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John Garthwaite

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
29
Garthwaite, Giti
10
Bellamy, Tomas
8
Batchelor, Andrew
7
Goodwin, David
6
Griffiths, Charmaine
5
Keynes, Robert
4
Morris, Richard
4
Bon, Christelle
4
Wykes, Victoria
4
Roy, Brijesh
3
Hajós, Ferenc
3
Neale, SA
3
Riddall, Dieter
3
Lancaster, Barrie
2
Gibb, Barry

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Publications

TOP 3
James L R; Griffiths C H; Garthwaite J; Bellamy T C
Inhibition of nitric oxide-activated guanylyl cyclase by calmodulin antagonists.
Halvey Edward J; Vernon Jeffrey; Roy Brijesh; Garthwaite John
Mechanisms of activity-dependent plasticity in cellular nitric oxide-cGMP signaling.
Hall Catherine N; Garthwaite John
What is the real physiological NO concentration in vivo?

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All Publications

2009: James L R; Griffiths C H; Garthwaite J; Bellamy T C
Inhibition of nitric oxide-activated guanylyl cyclase by calmodulin antagonists.
British journal of pharmacology 2009;158(6):1454-64.
2009: Halvey Edward J; Vernon Jeffrey; Roy Brijesh; Garthwaite John
Mechanisms of activity-dependent plasticity in cellular nitric oxide-cGMP signaling.
The Journal of biological chemistry 2009;284(38):25630-41.
2009: Hall Catherine N; Garthwaite John
What is the real physiological NO concentration in vivo?
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2009;21(2):92-103.
2009: Clutterbuck Lisa A; Posada Cristina Garcia; Visintin Cristina; Riddall Dieter R; Lancaster Barrie; Gane Paul J; Garthwaite John; Selwood David L
Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones.
Journal of medicinal chemistry 2009;52(9):2694-707.
2009: Hall Catherine N; Keynes Robert G; Garthwaite John
Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain.
The Biochemical journal 2009;419(2):411-8.
2008: Roy Brijesh; Halvey Edward J; Garthwaite John
An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase.
The Journal of biological chemistry 2008;283(27):18841-51.
2008: Garthwaite John
Concepts of neural nitric oxide-mediated transmission.
The European journal of neuroscience 2008;27(11):2783-802.
2008: Roy B; Mo E; Vernon J; Garthwaite J
Probing the presence of the ligand-binding haem in cellular nitric oxide receptors.
British journal of pharmacology 2008;153(7):1495-504.
2007: Garthwaite John
Neuronal nitric oxide synthase and the serotonin transporter get harmonious.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):7739-40.
2006: Hall C N; Garthwaite J
Inactivation of nitric oxide by rat cerebellar slices.
The Journal of physiology 2006;577(Pt 2):549-67.
2006: Hopper Rachel A; Garthwaite John
Tonic and phasic nitric oxide signals in hippocampal long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(45):11513-21.
2006: Roy Brijesh; Garthwaite John
Nitric oxide activation of guanylyl cyclase in cells revisited.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):12185-90.
2006: Garthwaite Giti; Bartus Katalin; Malcolm Denise; Goodwin David; Kollb-Sielecka Marta; Dooldeniya Chaminda; Garthwaite John
Signaling from blood vessels to CNS axons through nitric oxide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(29):7730-40.
2006: Riddall Dieter R; Leach Michael J; Garthwaite John
A novel drug binding site on voltage-gated sodium channels in rat brain.
Molecular pharmacology 2006;69(1):278-87.
2005: Keynes Robert G; Griffiths Charmaine H; Hall Catherine; Garthwaite John
Nitric oxide consumption through lipid peroxidation in brain cell suspensions and homogenates.
The Biochemical journal 2005;387(Pt 3):685-94.
2005: Garthwaite G; Batchelor A M; Goodwin D A; Hewson A K; Leeming K; Ahmed Z; Cuzner M L; Garthwaite J
Pathological implications of iNOS expression in central white matter: an ex vivo study of optic nerves from rats with experimental allergic encephalomyelitis.
The European journal of neuroscience 2005;21(8):2127-35.
2005: Duport S; Garthwaite J
Pathological consequences of inducible nitric oxide synthase expression in hippocampal slice cultures.
Neuroscience 2005;135(4):1155-66.
2005: Garthwaite John
Dynamics of cellular NO-cGMP signaling.
Frontiers in bioscience : a journal and virtual library 2005;10():1868-80.
2004: Mo Elaine; Amin Hemisha; Bianco Isaac H; Garthwaite John
Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway.
The Journal of biological chemistry 2004;279(25):26149-58.
2004: Hopper Rachel; Lancaster Barrie; Garthwaite John
On the regulation of NMDA receptors by nitric oxide.
The European journal of neuroscience 2004;19(7):1675-82.
2004: Wykes Victoria; Garthwaite John
Membrane-association and the sensitivity of guanylyl cyclase-coupled receptors to nitric oxide.
British journal of pharmacology 2004;141(7):1087-90.
2004: Keynes Robert G; Garthwaite John
Nitric oxide and its role in ischaemic brain injury.
Current molecular medicine 2004;4(2):179-91.
2004: Keynes Robert G; Duport Sophie; Garthwaite John
Hippocampal neurons in organotypic slice culture are highly resistant to damage by endogenous and exogenous nitric oxide.
The European journal of neuroscience 2004;19(5):1163-73.
2003: Griffiths Charmaine; Wykes Victoria; Bellamy Tomas C; Garthwaite John
A new and simple method for delivering clamped nitric oxide concentrations in the physiological range: application to activation of guanylyl cyclase-coupled nitric oxide receptors.
Molecular pharmacology 2003;64(6):1349-56.
2003: Gibb Barry J; Wykes Victoria; Garthwaite John
Properties of NO-activated guanylyl cyclases expressed in cells.
British journal of pharmacology 2003;139(5):1032-40.
2003: Bon Christelle L M; Garthwaite John
On the role of nitric oxide in hippocampal long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(5):1941-8.
2003: Keynes Robert G; Griffiths Charmaine; Garthwaite John
Superoxide-dependent consumption of nitric oxide in biological media may confound in vitro experiments.
The Biochemical journal 2003;369(Pt 2):399-406.
2002: Wykes Victoria; Bellamy Tomas C; Garthwaite John
Kinetics of nitric oxide-cyclic GMP signalling in CNS cells and its possible regulation by cyclic GMP.
Journal of neurochemistry 2002;83(1):37-47.
2002: Bellamy Tomas C; Griffiths Charmaine; Garthwaite John
Differential sensitivity of guanylyl cyclase and mitochondrial respiration to nitric oxide measured using clamped concentrations.
The Journal of biological chemistry 2002;277(35):31801-7.
2002: Bellamy Tomas C; Garthwaite John
Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
British journal of pharmacology 2002;136(1):95-103.
2002: Bon Christelle L M; Garthwaite John
Adenosine acting on A1 receptors protects NO-triggered rebound potentiation and LTP in rat hippocampal slices.
Journal of neurophysiology 2002;87(4):1781-9.
2002: Griffiths Charmaine; Garthwaite Giti; Goodwin David A; Garthwaite John
Dynamics of nitric oxide during simulated ischaemia-reperfusion in rat striatal slices measured using an intrinsic biosensor, soluble guanylyl cyclase.
The European journal of neuroscience 2002;15(6):962-8.
2002: Griffiths Charmaine; Yamini Bakhtiar; Hall Catherine; Garthwaite John
Nitric oxide inactivation in brain by a novel O2-dependent mechanism resulting in the formation of nitrate ions.
The Biochemical journal 2002;362(Pt 2):459-64.
2002: Bellamy Tomas C; Garthwaite John
The receptor-like properties of nitric oxide-activated soluble guanylyl cyclase in intact cells.
Molecular and cellular biochemistry 2002;230(1-2):165-76.
2002: Bellamy Tomas C; Wood John; Garthwaite John
On the activation of soluble guanylyl cyclase by nitric oxide.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):507-10.
2002: Garthwaite G; Goodwin D A; Neale S; Riddall D; Garthwaite J
Soluble guanylyl cyclase activator YC-1 protects white matter axons from nitric oxide toxicity and metabolic stress, probably through Na(+) channel inhibition.
Molecular pharmacology 2002;61(1):97-104.
2002: Garthwaite G; Goodwin D A; Batchelor A M; Leeming K; Garthwaite J
Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve.
Neuroscience 2002;109(1):145-55.
2001: Griffiths C; Garthwaite J
The shaping of nitric oxide signals by a cellular sink.
The Journal of physiology 2001;536(Pt 3):855-62.
2001: Neale S A; Garthwaite J; Batchelor A M
mGlu1 receptors mediate a post-tetanic depression at parallel fibre-Purkinje cell synapses in rat cerebellum.
The European journal of neuroscience 2001;14(8):1313-9.
2001: Bon C L; Garthwaite J
Exogenous nitric oxide causes potentiation of hippocampal synaptic transmission during low-frequency stimulation via the endogenous nitric oxide-cGMP pathway.
The European journal of neuroscience 2001;14(4):585-94.
2001: Neale S A; Garthwaite J; Batchelor A M
Metabotropic glutamate receptor subtypes modulating neurotransmission at parallel fibre-Purkinje cell synapses in rat cerebellum.
Neuropharmacology 2001;41(1):42-9.
2001: Bon C L; Garthwaite J
Nitric oxide-induced potentiation of CA1 hippocampal synaptic transmission during baseline stimulation is strictly frequency-dependent.
Neuropharmacology 2001;40(4):501-7.
2001: Gibb B J; Garthwaite J
Subunits of the nitric oxide receptor, soluble guanylyl cyclase, expressed in rat brain.
The European journal of neuroscience 2001;13(3):539-44.
2001: Bellamy T C; Garthwaite J
Sub-second kinetics of the nitric oxide receptor, soluble guanylyl cyclase, in intact cerebellar cells.
The Journal of biological chemistry 2001;276(6):4287-92.
2001: Bellamy T C; Garthwaite J
"cAMP-specific" phosphodiesterase contributes to cGMP degradation in cerebellar cells exposed to nitric oxide.
Molecular pharmacology 2001;59(1):54-61.
2000: Bellamy T C; Wood J; Goodwin D A; Garthwaite J
Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2928-33.
1999: Strijbos P J; Pratt G D; Khan S; Charles I G; Garthwaite J
Molecular characterization and in situ localization of a full-length cyclic nucleotide-gated channel in rat brain.
The European journal of neuroscience 1999;11(12):4463-7.
1999: Garthwaite G; Goodwin D A; Garthwaite J
Nitric oxide stimulates cGMP formation in rat optic nerve axons, providing a specific marker of axon viability.
The European journal of neuroscience 1999;11(12):4367-72.
1999: Vetter P; Garthwaite J; Batchelor A M
Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors.
Neuropharmacology 1999;38(6):805-15.
1999: Garthwaite G; Brown G; Batchelor A M; Goodwin D A; Garthwaite J
Mechanisms of ischaemic damage to central white matter axons: a quantitative histological analysis using rat optic nerve.
Neuroscience 1999;94(4):1219-30.
1997: Batchelor A M; Knöpfel T; Gasparini F; Garthwaite J
Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices.
Neuropharmacology 1997;36(3):401-3.
1997: Batchelor A M; Garthwaite J
Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway.
Nature 1997;385(6611):74-7.
1996: Boxall A R; Garthwaite J
Long-term depression in rat cerebellum requires both NO synthase and NO-sensitive guanylyl cyclase.
The European journal of neuroscience 1996;8(10):2209-12.
1996: Southam E; Charles S L; Garthwaite J
The nitric oxide-cyclic GMP pathway and synaptic plasticity in the rat superior cervical ganglion.
British journal of pharmacology 1996;119(3):527-32.
1996: Xie X M; Garthwaite J
State-dependent inhibition of Na+ currents by the neuroprotective agent 619C89 in rat hippocampal neurons and in a mammalian cell line expressing rat brain type IIA Na+ channels.
Neuroscience 1996;73(4):951-62.
1996: Salter M; Strijbos P J; Neale S; Duffy C; Follenfant R L; Garthwaite J
The nitric oxide-cyclic GMP pathway is required for nociceptive signalling at specific loci within the somatosensory pathway.
Neuroscience 1996;73(3):649-55.
1996: Strijbos P J; Leach M J; Garthwaite J
Vicious cycle involving Na+ channels, glutamate release, and NMDA receptors mediates delayed neurodegeneration through nitric oxide formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(16):5004-13.
1996: Salter M; Duffy C; Garthwaite J; Strijbos P J
Ex vivo measurement of brain tissue nitrite and nitrate accurately reflects nitric oxide synthase activity in vivo.
Journal of neurochemistry 1996;66(4):1683-90.
1996: Boxall A R; Lancaster B; Garthwaite J
Tyrosine kinase is required for long-term depression in the cerebellum.
Neuron 1996;16(4):805-13.
1996: Garthwaite J; Batchelor A M
A biplanar slice preparation for studying cerebellar synaptic transmission.
Journal of neuroscience methods 1996;64(2):189-97.
1995: Boulton C L; Southam E; Garthwaite J
Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase.
Neuroscience 1995;69(3):699-703.
1995: Garthwaite J; Southam E; Boulton C L; Nielsen E B; Schmidt K; Mayer B
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Molecular pharmacology 1995;48(2):184-8.
1995: Salter M; Duffy C; Garthwaite J; Strijbos P J
Substantial regional and hemispheric differences in brain nitric oxide synthase (NOS) inhibition following intracerebroventricular administration of N omega-nitro-L-arginine (L-NA) and its methyl ester (L-NAME).
Neuropharmacology 1995;34(6):639-49.
1995: Boxall A R; Garthwaite J
Synaptic excitation mediated by AMPA receptors in rat cerebellar slices is selectively enhanced by aniracetam and cyclothiazide.
Neurochemical research 1995;20(5):605-9.
1995: Garthwaite J
Neural nitric oxide signalling.
Trends in neurosciences 1995;18(2):51-2.
1995: Garthwaite J; Boulton C L
Nitric oxide signaling in the central nervous system.
Annual review of physiology 1995;57():683-706.
1994: Batchelor A M; Madge D J; Garthwaite J
Synaptic activation of metabotropic glutamate receptors in the parallel fibre-Purkinje cell pathway in rat cerebellar slices.
Neuroscience 1994;63(4):911-5.
1994: Garthwaite G; Garthwaite J
Nitric oxide does not mediate acute glutamate neurotoxicity, nor is it neuroprotective, in rat brain slices.
Neuropharmacology 1994;33(11):1431-8.
1994: Boulton C L; Irving A J; Southam E; Potier B; Garthwaite J; Collingridge G L
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices.
The European journal of neuroscience 1994;6(10):1528-35.
1994: Morris R; Southam E; Gittins S R; de Vente J; Garthwaite J
The NO-cGMP pathway in neonatal rat dorsal horn.
The European journal of neuroscience 1994;6(5):876-9.
1993: Southam E; Garthwaite J
The nitric oxide-cyclic GMP signalling pathway in rat brain.
Neuropharmacology 1993;32(11):1267-77.
1993: Morris R; Southam E; Gittins S R; Garthwaite J
NADPH-diaphorase staining in autonomic and somatic cranial ganglia of the rat.
Neuroreport 1993;4(1):62-4.
1993: Batchelor A M; Garthwaite J
Novel synaptic potentials in cerebellar Purkinje cells: probable mediation by metabotropic glutamate receptors.
Neuropharmacology 1993;32(1):11-20.
1992: East S J; Garthwaite J
Actions of a metabotropic glutamate receptor agonist in immature and adult rat cerebellum.
European journal of pharmacology 1992;219(3):395-400.
1992: Morris R; Southam E; Braid D J; Garthwaite J
Nitric oxide may act as a messenger between dorsal root ganglion neurones and their satellite cells.
Neuroscience letters 1992;137(1):29-32.
1992: Southam E; Morris R; Garthwaite J
Sources and targets of nitric oxide in rat cerebellum.
Neuroscience letters 1992;137(2):241-4.
1992: Garthwaite G; Hajos F; Garthwaite J
Morphological response of endoplasmic reticulum in cerebellar Purkinje cells to calcium deprivation.
Neuroscience 1992;48(3):681-8.
1991: East S J; Batchelor A M; Garthwaite J
Selective blockade of N-methyl-D-aspartate receptor function by the nitric oxide donor, nitroprusside.
European journal of pharmacology 1991;209(1-2):119-21.
1991: Southam E; Garthwaite J
Intercellular action of nitric oxide in adult rat cerebellar slices.
Neuroreport 1991;2(11):658-60.
1991: Southam E; Garthwaite J
Comparative effects of some nitric oxide donors on cyclic GMP levels in rat cerebellar slices.
Neuroscience letters 1991;130(1):107-11.
1991: Southam E; East S J; Garthwaite J
Excitatory amino acid receptors coupled to the nitric oxide/cyclic GMP pathway in rat cerebellum during development.
Journal of neurochemistry 1991;56(6):2072-81.
1991: Garthwaite J
Glutamate, nitric oxide and cell-cell signalling in the nervous system.
Trends in neurosciences 1991;14(2):60-7.
1991: East S J; Garthwaite J
NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway.
Neuroscience letters 1991;123(1):17-9.
1990: D'Angelo E; Rossi P; Garthwaite J
Dual-component NMDA receptor currents at a single central synapse.
Nature 1990;346(6283):467-70.
1990: East S J; Garthwaite J
Nanomolar N(G)-nitroarginine inhibits NMDA-induced cyclic GMP formation in rat cerebellum.
European journal of pharmacology 1990;184(2-3):311-3.
1990: Garthwaite J; Garthwaite G
Mechanisms of excitatory amino acid neurotoxicity in rat brain slices.
Advances in experimental medicine and biology 1990;268():505-18.
1989: Garthwaite J; Beaumont P S
Excitatory amino acid receptors in the parallel fibre pathway in rat cerebellar slices.
Neuroscience letters 1989;107(1-3):151-6.
1989: Garthwaite J; Southam E; Anderton M
A kainate receptor linked to nitric oxide synthesis from arginine.
Journal of neurochemistry 1989;53(6):1952-4.
1989: Garthwaite J; Garthwaite G; Palmer R M; Moncada S
NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices.
European journal of pharmacology 1989;172(4-5):413-6.
1989: Garthwaite G; Garthwaite J
Neurotoxicity of excitatory amino acid receptor agonists in young rat hippocampal slices.
Journal of neuroscience methods 1989;29(1):33-42.
1989: Garthwaite G; Garthwaite J
Quisqualate neurotoxicity: a delayed, CNQX-sensitive process triggered by a CNQX-insensitive mechanism in young rat hippocampal slices.
Neuroscience letters 1989;99(1-2):113-8.
1989: Garthwaite G; Garthwaite J
Differential dependence on Ca2+ of N-methyl-D-aspartate and quisqualate neurotoxicity in young rat hippocampal slices.
Neuroscience letters 1989;97(3):316-22.
1989: Garthwaite J; Brodbelt A R
Synaptic activation of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the mossy fibre pathway in adult and immature rat cerebellar slices.
Neuroscience 1989;29(2):401-12.
1988: Garthwaite J; Charles S L; Chess-Williams R
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain.
Nature 1988;336(6197):385-8.
1988: Garthwaite G; Garthwaite J
Cyclic GMP and cell death in rat cerebellar slices.
Neuroscience 1988;26(1):321-6.
1988: Garthwaite G; Garthwaite J
Electron microscopic autoradiography of D-[3H]aspartate uptake sites in mouse cerebellar slices shows poor labelling of mossy fibre terminals.
Brain research 1988;440(1):162-6.
1987: Garthwaite G; Yamini B; Garthwaite J
Selective loss of Purkinje and granule cell responsiveness to N-methyl-D-aspartate in rat cerebellum during development.
Brain research 1987;433(2):288-92.
1987: Garthwaite G; Garthwaite J
Receptor-linked ionic channels mediate N-methyl-D-aspartate neurotoxicity in rat cerebellar slices.
Neuroscience letters 1987;83(3):241-6.
1987: Garthwaite G; Garthwaite J
Quinolinate mimics neurotoxic actions of N-methyl-D-aspartate in rat cerebellar slices.
Neuroscience letters 1987;79(1-2):35-9.
1987: Garthwaite J; Garthwaite G
Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro.
Journal of neurochemistry 1987;48(1):29-39.
1986: Garthwaite G; Garthwaite J
Amino acid neurotoxicity: intracellular sites of calcium accumulation associated with the onset of irreversible damage to rat cerebellar neurones in vitro.
Neuroscience letters 1986;71(1):53-8.
1986: Garthwaite J; Garthwaite G; Hajós F
Amino acid neurotoxicity: relationship to neuronal depolarization in rat cerebellar slices.
Neuroscience 1986;18(2):449-60.
1986: Garthwaite G; Hajós F; Garthwaite J
Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices.
Neuroscience 1986;18(2):437-47.
1986: Hajós F; Garthwaite G; Garthwaite J
Reversible and irreversible neuronal damage caused by excitatory amino acid analogues in rat cerebellar slices.
Neuroscience 1986;18(2):417-36.
1986: Garthwaite G; Garthwaite J
Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on calcium concentration.
Neuroscience letters 1986;66(2):193-8.
1986: Garthwaite G; Garthwaite J
In vitro neurotoxicity of excitatory acid analogues during cerebellar development.
Neuroscience 1986;17(3):755-67.
1985: Garthwaite G; Garthwaite J
Sites of D-[3H]aspartate accumulation in mouse cerebellar slices.
Brain research 1985;343(1):129-36.
1984: Garthwaite G; Garthwaite J
Differential sensitivity of rat cerebellar cells in vitro to the neurotoxic effects of excitatory amino acid analogues.
Neuroscience letters 1984;48(3):361-7.
1983: Garthwaite J; Garthwaite G
The mechanism of kainic acid neurotoxicity.
Nature 1983;305(5930):138-40.

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