disease virus as a vaccine vector.
Journal of virology 2001;75(23):11868-73.
2001: Michael Bergmann; Ingrid Romirer; Monika Sachet; R Fleischhacker; Adolfo García-Sastre; Peter Palese; Klaus Wolff; Hubert Pehamberger; Raimund Jakesz; Thomas Muster
A genetically engineered influenza A virus with ras-dependent oncolytic properties.
Cancer research 2001;61(22):8188-93.
2001: Jason Paragas; J Talon; RE O'Neill; D K Anderson; Adolfo García-Sastre; Peter Palese
Influenza B and C virus NEP (NS2) proteins possess nuclear export activities.
Journal of virology 2001;75(16):7375-83.
2001: David E Levy; Adolfo García-Sastre
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion.
Cytokine & growth factor reviews 2001;12(2-3):143-56.
2001: Ana Sagrera; César Cobaleda; José Manuel González de Buitrago; Adolfo García-Sastre; Enrique Villar
Membrane glycoproteins of Newcastle disease virus: nucleotide sequence of the hemagglutinin-neuraminidase cloned gene and structure/function relationship of predicted amino acid sequence.
Glycoconjugate journal 2001;18(4):283-9.
2001: E J Smith; Isabelle Marié; Arun Prakash; Adolfo García-Sastre; David E Levy
IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.
The Journal of biological chemistry 2001;276(12):8951-7.
2001: Christopher F Basler; Ann H Reid; JK Dybing; Thomas A Janczewski; Thomas G Fanning; Hongyong Zheng; Mirella Salvatore; Michael L Perdue; David E Swayne; Adolfo García-Sastre; Peter Palese; Jeffery Taubenberger
Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2746-51.
2001: Adolfo García-Sastre
Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses.
Virology 2001;279(2):375-84.
2000: H Zheng; Peter Palese; Adolfo García-Sastre
Antitumor properties of influenza virus vectors.
Cancer research 2000;60(24):6972-6.
2000: Xiuyan Wang; Ming O Li; Hongyong Zheng; Thomas Muster; Peter Palese; A A Beg; Adolfo García-Sastre
Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon.
Journal of virology 2000;74(24):11566-73.
2000: Christopher F Basler; Xiuyan Wang; Elke Mühlberger; Viktor Volchkov; Jason Paragas; Hans-Dieter Klenk; Adolfo García-Sastre; Peter Palese
The Ebola virus VP35 protein functions as a type I IFN antagonist.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12289-94.
2000: J Talon; Curt M Horvath; Rosalind Polley; Christopher F Basler; Thomas Muster; Peter Palese; Adolfo García-Sastre
Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.
Journal of virology 2000;74(17):7989-96.
2000: Joan E Durbin; Ana Fernandez-Sesma; Chien-kuo Lee; TD Rao; Alan B Frey; Thomas M Moran; Stanislav Vukmanovic; Adolfo García-Sastre; David E Levy
Type I IFN modulates innate and specific antiviral immunity.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4220-8.
2000: J Talon; Mirella Salvatore; RE O'Neill; Y Nakaya; Hongyong Zheng; Thomas Muster; Adolfo García-Sastre; Peter Palese
Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4309-14.
2000: Harry E Gilleland; Linda B Gilleland; John Staczek; RN Harty; Adolfo García-Sastre; Peter Palese; Frank R Brennan; W D O Hamilton; Mohammed Bendahmane; Roger N Beachy
Chimeric animal and plant viruses expressing epitopes of outer membrane protein F as a combined vaccine against Pseudomonas aeruginosa lung infection.
FEMS immunology and medical microbiology 2000;27(4):291-7.
2000: A Solorzano; Hongyong Zheng; Ervin Fodor; George G Brownlee; Peter Palese; Adolfo García-Sastre
Reduced levels of neuraminidase of influenza A viruses correlate with attenuated phenotypes in mice.
The Journal of general virology 2000;81(Pt 3):737-42.
1999: Ervin Fodor; L Devenish; Othmar G Engelhardt; Peter Palese; George G Brownlee; Adolfo García-Sastre
Rescue of influenza A virus from recombinant DNA.
Journal of virology 1999;73(11):9679-82.
1999: Christopher F Basler; Adolfo García-Sastre; Peter Palese
Mutation of neuraminidase cysteine residues yields temperature-sensitive influenza viruses.
Journal of virology 1999;73(10):8095-103.
1999: Hongyong Zheng; H A Lee; Peter Palese; Adolfo García-Sastre
Influenza A virus RNA polymerase has the ability to stutter at the polyadenylation site of a viral RNA template during RNA replication.
Journal of virology 1999;73(6):5240-3.
1999: Rosa M Gonzalo; Dolores Rodríguez; Adolfo García-Sastre; Juan Ramón Rodríguez; Peter Palese; Mariano Esteban
Enhanced CD8+ T cell response to HIV-1 env by combined immunization with influenza and vaccinia virus recombinants.
Vaccine 1999;17(7-8):887-92.
1998: Adolfo García-Sastre; Andrej Egorov; D Matassov; S Brandt; David E Levy; Joan E Durbin; Peter Palese; Thomas Muster
Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems.
Virology 1998;252(2):324-30.
1998: Adolfo García-Sastre; Russell K Durbin; Hongyong Zheng; Peter Palese; Rachel Gertner; David E Levy; Joan E Durbin
The role of interferon in influenza virus tissue tropism.
Journal of virology 1998;72(11):8550-8.
1998: John Staczek; Harry E Gilleland; Linda B Gilleland; RN Harty; Adolfo García-Sastre; Othmar G Engelhardt; Peter Palese
A chimeric influenza virus expressing an epitope of outer membrane protein F of Pseudomonas aeruginosa affords protection against challenge with P. aeruginosa in a murine model of chronic pulmonary infection.
Infection and immunity 1998;66(8):3990-4.
1998: Ervin Fodor; Peter Palese; George G Brownlee; Adolfo García-Sastre
Attenuation of influenza A virus mRNA levels by promoter mutations.
Journal of virology 1998;72(8):6283-90.
1998: Adolfo García-Sastre
Negative-strand RNA viruses: applications to biotechnology.
Trends in biotechnology 1998;16(5):230-5.
1998: Y Miyahira; Adolfo García-Sastre; D Rodriguez; JR Rodriguez; K Murata; Moriya Tsuji; Peter Palese; M Esteban; Fidel Zavala; Ruth S Nussenzweig
Recombinant viruses expressing a human malaria antigen can elicit potentially protective immune CD8+ responses in mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3954-9.
1998: Adrian Bot; Simona Bot; Adolfo García-Sastre; Constantin A Bona
Protective cellular immunity against influenza virus induced by plasmid inoculation of newborn mice.
Developmental immunology 1998;5(3):197-210.
1997: Peter Palese; Fidel Zavala; Thomas Muster; Ruth S Nussenzweig; Adolfo García-Sastre
Development of novel influenza virus vaccines and vectors.
The Journal of infectious diseases 1997;176 Suppl 1():S45-9.
1996: Peter Palese; Hongyong Zheng; Othmar G Engelhardt; S Pleschka; Adolfo García-Sastre
Negative-strand RNA viruses: genetic engineering and applications.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11354-8.
1996: S Pleschka; R Jaskunas; Othmar G Engelhardt; T Zürcher; Peter Palese; Adolfo García-Sastre
A plasmid-based reverse genetics system for influenza A virus.
Journal of virology 1996;70(6):4188-92.
1996: Hongyong Zheng; Peter Palese; Adolfo García-Sastre
Nonconserved nucleotides at the 3' and 5' ends of an influenza A virus RNA play an important role in viral RNA replication.
Virology 1996;217(1):242-51.
1995: Adolfo García-Sastre; Peter Palese
Influenza virus vectors.
Biologicals : journal of the International Association of Biological Standardization 1995;23(2):171-8.
1995: Adolfo García-Sastre; Peter Palese
The cytoplasmic tail of the neuraminidase protein of influenza A virus does not play an important role in the packaging of this protein into viral envelopes.
Virus research 1995;37(1):37-47.
1994: Adolfo García-Sastre; Thomas Muster; Wendy S Barclay; N Percy; Peter Palese
Use of a mammalian internal ribosomal entry site element for expression of a foreign protein by a transfectant influenza virus.
Journal of virology 1994;68(10):6254-61.
1994: N Percy; Wendy S Barclay; Adolfo García-Sastre; Peter Palese
Expression of a foreign protein by influenza A virus.
Journal of virology 1994;68(7):4486-92.
1994: Adolfo García-Sastre; N Percy; Wendy S Barclay; Peter Palese
Introduction of foreign sequences into the genome of influenza A virus.
Developments in biological standardization 1994;82():237-46.
1993: Adolfo García-Sastre; Peter Palese
Genetic manipulation of negative-strand RNA virus genomes.
Annual review of microbiology 1993;47():765-90.
1992: M Bergmann; Adolfo García-Sastre; Peter Palese
Transfection-mediated recombination of influenza A virus.
Journal of virology 1992;66(12):7576-80.