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Evripidis Gavathiotis

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Nicole A Cohen; Evripidis Gavathiotis; Brian Koss; Joseph T Opferman; Michelle L Stewart; Jared L Tepper; Susanne R Bruekner; Loren D Walensky
A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.
Evripidis Gavathiotis; Elizaveta S Leshchiner; Denis E Reyna; Joseph A Bellairs; Loren D Walensky
Direct and selective small-molecule activation of proapoptotic BAX.
James L LaBelle; Chelsea Lawrence; Kenneth Pitter; Michelle L Stewart; Gregory H Bird; Jill K Fisher; Evripidis Gavathiotis; Marina Godes; Samuel G Katz; Andrew L Kung; Loren D Walensky
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

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2012: Nicole A Cohen; Evripidis Gavathiotis; Brian Koss; Joseph T Opferman; Michelle L Stewart; Jared L Tepper; Susanne R Bruekner; Loren D Walensky
A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.
Chemistry & biology 2012;19(9):1175-86.
2012: Evripidis Gavathiotis; Elizaveta S Leshchiner; Denis E Reyna; Joseph A Bellairs; Loren D Walensky
Direct and selective small-molecule activation of proapoptotic BAX.
Nature chemical biology 2012;8(7):639-45.
2012: James L LaBelle; Chelsea Lawrence; Kenneth Pitter; Michelle L Stewart; Gregory H Bird; Jill K Fisher; Evripidis Gavathiotis; Marina Godes; Samuel G Katz; Andrew L Kung; Loren D Walensky
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.
The Journal of clinical investigation 2012;122(6):2018-31.
2012: Russell S Whelan; Ying Yang; John W Calvert; Yun Chen; Michael T Crow; Gerald W Dorn; Evripidis Gavathiotis; Saurabh Jha; Klitos Konstantinidis; Tullia Lindsten; Brian O'Rourke; Denis E Reyna; Craig B Thompson; An-Chi Wei; Richard N Kitsis
Bax regulates primary necrosis through mitochondrial dynamics.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6566-71.
2011: Loren D Walensky; Evripidis Gavathiotis
BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore.
Trends in biochemical sciences 2011;36(12):642-52.
2011: Evripidis Gavathiotis; Loren D Walensky
Tracking BAX once its trigger is pulled.
Cell cycle (Georgetown, Tex.) 2011;10(6):868-70.
2010: Craig R Braun; Julian Mintseris; Evripidis Gavathiotis; Gregory H Bird; Steven P Gygi; Loren D Walensky
Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.
Chemistry & biology 2010;17(12):1325-33.
2010: Evripidis Gavathiotis; Denis E Reyna; Marguerite L Davis; Gregory H Bird; Loren D Walensky
BH3-triggered structural reorganization drives the activation of proapoptotic BAX.
Molecular cell 2010;40(3):481-92.
2010: Gregory H Bird; Navid Madani; Alisa F Perry; Amy M Princiotto; Jeffrey G Supko; Xiaoying He; Evripidis Gavathiotis; Joseph G Sodroski; Loren D Walensky
Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14093-8.
2008: Evripidis Gavathiotis; Motoshi Suzuki; Marguerite L Davis; Kenneth Pitter; Gregory H Bird; Samuel G Katz; Ho-Chou Tu; Hyungjin Kim; Emily Cheng; Nico Tjandra; Loren D Walensky
BAX activation is initiated at a novel interaction site.
Nature 2008;455(7216):1076-81.
2006: Paul E Carrington; Cristinel Sandu; Yufeng Wei; Justine M Hill; Gaku Morisawa; Ted Huang; Evripidis Gavathiotis; Yu Wei; Milton H Werner
The structure of FADD and its mode of interaction with procaspase-8.
Molecular cell 2006;22(5):599-610.
2005: Cristinel Sandu; Evripidis Gavathiotis; Ted Huang; Iga N Wegorzewska; Milton H Werner
A mechanism for death receptor discrimination by death adaptors.
The Journal of biological chemistry 2005;280(36):31974-80.
2003: Evripidis Gavathiotis; Robert A Heald; Malcolm F G Stevens; Mark S Searle
Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat.
Journal of molecular biology 2003;334(1):25-36.
2003: Evripidis Gavathiotis; Mark S Searle
Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations.
Organic & biomolecular chemistry 2003;1(10):1650-6.
2001: SA Harris; Evripidis Gavathiotis; Mark S Searle; M Orozco; Charles A Laughton
Cooperativity in drug-DNA recognition: a molecular dynamics study.
Journal of the American Chemical Society 2001;123(50):12658-63.
2000: Evripidis Gavathiotis; Gary J Sharman; Mark S Searle
Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)(2).
Nucleic acids research 2000;28(3):728-35.

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