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Javier Garzón

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Pilar Sánchez-Blázquez; María Rodríguez-Muñoz; Concha Bailón; Javier Garzón
GPCRs promote the release of zinc ions mediated by nNOS/NO and the redox transducer RGSZ2 protein.
Javier Garzón; María Rodríguez-Muñoz; Pilar Sánchez-Blázquez
Direct association of Mu-opioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance.
María Rodríguez-Muñoz; Pilar Sánchez-Blázquez; Ana Vicente-Sánchez; Concha Bailón; Beatriz Martín-Aznar; Javier Garzón
The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation.

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All Publications

2012: Pilar Sánchez-Blázquez; María Rodríguez-Muñoz; Concha Bailón; Javier Garzón
GPCRs promote the release of zinc ions mediated by nNOS/NO and the redox transducer RGSZ2 protein.
Antioxidants & redox signaling 2012;17(9):1163-77.
2012: Javier Garzón; María Rodríguez-Muñoz; Pilar Sánchez-Blázquez
Direct association of Mu-opioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance.
Current drug abuse reviews 2012;5(3):199-226.
2011: María Rodríguez-Muñoz; Pilar Sánchez-Blázquez; Ana Vicente-Sánchez; Concha Bailón; Beatriz Martín-Aznar; Javier Garzón
The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation.
Cellular and molecular life sciences : CMLS 2011;68(17):2933-49.
2011: Javier Garzón; Ricardo Martínez-Murillo; María Rodríguez-Muñoz; Concha Bailón; Ana Vicente-Sánchez; Pilar Sánchez-Blázquez
RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway.
Antioxidants & redox signaling 2011;15(4):873-87.
2011: María Rodríguez-Muñoz; Elena de la Torre-Madrid; Pilar Sánchez-Blázquez; Javier Garzón
NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.
Antioxidants & redox signaling 2011;14(12):2413-25.
2009: Pilar Sánchez-Blázquez; María Rodríguez-Muñoz; Elena de la Torre-Madrid; Javier Garzón
Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway.
Cellular signalling 2009;21(9):1444-54.
2009: Javier Garzón; Elena de la Torre-Madrid; María Rodríguez-Muñoz; Ana Vicente-Sánchez; Pilar Sánchez-Blázquez
Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.
Molecular pain 2009;5():11.
2008: Javier Garzón; María Rodríguez-Muñoz; Pilar Sánchez-Blázquez
Do pharmacological approaches that prevent opioid tolerance target different elements in the same regulatory machinery?
Current drug abuse reviews 2008;1(2):222-38.
2008: Pilar Sánchez-Blázquez; María Rodríguez-Muñoz; Carlos Montero; Elena de la Torre-Madrid; Javier Garzón
Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein.
Neuropharmacology 2008;54(2):319-30.
2007: María Rodríguez-Muñoz; Elena de la Torre-Madrid; Gema Gaitán; Pilar Sánchez-Blázquez; Javier Garzón
RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons.
Cellular signalling 2007;19(12):2558-71.
2007: María Rodríguez-Muñoz; David Bermúdez; Pilar Sánchez-Blázquez; Javier Garzón
Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(4):842-50.
2007: María Rodríguez-Muñoz; Elena de la Torre-Madrid; Pilar Sánchez-Blázquez; Javier Garzón
Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins.
Molecular pain 2007;3():19.
2005: Javier Garzón; María Rodríguez-Muñoz; Almudena López-Fando; Pilar Sánchez-Blázquez
The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(9):1632-48.
2005: Javier Garzón; María Rodríguez-Muñoz; Elena de la Torre-Madrid; Pilar Sánchez-Blázquez
Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS.
Psychopharmacology 2005;180(1):1-11.
2005: Javier Garzón; María Rodríguez-Muñoz; Pilar Sánchez-Blázquez
Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter.
Neuropharmacology 2005;48(6):853-68.
2005: Javier Garzón; María Rodríguez-Muñoz; Almudena López-Fando; Pilar Sánchez-Blázquez
Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization.
The Journal of biological chemistry 2005;280(10):8951-60.
2005: Pilar Sánchez-Blázquez; María Rodríguez-Muñoz; Carlos Montero; Javier Garzón
RGS-Rz and RGS9-2 proteins control mu-opioid receptor desensitisation in CNS: the role of activated Galphaz subunits.
Neuropharmacology 2005;48(1):134-50.
2005: Almudena López-Fando; María Rodríguez-Muñoz; Pilar Sánchez-Blázquez; Javier Garzón
Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(1):99-110.
2004: Javier Garzón; María Rodríguez-Muñoz; Almudena López-Fando; Antonio García-España; Pilar Sánchez-Blázquez
RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(6):1091-104.
2003: Javier Garzón; Almudena López-Fando; Pilar Sánchez-Blázquez
The R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(11):1983-90.
2003: Pilar Sánchez-Blázquez; Marta Rodríguez-Díaz; Almudena López-Fando; María Rodríguez-Muñoz; Javier Garzón
The GBeta5 subunit that associates with the R7 subfamily of RGS proteins regulates mu-opioid effects.
Neuropharmacology 2003;45(1):82-95.
2003: Pilar Sánchez-Blázquez; Isabel De Antonio; Carlos Montero; Javier Garzón
Exogenous myristoylated-G(i2)alpha subunits of GTP-binding proteins are mitogens following their internalization by astrocytes in culture.
Brain research. Molecular brain research 2003;110(1):15-26.
2002: Javier Garzón; Marta Rodríguez-Díaz; Almudena López-Fando; Antonio García-España; Pilar Sánchez-Blázquez
Glycosylated phosducin-like protein long regulates opioid receptor function in mouse brain.
Neuropharmacology 2002;42(6):813-28.
2001: Javier Garzón; Pilar Sánchez-Blázquez
Administration of myr(+)-G(i2)alpha subunits prevents acute tolerance (tachyphylaxis) to mu-opioid effects in mice.
Neuropharmacology 2001;40(4):560-9.
2001: Javier Garzón; Marta Rodríguez-Díaz; Almudena López-Fando; Pilar Sánchez-Blázquez
RGS9 proteins facilitate acute tolerance to mu-opioid effects.
The European journal of neuroscience 2001;13(4):801-11.
2001: Pilar Sánchez-Blázquez; P Gómez-Serranillos; Javier Garzón
Agonists determine the pattern of G-protein activation in mu-opioid receptor-mediated supraspinal analgesia.
Brain research bulletin 2001;54(2):229-35.
2001: D M Hutcheson; H W D Matthes; Emmanuel Valjent; Pilar Sánchez-Blázquez; Marta Rodríguez-Díaz; Javier Garzón; Jerome Becker; Rafael Maldonado
Lack of dependence and rewarding effects of deltorphin II in mu-opioid receptor-deficient mice.
The European journal of neuroscience 2001;13(1):153-61.
2000: Pilar Sánchez-Blázquez; MA Boronat; Gabriel Olmos; Jesús A García-Sevilla; Javier Garzón
Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
British journal of pharmacology 2000;130(1):146-52.
2000: Javier Garzón; I de Antonio; Pilar Sánchez-Blázquez
In vivo modulation of G proteins and opioid receptor function by antisense oligodeoxynucleotides.
Methods in enzymology 2000;314():3-20.
1999: Javier Garzón; Marta Rodríguez-Díaz; I DeAntonio; Javier DeFelipe; J R Rodríguez; Pilar Sánchez-Blázquez
Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice.
Neuropharmacology 1999;38(12):1861-73.
1999: Pilar Sánchez-Blázquez; Marta Rodríguez-Díaz; I DeAntonio; Javier Garzón
Endomorphin-1 and endomorphin-2 show differences in their activation of mu opioid receptor-regulated G proteins in supraspinal antinociception in mice.
The Journal of pharmacology and experimental therapeutics 1999;291(1):12-8.
1999: Pilar Sánchez-Blázquez; I DeAntoio; Marta Rodríguez-Díaz; Javier Garzón
Antisense oligodeoxynucleotide targeting distinct exons of the cloned mu-opioid receptor distinguish between endomorphin-1 and morphine supraspinal antinociception in mice.
Antisense & nucleic acid drug development 1999;9(3):253-60.
1999: Pilar Sánchez-Blázquez; Marta Rodríguez-Díaz; M T Frejo; Javier Garzón
Stimulation of mu- and delta-opioid receptors enhances phosphoinositide metabolism in mouse spinal cord: evidence for subtypes of delta-receptors.
The European journal of neuroscience 1999;11(6):2059-64.
1999: Olga Pol; L Valle; Pilar Sánchez-Blázquez; Javier Garzón; Margarita M Puig
Antibodies and antisense oligodeoxynucleotides to mu-opioid receptors, selectively block the effects of mu-opioid agonists on intestinal transit and permeability in mice.
British journal of pharmacology 1999;127(2):397-404.
1999: Javier Garzón; Javier DeFelipe; J R Rodríguez; I DeAntonio; Antonio García-España; Pilar Sánchez-Blázquez
Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity.
Brain research. Molecular brain research 1999;65(2):151-66.
1998: Javier Garzón; Marian Castro; Pilar Sánchez-Blázquez
Influence of Gz and Gi2 transducer proteins in the affinity of opioid agonists to mu receptors.
The European journal of neuroscience 1998;10(8):2557-64.
1998: Pilar Sánchez-Blázquez; Javier Garzón
delta Opioid receptor subtypes activate inositol-signaling pathways in the production of antinociception.
The Journal of pharmacology and experimental therapeutics 1998;285(2):820-7.
1998: Javier DeFelipe; P Marco; R G Sola; Pilar Sánchez-Blázquez; Javier Garzón
Local changes in GTP-binding protein immunoreactivities in human epileptogenic neocortex.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1998;119(2):153-8.
1998: Marta Rodríguez-Díaz; Javier Garzón; Pilar Sánchez-Blázquez
The delta2-opioid receptor subtype stimulates phosphoinositide metabolism in mouse periaqueductal gray matter.
Life sciences 1998;62(16):PL253-8.
1997: Javier Garzón; Y Martínez-Peña; P Sanchez-Blázquez
Gx/z is regulated by mu but not delta opioid receptors in the stimulation of the low Km GTPase activity in mouse periaqueductal grey matter.
The European journal of neuroscience 1997;9(6):1194-200.
1997: Javier Garzón; Antonio García-España; Pilar Sánchez-Blázquez
Opioids binding mu and delta receptors exhibit diverse efficacy in the activation of Gi2 and G(x/z) transducer proteins in mouse periaqueductal gray matter.
The Journal of pharmacology and experimental therapeutics 1997;281(1):549-57.
1997: Pilar Sánchez-Blázquez; A García-Espãna; Javier Garzón
Antisense oligodeoxynucleotides to opioid mu and delta receptors reduced morphine dependence in mice: role of delta-2 opioid receptors.
The Journal of pharmacology and experimental therapeutics 1997;280(3):1423-31.
1996: Pilar Sánchez-Blázquez; M D Rodríguez; Javier Garzón
Antibodies directed against the mu-opioid receptor alleviated multiple signs of morphine withdrawal in mice.
Life sciences 1996;59(8):PL87-92.
1995: Pilar Sánchez-Blázquez; Antonio García-España; Javier Garzón
In vivo injection of antisense oligodeoxynucleotides to G alpha subunits and supraspinal analgesia evoked by mu and delta opioid agonists.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1590-6.
1995: Pilar Sánchez-Blázquez; Javier Garzón
alpha N-acetyl-beta-endorphin-(1-31) disrupts the diminishing effect of mastoparan on opioid- and clonidine-evoked supraspinal antinociception in mice.
The Journal of pharmacology and experimental therapeutics 1995;273(2):787-92.
1995: Y Martínez-Peña; Pilar Sánchez-Blázquez; Javier Garzón
G-receptor antagonists increased the activating effect of mastoparan on low Km GTPase of mouse PAG.
Cellular signalling 1995;7(2):151-5.
1994: Javier Garzón; Marian Castro; J L Juarros; Pilar Sánchez-Blázquez
Antibodies raised against the N-terminal sequence of delta opioid receptors blocked delta-mediated supraspinal antinociception in mice.
Life sciences 1994;54(11):PL191-6.
1994: Pilar Sánchez-Blázquez; Javier Garzón
Antibodies directed against alpha subunits of Gi, Gx/z, GO and GS transducer proteins reduced the morphine withdrawal syndrome in mice.
Life sciences 1994;55(23):PL445-50.
1994: Javier Garzón; Y Martínez-Peña; Pilar Sánchez-Blázquez
Dissimilar efficacy of opioids to produce mu-mediated analgesia: role of Gx/z and Gi2 transducer proteins.
Life sciences 1994;55(11):PL205-12.
1993: Y Martínez-Peña; Javier Garzón
Distribution of low Km GTPase activity in mouse CNS: effect of chronic morphine.
Life sciences 1993;52(16):PL123-8.
1993: Pilar Sánchez-Blázquez; Javier Garzón
Delta-opioid supraspinal antinociception in mice is mediated by Gi3 transducer proteins.
Life sciences 1993;53(7):PL129-34.
1993: Pilar Sánchez-Blázquez; J L Juarros; Y Martínez-Peña; Marian Castro; Javier Garzón
Gx/z and Gi2 transducer proteins on mu/delta opioid-mediated supraspinal antinociception.
Life sciences 1993;53(23):PL381-6.
1990: M Lérida; Javier Garzón; P Sánchez-Blázquez
Intrathecal pertussis toxin attenuates the morphine withdrawal syndrome in normal but not in arthritic rats.
Life sciences 1990;46(5):329-34.
1990: Javier Garzón; M Lérida; P Sánchez-Blázquez
Effect of intrathecal injection of pertussis toxin on substance P, norepinephrine and serotonin contents in various neural structures of arthritic rats.
Life sciences 1990;47(21):1915-23.
1990: Javier Garzón; M Lérida; I Ulibarri; P Sánchez-Blázquez
Effect of ICV pertussis toxin and N-ethylmaleimide on the levels of substance P and serotonin in brain and spinal cord of the rat.
Life sciences 1990;46(17):1217-22.
1989: P Sánchez-Blázquez; I Ulibarri; Javier Garzón
Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.
European journal of pharmacology 1989;166(2):193-200.
1989: P Sánchez-Blázquez; Javier Garzón
Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect.
European journal of pharmacology 1989;159(1):9-23.
1988: P Sánchez-Blázquez; Javier Garzón
Pertussis toxin differentially reduces the efficacy of opioids to produce supraspinal analgesia in the mouse.
European journal of pharmacology 1988;152(3):357-61.
1987: M Lérida; P Sánchez-Blázquez; Javier Garzón
Incidence of morphine withdrawal and quasi-abstinence syndrome in a model of chronic pain in the rat.
Neuroscience letters 1987;81(1-2):155-8.
1986: P Sánchez-Blázquez; Javier Garzón
Opioid analgesia in the mouse: evidence for multiple receptors using beta-FNA.
NIDA research monograph 1986;75():465-8.
1986: Javier Garzón; P Sánchez-Blázquez
A single icv injection of KCl induces a selective and long-lasting inhibition of opioid analgesia in mice.
NIDA research monograph 1986;75():450-3.