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Florence Gaven

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Chemicals & Drugs

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Protein Structure, Tertiary

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Florence Gaven; Lucie P Pellissier; Emilie Queffeulou; Joël Bockaert; Maud Cochet; Aline Dumuis; Sylvie Claeysen
Pharmacological profile of engineered 5-HT4 receptors and identification of 5-HT4 receptor-biased ligands.
Maud Cochet; Romain Donneger; Aline Dumuis; Florence Gaven; Stefan F Lichtenthaler; Philippe Marin; Joël Bockaert; Elisabeth Cassier; Sylvie Claeysen
5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.
Julie Meffre; Mark J Millan; Jean-Michel Rivet; Martial Séveno; David J G Watson; Joël Bockaert; Séverine Chaumont-Dubel; Anne Dekeyne; Paul Déléris; Kevin C F Fone; Florence Gaven; Denis Hervé; Florence Loiseau; Clotilde Mannoury La Cour; Philippe Marin
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

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All Publications

2013: Florence Gaven; Lucie P Pellissier; Emilie Queffeulou; Joël Bockaert; Maud Cochet; Aline Dumuis; Sylvie Claeysen
Pharmacological profile of engineered 5-HT4 receptors and identification of 5-HT4 receptor-biased ligands.
Brain research 2013;1511():65-72.
2013: Maud Cochet; Romain Donneger; Aline Dumuis; Florence Gaven; Stefan F Lichtenthaler; Philippe Marin; Joël Bockaert; Elisabeth Cassier; Sylvie Claeysen
5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.
ACS chemical neuroscience 2013;4(1):130-40.
2012: Julie Meffre; Mark J Millan; Jean-Michel Rivet; Martial Séveno; David J G Watson; Joël Bockaert; Séverine Chaumont-Dubel; Anne Dekeyne; Paul Déléris; Kevin C F Fone; Florence Gaven; Denis Hervé; Florence Loiseau; Clotilde Mannoury La Cour; Philippe Marin
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
EMBO molecular medicine 2012;4(10):1043-56.
2011: Lucie P Pellissier; Gaël Barthet; Florence Gaven; Elisabeth Cassier; Eric Trinquet; Jean-Philippe Pin; Philippe Marin; Aline Dumuis; Joël Bockaert; Jean-Louis Banères; Sylvie Claeysen
G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient.
The Journal of biological chemistry 2011;286(12):9985-97.
2009: Gaël Barthet; Gaëlle Carrat; Elizabeth Cassier; Breann Barker; Florence Gaven; Marion Pillot; Bérénice Framery; Lucie P Pellissier; Julie Augier; Dong Soo Kang; Sylvie Claeysen; Eric Reiter; Jean-Louis Banères; Jeffrey L Benovic; Philippe Marin; Joël Bockaert; Aline Dumuis
Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.
The EMBO journal 2009;28(18):2706-18.
2007: Pauline Sibille; Sébastien Lopez; Isabelle Brabet; Ornella Valenti; Nadia Oueslati; Florence Gaven; Cyril Goudet; Hugues-Olivier BERTRAND; Jacques Neyton; Michael J Marino; Marianne Amalric; Jean-Philippe Pin; Francine Acher
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
Journal of medicinal chemistry 2007;50(15):3585-95.
2007: Gaël Barthet; Bérénice Framery; Florence Gaven; Lucie Pellissier; Eric Reiter; Sylvie Claeysen; Joël Bockaert; Aline Dumuis
5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.
Molecular biology of the cell 2007;18(6):1979-91.
2005: Gaël Barthet; Florence Gaven; Bérénice Framery; Katsuhiro Shinjo; Takaaki Nakamura; Sylvie Claeysen; Joël Bockaert; Aline Dumuis
Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.
The Journal of biological chemistry 2005;280(30):27924-34.
2005: Evgeni Ponimaskin; Aline Dumuis; Florence Gaven; Gaël Barthet; Martin Heine; Konstantin Glebov; Diethelm W Richter; Martin Oppermann
Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis.
Molecular pharmacology 2005;67(5):1434-43.
2004: Cyril Goudet; Florence Gaven; Julie Kniazeff; Claire Vol; Jiangfeng Liu; Martin Cohen-Gonsaud; Francine Acher; Laurent Prézeau; Jean-Philippe Pin
Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):378-83.
2003: Claude J Dechesne; Pierre G Milhaud; Danielle Demêmes; Stéphanie Ventéo; Florence Gaven; Jacqueline Raymond
Confinement but not microgravity alters NMDA NR1 receptor expression in rat inner ear ganglia.
Neuroreport 2003;14(6):887-90.
2002: Anne-Sophie Bessis; Philippe Rondard; Florence Gaven; Isabelle Brabet; Nicolas Triballeau; Laurent Prezeau; Francine Acher; Jean-Philippe Pin
Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11097-102.
2001: Danielle Demêmes; Claude J Dechesne; S Venteo; Florence Gaven; Jacqueline Raymond
Development of the rat efferent vestibular system on the ground and in microgravity.
Brain research. Developmental brain research 2001;128(1):35-44.