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Narender Gavva

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Nuria A Tamayo; Phi Tang; Weiya Wang; Brad Youngblood; Michael D Bartberger; Yunxin Bo; Jiyun Chen; Tiffany L Correll; Hong Deng; Narender R Gavva; Vijay K Gore; Lana Klionsky; Sonya G Lehto; Vu V Ma; Nobuko Nishimura; Mark H Norman
Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.
Maria C Almeida; Prafulla Aryal; Diana Bautista; Andras Garami; Narender R Gavva; Tamara Hew-Butler; Tatiane B Nucci; Daniela L Oliveira; Sara Rao; Renato N Soriano; Nuria Tamayo; Judy Wang; Weiya Wang; Andrej A Romanovsky
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.
Samuel Penna Wanner; Cândido C Coimbra; Andras Garami; Narender R Gavva; Daniela L Oliveira; Eszter Pakai; Andrej A Romanovsky
Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory.

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All Publications

2012: Nuria A Tamayo; Phi Tang; Weiya Wang; Brad Youngblood; Michael D Bartberger; Yunxin Bo; Jiyun Chen; Tiffany L Correll; Hong Deng; Narender R Gavva; Vijay K Gore; Lana Klionsky; Sonya G Lehto; Vu V Ma; Nobuko Nishimura; Mark H Norman
Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.
Journal of medicinal chemistry 2012;55(4):1593-611.
2012: Maria C Almeida; Prafulla Aryal; Diana Bautista; Andras Garami; Narender R Gavva; Tamara Hew-Butler; Tatiane B Nucci; Daniela L Oliveira; Sara Rao; Renato N Soriano; Nuria Tamayo; Judy Wang; Weiya Wang; Andrej A Romanovsky
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(6):2086-99.
2012: Samuel Penna Wanner; Cândido C Coimbra; Andras Garami; Narender R Gavva; Daniela L Oliveira; Eszter Pakai; Andrej A Romanovsky
Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory.
Cell cycle (Georgetown, Tex.) 2012;11(2):343-9.
2012: Narender R Gavva; Sonya G Lehto; Sara Rao; Weiya Wang; Carl Davis; Dawn X D Zhu
Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation.
Molecular pain 2012;8():36.
2011: Alexandre A Steiner; Alla Y Molchanova; M Devrim Dogan; Shreya Patel; Erika Pétervári; Márta Balaskó; Samuel Penna Wanner; Justin Eales; Daniela L Oliveira; Narender R Gavva; Maria C Almeida; Miklós Székely; Andrej A Romanovsky
The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.
The Journal of physiology 2011;589(Pt 9):2415-31.
2011: Andras Garami; Eszter Pakai; Daniela L Oliveira; Alexandre A Steiner; Samuel Penna Wanner; Maria C Almeida; Vladimir A Lesnikov; Narender R Gavva; Andrej A Romanovsky
Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(5):1721-33.
2010: Andras Garami; Yury P Shimansky; Eszter Pakai; Daniela L Oliveira; Narender R Gavva; Andrej A Romanovsky
Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(4):1435-40.
2009: Gilbert Y Wong; Narender R Gavva
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks.
Brain research reviews 2009;60(1):267-77.
2008: Narender R Gavva
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1.
Trends in pharmacological sciences 2008;29(11):550-7.
2008: Markian M Stec; Yunxin Bo; Partha P Chakrabarti; Lillian Liao; Mqhele Ncube; Nuria A Tamayo; Rami Tamir; Narender R Gavva; James J S Treanor; Mark H Norman
Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2008;18(18):5118-22.
2008: Sonya G Lehto; Rami Tamir; Hong Deng; Lana Klionsky; Rongzhen Kuang; April Le; Doo Lee; Jean-Claude Louis; Ella Magal; Barton H Manning; John Rubino; Sekhar Surapaneni; Nuria Tamayo; Tingrong Wang; Judy Wang; Jue Wang; Weiya Wang; Brad Youngblood; Maosheng Zhang; Dawn Zhu; Mark H Norman; Narender R Gavva
Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats.
The Journal of pharmacology and experimental therapeutics 2008;326(1):218-29.
2008: Chaoran Wu; Narender R Gavva; Timothy Brennan
Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision.
Anesthesiology 2008;108(6):1100-8.
2008: Nuria Tamayo; Hongyu Liao; Markian M Stec; Xianghong Wang; Partha Chakrabarti; Dan Retz; Elizabeth M Doherty; Sekhar Surapaneni; Rami Tamir; Anthony W Bannon; Narender R Gavva; Mark H Norman
Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists.
Journal of medicinal chemistry 2008;51(9):2744-57.
2008: Narender R Gavva; James J S Treanor; Andras Garami; Liang Fang; Sekhar Surapaneni; Anna Akrami; Francisco Alvarez; Annette Bak; Mary Darling; Anu Gore; Graham R Jang; James P Kesslak; Liyun Ni; Mark H Norman; Gabrielle Palluconi; Mark J Rose; Margaret Salfi; Edward Tan; Andrej A Romanovsky; Christopher Banfield; Gudarz Davar
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans.
Pain 2008;136(1-2):202-10.
2008: Elizabeth M Doherty; Daniel Retz; Narender R Gavva; Rami Tamir; James J S Treanor; Mark H Norman
4-Aminopyrimidine tetrahydronaphthols: a series of novel vanilloid receptor-1 antagonists with improved solubility properties.
Bioorganic & medicinal chemistry letters 2008;18(6):1830-4.
2008: Andreas Leffler; Michael J Fischer; Dietlinde Rehner; Stephanie Kienel; Katrin Kistner; Susanne K Sauer; Narender R Gavva; Peter W Reeh; Carla Nau
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons.
The Journal of clinical investigation 2008;118(2):763-76.
2007: Xianghong Wang; Partha P Chakrabarti; Vassil I Ognyanov; Liping H Pettus; Rami Tamir; Helming Tan; Phi Tang; James J S Treanor; Narender R Gavva; Mark H Norman
Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility.
Bioorganic & medicinal chemistry letters 2007;17(23):6539-45.
2007: Vijay K Gore; Vu V Ma; Rami Tamir; Narender R Gavva; James J S Treanor; Mark H Norman
Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2007;17(21):5825-30.
2007: Narender R Gavva; Anthony W Bannon; David N Hovland; Sonya G Lehto; Lana Klionsky; Sekhar Surapaneni; David C Immke; Charles Henley; Leyla Arik; Annette Bak; James Davis; Nadia Ernst; Gal Hever; Rongzhen Kuang; Licheng Shi; Rami Tamir; Jue Wang; Weiya Wang; Gary Zajic; Dawn Zhu; Mark H Norman; Jean-Claude Louis; Ella Magal; James J S Treanor
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade.
The Journal of pharmacology and experimental therapeutics 2007;323(1):128-37.
2007: Hui-Ling Wang; Jodie Katon; Chenera Balan; Anthony W Bannon; Charles Bernard; Elizabeth M Doherty; Celia Dominguez; Narender R Gavva; Vijay K Gore; Vu V Ma; Nobuko Nishimura; Sekhar Surapaneni; Phi Tang; Rami Tamir; Oliver Thiel; James J S Treanor; Mark H Norman
Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.
Journal of medicinal chemistry 2007;50(15):3528-39.
2007: Elizabeth M Doherty; Christopher Fotsch; Anthony W Bannon; Yunxin Bo; Ning Chen; Celia Dominguez; James Falsey; Narender R Gavva; Jodie Katon; Thomas Nixey; Vassil I Ognyanov; Liping Pettus; Robert M Rzasa; Markian Stec; Sekhar Surapaneni; Rami Tamir; Jiawang Zhu; James J S Treanor; Mark H Norman
Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate.
Journal of medicinal chemistry 2007;50(15):3515-27.
2007: Mark H Norman; Jiawang Zhu; Christopher Fotsch; Yunxin Bo; Ning Chen; Partha P Chakrabarti; Elizabeth M Doherty; Narender R Gavva; Nobuko Nishimura; Thomas Nixey; Vassil I Ognyanov; Robert M Rzasa; Markian Stec; Sekhar Surapaneni; Rami Tamir; Vellarkad Viswanadhan; James J S Treanor
Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.
Journal of medicinal chemistry 2007;50(15):3497-514.
2007: Alexandre A Steiner; Victoria F Turek; Maria C Almeida; Jeffrey J Burmeister; Daniela L Oliveira; Jennifer L Roberts; Anthony W Bannon; Mark H Norman; Jean-Claude Louis; James J S Treanor; Narender R Gavva; Andrej A Romanovsky
Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(28):7459-68.
2007: Narender R Gavva; Anthony W Bannon; Sekhar Surapaneni; David N Hovland; Sonya G Lehto; Anu Gore; Todd Juan; Hong Deng; Bora Han; Lana Klionsky; Rongzhen Kuang; April Le; Rami Tamir; Jue Wang; Brad Youngblood; Dawn Zhu; Mark H Norman; Ella Magal; James J S Treanor; Jean-Claude Louis
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(13):3366-74.
2007: Lana Klionsky; Rami Tamir; Baoxi Gao; Weiya Wang; David C Immke; Nobuko Nishimura; Narender R Gavva
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists.
Molecular pain 2007;3():39.
2006: David C Immke; Narender R Gavva
The TRPV1 receptor and nociception.
Seminars in cell & developmental biology 2006;17(5):582-91.
2006: Lana Klionsky; Rami Tamir; Bob Holzinger; Xiaojuan Bi; Jane Talvenheimo; Helen Kim; Frank Martin; Jean-Claude Louis; James J S Treanor; Narender R Gavva
A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation.
The Journal of pharmacology and experimental therapeutics 2006;319(1):192-8.
2006: Vassil I Ognyanov; Chenera Balan; Anthony W Bannon; Yunxin Bo; Celia Dominguez; Christopher Fotsch; Vijay K Gore; Lana Klionsky; Vu V Ma; Yi-Xin Qian; Rami Tamir; Xianghong Wang; Ning Xi; Shimin Xu; Dawn Zhu; Narender R Gavva; James J S Treanor; Mark H Norman
Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.
Journal of medicinal chemistry 2006;49(12):3719-42.
2005: Ning Xi; Yunxin Bo; Elizabeth M Doherty; Christopher Fotsch; Narender R Gavva; Nianhe Han; Randall W Hungate; Lana Klionsky; Qingyian Liu; Rami Tamir; Shimin Xu; James J S Treanor; Mark H Norman
Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists.
Bioorganic & medicinal chemistry letters 2005;15(23):5211-7.
2005: Narender R Gavva; Rami Tamir; Lana Klionsky; Mark H Norman; Jean-Claude Louis; Kenneth D Wild; James J S Treanor
Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1.
Molecular pharmacology 2005;68(6):1524-33.
2005: Narender R Gavva; Rami Tamir; Yusheng Qu; Lana Klionsky; Tie J Zhang; David C Immke; Judy Wang; Dawn Zhu; Todd W Vanderah; Frank Porreca; Elizabeth M Doherty; Mark H Norman; Kenneth D Wild; Anthony W Bannon; Jean-Claude Louis; James J S Treanor
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
The Journal of pharmacology and experimental therapeutics 2005;313(1):474-84.
2005: Elizabeth M Doherty; Christopher Fotsch; Yunxin Bo; Partha P Chakrabarti; Ning Chen; Narender R Gavva; Nianhe Han; Michael G Kelly; John Kincaid; Lana Klionsky; Qingyian Liu; Vassil I Ognyanov; Rami Tamir; Xianghong Wang; Jiawang Zhu; Mark H Norman; James J S Treanor
Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.
Journal of medicinal chemistry 2005;48(1):71-90.
2004: Narender R Gavva; Lana Klionsky; Yusheng Qu; Licheng Shi; Rami Tamir; Steve Edenson; Tie J Zhang; Vellarkad Viswanadhan; Attila Toth; Larry V Pearce; Todd W Vanderah; Frank Porreca; Peter M Blumberg; Jack Lile; Yax Sun; Kenneth D Wild; Jean-Claude Louis; James J S Treanor
Molecular determinants of vanilloid sensitivity in TRPV1.
The Journal of biological chemistry 2004;279(19):20283-95.
2002: Vemuganti L Raghavendra Rao; Kellie K Bowen; Vinay K Dhodda; Guoqing Song; James L Franklin; Narender R Gavva; Robert J Dempsey
Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia.
Journal of neurochemistry 2002;83(5):1072-86.
2002: Narender R Gavva; Shau-Ching Wen; Pratibha Daftari; Mariko Moniwa; Wen-Ming Yang; Lan-Ping Teresa Yang-Feng; Edward Seto; James Davie; C-K James Shen
NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor.
Genomics 2002;79(3):423-31.
2001: X Chen; S Wen; M N Fukuda; Narender R Gavva; D Hsu; T O Akama; T Yang-Feng; C-K James Shen
Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2.
Genomics 2001;73(2):238-41.
2000: Shau-Ching Wen; Karim Roder; K Y Hu; I Rombel; Narender R Gavva; Pratibha Daftari; Y Y Kuo; C Wang; C-K James Shen
Loading of DNA-binding factors to an erythroid enhancer.
Molecular and cellular biology 2000;20(6):1993-2003.
1999: Pratibha Daftari; Narender R Gavva; C-K James Shen
Distinction between AP1 and NF-E2 factor-binding at specific chromatin regions in mammalian cells.
Oncogene 1999;18(39):5482-6.
1998: Bau-Lin Huang; I R Fan-Chiang; Shau-Ching Wen; H C Koo; W Y Kao; Narender R Gavva; C-K James Shen
Derepression of human embryonic zeta-globin promoter by a locus-control region sequence.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14669-74.
1997: Narender R Gavva; R Gavva; KS Ermekova; Marius Sudol; C J Shen
Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II.
The Journal of biological chemistry 1997;272(39):24105-8.