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Thomas Gasiewicz

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Fanny L Casado; Kameshwar P Singh; Thomas A Gasiewicz
Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration.
Kameshwar P Singh; Russell W Garrett; Fanny L Casado; Thomas A Gasiewicz
Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions.
Sarah E Latchney; Daniel T Lioy; Ellen C Henry; Thomas A Gasiewicz; Frederick G Strathmann; Margot Mayer-Pröschel; Lisa A Opanashuk
Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

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2011: Fanny L Casado; Kameshwar P Singh; Thomas A Gasiewicz
Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration.
Molecular pharmacology 2011;80(4):673-82.
2011: Kameshwar P Singh; Russell W Garrett; Fanny L Casado; Thomas A Gasiewicz
Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions.
Stem cells and development 2011;20(5):769-84.
2011: Sarah E Latchney; Daniel T Lioy; Ellen C Henry; Thomas A Gasiewicz; Frederick G Strathmann; Margot Mayer-Pröschel; Lisa A Opanashuk
Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Stem cells and development 2011;20(2):313-26.
2010: Michael D Laiosa; Jeffrey H Mills; Zhi-Wei Lai; Kameshwar P Singh; Frank A Middleton; Thomas A Gasiewicz; Allen Silverstone
Identification of stage-specific gene modulation during early thymocyte development by whole-genome profiling analysis after aryl hydrocarbon receptor activation.
Molecular pharmacology 2010;77(5):773-83.
2010: Fanny L Casado; Kameshwar P Singh; Thomas A Gasiewicz
The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases.
Blood cells, molecules & diseases 2010;44(4):199-206.
2010: Thomas A Gasiewicz; Kameshwar P Singh; Fanny L Casado
The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzene-induced hematopoietic toxicity.
Chemico-biological interactions 2010;184(1-2):246-51.
2010: Ellen C Henry; Stephen L Welle; Thomas A Gasiewicz
TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts.
Toxicological sciences : an official journal of the Society of Toxicology 2010;114(1):90-100.
2009: Kameshwar P Singh; Fanny L Casado; Lisa A Opanashuk; Thomas A Gasiewicz
The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations.
Biochemical pharmacology 2009;77(4):577-87.
2009: Zhengyu Yin; Ellen C Henry; Thomas A Gasiewicz
(-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor.
Biochemistry 2009;48(2):336-45.
2009: Kameshwar P Singh; Amber Wyman; Fanny L Casado; Russell W Garrett; Thomas A Gasiewicz
Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells.
Carcinogenesis 2009;30(1):11-9.
2008: Chad M Vezina; Sarah Hicks Allgeier; Robert W Moore; Tien-Min Lin; Jeffrey Bemis; Heather A Hardin; Thomas A Gasiewicz; Richard E Peterson
Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(2):488-96.
2008: Carolyn J Baglole; Sanjay B Maggirwar; Thomas A Gasiewicz; Thomas H Thatcher; Richard P Phipps; Patricia J Sime
The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.
The Journal of biological chemistry 2008;283(43):28944-57.
2008: Loretta Collins; Mary A Williamson; Bryan D Thompson; Daniel P Dever; Thomas A Gasiewicz; Lisa A Opanashuk
2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum.
Toxicological sciences : an official journal of the Society of Toxicology 2008;103(1):125-36.
2008: Ellen C Henry; Thomas A Gasiewicz
Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor.
Archives of biochemistry and biophysics 2008;472(2):77-88.
2008: Thomas A Gasiewicz; Ellen C Henry; Loretta Collins
Expression and activity of aryl hydrocarbon receptors in development and cancer.
Critical reviews in eukaryotic gene expression 2008;18(4):279-321.
2007: Elizabeth P Ryan; Jonathan D Holz; Mary Mulcahey; Tzong-Jen Sheu; Thomas A Gasiewicz; J Edward Puzas
Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(10):1571-80.
2007: Thomas H Thatcher; Sanjay B Maggirwar; Carolyn J Baglole; Heather F Lakatos; Thomas A Gasiewicz; Richard P Phipps; Patricia J Sime
Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.
The American journal of pathology 2007;170(3):855-64.
2007: Jeffrey C Bemis; Napoleon F Alejandro; Daniel A Nazarenko; Andrew I Brooks; Raymond B Baggs; Thomas A Gasiewicz
TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(1):240-8.
2006: Russell W Garrett; Thomas A Gasiewicz
The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin alters the circadian rhythms, quiescence, and expression of clock genes in murine hematopoietic stem and progenitor cells.
Molecular pharmacology 2006;69(6):2076-83.
2006: Ellen C Henry; Jeffrey C Bemis; O Henry; Andrew S Kende; Thomas A Gasiewicz
A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo.
Archives of biochemistry and biophysics 2006;450(1):67-77.
2006: Sun-Hee Kim; Ellen C Henry; Dong-Kyu Kim; Yun-Hee Kim; Kum-Joo Shin; Myoung-Sook Han; Taehoon G Lee; Jong-Ku Kang; Thomas A Gasiewicz; Sung Ho Ryu; Pann-Ghill Suh
Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.
Molecular pharmacology 2006;69(6):1871-8.
2005: Jeffrey C Bemis; Daniel A Nazarenko; Thomas A Gasiewicz
Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines.
Toxicological sciences : an official journal of the Society of Toxicology 2005;87(2):529-36.
2005: Christine A Martey; Carolyn J Baglole; Thomas A Gasiewicz; Patricia J Sime; Richard P Phipps
The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts.
American journal of physiology. Lung cellular and molecular physiology 2005;289(3):L391-9.
2005: Christine M Palermo; Claire A Westlake; Thomas A Gasiewicz
Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein.
Biochemistry 2005;44(13):5041-52.
2005: Mary A Williamson; Thomas A Gasiewicz; Lisa A Opanashuk
Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(2):340-8.
2004: Carissa R Filbrandt; Zhenhua Wu; Berislav V Zlokovic; Lisa A Opanashuk; Thomas A Gasiewicz
Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes.
Neurotoxicology 2004;25(4):605-16.
2004: Gary D Minsavage; Sang-ki Park; Thomas A Gasiewicz
The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that is essential for AhR DNA binding activity, is not a phosphoresidue but augments AhR phosphorylation.
The Journal of biological chemistry 2004;279(20):20582-93.
2003: Aby Joiakim; Patricia A Mathieu; Christine M Palermo; Thomas A Gasiewicz; John J Reiners
The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1279-82.
2003: Michael D Laiosa; Amber Wyman; Francis G Murante; Nancy C Fiore; J Erin Staples; Thomas A Gasiewicz; Allen Silverstone
Cell proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4582-91.
2003: Junguo Zhou; Thomas A Gasiewicz
3'-methoxy-4'-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism.
Archives of biochemistry and biophysics 2003;416(1):68-80.
2003: Christine M Palermo; J I Martin Hernando; Stephen D Dertinger; Andrew S Kende; Thomas A Gasiewicz
Identification of potential aryl hydrocarbon receptor antagonists in green tea.
Chemical research in toxicology 2003;16(7):865-72.
2003: Gary D Minsavage; Daria P Vorojeikina; Thomas A Gasiewicz
Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements.
Archives of biochemistry and biophysics 2003;412(1):95-105.
2003: Jun-Guo Zhou; Ellen C Henry; Christine M Palermo; Stephen D Dertinger; Thomas A Gasiewicz
Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements.
Molecular pharmacology 2003;63(4):915-24.
2003: Ellen C Henry; Thomas A Gasiewicz
Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis.
Molecular pharmacology 2003;63(2):392-400.
2002: Michael D Laiosa; Zhi-Wei Lai; T Scott Thurmond; Nancy C Fiore; Charles DeRossi; Bernadette C Holdener; Thomas A Gasiewicz; Allen Silverstone
2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2.
Toxicological sciences : an official journal of the Society of Toxicology 2002;69(1):117-24.
2002: Amber Wyman; Amy L Lavin; Gregory E Wilding; Thomas A Gasiewicz
2,3,7,8-tetrachlorodibenzo-p-dioxin does not directly alter the phenotype of maturing B cells in a murine coculture system.
Toxicology and applied pharmacology 2002;180(3):164-77.
2001: Daniel A Nazarenko; Stephen D Dertinger; Thomas A Gasiewicz
In vivo antagonism of AhR-mediated gene induction by 3'-methoxy-4'-nitroflavone in TCDD-responsive lacZ mice.
Toxicological sciences : an official journal of the Society of Toxicology 2001;61(2):256-64.
2001: Daniel A Nazarenko; Stephen D Dertinger; Thomas A Gasiewicz
Enhanced detection of beta-galactosidase reporter activation is achieved by a reduction of hemoglobin content in tissue lysates.
BioTechniques 2001;30(4):776-7, 780-1.
2001: Stephen D Dertinger; Daniel A Nazarenko; Allen Silverstone; Thomas A Gasiewicz
Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.
Carcinogenesis 2001;22(1):171-7.
2000: T Scott Thurmond; Thomas A Gasiewicz
A single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin produces a time- and dose-dependent alteration in the murine bone marrow B-lymphocyte maturation profile.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(1):88-95.
2000: Zhi-Wei Lai; Nancy C Fiore; Peter J Hahn; Thomas A Gasiewicz; Allen Silverstone
Differential effects of diethylstilbestrol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture.
Toxicology and applied pharmacology 2000;168(1):15-24.
2000: S Park; Ellen C Henry; Thomas A Gasiewicz
Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation.
Archives of biochemistry and biophysics 2000;381(2):302-12.
2000: Stephen D Dertinger; Hoffman B M Lantum; Allen Silverstone; Thomas A Gasiewicz
Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms.
Biochemical pharmacology 2000;60(2):189-96.
2000: T Scott Thurmond; Francis G Murante; J Erin Staples; Allen Silverstone; K S Korach; Thomas A Gasiewicz
Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse.
Endocrinology 2000;141(7):2309-18.
2000: T Scott Thurmond; J Erin Staples; Allen Silverstone; Thomas A Gasiewicz
The aryl hydrocarbon receptor has a role in the in vivo maturation of murine bone marrow B lymphocytes and their response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 2000;165(3):227-36.
2000: Francis G Murante; Thomas A Gasiewicz
Hemopoietic progenitor cells are sensitive targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J mice.
Toxicological sciences : an official journal of the Society of Toxicology 2000;54(2):374-83.
2000: Stephen D Dertinger; Dorothea K Torous; Nikki E Hall; Carol R Tometsko; Thomas A Gasiewicz
Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry.
Mutation research 2000;464(2):195-200.
2000: Thomas A Gasiewicz; T Scott Thurmond; J Erin Staples; Francis G Murante; Allen Silverstone
Use of bone marrow chimeras to identify cell targets in the immune system for the actions of chemicals.
Annals of the New York Academy of Sciences 2000;919():300-3.
1999: J Erin Staples; Thomas A Gasiewicz; Nancy C Fiore; D B Lubahn; K S Korach; Allen Silverstone
Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4168-74.
1999: T Scott Thurmond; Allen Silverstone; Raymond B Baggs; F W Quimby; J Erin Staples; Thomas A Gasiewicz
A chimeric aryl hydrocarbon receptor knockout mouse model indicates that aryl hydrocarbon receptor activation in hematopoietic cells contributes to the hepatic lesions induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 1999;158(1):33-40.
1999: Ellen C Henry; Andrew S Kende; G Rucci; M J Totleben; J J Willey; Stephen D Dertinger; R S Pollenz; Jeffrey P Jones; Thomas A Gasiewicz
Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation.
Molecular pharmacology 1999;55(4):716-25.
1998: Stephen D Dertinger; Allen Silverstone; Thomas A Gasiewicz
Influence of aromatic hydrocarbon receptor-mediated events on the genotoxicity of cigarette smoke condensate.
Carcinogenesis 1998;19(11):2037-42.
1998: J Erin Staples; Nancy C Fiore; D E Frazier; Thomas A Gasiewicz; Allen Silverstone
Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7, 8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 1998;151(1):200-10.
1998: J J Willey; Barry R Stripp; Raymond B Baggs; Thomas A Gasiewicz
Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice.
Toxicology and applied pharmacology 1998;151(1):33-44.
1998: J Erin Staples; Francis G Murante; Nancy C Fiore; Thomas A Gasiewicz; Allen Silverstone
Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3844-54.
1998: Zhi-Wei Lai; Nancy C Fiore; Thomas A Gasiewicz; Allen Silverstone
2,3,7,8-Tetrachlorodibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture.
Toxicology and applied pharmacology 1998;149(2):167-77.
1998: A L Lavin; D J Hahn; Thomas A Gasiewicz
Expression of functional aromatic hydrocarbon receptor and aromatic hydrocarbon nuclear translocator proteins in murine bone marrow stromal cells.
Archives of biochemistry and biophysics 1998;352(1):9-18.
1997: Ellen C Henry; T A Kent; Thomas A Gasiewicz
DNA binding and transcriptional enhancement by purified TCDD.Ah receptor complex.
Archives of biochemistry and biophysics 1997;339(2):305-14.
1997: Thomas A Gasiewicz
Dioxins and the Ah receptor: probes to uncover processes in neuroendocrine development.
Neurotoxicology 1997;18(2):393-413.
1996: Thomas A Gasiewicz; Andrew S Kende; G Rucci; B Whitney; J J Willey
Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones, and related compounds.
Biochemical pharmacology 1996;52(11):1787-803.
1996: Dori R Germolec; Ellen C Henry; R Maronpot; Julie F Foley; N H Adams; Thomas A Gasiewicz; Michael I Luster
Induction of CYP1A1 and ALDH-3 in lymphoid tissues from Fisher 344 rats exposed to 2,3,7,8-tetrachlorodibenzodioxin (TCDD).
Toxicology and applied pharmacology 1996;137(1):57-66.
1995: T E White; G Rucci; Z Liu; Thomas A Gasiewicz
Weanling female Sprague-Dawley rats are not sensitive to the antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Toxicology and applied pharmacology 1995;133(2):313-20.
1995: M J Mahon; Thomas A Gasiewicz
Ah receptor phosphorylation: localization of phosphorylation sites to the C-terminal half of the protein.
Archives of biochemistry and biophysics 1995;318(1):166-74.
1994: Ellen C Henry; G Rucci; Thomas A Gasiewicz
Purification to homogeneity of the heteromeric DNA-binding form of the aryl hydrocarbon receptor from rat liver.
Molecular pharmacology 1994;46(6):1022-7.
1994: D E Frazier; Allen Silverstone; Thomas A Gasiewicz
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced thymic atrophy and lymphocyte stem cell alterations by mechanisms independent of the estrogen receptor.
Biochemical pharmacology 1994;47(11):2039-48.
1994: Allen Silverstone; D E Frazier; Nancy C Fiore; J A Soults; Thomas A Gasiewicz
Dexamethasone, beta-estradiol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets.
Toxicology and applied pharmacology 1994;126(2):248-59.
1994: D E Frazier; Allen Silverstone; J A Soults; Thomas A Gasiewicz
The thymus does not mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin-elicited alterations in bone marrow lymphocyte stem cells.
Toxicology and applied pharmacology 1994;124(2):242-7.
1994: Allen Silverstone; D E Frazier; Thomas A Gasiewicz
Alternate immune system targets for TCDD: lymphocyte stem cells and extrathymic T-cell development.
Experimental and clinical immunogenetics 1994;11(2-3):94-101.
1993: Ellen C Henry; Thomas A Gasiewicz
Transformation of the aryl hydrocarbon receptor to a DNA-binding form is accompanied by release of the 90 kDa heat-shock protein and increased affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin.
The Biochemical journal 1993;294 ( Pt 1)():95-101.
1993: T E White; Thomas A Gasiewicz
The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: a possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Biochemical and biophysical research communications 1993;193(3):956-62.
1992: M J Mahon; Thomas A Gasiewicz
Chelatable metal ions are not required for aryl hydrocarbon receptor transformation to a DNA binding form: phenanthrolines are possible competitive antagonists of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Archives of biochemistry and biophysics 1992;297(1):1-8.
1991: Ellen C Henry; K A Hayden; P A Bauman; Thomas A Gasiewicz
Ribonuclease inhibits Ah receptor transformation in vitro.
The Biochemical journal 1991;279 ( Pt 3)():689-94.
1991: Thomas A Gasiewicz; G Rucci
Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor.
Molecular pharmacology 1991;40(5):607-12.
1991: Ellen C Henry; Thomas A Gasiewicz
Inhibition and reconstitution of Ah receptor transformation in vitro: role and partial characterization of a cytosolic factor(s).
Archives of biochemistry and biophysics 1991;288(1):149-56.
1991: Thomas A Gasiewicz; C J Elferink; Ellen C Henry
Characterization of multiple forms of the Ah receptor: recognition of a dioxin-responsive enhancer involves heteromer formation.
Biochemistry 1991;30(11):2909-16.
1990: C J Elferink; Thomas A Gasiewicz; James P Whitlock
Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric.
The Journal of biological chemistry 1990;265(33):20708-12.
1990: J S Fine; Thomas A Gasiewicz; Nancy C Fiore; Allen Silverstone
Prothymocyte activity is reduced by perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.
The Journal of pharmacology and experimental therapeutics 1990;255(1):128-32.
1990: J S Fine; Allen Silverstone; Thomas A Gasiewicz
Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1169-76.
1989: M F Ackermann; Thomas A Gasiewicz; K R Lamm; Dori R Germolec; Michael I Luster
Selective inhibition of polymorphonuclear neutrophil activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 1989;101(3):470-80.
1989: Ellen C Henry; G Rucci; Thomas A Gasiewicz
Characterization of multiple forms of the Ah receptor: comparison of species and tissues.
Biochemistry 1989;28(15):6430-40.
1989: Mark E Hahn; Joyce A Goldstein; P Linko; Thomas A Gasiewicz
Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor agonist.
Archives of biochemistry and biophysics 1989;270(1):344-55.
1989: J S Fine; Thomas A Gasiewicz; Allen Silverstone
Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Molecular pharmacology 1989;35(1):18-25.
1988: Mark E Hahn; Thomas A Gasiewicz; P Linko; Joyce A Goldstein
The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice.
The Biochemical journal 1988;254(1):245-54.
1988: G Rucci; Thomas A Gasiewicz
In vivo kinetics and DNA-binding properties of the Ah receptor in the golden Syrian hamster.
Archives of biochemistry and biophysics 1988;265(1):197-207.
1988: Ellen C Henry; J E Kester; Thomas A Gasiewicz
Effects of SH-modifying reagents on the rat hepatic Ah receptor: inhibition of ligand binding and transformation, and disruption of the ligand-receptor complex.
Biochimica et biophysica acta 1988;964(3):361-76.
1987: J E Kester; Thomas A Gasiewicz
Influence of proteinase inhibitors and substrates on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-binding capacity of the rat hepatic Ah receptor.
Biochimica et biophysica acta 1987;925(2):109-16.
1987: Ellen C Henry; Thomas A Gasiewicz
Changes in thyroid hormones and thyroxine glucuronidation in hamsters compared with rats following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 1987;89(2):165-74.
1987: Thomas A Gasiewicz; P A Bauman
Heterogeneity of the rat hepatic Ah receptor and evidence for transformation in vitro and in vivo.
The Journal of biological chemistry 1987;262(5):2116-20.
1987: J E Kester; Thomas A Gasiewicz
Characterization of the in vitro stability of the rat hepatic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Archives of biochemistry and biophysics 1987;252(2):606-25.
1986: Thomas A Gasiewicz; G Rucci; Ellen C Henry; R B Baggs
Changes in hamster hepatic cytochrome P-450, ethoxycoumarin O-deethylase, and reduced NAD(P): menadione oxidoreductase following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial dissociation of temporal and dose-response relationships from elicited toxicity.
Biochemical pharmacology 1986;35(16):2737-42.
1986: C J Lu; D Redmond; R B Baggs; A Schecter; Thomas A Gasiewicz
Growth and hepatic composition in the guinea pig after long-term parenteral hyperalimentation.
The American journal of physiology 1986;251(2 Pt 2):R388-97.
1986: C J Huang Lu; R B Baggs; D Redmond; Ellen C Henry; A Schecter; Thomas A Gasiewicz
Toxicity and evidence for metabolic alterations in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated guinea pigs fed by total parenteral nutrition.
Toxicology and applied pharmacology 1986;84(3):439-53.
1986: Ellen C Henry; Thomas A Gasiewicz
Effects of thyroidectomy on the Ah receptor and enzyme inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver.
Chemico-biological interactions 1986;59(1):29-42.
1986: P Linko; H N Yeowell; Thomas A Gasiewicz; Joyce A Goldstein
Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice.
Journal of biochemical toxicology 1986;1(2):95-107.
1986: Joyce A Goldstein; P Linko; Mark E Hahn; Thomas A Gasiewicz; H N Yeowell
Structure-activity relationships of chlorinated benzenes as inducers of hepatic cytochrome P-450 isozymes in the rat.
IARC scientific publications 1986;(77):519-26.
1984: Thomas A Gasiewicz; G Rucci
Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species.
Molecular pharmacology 1984;26(1):90-8.
1984: Thomas A Gasiewicz; G Rucci
Examination and rapid analysis of hepatic cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using gel-permeation high performance liquid chromatography.
Biochimica et biophysica acta 1984;798(1):37-45.
1984: Thomas A Gasiewicz; W C Ness; G Rucci
Ontogeny of the cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver, lung, and thymus.
Biochemical and biophysical research communications 1984;118(1):183-90.
1983: Thomas A Gasiewicz; L E Geiger; G Rucci; R A Neal
Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice.
Drug metabolism and disposition: the biological fate of chemicals 1983;11(5):397-403.
1982: R A Neal; J R Olson; Thomas A Gasiewicz; L E Geiger
The toxicokinetics of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mammalian systems.
Drug metabolism reviews 1982;13(3):355-85.
1980: J R Olson; Thomas A Gasiewicz; R A Neal
Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster.
Toxicology and applied pharmacology 1980;56(1):78-85.