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Carlotta Gauna

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Chemicals & Drugs

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Patric J D Delhanty; Anke van Kerkwijk; Martin Huisman; Bedette van de Zande; Miriam Verhoef-Post; Carlotta Gauna; Leo Hofland; Axel P N Themmen; Aart Jan Van der Lely
Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization.
Riccarda Granata; Marco Volante; Fabio Settanni; Carlotta Gauna; Corrado Ghé; Marta Annunziata; Barbara Deidda; Iacopo Gesmundo; Thierry Abribat; Aart Jan Van der Lely; Giampiero Muccioli; Ezio Ghigo; Mauro Papotti
Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats.
Rosalie M Kiewiet; Carlotta Gauna; Maarten O van Aken; Bedette van de Zande; Aart Jan Van der Lely
Bolus administration of obestatin does not change glucose and insulin levels neither in the systemic nor in the portal circulation of the rat.

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All Publications

2010: Patric J D Delhanty; Anke van Kerkwijk; Martin Huisman; Bedette van de Zande; Miriam Verhoef-Post; Carlotta Gauna; Leo Hofland; Axel P N Themmen; Aart Jan Van der Lely
Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization.
American journal of physiology. Endocrinology and metabolism 2010;299(3):E497-505.
2010: Riccarda Granata; Marco Volante; Fabio Settanni; Carlotta Gauna; Corrado Ghé; Marta Annunziata; Barbara Deidda; Iacopo Gesmundo; Thierry Abribat; Aart Jan Van der Lely; Giampiero Muccioli; Ezio Ghigo; Mauro Papotti
Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats.
Journal of molecular endocrinology 2010;45(1):9-17.
2008: Rosalie M Kiewiet; Carlotta Gauna; Maarten O van Aken; Bedette van de Zande; Aart Jan Van der Lely
Bolus administration of obestatin does not change glucose and insulin levels neither in the systemic nor in the portal circulation of the rat.
Peptides 2008;29(12):2144-9.
2007: Carlotta Gauna; Piet Uitterlinden; Piet Kramer; Rosalie M Kiewiet; Joop A M J L Janssen; Patric J D Delhanty; Maarten O van Aken; Ezio Ghigo; Leo J Hofland; Axel P N Themmen; Aart Jan Van der Lely
Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats.
Endocrinology 2007;148(11):5278-87.
2007: Carlotta Gauna; Rosalie M Kiewiet; Joop A M J L Janssen; Bedette van de Zande; Patric J D Delhanty; Ezio Ghigo; Leo J Hofland; Axel P N Themmen; Aart Jan Van der Lely
Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E697-704.
2007: Carlotta Gauna; Bedette van de Zande; Anke van Kerkwijk; Axel P N Themmen; Aart Jan Van der Lely; Patric J D Delhanty
Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).
Molecular and cellular endocrinology 2007;274(1-2):30-4.
2007: Patric J D Delhanty; Peter M Van Koetsveld; Carlotta Gauna; Bedette van de Zande; Giovanni Vitale; Leo J Hofland; Aart Jan Van der Lely
Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E302-9.
2006: Carlotta Gauna; Patric J D Delhanty; Maarten O van Aken; Joop A M J L Janssen; Axel P N Themmen; Leo J Hofland; Michael Culler; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor.
Molecular and cellular endocrinology 2006;251(1-2):103-11.
2006: Patric J D Delhanty; B C J van der Eerden; M van der Velde; Carlotta Gauna; Huibert A P Pols; Holger Jahr; H Chiba; Aart Jan Van der Lely; Johannes P T M van Leeuwen
Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a.
The Journal of endocrinology 2006;188(1):37-47.
2005: Carlotta Gauna; Patric J D Delhanty; Leo J Hofland; Joop A M J L Janssen; Fabio Broglio; Richard J M Ross; Ezio Ghigo; Aart Jan Van der Lely
Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes.
The Journal of clinical endocrinology and metabolism 2005;90(2):1055-60.
2005: Carlotta Gauna; Aart Jan Van der Lely
Somatostatin, cortistatin, ghrelin and glucose metabolism.
Journal of endocrinological investigation 2005;28(11 Suppl International):127-31.
2005: Carlotta Gauna; Greet Van den Berghe; Aart Jan Van der Lely
Pituitary function during severe and life-threatening illnesses.
Pituitary 2005;8(3-4):213-7.
2004: Cristina Gottero; Fabio Broglio; Flavia Prodam; Silvia Destefanis; Simonetta Bellone; Andrea Benso; Carlotta Gauna; Emanuela Arvat; Aart Jan Van der Lely; Ezio Ghigo
Ghrelin: a link between eating disorders, obesity and reproduction.
Nutritional neuroscience 2004;7(5-6):255-70.
2004: Fabio Broglio; Cristina Gottero; Flavia Prodam; Silvia Destefanis; Carlotta Gauna; Elisa Me; Fabrizio Riganti; Daniela Vivenza; Anna Rapa; Valentino Martina; Emanuela Arvat; Gianni Bona; Aart Jan Van der Lely; Ezio Ghigo
Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans.
Clinical endocrinology 2004;61(4):503-9.
2004: Carlotta Gauna; F M Meyler; Joop A M J L Janssen; Patric J D Delhanty; T Abribat; Peter M Van Koetsveld; Leo J Hofland; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
The Journal of clinical endocrinology and metabolism 2004;89(10):5035-42.
2004: Cristina Gottero; Flavia Prodam; Silvia Destefanis; Andrea Benso; Carlotta Gauna; Elisa Me; L Filtri; Fabrizio Riganti; Aart Jan Van der Lely; Ezio Ghigo; Fabio Broglio
Cortistatin-17 and -14 exert the same endocrine activities as somatostatin in humans.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2004;14(5):382-7.
2004: Fabio Broglio; Cristina Gottero; Flavia Prodam; Carlotta Gauna; Giampiero Muccioli; M Papotti; T Abribat; Aart Jan Van der Lely; Ezio Ghigo
Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.
The Journal of clinical endocrinology and metabolism 2004;89(6):3062-5.
2004: Fabio Broglio; Cristina Gottero; Peter M Van Koetsveld; Flavia Prodam; Silvia Destefanis; Andrea Benso; Carlotta Gauna; Leo J Hofland; Emanuela Arvat; Aart Jan Van der Lely; Ezio Ghigo
Acetylcholine regulates ghrelin secretion in humans.
The Journal of clinical endocrinology and metabolism 2004;89(5):2429-33.
2004: Fabio Broglio; Laura Gianotti; Silvia Destefanis; Secondo Fassino; Giovanni Abbate-Daga; Valeria Mondelli; Fabio Lanfranco; Cristina Gottero; Carlotta Gauna; Leo J Hofland; Aart Jan Van der Lely; Ezio Ghigo
The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state.
Clinical endocrinology 2004;60(5):592-9.
2003: Cristina Gottero; Simonetta Bellone; Anna Rapa; Peter M Van Koetsveld; Daniela Vivenza; Flavia Prodam; Andrea Benso; Silvia Destefanis; Carlotta Gauna; Jaele Bellone; Leo J Hofland; Aart Jan Van der Lely; Gianni Bona; Ezio Ghigo; Fabio Broglio
Standard light breakfast inhibits circulating ghrelin level to the same extent of oral glucose load in humans, despite different impact on glucose and insulin levels.
Journal of endocrinological investigation 2003;26(12):1203-7.
2003: Francesco Tassone; Fabio Broglio; Silvia Destefanis; Silvia Rovere; Andrea Benso; Cristina Gottero; Flavia Prodam; Ruth Rossetto; Carlotta Gauna; Aart Jan Van der Lely; Ezio Ghigo; Mauro Maccario
Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity.
The Journal of clinical endocrinology and metabolism 2003;88(11):5478-83.
2003: Fabio Broglio; Cristina Gottero; Andrea Benso; Flavia Prodam; Marco Volante; Silvia Destefanis; Carlotta Gauna; Giampiero Muccioli; Mauro Papotti; Aart Jan Van der Lely; Ezio Ghigo
Ghrelin and the endocrine pancreas.
Endocrine 2003;22(1):19-24.
2003: Fabio Broglio; Cristina Gottero; Andrea Benso; Flavia Prodam; Silvia Destefanis; Carlotta Gauna; Mauro Maccario; Romano Deghenghi; Aart Jan Van der Lely; Ezio Ghigo
Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans.
The Journal of clinical endocrinology and metabolism 2003;88(9):4268-72.
2003: Andrea Benso; Cristina Gottero; Flavia Prodam; Carlotta Gauna; Silvia Destefanis; L Filtri; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo; Fabio Broglio
Effects of cortistatin-14 and somatostatin-14 on the endocrine response to hexarelin in humans.
Journal of endocrinological investigation 2003;26(7):599-603.
2003: Fabio Broglio; Andrea Benso; Carlotta Castiglioni; Cristina Gottero; Flavia Prodam; Silvia Destefanis; Carlotta Gauna; Aart Jan Van der Lely; Romano Deghenghi; Mario Bo; Emanuela Arvat; Ezio Ghigo
The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects.
The Journal of clinical endocrinology and metabolism 2003;88(4):1537-42.
2003: Fabio Broglio; Andrea Benso; Cristina Gottero; Flavia Prodam; Carlotta Gauna; L Filtri; Emanuela Arvat; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo
Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans.
Journal of endocrinological investigation 2003;26(3):192-6.
2003: Silvia Grottoli; Carlotta Gauna; Francesco Tassone; Gianluca Aimaretti; Ginevra Corneli; Z Wu; Christian J Strasburger; Carlos Dieguez; Felipe F Casanueva; Ezio Ghigo; Mauro Maccario
Both fasting-induced leptin reduction and GH increase are blunted in Cushing's syndrome and in simple obesity.
Clinical endocrinology 2003;58(2):220-8.
2002: Laura Gianotti; Sonia Pivetti; Fabio Lanfranco; Francesco Tassone; Fabrizia Navone; E Vittori; Ruth Rossetto; Carlotta Gauna; Silvia Destefanis; Silvia Grottoli; R De Giorgi; Valerio Gai; Ezio Ghigo; Mauro Maccario
Concomitant impairment of growth hormone secretion and peripheral sensitivity in obese patients with obstructive sleep apnea syndrome.
The Journal of clinical endocrinology and metabolism 2002;87(11):5052-7.
2002: Fabio Broglio; Peter van Koetsveld Pv; Andrea Benso; Cristina Gottero; Flavia Prodam; Mauro Papotti; Giampiero Muccioli; Carlotta Gauna; Leo J Hofland; Romano Deghenghi; Emanuela Arvat; Aart Jan Van der Lely; Ezio Ghigo
Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans.
The Journal of clinical endocrinology and metabolism 2002;87(10):4829-32.
2002: Francesco Tassone; Silvia Grottoli; Ruth Rossetto; B Maccagno; Carlotta Gauna; Roberta Giordano; Ezio Ghigo; Mauro Maccario
Glucagon administration elicits blunted GH but exaggerated ACTH response in obesity.
Journal of endocrinological investigation 2002;25(6):551-6.
2002: Mauro Maccario; Francesco Tassone; Silvia Grottoli; Ruth Rossetto; Carlotta Gauna; Ezio Ghigo
Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-I axis to obesity.
Annales d'endocrinologie 2002;63(2 Pt 1):140-4.
2002: Francesco Tassone; Ruth Rossetto; Carlotta Gauna; Massimo Procopio; Silvia Grottoli; L Ausiello; Marina Taliano; Mauro Maccario
Age-related endocrine and metabolic changes in simple obesity.
Journal of endocrinological investigation 2002;25(10 Suppl):106.
2002: Riccarda Granata; Carlotta Gauna; E Arnolfo; D Atragene; Fabio Broglio; Renata Ponti; Emanuela Ricotti; Ezio Ghigo
H9c2 cardiac muscle cells express insulin-like growth factor binding protein-3 (IGFBP-3).
Journal of endocrinological investigation 2002;25(10 Suppl):44-6.
2001: Mauro Maccario; Gianluca Aimaretti; Silvia Grottoli; Carlotta Gauna; Francesco Tassone; Ginevra Corneli; Ruth Rossetto; Z Wu; Christian J Strasburger; Ezio Ghigo
Effects of 36 hour fasting on GH/IGF-I axis and metabolic parameters in patients with simple obesity. Comparison with normal subjects and hypopituitary patients with severe GH deficiency.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(8):1233-9.
2001: Mauro Maccario; Francesco Tassone; Carlotta Gauna; SE Oleandri; Gianluca Aimaretti; Massimo Procopio; Silvia Grottoli; CD Pflaum; Christian J Strasburger; Ezio Ghigo
Effects of short-term administration of low-dose rhGH on IGF-I levels in obesity and Cushing's syndrome: indirect evaluation of sensitivity to GH.
European journal of endocrinology / European Federation of Endocrine Societies 2001;144(3):251-6.
2000: Mauro Maccario; Gianluca Aimaretti; Ginevra Corneli; Carlotta Gauna; Silvia Grottoli; Martin Bidlingmaier; Christian J Strasburger; Carlos Dieguez; Felipe F Casanueva; Ezio Ghigo
Short-term fasting abolishes the sex-related difference in GH and leptin secretion in humans.
American journal of physiology. Endocrinology and metabolism 2000;279(2):E411-6.
2000: Silvia Grottoli; Emanuela Arvat; Carlotta Gauna; B Maccagno; Josefina Ramunni; Roberta Giordano; Mauro Maccario; Romano Deghenghi; Ezio Ghigo
Alprazolam, a benzodiazepine, blunts but does not abolish the ACTH and cortisol response to hexarelin, a GHRP, in obese patients.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 2():S136-7.
2000: Mauro Maccario; Silvia Grottoli; Massimo Procopio; SE Oleandri; Ruth Rossetto; Carlotta Gauna; Emanuela Arvat; Ezio Ghigo
The GH/IGF-I axis in obesity: influence of neuro-endocrine and metabolic factors.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 2():S96-9.
1999: Silvia Grottoli; Emanuela Arvat; Carlotta Gauna; B Maccagno; Josefina Ramunni; Roberta Giordano; Mauro Maccario; Romano Deghenghi; Ezio Ghigo
Effects of alprazolam, a benzodiazepine, on the ACTH-, GH- and PRL-releasing activity of hexarelin, a synthetic peptidyl GH secretagogue (GHS), in patients with simple obesity and in patients with Cushing's disease.
Pituitary 1999;2(3):197-204.
1999: E Mazza; M Maccario; Josefina Ramunni; Carlotta Gauna; A Bertagna; A M Barberis; S Patroncini; M Messina; E Ghigo
Dehydroepiandrosterone sulfate levels in women. Relationships with age, body mass index and insulin levels.
Journal of endocrinological investigation 1999;22(9):681-7.
1999: Mauro Maccario; Carlotta Gauna; Massimo Procopio; Lidia Di Vito; Ruth Rossetto; SE Oleandri; Silvia Grottoli; Chiara Ganzaroli; Gianluca Aimaretti; Ezio Ghigo
Assessment of GH/IGF-I axis in obesity by evaluation of IGF-I levels and the GH response to GHRH+arginine test.
Journal of endocrinological investigation 1999;22(6):424-9.
1999: Mauro Maccario; E Mazza; Josefina Ramunni; SE Oleandri; P Savio; Silvia Grottoli; Ruth Rossetto; Massimo Procopio; Carlotta Gauna; Ezio Ghigo
Relationships between dehydroepiandrosterone-sulphate and anthropometric, metabolic and hormonal variables in a large cohort of obese women.
Clinical endocrinology 1999;50(5):595-600.
1999: SE Oleandri; Mauro Maccario; Ruth Rossetto; Massimo Procopio; Silvia Grottoli; Enrico Avogadri; Carlotta Gauna; Chiara Ganzaroli; Ezio Ghigo
Three-month treatment with metformin or dexfenfluramine does not modify the effects of diet on anthropometric and endocrine-metabolic parameters in abdominal obesity.
Journal of endocrinological investigation 1999;22(2):134-40.
1998: Laura Gianotti; Fabio Broglio; Josefina Ramunni; Fabio Lanfranco; Carlotta Gauna; Andrea Benso; M Zanello; Emanuela Arvat; Ezio Ghigo
The activity of GH/IGF-I axis in anorexia nervosa and in obesity: a comparison with normal subjects and patients with hypopituitarism or critical illness.
Eating and weight disorders : EWD 1998;3(2):64-70.