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Maria Garcia

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Chemicals & Drugs

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Ion Channel Gating

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Scott B Hoyt; Nina Jochnowitz; Gregory J Kaczorowski; Bindhu V Karanam; Xiaohua Li; Clare London; Kathryn A Lyons; Erin McGowan; Birgit T Priest; McHardy M Smith; Brande S Thomas-Fowlkes; Vivien A Warren; Catherine Abbadie; John P Felix; Maria L Garcia; Joseph L Duffy
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
Pengcheng P Shao; McHardy M Smith; Shu-Yu Sun; Andrew M Swensen; Deepu J Varughese; Vivien A Warren; Feng Ye; Catherine Abbadie; Randal M Bugianesi; Prasun K Chakravarty; Ge Dai; Maria L Garcia; Mitchell Green; Rodolfo J Haedo; James B Herrington; Nina Jochnowitz; Gregory J Kaczorowski; Xiaohua Li; Kathryn A Lyons; Erin McGowan; Owen B McManus; Shruti Mistry; Joseph L Duffy
Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.
John P Felix; Magdalena Alonso-Galicia; Timothy Bailey; Richard M Brochu; Gregory J Kaczorowski; Laszlo Kiss; Martin G Kohler; Chou J Liu; Alexander Pasternak; Birgit T Priest; Kelli Solly; Haifeng Tang; Maria L Garcia
The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors.

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All Publications

2013: Scott B Hoyt; Nina Jochnowitz; Gregory J Kaczorowski; Bindhu V Karanam; Xiaohua Li; Clare London; Kathryn A Lyons; Erin McGowan; Birgit T Priest; McHardy M Smith; Brande S Thomas-Fowlkes; Vivien A Warren; Catherine Abbadie; John P Felix; Maria L Garcia; Joseph L Duffy
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
Bioorganic & medicinal chemistry letters 2013;23(12):3640-5.
2012: Pengcheng P Shao; McHardy M Smith; Shu-Yu Sun; Andrew M Swensen; Deepu J Varughese; Vivien A Warren; Feng Ye; Catherine Abbadie; Randal M Bugianesi; Prasun K Chakravarty; Ge Dai; Maria L Garcia; Mitchell Green; Rodolfo J Haedo; James B Herrington; Nina Jochnowitz; Gregory J Kaczorowski; Xiaohua Li; Kathryn A Lyons; Erin McGowan; Owen B McManus; Shruti Mistry; Joseph L Duffy
Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.
Journal of medicinal chemistry 2012;55(22):9847-55.
2012: John P Felix; Magdalena Alonso-Galicia; Timothy Bailey; Richard M Brochu; Gregory J Kaczorowski; Laszlo Kiss; Martin G Kohler; Chou J Liu; Alexander Pasternak; Birgit T Priest; Kelli Solly; Haifeng Tang; Maria L Garcia
The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors.
Assay and drug development technologies 2012;10(5):417-31.
2011: James Herrington; Andrew Howard; Qiaolin Deng; Ranjit Desai; Maria L Garcia; Laszlo Kiss; Nina Li; Owen B McManus; Kevin S Ratliff; Kelli Solly; Yusheng Xiong; Yun-Ping Zhou; Gregory J Kaczorowski
Identification of novel and selective Kv2 channel inhibitors.
Molecular pharmacology 2011;80(6):959-64.
2010: william Schmalhofer; Andrew M Swensen; Brande S Thomas; John P Felix; Rodolfo J Haedo; Kelli Solly; Laszlo Kiss; Gregory J Kaczorowski; Maria L Garcia
A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.
Assay and drug development technologies 2010;8(6):714-26.
2009: william Schmalhofer; Kevin S Ratliff; Adam Weinglass; Gregory J Kaczorowski; Maria L Garcia; James Herrington
A KV2.1 gating modifier binding assay suitable for high throughput screening.
Channels (Austin, Tex.) 2009;3(6):437-47.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2009;19(18):5334-8.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Bioorganic & medicinal chemistry letters 2009;19(18):5329-33.
2008: william Schmalhofer; Jeffrey Calhoun; Rachel Burrows; Timothy Bailey; Martin G Kohler; Adam B Weinglass; Gregory J Kaczorowski; Maria L Garcia; Martin Koltzenburg; Birgit T Priest
ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.
Molecular pharmacology 2008;74(5):1476-84.
2008: Adam B Weinglass; Maria L Garcia; Gregory L Kaczorowski
Technologies for transporter drug discovery.
Channels (Austin, Tex.) 2008;2(5):312-21.
2008: Adam B Weinglass; Martin Kohler; Uwe Schulte; Jessica Liu; Emmanuel O Nketiah; Anu Thomas; william Schmalhofer; Brande Williams; Wolfgang Bildl; Daniel R McMasters; Kevin Dai; Lindsey Beers; Margaret E McCann; Gregory J Kaczorowski; Maria L Garcia
Extracellular loop C of NPC1L1 is important for binding to ezetimibe.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11140-5.
2008: Gregory J Kaczorowski; Owen B McManus; Birgit T Priest; Maria L Garcia
Ion channels as drug targets: the next GPCRs.
The Journal of general physiology 2008;131(5):399-405.
2008: Adam B Weinglass; Andrew M Swensen; Jessica Liu; william Schmalhofer; Anu Thomas; Brande Williams; Leila Ross; Kristina Hashizume; Martin Kohler; Gregory J Kaczorowski; Maria L Garcia
A high-capacity membrane potential FRET-based assay for the sodium-coupled glucose co-transporter SGLT1.
Assay and drug development technologies 2008;6(2):255-62.
2008: Adam B Weinglass; Martin G Köhler; Emmanuel O Nketiah; Jessica Liu; william Schmalhofer; Anu Thomas; Brande Williams; Lindsey Beers; Lauren Smith; Mike Hafey; Kelly Bleasby; Joseph Leone; Yui S Tang; Matthew Braun; Feroze Ujjainwalla; Margaret E McCann; Gregory J Kaczorowski; Maria L Garcia
Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake.
Molecular pharmacology 2008;73(4):1072-84.
2008: Scott B Hoyt; Clare London; Matthew J Wyvratt; Michael H Fisher; Doreen E Cashen; John P Felix; Maria L Garcia; Xiaohua Li; Kathryn A Lyons; D Euan MacIntyre; William J Martin; Birgit T Priest; McHardy Smith; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.
Bioorganic & medicinal chemistry letters 2008;18(6):1963-6.
2008: Birgit T Priest; Ian M Bell; Maria L Garcia
Role of hERG potassium channel assays in drug development.
Channels (Austin, Tex.) 2008;2(2):87-93.
2008: Clare London; Scott B Hoyt; William H Parsons; Brande S Williams; Vivien A Warren; Richard A Tschirret-Guth; McHardy Smith; Birgit T Priest; Erin McGowan; William J Martin; Kathryn A Lyons; Xiaohua Li; Bindhu V Karanam; Nina Jochnowitz; Maria L Garcia; John P Felix; Brian Dean; Catherine Abbadie; Gregory J Kaczorowski; Joseph L Duffy
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Bioorganic & medicinal chemistry letters 2008;18(5):1696-701.
2008: Kathleen M Giangiacomo; Jennifer Becker; Christopher Garsky; william Schmalhofer; Maria L Garcia; Theodore J Mullmann
Novel alpha-KTx sites in the BK channel and comparative sequence analysis reveal distinguishing features of the BK and KV channel outer pore.
Cell biochemistry and biophysics 2008;52(1):47-58.
2007: Brande S Williams; John P Felix; Birgit T Priest; Richard Brochu; Kefei Dai; Scott B Hoyt; Clare London; Yui S Tang; Joseph L Duffy; William H Parsons; Gregory J Kaczorowski; Maria L Garcia
Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.
Biochemistry 2007;46(50):14693-703.
2007: Scott B Hoyt; Clare London; Hyun O Ok; Edward Gonzalez; Joseph L Duffy; Catherine Abbadie; Brian Dean; John P Felix; Maria L Garcia; Nina Jochnowitz; Bindhu V Karanam; Xiaohua Li; Kathryn A Lyons; Erin McGowan; D Euan MacIntyre; William J Martin; Birgit T Priest; McHardy Smith; Richard A Tschirret-Guth; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.
Bioorganic & medicinal chemistry letters 2007;17(22):6172-7.
2007: Scott B Hoyt; Clare London; David J. Gorin; Matthew J Wyvratt; Michael H Fisher; Catherine Abbadie; John P Felix; Maria L Garcia; Xiaohua Li; Kathryn A Lyons; Erin McGowan; D Euan MacIntyre; William J Martin; Birgit T Priest; Amy Ritter; McHardy Smith; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.
Bioorganic & medicinal chemistry letters 2007;17(16):4630-4.
2007: Kathleen M Giangiacomo; Jennifer Becker; Christopher Garsky; John P Felix; Birgit T Priest; william Schmalhofer; Maria L Garcia; Theodore J Mullmann
Revealing the molecular determinants of neurotoxin specificity for calcium-activated versus voltage-dependent potassium channels.
Biochemistry 2007;46(18):5358-64.
2006: Birgit T Priest; Gregory J Kaczorowski; Maria L Garcia
Ion channel modulators: new targets and new indications for old targets.
Current opinion in drug discovery & development 2006;9(5):587-94.
2006: John P Felix; Jessica Liu; william Schmalhofer; Timothy Bailey; Maria A Bednarek; Stephanie Kinkel; Adam B Weinglass; Martin Kohler; Gregory J Kaczorowski; Birgit T Priest; Maria L Garcia
Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin.
Biochemistry 2006;45(33):10129-39.
2006: James Herrington; Yun-Ping Zhou; Randal M Bugianesi; Paula M Dulski; Yue Feng; Vivien A Warren; McHardy Smith; Martin G Kohler; Victor M Garsky; Manuel Sanchez; Michael Wagner; Kristin Raphaelli; Priya Banerjee; Chinweze Ahaghotu; Denise Wunderler; Birgit T Priest; John T Mehl; Maria L Garcia; Owen B McManus; Gregory J Kaczorowski; Robert S Slaughter
Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion.
Diabetes 2006;55(4):1034-42.
2006: Dong Ok; Chunshi Li; Catherine Abbadie; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; William J Martin; Birgit T Priest; McHardy Smith; Brande S Williams; Matthew J Wyvratt; William H Parsons
Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.
Bioorganic & medicinal chemistry letters 2006;16(5):1358-61.
2006: Chou J Liu; Birgit T Priest; Randal M Bugianesi; Paula M Dulski; John P Felix; Ivy E Dick; Richard Brochu; Hans-Günther Knaus; Richard E Middleton; Gregory J Kaczorowski; Robert S Slaughter; Maria L Garcia; Martin G Köhler
A high-capacity membrane potential FRET-based assay for NaV1.8 channels.
Assay and drug development technologies 2006;4(1):37-48.
2005: Maria L Garcia; Gregory J Kaczorowski
Potassium channels as targets for therapeutic intervention.
Science's STKE : signal transduction knowledge environment 2005;2005(302):pe46.
2005: william Schmalhofer; Manuel Sanchez; Ge Dai; Ashvin Dewan; Lorena Secades; Markus Hanner; Hans-Günther Knaus; Owen B McManus; Martin Kohler; Gregory J Kaczorowski; Maria L Garcia
Role of the C-terminus of the high-conductance calcium-activated potassium channel in channel structure and function.
Biochemistry 2005;44(30):10135-44.
2005: Bernard Gilquin; Sandrine Braud; Mats A L Eriksson; Benoît Roux; Timothy D Bailey; Birgit T Priest; Maria L Garcia; André Ménez; Sylvaine Gasparini
A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions.
The Journal of biological chemistry 2005;280(29):27093-102.
2005: Jun Liang; Richard Brochu; charles cohen; Ivy E Dick; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; Peter T Meinke; Birgit T Priest; william Schmalhofer; McHardy Smith; Jason W Tarpley; Brande S Williams; William J Martin; William H Parsons
Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(11):2943-7.
2005: Lizhen Yan; James Herrington; Ethan Goldberg; Paula M Dulski; Randal M Bugianesi; Robert S Slaughter; Priya Banerjee; Richard Brochu; Birgit T Priest; Gregory J Kaczorowski; Bernardo Rudy; Maria L Garcia
Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels.
Molecular pharmacology 2005;67(5):1513-21.
2005: Pengcheng P Shao; Dong Ok; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Chunshi Li; Kathryn A Lyons; William J Martin; Peter T Meinke; Birgit T Priest; McHardy Smith; Matthew J Wyvratt; Feng Ye; William H Parsons
Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(7):1901-7.
2005: Jianming Bao; Shouwu Miao; Frank Kayser; Andrew Kotliar; Robert K Baker; George A Doss; John P Felix; Randal M Bugianesi; Robert S Slaughter; Gregory J Kaczorowski; Maria L Garcia; Sookhee N Ha; Laurie A Castonguay; Gloria C Koo; Kashmira Shah; Martin S Springer; Mary Jo Staruch; William H Parsons; Kathleen M Rupprecht
Potent Kv1.3 inhibitors from correolide-modification of the C18 position.
Bioorganic & medicinal chemistry letters 2005;15(2):447-51.
2004: Sandrine Braud; Pascal Belin; Janie Dassa; Liliana Pardo; Gilles Mourier; Antony Caruana; Birgit T Priest; Paula M Dulski; Maria L Garcia; André Ménez; Jean-Claude Boulain; Sylvaine Gasparini
BgK, a disulfide-containing sea anemone toxin blocking K+ channels, can be produced in Escherichia coli cytoplasm as a functional tagged protein.
Protein expression and purification 2004;38(1):69-78.
2004: Birgit T Priest; Maria L Garcia; Richard E Middleton; Richard Brochu; Samantha Clark; Ge Dai; Ivy E Dick; John P Felix; Chou J Liu; Brita S Reiseter; william Schmalhofer; Pengcheng P Shao; Yui S Tang; Margaret Z Chou; Martin G Kohler; McHardy Smith; Vivien A Warren; Brande S Williams; charles cohen; William J Martin; Peter T Meinke; William H Parsons; Keith A Wafford; Gregory J Kaczorowski
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.
Biochemistry 2004;43(30):9866-76.
2004: John P Felix; Brande S Williams; Birgit T Priest; Richard Brochu; Ivy E Dick; Vivien A Warren; Lizhen Yan; Robert S Slaughter; Gregory J Kaczorowski; McHardy Smith; Maria L Garcia
Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.
Assay and drug development technologies 2004;2(3):260-8.
2003: Richard E Middleton; Manuel Sanchez; Ana-Rosa Linde; Randal M Bugianesi; Ge Dai; John P Felix; Sam L Koprak; Mary Jo Staruch; Marc Bruguera; Rachael Cox; Amrita Ghosh; Jeremy Hwang; Simmonette Jones; Martin Kohler; Robert S Slaughter; Owen B McManus; Gregory J Kaczorowski; Maria L Garcia
Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.
Biochemistry 2003;42(46):13698-707.
2003: Stefan N Gradl; John P Felix; Ehud Y Isacoff; Maria L Garcia; Dirk Trauner
Protein surface recognition by rational design: nanomolar ligands for potassium channels.
Journal of the American Chemical Society 2003;125(42):12668-9.
2003: L K McMillan; R L Carr; Carolyn A Young; J W Astin; R G T Lowe; Emily J Parker; G B Jameson; S C Finch; Christopher O Miles; Owen B McManus; william Schmalhofer; Maria L Garcia; Gregory J Kaczorowski; M Goetz; Jan Tkacz; Barry Scott
Molecular analysis of two cytochrome P450 monooxygenase genes required for paxilline biosynthesis in Penicillium paxilli, and effects of paxilline intermediates on mammalian maxi-K ion channels.
Molecular genetics and genomics : MGG 2003;270(1):9-23.
2003: Ying-Duo Gao; Maria L Garcia
Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels.
Proteins 2003;52(2):146-54.
2003: william Schmalhofer; Robert S Slaughter; Mary Matyskiela; John P Felix; Yui S Tang; Kathleen M Rupprecht; Gregory J Kaczorowski; Maria L Garcia
Di-substituted cyclohexyl derivatives bind to two identical sites with positive cooperativity on the voltage-gated potassium channel, K(v)1.3.
Biochemistry 2003;42(16):4733-43.
2003: Shouwu Miao; Jianming Bao; Maria L Garcia; Joung L Goulet; Xingfang J Hong; Gregory J Kaczorowski; Frank Kayser; Gloria C Koo; Andrew Kotliar; william Schmalhofer; Kashmira Shah; Peter J Sinclair; Robert S Slaughter; Martin S Springer; Mary Jo Staruch; Nancy N Tsou; Frederick Wong; William H Parsons; Kathleen M Rupprecht
Benzamide derivatives as blockers of Kv1.3 ion channel.
Bioorganic & medicinal chemistry letters 2003;13(6):1161-4.
2003: Rosane Vianna-Jorge; Cyntia F Oliveira; Maria L Garcia; Gregory J Kaczorowski; Guilherme Suarez-Kurtz
Shaker-type Kv1 channel blockers increase the peristaltic activity of guinea-pig ileum by stimulating acetylcholine and tachykinins release by the enteric nervous system.
British journal of pharmacology 2003;138(1):57-62.
2002: Nathan Schroeder; Theodore J Mullmann; william Schmalhofer; Ying-Duo Gao; Maria L Garcia; Kathleen M Giangiacomo
Glycine 30 in iberiotoxin is a critical determinant of its specificity for maxi-K versus K(V) channels.
FEBS letters 2002;527(1-3):298-302.
2002: william Schmalhofer; Jianming Bao; Owen B McManus; Brian Green; Mary Matyskiela; Denise Wunderler; Randal M Bugianesi; John P Felix; Markus Hanner; Ana-Rosa Linde-Arias; Cristiano G Ponte; Lucia Velasco; Gloria C Koo; Mary Jo Staruch; Shouwu Miao; William H Parsons; Kathleen M Rupprecht; Robert S Slaughter; Gregory J Kaczorowski; Maria L Garcia
Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties.
Biochemistry 2002;41(24):7781-94.
2002: Steven W Ludmerer; Vivien A Warren; Brande S Williams; Yingcong Zheng; David C Hunt; Michelle B Ayer; Michael A Wallace; Ashok G Chaudhary; Marjorie A Egan; Peter T Meinke; Dennis C Dean; Maria L Garcia; Doris F Cully; McHardy Smith
Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits.
Biochemistry 2002;41(20):6548-60.
2002: Judith Racapé; Alain Lecoq; Régine Romi-Lebrun; Jessica Liu; Martin Kohler; Maria L Garcia; André Ménez; Sylvaine Gasparini
Characterization of a novel radiolabeled peptide selective for a subpopulation of voltage-gated potassium channels in mammalian brain.
The Journal of biological chemistry 2002;277(6):3886-93.
2001: Markus Hanner; Brian Green; Ying-Duo Gao; william Schmalhofer; Mary Matyskiela; Daniel James Durand; John P Felix; A R Linde; C Bordallo; Gregory J Kaczorowski; Martin Kohler; Maria L Garcia
Binding of correolide to the K(v)1.3 potassium channel: characterization of the binding domain by site-directed mutagenesis.
Biochemistry 2001;40(39):11687-97.
2001: Maria L Garcia; Y Gao; Owen B McManus; Gregory J Kaczorowski
Potassium channels: from scorpion venoms to high-resolution structure.
Toxicon : official journal of the International Society on Toxinology 2001;39(6):739-48.
2001: Xiang Dong Tang; H Daggett; Markus Hanner; Maria L Garcia; Owen B McManus; Nathan Brot; Herbert Weissbach; Stefan H Heinemann; Toshinori Hoshi
Oxidative regulation of large conductance calcium-activated potassium channels.
The Journal of general physiology 2001;117(3):253-74.
2000: Rosane Vianna-Jorge; Cyntia F Oliveira; Maria L Garcia; Gregory J Kaczorowski; Guilherme Suarez-Kurtz
Correolide, a nor-triterpenoid blocker of Shaker-type Kv1 channels elicits twitches in guinea-pig ileum by stimulating the enteric nervous system and enhancing neurotransmitter release.
British journal of pharmacology 2000;131(4):772-8.
2000: Kathleen M Giangiacomo; V Fremont; Theodore J Mullmann; Markus Hanner; R H Cox; Maria L Garcia
Interaction of charybdotoxin S10A with single maxi-K channels: kinetics of blockade depend on the presence of the beta 1 subunit.
Biochemistry 2000;39(20):6115-22.
1999: Markus Hanner; william Schmalhofer; Brian Green; C Bordallo; J Liu; Robert S Slaughter; Gregory J Kaczorowski; Maria L Garcia
Binding of correolide to K(v)1 family potassium channels. Mapping the domains of high affinity interaction.
The Journal of biological chemistry 1999;274(36):25237-44.
1999: siegmund wanner; Hartmut Glossmann; Hans-Günther Knaus; R Baker; William H Parsons; Kathleen M Rupprecht; Richard Brochu; charles cohen; william Schmalhofer; McHardy Smith; Vivien A Warren; Maria L Garcia; Gregory J Kaczorowski
WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels.
Biochemistry 1999;38(34):11137-46.
1999: Gregory J Kaczorowski; Maria L Garcia
Pharmacology of voltage-gated and calcium-activated potassium channels.
Current opinion in chemical biology 1999;3(4):448-58.
1999: Guilherme Suarez-Kurtz; Rosane Vianna-Jorge; B F Pereira; Maria L Garcia; Gregory J Kaczorowski
Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release.
The Journal of pharmacology and experimental therapeutics 1999;289(3):1517-22.
1999: siegmund wanner; Robert O Koch; alexandra koschak; Maria Trieb; Maria L Garcia; Gregory J Kaczorowski; Hans-Günther Knaus
High-conductance calcium-activated potassium channels in rat brain: pharmacology, distribution, and subunit composition.
Biochemistry 1999;38(17):5392-400.
1999: John P Felix; Randal M Bugianesi; william Schmalhofer; Robert P Borris; Michael A Goetz; OD Hensens; J M Bao; Frank Kayser; William H Parsons; Kathleen M Rupprecht; Maria L Garcia; Gregory J Kaczorowski; Robert S Slaughter
Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3.
Biochemistry 1999;38(16):4922-30.
1999: Theodore J Mullmann; Petraki Munujos; Maria L Garcia; Kathleen M Giangiacomo
Electrostatic mutations in iberiotoxin as a unique tool for probing the electrostatic structure of the maxi-K channel outer vestibule.
Biochemistry 1999;38(8):2395-402.
1999: Maria L Garcia; Markus Hanner; Hans-Günther Knaus; Robert S Slaughter; Gregory J Kaczorowski
Scorpion toxins as tools for studying potassium channels.
Methods in enzymology 1999;294():624-39.
1999: Maria L Garcia; Kathleen M Giangiacomo; Markus Hanner; Hans-Günther Knaus; Owen B McManus; william Schmalhofer; Gregory J Kaczorowski
Purification and functional reconstitution of high-conductance calcium-activated potassium channel from smooth muscle.
Methods in enzymology 1999;294():274-87.
1998: Maria L Garcia; Markus Hanner; Gregory J Kaczorowski
Scorpion toxins: tools for studying K+ channels.
Toxicon : official journal of the International Society on Toxinology 1998;36(11):1641-50.
1998: Markus Hanner; Rosane Vianna-Jorge; A Kamassah; william Schmalhofer; Hans-Günther Knaus; Gregory J Kaczorowski; Maria L Garcia
The beta subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding.
The Journal of biological chemistry 1998;273(26):16289-96.
1998: Alois Saria; C V Seidl; Hanspeter S Fischer; Robert O Koch; Stefan Telser; siegmund wanner; Christian Humpel; Maria L Garcia; Hans-Günther Knaus
Margatoxin increases dopamine release in rat striatum via voltage-gated K+ channels.
European journal of pharmacology 1998;343(2-3):193-200.
1998: alexandra koschak; Randal M Bugianesi; J Mitterdorfer; Gregory J Kaczorowski; Maria L Garcia; Hans-Günther Knaus
Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom.
The Journal of biological chemistry 1998;273(5):2639-44.
1997: Robert O Koch; siegmund wanner; alexandra koschak; Markus Hanner; Christoph Schwarzer; Gregory J Kaczorowski; Robert S Slaughter; Maria L Garcia; Hans-Günther Knaus
Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology.
The Journal of biological chemistry 1997;272(44):27577-81.
1997: Markus Hanner; william Schmalhofer; Petraki Munujos; Hans-Günther Knaus; Gregory J Kaczorowski; Maria L Garcia
The beta subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2853-8.
1997: L M Helms; John P Felix; Randal M Bugianesi; Maria L Garcia; S Stevens; Reid Leonard; Hans-Günther Knaus; R Koch; siegmund wanner; Gregory J Kaczorowski; Robert S Slaughter
Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells.
Biochemistry 1997;36(12):3737-44.
1997: alexandra koschak; Robert O Koch; J Liu; Gregory J Kaczorowski; P H Reinhart; Maria L Garcia; Hans-Günther Knaus
[125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels.
Biochemistry 1997;36(7):1943-52.
1997: Maria L Garcia; Markus Hanner; Hans-Günther Knaus; R Koch; william Schmalhofer; Robert S Slaughter; Gregory J Kaczorowski
Pharmacology of potassium channels.
Advances in pharmacology (San Diego, Calif.) 1997;39():425-71.
1996: Gregory J Kaczorowski; Hans-Günther Knaus; Reid Leonard; Owen B McManus; Maria L Garcia
High-conductance calcium-activated potassium channels; structure, pharmacology, and function.
Journal of bioenergetics and biomembranes 1996;28(3):255-67.
1996: Hans-Günther Knaus; Christoph Schwarzer; Robert O Koch; A Eberhart; Gregory J Kaczorowski; H Glossmann; F Wunder; O Pongs; Maria L Garcia; Günther Sperk
Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(3):955-63.
1995: Kathleen M Giangiacomo; M Garcia-Calvo; Hans-Günther Knaus; T J Mullmann; Maria L Garcia; Owen B McManus
Functional reconstitution of the large-conductance, calcium-activated potassium channel purified from bovine aortic smooth muscle.
Biochemistry 1995;34(48):15849-62.
1995: Hans-Günther Knaus; Robert O Koch; A Eberhart; Gregory J Kaczorowski; Maria L Garcia; Robert S Slaughter
[125I]margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain.
Biochemistry 1995;34(41):13627-34.
1995: Hans-Günther Knaus; A Eberhart; Robert O Koch; Petraki Munujos; william Schmalhofer; JW Warmke; Gregory J Kaczorowski; Maria L Garcia
Characterization of tissue-expressed alpha subunits of the high conductance Ca(2+)-activated K+ channel.
The Journal of biological chemistry 1995;270(38):22434-9.
1995: Petraki Munujos; Hans-Günther Knaus; Gregory J Kaczorowski; Maria L Garcia
Cross-linking of charybdotoxin to high-conductance calcium-activated potassium channels: identification of the covalently modified toxin residue.
Biochemistry 1995;34(34):10771-6.
1995: Maria L Garcia; Hans-Günther Knaus; Petraki Munujos; Robert S Slaughter; Gregory J Kaczorowski
Charybdotoxin and its effects on potassium channels.
The American journal of physiology 1995;269(1 Pt 1):C1-10.
1994: Hans-Günther Knaus; A Eberhart; H Glossmann; Petraki Munujos; Gregory J Kaczorowski; Maria L Garcia
Pharmacology and structure of high conductance calcium-activated potassium channels.
Cellular signalling 1994;6(8):861-70.
1994: Hans-Günther Knaus; A Eberhart; Gregory J Kaczorowski; Maria L Garcia
Covalent attachment of charybdotoxin to the beta-subunit of the high conductance Ca(2+)-activated K+ channel. Identification of the site of incorporation and implications for channel topology.
The Journal of biological chemistry 1994;269(37):23336-41.
1994: Hans-Günther Knaus; K Folander; M Garcia-Calvo; Maria L Garcia; Gregory J Kaczorowski; McHardy Smith; R Swanson
Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.
The Journal of biological chemistry 1994;269(25):17274-8.
1994: Maria L Garcia; M Garcia-Calvo; P Hidalgo; A Lee; R MacKinnon
Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom.
Biochemistry 1994;33(22):6834-9.
1994: M Garcia-Calvo; Hans-Günther Knaus; Maria L Garcia; Gregory J Kaczorowski; E S Kempner
Functional unit size of the charybdotoxin receptor in smooth muscle.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4718-22.
1994: Hans-Günther Knaus; M Garcia-Calvo; Gregory J Kaczorowski; Maria L Garcia
Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels.
The Journal of biological chemistry 1994;269(6):3921-4.
1994: M Garcia-Calvo; Hans-Günther Knaus; Owen B McManus; Kathleen M Giangiacomo; Gregory J Kaczorowski; Maria L Garcia
Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle.
The Journal of biological chemistry 1994;269(1):676-82.
1993: Hartmut Glossmann; Steffen Hering; Alex Savchenko; W Berger; K Friedrich; Maria L Garcia; Michael A Goetz; J M Liesch; Deborah L Zink; Gregory J Kaczorowski
A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9523-7.
1993: M Garcia-Calvo; Reid Leonard; J Novick; S P Stevens; william Schmalhofer; Gregory J Kaczorowski; Maria L Garcia
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.
The Journal of biological chemistry 1993;268(25):18866-74.
1993: Owen B McManus; G H Harris; Kathleen M Giangiacomo; P Feigenbaum; J P Reuben; M E Addy; John F Burka; Gregory J Kaczorowski; Maria L Garcia
An activator of calcium-dependent potassium channels isolated from a medicinal herb.
Biochemistry 1993;32(24):6128-33.
1993: J C Huang; Maria L Garcia; J P Reuben; G J Kacsorowski
Inhibition of beta-adrenoceptor agonist relaxation of airway smooth muscle by Ca(2+)-activated K+ channel blockers.
European journal of pharmacology 1993;235(1):37-43.
1993: Kathleen M Giangiacomo; E E Sugg; M Garcia-Calvo; Reid Leonard; Owen B McManus; Gregory J Kaczorowski; Maria L Garcia
Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels.
Biochemistry 1993;32(9):2363-70.
1992: John P Felix; V F King; J L Shevell; Maria L Garcia; Gregory J Kaczorowski; I R Bick; Robert S Slaughter
Bis(benzylisoquinoline) analogs of tetrandrine block L-type calcium channels: evidence for interaction at the diltiazem-binding site.
Biochemistry 1992;31(47):11793-800.
1992: Reid Leonard; Maria L Garcia; Robert S Slaughter; J P Reuben
Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10094-8.
1992: Kathleen M Giangiacomo; Maria L Garcia; Owen B McManus
Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle.
Biochemistry 1992;31(29):6719-27.
1991: M Garcia-Calvo; J Vázquez; McHardy Smith; Gregory J Kaczorowski; Maria L Garcia
Characterization of the solubilized charybdotoxin receptor from bovine aortic smooth muscle.
Biochemistry 1991;30(46):11157-64.
1991: Guilherme Suarez-Kurtz; Maria L Garcia; Gregory J Kaczorowski
Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues.
The Journal of pharmacology and experimental therapeutics 1991;259(1):439-43.
1991: Maria L Garcia; A Galvez; M Garcia-Calvo; V F King; J Vazquez; Gregory J Kaczorowski
Use of toxins to study potassium channels.
Journal of bioenergetics and biomembranes 1991;23(4):615-46.
1990: E E Sugg; Maria L Garcia; J P Reuben; Arthur A Patchett; Gregory J Kaczorowski
Synthesis and structural characterization of charybdotoxin, a potent peptidyl inhibitor of the high conductance Ca2(+)-activated K+ channel.
The Journal of biological chemistry 1990;265(31):18745-8.
1990: J Vázquez; P Feigenbaum; V F King; Gregory J Kaczorowski; Maria L Garcia
Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel.
The Journal of biological chemistry 1990;265(26):15564-71.
1990: A Galvez; G Gimenez-Gallego; J P Reuben; L Roy-Contancin; P Feigenbaum; Gregory J Kaczorowski; Maria L Garcia
Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus.
The Journal of biological chemistry 1990;265(19):11083-90.
1990: Maria L Garcia; V F King; J L Shevell; Robert S Slaughter; Guilherme Suarez-Kurtz; R J Winquist; Gregory J Kaczorowski
Amiloride analogs inhibit L-type calcium channels and display calcium entry blocker activity.
The Journal of biological chemistry 1990;265(7):3763-71.
1990: L Roy-Contancin; Maria L Garcia; A Galvez; Gregory J Kaczorowski; G M Katz; D Williams; J P Reuben
Ca2(+)-activated K+ channels in bovine aortic smooth muscle and GH3 cells: properties and regulation by guanine nucleotides.
Progress in clinical and biological research 1990;334():145-70.
1989: J Vázquez; P Feigenbaum; G Katz; V F King; J P Reuben; L Roy-Contancin; Robert S Slaughter; Gregory J Kaczorowski; Maria L Garcia
Characterization of high affinity binding sites for charybdotoxin in sarcolemmal membranes from bovine aortic smooth muscle. Evidence for a direct association with the high conductance calcium-activated potassium channel.
The Journal of biological chemistry 1989;264(35):20902-9.
1989: Gregory J Kaczorowski; Robert S Slaughter; V F King; Maria L Garcia
Inhibitors of sodium-calcium exchange: identification and development of probes of transport activity.
Biochimica et biophysica acta 1989;988(2):287-302.
1989: Robert S Slaughter; J L Shevell; John P Felix; Maria L Garcia; Gregory J Kaczorowski
High levels of sodium-calcium exchange in vascular smooth muscle sarcolemmal membrane vesicles.
Biochemistry 1989;28(9):3995-4002.
1989: V F King; Maria L Garcia; J L Shevell; Robert S Slaughter; Gregory J Kaczorowski
Substituted diphenylbutylpiperidines bind to a unique high affinity site on the L-type calcium channel. Evidence for a fourth site in the cardiac calcium entry blocker receptor complex.
The Journal of biological chemistry 1989;264(10):5633-41.
1988: P K Siegl; Maria L Garcia; V F King; A L Scott; G Morgan; Gregory J Kaczorowski
Interactions of DPI 201-106, a novel cardiotonic agent, with cardiac calcium channels.
Naunyn-Schmiedeberg's archives of pharmacology 1988;338(6):684-91.
1988: Gregory J Kaczorowski; Robert S Slaughter; Maria L Garcia; V F King
The role of sodium-calcium exchange in excitable cells.
Biochemical Society transactions 1988;16(4):529-32.
1988: Gary G Chicchi; G Gimenez-Gallego; E Ber; Maria L Garcia; R Winquist; Margaret A Cascieri
Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom.
The Journal of biological chemistry 1988;263(21):10192-7.
1988: P Feigenbaum; Maria L Garcia; Gregory J Kaczorowski
Evidence for distinct sites coupled to high affinity omega-conotoxin receptors in rat brain synaptic plasma membrane vesicles.
Biochemical and biophysical research communications 1988;154(1):298-305.
1988: G Gimenez-Gallego; M A Navia; J P Reuben; G M Katz; Gregory J Kaczorowski; Maria L Garcia
Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3329-33.
1988: Robert S Slaughter; Maria L Garcia; E J Cragoe; John P Reeves; Gregory J Kaczorowski
Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles. 1. Mechanism of inhibition by amiloride analogues.
Biochemistry 1988;27(7):2403-9.
1988: Maria L Garcia; Robert S Slaughter; V F King; Gregory J Kaczorowski
Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles. 2. Mechanism of inhibition by bepridil.
Biochemistry 1988;27(7):2410-5.
1988: V F King; Maria L Garcia; D Himmel; J P Reuben; Y K Lam; J X Pan; G Q Han; Gregory J Kaczorowski
Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin.
The Journal of biological chemistry 1988;263(5):2238-44.
1988: Gregory J Kaczorowski; Robert S Slaughter; Maria L Garcia; V F King
Block of cardiac sodium-calcium exchange by mechanism-based inhibitors.
Progress in clinical and biological research 1988;252():261-6.
1988: Gregory J Kaczorowski; Maria L Garcia; V F King
Characterization of the calcium entry blocker receptor complex in cardiac sarcolemmal membrane vesicles.
Progress in clinical and biological research 1988;252():29-34.
1987: S B Hwang; M N Chang; Maria L Garcia; Q Q Han; L Huang; V F King; Gregory J Kaczorowski; R J Winquist
L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L.
European journal of pharmacology 1987;141(2):269-81.
1986: Maria L Garcia; V F King; P K Siegl; J P Reuben; Gregory J Kaczorowski
Binding of Ca2+ entry blockers to cardiac sarcolemmal membrane vesicles. Characterization of diltiazem-binding sites and their interaction with dihydropyridine and aralkylamine receptors.
The Journal of biological chemistry 1986;261(18):8146-57.
1984: Maria L Garcia; M J Trumble; J P Reuben; Gregory J Kaczorowski
Characterization of verapamil binding sites in cardiac membrane vesicles.
The Journal of biological chemistry 1984;259(24):15013-6.