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Philippe Gasque

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Chemicals & Drugs

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Riina Oksjoki; Petri Laine; Satu Helske; Pirjo Vehmaan-Kreula; Mikko I Mäyränpää; Philippe Gasque; Petri T Kovanen; Markku O Pentikäinen
Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques.
Jean Francois Jégou; Philippe Chan; Marie-Thérèse Schouft; Philippe Gasque; Hubert Vaudry; Marc Fontaine
Protective DNA vaccination against myelin oligodendrocyte glycoprotein is overcome by C3d in experimental autoimmune encephalomyelitis.
Masashi Mizuno; Stéphanie Blanchin; Philippe Gasque; Kazuhiro Nishikawa; Seiichi Matsuo
High levels of complement C3a receptor in the glomeruli in lupus nephritis.

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All Publications

2007: Riina Oksjoki; Petri Laine; Satu Helske; Pirjo Vehmaan-Kreula; Mikko I Mäyränpää; Philippe Gasque; Petri T Kovanen; Markku O Pentikäinen
Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques.
Atherosclerosis 2007;195(1):90-9.
2007: Jean Francois Jégou; Philippe Chan; Marie-Thérèse Schouft; Philippe Gasque; Hubert Vaudry; Marc Fontaine
Protective DNA vaccination against myelin oligodendrocyte glycoprotein is overcome by C3d in experimental autoimmune encephalomyelitis.
Molecular immunology 2007;44(15):3691-701.
2007: Masashi Mizuno; Stéphanie Blanchin; Philippe Gasque; Kazuhiro Nishikawa; Seiichi Matsuo
High levels of complement C3a receptor in the glomeruli in lupus nephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2007;49(5):598-606.
2007: Jean Francois Jégou; Philippe Chan; Marie-Thérèse Schouft; Mark R Griffiths; Jim W Neal; Philippe Gasque; Hubert Vaudry; Marc Fontaine
C3d binding to the myelin oligodendrocyte glycoprotein results in an exacerbated experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3323-31.
2007: Sandrine Bès-Houtmann; Régis Roche; Laurence Hoareau; Marie-Paule Gonthier; Franck Festy; Henri Caillens; Philippe Gasque; Christian Lefebvre d'Hellencourt; Maya Cesari
Presence of functional TLR2 and TLR4 on human adipocytes.
Histochemistry and cell biology 2007;127(2):131-7.
2007: M Griffiths; Jim W Neal; Philippe Gasque
Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins.
International review of neurobiology 2007;82():29-55.
2006: Duncan S Cole; Timothy R Hughes; Philippe Gasque; B Paul Morgan
Complement regulator loss on apoptotic neuronal cells causes increased complement activation and promotes both phagocytosis and cell lysis.
Molecular immunology 2006;43(12):1953-64.
2006: Cecile Canova; Jim W Neal; Philippe Gasque
Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis.
Journal of neuroinflammation 2006;3():22.
2005: Kristina Elward; Mark Griffiths; Masashi Mizuno; Claire L Harris; Jim W Neal; B Paul Morgan; Philippe Gasque
CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells.
The Journal of biological chemistry 2005;280(43):36342-54.
2005: Mathieu Hauwel; Emeline Furon; Philippe Gasque
Molecular and cellular insights into the coxsackie-adenovirus receptor: role in cellular interactions in the stem cell niche.
Brain research. Brain research reviews 2005;48(2):265-72.
2005: Mathieu Hauwel; Emeline Furon; Cecile Canova; Mark Griffiths; Jim Neal; Philippe Gasque
Innate (inherent) control of brain infection, brain inflammation and brain repair: the role of microglia, astrocytes, "protective" glial stem cells and stromal ependymal cells.
Brain research. Brain research reviews 2005;48(2):220-33.
2005: Johan van Beek; Marjan van Meurs; Bert A 't Hart; Herbert P M Brok; Jim W Neal; Alexandra Chatagner; Claire L Harris; Nader Omidvar; B Paul Morgan; Jon D Laman; Philippe Gasque
Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2353-65.
2004: Jennifer Brady; Jim Neal; Nagarajan Sadakar; Philippe Gasque
Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors.
Journal of neuropathology and experimental neurology 2004;63(12):1274-83.
2004: Philippe Gasque
Complement: a unique innate immune sensor for danger signals.
Molecular immunology 2004;41(11):1089-98.
2004: Gabor Geza Kovacs; Philippe Gasque; Thomas Ströbel; Elisabeth Lindeck-Pozza; Michaela Strohschneider; James W Ironside; Herbert Budka; Marin Guentchev
Complement activation in human prion disease.
Neurobiology of disease 2004;15(1):21-8.
2003: Karen Francis; B Mary Lewis; Hiroyasu Akatsu; Peter N Monk; Stuart A Cain; Maurice F Scanlon; B Paul Morgan; Jack Ham; Philippe Gasque
Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(15):2266-8.
2003: Kristina Elward; Philippe Gasque
"Eat me" and "don't eat me" signals govern the innate immune response and tissue repair in the CNS: emphasis on the critical role of the complement system.
Molecular immunology 2003;40(2-4):85-94.
2003: Tiphaine Monsinjon; Philippe Gasque; Philippe Chan; Alexander Ischenko; Jennifer J Brady; Marc C Fontaine
Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1003-14.
2003: Karen Francis; Johan van Beek; Cecile Canova; Jim W Neal; Philippe Gasque
Innate immunity and brain inflammation: the key role of complement.
Expert reviews in molecular medicine 2003;5(15):1-19.
2003: Johan van Beek; Kristina Elward; Philippe Gasque
Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection.
Annals of the New York Academy of Sciences 2003;992():56-71.
2002: Eamon P McGreal; Nobunao Ikewaki; Hiroyasu Akatsu; B Paul Morgan; Philippe Gasque
Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5222-32.
2002: Philippe Gasque; Jim W Neal; Sim K Singhrao; Eamon P McGreal; Yann D Dean; Beek Johan Van; B Paul Morgan
Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities.
Molecular neurobiology 2002;25(1):1-17.
2002: Cornelia Speth; Manfred P Dierich; Philippe Gasque
Neuroinvasion by pathogens: a key role of the complement system.
Molecular immunology 2002;38(9):669-79.
2001: Yann D Dean; Eamon P McGreal; Philippe Gasque
Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense.
European journal of immunology 2001;31(5):1370-81.
2001: Ernesto Oviedo-Orta; Philippe Gasque; W Howard Evans
Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):768-74.
2001: Tiphaine Monsinjon; Philippe Gasque; Alexander Ischenko; Marc Fontaine
C3A binds to the seven transmembrane anaphylatoxin receptor expressed by epithelial cells and triggers the production of IL-8.
FEBS letters 2001;487(3):339-46.
2000: Cornelia Speth; Günter Rambach; Cornelia Lass-Flörl; Reinhard Wurzner; Philippe Gasque; Iradj Mohsenipour; Manfred P Dierich
Culture supernatants of patient-derived Aspergillus isolates have toxic and lytic activity towards neurons and glial cells.
FEMS immunology and medical microbiology 2000;29(4):303-13.
2000: Yann D Dean; Eamon P McGreal; Hiroyasu Akatsu; Philippe Gasque
Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin.
The Journal of biological chemistry 2000;275(44):34382-92.
2000: Sim K Singhrao; Jim W Neal; Neil K Rushmere; B Paul Morgan; Philippe Gasque
Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis.
The American journal of pathology 2000;157(3):905-18.
2000: Philippe Gasque; Yann D Dean; Eamon P McGreal; J VanBeek; B Paul Morgan
Complement components of the innate immune system in health and disease in the CNS.
Immunopharmacology 2000;49(1-2):171-86.
2000: A Thomas; Philippe Gasque; David Vaudry; B Gonzalez; Marc Fontaine
Expression of a complete and functional complement system by human neuronal cells in vitro.
International immunology 2000;12(7):1015-23.
2000: Johan van Beek; Myriam Bernaudin; Edwige Petit; Philippe Gasque; André Nouvelot; Eric T MacKenzie; Marc Fontaine
Expression of receptors for complement anaphylatoxins C3a and C5a following permanent focal cerebral ischemia in the mouse.
Experimental neurology 2000;161(1):373-82.
1999: Sim K Singhrao; Jim W Neal; Neil K Rushmere; B Paul Morgan; Philippe Gasque
Differential expression of individual complement regulators in the brain and choroid plexus.
Laboratory investigation; a journal of technical methods and pathology 1999;79(10):1247-59.
1999: Sim K Singhrao; Jim W Neal; B Paul Morgan; Philippe Gasque
Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease.
Experimental neurology 1999;159(2):362-76.
1998: Alexander Ischenko; S Sayah; C Patte; S Andreev; Philippe Gasque; Marie-Thérèse Schouft; Hubert Vaudry; Marc Fontaine
Expression of a functional anaphylatoxin C3a receptor by astrocytes.
Journal of neurochemistry 1998;71(6):2487-96.
1998: Philippe Gasque; Sim K Singhrao; Jim W Neal; P Wang; S Sayah; Marc Fontaine; B Paul Morgan
The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3543-54.
1998: Philippe Gasque; J Jones; Sim K Singhrao; B Morgan
Identification of an astrocyte cell population from human brain that expresses perforin, a cytotoxic protein implicated in immune defense.
The Journal of experimental medicine 1998;187(4):451-60.
1997: B Paul Morgan; Philippe Gasque; Sim K Singhrao; S J Piddlesden
The role of complement in disorders of the nervous system.
Immunopharmacology 1997;38(1-2):43-50.
1997: S Sayah; C Patte; Philippe Gasque; Philippe Chan; Alexander Ischenko; Hubert Vaudry; Marc Fontaine
Characterization of rat C5a anaphylatoxin receptor (C5aR): cloning of rat C5aR cDNA and study of C5aR expression by rat astrocytes.
Brain research. Molecular brain research 1997;48(2):215-22.
1997: J Legoedec; Philippe Gasque; J F Jeanne; michel scotté; Marc Fontaine
Complement classical pathway expression by human skeletal myoblasts in vitro.
Molecular immunology 1997;34(10):735-41.
1997: B Paul Morgan; Philippe Gasque; Sim K Singhrao; S J Piddlesden
Role of complement in inflammation and injury in the nervous system.
Experimental and clinical immunogenetics 1997;14(1):19-23.
1997: B Paul Morgan; Philippe Gasque
Extrahepatic complement biosynthesis: where, when and why?
Clinical and experimental immunology 1997;107(1):1-7.
1997: Philippe Gasque; Sim K Singhrao; Jim W Neal; O Götze; B Paul Morgan
Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system.
The American journal of pathology 1997;150(1):31-41.
1996: Philippe Gasque; B Paul Morgan
Complement regulatory protein expression by a human oligodendrocyte cell line: cytokine regulation and comparison with astrocytes.
Immunology 1996;89(3):338-47.
1996: B Paul Morgan; Philippe Gasque
Expression of complement in the brain: role in health and disease.
Immunology today 1996;17(10):461-6.
1996: Philippe Gasque; A Thomas; Marc Fontaine; B Paul Morgan
Complement activation on human neuroblastoma cell lines in vitro: route of activation and expression of functional complement regulatory proteins.
Journal of neuroimmunology 1996;66(1-2):29-40.
1996: C A Rogers; Philippe Gasque; S J Piddlesden; N Okada; V M Holers; B Paul Morgan
Expression and function of membrane regulators of complement on rat astrocytes in culture.
Immunology 1996;88(1):153-61.
1996: Sim K Singhrao; Jim W Neal; Philippe Gasque; B Paul Morgan; Geoffrey R Newman
Role of complement in the aetiology of Pick's disease?
Journal of neuropathology and experimental neurology 1996;55(5):578-93.
1996: Philippe Gasque; B Paul Morgan; J Legoedec; P Chan; Marc Fontaine
Human skeletal myoblasts spontaneously activate allogeneic complement but are resistant to killing.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3402-11.
1996: M Lamacz; Marie-Christine Tonon; F Smih-Rouet; C Patte; Philippe Gasque; Marc Fontaine; Hubert Vaudry
The endogenous benzodiazepine receptor ligand ODN increases cytosolic calcium in cultured rat astrocytes.
Brain research. Molecular brain research 1996;37(1-2):290-6.
1996: Philippe Gasque; P Chan; C Mauger; M T Schouft; Sim K Singhrao; M P Dierich; B Paul Morgan; Marc Fontaine
Identification and characterization of complement C3 receptors on human astrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(6):2247-55.
1995: J Legoedec; Philippe Gasque; J F Jeanne; Marc Fontaine
Expression of the complement alternative pathway by human myoblasts in vitro: biosynthesis of C3, factor B, factor H and factor I.
European journal of immunology 1995;25(12):3460-6.
1995: Philippe Gasque; P Chan; Marc Fontaine; Alexander Ischenko; M Lamacz; O Götze; B Paul Morgan
Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4882-9.
1995: Philippe Gasque; Marc Fontaine; B Paul Morgan
Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4726-33.
1993: Philippe Gasque; Alexander Ischenko; J Legoedec; C Mauger; M T Schouft; Marc Fontaine
Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells.
The Journal of biological chemistry 1993;268(33):25068-74.
1992: Philippe Gasque; N Julen; Alexander Ischenko; C Picot; C Mauger; C Chauzy; Jean Ripoche; Marc Fontaine
Expression of complement components of the alternative pathway by glioma cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(4):1381-7.