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Jack Gauldie

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Karin Söderlund Leifler; Anna-Karin Olsson; Jennifer Robertson; Susanne Svensson; Annelie Abrahamsson; Christina Bendrik; Jack Gauldie; Charlotta Dabrosin
Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer.
Guillaume Wettstein; Pierre-Simon Bellaye; Philippe Camus; Bruno Crestani; Carmen Garrido; Jack Gauldie; Martin Gleave; Andreas Gunther; Arlette Hammann; Adonis Hazoume; Martin Kolb; Joëlle Marchal-Somme; Olivier Micheau; Paul Soler; Philippe Bonniaud
Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation.
Shyam S Maharaj; Eva Baroke; Jack Gauldie; Martin R J Kolb
Fibrocytes in chronic lung disease--facts and controversies.

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2013: Karin Söderlund Leifler; Anna-Karin Olsson; Jennifer Robertson; Susanne Svensson; Annelie Abrahamsson; Christina Bendrik; Jack Gauldie; Charlotta Dabrosin
Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):4420-30.
2013: Guillaume Wettstein; Pierre-Simon Bellaye; Philippe Camus; Bruno Crestani; Carmen Garrido; Jack Gauldie; Martin Gleave; Andreas Gunther; Arlette Hammann; Adonis Hazoume; Martin Kolb; Joëlle Marchal-Somme; Olivier Micheau; Paul Soler; Philippe Bonniaud
Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(4):1549-60.
2012: Shyam S Maharaj; Eva Baroke; Jack Gauldie; Martin R J Kolb
Fibrocytes in chronic lung disease--facts and controversies.
Pulmonary pharmacology & therapeutics 2012;25(4):263-7.
2012: Bing Xu; Wei Xu; Wenming Zhang; Song Guo Zheng; Sue Buckley; Hui Chen; Jack Gauldie; Martin Kolb; David Warburton; Wei Shi
Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice.
American journal of physiology. Lung cellular and molecular physiology 2012;303(2):L89-96.
2012: Alison C Mackinnon; Ulf J Nilsson; A John Simpson; Tamara Delaine; Sarah L Farnworth; Stuart J Forbes; Jack Gauldie; Michael A Gibbons; Nik Hirani; Hakon Leffler; Tariq Sethi
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3.
American journal of respiratory and critical care medicine 2012;185(5):537-46.
2011: Daniela Damjanovic; Maziar Divangahi; Jack Gauldie; Cory M Hogaboam; Kapilan Kugathasan; Cherrie-Lee Small; Earl G Brown; Anna Zganiacz; Zhou Xing
Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infection.
The American journal of pathology 2011;179(6):2963-76.
2011: Kathrin Steinwede; Ole Tempelhof; Bianca Ueberberg; Tobias Welte; James C Paton; Kjetil Ask; Jennifer Bohling; Kristine Bolte; John W Christman; Jack Gauldie; Martin Kolb; Florian Länger; Shyam Maharaj; Regina Maus; Ulrich A Maus
Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5346-56.
2011: Cory M Yamashita; Scott K Young; Guoying Yu; Rachel L Zemans; Natalie Briones; Megan N Campbell; Lior Dolgonos; Jack Gauldie; Naftali Kaminski; Christopher A G McCulloch; Derek Radisky; David W H Riches; Jennifer Robertson; Tomoko Suzuki; Gregory P Downey
Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis.
The American journal of pathology 2011;179(4):1733-45.
2011: Laszlo Farkas; Jack Gauldie; Daniela Farkas; Wei Shi; Martin Stampfli; Norbert F Voelkel; David Warburton; Martin Kolb
Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice.
American journal of physiology. Lung cellular and molecular physiology 2011;301(4):L391-401.
2011: Martin R J Kolb; Jack Gauldie
Idiopathic pulmonary fibrosis: the matrix is the message.
American journal of respiratory and critical care medicine 2011;184(6):627-9.
2011: Ye Cui; Laszlo Farkas; Martin Kolb; Shyam Maharaj; Jianzhao Niu; Jennifer Robertson; Lisa Waldhauser; Jifeng Wang; Jack Gauldie
Oxidative stress contributes to the induction and persistence of TGF-β1 induced pulmonary fibrosis.
The international journal of biochemistry & cell biology 2011;43(8):1122-33.
2011: Hideya Kitamura; Jianlong Lou; Jennifer Markovics; James D Marks; Shunsuke Minagawa; Tyren Barker; Jody Lynn Baron; Stephanie Cambier; Jack Gauldie; Amanda Leigh Goodsell; Arthur Hill; David Jablons; Jean-Francois Pittet; Jean Publicover; Louis F Reichardt; Sangeeta Somanath; Paul Wolters; Stephen L Nishimura
Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.
The Journal of clinical investigation 2011;121(7):2863-75.
2011: Laszlo Farkas; Jack Gauldie; Norbert F Voelkel; Martin Kolb
Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors.
American journal of respiratory cell and molecular biology 2011;45(1):1-15.
2011: Laszlo Farkas; Jack Gauldie; Wei Shi; David Warburton; Daniela Farkas; Martin Kolb
Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs.
American journal of respiratory cell and molecular biology 2011;44(6):870-8.
2011: Amit Segev; Nafiseh Nili; Beiping Qiang; Azriel B Osherov; Frank J Giordano; Ronen Jaffe; Jack Gauldie; John D Sparkes; Ashley R Fraser; Michelle Ladouceur-Wodzak; Jagdish Butany; Bradley H Strauss
Inhibition of intimal hyperplasia after stenting by over-expression of p15: a member of the INK4 family of cyclin-dependent kinase inhibitors.
Journal of molecular and cellular cardiology 2011;50(3):417-25.
2011: William E Lawson; Timothy S Blackwell; Jack Gauldie
Let It Be: microRNAs impact interstitial lung disease.
American journal of respiratory and critical care medicine 2011;183(1):1-2.
2010: Alice Tarantal; H Chen; T T Shi; C-H Lu; A B Fang; Sue Buckley; M Kolb; Jack Gauldie; David Warburton; Wei Shi
Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(4):907-14.
2010: Kjetil Ask; Oliver Eickelberg; Jack Gauldie; Naftali Kaminski; Martin Kolb
Have advanced research technologies made real impact on respiratory medicine?
Respirology (Carlton, Vic.) 2010;15(6):876-80.
2010: Dalit Barkan; Lara H El Touny; Aleksandra M Michalowski; Jane Ann Smith; Isabel Chu; Anne Sally Davis; Joshua D Webster; Shelley Hoover; R Mark Simpson; Jack Gauldie; Jeffrey E Green
Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment.
Cancer research 2010;70(14):5706-16.
2010: Margaret M Kelly; Terence M O'Connor; Richard Leigh; Joceline Otis; Carol Gwozd; Gail M Gauvreau; Jack Gauldie; Paul M O'Byrne
Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma.
The Journal of allergy and clinical immunology 2010;125(2):349-356.e13.
2010: Thomas Rodt; Christian von Falck; Sabine Dettmer; Roman Halter; Regina Maus; Kjetil Ask; Martin Kolb; Jack Gauldie; Florian Länger; Ludwig Hoy; Tobias Welte; Michael Galanski; Ulrich A Maus; Jürgen Borlak
Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1.
Respiratory research 2010;11():181.
2010: Christina M Carlson; Elizabeth Turpin; Lindsey A Moser; Kevin B O'Brien; Troy D Cline; Jeremy C Jones; Terrence M Tumpey; Jacqueline M Katz; Laura A Kelley; Jack Gauldie; Stacey Schultz-Cherry
Transforming growth factor-β: activation by neuraminidase and role in highly pathogenic H5N1 influenza pathogenesis.
PLoS pathogens 2010;6(10):e1001136.
2010: Claudia Raja Gabaglia; Alexandra DeLaney; Jennifer Gee; Ramesh Halder; Frank L Graham; Jack Gauldie; Eli E Sercarz; Todd A Braciak
Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice.
Journal of translational medicine 2010;8():98.
2010: Jennifer V Robertson; Elizabeth Golesic; Jack Gauldie; Judith A West-Mays
Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats.
Investigative ophthalmology & visual science 2010;51(1):308-18.
2009: Shunsuke Takenaka; Sarah McCormick; Ekaterina Safroneeva; Zhou Xing; Jack Gauldie
Influence of the tissue microenvironment on Toll-like receptor expression by CD11c+ antigen-presenting cells isolated from mucosal tissues.
Clinical and vaccine immunology : CVI 2009;16(11):1615-23.
2009: Jingyu Mu; Mangalakumari Jeyanathan; Cherrie-Lee Small; Xizhong Zhang; Elizabeth Roediger; Xueya Feng; Duncan Chong; Jack Gauldie; Zhou Xing
Immunization with a bivalent adenovirus-vectored tuberculosis vaccine provides markedly improved protection over its monovalent counterpart against pulmonary tuberculosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):1093-100.
2009: Laszlo Farkas; Daniela Farkas; Kjetil Ask; Antje Möller; Jack Gauldie; Peter Margetts; Mark Inman; Martin Kolb
VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats.
The Journal of clinical investigation 2009;119(5):1298-311.
2009: Antje Moeller; Sarah E Gilpin; Kjetil Ask; Gerard Cox; Deborah Cook; Jack Gauldie; Peter J Margetts; Laszlo Farkas; Julian Dobranowski; Colm Boylan; Paul M O'Byrne; Robert M Strieter; Martin Kolb
Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis.
American journal of respiratory and critical care medicine 2009;179(7):588-94.
2008: Raymond H See; Martin Petric; David J Lawrence; Catherine P Y Mok; Thomas Rowe; Lois A Zitzow; Karuna P Karunakaran; Thomas G Voss; Robert brunham; Jack Gauldie; B Brett Finlay; Rachel L Roper
Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines.
The Journal of general virology 2008;89(Pt 9):2136-46.
2008: Sarah McCormick; Michael Santosuosso; Cherrie-Lee Small; Christopher R Shaler; Xizhong Zhang; Mangalakumari Jeyanathan; Jingyu Mu; Shunsuke Takenaka; Patricia Ngai; Jack Gauldie; Yonghong Wan; Zhou Xing
Mucosally delivered dendritic cells activate T cells independently of IL-12 and endogenous APCs.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2356-67.
2008: Christina Bendrik; Jennifer Robertson; Jack Gauldie; Charlotta Dabrosin
Gene transfer of matrix metalloproteinase-9 induces tumor regression of breast cancer in vivo.
Cancer research 2008;68(9):3405-12.
2008: Peter A Kavsak; Agnes Lee; Hal Hirte; Ed Young; Jack Gauldie
Cytokine elevations in acute coronary syndrome and ovarian cancer: a mechanism for the up-regulation of the acute phase proteins in these different disease etiologies.
Clinical biochemistry 2008;41(7-8):607-10.
2008: Ramzi Fattouh; N Gabriela Midence; Katherine Arias; Jill R Johnson; Tina D Walker; Susanna Goncharova; Kailene P Souza; Richard C Gregory; Scott Lonning; Jack Gauldie; Manel Jordana
Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling.
American journal of respiratory and critical care medicine 2008;177(6):593-603.
2008: Jack Gauldie; Martin Kolb
Animal models of pulmonary fibrosis: how far from effective reality?
American journal of physiology. Lung cellular and molecular physiology 2008;294(2):L151.
2008: Khalil Karimi; Jeanette Boudreau; Katie Fraser; Hongju Liu; Jordan Delanghe; Jack Gauldie; Zhou Xing; Jonathan Bramson; Yonghong Wan
Enhanced antitumor immunity elicited by dendritic cell vaccines is a result of their ability to engage both CTL and IFN gamma-producing NK cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):411-8.
2008: Kjetil Ask; Renee Labiris; Laszlo Farkas; Antje Moeller; Aaron Froese; Troy Farncombe; Grant McClelland; Mark Inman; Jack Gauldie; Martin R J Kolb
Comparison between conventional and "clinical" assessment of experimental lung fibrosis.
Journal of translational medicine 2008;6():16.
2008: Antje Moeller; Kjetil Ask; David Warburton; Jack Gauldie; Martin Kolb
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
The international journal of biochemistry & cell biology 2008;40(3):362-82.
2008: Kjetil Ask; Philippe Bonniaud; Katja Maass; Oliver Eickelberg; Peter J Margetts; David Warburton; John Groffen; Jack Gauldie; Martin Kolb
Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3.
The international journal of biochemistry & cell biology 2008;40(3):484-95.
2007: Jack Gauldie
Inflammation and the aging process: devil or angel.
Nutrition reviews 2007;65(12 Pt 2):S167-9.
2007: A R Froese; Kjetil Ask; Renée Labiris; T Farncombe; David Warburton; Mark D Inman; Jack Gauldie; Martin Kolb
Three-dimensional computed tomography imaging in an animal model of emphysema.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(6):1082-9.
2007: Nathalie Decologne; Martin Kolb; Peter J Margetts; Franck Menetrier; Yves Artur; Carmen Garrido; Jack Gauldie; Philippe Camus; Philippe Bonniaud
TGF-beta1 induces progressive pleural scarring and subpleural fibrosis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6043-51.
2007: Lea Luketic; Jordan Delanghe; Paul T Sobol; Pingchang Yang; Erin Frotten; Karen Mossman; Jack Gauldie; Jonathan Bramson; Yonghong Wan
Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5024-32.
2007: Maziar Divangahi; Tony Yang; Kapilan Kugathasan; Sarah McCormick; Shunsuke Takenaka; Gordon J Gaschler; Ali A Ashkar; Martin Stampfli; Jack Gauldie; Jonathan Bramson; Toshiyuki Takai; Earl Brown; Wayne M Yokoyama; Naoko Aoki; Zhou Xing
Critical negative regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP12 during intracellular infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):4015-26.
2007: Jack Gauldie; Philippe Bonniaud; Patricia J Sime; Kjetil Ask; Martin Kolb
TGF-beta, Smad3 and the process of progressive fibrosis.
Biochemical Society transactions 2007;35(Pt 4):661-4.
2007: Qing Zhu; Christopher W Thomson; Guofeng Zhang; Martin Stämpfli; Mark R McDermott; Stephen Collins; Jack Gauldie
Eosinophilia is induced in the colon of Th2-sensitized mice upon exposure to locally expressed antigen.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G383-90.
2007: Jason Millward; Maria Caruso; Iain L Campbell; Jack Gauldie; Trevor Owens
IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):8175-82.
2007: Shunsuke Takenaka; Ekaterina Safroneeva; Zhou Xing; Jack Gauldie
Dendritic cells derived from murine colonic mucosa have unique functional and phenotypic characteristics.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7984-93.
2007: Claudia Raja Gabaglia; Yaiza Diaz-De-Durana; Frank L Graham; Jack Gauldie; Eli E Sercarz; Todd A Braciak
Attenuation of the glucocorticoid response during Ad5IL-12 adenovirus vector treatment enhances natural killer cell-mediated killing of MHC class I-negative LNCaP prostate tumors.
Cancer research 2007;67(5):2290-7.
2007: Jennifer V Robertson; Zahra Nathu; Anas Najjar; Dhruva J Dwivedi; Jack Gauldie; Judith A West-Mays
Adenoviral gene transfer of bioactive TGFbeta1 to the rodent eye as a novel model for anterior subcapsular cataract.
Molecular vision 2007;13():457-69.
2007: Bruce A Vallance; Nicola Radojevic; Cory M Hogaboam; Yikang Deng; Jack Gauldie; Stephen Collins
IL-4 gene transfer to the small bowel serosa leads to intestinal inflammation and smooth muscle hyperresponsiveness.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(1):G385-94.
2006: Jack Gauldie; Martin Kolb; Kjetil Ask; Gail Martin; Philippe Bonniaud; David Warburton
Smad3 signaling involved in pulmonary fibrosis and emphysema.
Proceedings of the American Thoracic Society 2006;3(8):696-702.
2006: David Warburton; Jack Gauldie; Saverio Bellusci; Wei Shi
Lung development and susceptibility to chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2006;3(8):668-72.
2006: Martin Kolb; Gail Martin; Maria Medina; Kjetil Ask; Jack Gauldie
Gene therapy for pulmonary diseases.
Chest 2006;130(3):879-84.
2006: Margaret M Kelly; Jamila Chakir; Dilini Vethanayagam; Louis-Philippe Boulet; Michel Laviolette; Jack Gauldie; Paul M O'Byrne
Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge.
Chest 2006;130(3):741-53.
2006: Margaret M Kelly; Richard Leigh; Sarah E Gilpin; Elaine Cheng; Gail E M Martin; Katherine Radford; Gerard Cox; Jack Gauldie
Cell-specific gene expression in patients with usual interstitial pneumonia.
American journal of respiratory and critical care medicine 2006;174(5):557-65.
2006: Alice Banh; Paula A Deschamps; Jack Gauldie; Paul A Overbeek; Jacob G Sivak; Judith A West-Mays
Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3.
Investigative ophthalmology & visual science 2006;47(8):3450-60.
2006: Kjetil Ask; Gail E M Martin; Martin Kolb; Jack Gauldie
Targeting genes for treatment in idiopathic pulmonary fibrosis: challenges and opportunities, promises and pitfalls.
Proceedings of the American Thoracic Society 2006;3(4):389-93.
2006: Haitao Wen; Cory M Hogaboam; Jack Gauldie; Steven Kunkel
Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
The American journal of pathology 2006;168(6):1940-50.
2006: Yasuaki Motomura; Waliul I Khan; Rami T El-Sharkawy; Monica Verma-Gandhu; Elena F Verdu; Jack Gauldie; Stephen Collins
Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1.
Gut 2006;55(5):662-70.
2006: Raymond H See; Alexander N Zakhartchouk; Martin Petric; David J Lawrence; Catherine P Y Mok; Robert Jeffrey Hogan; Thomas Rowe; Lois A Zitzow; Karuna P Karunakaran; Mary M Hitt; Frank L Graham; Ludvik Prevec; James B Mahony; Chetna Sharon; Thierry C Auperin; James M Rini; Aubrey J Tingle; David W Scheifele; Danuta M Skowronski; David M Patrick; Thomas G Voss; Lorne A Babiuk; Jack Gauldie; Rachel L Roper; Robert brunham; B Brett Finlay
Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus.
The Journal of general virology 2006;87(Pt 3):641-50.
2006: Kalathil Suresh; Graeme Fraser; Elizabeth Scheid; Brian Leber; Jack Gauldie; Ronan Foley
Generation of in vitro B-CLL specific HLA class I restricted CTL responses using autologous dendritic cells pulsed with necrotic tumor lysate.
Leukemia & lymphoma 2006;47(2):297-306.
2005: Philippe Bonniaud; Peter J Margetts; Kjetil Ask; Kathy Flanders; Jack Gauldie; Martin Kolb
TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5390-5.
2005: Felix Chua; Jack Gauldie; Geoffrey J Laurent
Pulmonary fibrosis: searching for model answers.
American journal of respiratory cell and molecular biology 2005;33(1):9-13.
2005: Bruce A Vallance; M Imelda Gunawan; Bryan Hewlett; Premysl Bercik; Corinne Van Kampen; Francesca Galeazzi; Patricia J Sime; Jack Gauldie; Stephen Collins
TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(1):G116-28.
2005: Kalathil Suresh; Juan Carlos Rodriguez-Lecompte; Jack Gauldie; Ronan Foley
Recent advances in immunotherapy of B-CLL using ex vivo modified dendritic cells.
Hematology (Amsterdam, Netherlands) 2005;10(3):189-203.
2005: Philippe Bonniaud; Peter J Margetts; Martin Kolb; Jane Ann Schroeder; Ann M Kapoun; Debby Damm; Alison Murphy; Sarvajit Chakravarty; Sundeep Dugar; Linda Higgins; Protter Andrew; Jack Gauldie
Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor.
American journal of respiratory and critical care medicine 2005;171(8):889-98.
2005: Margaret M Kelly; Richard Leigh; Philippe Bonniaud; Russ Ellis; Jennifer Wattie; Mary Jo Smith; Gail Martin; Mohammed Panju; Mark D Inman; Jack Gauldie
Epithelial expression of profibrotic mediators in a model of allergen-induced airway remodeling.
American journal of respiratory cell and molecular biology 2005;32(2):99-107.
2005: Steve Gyorffy; Juan Carlos Rodriguez-Lecompte; J Paul Woods; Ronan Foley; Stephen A Kruth; Patricia C Y Liaw; Jack Gauldie
Bone marrow-derived dendritic cell vaccination of dogs with naturally occurring melanoma by using human gp100 antigen.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2005;19(1):56-63.
2005: Alexander N Zakhartchouk; Sathiyanarayanan Viswanathan; James B Mahony; Jack Gauldie; Lorne A Babiuk
Severe acute respiratory syndrome coronavirus nucleocapsid protein expressed by an adenovirus vector is phosphorylated and immunogenic in mice.
The Journal of general virology 2005;86(Pt 1):211-5.
2005: C Van Kampen; Jack Gauldie; Stephen Collins
Proinflammatory properties of IL-4 in the intestinal microenvironment.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(1):G111-7.
2005: Waliul I Khan; Yasuaki Motomura; Patricia Blennerhassett; Hiroshi Kanbayashi; Ashwin K Varghese; Rami T El-Sharkawy; Jack Gauldie; Stephen Collins
Disruption of CD40-CD40 ligand pathway inhibits the development of intestinal muscle hypercontractility and protective immunity in nematode infection.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(1):G15-22.
2005: Yasuaki Motomura; Hiroshi Kanbayashi; Waliul I Khan; Yikang Deng; Patricia Blennerhassett; Peter J Margetts; Jack Gauldie; K Egashira; Stephen Collins
The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-beta type II receptor gene transfer.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(1):G143-50.
2004: Juan Carlos Rodriguez-Lecompte; Stephen A Kruth; Steve Gyorffy; Yonghong Wan; Jack Gauldie
Cell-based cancer gene therapy: breaking tolerance or inducing autoimmunity?
Animal health research reviews / Conference of Research Workers in Animal Diseases 2004;5(2):227-34.
2004: Claudia Raja Gabaglia; Eli E Sercarz; Yaiza Diaz-De-Durana; Mary Hitt; Frank L Graham; Jack Gauldie; Todd A Braciak
Life-long systemic protection in mice vaccinated with L. major and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes.
Vaccine 2004;23(2):247-57.
2004: Philippe Bonniaud; Gail Martin; Peter J Margetts; Kjetil Ask; Jennifer Robertson; Jack Gauldie; Martin Kolb
Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs.
American journal of respiratory cell and molecular biology 2004;31(5):510-6.
2004: Chang-Xin Shi; Michael Long; Limin Liu; Frank L Graham; Jack Gauldie; Mary Hitt
The human SCGB2A2 (mammaglobin-1) promoter/enhancer in a helper-dependent adenovirus vector directs high levels of transgene expression in mammary carcinoma cells but not in normal nonmammary cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(4):758-67.
2004: Philippe Bonniaud; Martin Kolb; Tom Galt; Jennifer Robertson; Clinton Robbins; Martin Stampfli; Carol Lavery; Peter J Margetts; Anita B Roberts; Jack Gauldie
Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2099-108.
2004: Gunilla Westergren-Thorsson; Patricia J Sime; Manel Jordana; Jack Gauldie; Bengt Särnstrand; Anders Malmström
Lung fibroblast clones from normal and fibrotic subjects differ in hyaluronan and decorin production and rate of proliferation.
The international journal of biochemistry & cell biology 2004;36(8):1573-84.
2004: Julian L Griffin; Daniel Anthony; Sandra J Campbell; Jack Gauldie; Fernando J Pitossi; Peter Styles; Nicola R Sibson
Study of cytokine induced neuropathology by high resolution proton NMR spectroscopy of rat urine.
FEBS letters 2004;568(1-3):49-54.
2004: Jacob Bukczynski; Tao Wen; Kim Ellefsen; Jack Gauldie; Tania H Watts
Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1291-6.
2003: Jack Gauldie; Tom Galt; Philippe Bonniaud; Clinton Robbins; Margaret Kelly; David Warburton
Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia.
The American journal of pathology 2003;163(6):2575-84.
2003: Masaki Fujita; John M Shannon; Osamu Morikawa; Jack Gauldie; Nobuyuki Hara; Robert J Mason
Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta.
American journal of respiratory cell and molecular biology 2003;29(6):669-76.
2003: Charlotta Dabrosin; Peter J Margetts; Jack Gauldie
Estradiol increases extracellular levels of vascular endothelial growth factor in vivo in murine mammary cancer.
International journal of cancer. Journal international du cancer 2003;107(4):535-40.
2003: Delphine Boche; Colm Cunningham; Jack Gauldie; V Hugh Perry
Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(10):1174-82.
2003: Suzane Trudel; John Trachtenberg; Ants Toi; Joan Sweet; Zhi Hua Li; Michael Jewett; John Tshilias; Li Hue Zhuang; Mary Hitt; Yonghong Wan; Jack Gauldie; Frank L Graham; Janet Dancey; A Keith Stewart
A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer.
Cancer gene therapy 2003;10(10):755-63.
2003: Philippe Bonniaud; Peter J Margetts; Martin Kolb; Thomas Haberberger; Margaret Kelly; Jennifer Robertson; Jack Gauldie
Adenoviral gene transfer of connective tissue growth factor in the lung induces transient fibrosis.
American journal of respiratory and critical care medicine 2003;168(7):770-8.
2003: Charlotta Dabrosin; Kay Palmer; Jack Gauldie
Oestradiol enhances tumour regression induced by B7-1/IL-2 adenoviral gene transfer in a murine model of breast cancer.
British journal of cancer 2003;89(2):385-90.
2003: Charlotta Dabrosin; Kay Palmer; William J Muller; Jack Gauldie
Estradiol promotes growth and angiogenesis in polyoma middle T transgenic mouse mammary tumor explants.
Breast cancer research and treatment 2003;78(1):1-6.
2003: Todd A Braciak; Brian Pedersen; Judy Chin; Clay Hsiao; E Sally Ward; Igor Maricic; Alex Jahng; Frank L Graham; Jack Gauldie; Eli E Sercarz; Vipin Kumar
Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the V beta 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):765-74.
2003: Margaret Kelly; Martin Kolb; Philippe Bonniaud; Jack Gauldie
Re-evaluation of fibrogenic cytokines in lung fibrosis.
Current pharmaceutical design 2003;9(1):39-49.
2002: Kathryn L Howe; Jack Gauldie; Derek M McKay
TGF-beta effects on epithelial ion transport and barrier: reduced Cl- secretion blocked by a p38 MAPK inhibitor.
American journal of physiology. Cell physiology 2002;283(6):C1667-74.
2002: Richard Leigh; Russ Ellis; Jennifer Wattie; David S Southam; Meta De Hoogh; Jack Gauldie; Paul M O'Byrne; Mark D Inman
Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation.
American journal of respiratory cell and molecular biology 2002;27(5):526-35.
2002: Nicola R Sibson; Andrew M Blamire; V Hugh Perry; Jack Gauldie; Peter Styles; Daniel Anthony
TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway.
Brain : a journal of neurology 2002;125(Pt 11):2446-59.
2002: Charlotta Dabrosin; Steve Gyorffy; Peter J Margetts; Catherine Ross; Jack Gauldie
Therapeutic effect of angiostatin gene transfer in a murine model of endometriosis.
The American journal of pathology 2002;161(3):909-18.
2002: Martin Kolb; Philippe Bonniaud; Tom Galt; Patricia J Sime; Margaret M Kelly; Peter J Margetts; Jack Gauldie
Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains.
American journal of respiratory cell and molecular biology 2002;27(2):141-50.
2002: Kay Palmer; Niki Sharan; Peter C R Emtage; Jack Gauldie; William J Muller; Yonghong Wan
Intratumoral administration of an adenovirus expressing a kinase dead form of ErbB-2 inhibits tumor growth.
Gene therapy 2002;9(13):898-905.
2002: Peter J Margetts; Martin Kolb; Lisa Yu; Catherine M Hoff; Clifford Holmes; Daniel Anthony; Jack Gauldie
Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum.
The American journal of pathology 2002;160(6):2285-94.
2002: Charles C Reed; Jack Gauldie; Renato V Iozzo
Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin.
Oncogene 2002;21(23):3688-95.
2002: Peter C R Emtage; Zhou Xing; Yonghong Wan; Albert Zlotnik; Frank L Graham; Jack Gauldie
Adenoviral-mediated gene transfer of lymphotactin to the lungs of mice and rats results in infiltration and direct accumulation of CD4+, CD8+, and NK cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(5):573-82.
2002: Jack Gauldie
Pro: Inflammatory mechanisms are a minor component of the pathogenesis of idiopathic pulmonary fibrosis.
American journal of respiratory and critical care medicine 2002;165(9):1205-6.
2002: Peter J Margetts; Steve Gyorffy; Martin Kolb; Lisa Yu; Catherine M Hoff; Clifford Holmes; Jack Gauldie
Antiangiogenic and antifibrotic gene therapy in a chronic infusion model of peritoneal dialysis in rats.
Journal of the American Society of Nephrology : JASN 2002;13(3):721-8.
2002: Jack Gauldie; Martin Kolb; Patricia J Sime
A new direction in the pathogenesis of idiopathic pulmonary fibrosis?
Respiratory research 2002;3():1.
2001: Peter J Margetts; Martin Kolb; Tom Galt; Catherine M Hoff; Ty R Shockley; Jack Gauldie
Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function.
Journal of the American Society of Nephrology : JASN 2001;12(10):2029-39.
2001: Steve Gyorffy; Kay Palmer; Jack Gauldie
Adenoviral vector expressing murine angiostatin inhibits a model of breast cancer metastatic growth in the lungs of mice.
The American journal of pathology 2001;159(3):1137-47.
2001: Martin Kolb; Mark Inman; Peter J Margetts; Tom Galt; Jack Gauldie
Budesonide enhances repeated gene transfer and expression in the lung with adenoviral vectors.
American journal of respiratory and critical care medicine 2001;164(5):866-72.
2001: Waliul I Khan; Patricia Blennerhassett; Yikang Deng; Jack Gauldie; Bruce A Vallance; Stephen Collins
IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(1):G102-10.
2001: Martin Kolb; Peter J Margetts; Daniel Anthony; Fernando J Pitossi; Jack Gauldie
Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis.
The Journal of clinical investigation 2001;107(12):1529-36.
2001: Martin Kolb; Peter J Margetts; Patricia J Sime; Jack Gauldie
Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung.
American journal of physiology. Lung cellular and molecular physiology 2001;280(6):L1327-34.
2001: Steve Gyorffy; Kay Palmer; Thomas J Podor; Mary Hitt; Jack Gauldie
Combined treatment of a murine breast cancer model with type 5 adenovirus vectors expressing murine angiostatin and IL-12: a role for combined anti-angiogenesis and immunotherapy.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6212-7.
2001: B Sakić; Jack Gauldie; Judah A Denburg; Henry Szechtman
Behavioral effects of infection with IL-6 adenovector.
Brain, behavior, and immunity 2001;15(1):25-42.
2001: Martin Kolb; Peter J Margetts; Tom Galt; Patricia J Sime; Zhou Xing; M Schmidt; Jack Gauldie
Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin.
American journal of respiratory and critical care medicine 2001;163(3 Pt 1):770-7.
2001: Y Chen; Peter C R Emtage; Q Zhu; Ronan Foley; William Muller; Mary Hitt; Jack Gauldie; Yonghong Wan
Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12.
Gene therapy 2001;8(4):316-23.
2001: Kay Palmer; Mary Hitt; Peter C R Emtage; Steve Gyorffy; Jack Gauldie
Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity.
Gene therapy 2001;8(4):282-90.
2001: Peter J Margetts; Martin Kolb; L Yu; Catherine M Hoff; Jack Gauldie
A chronic inflammatory infusion model of peritoneal dialysis in rats.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2001;21 Suppl 3():S368-72.
2000: Todd A Braciak; WS Gallichan; Frank L Graham; Carl D Richards; A J Ramsay; Kenneth L Rosenthal; Jack Gauldie
Recombinant adenovirus vectors expressing interleukin-5 and -6 specifically enhance mucosal immunoglobulin A responses in the lung.
Immunology 2000;101(3):388-96.
2000: Eckard H Hamelmann; Katsuyuki Takeda; Angela Haczku; Grzegorz Cieslewicz; Leonard D Shultz; Q Hamid; Zhou Xing; Jack Gauldie; Erwin W Gelfand
Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice.
American journal of respiratory cell and molecular biology 2000;23(3):327-34.
2000: Yonghong Wan; Jonathan Bramson; AA Pilon; Q Zhu; Jack Gauldie
Genetically modified dendritic cells prime autoreactive T cells through a pathway independent of CD40L and interleukin 12: implications for cancer vaccines.
Cancer research 2000;60(12):3247-53.
2000: Mary Hitt; Jack Gauldie
Gene vectors for cytokine expression in vivo.
Current pharmaceutical design 2000;6(6):613-32.
2000: J Wang; Denis Snider; Bryan Hewlett; Nicholas W Lukacs; Jack Gauldie; H Liang; Zhou Xing
Transgenic expression of granulocyte-macrophage colony-stimulating factor induces the differentiation and activation of a novel dendritic cell population in the lung.
Blood 2000;95(7):2337-45.
2000: Giovanni Barbara; Zhou Xing; Cory M Hogaboam; Jack Gauldie; Stephen Collins
Interleukin 10 gene transfer prevents experimental colitis in rats.
Gut 2000;46(3):344-9.
2000: Zhou Xing; Martin R Stämpfli; Jack Gauldie
Transient Transgenic Approaches for Investigating the Role of GM-CSF in Pulmonary Inflammation and Immune Diseases.
Methods in molecular medicine 2000;44():161-78.
1999: Yonghong Wan; Peter C R Emtage; Q Zhu; Ronan Foley; AA Pilon; B Roberts; Jack Gauldie
Enhanced immune response to the melanoma antigen gp100 using recombinant adenovirus-transduced dendritic cells.
Cellular immunology 1999;198(2):131-8.
1999: Kay Palmer; Peter C R Emtage; R M Strieter; Jack Gauldie
Transient gene transfer of non-ELR chemokines to rodent lung induces mononuclear cell accumulation and activation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(12):1381-90.
1999: Christine Kerr; Carrie M Langdon; F Graham; Jack Gauldie; Toshiro Hara; Carl D Richards
Adenovirus vector expressing mouse oncostatin M induces acute-phase proteins and TIMP-1 expression in vivo in mice.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(10):1195-205.
1999: Robert Marr; Mary Hitt; Jack Gauldie; William J Muller; Frank L Graham
A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor alpha expressed from an adenovirus vector induces an antitumor response with reduced toxicity.
Cancer gene therapy 1999;6(5):465-74.
1999: Zhou Xing; Todd A Braciak; D Chong; X Feng; J A Schroeder; Jack Gauldie
Adenoviral-mediated gene transfer of interleukin-6 in rat lung enhances antiviral immunoglobulin A and G responses in distinct tissue compartments.
Biochemical and biophysical research communications 1999;258(2):332-5.
1999: Cory M Hogaboam; Kenneth J Simpson; Stephen W Chensue; ML Steinhauser; Nicholas W Lukacs; Jack Gauldie; Robert M Strieter; Steven Kunkel
Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury.
Gene therapy 1999;6(4):573-84.
1999: Yonghong Wan; Peter C R Emtage; Ronan Foley; R Carter; Jack Gauldie
Murine dendritic cells transduced with an adenoviral vector expressing a defined tumor antigen can overcome anti-adenovirus neutralizing immunity and induce effective tumor regression.
International journal of oncology 1999;14(4):771-6.
1999: Peter C R Emtage; Yonghong Wan; Mary Hitt; Frank L Graham; William J Muller; Albert Zlotnik; Jack Gauldie
Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models.
Human gene therapy 1999;10(5):697-709.
1999: A Keith Stewart; Norman Lassam; IC Quirt; Denis J Bailey; Lorne Rotstein; M Krajden; S Dessureault; Steven Gallinger; D Cappe; Yonghong Wan; CL Addison; RC Moen; Jack Gauldie; FL Graham
Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial.
Gene therapy 1999;6(3):350-63.
1999: Claudia Raja Gabaglia; Brian Pedersen; M Hitt; N Burdin; Eli E Sercarz; Frank L Graham; Jack Gauldie; Todd A Braciak
A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4-expressing vector increases disease susceptibility in B10.D2 mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):753-60.
1999: Zhou Xing; Manel Jordana; Jack Gauldie; Jun Wang
Cytokines and pulmonary inflammatory and immune diseases.
Histology and histopathology 1999;14(1):185-201.
1998: Peter C R Emtage; Yonghong Wan; William Muller; Frank L Graham; Jack Gauldie
Enhanced interleukin-2 gene transfer immunotherapy of breast cancer by coexpression of B7-1 and B7-2.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(11):927-37.
1998: CL Addison; Jonathan Bramson; Mary Hitt; William J Muller; Jack Gauldie; Frank L Graham
Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors.
Gene therapy 1998;5(10):1400-9.
1998: Jun Wang; Kay Palmer; J Lŏtvall; S Milan; XF Lei; Klaus I Matthaei; Jack Gauldie; Mark D Inman; Manel Jordana; Zhou Xing
Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia.
The Journal of clinical investigation 1998;102(6):1132-41.
1998: P J Sime; Robert Marr; D Gauldie; Zhou Xing; Bryan Hewlett; F L Graham; Jack Gauldie
Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts.
The American journal of pathology 1998;153(3):825-32.
1998: XF Lei; Y Ohkawara; Martin R Stämpfli; Jack Gauldie; Kenneth Croitoru; Manel Jordana; Zhou Xing
Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation.
Clinical and experimental immunology 1998;113(2):157-65.
1998: E Parks; Robert M Strieter; Nicholas W Lukacs; Jack Gauldie; M Hitt; F L Graham; Steven Kunkel
Transient gene transfer of IL-12 regulates chemokine expression and disease severity in experimental arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4615-9.
1998: Ronan Foley; Stephen Couban; Irwin Walker; K Greene; C S Chen; Hans A Messner; Jack Gauldie
Monitoring soluble interleukin-2 receptor levels in related and unrelated donor allogenic bone marrow transplantation.
Bone marrow transplantation 1998;21(8):769-73.
1998: Jean-Michel Sallenave; Zhou Xing; A J Simpson; Frank L Graham; Jack Gauldie
Adenovirus-mediated expression of an elastase-specific inhibitor (elafin): a comparison of different promoters.
Gene therapy 1998;5(3):352-60.
1998: A Boehler; D Chamberlain; Zhou Xing; Arthur Slutsky; Manel Jordana; Jack Gauldie; Mingyao Liu; Shaf Keshavjee
Adenovirus-mediated interleukin-10 gene transfer inhibits post-transplant fibrous airway obliteration in an animal model of bronchiolitis obliterans.
Human gene therapy 1998;9(4):541-51.
1998: Peter C R Emtage; Yonghong Wan; Jonathan Bramson; Frank L Graham; Jack Gauldie
A double recombinant adenovirus expressing the costimulatory molecule B7-1 (murine) and human IL-2 induces complete tumor regression in a murine breast adenocarcinoma model.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2531-8.
1998: Robert Marr; Mary Hitt; William J Muller; Jack Gauldie; Frank L Graham
Tumour therapy in mice using adenovirus vectors expressing human TNFa.
International journal of oncology 1998;12(3):509-15.
1998: A Keith Stewart; A D Schimmer; Denis J Bailey; Ian D Dubé; D Cappe; RC Moen; Jack Gauldie; F L Graham
In vivo adenoviral-mediated gene transfer of interleukin-2 in cutaneous plasmacytoma.
Blood 1998;91(3):1095-7.
1998: Zhou Xing; Jack Gauldie; G Cox; H Baumann; Manel Jordana; XF Lei; M K Achong
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.
The Journal of clinical investigation 1998;101(2):311-20.
1998: G M Tremblay; Jamila Chakir; Louis-Philippe Boulet; Manel Jordana; Carl D Richards; Jack Gauldie
Bronchial myofibroblasts and tissue remodelling in asthma.
Canadian respiratory journal : journal of the Canadian Thoracic Society 1998;5(1):59-61.
1997: Zhou Xing; Jack Gauldie; G M Tremblay; Bryan Hewlett; CL Addison
Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis.
Laboratory investigation; a journal of technical methods and pathology 1997;77(6):615-22.
1997: Cory M Hogaboam; Bruce A Vallance; A Kumar; CL Addison; Frank L Graham; Jack Gauldie; Stephen Collins
Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease.
The Journal of clinical investigation 1997;100(11):2766-76.
1997: Robert Marr; CL Addison; Denis Snider; William J Muller; Jack Gauldie; Frank L Graham
Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNF alpha.
Gene therapy 1997;4(11):1181-8.
1997: David A Zisman; Steven Kunkel; Robert M Strieter; Jack Gauldie; Wan C Tsai; J Bramson; Jodi Wilkowski; KA Bucknell; Theodore J Standiford
Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs bacterial clearance in murine Escherichia coli peritoneal sepsis.
Shock (Augusta, Ga.) 1997;8(5):349-56.
1997: Jonathan Bramson; Mary Hitt; Jack Gauldie; Frank L Graham
Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination.
Gene therapy 1997;4(10):1069-76.
1997: B M Pützer; Mary Hitt; William J Muller; Peter C R Emtage; Jack Gauldie; Frank L Graham
Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10889-94.
1997: Patricia J Sime; Zhou Xing; Frank L Graham; K G Csaky; Jack Gauldie
Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.
The Journal of clinical investigation 1997;100(4):768-76.
1997: V Thibault; B Terlain; Frank L Graham; Jack Gauldie
Construction and characterization of a replication-deficient adenovirus expressing rat-soluble interleukin-6 receptor.
Molecular medicine (Cambridge, Mass.) 1997;3(8):519-29.
1997: A Keith Stewart; Norman Lassam; FL Graham; Jack Gauldie; CL Addison; Denis J Bailey; S Dessureault; Ian D Dubé; S Gallenger; M Krajden; Lorne Rotstein; IC Quirt; RC Moen
A phase I study of adenovirus mediated gene transfer of interleukin 2 cDNA into metastatic breast cancer or melanoma.
Human gene therapy 1997;8(11):1403-14.
1997: Yonghong Wan; Jonathan Bramson; R Carter; F Graham; Jack Gauldie
Dendritic cells transduced with an adenoviral vector encoding a model tumor-associated antigen for tumor vaccination.
Human gene therapy 1997;8(11):1355-63.
1997: Jean-Michel Sallenave; Mustapha Si-Tahar; G Cox; Michel Chignard; Jack Gauldie
Secretory leukocyte proteinase inhibitor is a major leukocyte elastase inhibitor in human neutrophils.
Journal of leukocyte biology 1997;61(6):695-702.
1997: Jean-Michel Sallenave; G M Tremblay; Jack Gauldie; Carl D Richards
Oncostatin M, but not interleukin-6 or leukemia inhibitory factor, stimulates expression of alpha1-proteinase inhibitor in A549 human alveolar epithelial cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(6):337-46.
1997: Patricia J Sime; B Sarnstrand; Zhou Xing; F Graham; L Fisher; Jack Gauldie
Adenovirus-mediated gene transfer of the proteoglycan biglycan induces fibroblastic responses in the lung.
Chest 1997;111(6 Suppl):137S.
1997: Jean-Michel Sallenave; Zhou Xing; F Graham; Jack Gauldie
In vivo adenovirus-mediated expression of human pre-elafin, a potent neutrophil elastase inhibitor.
Chest 1997;111(6 Suppl):128S-129S.
1997: Patricia J Sime; Zhou Xing; R Foley; F L Graham; Jack Gauldie
Transient gene transfer and expression in the lung.
Chest 1997;111(6 Suppl):89S-94S.
1997: V Thibault; Carl D Richards; FM Botelho; Jack Gauldie
Antibodies to rat soluble IL-6 receptor stimulate B9 hybridoma cell proliferation.
FEBS letters 1997;408(2):182-6.
1997: Nicholas W Lukacs; CL Addison; Jack Gauldie; F Graham; K Simpson; Robert M Strieter; KS Warmington; Stephen W Chensue; Steven Kunkel
Transgene-induced production of IL-4 alters the development and collagen expression of T helper cell 1-type pulmonary granulomas.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4478-84.
1997: Peter Vadas; B Grouix; E Stefanski; M Wloch; Waldemar Pruzanski; J Schroeder; Jack Gauldie
Coordinate expression of group II phospholipase A2 and the acute-phase proteins haptoglobin (HP) and alpha1-anti-chymotrypsin (ACH) by HepG2 cells.
Clinical and experimental immunology 1997;108(1):175-80.
1997: Ronan Foley; R Ellis; Irwin Walker; Yonghong Wan; R Carter; M Boyle; Todd A Braciak; CL Addison; F Graham; Jack Gauldie
Intramarrow cytokine gene transfer by adenoviral vectors in dogs.
Human gene therapy 1997;8(5):545-53.
1997: Zhou Xing; Y Ohkawara; Manel Jordana; Frank L Graham; Jack Gauldie
Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia.
Gene therapy 1997;4(2):140-9.
1997: B Sakić; Henry Szechtman; Todd A Braciak; C Richards; Jack Gauldie; Judah A Denburg
Reduced preference for sucrose in autoimmune mice: a possible role of interleukin-6.
Brain research bulletin 1997;44(2):155-65.
1997: Zhou Xing; G M Tremblay; Patricia J Sime; Jack Gauldie
Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation.
The American journal of pathology 1997;150(1):59-66.
1996: Todd A Braciak; K Bacon; Zhou Xing; D J Torry; F L Graham; T J Schall; Carl D Richards; Kenneth Croitoru; Jack Gauldie
Overexpression of RANTES using a recombinant adenovirus vector induces the tissue-directed recruitment of monocytes to the lung.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5076-84.
1996: V Thibault; B Terlain; Jack Gauldie
Characterization and biologic activities of recombinant rat soluble interleukin-6 receptor.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(11):973-81.
1996: Jack Gauldie; F Graham; Zhou Xing; Todd A Braciak; Ronan Foley; Patricia J Sime
Adenovirus-vector-mediated cytokine gene transfer to lung tissue.
Annals of the New York Academy of Sciences 1996;796():235-44.
1996: Jonathan Bramson; Mary Hitt; CL Addison; William J Muller; Jack Gauldie; F L Graham
Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12.
Human gene therapy 1996;7(16):1995-2002.
1996: G M Tremblay; Jean-Michel Sallenave; E Israél-Assayag; Y Cormier; Jack Gauldie
Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung.
American journal of respiratory and critical care medicine 1996;154(4 Pt 1):1092-8.
1996: Ronan Foley; Kevin E Driscoll; Yonghong Wan; Todd A Braciak; B Howard; Zhou Xing; F Graham; Jack Gauldie
Adenoviral gene transfer of macrophage inflammatory protein-2 in rat lung.
The American journal of pathology 1996;149(4):1395-403.
1996: M J Greenberger; Steven Kunkel; Robert M Strieter; Nicholas W Lukacs; Jonathan Bramson; Jack Gauldie; F L Graham; Mary Hitt; J M Danforth; Theodore J Standiford
IL-12 gene therapy protects mice in lethal Klebsiella pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):3006-12.
1996: Todd A Braciak; W Northemann; D K Chong; J A Schroeder; Jack Gauldie
Vector-derived expression of recombinant rat interleukin-6.
Protein expression and purification 1996;7(3):269-74.
1996: M Geisterfer; Jack Gauldie
Regulation of signal transducer, GP13O and the LIF receptor in acute inflammation in vivo.
Cytokine 1996;8(4):283-7.
1996: Zhou Xing; Todd A Braciak; Y Ohkawara; Jean-Michel Sallenave; Ronan Foley; Patricia J Sime; Manel Jordana; F L Graham; Jack Gauldie
Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation.
Journal of leukocyte biology 1996;59(4):481-8.
1996: D J Torry; Carl D Richards; Thomas J Podor; Jack Gauldie
Modulation of the anchorage-independent phenotype of human lung fibroblasts obtained from fibrotic tissue following culture with retinoid and corticosteroid.
Experimental lung research 1996;22(2):231-44.
1996: Zhou Xing; Y Ohkawara; Manel Jordana; F Graham; Jack Gauldie
Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.
The Journal of clinical investigation 1996;97(4):1102-10.
1996: Jonathan Bramson; Mary Hitt; WS Gallichan; Kenneth L Rosenthal; Jack Gauldie; F L Graham
Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: in vitro and in vivo production of biologically active interleukin-12.
Human gene therapy 1996;7(3):333-42.
1996: Carl D Richards; Carrie M Langdon; D Pennica; Jack Gauldie
Murine cardiotrophin-1 stimulates the acute-phase response in rat hepatocytes and H35 hepatoma cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(1):69-75.
1995: Jonathan Bramson; F L Graham; Jack Gauldie
The use of adenoviral vectors for gene therapy and gene transfer in vivo.
Current opinion in biotechnology 1995;6(5):590-5.
1995: D Seiffert; M Geisterfer; Jack Gauldie; Edward Young; Thomas J Podor
IL-6 stimulates vitronectin gene expression in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(6):3180-5.
1995: CL Addison; Todd A Braciak; R Ralston; William J Muller; Jack Gauldie; F L Graham
Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8522-6.
1995: M Geisterfer; Carl D Richards; Jack Gauldie
Cytokines oncostatin M and interleukin 1 regulate the expression of the IL-6 receptor (gp80, gp130).
Cytokine 1995;7(6):503-9.
1995: Carl D Richards; Todd A Braciak; Zhou Xing; F Graham; Jack Gauldie
Adenovirus vectors for cytokine gene expression.
Annals of the New York Academy of Sciences 1995;762():282-92; discussion 292-3.
1994: Jean-Michel Sallenave; J Shulmann; J Crossley; Manel Jordana; Jack Gauldie
Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes.
American journal of respiratory cell and molecular biology 1994;11(6):733-41.
1994: Zhou Xing; Todd A Braciak; Manel Jordana; Kenneth Croitoru; F L Graham; Jack Gauldie
Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):4059-69.
1994: S Finotto; I Ohno; Jean S Marshall; Jack Gauldie; Judah A Denburg; Jerry Dolovich; David A Clark; Manel Jordana
TNF-alpha production by eosinophils in upper airways inflammation (nasal polyposis).
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2278-89.
1994: V A Wallace; S Kondo; T Kono; Zhou Xing; E Timms; Caren Furlonger; E Keystone; Jack Gauldie; Daniel N Sauder; Tak W Mak
A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice.
European journal of immunology 1994;24(6):1463-6.
1994: Jack Gauldie; G Cox; Manel Jordana; I Ohno; Haresh Kirpalani
Growth and colony-stimulating factors mediate eosinophil fibroblast interactions in chronic airway inflammation.
Annals of the New York Academy of Sciences 1994;725():83-90.
1994: D J Torry; Carl D Richards; Thomas J Podor; Jack Gauldie
Anchorage-independent colony growth of pulmonary fibroblasts derived from fibrotic human lung tissue.
The Journal of clinical investigation 1994;93(4):1525-32.
1994: Zhou Xing; Manel Jordana; Haresh Kirpalani; Kevin E Driscoll; T J Schall; Jack Gauldie
Cytokine expression by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha, macrophage inflammatory protein-2, interleukin-1 beta, and interleukin-6 but not RANTES or transforming growth factor-beta 1 mRNA expression in acute lung inflammation.
American journal of respiratory cell and molecular biology 1994;10(2):148-53.
1993: Todd A Braciak; S K Mittal; F L Graham; Carl D Richards; Jack Gauldie
Construction of recombinant human type 5 adenoviruses expressing rodent IL-6 genes. An approach to investigate in vivo cytokine function.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5145-53.
1993: Zhou Xing; Haresh Kirpalani; D Torry; Manel Jordana; Jack Gauldie
Polymorphonuclear leukocytes as a significant source of tumor necrosis factor-alpha in endotoxin-challenged lung tissue.
The American journal of pathology 1993;143(4):1009-15.
1993: Zhou Xing; Manel Jordana; Todd A Braciak; T Ohtoshi; Jack Gauldie
Lipopolysaccharide induces expression of granulocyte/macrophage colony-stimulating factor, interleukin-8, and interleukin-6 in human nasal, but not lung, fibroblasts: evidence for heterogeneity within the respiratory tract.
American journal of respiratory cell and molecular biology 1993;9(3):255-63.
1993: J S Marshall; Jack Gauldie; L Nielsen; John Bienenstock
Leukemia inhibitory factor production by rat mast cells.
European journal of immunology 1993;23(9):2116-20.
1993: Carl D Richards; M Shoyab; T J Brown; Jack Gauldie
Selective regulation of metalloproteinase inhibitor (TIMP-1) by oncostatin M in fibroblasts in culture.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(12):5596-603.
1993: M Geisterfer; C Richards; M Baumann; G Fey; D Gywnne; Jack Gauldie
Regulation of IL-6 and the hepatic IL-6 receptor in acute inflammation in vivo.
Cytokine 1993;5(1):1-7.
1993: Thomas J Podor; J Hirsh; Thomas D Gelehrter; R Zeheb; D Torry; Yves Guigoz; F Sierra; Jack Gauldie
Type 1 plasminogen activator inhibitor is not an acute phase reactant in rats. Lack of IL-6- and hepatocyte-dependent synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):225-35.
1992: Thomas J Podor; P Joshua; M Butcher; D Seiffert; D Loskutoff; Jack Gauldie
Accumulation of type 1 plasminogen activator inhibitor and vitronectin at sites of cellular necrosis and inflammation.
Annals of the New York Academy of Sciences 1992;667():173-7.
1992: F Sierra; S Coeytaux; M Juillerat; C Ruffieux; Jack Gauldie; Yves Guigoz
Serum T-kininogen levels increase shortly before death.
Annals of the New York Academy of Sciences 1992;663():479-80.
1992: G Cox; Jack Gauldie; Manel Jordana
Bronchial epithelial cell-derived cytokines (G-CSF and GM-CSF) promote the survival of peripheral blood neutrophils in vitro.
American journal of respiratory cell and molecular biology 1992;7(5):507-13.
1992: Jack Gauldie; C Richards; H Baumann
IL6 and the acute phase reaction.
Research in immunology 1992;143(7):755-9.
1992: F Sierra; S Coeytaux; M Juillerat; C Ruffieux; Jack Gauldie; Yves Guigoz
Serum T-kininogen levels increase two to four months before death.
The Journal of biological chemistry 1992;267(15):10665-9.
1992: I Ohno; R G Lea; K C Flanders; David A Clark; D Banwatt; Jerry Dolovich; J Denburg; C B Harley; Jack Gauldie; Manel Jordana
Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1).
The Journal of clinical investigation 1992;89(5):1662-8.
1992: Carl D Richards; T J Brown; M Shoyab; H Baumann; Jack Gauldie
Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1731-6.
1992: Jack Gauldie; Manel Jordana; G Cox; T Ohtoshi; Jerry Dolovich; J Denburg
Fibroblasts and other structural cells in airway inflammation.
The American review of respiratory disease 1992;145(2 Pt 2):S14-7.
1992: Zhou Xing; T Ohtoshi; P Ralph; Jack Gauldie; Manel Jordana
Human upper airway structural cell-derived cytokines support human peripheral blood monocyte survival: a potential mechanism for monocyte/macrophage accumulation in the tissue.
American journal of respiratory cell and molecular biology 1992;6(2):212-8.
1991: I Ohno; R Lea; S Finotto; J Marshall; J Denburg; Jerry Dolovich; Jack Gauldie; Manel Jordana
Granulocyte/macrophage colony-stimulating factor (GM-CSF) gene expression by eosinophils in nasal polyposis.
American journal of respiratory cell and molecular biology 1991;5(6):505-10.
1991: G Cox; T Ohtoshi; Carlo Vancheri; Judah A Denburg; Jerry Dolovich; Jack Gauldie; Manel Jordana
Promotion of eosinophil survival by human bronchial epithelial cells and its modulation by steroids.
American journal of respiratory cell and molecular biology 1991;4(6):525-31.
1991: C Richards; Jack Gauldie; H Baumann
Cytokine control of acute phase protein expression.
European cytokine network 1991;2(2):89-98.
1991: T Ohtoshi; Carlo Vancheri; G Cox; Jack Gauldie; Jerry Dolovich; Judah A Denburg; Manel Jordana
Monocyte-macrophage differentiation induced by human upper airway epithelial cells.
American journal of respiratory cell and molecular biology 1991;4(3):255-63.
1991: T Ohtoshi; T Tsuda; Carlo Vancheri; J S Abrams; Jack Gauldie; Jerry Dolovich; Judah A Denburg; Manel Jordana
Human upper airway epithelial cell-derived granulocyte-macrophage colony-stimulating factor induces histamine-containing cell differentiation of human progenitor cells.
International archives of allergy and applied immunology 1991;95(4):376-84.
1991: Judah A Denburg; Jack Gauldie; Jerry Dolovich; T Ohtoshi; G Cox; Manel Jordana
Structural cell-derived cytokines in allergic inflammation.
International archives of allergy and applied immunology 1991;94(1-4):127-32.
1991: Carlo Vancheri; T Ohtoshi; G Cox; A Xaubet; J S Abrams; Jack Gauldie; Jerry Dolovich; J Denburg; Manel Jordana
Neutrophilic differentiation induced by human upper airway fibroblast-derived granulocyte/macrophage colony-stimulating factor (GM-CSF).
American journal of respiratory cell and molecular biology 1991;4(1):11-7.
1990: Jack Gauldie; W Northemann; G H Fey
IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3804-8.
1989: Carlo Vancheri; Jack Gauldie; John Bienenstock; G Cox; R Scicchitano; A Stanisz; Manel Jordana
Human lung fibroblast-derived granulocyte-macrophage colony stimulating factor (GM-CSF) mediates eosinophil survival in vitro.
American journal of respiratory cell and molecular biology 1989;1(4):289-95.
1989: P Sestini; Myrna B Dolovich; Carlo Vancheri; RH Stead; Jean S Marshall; M Perdue; Jack Gauldie; John Bienenstock
Antigen-induced lung solute clearance in rats is dependent on capsaicin-sensitive nerves.
The American review of respiratory disease 1989;139(2):401-6.
1989: Manel Jordana; Carlo Vancheri; T Ohtoshi; D Harnish; Jack Gauldie; Jerry Dolovich; J Denburg
Hemopoietic function of the microenvironment in chronic airway inflammation.
Agents and actions. Supplements 1989;28():85-95.
1989: Jack Gauldie; C Richards; W Northemann; G Fey; H Baumann
IFN beta 2/BSF2/IL-6 is the monocyte-derived HSF that regulates receptor-specific acute phase gene regulation in hepatocytes.
Annals of the New York Academy of Sciences 1989;557():46-58; discussion 58-9.
1988: Manel Jordana; Myrna B Dolovich; L B Irving; M Tomioka; D Befus; Jack Gauldie; Michael T Newhouse
Solute movement across the alveolar-capillary membrane after intratracheally administered bleomycin in rats.
The American review of respiratory disease 1988;138(1):96-100.
1988: Manel Jordana; C Richards; L B Irving; Jack Gauldie
Spontaneous in vitro release of alveolar-macrophage cytokines after the intratracheal instillation of bleomycin in rats. Characterization and kinetic studies.
The American review of respiratory disease 1988;137(5):1135-40.
1988: Manel Jordana; J Schulman; C McSharry; L B Irving; Michael T Newhouse; G Jordana; Jack Gauldie
Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue.
The American review of respiratory disease 1988;137(3):579-84.
1987: Jack Gauldie; C Richards; D Harnish; P Lansdorp; H Baumann
Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7251-5.
1987: John Bienenstock; M Tomioka; RH Stead; P Ernst; Manel Jordana; Jack Gauldie; Jerry Dolovich; J Denburg
Mast cell involvement in various inflammatory processes.
The American review of respiratory disease 1987;135(6 Pt 2):S5-8.