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Don Gash

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O M Littrell; Francois Pomerleau; A D Richardson; Jadwiga Turchan-Cholewo; Luke Bradley; J L Fuqua; Don M Gash; Erin Hascup; Peter Huettl; Greg A Gerhardt
A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function.
David K Stiles; Lubomir Tchangov; Zhiming Zhang; Gregory R Stewart; Yi Ai; Mark T Butt; Klaus Charisse; Don M Gash; Pei Ge; Richard Grondin; Andrei P Guzaev; Douglas Gwost; Peter Hardy; William F Kaemmerer; Verbena Kosovrasti; Martin Maier; Muthiah Manoharan; Michael Meys; Lubomir Nechev; Brian Nelson; Peter T Nelson; Dinah W Y Sah
Widespread suppression of huntingtin with convection-enhanced delivery of siRNA.
Kristen A Kelps; Jadwiga Turchan-Cholewo; Erin Hascup; Tiffany L Taylor; Don M Gash; Greg A Gerhardt; Luke Bradley
Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence.

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2013: O M Littrell; Francois Pomerleau; A D Richardson; Jadwiga Turchan-Cholewo; Luke Bradley; J L Fuqua; Don M Gash; Erin Hascup; Peter Huettl; Greg A Gerhardt
A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function.
Neuropeptides 2013;47(1):43-9.
2012: David K Stiles; Lubomir Tchangov; Zhiming Zhang; Gregory R Stewart; Yi Ai; Mark T Butt; Klaus Charisse; Don M Gash; Pei Ge; Richard Grondin; Andrei P Guzaev; Douglas Gwost; Peter Hardy; William F Kaemmerer; Verbena Kosovrasti; Martin Maier; Muthiah Manoharan; Michael Meys; Lubomir Nechev; Brian Nelson; Peter T Nelson; Dinah W Y Sah
Widespread suppression of huntingtin with convection-enhanced delivery of siRNA.
Experimental neurology 2012;233(1):463-71.
2011: Kristen A Kelps; Jadwiga Turchan-Cholewo; Erin Hascup; Tiffany L Taylor; Don M Gash; Greg A Gerhardt; Luke Bradley
Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence.
Neuropeptides 2011;45(3):213-8.
2010: Mei Liu; Dong-Young Choi; Randy L Hunter; Jignesh D Pandya; Wayne A Cass; Patrick G Sullivan; Hyoung-Chun Kim; Don M Gash; Guoying Bing
Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.
Journal of neurochemistry 2010;112(3):773-83.
2010: Luke Bradley; Josh Fuqua; April Richardson; Jadwiga Turchan-Cholewo; Yi Ai; Kristen A Kelps; John D Glass; Xiuquan He; Zhiming Zhang; Richard Grondin; O Meagan Littrell; Peter Huettl; Francois Pomerleau; Don M Gash; Greg A Gerhardt
Dopamine neuron stimulating actions of a GDNF propeptide.
PloS one 2010;5(3):e9752.
2009: Dong-Young Choi; Mei Liu; Randy L Hunter; Wayne A Cass; Jignesh D Pandya; Patrick G Sullivan; Eun-Joo Shin; Hyoung-Chun Kim; Don M Gash; Guoying Bing
Striatal neuroinflammation promotes Parkinsonism in rats.
PloS one 2009;4(5):e5482.
2008: Feng Ding; Liming Luan; Yi Ai; Ashley Walton; Greg A Gerhardt; Don M Gash; Richard Grondin; Zhiming Zhang
Development of a stable, early stage unilateral model of Parkinson's disease in middle-aged rhesus monkeys.
Experimental neurology 2008;212(2):431-9.
2008: Don M Gash; Kathryn Rutland; Naomi L Hudson; Patrick G Sullivan; Guoying Bing; Wayne A Cass; Jignesh D Pandya; Mei Liu; Dong-Yong Choi; Randy L Hunter; Greg A Gerhardt; Charlie D Smith; John T Slevin; TS Prince
Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity.
Annals of neurology 2008;63(2):184-92.
2008: Liming Luan; Feng Ding; Yi Ai; Anders Andersen; Peter Hardy; Eric Forman; Greg A Gerhardt; Don M Gash; Richard Grondin; Zhiming Zhang
Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus monkeys.
Cell transplantation 2008;17(4):417-25.
2008: Richard Grondin; Zhiming Zhang; Yi Ai; F Ding; A A Walton; Stewart P Surgener; Greg A Gerhardt; Don M Gash
Intraputamenal infusion of exogenous neurturin protein restores motor and dopaminergic function in the globus pallidus of MPTP-lesioned rhesus monkeys.
Cell transplantation 2008;17(4):373-81.
2007: Jorge E Quintero; Brian K Day; Zhiming Zhang; Richard Grondin; Michelle L Stephens; Peter Huettl; Francois Pomerleau; Don M Gash; Greg A Gerhardt
Amperometric measures of age-related changes in glutamate regulation in the cortex of rhesus monkeys.
Experimental neurology 2007;208(2):238-46.
2007: Randy L Hunter; Dong-Young Choi; Jeanie F Kincer; Wayne A Cass; Guoying Bing; Don M Gash
Fenbendazole treatment may influence lipopolysaccharide effects in rat brain.
Comparative medicine 2007;57(5):487-92.
2007: Charles D Smith; Ashley Walton; John T Slevin; Greg A Gerhardt; Gloria Umberger; Kyle Smoot; Emily Schulze; Don M Gash
Validation studies of the human movement analysis panel for hand/arm performance.
Journal of neuroscience methods 2007;165(2):287-96.
2007: David N Hovland; Robert B Boyd; Mark T Butt; Jeffery A Engelhardt; Michael S Moxness; Mark H Ma; Maurice G Emery; Nadia B Ernst; Randall P Reed; Jillynne R Zeller; Don M Gash; Donna M Masterman; Beth M Potter; Mary E Cosenza; Ruth M Lightfoot
Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) in rhesus monkeys.
Toxicologic pathology 2007;35(5):676-92.
2007: John T Slevin; Don M Gash; Charles D Smith; Greg A Gerhardt; Richard J Kryscio; Himachandra Chebrolu; Ashley Walton; Renee Wagner; A Byron Young
Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal.
Journal of neurosurgery 2007;106(4):614-20.
2007: Wayne A Cass; Richard Grondin; Anders H Andersen; Zhiming Zhang; Peter A Hardy; Lindsay K Hussey-Andersen; William S Rayens; Greg A Gerhardt; Don M Gash
Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys.
Neurobiology of aging 2007;28(2):258-71.
2007: Don M Gash; Yan Chen; Greg Gerhardt
Neurotrophic factors and Parkinson's disease.
Handbook of clinical neurology 2007;83():521-33.
2007: John A Stanford; Michael F Salvatore; Barry M Joyce; Hongyu Zhang; Don M Gash; Greg A Gerhardt
Bilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats.
Neurobiology of aging 2007;28(1):156-65.
2006: Michael F Salvatore; Yi Ai; Brent Fischer; Amanda M Zhang; Richard Grondin; Zhiming Zhang; Greg A Gerhardt; Don M Gash
Point source concentration of GDNF may explain failure of phase II clinical trial.
Experimental neurology 2006;202(2):497-505.
2006: Zhiming Zhang; Anders H Andersen; Yi Ai; Aaron Loveland; Peter A Hardy; Greg A Gerhardt; Don M Gash
Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques.
NeuroImage 2006;33(2):636-43.
2006: Ashley Walton; Amy Branham; Don M Gash; Richard Grondin
Automated video analysis of age-related motor deficits in monkeys using EthoVision.
Neurobiology of aging 2006;27(10):1477-83.
2006: John T Slevin; Greg A Gerhardt; Charles D Smith; Don M Gash; A Byron Young
Reply: GDNF poses troubling questions for doctors, drug maker.
Annals of neurology 2006;59(6):989-90.
2006: Richard D Penn; Arif Dalvi; John T Slevin; Byron Young; Don M Gash; Greg Gerhardt; Michael Hutchinson
GDNF in treatment of Parkinson's disease: response to editorial.
Lancet neurology 2006;5(3):202-3.
2006: John T Slevin; Don M Gash; Charles D Smith; Greg A Gerhardt; Richard J Kryscio; Himachandra Chebrolu; Ashley Walton; Renee Wagner; A Byron Young
Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal.
Neurosurgical focus 2006;20(5):E1.
2005: Yan Chen; Yi Ai; John R Slevin; Bruce E Maley; Don M Gash
Progenitor proliferation in the adult hippocampus and substantia nigra induced by glial cell line-derived neurotrophic factor.
Experimental neurology 2005;196(1):87-95.
2005: Don M Gash; Zhiming Zhang; Yi Ai; Richard Grondin; Robert Coffey; Greg A Gerhardt
Trophic factor distribution predicts functional recovery in parkinsonian monkeys.
Annals of neurology 2005;58(2):224-33.
2005: Charles D Smith; Ashley Walton; A D Loveland; Gloria Umberger; Richard J Kryscio; Don M Gash
Memories that last in old age: motor skill learning and memory preservation.
Neurobiology of aging 2005;26(6):883-90.
2005: John T Slevin; Greg A Gerhardt; Charles D Smith; Don M Gash; Richard J Kryscio; Byron Young
Research on Parkinson disease.
Journal of neurosurgery 2005;102(2):401.
2005: John T Slevin; Greg A Gerhardt; Charles D Smith; Don M Gash; Richard J Kryscio; Byron Young
Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor.
Journal of neurosurgery 2005;102(2):216-22.
2005: Peter A Hardy; Don M Gash; Robert Yokel; Anders Andersen; Yi Ai; Zhiming Zhang
Correlation of R2 with total iron concentration in the brains of rhesus monkeys.
Journal of magnetic resonance imaging : JMRI 2005;21(2):118-27.
2005: J Zhang; D M Stanton; Xuan V Nguyen; Mei Liu; Zhiming Zhang; Don M Gash; Guoying Bing
Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits.
Neuroscience 2005;135(3):829-38.
2004: Navin Maswood; Jennifer Young; Edward Tilmont; Zhiming Zhang; Don M Gash; Greg A Gerhardt; Richard Grondin; George S Roth; Julie A Mattison; Mark A Lane; Richard E Carson; Robert M Cohen; Peter R Mouton; Christopher Quigley; Mark P Mattson; Donald Ingram
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):18171-6.
2004: Michael F Salvatore; Jin-Lu Zhang; Delia M Large; Patsy E Wilson; Clelland R Gash; Theresa Currier Thomas; John W Haycock; Guoying Bing; John A Stanford; Don M Gash; Greg A Gerhardt
Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra.
Journal of neurochemistry 2004;90(1):245-54.
2003: Hui-Ling Chen; Pamela J Lein; Jia-Yi Wang; Don M Gash; Barry Hoffer; Yung-Hsiao Chiang
Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals.
Brain research 2003;994(1):81-90.
2003: Yi Ai; William R Markesbery; Zhiming Zhang; Richard Grondin; Dennis Elseberry; Greg A Gerhardt; Don M Gash
Intraputamenal infusion of GDNF in aged rhesus monkeys: distribution and dopaminergic effects.
The Journal of comparative neurology 2003;461(2):250-61.
2003: Richard Grondin; Wayne A Cass; Zhiming Zhang; John A Stanford; Don M Gash; Greg A Gerhardt
Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(5):1974-80.
2003: Richard Grondin; Zhiming Zhang; Yi Ai; Don M Gash; Greg A Gerhardt
Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2003;61():101-23.
2002: Anders H Andersen; Zhiming Zhang; Malcolm J Avison; Don M Gash
Automated segmentation of multispectral brain MR images.
Journal of neuroscience methods 2002;122(1):13-23.
2002: Richard Grondin; Zhiming Zhang; Ai Yi; Wayne A Cass; Navin Maswood; Anders H Andersen; Dennis D Elsberry; Michael C Klein; Greg A Gerhardt; Don M Gash
Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys.
Brain : a journal of neurology 2002;125(Pt 10):2191-201.
2002: Navin Maswood; Richard Grondin; Zhiming Zhang; John A Stanford; Stewart P Surgener; Don M Gash; Greg A Gerhardt
Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in aged Rhesus monkeys.
Neurobiology of aging 2002;23(5):881-9.
2002: Anders H Andersen; Zhiming Zhang; Tracy Barber; William S Rayens; Jinlu Zhang; Richard Grondin; Peter A Hardy; Greg A Gerhardt; Don M Gash
Functional MRI studies in awake rhesus monkeys: methodological and analytical strategies.
Journal of neuroscience methods 2002;118(2):141-52.
2002: Greg A Gerhardt; Wayne A Cass; Ai Yi; Zhiming Zhang; Don M Gash
Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys.
Journal of neurochemistry 2002;80(1):168-77.
2001: Zhiming Zhang; A Andersen; Richard Grondin; T Barber; R Avison; Greg A Gerhardt; Don M Gash
Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys.
NeuroImage 2001;14(5):1159-67.
2001: C M Fox; Don M Gash; M K Smoot; Wayne A Cass
Neuroprotective effects of GDNF against 6-OHDA in young and aged rats.
Brain research 2001;896(1-2):56-63.
2001: Richard Grondin; Zhiming Zhang; Dennis D Elsberry; Greg A Gerhardt; Don M Gash
Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism.
Methods in molecular medicine 2001;62():257-67.
2000: Zhiming Zhang; A Andersen; C Smith; Richard Grondin; Greg A Gerhardt; Don M Gash
Motor slowing and parkinsonian signs in aging rhesus monkeys mirror human aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2000;55(10):B473-80.
2000: Richard Grondin; Zhiming Zhang; Greg A Gerhardt; Don M Gash
Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys.
Annals of neurology 2000;48(2):250-3.
2000: Zhiming Zhang; Anders H Andersen; Malcolm J Avison; Greg A Gerhardt; Don M Gash
Functional MRI of apomorphine activation of the basal ganglia in awake rhesus monkeys.
Brain research 2000;852(2):290-6.
1999: Charles D Smith; Gloria Umberger; E L Manning; John T Slevin; David R Wekstein; Frederick A Schmitt; William R Markesbery; Zhiming Zhang; Greg A Gerhardt; Richard J Kryscio; Don M Gash
Critical decline in fine motor hand movements in human aging.
Neurology 1999;53(7):1458-61.
1999: WENZHEN DUAN; Zhiming Zhang; Don M Gash; Mark P Mattson
Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease.
Annals of neurology 1999;46(4):587-97.
1999: Don M Gash; Zhiming Zhang; Gloria Umberger; K Mahood; M Smith; C Smith; Greg A Gerhardt
An automated movement assessment panel for upper limb motor functions in rhesus monkeys and humans.
Journal of neuroscience methods 1999;89(2):111-7.
1999: Qinghua Chen; Anders H Andersen; Zhiming Zhang; A Ovadia; Wayne A Cass; Don M Gash; Malcolm J Avison
Functional MRI of basal ganglia responsiveness to levodopa in parkinsonian rhesus monkeys.
Experimental neurology 1999;158(1):63-75.
1999: Anders H Andersen; Don M Gash; Malcolm J Avison
Principal component analysis of the dynamic response measured by fMRI: a generalized linear systems framework.
Magnetic resonance imaging 1999;17(6):795-815.
1999: Anders H Andersen; Zhiming Zhang; M Zhang; Don M Gash; Malcolm J Avison
Age-associated changes in rhesus CNS composition identified by MRI.
Brain research 1999;829(1-2):90-8.
1999: Greg A Gerhardt; Wayne A Cass; Peter Huettl; S Brock; Z Zhang; Don M Gash
GDNF improves dopamine function in the substantia nigra but not the putamen of unilateral MPTP-lesioned rhesus monkeys.
Brain research 1999;817(1-2):163-71.
1999: Zhiming Zhang; M Zhang; Yi Ai; C Avison; Don M Gash
MPTP-Induced pallidal lesions in rhesus monkeys.
Experimental neurology 1999;155(1):140-9.
1998: Richard Grondin; Don M Gash
Glial cell line-derived neurotrophic factor (GDNF): a drug candidate for the treatment of Parkinson's disease.
Journal of neurology 1998;245(11 Suppl 3):P35-42.
1998: Don M Gash; Zhiming Zhang; Greg A Gerhardt
Neuroprotective and neurorestorative properties of GDNF.
Annals of neurology 1998;44(3 Suppl 1):S121-5.
1998: David M Yurek; S B Hipkens; M A Hebert; Don M Gash; Greg A Gerhardt
Age-related decline in striatal dopamine release and motoric function in brown Norway/Fischer 344 hybrid rats.
Brain research 1998;791(1-2):246-56.
1998: Paul A Lapchak; Dalia M Araujo; Dana Hilt; S Jiao; F Collin; Y Miyoshi; Ai Yi; Zhiming Zhang; Don M Gash
Topographical distribution of [125I]-glial cell line-derived neurotrophic factor in unlesioned and MPTP-lesioned rhesus monkey brain following a bolus intraventricular injection.
Brain research 1998;789(1):9-22.
1998: Don M Gash; Greg A Gerhardt; Barry Hoffer
Effects of glial cell line-derived neurotrophic factor on the nigrostriatal dopamine system in rodents and nonhuman primates.
Advances in pharmacology (San Diego, Calif.) 1998;42():911-5.
1997: C M Kearns; Wayne A Cass; K Smoot; Richard J Kryscio; Don M Gash
GDNF protection against 6-OHDA: time dependence and requirement for protein synthesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):7111-8.
1997: Zhiming Zhang; Y Miyoshi; Paul A Lapchak; F Collins; Dana Hilt; Carl LeBel; Richard J Kryscio; Don M Gash
Dose response to intraventricular glial cell line-derived neurotrophic factor administration in parkinsonian monkeys.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1396-401.
1997: Y Miyoshi; Zhiming Zhang; A Ovadia; Paul A Lapchak; F Collins; Dana Hilt; Carl LeBel; Richard J Kryscio; Don M Gash
Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys.
Annals of neurology 1997;42(2):208-14.
1997: Paul A Lapchak; Don M Gash; F Collins; Dana Hilt; PJ Miller; Dalia M Araujo
Pharmacological activities of glial cell line-derived neurotrophic factor (GDNF): preclinical development and application to the treatment of Parkinson's disease.
Experimental neurology 1997;145(2 Pt 1):309-21.
1997: Paul A Lapchak; Don M Gash; S Jiao; PJ Miller; Dana Hilt
Glial cell line-derived neurotrophic factor: a novel therapeutic approach to treat motor dysfunction in Parkinson's disease.
Experimental neurology 1997;144(1):29-34.
1996: Don M Gash; Zhiming Zhang; A Ovadia; Wayne A Cass; A Yi; L Simmerman; D Russell; D Martin; Paul A Lapchak; F Collins; Barry Hoffer; Greg A Gerhardt
Functional recovery in parkinsonian monkeys treated with GDNF.
Nature 1996;380(6571):252-5.
1996: Greg A Gerhardt; Wayne A Cass; J Hudson; M Henson; Zhiming Zhang; A Ovadia; Barry Hoffer; Don M Gash
In vivo electrochemical studies of dopamine overflow and clearance in the striatum of normal and MPTP-treated rhesus monkeys.
Journal of neurochemistry 1996;66(2):579-88.
1996: Q Chen; Anders H Andersen; Zhiming Zhang; A Ovadia; Don M Gash; Malcolm J Avison
Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI.
Magnetic resonance imaging 1996;14(5):469-76.
1995: Don M Gash; Zhiming Zhang; Wayne A Cass; A Ovadia; L Simmerman; D Martin; D Russell; F Collins; Barry Hoffer; Greg A Gerhardt
Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys.
The Journal of comparative neurology 1995;363(3):345-58.
1995: Greg A Gerhardt; Wayne A Cass; M Henson; Zhiming Zhang; A Ovadia; Barry Hoffer; Don M Gash
Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkey.
Neurobiology of aging 1995;16(6):939-46.
1995: A Ovadia; Zhiming Zhang; Don M Gash
Increased susceptibility to MPTP toxicity in middle-aged rhesus monkeys.
Neurobiology of aging 1995;16(6):931-7.
1995: C M Kearns; Don M Gash
GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo.
Brain research 1995;672(1-2):104-11.
1995: Wayne A Cass; Greg A Gerhardt; Zhiming Zhang; A Ovadia; Don M Gash
Increased dopamine clearance in the non-lesioned striatum of rhesus monkeys with unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) striatal lesions.
Neuroscience letters 1995;185(1):52-5.