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Wolfgang Garten

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Daniela Meyer; Frank Sielaff; Eva Böttcher-Friebertshäuser; Wolfgang Garten; Maya Hammami; Torsten Steinmetzer
Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.
Joanna Baron; Wolfgang Garten; Yi Guan; Maya Hammami; Hans-Dieter Klenk; Deborah Mayoli-Nüssle; Daniela Meyer; Eva Schilling; Folker Schwalm; Torsten Steinmetzer; Carolin Tarnow; Eva Böttcher-Friebertshäuser
Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.
Frank Sielaff; Ines M Volk; Eva Böttcher-Friebertshäuser; Wolfgang Garten; Daniela Meyer; Sebastian M Saupe; Torsten Steinmetzer
Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.

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2013: Daniela Meyer; Frank Sielaff; Eva Böttcher-Friebertshäuser; Wolfgang Garten; Maya Hammami; Torsten Steinmetzer
Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.
The Biochemical journal 2013;452(2):331-43.
2013: Joanna Baron; Wolfgang Garten; Yi Guan; Maya Hammami; Hans-Dieter Klenk; Deborah Mayoli-Nüssle; Daniela Meyer; Eva Schilling; Folker Schwalm; Torsten Steinmetzer; Carolin Tarnow; Eva Böttcher-Friebertshäuser
Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.
Journal of virology 2013;87(3):1811-20.
2011: Frank Sielaff; Ines M Volk; Eva Böttcher-Friebertshäuser; Wolfgang Garten; Daniela Meyer; Sebastian M Saupe; Torsten Steinmetzer
Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.
Bioorganic & medicinal chemistry letters 2011;21(16):4860-4.
2011: Hans D Klenk; Wolfgang Garten; Mikhail Matrosovich
Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: Lessons from the 2009 pandemic.
BioEssays : news and reviews in molecular, cellular and developmental biology 2011;33(3):180-8.
2011: Eva Böttcher-Friebertshäuser; David A Stein; Hans-Dieter Klenk; Wolfgang Garten
Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2.
Journal of virology 2011;85(4):1554-62.
2010: Katrin Schlie; Thomas Strecker; Wolfgang Garten
Maturation cleavage within the ectodomain of Lassa virus glycoprotein relies on stabilization by the cytoplasmic tail.
FEBS letters 2010;584(21):4379-82.
2010: Eva Böttcher-Friebertshäuser; Catharina Freuer; Frank Sielaff; Sarah Schmidt; Markus Eickmann; Jennifer Uhlendorff; Torsten Steinmetzer; Hans-Dieter Klenk; Wolfgang Garten
Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors.
Journal of virology 2010;84(11):5605-14.
2010: Katrin Schlie; Anna Maisa; Fabian Freiberg; Allison Groseth; Thomas Strecker; Wolfgang Garten
Viral protein determinants of Lassa virus entry and release from polarized epithelial cells.
Journal of virology 2010;84(7):3178-88.
2010: Gero L Becker; Frank Sielaff; Manuel E Than; Iris Lindberg; Sophie Routhier; Robert Day; Yinghui Lu; Wolfgang Garten; Torsten Steinmetzer
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.
Journal of medicinal chemistry 2010;53(3):1067-75.
2010: Katrin Schlie; Anna Maisa; Frank Lennartz; Ute Ströher; Wolfgang Garten; Thomas Strecker
Characterization of Lassa virus glycoprotein oligomerization and influence of cholesterol on virus replication.
Journal of virology 2010;84(2):983-92.
2009: Eva Böttcher; Catharina Freuer; Torsten Steinmetzer; Hans-Dieter Klenk; Wolfgang Garten
MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition.
Vaccine 2009;27(45):6324-9.
2009: Anna Maisa; Ute Ströher; Hans-Dieter Klenk; Wolfgang Garten; Thomas Strecker
Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants.
PLoS neglected tropical diseases 2009;3(6):e446.
2007: Mikhail Matrosovich; Tatyana Matrosovich; Jennifer Uhlendorff; Wolfgang Garten; Hans-Dieter Klenk
Avian-virus-like receptor specificity of the hemagglutinin impedes influenza virus replication in cultures of human airway epithelium.
Virology 2007;361(2):384-90.
2007: Eva Mittler; Larissa Kolesnikova; Thomas Strecker; Wolfgang Garten; Stephan Becker
Role of the transmembrane domain of marburg virus surface protein GP in assembly of the viral envelope.
Journal of virology 2007;81(8):3942-8.
2006: Eva Böttcher; Tatyana Matrosovich; Michaela Beyerle; Hans-Dieter Klenk; Wolfgang Garten; Mikhail Matrosovich
Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium.
Journal of virology 2006;80(19):9896-8.
2006: Mikhail Matrosovich; Takashi Suzuki; Yoshio Hirabayashi; Wolfgang Garten; Robert G Webster; Hans-Dieter Klenk
Gangliosides are not essential for influenza virus infection.
Glycoconjugate journal 2006;23(1-2):107-13.
2006: Thomas Strecker; Anna Maisa; Stephane Daffis; Robert Eichler; Oliver Lenz; Wolfgang Garten
The role of myristoylation in the membrane association of the Lassa virus matrix protein Z.
Virology journal 2006;3():93.
2006: Mikhail Matrosovich; Tatyana Matrosovich; Wolfgang Garten; Hans-Dieter Klenk
New low-viscosity overlay medium for viral plaque assays.
Virology journal 2006;3():63.
2006: Robert Eichler; Oliver Lenz; Wolfgang Garten; Thomas Strecker
The role of single N-glycans in proteolytic processing and cell surface transport of the Lassa virus glycoprotein GP-C.
Virology journal 2006;3():41.
2005: Markus Eickmann; Simone Kiermayer; Ina Kraus; Melanie Gössl; Juergen A Richt; Wolfgang Garten
Maturation of Borna disease virus glycoprotein.
FEBS letters 2005;579(21):4751-6.
2005: Ina Kraus; Elke Bogner; Hauke Lilie; Markus Eickmann; Wolfgang Garten
Oligomerization and assembly of the matrix protein of Borna disease virus.
FEBS letters 2005;579(12):2686-92.
2004: Olga Dolnik; Valentina Volchkova; Wolfgang Garten; Caroline Carbonnelle; Stephan Becker; Jörg Kahnt; Ute Ströher; Hans-Dieter Klenk; Viktor Volchkov
Ectodomain shedding of the glycoprotein GP of Ebola virus.
The EMBO journal 2004;23(10):2175-84.
2004: Robert Eichler; Oliver Lenz; Thomas Strecker; Markus Eickmann; Hans-Dieter Klenk; Wolfgang Garten
Lassa virus glycoprotein signal peptide displays a novel topology with an extended endoplasmic reticulum luminal region.
The Journal of biological chemistry 2004;279(13):12293-9.
2004: Robert Eichler; Thomas Strecker; Larissa Kolesnikova; Jan ter Meulen; Winfried Weissenhorn; Stephan Becker; Hans-Dieter Klenk; Wolfgang Garten; Oliver Lenz
Characterization of the Lassa virus matrix protein Z: electron microscopic study of virus-like particles and interaction with the nucleoprotein (NP).
Virus research 2004;100(2):249-55.
2003: Robert Eichler; Oliver Lenz; Thomas Strecker; Markus Eickmann; Hans-Dieter Klenk; Wolfgang Garten
Identification of Lassa virus glycoprotein signal peptide as a trans-acting maturation factor.
EMBO reports 2003;4(11):1084-8.
2003: Markus G Rudolph; Ina Kraus; Achim Dickmanns; Markus Eickmann; Wolfgang Garten; Ralf Ficner
Crystal structure of the borna disease virus nucleoprotein.
Structure (London, England : 1993) 2003;11(10):1219-26.
2003: Thomas Strecker; Robert Eichler; Jan ter Meulen; Winfried Weissenhorn; Hans Dieter Klenk; Wolfgang Garten; Oliver Lenz
Lassa virus Z protein is a matrix protein and sufficient for the release of virus-like particles [corrected].
Journal of virology 2003;77(19):10700-5.
2003: Robert Eichler; Oliver Lenz; Thomas Strecker; Wolfgang Garten
Signal peptide of Lassa virus glycoprotein GP-C exhibits an unusual length.
FEBS letters 2003;538(1-3):203-6.
2003: Winfried R Beyer; Dennis Pöpplau; Wolfgang Garten; Dorothee von Laer; Oliver Lenz
Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P.
Journal of virology 2003;77(5):2866-72.
2002: Simone Kiermayer; Ina Kraus; Juergen A Richt; Wolfgang Garten; Markus Eickmann
Identification of the amino terminal subunit of the glycoprotein of Borna disease virus.
FEBS letters 2002;531(2):255-8.
2002: Ina Kraus; Hanno Scheffczik; Markus Eickmann; Simone Kiermayer; Milton T Stubbs; Wolfgang Garten
Crystallization and preliminary X-ray analysis of the matrix protein of Borna disease virus.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 8):1371-3.
2001: Ina Kraus; Markus Eickmann; Simone Kiermayer; Hanno Scheffczik; M Fluess; Juergen A Richt; Wolfgang Garten
Open reading frame III of borna disease virus encodes a nonglycosylated matrix protein.
Journal of virology 2001;75(24):12098-104.
2001: Oliver Lenz; Jan ter Meulen; Hans-Dieter Klenk; N G Seidah; Wolfgang Garten
The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12701-5.
2001: Hanno Scheffczik; Ina Kraus; Simone Kiermayer; Elke Bogner; Andreas Holzenburg; Wolfgang Garten; Markus Eickmann
Multimerization potential of the cytoplasmic domain of the human cytomegalovirus glycoprotein B.
FEBS letters 2001;506(2):113-6.
2000: Oliver Lenz; Jan ter Meulen; H Feldmann; Hans-Dieter Klenk; Wolfgang Garten
Identification of a novel consensus sequence at the cleavage site of the Lassa virus glycoprotein.
Journal of virology 2000;74(23):11418-21.
2000: A Feldmann; M K Schäfer; Wolfgang Garten; Hans-Dieter Klenk
Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos.
Journal of virology 2000;74(17):8018-27.
2000: A Berting; C Fischer; Stephan Schaefer; Wolfgang Garten; Hans-Dieter Klenk; W H Gerlich
Hemifusion activity of a chimeric influenza virus hemagglutinin with a putative fusion peptide from hepatitis B virus.
Virus research 2000;68(1):35-49.
2000: Viktor Volchkov; Valentina Volchkova; Ute Ströher; Stephan Becker; Olga Dolnik; M Cieplik; Wolfgang Garten; Hans-Dieter Klenk; Heinz Feldmann
Proteolytic processing of Marburg virus glycoprotein.
Virology 2000;268(1):1-6.
1999: M Teuchert; S Berghöfer; Hans-Dieter Klenk; Wolfgang Garten
Recycling of furin from the plasma membrane. Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit.
The Journal of biological chemistry 1999;274(51):36781-9.
1999: M Teuchert; W Schäfer; S Berghöfer; B Hoflack; Hans-Dieter Klenk; Wolfgang Garten
Sorting of furin at the trans-Golgi network. Interaction of the cytoplasmic tail sorting signals with AP-1 Golgi-specific assembly proteins.
The Journal of biological chemistry 1999;274(12):8199-207.
1999: M Moulard; S Hallenberger; Wolfgang Garten; H D Klenk
Processing and routage of HIV glycoproteins by furin to the cell surface.
Virus research 1999;60(1):55-65.
1999: A Stroh; W Schäfer; S Berghöfer; Markus Eickmann; M Teuchert; I Bürger; Hans-Dieter Klenk; Wolfgang Garten
A mono phenylalanine-based motif (F790) and a leucine-dependent motif (LI760) mediate internalization of furin.
European journal of cell biology 1999;78(3):151-60.
1999: Wolfgang Garten; Hans-Dieter Klenk
Understanding influenza virus pathogenicity.
Trends in microbiology 1999;7(3):99-100.
1998: M Cieplik; Hans-Dieter Klenk; Wolfgang Garten
Identification and characterization of spodoptera frugiperda furin: a thermostable subtilisin-like endopeptidase.
Biological chemistry 1998;379(12):1433-40.
1998: C Fischer; B Schroth-Diez; A Herrmann; Wolfgang Garten; Hans-Dieter Klenk
Acylation of the influenza hemagglutinin modulates fusion activity.
Virology 1998;248(2):284-94.
1998: Juergen A Richt; T Fürbringer; A Koch; I Pfeuffer; Christiane Herden; I Bause-Niedrig; Wolfgang Garten
Processing of the Borna disease virus glycoprotein gp94 by the subtilisin-like endoprotease furin.
Journal of virology 1998;72(5):4528-33.
1997: J Hausmann; E Kretzschmar; Wolfgang Garten; Hans-Dieter Klenk
Biosynthesis, intracellular transport and enzymatic activity of an avian influenza A virus neuraminidase: role of unpaired cysteines and individual oligosaccharides.
The Journal of general virology 1997;78 ( Pt 12)():3233-45.
1997: Reiko Ohuchi; Masanobu Ohuchi; Wolfgang Garten; Hans-Dieter Klenk
Oligosaccharides in the stem region maintain the influenza virus hemagglutinin in the metastable form required for fusion activity.
Journal of virology 1997;71(5):3719-25.
1997: S Hallenberger; M Moulard; M Sordel; Hans-Dieter Klenk; Wolfgang Garten
The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells.
Journal of virology 1997;71(2):1036-45.
1996: S Bold; Mats Ohlin; Wolfgang Garten; Klaus Radsak
Structural domains involved in human cytomegalovirus glycoprotein B-mediated cell-cell fusion.
The Journal of general virology 1996;77 ( Pt 9)():2297-302.
1995: J Hausmann; E Kretzschmar; Wolfgang Garten; Hans-Dieter Klenk
N1 neuraminidase of influenza virus A/FPV/Rostock/34 has haemadsorbing activity.
The Journal of general virology 1995;76 ( Pt 7)():1719-28.
1995: W Schäfer; A Stroh; S Berghöfer; J Seiler; M Vey; M L Kruse; H F Kern; Hans-Dieter Klenk; Wolfgang Garten
Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.
The EMBO journal 1995;14(11):2424-35.
1995: John W M Creemers; M Vey; W Schäfer; Torik A Y Ayoubi; Anton J M Roebroek; Hans-Dieter Klenk; Wolfgang Garten; Wim J M Van De Ven
Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum.
The Journal of biological chemistry 1995;270(6):2695-702.
1995: M Vey; W Schäfer; B Reis; Reiko Ohuchi; W Britt; Wolfgang Garten; Hans-Dieter Klenk; Klaus Radsak
Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.
Virology 1995;206(1):746-9.
1995: Marko Reschke; B Reis; K Nöding; D Rohsiepe; A Richter; T Mockenhaupt; Wolfgang Garten; Klaus Radsak
Constitutive expression of human cytomegalovirus glycoprotein B (gpUL55) with mutagenized carboxy-terminal hydrophobic domains.
The Journal of general virology 1995;76 ( Pt 1)():113-22.
1994: M Vey; W Schäfer; S Berghöfer; Hans-Dieter Klenk; Wolfgang Garten
Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation.
The Journal of cell biology 1994;127(6 Pt 2):1829-42.
1994: D Ortmann; Masanobu Ohuchi; H Angliker; E Shaw; Wolfgang Garten; Hans-Dieter Klenk
Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2.
Journal of virology 1994;68(4):2772-6.
1994: Masanobu Ohuchi; A Cramer; M Vey; Reiko Ohuchi; Wolfgang Garten; Hans-Dieter Klenk
Rescue of vector-expressed fowl plague virus hemagglutinin in biologically active form by acidotropic agents and coexpressed M2 protein.
Journal of virology 1994;68(2):920-6.
1994: Hans-Dieter Klenk; Wolfgang Garten
Host cell proteases controlling virus pathogenicity.
Trends in microbiology 1994;2(2):39-43.
1994: Wolfgang Garten; S Hallenberger; D Ortmann; W Schäfer; M Vey; H Angliker; E Shaw; Hans-Dieter Klenk
Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones.
Biochimie 1994;76(3-4):217-25.
1993: P C Roberts; Wolfgang Garten; Hans-Dieter Klenk
Role of conserved glycosylation sites in maturation and transport of influenza A virus hemagglutinin.
Journal of virology 1993;67(6):3048-60.
1993: I Günther; B Glatthaar; G Döller; Wolfgang Garten
A H1 hemagglutinin of a human influenza A virus with a carbohydrate-modulated receptor binding site and an unusual cleavage site.
Virus research 1993;27(2):147-60.
1992: S Hallenberger; V Bosch; H Angliker; E Shaw; Hans-Dieter Klenk; Wolfgang Garten
Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160.
Nature 1992;360(6402):358-61.
1992: A Stieneke-Gröber; M Vey; H Angliker; E Shaw; Gary Thomas; C Roberts; Hans-Dieter Klenk; Wolfgang Garten
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.
The EMBO journal 1992;11(7):2407-14.
1992: K Munk; E Pritzer; E Kretzschmar; B Gutte; Wolfgang Garten; Hans-Dieter Klenk
Carbohydrate masking of an antigenic epitope of influenza virus haemagglutinin independent of oligosaccharide size.
Glycobiology 1992;2(3):233-40.
1992: M Vey; M Orlich; S Adler; Hans-Dieter Klenk; R Rott; Wolfgang Garten
Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R.
Virology 1992;188(1):408-13.
1992: Wolfgang Garten; Cindy L Will; K Buckard; K Kuroda; D Ortmann; K Munk; C Scholtissek; Hans-Joachim Schnittler; Detlev Drenckhahn; Hans-Dieter Klenk
Structure and assembly of hemagglutinin mutants of fowl plague virus with impaired surface transport.
Journal of virology 1992;66(3):1495-505.
1991: Reiko Ohuchi; Masanobu Ohuchi; Wolfgang Garten; Hans-Dieter Klenk
Human influenza virus hemagglutinin with high sensitivity to proteolytic activation.
Journal of virology 1991;65(7):3530-7.
1991: Wolfgang Garten; M Vey; Reiko Ohuchi; Masanobu Ohuchi; Hans-Dieter Klenk
Modification of the cleavage activation of the influenza virus hemagglutinin by site-specific mutagenesis.
Behring Institute Mitteilungen 1991;(89):12-22.
1991: Michael Veit; E Kretzschmar; K Kuroda; Wolfgang Garten; Michael F G Schmidt; Hans-Dieter Klenk; R Rott
Site-specific mutagenesis identifies three cysteine residues in the cytoplasmic tail as acylation sites of influenza virus hemagglutinin.
Journal of virology 1991;65(5):2491-500.
1990: K H Brücher; Wolfgang Garten; Hans-Dieter Klenk; E Shaw; Klaus Radsak
Inhibition of endoproteolytic cleavage of cytomegalovirus (HCMV) glycoprotein B by palmitoyl-peptidyl-chloromethyl ketone.
Virology 1990;178(2):617-20.
1990: E Pritzer; K Kuroda; Wolfgang Garten; Y Nagai; Hans-Dieter Klenk
A host range mutant of Newcastle disease virus with an altered cleavage site for proteolytic activation of the F protein.
Virus research 1990;15(3):237-42.
1989: Wolfgang Garten; A Stieneke; E Shaw; P Wikstrom; Hans-Dieter Klenk
Inhibition of proteolytic activation of influenza virus hemagglutinin by specific peptidyl chloroalkyl ketones.
Virology 1989;172(1):25-31.
1989: Masanobu Ohuchi; M Orlich; Reiko Ohuchi; B E Simpson; Wolfgang Garten; Hans-Dieter Klenk; R Rott
Mutations at the cleavage site of the hemagglutinin after the pathogenicity of influenza virus A/chick/Penn/83 (H5N2).
Virology 1989;168(2):274-80.
1988: Heinz Feldmann; E Kretzschmar; B Klingeborn; R Rott; Hans-Dieter Klenk; Wolfgang Garten
The structure of serotype H10 hemagglutinin of influenza A virus: comparison of an apathogenic avian and a mammalian strain pathogenic for mink.
Virology 1988;165(2):428-37.
1986: W Schuy; Cindy L Will; K Kuroda; C Scholtissek; Wolfgang Garten; Hans-Dieter Klenk
Mutations blocking the transport of the influenza virus hemagglutinin between the rough endoplasmic reticulum and the Golgi apparatus.
The EMBO journal 1986;5(11):2831-6.
1985: Wolfgang Garten; K Kuroda; W Schuy; H Naruse; C Scholtissek; Hans-Dieter Klenk
Haemagglutinin transport mutants.
Vaccine 1985;3(3 Suppl):227-9.
1984: W Schuy; Wolfgang Garten; D Linder; Hans-Dieter Klenk
The carboxyterminus of the hemagglutinin-neuraminidase of Newcastle disease virus is exposed at the surface of the viral envelope.
Virus research 1984;1(5):415-26.