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James Apriletti

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Leandro Martínez; Alessandro S Nascimento; Fabio M Nunes; Kevin Phillips; Ricardo Aparicio; Sandra Martha G Dias; Ana Carolina M Figueira; Jean H Lin; Phuong Nguyen; James W Apriletti; Francisco A R Neves; John D Baxter; Paul Webb; Munir S Skaf; Igor Polikarpov
Gaining ligand selectivity in thyroid hormone receptors via entropy.
Suzana T Cunha Lima; Ngoc-Ha Nguyen; Marie Togashi; James W Apriletti; Phuong Nguyen; Igor Polikarpov; Thomas S Scanlan; John D Baxter; Paul Webb
Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways.
Ana Carolina M Figueira; Sandra M G Dias; Maria A M Santos; James W Apriletti; John D Baxter; Paul Webb; Francisco A R Neves; Luiz Simeoni; Ralff C J Ribeiro; Igor Polikarpov
Human thyroid receptor forms tetramers in solution, which dissociate into dimers upon ligand binding.

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All Publications

2009: Leandro Martínez; Alessandro S Nascimento; Fabio M Nunes; Kevin Phillips; Ricardo Aparicio; Sandra Martha G Dias; Ana Carolina M Figueira; Jean H Lin; Phuong Nguyen; James W Apriletti; Francisco A R Neves; John D Baxter; Paul Webb; Munir S Skaf; Igor Polikarpov
Gaining ligand selectivity in thyroid hormone receptors via entropy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20717-22.
2009: Suzana T Cunha Lima; Ngoc-Ha Nguyen; Marie Togashi; James W Apriletti; Phuong Nguyen; Igor Polikarpov; Thomas S Scanlan; John D Baxter; Paul Webb
Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways.
The Journal of steroid biochemistry and molecular biology 2009;117(4-5):125-31.
2006: Ana Carolina M Figueira; Sandra M G Dias; Maria A M Santos; James W Apriletti; John D Baxter; Paul Webb; Francisco A R Neves; Luiz Simeoni; Ralff C J Ribeiro; Igor Polikarpov
Human thyroid receptor forms tetramers in solution, which dissociate into dimers upon ligand binding.
Cell biochemistry and biophysics 2006;44(3):453-62.
2005: Ngoc-Ha Nguyen; James W Apriletti; John D Baxter; Thomas S Scanlan
Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists.
Journal of the American Chemical Society 2005;127(13):4599-608.
2004: Ben Sandler; Paul Webb; James W Apriletti; B Russell Huber; Marie Togashi; Suzana T Cunha Lima; Sanja Juric; Stefan Nilsson; Richard Wagner; Robert J Fletterick; John D Baxter
Thyroxine-thyroid hormone receptor interactions.
The Journal of biological chemistry 2004;279(53):55801-8.
2004: John D Baxter; John W Funder; James W Apriletti; Paul Webb
Towards selectively modulating mineralocorticoid receptor function: lessons from other systems.
Molecular and cellular endocrinology 2004;217(1-2):151-65.
2003: Hikari A I Yoshihara; James W Apriletti; John D Baxter; Thomas S Scanlan
Structural determinants of selective thyromimetics.
Journal of medicinal chemistry 2003;46(14):3152-61.
2003: Hannes Fischer; Sandra M G Dias; Maria A M Santos; Adriana C Alves; Nilson Zanchin; Aldo F Craievich; James W Apriletti; John D Baxter; Paul Webb; Francisco A R Neves; Ralff C J Ribeiro; Igor Polikarpov
Low resolution structures of the retinoid X receptor DNA-binding and ligand-binding domains revealed by synchrotron X-ray solution scattering.
The Journal of biological chemistry 2003;278(18):16030-8.
2003: B Russell Huber; Ben Sandler; Brian L West; Suzana T Cunha Lima; Hoa T Nguyen; James W Apriletti; John D Baxter; Robert J Fletterick
Two resistance to thyroid hormone mutants with impaired hormone binding.
Molecular endocrinology (Baltimore, Md.) 2003;17(4):643-52.
2002: Hege Berghagen; Erlend Ragnhildstveit; Kristin Krogsrud; Gunnar Thuestad; James W Apriletti; Fahri Saatcioglu
Corepressor SMRT functions as a coactivator for thyroid hormone receptor T3Ralpha from a negative hormone response element.
The Journal of biological chemistry 2002;277(51):49517-22.
2002: Paul Webb; Ngoc-Ha Nguyen; Grazia Chiellini; Hikari A I Yoshihara; Suzana T Cunha Lima; James W Apriletti; Ralff C J Ribeiro; Adhirai Marimuthu; Brian L West; Patrick Goede; Karin Mellström; Stefan Nilsson; Peter J Kushner; Robert J Fletterick; Thomas S Scanlan; John D Baxter
Design of thyroid hormone receptor antagonists from first principles.
The Journal of steroid biochemistry and molecular biology 2002;83(1-5):59-73.
2002: Ngoc-Ha Nguyen; James W Apriletti; Suzana T Cunha Lima; Paul Webb; John D Baxter; Thomas S Scanlan
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.
Journal of medicinal chemistry 2002;45(15):3310-20.
2002: John D Baxter; Patrick Goede; James W Apriletti; Brian L West; Weijun Feng; Karin Mellström; Robert J Fletterick; Richard L Wagner; Peter J Kushner; Ralff C J Ribeiro; Paul Webb; Thomas S Scanlan; Stefan Nilsson
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist.
Endocrinology 2002;143(2):517-24.
2002: Grazia Chiellini; Ngoc-Ha Nguyen; James W Apriletti; John D Baxter; Thomas S Scanlan
Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives.
Bioorganic & medicinal chemistry 2002;10(2):333-46.
2001: Hikari A I Yoshihara; James W Apriletti; John D Baxter; Thomas S Scanlan
A designed antagonist of the thyroid hormone receptor.
Bioorganic & medicinal chemistry letters 2001;11(21):2821-5.
2001: Ralff C J Ribeiro; Weijun Feng; Richard L Wagner; C H Costa; A C Pereira; James W Apriletti; Robert J Fletterick; John D Baxter
Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor.
The Journal of biological chemistry 2001;276(18):14987-95.
2001: Richard L Wagner; B Russell Huber; A K Shiau; A Kelly; Suzana T Cunha Lima; Thomas S Scanlan; James W Apriletti; John D Baxter; Brian L West; Robert J Fletterick
Hormone selectivity in thyroid hormone receptors.
Molecular endocrinology (Baltimore, Md.) 2001;15(3):398-410.
2001: John D Baxter; W H Dillmann; Brian L West; R Huber; J David Furlow; Robert J Fletterick; Paul Webb; James W Apriletti; Thomas S Scanlan
Selective modulation of thyroid hormone receptor action.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):31-42.
2000: G Thuestad; I Kraus; James W Apriletti; Fahri Saatcioglu
The N-terminal domain of thyroid hormone receptor-alpha is required for its biological activities.
DNA and cell biology 2000;19(7):389-99.
1998: James W Apriletti; Ralff C J Ribeiro; Richard L Wagner; Weijun Feng; Paul Webb; Peter J Kushner; Brian L West; Stefan Nilsson; Thomas S Scanlan; Robert J Fletterick; John D Baxter
Molecular and structural biology of thyroid hormone receptors.
Clinical and experimental pharmacology & physiology. Supplement 1998;25():S2-11.
1998: Beatrice D Darimont; Richard L Wagner; James W Apriletti; Michael R Stallcup; Peter J Kushner; John D Baxter; Robert J Fletterick; Keith R Yamamoto
Structure and specificity of nuclear receptor-coactivator interactions.
Genes & development 1998;12(21):3343-56.
1998: S Chin; James W Apriletti; G Gick
Characterization of a negative thyroid hormone response element in the rat sodium, potassium-adenosine triphosphatase alpha3 gene promoter.
Endocrinology 1998;139(8):3423-31.
1998: Weijun Feng; Ralff C J Ribeiro; Richard L Wagner; Hoa Nguyen; James W Apriletti; Robert J Fletterick; John D Baxter; Peter J Kushner; Brian L West
Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors.
Science (New York, N.Y.) 1998;280(5370):1747-9.
1998: Grazia Chiellini; James W Apriletti; Hikari A I Yoshihara; John D Baxter; Ralff C J Ribeiro; Thomas S Scanlan
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor.
Chemistry & biology 1998;5(6):299-306.
1998: Ralff C J Ribeiro; James W Apriletti; Richard L Wagner; Weijun Feng; Peter J Kushner; Stefan Nilsson; Thomas S Scanlan; Brian L West; Robert J Fletterick; John D Baxter
X-ray crystallographic and functional studies of thyroid hormone receptor.
The Journal of steroid biochemistry and molecular biology 1998;65(1-6):133-41.
1998: Ralff C J Ribeiro; James W Apriletti; Richard L Wagner; Brian L West; Weijun Feng; Robert Huber; Peter J Kushner; Stefan Nilsson; Thomas S Scanlan; Robert J Fletterick; Fred Schaufele; John D Baxter
Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.
Recent progress in hormone research 1998;53():351-92; discussion 392-4.
1997: F Saatcioglu; G Lopez; Brian L West; E Zandi; Weijun Feng; H Lu; A Esmaili; James W Apriletti; Peter J Kushner; John D Baxter; Michael Karin
Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.
Molecular and cellular biology 1997;17(8):4687-95.
1996: H He; S Chin; K Zhuang; R Hartong; James W Apriletti; G Gick
Negative regulation of the rat Na-K-ATPase alpha 3-subunit gene promoter by thyroid hormone.
The American journal of physiology 1996;271(5 Pt 1):C1750-6.
1995: Richard L Wagner; James W Apriletti; M E McGrath; Brian L West; John D Baxter; Robert J Fletterick
A structural role for hormone in the thyroid hormone receptor.
Nature 1995;378(6558):690-7.
1995: Ralff C J Ribeiro; James W Apriletti; Brian L West; Richard L Wagner; Robert J Fletterick; Fred Schaufele; John D Baxter
The molecular biology of thyroid hormone action.
Annals of the New York Academy of Sciences 1995;758():366-89.
1995: James W Apriletti; John D Baxter; K H Lau; Brian L West
Expression of the rat alpha 1 thyroid hormone receptor ligand binding domain in Escherichia coli and the use of a ligand-induced conformation change as a method for its purification to homogeneity.
Protein expression and purification 1995;6(3):363-70.
1994: Ralff C J Ribeiro; James W Apriletti; Paul M Yen; William W Chin; John D Baxter
Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor.
Endocrinology 1994;135(5):2076-85.
1994: R Hartong; N Wang; R Kurokawa; Mitchell Lazar; Christopher K Glass; James W Apriletti; Wolfgang H Dillmann
Delineation of three different thyroid hormone-response elements in promoter of rat sarcoplasmic reticulum Ca2+ATPase gene. Demonstration that retinoid X receptor binds 5' to thyroid hormone receptor in response element 1.
The Journal of biological chemistry 1994;269(17):13021-9.
1994: M E McGrath; Richard L Wagner; James W Apriletti; Brian L West; V Ramalingam; John D Baxter; Robert J Fletterick
Preliminary crystallographic studies of the ligand-binding domain of the thyroid hormone receptor complexed with triiodothyronine.
Journal of molecular biology 1994;237(2):236-9.
1994: Paul M Yen; J H Brubaker; James W Apriletti; John D Baxter; William W Chin
Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation.
Endocrinology 1994;134(3):1075-81.
1994: A Sugawara; Paul M Yen; James W Apriletti; Ralff C J Ribeiro; David B Sacks; John D Baxter; William W Chin
Phosphorylation selectively increases triiodothyronine receptor homodimer binding to DNA.
The Journal of biological chemistry 1994;269(1):433-7.
1992: Ralff C J Ribeiro; Peter J Kushner; James W Apriletti; Brian L West; John D Baxter
Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptors.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):1142-52.
1988: James W Apriletti; John D Baxter; T N Lavin
Large scale purification of the nuclear thyroid hormone receptor from rat liver and sequence-specific binding of the receptor to DNA.
The Journal of biological chemistry 1988;263(19):9409-17.