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Christopher Garcia

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TOP 3
Xiaomeng M Yu; K Christopher Garcia; Itai Gutman; Tal Iram; Liqun Luo; Timothy J Mosca; Engin Ozkan; Oren Schuldiner
Plum, an Immunoglobulin Superfamily Protein, Regulates Axon Pruning by Facilitating TGF-β Signaling.
Aaron M Ring; Rosanne Spolski; Gregory R Bowman; Dan Feng; Warren J Leonard; Peng Li; Jian-Xin Lin; Suman Mitra; Ignacio Moraga; Engin Ozkan; Vijay S Pande; Mathias Rickert; K Christopher Garcia
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Michael E Birnbaum; Shen Dong; K Christopher Garcia
Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function.

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All Publications

2013: Xiaomeng M Yu; K Christopher Garcia; Itai Gutman; Tal Iram; Liqun Luo; Timothy J Mosca; Engin Ozkan; Oren Schuldiner
Plum, an Immunoglobulin Superfamily Protein, Regulates Axon Pruning by Facilitating TGF-β Signaling.
Neuron 2013;78(3):456-68.
2012: Aaron M Ring; Rosanne Spolski; Gregory R Bowman; Dan Feng; Warren J Leonard; Peng Li; Jian-Xin Lin; Suman Mitra; Ignacio Moraga; Engin Ozkan; Vijay S Pande; Mathias Rickert; K Christopher Garcia
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Nature immunology 2012;13(12):1187-95.
2012: Michael E Birnbaum; Shen Dong; K Christopher Garcia
Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function.
Immunological reviews 2012;250(1):82-101.
2012: K Christopher Garcia
Insights into immune structure, recognition, and signaling.
Immunological reviews 2012;250(1):5-9.
2012: K Christopher Garcia
Reconciling views on T cell receptor germline bias for MHC.
Trends in immunology 2012;33(9):429-36.
2012: J Fernando Bazan; Claudia Y Janda; K Christopher Garcia
Structural architecture and functional evolution of Wnts.
Developmental cell 2012;23(2):227-32.
2012: Claudia Y Janda; Aron M Levin; Christoph Thomas; Deepa Waghray; K Christopher Garcia
Structural basis of Wnt recognition by Frizzled.
Science (New York, N.Y.) 2012;337(6090):59-64.
2012: K Christopher Garcia; John W Kappler; Jarrett J Adams; Michael E Birnbaum; Laurent Gapin; James P Scott-Browne; Philippa Marrack
A closer look at TCR germline recognition.
Immunity 2012;36(6):887-8; author reply 889-90.
2012: Aron M Levin; Jack T Lin; Ignacio Moraga; Paul Novick; Vijay S Pande; Miro E Raeber; Aaron M Ring; Leon Su; Darren L Bates; Gregory R Bowman; Onur Boyman; C Garrison Fathman; Carsten Krieg; K Christopher Garcia
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.
Nature 2012;484(7395):529-33.
2012: Christoph Thomas; J Fernando Bazan; K Christopher Garcia
Structure of the activating IL-1 receptor signaling complex.
Nature structural & molecular biology 2012;19(4):455-7.
2011: Christoph Thomas; Angelica Trejo; Susan E Vleck; Ganit Yarden; Jeffrey S Glenn; Peter O Krutzik; Choongho Lee; Doron Levin; Ignacio Moraga; Garry P Nolan; Jacob Piehler; Yulia Podoplelova; Gideon Schreiber; K Christopher Garcia
Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell 2011;146(4):621-32.
2011: Evan W Newell; Lauren K Ely; Andrew C Kruse; Philip A Reay; Stephanie N Rodriguez; Aaron E Lin; Michael S Kuhns; K Christopher Garcia; Mark M Davis
Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5823-32.
2011: Aimee Shen; Patrick J Lupardus; Malte M Gersch; Aaron W Puri; Victoria E Albrow; K Christopher Garcia; Matthew Bogyo
Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.
Nature structural & molecular biology 2011;18(3):364-71.
2011: Michael Gleimer; Angela R Wahl; Heather D Hickman; Laurent Abi-Rached; Paul J Norman; Lisbeth A Guethlein; John Hammond; Monia Draghi; Erin J Adams; Sean Juo; Roxana Jalili; Baback Gharizadeh; Mostafa Ronaghi; K Christopher Garcia; William H Hildebrand; Peter Parham
Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1575-88.
2011: Patrick J Lupardus; georgios skiniotis; Amanda J Rice; Christoph Thomas; Suzanne Fischer; Thomas Walz; K Christopher Garcia
Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex.
Structure (London, England : 1993) 2011;19(1):45-55.
2010: Aaron W Puri; Patrick J Lupardus; Edgar Deu; Victoria E Albrow; K Christopher Garcia; Matthew Bogyo; Aimee Shen
Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB.
Chemistry & biology 2010;17(11):1201-11.
2010: Heli Liu; Z Sean Juo; Ann Hye-Ryong Shim; Pamela J Focia; Xiaoyan Chen; K Christopher Garcia; Xiaolin He
Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.
Cell 2010;142(5):749-61.
2010: Jeremy Juang; Peter J R Ebert; Dan Feng; K Christopher Garcia; Michelle Krogsgaard; Mark M Davis
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.
The Journal of experimental medicine 2010;207(6):1223-34.
2010: Patrick J Lupardus; Michael E Birnbaum; K Christopher Garcia
Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2.
Structure (London, England : 1993) 2010;18(3):332-42.
2010: Dan Feng; Taeho Kim; Engin Ozkan; Matthew Light; Risa Torkin; Kenneth K Teng; Barbara L Hempstead; K Christopher Garcia
Molecular and structural insight into proNGF engagement of p75NTR and sortilin.
Journal of molecular biology 2010;396(4):967-84.
2009: Elise Landais; Pablo A Romagnoli; Adam L Corper; John Shires; John D Altman; Ian A Wilson; K Christopher Garcia; Luc Teyton
New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7949-57.
2009: Lauren K Ely; Suzanne Fischer; K Christopher Garcia
Structural basis of receptor sharing by interleukin 17 cytokines.
Nature immunology 2009;10(12):1245-51.
2009: Natalie A Bowerman; Leremy Colf; K Christopher Garcia; David M Kranz
Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides.
The Journal of biological chemistry 2009;284(47):32551-61.
2009: Cagla Eroglu; Nicola J Allen; Michael W Susman; Nancy A O'Rourke; Chan Young Park; Engin Ozkan; Chandrani Chakraborty; Sara B Mulinyawe; Douglas S Annis; Andrew D Huberman; Eric M Green; Jack Lawler; Ricardo E Dolmetsch; K Christopher Garcia; Stephen J Smith; Z David Luo; Arnon Rosenthal; Deane F Mosher; Ben A Barres
Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.
Cell 2009;139(2):380-92.
2009: Aimee Shen; Patrick J Lupardus; Victoria E Albrow; Andrew Guzzetta; James C Powers; K Christopher Garcia; Matthew Bogyo
Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.
Nature chemical biology 2009;5(7):469-78.
2009: Jimin Pei; Patrick J Lupardus; K Christopher Garcia; Nick V Grishin
CPDadh: a new peptidase family homologous to the cysteine protease domain in bacterial MARTX toxins.
Protein science : a publication of the Protein Society 2009;18(4):856-62.
2009: Chan Young Park; Paul J Hoover; Franklin M Mullins; Priti Bachhawat; Elizabeth D Covington; Stefan Raunser; Thomas Walz; K Christopher Garcia; Ricardo E Dolmetsch; Richard S Lewis
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.
Cell 2009;136(5):876-90.
2009: K Christopher Garcia; Jarrett J Adams; Dan Feng; Lauren K Ely
The molecular basis of TCR germline bias for MHC is surprisingly simple.
Nature immunology 2009;10(2):143-7.
2009: Aimee Shen; Patrick J Lupardus; Montse Morell; Elizabeth L Ponder; A Masoud Sadaghiani; K Christopher Garcia; Matthew Bogyo
Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag.
PloS one 2009;4(12):e8119.
2009: Xinquan Wang; Patrick Lupardus; Sherry L. LaPorte; K Christopher Garcia
Structural biology of shared cytokine receptors.
Annual review of immunology 2009;27():29-60.
2008: Abhiram Dukkipati; Hyun Ho Park; Deepa Waghray; Suzanne Fischer; K Christopher Garcia
BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies.
Protein expression and purification 2008;62(2):160-70.
2008: Lindsay L Jones; Leremy Colf; Alexander J Bankovich; Jennifer D Stone; Yi-Gui Gao; Choi Mui Chan; Raven H Huang; K Christopher Garcia; David M Kranz
Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors.
Biochemistry 2008;47(47):12398-408.
2008: Lindsay L Jones; Leremy Colf; Jennifer D Stone; K Christopher Garcia; David M Kranz
Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6255-64.
2008: Patrick J Lupardus; K Christopher Garcia
The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.
Journal of molecular biology 2008;382(4):931-41.
2008: Patrick J Lupardus; Aimee Shen; Matthew Bogyo; K Christopher Garcia
Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain.
Science (New York, N.Y.) 2008;322(5899):265-8.
2008: georgios skiniotis; Patrick J Lupardus; Monika Martick; Thomas Walz; K Christopher Garcia
Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.
Molecular cell 2008;31(5):737-48.
2008: Sherry L. LaPorte; Z Sean Juo; Jana Vaclavikova; Leremy Colf; Xiulan Qi; Nicola M Heller; Achsah D Keegan; K Christopher Garcia
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.
Cell 2008;132(2):259-72.
2007: Leremy Colf; Z Sean Juo; K Christopher Garcia
Structure of the measles virus hemagglutinin.
Nature structural & molecular biology 2007;14(12):1227-8.
2007: Cornelia H Rinderknecht; Michael P Belmares; Tatiana L W Catanzarite; Alexander J Bankovich; Tyson H Holmes; K Christopher Garcia; Navreet K Nanda; Robert Busch; Susan Kovats; Elizabeth D Mellins
Posttranslational regulation of I-Ed by affinity for CLIP.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5907-15.
2007: Dan Feng; Christopher J Bond; Lauren K Ely; Jennifer Maynard; K Christopher Garcia
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
Nature immunology 2007;8(9):975-83.
2007: Nicole A Hanick; Mathias Rickert; test testing; Alexander J Bankovich; Jennifer Cochran; David M Kim; Charles D Surh; K Christopher Garcia
Elucidation of the interleukin-15 binding site on its alpha receptor by NMR.
Biochemistry 2007;46(33):9453-61.
2007: test testing; Alexander J Bankovich; Corey W Liu; Leremy Colf; Lindsay L Jones; David M Kranz; Joseph D Puglisi; K Christopher Garcia
Solution mapping of T cell receptor docking footprints on peptide-MHC.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13080-5.
2007: Kai W Wucherpfennig; Paul M Allen; Franco Celada; Irun R Cohen; Rob De Boer; K Christopher Garcia; Byron Goldstein; Ralph Greenspan; David A Hafler; Philip Hodgkin; Erik S Huseby; David C Krakauer; David Nemazee; Alan S Perelson; Clemencia Pinilla; Roland K Strong; Eli E Sercarz
Polyspecificity of T cell and B cell receptor recognition.
Seminars in immunology 2007;19(4):216-24.
2007: Erin J Adams; Z Sean Juo; Rayna Takaki Venook; Martin J Boulanger; Hisashi Arase; Lewis L Lanier; K Christopher Garcia
Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):10128-33.
2007: Alexander J Bankovich; Stefan Raunser; Z Sean Juo; Thomas Walz; Mark M Davis; K Christopher Garcia
Structural insight into pre-B cell receptor function.
Science (New York, N.Y.) 2007;316(5822):291-4.
2007: Leremy Colf; Alexander J Bankovich; Nicole A Hanick; Natalie A Bowerman; Lindsay L Jones; David M Kranz; K Christopher Garcia
How a single T cell receptor recognizes both self and foreign MHC.
Cell 2007;129(1):135-46.
2007: Takaki Komiyama; Lora B Sweeney; Oren Schuldiner; K Christopher Garcia; Liqun Luo
Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons.
Cell 2007;128(2):399-410.
2007: Tom S Wehrman; Xiaolin He; Bill Raab; Abhiram Dukipatti; Helen Blau; K Christopher Garcia
Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.
Neuron 2007;53(1):25-38.
2006: Abhiram Dukkipati; Jana Vaclavikova; Deepa Waghray; K Christopher Garcia
In vitro reconstitution and preparative purification of complexes between the chemokine receptor CXCR4 and its ligands SDF-1alpha, gp120-CD4 and AMD3100.
Protein expression and purification 2006;50(2):203-14.
2006: Lindsay L Jones; Susan E Brophy; Alexander J Bankovich; Leremy Colf; Nicole A Hanick; K Christopher Garcia; David M Kranz
Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld.
The Journal of biological chemistry 2006;281(35):25734-44.
2006: Xiao-lin He; Abhiram Dukkipati; K Christopher Garcia
Structural determinants of natriuretic peptide receptor specificity and degeneracy.
Journal of molecular biology 2006;361(4):698-714.
2006: Xinquan Wang; Robert H Baloh; Jeffrey Milbrandt; K Christopher Garcia
Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.
Structure (London, England : 1993) 2006;14(6):1083-92.
2006: Michael S Kuhns; Mark M Davis; K Christopher Garcia
Deconstructing the form and function of the TCR/CD3 complex.
Immunity 2006;24(2):133-9.
2005: Jennifer Maynard; Erin J Adams; Michelle Krogsgaard; Karin Petersson; Corey W Liu; K Christopher Garcia
High-level bacterial secretion of single-chain alphabeta T-cell receptors.
Journal of immunological methods 2005;306(1-2):51-67.
2005: Xinquan Wang; Mathias Rickert; K Christopher Garcia
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.
Science (New York, N.Y.) 2005;310(5751):1159-63.
2005: K Christopher Garcia; Erin J Adams
How the T cell receptor sees antigen--a structural view.
Cell 2005;122(3):333-6.
2005: Mathias Rickert; Xinquan Wang; Martin J Boulanger; Natalia Goriatcheva; K Christopher Garcia
The structure of interleukin-2 complexed with its alpha receptor.
Science (New York, N.Y.) 2005;308(5727):1477-80.
2005: Xiao-lin He; Abhiram Dukkipati; Xinquan Wang; K Christopher Garcia
A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C.
Peptides 2005;26(6):1035-43.
2005: georgios skiniotis; Martin J Boulanger; K Christopher Garcia; Thomas Walz
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor.
Nature structural & molecular biology 2005;12(6):545-51.
2005: Sunny Shin; Ramy El-Diwany; Steven Schaffert; Erin J Adams; K Christopher Garcia; Pablo Pereira; Yueh-hsiu Chien
Antigen recognition determinants of gammadelta T cell receptors.
Science (New York, N.Y.) 2005;308(5719):252-5.
2005: Erin J Adams; Yueh-hsiu Chien; K Christopher Garcia
Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
Science (New York, N.Y.) 2005;308(5719):227-31.
2005: Jong Bae Park; Glenn Yiu; Shinjiro Kaneko; Jing Wang; Jufang Chang; Xiao-lin He; K Christopher Garcia; Zhigang He
A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors.
Neuron 2005;45(3):345-51.
2005: Binhai Zheng; Jasvinder Atwal; Carole Ho; Lauren Case; Xiao-lin He; K Christopher Garcia; Oswald Steward; Marc Tessier-Lavigne
Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(4):1205-10.
2005: Jennifer Maynard; Karin Petersson; Dianne H Wilson; Erin J Adams; Sylvie E Blondelle; Martin J Boulanger; Darcy B Wilson; K Christopher Garcia
Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.
Immunity 2005;22(1):81-92.
2004: Pavel Strop; Alexander J Bankovich; Kirk Hansen; K Christopher Garcia; Axel T Brunger
Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family.
Journal of molecular biology 2004;343(4):1055-65.
2004: Mathias Rickert; Martin J Boulanger; Natalia Goriatcheva; K Christopher Garcia
Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors.
Journal of molecular biology 2004;339(5):1115-28.
2004: Xiao-lin He; K Christopher Garcia
Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.
Science (New York, N.Y.) 2004;304(5672):870-5.
2004: Darcy B Wilson; Dianne H Wilson; Kim Schroder; Clemencia Pinilla; Sylvie E Blondelle; Richard A Houghten; K Christopher Garcia
Specificity and degeneracy of T cells.
Molecular immunology 2004;40(14-15):1047-55.
2004: Alexander J Bankovich; Andrew T Girvin; Achim K Moesta; K Christopher Garcia
Peptide register shifting within the MHC groove: theory becomes reality.
Molecular immunology 2004;40(14-15):1033-9.
2004: Martin J Boulanger; Dar-Chone Chow; Elena E Brevnova; Monika Martick; GORDON SANDFORD; John Nicholas; K Christopher Garcia
Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6.
Journal of molecular biology 2004;335(2):641-54.
2004: Martin J Boulanger; K Christopher Garcia
Shared cytokine signaling receptors: structural insights from the gp130 system.
Advances in protein chemistry 2004;68():107-46.
2003: Michelle Krogsgaard; Nelida Prado; Erin J Adams; Xiao-lin He; Dar-Chone Chow; Darcy B Wilson; K Christopher Garcia; Mark M Davis
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.
Molecular cell 2003;12(6):1367-78.
2003: Martin J Boulanger; Alexander J Bankovich; Tanja Kortemme; David Baker; K Christopher Garcia
Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130.
Molecular cell 2003;12(3):577-89.
2003: Martin J Boulanger; Dar-Chone Chow; Elena E Brevnova; K Christopher Garcia
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.
Science (New York, N.Y.) 2003;300(5628):2101-4.
2003: Xiao-lin He; J. Fernando Bazan; Gerry McDermott; Jong Bae Park; Kevin Wang; Marc Tessier-Lavigne; Zhigang He; K Christopher Garcia
Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition.
Neuron 2003;38(2):177-85.
2003: Alexander J Bankovich; K Christopher Garcia
Not just any T cell receptor will do.
Immunity 2003;18(1):7-11.
2002: Dar-Chone Chow; Lena Brevnova; Xiao-lin He; Monika Martick; Alexander J Bankovich; K Christopher Garcia
A structural template for gp130-cytokine signaling assemblies.
Biochimica et biophysica acta 2002;1592(3):225-35.
2002: Erin J Adams; K Christopher Garcia
A T cell receptor goes public.
Structure (London, England : 1993) 2002;10(11):1468-9.
2002: Lawren C Wu; Delphine S Tuot; Daniel S Lyons; K Christopher Garcia; Mark M Davis
Two-step binding mechanism for T-cell receptor recognition of peptide MHC.
Nature 2002;418(6897):552-6.
2002: Stéphane Sidobre; Olga V Naidenko; Bee-Cheng Sim; Nicholas R J Gascoigne; K Christopher Garcia; Mitchell Kronenberg
The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1340-8.
2002: Xiao-lin He; Michael E Grigg; John C Boothroyd; K Christopher Garcia
Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily.
Nature structural biology 2002;9(8):606-11.
2002: Xiao-lin He; Caius Radu; John Sidney; Alessandro Sette; E Sally Ward; K Christopher Garcia
Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au.
Immunity 2002;17(1):83-94.
2002: John G Luz; Mingdong Huang; K Christopher Garcia; Markus G Rudolph; Vasso Apostolopoulos; Luc Teyton; Ian A Wilson
Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.
The Journal of experimental medicine 2002;195(9):1175-86.
2002: Robert Busch; Achal Pashine; K Christopher Garcia; Elizabeth D Mellins
Stabilization of soluble, low-affinity HLA-DM/HLA-DR1 complexes by leucine zippers.
Journal of immunological methods 2002;263(1-2):111-21.
2001: X He; Piotr Tabaczewski; J Ho; Iwona Stroynowski; K Christopher Garcia
Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation.
Structure (London, England : 1993) 2001;9(12):1213-24.
2001: Pedro J Ruiz; Jason DeVoss; L V Nguyen; Paulo Fontoura; DL Hirschberg; Dennis J Mitchell; K Christopher Garcia; Lawrence Steinman
Immunomodulation of experimental autoimmune encephalomyelitis with ordered peptides based on MHC-TCR binding motifs.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2688-93.
2001: Monika Martick; K Christopher Garcia
Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone.
Science (New York, N.Y.) 2001;293(5535):1657-62.
2001: Dar Chow; J Ho; T L Nguyen Pham; S Rose-John; K Christopher Garcia
In vitro reconstitution of recognition and activation complexes between interleukin-6 and gp130.
Biochemistry 2001;40(25):7593-603.
2001: Dar Chow; X He ; A L Snow; S Rose-John; K Christopher Garcia
Structure of an extracellular gp130 cytokine receptor signaling complex.
Science (New York, N.Y.) 2001;291(5511):2150-5.
2000: Adam L Corper; Thomas Stratmann; Vasso Apostolopoulos; C A Scott; K Christopher Garcia; Angray S Kang; Ian A Wilson; Luc Teyton
A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.
Science (New York, N.Y.) 2000;288(5465):505-11.
2000: M Degano; K Christopher Garcia; Vasso Apostolopoulos; Markus G Rudolph; Luc Teyton; Ian A Wilson
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.
Immunity 2000;12(3):251-61.
1999: K Christopher Garcia
Molecular interactions between extracellular components of the T-cell receptor signaling complex.
Immunological reviews 1999;172():73-85.
1999: K Christopher Garcia; M Degano; Jeffrey A Speir; Ian A Wilson
Emerging principles for T cell receptor recognition of antigen in cellular immunity.
Reviews in immunogenetics 1999;1(1):75-90.
1999: K Christopher Garcia; Luc Teyton; Ian A Wilson
Structural basis of T cell recognition.
Annual review of immunology 1999;17():369-97.
1998: Z Cai; AB Brunmark; AT Luxembourg; K Christopher Garcia; M Degano; Luc Teyton; I Wilson; PA Peterson; Jonathan Sprent; MR Jackson
Probing the activation requirements for naive CD8+ T cells with Drosophila cell transfectants as antigen presenting cells.
Immunological reviews 1998;165():249-65.
1998: K Christopher Garcia; Luc Teyton
T-cell receptor peptide-MHC interactions: biological lessons from structural studies.
Current opinion in biotechnology 1998;9(4):338-43.
1998: Jeffrey A Speir; K Christopher Garcia; AB Brunmark; M Degano; PA Peterson; Luc Teyton; Ian A Wilson
Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes.
Immunity 1998;8(5):553-62.
1998: T C Manning; C J Schlueter; T C Brodnicki; EA Parke; Jeffrey A Speir; K Christopher Garcia; Luc Teyton; Ian A Wilson; David M Kranz
Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition.
Immunity 1998;8(4):413-25.
1998: K Christopher Garcia; M Degano; Larry R Pease; Mingdong Huang; PA Peterson; Luc Teyton; Ian A Wilson
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.
Science (New York, N.Y.) 1998;279(5354):1166-72.
1998: CA Scott; K Christopher Garcia; Enrico STURA; PA Peterson; Ian A Wilson; Luc Teyton
Engineering protein for X-ray crystallography: the murine Major Histocompatibility Complex class II molecule I-Ad.
Protein science : a publication of the Protein Society 1998;7(2):413-8.
1997: K Christopher Garcia; Michelle Tallquist; Larry R Pease; AB Brunmark; CA Scott; M Degano; Enrico STURA; PA Peterson; Ian A Wilson; Luc Teyton
Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13838-43.
1997: Ian A Wilson; K Christopher Garcia
T-cell receptor structure and TCR complexes.
Current opinion in structural biology 1997;7(6):839-48.
1996: K Christopher Garcia; C A Scott; AB Brunmark; F R Carbone; PA Peterson; Ian A Wilson; Luc Teyton
CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes.
Nature 1996;384(6609):577-81.
1996: K Christopher Garcia; M Degano; R L Stanfield; AB Brunmark; MR Jackson; PA Peterson; Luc Teyton; Ian A Wilson
An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex.
Science (New York, N.Y.) 1996;274(5285):209-19.
1996: C A Scott; K Christopher Garcia; F R Carbone; Ian A Wilson; Luc Teyton
Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules.
The Journal of experimental medicine 1996;183(5):2087-95.