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Sylvie Garneau-Tsodikova

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Bacterial Drug Resistance

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Publications

TOP 3
Keith D Green; Sylvie Garneau-Tsodikova
Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6')-IId from Serratia marcescens.
Jacob L Houghton; Abdelrahman S Mayhoub; Rachel E Pricer; Keith D Green; Sylvie Garneau-Tsodikova
Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.
Wenjing Chen; Keith D Green; Sylvie Garneau-Tsodikova
Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis.

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All Publications

2013: Keith D Green; Sylvie Garneau-Tsodikova
Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6')-IId from Serratia marcescens.
Biochimie 2013;95(6):1319-25.
2013: Jacob L Houghton; Abdelrahman S Mayhoub; Rachel E Pricer; Keith D Green; Sylvie Garneau-Tsodikova
Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.
The Journal of antimicrobial chemotherapy 2013;68(4):800-5.
2012: Wenjing Chen; Keith D Green; Sylvie Garneau-Tsodikova
Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2012;56(11):5831-8.
2012: Rachel E Pricer; Keith D Green; Jacob L Houghton; Abdelrahman S Mayhoub; Sylvie Garneau-Tsodikova
Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis.
Molecular bioSystems 2012;8(12):3305-13.
2012: Wenjing Chen; Keith D Green; Oleg V Tsodikov; Sylvie Garneau-Tsodikova
Aminoglycoside multiacetylating activity of the enhanced intracellular survival protein from Mycobacterium smegmatis and its inhibition.
Biochemistry 2012;51(24):4959-67.
2012: Ido M Herzog; Ronit Satchi-Fainaro; Roee R Vidavski; Sylvie Garneau-Tsodikova; Keith D Green; Yifat Berkov-Zrihen; Avigdor Eldar; Anat Eldar-Boock; Mark Feldman; Micha Fridman
6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes.
Angewandte Chemie (International ed. in English) 2012;51(23):5652-6.
2012: Tapan Biswas; Sylvie Garneau-Tsodikova; Jacob L Houghton; Oleg V Tsodikov
The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI.
Protein science : a publication of the Protein Society 2012;21(4):520-30.
2011: Keith D Green; Wenjing Chen; Sylvie Garneau-Tsodikova
Effects of altering aminoglycoside structures on bacterial resistance enzyme activities.
Antimicrobial agents and chemotherapy 2011;55(7):3207-13.
2011: Wenjing Chen; Vanessa R Porter; Oleg V Tsodikov; Tapan Biswas; Sylvie Garneau-Tsodikova
Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(24):9804-8.
2011: Pazit Shaul; Keith D Green; Roi Rutenberg; Maria Kramer; Yifat Berkov-Zrihen; Elinor Breiner-Goldstein; Sylvie Garneau-Tsodikova; Micha Fridman
Assessment of 6'- and 6'''-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance.
Organic & biomolecular chemistry 2011;9(11):4057-63.
2011: Ahmed S A Mady; Olga E Zolova; María Álvarez San Millán; Germán Villamizar; Felipe Lombó; Fernando de la Calle; Sylvie Garneau-Tsodikova
Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster.
Molecular bioSystems 2011;7(6):1999-2011.
2010: Vanessa R Porter; Keith D Green; Olga E Zolova; Jacob L Houghton; Sylvie Garneau-Tsodikova
Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4').
Biochemical and biophysical research communications 2010;403(1):85-90.
2010: Olga E Zolova; Ahmed S A Mady; Sylvie Garneau-Tsodikova
Recent developments in bisintercalator natural products.
Biopolymers 2010;93(9):777-90.
2010: Sylvie Garneau-Tsodikova
Special series: natural products at the core of drug discovery.
Biopolymers 2010;93(9):753-4.
2010: Keith D Green; Vanessa R Porter; Yaru Zhang; Sylvie Garneau-Tsodikova
Redesign of cosubstrate specificity and identification of important residues for substrate binding to hChAT.
Biochemistry 2010;49(29):6219-27.
2010: Jacob L Houghton; Keith D Green; Wenjing Chen; Sylvie Garneau-Tsodikova
The future of aminoglycosides: the end or renaissance?
Chembiochem : a European journal of chemical biology 2010;11(7):880-902.
2010: Tapan Biswas; Olga E Zolova; Felipe Lombó; Fernando de la Calle; Jose A Salas; Oleg V Tsodikov; Sylvie Garneau-Tsodikova
A new scaffold of an old protein fold ensures binding to the bisintercalator thiocoraline.
Journal of molecular biology 2010;397(2):495-507.
2010: Keith D Green; Wenjing Chen; Jacob L Houghton; Micha Fridman; Sylvie Garneau-Tsodikova
Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides.
Chembiochem : a European journal of chemical biology 2010;11(1):119-26.
2009: Keith D Green; Micha Fridman; Sylvie Garneau-Tsodikova
hChAT: a tool for the chemoenzymatic generation of potential acetyl/butyrylcholinesterase inhibitors.
Chembiochem : a European journal of chemical biology 2009;10(13):2191-4.
2009: Sylvie Garneau-Tsodikova; Irina A Shkel; Oleg V Tsodikov
Exact and user-friendly kinetic analysis of the two-step rapid equilibrium Michaelis-Menten mechanism.
Analytical biochemistry 2009;387(2):276-9.
2009: Thomas J McQuade; Abbie D Shallop; Anita Sheoran; James E Delproposto; Oleg V Tsodikov; Sylvie Garneau-Tsodikova
A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis.
Analytical biochemistry 2009;386(2):244-50.
2009: Michael H T Li; Peter M U Ung; James Zajkowski; Sylvie Garneau-Tsodikova; David H Sherman
Automated genome mining for natural products.
BMC bioinformatics 2009;10():185.
2008: Leah A Martin-Visscher; Marco J van Belkum; Sylvie Garneau-Tsodikova; Randy M Whittal; Jing Zheng; Lynn M McMullen; John C Vederas
Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307.
Applied and environmental microbiology 2008;74(15):4756-63.
2008: Anita Sheoran; Andrew King; Ana Velasco; Jessica M Pero; Sylvie Garneau-Tsodikova
Characterization of TioF, a tryptophan 2,3-dioxygenase involved in 3-hydroxyquinaldic acid formation during thiocoraline biosynthesis.
Molecular bioSystems 2008;4(6):622-8.
2008: Sylvie Garneau-Tsodikova; Victor J Thannickal
Protein kinase inhibitors in the treatment of pulmonary fibrosis.
Current medicinal chemistry 2008;15(25):2632-40.
2007: Micha Fridman; Carl J Balibar; Tania Lupoli; Daniel Kahne; Christopher T Walsh; Sylvie Garneau-Tsodikova
Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7.
Biochemistry 2007;46(28):8462-71.
2007: Carl J Balibar; Sylvie Garneau-Tsodikova; Christopher T Walsh
Covalent CouN7 enzyme intermediate for acyl group shuttling in aminocoumarin biosynthesis.
Chemistry & biology 2007;14(6):679-90.
2006: Masashi Ueki; Danica P Galonić; Frédéric H Vaillancourt; Sylvie Garneau-Tsodikova; Ellen Yeh; David A Vosburg; Frank Schroeder; Hiroyuki Osada; Christopher T Walsh
Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.
Chemistry & biology 2006;13(11):1183-91.
2006: Pieter dorrestein; Stefanie Bumpus; Christopher T Calderone; Sylvie Garneau-Tsodikova; Zachary D Aron; Paul D Straight; Roberto Kolter; Christopher T Walsh; Neil L Kelleher
Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry.
Biochemistry 2006;45(42):12756-66.
2006: Sylvie Garneau-Tsodikova; Pieter dorrestein; Neil L Kelleher; Christopher T Walsh
Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J.
Journal of the American Chemical Society 2006;128(39):12600-1.
2006: Frédéric H Vaillancourt; Ellen Yeh; David A Vosburg; Sylvie Garneau-Tsodikova; Christopher T Walsh
Nature's inventory of halogenation catalysts: oxidative strategies predominate.
Chemical reviews 2006;106(8):3364-78.
2006: Christopher T Walsh; Sylvie Garneau-Tsodikova; Annaleise R Howard-Jones
Biological formation of pyrroles: nature's logic and enzymatic machinery.
Natural product reports 2006;23(4):517-31.
2006: Sylvie Garneau-Tsodikova; Anthony Stapon; Daniel Kahne; Christopher T Walsh
Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1.
Biochemistry 2006;45(28):8568-78.
2006: Pieter dorrestein; Jonathan Blackhall; Paul D Straight; Michael A Fischbach; Sylvie Garneau-Tsodikova; Daniel J Edwards; Shaun McLaughlin; Myat Lin; William H Gerwick; Roberto Kolter; Christopher T Walsh; Neil L Kelleher
Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry.
Biochemistry 2006;45(6):1537-46.
2005: Christopher T Walsh; Sylvie Garneau-Tsodikova; Gregory J Gatto
Protein posttranslational modifications: the chemistry of proteome diversifications.
Angewandte Chemie (International ed. in English) 2005;44(45):7342-72.
2005: Pieter dorrestein; Ellen Yeh; Sylvie Garneau-Tsodikova; Neil L Kelleher; Christopher T Walsh
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13843-8.