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Renate Gay

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Michelle Trenkmann; Beat A Michel; Matthias Brock; Renate E Gay; Steffen GAY; Lars C Huber
Tumor necrosis factor α-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling.
Britta Maurer; Beat A Michel; Nicole Reich; Georg Schett; Renate E Gay; Steffen GAY; Astrid Juengel; Jörg Kriegsmann; Jörg H W Distler; Oliver Distler
Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis.
Mária Filková; Renate E Gay; Astrid Jüngel; Steffen GAY
MicroRNAs in rheumatoid arthritis: potential role in diagnosis and therapy.

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2013: Michelle Trenkmann; Beat A Michel; Matthias Brock; Renate E Gay; Steffen GAY; Lars C Huber
Tumor necrosis factor α-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling.
Arthritis and rheumatism 2013;65(4):916-27.
2012: Britta Maurer; Beat A Michel; Nicole Reich; Georg Schett; Renate E Gay; Steffen GAY; Astrid Juengel; Jörg Kriegsmann; Jörg H W Distler; Oliver Distler
Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis.
Annals of the rheumatic diseases 2012;71(8):1382-7.
2012: Mária Filková; Renate E Gay; Astrid Jüngel; Steffen GAY
MicroRNAs in rheumatoid arthritis: potential role in diagnosis and therapy.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2012;26(3):131-41.
2012: Emmanuel Karouzakis; Renate E Gay; Steffen GAY; Michel Neidhart
Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2012;64(6):1809-17.
2012: Fabienne Niederer; Caroline Ospelt; Joanna Stanczyk; Michelle Trenkmann; Michael Detmar; Renate E Gay; Steffen GAY; Astrid Jüngel; Emmanuel Karouzakis; Christoph Kolling; Michel Neidhart; Diego Kyburz
Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance.
Arthritis and rheumatism 2012;64(6):1771-9.
2012: Nina Kesel; Dorothee Köhler; Peter Lamprecht; Martin Laudien; Michel Neidhart; Udo Schumacher; Elena Csernok; Renate E Gay; Steffen Gay; Wolfgang L Gross; Lena Herich; Konstanze Holl-Ulrich; Astrid Jüngel; Sebastian Ullrich
Cartilage destruction in granulomatosis with polyangiitis (Wegener's granulomatosis) is mediated by human fibroblasts after transplantation into immunodeficient mice.
The American journal of pathology 2012;180(5):2144-55.
2012: Kazuhiro Yokota; Hiromichi Suzuki; Ursula Fearon; Renate E Gay; Steffen Gay; Hossein Hemmatazad; Christoph Kolling; Toshihide Mimura; Takashi Miyazaki; Caroline Ospelt
The pattern-recognition receptor nucleotide-binding oligomerization domain--containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2012;64(5):1329-37.
2011: Matthias Brock; Renate E Gay; Steffen GAY; Rudolf Speich; Michelle Trenkmann; Lars C Huber
MicroRNA-18a enhances the interleukin-6-mediated production of the acute-phase proteins fibrinogen and haptoglobin in human hepatocytes.
The Journal of biological chemistry 2011;286(46):40142-50.
2011: Fabienne Niederer; Caroline Ospelt; Fabia Brentano; Michael Detmar; Renate E Gay; Steffen GAY; Michael O Hottiger; Diego Kyburz
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
Annals of the rheumatic diseases 2011;70(10):1866-73.
2011: Michelle Trenkmann; Christoph Kolling; Beat A Michel; Rudolf Speich; Matthias Brock; Renate E Gay; Steffen GAY; Lars C Huber
Expression and function of EZH2 in synovial fibroblasts: epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis.
Annals of the rheumatic diseases 2011;70(8):1482-8.
2011: Emmanuel Karouzakis; Renate E Gay; Steffen GAY; Michel Neidhart
Epigenetic deregulation in rheumatoid arthritis.
Advances in experimental medicine and biology 2011;711():137-49.
2010: Michel Neidhart; Emmanuel Karouzakis; Gerald G Schumann; Renate E Gay; Steffen Gay
Trex-1 deficiency in rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2010;62(9):2673-9.
2010: Hanna Maciejewska-Rodrigues; Emmanuel Karouzakis; Simon Strietholt; Hossein Hemmatazad; Michel Neidhart; Caroline Ospelt; Renate E Gay; Beat A Michel; Thomas Pap; Steffen GAY; Astrid Jüngel
Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression.
Journal of autoimmunity 2010;35(1):15-22.
2010: Britta Maurer; Joanna Stanczyk; Astrid Jüngel; Alfiya Akhmetshina; Michelle Trenkmann; Matthias Brock; Otylia Kowal-Bielecka; Renate E Gay; Beat A Michel; Jörg H W Distler; Steffen GAY; Oliver Distler
MicroRNA-29, a key regulator of collagen expression in systemic sclerosis.
Arthritis and rheumatism 2010;62(6):1733-43.
2010: Caroline Ospelt; Joachim C Mertens; Astrid Jüngel; Fabia Brentano; Hanna Maciejewska-Rodriguez; Lars C Huber; Hossein Hemmatazad; Thomas Wüest; Alexander Knuth; Renate E Gay; Beat A Michel; Steffen GAY; Christoph Renner; Stefan Bauer
Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2010;62(5):1224-35.
2009: Britta Maurer; Nicole Busch; Astrid Jüngel; Margarita Pileckyte; Renate E Gay; Beat A Michel; Georg Schett; Steffen GAY; Jörg Distler; Oliver Distler
Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis.
Circulation 2009;120(23):2367-76.
2009: Mariola Kurowska-Stolarska; Jörg H W Distler; Astrid Jüngel; Weronika Rudnicka; Elena Neumann; Thomas Pap; Roland H Wenger; Beat A Michel; Ulf Müller-Ladner; Renate E Gay; Wlodzimierz Maslinski; Steffen GAY; Oliver Distler
Inhibitor of DNA binding/differentiation 2 induced by hypoxia promotes synovial fibroblast-dependent osteoclastogenesis.
Arthritis and rheumatism 2009;60(12):3663-75.
2009: Emmanuel Karouzakis; Renate E Gay; Beat A Michel; Steffen GAY; Michel Neidhart
DNA hypomethylation in rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2009;60(12):3613-22.
2009: Hanna Maciejewska Rodrigues; Astrid Jüngel; Renate E Gay; Steffen GAY
Innate immunity, epigenetics and autoimmunity in rheumatoid arthritis.
Molecular immunology 2009;47(1):12-8.
2009: Michel Neidhart; X Baraliakos; Christian A Seemayer; C Zelder; Renate E Gay; Beat A Michel; H Boehm; Steffen GAY; J Braun
Expression of cathepsin K and matrix metalloproteinase 1 indicate persistent osteodestructive activity in long-standing ankylosing spondylitis.
Annals of the rheumatic diseases 2009;68(8):1334-9.
2009: Ingmar Meinecke; Géza Pap; Heidi Mendoza; Steffen Drange; Stephan Ender; Simon Strietholt; Renate E Gay; Christine Seyfert; Barbara Ink; Steffen Gay; Thomas Pap; Marvin A Peters
Small ubiquitin-like modifier 1 [corrected] mediates the resistance of prosthesis-loosening fibroblast-like synoviocytes against Fas-induced apoptosis.
Arthritis and rheumatism 2009;60(7):2065-70.
2009: Matthias Brock; Michelle Trenkmann; Renate E Gay; Beat A Michel; Steffen GAY; Manuel Fischler; Silvia Ulrich; Rudolf Speich; Lars C Huber
Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway.
Circulation research 2009;104(10):1184-91.
2009: Emmanuel Karouzakis; Renate E Gay; Steffen GAY; Michel Neidhart
Epigenetic control in rheumatoid arthritis synovial fibroblasts.
Nature reviews. Rheumatology 2009;5(5):266-72.
2009: Hossein Hemmatazad; Hanna Maciejewska Rodrigues; Britta Maurer; Fabia Brentano; Margarita Pileckyte; Jörg H W Distler; Renate E Gay; Beat A Michel; Steffen GAY; Lars C Huber; Oliver Distler; Astrid Jüngel
Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis.
Arthritis and rheumatism 2009;60(5):1519-29.
2009: Caroline Ospelt; Fabia Brentano; Astrid Jüngel; Yvonne Rengel; Christoph Kolling; Beat A Michel; Renate E Gay; Steffen Gay
Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2009;60(2):355-63.
2008: Caroline Ospelt; Fabia Brentano; Yvonne Rengel; Joanna Stanczyk; Christoph Kolling; Paul P Tak; Renate E Gay; Steffen Gay; Diego Kyburz
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis.
Arthritis and rheumatism 2008;58(12):3684-92.
2008: Serena Guiducci; Jörg H W Distler; Astrid Jüngel; Doerte Huscher; Lars C Huber; Beat A Michel; Renate E Gay; David S Pisetsky; Steffen Gay; Marco Matucci-Cerinic; Oliver Distler
The relationship between plasma microparticles and disease manifestations in patients with systemic sclerosis.
Arthritis and rheumatism 2008;58(9):2845-53.
2008: Philipp Drees; Anke Eckardt; Renate E Gay; Steffen GAY; Lars C Huber
[Molecular pathways in aseptic loosening of orthopaedic endoprosthesis].
Biomedizinische Technik. Biomedical engineering 2008;53(3):93-103.
2008: Joanna Stanczyk; Deena M Leslie Pedrioli; Fabia Brentano; Olga Sanchez-Pernaute; Christoph Kolling; Renate E Gay; Michael Detmar; Steffen Gay; Diego Kyburz
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis.
Arthritis and rheumatism 2008;58(4):1001-9.
2008: Caroline Ospelt; Mariola Kurowska-Stolarska; Michel Neidhart; Beat A Michel; Renate E Gay; Stefan Laufer; Steffen Gay
The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands.
Annals of the rheumatic diseases 2008;67(4):524-9.
2008: Lars C Huber; P Künzler; S H Boyce; Beat A Michel; Renate E Gay; B S Ink; Steffen Gay
Effects of a novel tyrosine kinase inhibitor in rheumatoid arthritis synovial fibroblasts.
Annals of the rheumatic diseases 2008;67(3):389-94.
2008: Natasa Reisch; Andrea Engler; André Aeschlimann; Beat R Simmen; Beat A Michel; Renate E Gay; Steffen Gay; Haiko Sprott
DREAM is reduced in synovial fibroblasts of patients with chronic arthritic pain: is it a suitable target for peripheral pain management?
Arthritis research & therapy 2008;10(3):R60.
2007: Jörg H W Distler; Astrid Jüngel; Margarita Pileckyte; Jochen Zwerina; Beat A Michel; Renate E Gay; Otylia Kowal-Bielecka; Marco Matucci-Cerinic; Georg Schett; Hugo H Marti; Steffen Gay; Oliver Distler
Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis.
Arthritis and rheumatism 2007;56(12):4203-15.
2007: Fabia Brentano; Olivier Schorr; Caroline Ospelt; Joanna Stanczyk; Renate E Gay; Steffen Gay; Diego Kyburz
Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities.
Arthritis and rheumatism 2007;56(9):2829-39.
2007: Andrea Engler; André Aeschlimann; Beat R Simmen; Beat A Michel; Renate E Gay; Steffen Gay; Haiko Sprott
Expression of transient receptor potential vanilloid 1 (TRPV1) in synovial fibroblasts from patients with osteoarthritis and rheumatoid arthritis.
Biochemical and biophysical research communications 2007;359(4):884-8.
2007: Lars C Huber; Jörg H W Distler; Falk Moritz; Hossein Hemmatazad; Thomas Hauser; Beat A Michel; Renate E Gay; Marco Matucci-Cerinic; Steffen Gay; Oliver Distler; Astrid Jüngel
Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis.
Arthritis and rheumatism 2007;56(8):2755-64.
2007: Souzan Salemi; André Aeschlimann; Uwe Wollina; Renate E Gay; Beat A Michel; Steffen Gay; Haiko Sprott
Up-regulation of delta-opioid receptors and kappa-opioid receptors in the skin of fibromyalgia patients.
Arthritis and rheumatism 2007;56(7):2464-6.
2007: Matthias Pierer; Fabia Brentano; Janine Rethage; Ulf Wagner; Holm Häntzschel; Renate E Gay; Steffen Gay; Diego Kyburz
The TNF superfamily member LIGHT contributes to survival and activation of synovial fibroblasts in rheumatoid arthritis.
Rheumatology (Oxford, England) 2007;46(7):1063-70.
2007: Lars C Huber; Matthias Brock; Hossein Hemmatazad; Olivier T Giger; Falk Moritz; Michelle Trenkmann; Jörg H W Distler; Renate E Gay; Christoph Kolling; Holger Moch; Beat A Michel; Steffen Gay; Oliver Distler; Astrid Jüngel
Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients.
Arthritis and rheumatism 2007;56(4):1087-93.
2007: Ingmar Meinecke; Antje Cinski; Anja Baier; Marvin A Peters; Berno Dankbar; Aline Wille; Andreas Drynda; Heidi Mendoza; Renate E Gay; Ron Thomas Hay; Barbara Ink; Steffen Gay; Thomas Pap
Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5073-8.
2007: Philipp Drees; Anke Eckardt; Renate E Gay; Steffen GAY; Lars C Huber
Mechanisms of disease: Molecular insights into aseptic loosening of orthopedic implants.
Nature clinical practice. Rheumatology 2007;3(3):165-71.
2007: Lars C Huber; Astrid Jüngel; Jörg H W Distler; Falk Moritz; Renate E Gay; Beat A Michel; David S Pisetsky; Steffen Gay; Oliver Distler
The role of membrane lipids in the induction of macrophage apoptosis by microparticles.
Apoptosis : an international journal on programmed cell death 2007;12(2):363-74.
2007: Stefan Kuchen; Christian A Seemayer; Michel Neidhart; Renate E Gay; Steffen Gay
In situ hybridization of synovial tissue.
Methods in molecular medicine 2007;135():65-75.
2007: Jörg H W Distler; Astrid Jüngel; Lars C Huber; Ursula Schulze-Horsel; Jochen Zwerina; Renate E Gay; Beat A Michel; Thomas Hauser; Georg Schett; Steffen Gay; Oliver Distler
Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis.
Arthritis and rheumatism 2007;56(1):311-22.
2006: Ladislav Senolt; Mariam Grigorian; Eugene Lukanidin; Beat R Simmen; Beat A Michel; Karel Pavelka; Renate E Gay; Steffen Gay; Michel Neidhart
S100A4 is expressed at site of invasion in rheumatoid arthritis synovium and modulates production of matrix metalloproteinases.
Annals of the rheumatic diseases 2006;65(12):1645-8.
2006: Haiko Sprott; Renate E Gay; Beat A Michel; Steffen Gay
Influence of ibuprofen-arginine on serum levels of nitric oxide metabolites in patients with chronic low back pain--a single-blind, placebo controlled pilot trial (ISRCTN18723747).
The Journal of rheumatology 2006;33(12):2515-8.
2006: Emmanuel Karouzakis; Michel Neidhart; Renate E Gay; Steffen Gay
Molecular and cellular basis of rheumatoid joint destruction.
Immunology letters 2006;106(1):8-13.
2006: Falk Moritz; Oliver Distler; Renate E Gay; Steffen Gay
[Molecular and cellular basis of joint destruction in rheumatoid arthritis].
Deutsche medizinische Wochenschrift (1946) 2006;131(27):1546-51.
2006: Astrid Jüngel; V Baresova; Caroline Ospelt; Beat R Simmen; Beat A Michel; Renate E Gay; Steffen Gay; Christian A Seemayer; Michel Neidhart
Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis.
Annals of the rheumatic diseases 2006;65(7):910-2.
2006: Lars C Huber; Oliver Distler; Ingo H Tarner; Renate E Gay; Steffen Gay; Thomas Pap
Synovial fibroblasts: key players in rheumatoid arthritis.
Rheumatology (Oxford, England) 2006;45(6):669-75.
2006: H Shen; Haiko Sprott; André Aeschlimann; Renate E Gay; Beat A Michel; Steffen Gay; H Sprott
Analgesic action of acetaminophen in symptomatic osteoarthritis of the knee.
Rheumatology (Oxford, England) 2006;45(6):765-70.
2006: Lars C Huber; Oliver Distler; Renate E Gay; Steffen Gay
Antisense strategies in degenerative joint diseases: sense or nonsense?
Advanced drug delivery reviews 2006;58(2):285-99.
2006: Joanna Stanczyk; Caroline Ospelt; Renate E Gay; Steffen Gay
Synovial cell activation.
Current opinion in rheumatology 2006;18(3):262-7.
2006: Falk Moritz; Oliver Distler; Caroline Ospelt; Renate E Gay; Steffen Gay
Technology insight: gene transfer and the design of novel treatments for rheumatoid arthritis.
Nature clinical practice. Rheumatology 2006;2(3):153-62.
2006: Atsushi Hashimoto; Ingo H Tarner; Renate E Gay; Ulf Müller-Ladner; Steffen Gay; Elena Neumann
High-resolution molecular analysis for research in rheumatology.
Current rheumatology reports 2006;8(1):1-2.
2006: Ladislav Senolt; Mariam Grigorian; Eugene Lukanidin; Beat A Michel; Renate E Gay; Steffen Gay; Karel Pavelka; Michel Neidhart
S100A4 (Mts1): is there any relation to the pathogenesis of rheumatoid arthritis?
Autoimmunity reviews 2006;5(2):129-31.
2006: Jörg H W Distler; Astrid Jüngel; David Caretto; Ursula Schulze-Horsel; Otylia Kowal-Bielecka; Renate E Gay; Beat A Michel; Ulf Müller-Ladner; Joachim R Kalden; Steffen Gay; Oliver Distler
Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells.
Arthritis and rheumatism 2006;54(1):214-25.
2005: Souzan Salemi; André Aeschlimann; Natasa Reisch; Astrid Jüngel; Renate E Gay; Frank L Heppner; Beat A Michel; Steffen Gay; Haiko Sprott
Detection of kappa and delta opioid receptors in skin--outside the nervous system.
Biochemical and biophysical research communications 2005;338(2):1012-7.
2005: Ulf Müller-Ladner; Thomas Pap; Renate E Gay; Michel Neidhart; Steffen GAY
Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis.
Nature clinical practice. Rheumatology 2005;1(2):102-10.
2005: Otylia Kowal-Bielecka; Krzysztof Kowal; Oliver Distler; Joanna Rojewska; Anna Bodzenta-Lukaszyk; Beat A Michel; Renate E Gay; Steffen GAY; Stanislaw Sierakowski
Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: an imbalance between proinflammatory and antiinflammatory lipid mediators.
Arthritis and rheumatism 2005;52(12):3783-91.
2005: Michel Neidhart; Astrid Jüngel; Caroline Ospelt; Beat A Michel; Renate E Gay; Steffen Gay
Deficient expression of interleukin-10 receptor alpha chain in rheumatoid arthritis synovium: limitation of animal models of inflammation.
Arthritis and rheumatism 2005;52(10):3315-8.
2005: Fabia Brentano; Olivier Schorr; Renate E Gay; Steffen Gay; Diego Kyburz
RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3.
Arthritis and rheumatism 2005;52(9):2656-65.
2005: Caroline Ospelt; Michel Neidhart; Renate E Gay; Steffen Gay
Gene analysis for exploring the effects of drugs in rheumatoid arthritis.
Arthritis and rheumatism 2005;52(8):2248-56.
2005: Edita Rutkauskaite; Dagmar Volkmer; Yukio Shigeyama; Jörg Schedel; Géza Pap; Ulf Müller-Ladner; Ingmar Meinecke; Dorothea Alexander; Renate E Gay; Susanne Drynda; Wolfram Neumann; Beat A Michel; Wilhelm K Aicher; Steffen Gay; Thomas Pap
Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2005;52(7):2010-4.
2005: Hua Shen; André Aeschlimann; Natasa Reisch; Renate E Gay; Beat R Simmen; Beat A Michel; Steffen Gay; Haiko Sprott
Kappa and delta opioid receptors are expressed but down-regulated in fibroblast-like synoviocytes of patients with rheumatoid arthritis and osteoarthritis.
Arthritis and rheumatism 2005;52(5):1402-10.
2005: Jörg H W Distler; Astrid Jüngel; Mariola Kurowska-Stolarska; Beat A Michel; Renate E Gay; Steffen Gay; Oliver Distler
Nucleofection: a new, highly efficient transfection method for primary human keratinocytes*.
Experimental dermatology 2005;14(4):315-20.
2005: Jörg H W Distler; Astrid Jüngel; Otylia Kowal-Bielecka; Beat A Michel; Renate E Gay; Haiko Sprott; Marco Matucci-Cerinic; Meike Chilla; Kristian Reich; Joachim R Kalden; Ulf Müller-Ladner; Hanns M Lorenz; Steffen Gay; Oliver Distler
Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis.
Arthritis and rheumatism 2005;52(3):856-64.
2005: Michel Neidhart; F Zaucke; R von Knoch; Astrid Jüngel; Beat A Michel; Renate E Gay; Steffen Gay
Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.
Annals of the rheumatic diseases 2005;64(3):419-24.
2005: Jörg H W Distler; Astrid Jüngel; Lars C Huber; Christian A Seemayer; Charles F Reich; Renate E Gay; Beat A Michel; Adriano Fontana; Steffen Gay; David S Pisetsky; Oliver Distler
The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2892-7.
2005: Fabia Brentano; Diego Kyburz; Olivier Schorr; Renate E Gay; Steffen Gay
The role of Toll-like receptor signalling in the pathogenesis of arthritis.
Cellular immunology 2005;233(2):90-6.
2005: Frank Hermann; Adrian Forster; Rémy Chenevard; Frank Enseleit; David Hürlimann; Roberto Corti; Lukas E Spieker; Diana Frey; Matthias Hermann; Walter Riesen; Michel Neidhart; Beat A Michel; Jens P Hellermann; Renate E Gay; Thomas F Lüscher; Steffen Gay; Georg Noll; Frank Ruschitzka
Simvastatin improves endothelial function in patients with rheumatoid arthritis.
Journal of the American College of Cardiology 2005;45(3):461-4.
2005: Ingo H Tarner; Peter Härle; Ulf Müller-Ladner; Renate E Gay; Steffen Gay
The different stages of synovitis: acute vs chronic, early vs late and non-erosive vs erosive.
Best practice & research. Clinical rheumatology 2005;19(1):19-35.
2004: Caroline Ospelt; Diego Kyburz; Matthias Pierer; Reinhart Seibl; M Kurowska; Oliver Distler; Michel Neidhart; U Muller-Ladner; Thomas Pap; Renate E Gay; Steffen Gay
Toll-like receptors in rheumatoid arthritis joint destruction mediated by two distinct pathways.
Annals of the rheumatic diseases 2004;63 Suppl 2():ii90-ii91.
2004: Jörg Schedel; Oliver Distler; Matthias Woenckhaus; Renate E Gay; Beat R Simmen; Beat A Michel; Ulf Müller-Ladner; Steffen Gay
Discrepancy between mRNA and protein expression of tumour suppressor maspin in synovial tissue may contribute to synovial hyperplasia in rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(10):1205-11.
2004: Lars C Huber; Thomas Pap; Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Gene targeting: roadmap to future therapies.
Current rheumatology reports 2004;6(5):323-5.
2004: Amelie M Lutz; Christian A Seemayer; claire corot; Renate E Gay; Kerstin Goepfert; Beat A Michel; Borut Marincek; Steffen Gay; Dominik Weishaupt
Detection of synovial macrophages in an experimental rabbit model of antigen-induced arthritis: ultrasmall superparamagnetic iron oxide-enhanced MR imaging.
Radiology 2004;233(1):149-57.
2004: Thomas Pap; Michael Nawrath; Jochen Heinrich; Magnus Bosse; Anja Baier; Klaus M Hummel; Peter Petrow; Stefan Kuchen; Beat A Michel; Renate E Gay; Ulf Müller-Ladner; Karin Moelling; Steffen Gay
Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis.
Arthritis and rheumatism 2004;50(9):2794-802.
2004: Caroline Ospelt; Michel Neidhart; Renate E Gay; Steffen Gay
Synovial activation in rheumatoid arthritis.
Frontiers in bioscience : a journal and virtual library 2004;9():2323-34.
2004: Oliver Distler; Jörg H W Distler; Annette Scheid; Till Acker; Astrid Hirth; Janine Rethage; Beat A Michel; Renate E Gay; Ulf Müller-Ladner; Marco Matucci-Cerinic; Karl H Plate; Max Gassmann; Steffen Gay
Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis.
Circulation research 2004;95(1):109-16.
2004: J T Studýnková; Stefan Kuchen; E Jeisy; Jörg Schedel; F Charvát; K Jarosová; H Sprott; M Matucci-Cerinic; Renate E Gay; Beat A Michel; Karel Pavelka; J Vencovský; Steffen Gay
The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis.
Clinical and experimental rheumatology 2004;22(4):395-402.
2004: Jörg Schedel; Christian A Seemayer; Thomas Pap; Michel Neidhart; Stefan Kuchen; Beat A Michel; Renate E Gay; Ulf Müller-Ladner; Steffen Gay; W Zacharias
Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.
Gene therapy 2004;11(13):1040-7.
2004: Astrid Jüngel; Jörg H W Distler; Mariola Kurowska-Stolarska; Christian A Seemayer; Reinhart Seibl; Adrian Forster; Beat A Michel; Renate E Gay; Frank Emmrich; Steffen Gay; Oliver Distler
Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis.
Arthritis and rheumatism 2004;50(5):1468-76.
2004: Edita Rutkauskaite; Wolfgang Zacharias; Jörg Schedel; Ulf Müller-Ladner; Christian Mawrin; Christian A Seemayer; Dorothea Alexander; Renate E Gay; Wilhelm K Aicher; Beat A Michel; Steffen Gay; Thomas Pap
Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2004;50(5):1448-56.
2004: Elena Neumann; Renate E Gay; Steffen Gay; Ulf Müller-Ladner
Functional genomics of fibroblasts.
Current opinion in rheumatology 2004;16(3):238-45.
2004: Haiko Sprott; Souzan Salemi; Renate E Gay; LA Bradley; G S Alarcón; S J Oh; Beat A Michel; Steffen Gay
Increased DNA fragmentation and ultrastructural changes in fibromyalgic muscle fibres.
Annals of the rheumatic diseases 2004;63(3):245-51.
2004: Stefan Kuchen; Christian A Seemayer; Janine Rethage; Rebecca von Knoch; Peter Kuenzler; A Michel Beat; Renate E Gay; Steffen Gay; Michel Neidhart
The L1 retroelement-related p40 protein induces p38delta MAP kinase.
Autoimmunity 2004;37(1):57-65.
2004: Jörg H W Distler; Claudia Hagen; Astrid Hirth; Ulf Müller-Ladner; Hanns M Lorenz; Angela Del Rosso; Beat A Michel; Renate E Gay; Ratanavadee Nanagara; Kusuki Nishioka; Marco Matucci-Cerinic; Joachim R Kalden; Steffen Gay; Oliver Distler
Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways.
Molecular pharmacology 2004;65(2):389-99.
2004: Matthias Pierer; Janine Rethage; Reinhart Seibl; Roger Lauener; Fabia Brentano; Ulf Wagner; Holm Häntzschel; Beat A Michel; Renate E Gay; Steffen Gay; Diego Kyburz
Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1256-65.
2003: Christian A Seemayer; Stefan Kuchen; Michel Neidhart; Peter Kuenzler; Veronika Rihosková; E Neumann; Martin Pruschy; Wilhelm K Aicher; Ulf Müller-Ladner; Renate E Gay; Beat A Michel; Gary S Firestein; Steffen Gay
p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion.
Annals of the rheumatic diseases 2003;62(12):1139-44.
2003: Matthias Hermann; Giovanni G Camici; Aisha Fratton; David Hurlimann; Felix C Tanner; Jens P Hellermann; Georg Martin Fiedler; Joachim Thiery; Michel Neidhart; Renate E Gay; Steffen Gay; Thomas F Lüscher; Frank Ruschitzka
Differential effects of selective cyclooxygenase-2 inhibitors on endothelial function in salt-induced hypertension.
Circulation 2003;108(19):2308-11.
2003: Souzan Salemi; André Aeschlimann; Renate E Gay; Beat A Michel; Steffen Gay; Lorenzo Kaeser; Haiko Sprott
Expression and localization of opioid receptors in muscle satellite cells: no difference between fibromyalgia patients and healthy subjects.
Arthritis and rheumatism 2003;48(11):3291-3.
2003: Shiro Ohshima; Stefan Kuchen; Christian A Seemayer; Diego Kyburz; Astrid Hirt; Stephanie Klinzing; Beat A Michel; Renate E Gay; Fu-Tong Liu; Steffen Gay; Michel Neidhart
Galectin 3 and its binding protein in rheumatoid arthritis.
Arthritis and rheumatism 2003;48(10):2788-95.
2003: Jörg H W Distler; Astrid Hirth; Mariola Kurowska-Stolarska; Renate E Gay; Steffen Gay; Oliver Distler
Angiogenic and angiostatic factors in the molecular control of angiogenesis.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 2003;47(3):149-61.
2003: Zsuzsanna Ortutay; Anna Polgár; Béla Gömör; Pál Géher; Tamás Lakatos; Tibor T Glant; Renate E Gay; Steffen GAY; Eva Pállinger; Csaba Farkas; Eva Farkas; László Tóthfalusi; Katalin Kocsis; András Falus; Edit Buzás
Synovial fluid exoglycosidases are predictors of rheumatoid arthritis and are effective in cartilage glycosaminoglycan depletion.
Arthritis and rheumatism 2003;48(8):2163-72.
2003: Matthias Pierer; Ulf Müller-Ladner; Thomas Pap; Michel Neidhart; Renate E Gay; Steffen Gay
The SCID mouse model: novel therapeutic targets - lessons from gene transfer.
Springer seminars in immunopathology 2003;25(1):65-78.
2003: Peter Kuenzler; Stefan Kuchen; Veronika Rihosková; Beat A Michel; Renate E Gay; Michel Neidhart; Steffen Gay; Christian A Seemayer
Induction of p16 at sites of cartilage invasion in the SCID mouse coimplantation model of rheumatoid arthritis.
Arthritis and rheumatism 2003;48(7):2069-73.
2003: Michel Neidhart; Christian A Seemayer; Klaus M Hummel; Beat A Michel; Renate E Gay; Steffen Gay
Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: destructive potential in vitro and in vivo.
Arthritis and rheumatism 2003;48(7):1873-80.
2003: Ulf Müller-Ladner; Thomas Pap; Renate E Gay; Steffen Gay
Gene transfer as a future therapy for rheumatoid arthritis.
Expert opinion on biological therapy 2003;3(4):587-98.
2003: Otylia Kowal-Bielecka; Oliver Distler; Krzysztof Kowal; Zenon Siergiejko; Justyna Chwiećko; Artur Sulik; Renate E Gay; Anna Bodzenta Łukaszyk; Steffen Gay; Stanislaw Sierakowski
Elevated levels of leukotriene B4 and leukotriene E4 in bronchoalveolar lavage fluid from patients with scleroderma lung disease.
Arthritis and rheumatism 2003;48(6):1639-46.
2003: Christian A Seemayer; Stefan Kuchen; Peter Kuenzler; Veronika Rihosková; Janine Rethage; Wilhelm K Aicher; Beat A Michel; Renate E Gay; Diego Kyburz; Michel Neidhart; Steffen Gay
Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis.
The American journal of pathology 2003;162(5):1549-57.
2003: Reinhart Seibl; Thomas Birchler; Susanne Loeliger; Johann Peter Hossle; Renate E Gay; Traudl Saurenmann; Beat A Michel; Reinhard Seger; Steffen Gay; Roger Lauener
Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium.
The American journal of pathology 2003;162(4):1221-7.
2003: Insa Hilbers; Torsten Hansen; Peter Petrow; Andreas Gaumann; Rolf Bräuer; Günther Salzmann; Renate E Gay; Hartwig Kosmehl; Charles James Kirkpatrick; Steffen Gay; Jörg Kriegsmann
Expression of the apoptosis accelerator Bax in rheumatoid arthritis synovium.
Rheumatology international 2003;23(2):75-81.
2003: Diego Kyburz; Janine Rethage; Reinhart Seibl; Roger Lauener; Renate E Gay; Dennis A Carson; Steffen Gay
Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling.
Arthritis and rheumatism 2003;48(3):642-50.
2003: Willemijn H van der Laan; Paul H A Quax; Christian A Seemayer; L G M Huisman; Elsbet Pieterman; Jos M Grimbergen; Jan H Verheijen; Ferdinand C Breedveld; Renate E Gay; Steffen Gay; Tom W J Huizinga; Thomas Pap
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3.
Gene therapy 2003;10(3):234-42.
2003: Rémy Chenevard; David Hürlimann; Markus Béchir; Frank Enseleit; Lukas E Spieker; Matthias Hermann; Walter Riesen; Steffen Gay; Renate E Gay; Michel Neidhart; Beat Michel; Thomas F Lüscher; Georg Noll; Frank Ruschitzka
Selective COX-2 inhibition improves endothelial function in coronary artery disease.
Circulation 2003;107(3):405-9.
2003: Thomas Pap; Anja Claus; Susumu Ohtsu; Klaus M Hummel; Peter Schwartz; Susanne Drynda; Géza Pap; Andreas Machner; Bernhard Stein; Michael George; Renate E Gay; Wolfram Neumann; Steffen Gay; Wilhelm K Aicher
Osteoclast-independent bone resorption by fibroblast-like cells.
Arthritis research & therapy 2003;5(3):R163-73.
2003: Souzan Salemi; Janine Rethage; Uwe Wollina; Beat A Michel; Renate E Gay; Steffen Gay; Haiko Sprott
Detection of interleukin 1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia.
The Journal of rheumatology 2003;30(1):146-50.
2002: Elena Neumann; Martin Judex; Frank Kullmann; Joachim Grifka; P D Robbins; T Pap; Renate E Gay; C H Evans; Steffen Gay; Jurgen Schölmerich; Ulf Müller-Ladner
Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway.
Gene therapy 2002;9(22):1508-19.
2002: Steffen Gay; Stefan Kuchen; Renate E Gay; Michel Neidhart
Cartilage destruction in rheumatoid arthritis.
Annals of the rheumatic diseases 2002;61 Suppl 2():ii87.
2002: David Hürlimann; Adrian Forster; Georg Noll; Frank Enseleit; Rémy Chenevard; Oliver Distler; Markus Béchir; Lukas E Spieker; Michel Neidhart; Beat A Michel; Renate E Gay; Thomas F Lüscher; Steffen Gay; Frank Ruschitzka
Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis.
Circulation 2002;106(17):2184-7.
2002: Christian A Seemayer; Stefan A Kolb; Michel Neidhart; Shiro Ohshima; Renate E Gay; Beat A Michel; Steffen Gay; Jürg Böni; Jörg Schüpbach
Absence of inducible retroviruses from synovial fibroblasts and synovial fluid cells of patients with rheumatoid arthritis.
Arthritis and rheumatism 2002;46(10):2811-3.
2002: Jörg Schedel; Renate E Gay; Peter Kuenzler; Christian A Seemayer; Beat R Simmen; Beat A Michel; Steffen Gay
FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis.
Arthritis and rheumatism 2002;46(6):1512-8.
2002: Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Role of nuclear factor kappaB in synovial inflammation.
Current rheumatology reports 2002;4(3):201-7.
2002: Peter Petrow; Dirk Wernicke; C Schulze Westhoff; Klaus M Hummel; Rolf Bräuer; Jörg Kriegsmann; Erika Gromnica-Ihle; Renate E Gay; Steffen Gay
Characterisation of the cell type-specificity of collagenase 3 mRNA expression in comparison with membrane type 1 matrix metalloproteinase and gelatinase A in the synovial membrane in rheumatoid arthritis.
Annals of the rheumatic diseases 2002;61(5):391-7.
2002: Oliver Distler; Angela Del Rosso; Roberto Giacomelli; Paola Cipriani; Maria Letizia Conforti; Serena Guiducci; Renate E Gay; Beat A Michel; Pius Brühlmann; Ulf Müller-Ladner; Steffen Gay; Marco Matucci-Cerinic
Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers.
Arthritis research 2002;4(6):R11.
2002: Kimio Masuda; Riako Masuda; Michel Neidhart; Beat R Simmen; Beat A Michel; Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation.
Arthritis research 2002;4(5):R8.
2002: Oliver Distler; Michel Neidhart; Renate E Gay; Steffen Gay
The molecular control of angiogenesis.
International reviews of immunology 2002;21(1):33-49.
2002: Thomas Pap; Renate E Gay; Ulf Müller-Ladner; Steffen Gay
Ex vivo gene transfer in the years to come.
Arthritis research 2002;4(1):10-2.
2001: Oliver Distler; Thomas Pap; Otylia Kowal-Bielecka; Rotraud Meyringer; Serena Guiducci; M Landthaler; Jürgen Schölmerich; Beat A Michel; Renate E Gay; Marco Matucci-Cerinic; Steffen Gay; Ulf Müller-Ladner
Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis.
Arthritis and rheumatism 2001;44(11):2665-78.
2001: Christian A Seemayer; Oliver Distler; Stefan Kuchen; Ulf Müller-Ladner; Beat A Michel; Michel Neidhart; Renate E Gay; Steffen Gay
[Rheumatoid arthritis: new developments in the pathogenesis with special reference to synovial fibroblasts].
Zeitschrift für Rheumatologie 2001;60(5):309-18.
2001: Renate E Gay; Michel Neidhart; F Pataky; Susanne Tries; Stefan Laufer; Steffen Gay
Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.
The Journal of rheumatology 2001;28(9):2060-5.
2001: Otylia Kowal-Bielecka; Oliver Distler; Michel Neidhart; P Künzler; Janine Rethage; Michael Nawrath; A Carossino; Thomas Pap; Ulf Müller-Ladner; Beat A Michel; Stanislaw Sierakowski; Marco Matucci-Cerinic; Renate E Gay; Steffen Gay
Evidence of 5-lipoxygenase overexpression in the skin of patients with systemic sclerosis: a newly identified pathway to skin inflammation in systemic sclerosis.
Arthritis and rheumatism 2001;44(8):1865-75.
2001: Gaye Cunnane; Oliver FitzGerald; Klaus M Hummel; Peter P Youssef; Renate E Gay; Steffen Gay; Barry Bresnihan
Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis.
Arthritis and rheumatism 2001;44(8):1744-53.
2001: Christian A Seemayer; Sergei Viazov; Michel Neidhart; Pius Brühlmann; Beat A Michel; Renate E Gay; Michael Roggendorf; Steffen Gay
Prevalence of TTV DNA and GBV-C RNA in patients with systemic sclerosis, rheumatoid arthritis, and osteoarthritis does not differ from that in healthy blood donors.
Annals of the rheumatic diseases 2001;60(8):806-9.
2001: Sarah L Morgan; Joseph E Baggott; Wanda Bernreuter; Renate E Gay; Ramin B Arani; Graciela S Alarcón
MTX affects inflammation and tissue destruction differently in the rat AA model.
The Journal of rheumatology 2001;28(7):1476-81.
2001: Géza Pap; Andreas Machner; T Rinnert; D Hörler; Renate E Gay; Helmut Schwarzberg; Wolfram Neumann; Beat A Michel; Steffen Gay; Thomas Pap
Development and characteristics of a synovial-like interface membrane around cemented tibial hemiarthroplasties in a novel rat model of aseptic prosthesis loosening.
Arthritis and rheumatism 2001;44(4):956-63.
2001: Thomas Pap; KR Aupperle; Steffen Gay; Gary S Firestein; Renate E Gay
Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion.
Arthritis and rheumatism 2001;44(3):676-81.
2001: Oliver Distler; Christian A Seemayer; Thomas Pap; Renate E Gay; Michel Neidhart; Ulf Müller-Ladner; Steffen Gay
Gene transfer of protective cytokines in rheumatoid arthritis.
Advances in experimental medicine and biology 2001;495():231-40.
2000: Michel Neidhart; Janine Rethage; Stefan Kuchen; P Künzler; R M Crowl; Michael E J Billingham; Renate E Gay; Steffen Gay
Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression.
Arthritis and rheumatism 2000;43(12):2634-47.
2000: Thomas Pap; Willemijn H van der Laan; KR Aupperle; Renate E Gay; Jan H Verheijen; Gary S Firestein; Steffen Gay; Michel Neidhart
Modulation of fibroblast-mediated cartilage degradation by articular chondrocytes in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(11):2531-6.
2000: Yukio Shigeyama; Thomas Pap; P Kunzler; B R Simmen; Renate E Gay; Steffen Gay
Expression of osteoclast differentiation factor in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(11):2523-30.
2000: Haiko Sprott; Thomas Pap; Janine Rethage; W Wintersberger; Renate E Gay; LA Bradley; Daniel Uebelhart; Steffen Gay
Expression of the precursor of secretoneurin, secretogranin II, in the synovium of patients with rheumatoid arthritis and osteoarthritis.
The Journal of rheumatology 2000;27(10):2347-50.
2000: Stefan Kuchen; T Pap; Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Gene transfer in rheumatoid arthritis: a novel therapeutic approach.
Clinical and experimental rheumatology 2000;18(5):543-5.
2000: C Hilty; Pius Brühlmann; H Sprott; Renate E Gay; Beat A Michel; Steffen Gay; Michel Neidhart
Altered diurnal rhythm of prolactin in systemic sclerosis.
The Journal of rheumatology 2000;27(9):2160-5.
2000: Michel Neidhart; Renate E Gay; Steffen Gay
Anti-interleukin-1 and anti-CD44 interventions producing significant inhibition of cartilage destruction in an in vitro model of cartilage invasion by rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2000;43(8):1719-28.
2000: Willemijn H van der Laan; Thomas Pap; H Karel Ronday; Jos M Grimbergen; L G M Huisman; Johan teKoppele; Ferdinand C Breedveld; Renate E Gay; Steffen Gay; Tom W J Huizinga; Jan H Verheijen; Paul H A Quax
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor.
Arthritis and rheumatism 2000;43(8):1710-8.
2000: Peter Petrow; Klaus M Hummel; J Schedel; Juliane K Franz; C L Klein; Ulf Müller-Ladner; Jörg Kriegsmann; P L Chang; C W Prince; Renate E Gay; Steffen Gay
Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.
Arthritis and rheumatism 2000;43(7):1597-605.
2000: Thomas Pap; Yukio Shigeyama; Stefan Kuchen; J K Fernihough; B Simmen; Renate E Gay; Michael E J Billingham; Steffen Gay
Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(6):1226-32.
2000: Michel Neidhart; Ulf Müller-Ladner; Walter Frey; Anja Bosserhoff; P C Colombani; P Frey-Rindova; Klaus M Hummel; Renate E Gay; Hans Jörg Häuselmann; Steffen Gay
Increased serum levels of non-collagenous matrix proteins (cartilage oligomeric matrix protein and melanoma inhibitory activity) in marathon runners.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(3):222-9.
2000: Thomas Pap; Renate E Gay; Steffen Gay
Gene transfer: from concept to therapy.
Current opinion in rheumatology 2000;12(3):205-10.
2000: Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Activation of synoviocytes.
Current opinion in rheumatology 2000;12(3):186-94.
2000: Ulf Müller-Ladner; Martin Judex; W Ballhorn; Frank Kullmann; Oliver Distler; Klaus Schlottmann; Renate E Gay; Jurgen Schölmerich; Steffen Gay
Activation of the IL-4 STAT pathway in rheumatoid synovium.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3894-901.
2000: Juliane K Franz; Thomas Pap; Klaus M Hummel; Michael Nawrath; Wilhelm K Aicher; Yukio Shigeyama; Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(3):599-607.
2000: Haiko Sprott; Ulf Müller-Ladner; Oliver Distler; Renate E Gay; S R Barnum; M Landthaler; J Schölmerich; B Lang; Steffen Gay
Detection of activated complement complex C5b-9 and complement receptor C5a in skin biopsies of patients with systemic sclerosis (scleroderma).
The Journal of rheumatology 2000;27(2):402-4.
2000: Thomas Pap; Juliane K Franz; Klaus M Hummel; E Jeisy; Renate E Gay; Steffen Gay
Activation of synovial fibroblasts in rheumatoid arthritis: lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destruction.
Arthritis research 2000;2(1):59-64.
2000: C Guincamp; Thomas Pap; Jörg Schedel; Géza Pap; U Moller-Ladner; Renate E Gay; Steffen Gay
Gene therapy in osteoarthritis.
Joint, bone, spine : revue du rhumatisme 2000;67(6):570-1.
2000: Thomas Pap; U Müller-Ladner; Renate E Gay; Steffen Gay
Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis.
Arthritis research 2000;2(5):361-7.
1999: O Distler; Ulf Müller-Ladner; Jurgen Schölmerich; Renate E Gay; Steffen Gay
[Rheumatoid arthritis: new molecular and cellular aspects].
Medizinische Klinik (Munich, Germany : 1983) 1999;94(12):673-80.
1999: Michel Neidhart; Renate E Gay; Steffen Gay
Prolactin and prolactin-like polypeptides in rheumatoid arthritis.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1999;53(5-6):218-22.
1999: Steffen Gay; Ulf Müller-Ladner; Klaus M Hummel; Thomas Pap; Renate E Gay
Anticytokines.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):317-8.
1999: Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Signaling and effector pathways.
Current opinion in rheumatology 1999;11(3):194-201.
1999: Michel Neidhart; R Wehrli; Pius Brühlmann; Beat A Michel; Renate E Gay; Steffen Gay
Synovial fluid CD146 (MUC18), a marker for synovial membrane angiogenesis in rheumatoid arthritis.
Arthritis and rheumatism 1999;42(4):622-30.
1999: Ulf Müller-Ladner; C H Evans; B N Franklin; Charles Roberts; Renate E Gay; P D Robbins; Steffen Gay
Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model.
Arthritis and rheumatism 1999;42(3):490-7.
1999: Michel Neidhart; Stefan Kuchen; Oliver Distler; Pius Brühlmann; Beat A Michel; Renate E Gay; Steffen Gay
Increased serum levels of antibodies against human cytomegalovirus and prevalence of autoantibodies in systemic sclerosis.
Arthritis and rheumatism 1999;42(2):389-92.
1999: Thomas Pap; U Müller-Ladner; Renate E Gay; Steffen Gay
Gene therapy in rheumatoid arthritis: how to target joint destruction?
Arthritis research 1999;1(1):5-9.
1999: Gaye Cunnane; Oliver FitzGerald; Klaus M Hummel; Renate E Gay; Steffen Gay; Barry Bresnihan
Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis.
Rheumatology (Oxford, England) 1999;38(1):34-42.
1999: Thomas Pap; Géza Pap; Klaus M Hummel; Juliane K Franz; E Jeisy; I Sainsbury; Renate E Gay; Michael E J Billingham; Wolfram Neumann; Steffen Gay
Membrane-type-1 matrix metalloproteinase is abundantly expressed in fibroblasts and osteoclasts at the bone-implant interface of aseptically loosened joint arthroplasties in situ.
The Journal of rheumatology 1999;26(1):166-9.
1998: Thomas Pap; Renate E Gay; Steffen Gay
Do antivirals have any utility in the treatment of arthritis?
Expert opinion on investigational drugs 1998;7(11):1841-8.
1998: Klaus M Hummel; Peter Petrow; Juliane K Franz; Ulf Müller-Ladner; Wilhelm K Aicher; Renate E Gay; D Brömme; Steffen Gay
Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.
The Journal of rheumatology 1998;25(10):1887-94.
1998: Juliane K Franz; SA Kolb; Klaus M Hummel; F Lahrtz; Michel Neidhart; Wilhelm K Aicher; Thomas Pap; Renate E Gay; Adriano Fontana; Steffen Gay
Interleukin-16, produced by synovial fibroblasts, mediates chemoattraction for CD4+ T lymphocytes in rheumatoid arthritis.
European journal of immunology 1998;28(9):2661-71.
1998: Haiko Sprott; LA Bradley; S J Oh; W Wintersberger; G S Alarcón; HG Mussell; A Tseng; Renate E Gay; Steffen Gay
Immunohistochemical and molecular studies of serotonin, substance P, galanin, pituitary adenylyl cyclase-activating polypeptide, and secretoneurin in fibromyalgic muscle tissue.
Arthritis and rheumatism 1998;41(9):1689-94.
1998: Klaus M Hummel; Michel Neidhart; Vkadimir Vilim; N Hauser; Wilhelm K Aicher; Renate E Gay; Steffen Gay; Hans Jörg Häuselmann
Analysis of cartilage oligomeric matrix protein (COMP) in synovial fibroblasts and synovial fluids.
British journal of rheumatology 1998;37(7):721-8.
1998: Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Molecular biology of cartilage and bone destruction.
Current opinion in rheumatology 1998;10(3):212-9.
1998: U Müller-Ladner; Renate E Gay; Steffen Gay
Retroviral sequences in rheumatoid arthritis synovium.
International reviews of immunology 1998;17(5-6):273-90.
1998: Gaye Cunnane; Klaus M Hummel; U Muller-Ladner; Renate E Gay; Steffen Gay
Mechanism of joint destruction in rheumatoid arthritis.
Archivum immunologiae et therapiae experimentalis 1998;46(1):1-7.
1997: Ulf Müller-Ladner; MJ Elices; J B Kriegsmann; D Strahl; Renate E Gay; Gary S Firestein; Steffen Gay
Alternatively spliced CS-1 fibronectin isoform and its receptor VLA-4 in rheumatoid arthritis synovium.
The Journal of rheumatology 1997;24(10):1873-80.
1997: Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Cellular pathways of joint destruction.
Current opinion in rheumatology 1997;9(3):213-20.
1997: Ulf Müller-Ladner; Charles Roberts; B N Franklin; Renate E Gay; P D Robbins; C H Evans; Steffen Gay
Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3492-8.
1997: K M Hummel; Renate E Gay; Steffen Gay
Novel strategies for the therapy of rheumatoid arthritis.
British journal of rheumatology 1997;36(2):265-7.
1996: Ulf Müller-Ladner; J Kriegsmann; B N Franklin; S Matsumoto; T Geiler; Renate E Gay; Steffen Gay
Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice.
The American journal of pathology 1996;149(5):1607-15.
1996: S Matsumoto; Ulf Müller-Ladner; Renate E Gay; K Nishioka; Steffen Gay
Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts.
The Journal of rheumatology 1996;23(8):1345-52.
1996: Ulf Müller-Ladner; J Kriegsmann; Renate E Gay; Steffen Gay
A one-day double-labelling technique for tissue specimens: immunogold-silver staining for in situ hybridization combined with alkaline phosphatase-anti-alkaline phosphatase (APAAP) immunohistochemistry for antigens.
The Histochemical journal 1996;28(2):133-4.
1996: J Kriegsmann; B N Franklin; Renate E Gay; J D Taurog; R E Hammer; Rolf Bräuer; D Katenkamp; Steffen Gay
[Fusion of vertebrae and the sacroiliac joint by cartilaginous tissue in HLA-B27 transgenic rats].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1996;80():334.
1996: Ulf Müller-Ladner; J Kriegsmann; D Strahl; Renate E Gay; M Elices; Steffen Gay
[Messenger RNA expression of alternatively spliced CS-1 fibronectin isoforms in Rheumatoid arthritis (RA) synovium].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1996;80():329.
1996: J Kriegsmann; Ulf Müller-Ladner; B N Franklin; S Matsumoto; T Geiler; Renate E Gay; Rolf Bräuer; D Katenkamp; Steffen Gay
[Synovial fibroblasts from patients with rheumatoid arthritis transplanted in SCID mice destroy normal human cartilage and expressed VCAM-1 and cathepsins].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1996;80():281.
1995: Ulf Müller-Ladner; J Kriegsmann; Renate E Gay; William J Koopman; Steffen Gay; W W Chatham
Progressive joint destruction in a human immunodeficiency virus-infected patient with rheumatoid arthritis.
Arthritis and rheumatism 1995;38(9):1328-32.
1995: Ulf Müller-Ladner; J Kriegsmann; Renate E Gay; Steffen Gay
Oncogenes in rheumatoid arthritis.
Rheumatic diseases clinics of North America 1995;21(3):675-90.
1995: A Trabandt; Ulf Müller-Ladner; J Kriegsmann; Renate E Gay; Steffen Gay
Expression of proteolytic cathepsins B, D, and L in periodontal gingival fibroblasts and tissues.
Laboratory investigation; a journal of technical methods and pathology 1995;73(2):205-12.
1995: Gernot Keyszer; A H Heer; J Kriegsmann; T Geiler; A Trabandt; M Keysser; Renate E Gay; Steffen Gay
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Arthritis and rheumatism 1995;38(7):976-84.
1995: J Kriegsmann; Gernot Keyszer; T Geiler; A S Lagoo; S Lagoo-Deenadayalan; Renate E Gay; Steffen Gay
Expression of E-selectin messenger RNA and protein in rheumatoid arthritis.
Arthritis and rheumatism 1995;38(6):750-4.
1995: A Trabandt; Renate E Gay; V P Sikhatme; Steffen Gay
Enzymatic detection systems for non-isotopic in situ hybridization using biotinylated cDNA probes.
The Histochemical journal 1995;27(4):280-90.
1995: Ulf Müller-Ladner; J Kriegsmann; J Tschopp; Renate E Gay; Steffen Gay
Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis.
Arthritis and rheumatism 1995;38(4):477-84.
1995: Gernot Keyszer; A H Heer; J Kriegsmann; T Geiler; C Keysser; Renate E Gay; Steffen Gay
Detection of insulin-like growth factor I and II in synovial tissue specimens of patients with rheumatoid arthritis and osteoarthritis by in situ hybridization.
The Journal of rheumatology 1995;22(2):275-81.
1995: J Kriegsmann; Gernot Keyszer; T Geiler; Rolf Bräuer; Renate E Gay; Steffen Gay
Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry.
Laboratory investigation; a journal of technical methods and pathology 1995;72(2):209-14.
1995: Ulf Müller-Ladner; J Kriegsmann; T Geiler; Renate E Gay; Steffen Gay
Synovial mesenchymal reaction as a perpetuating principle.
Scandinavian journal of rheumatology. Supplement 1995;101():115-9.
1994: J Kriegsmann; Gernot Keyszer; T Geiler; Renate E Gay; Steffen Gay
A new double labeling technique for combined in situ hybridization and immunohistochemical analysis.
Laboratory investigation; a journal of technical methods and pathology 1994;71(6):911-7.
1994: T Geiler; J Kriegsmann; Gernot Keyszer; Renate E Gay; Steffen Gay
A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice.
Arthritis and rheumatism 1994;37(11):1664-71.
1994: Steffen Gay; D W Boulware; Renate E Gay
Oncogenes, growth factors, and matrix in the pathogenesis of systemic sclerosis.
Clinics in dermatology 1994;12(3):419-24.
1994: Wilhelm K Aicher; A H Heer; A Trabandt; S L Bridges; Harry Schroeder; G Stransky; Renate E Gay; Hermann Eibel; H H Peter; U Siebenlist
Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5940-8.
1994: A H Heer; Gernot Keyszer; Renate E Gay; Steffen Gay
Inhibition of RNA polymerases by digoxigenin-labeled UTP.
BioTechniques 1994;16(1):54-5.
1993: G Stransky; J Vernon; Wilhelm K Aicher; Larry W Moreland; Renate E Gay; Steffen Gay
Virus-like particles in synovial fluids from patients with rheumatoid arthritis.
British journal of rheumatology 1993;32(12):1044-8.
1992: A Trabandt; Renate E Gay; Steffen Gay
Oncogene activation in rheumatoid synovium.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1992;100(10):861-75.
1992: A Trabandt; Renate E Gay; V P Sukhatme; Steffen Gay
Expression of collagenase and potential transcriptional factors c-fos and egr-1 in periodontal gingival fibroblasts.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 1992;21(5):232-40.
1992: Steffen Gay; A Trabandt; Larry W Moreland; Renate E Gay
Growth factors, extracellular matrix, and oncogenes in scleroderma.
Arthritis and rheumatism 1992;35(3):304-10.
1992: A Trabandt; Renate E Gay; H Birkedal-Hansen; Steffen Gay
Expression of collagenase and potential transcriptional factors in the MRL/l mouse arthropathy.
Seminars in arthritis and rheumatism 1992;21(4):246-51.
1992: A Trabandt; Renate E Gay; H Birkedal-Hansen; Steffen Gay
Ultrastructural pathway of human fibroblast collagenase and distribution in tissues of rheumatoid joint destruction.
Matrix (Stuttgart, Germany). Supplement 1992;1():395-6.
1992: A Trabandt; Wilhelm K Aicher; Renate E Gay; V P Sukhatme; H G Fassbender; Steffen Gay
Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts.
Rheumatology international 1992;12(2):53-9.
1991: A Trabandt; Renate E Gay; H G Fassbender; Steffen Gay
Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis.
Arthritis and rheumatism 1991;34(11):1444-51.
1990: A Trabandt; Wilhelm K Aicher; Renate E Gay; V P Sukhatme; M Nilson-Hamilton; R T Hamilton; J R McGhee; H G Fassbender; Steffen Gay
Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis.
Matrix (Stuttgart, Germany) 1990;10(6):349-61.
1990: A Trabandt; Renate E Gay; H Birkedal-Hansen; Steffen Gay
Intracellular secretory pathway and ultrastructural localization of interstitial procollagenase in human gingival fibroblasts.
Matrix (Stuttgart, Germany) 1990;10(5):339-47.
1989: Larry W Moreland; T Stewart; Renate E Gay; G Q Huang; N McGee; Steffen Gay
Immunohistologic demonstration of type II collagen in synovial fluid phagocytes of osteoarthritis and rheumatoid arthritis patients.
Arthritis and rheumatism 1989;32(11):1458-64.
1989: B Ziegler; Renate E Gay; G Q Huang; H G Fassbender; Steffen Gay
Immunohistochemical localization of HTLV-I p19- and p24-related antigens in synovial joints of patients with rheumatoid arthritis.
The American journal of pathology 1989;135(1):1-5.
1989: Steffen Gay; R E Jones; G Q Huang; Renate E Gay
Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma.
The Journal of investigative dermatology 1989;92(2):301-3.
1989: Steffen Gay; Renate E Gay
Cellular basis and oncogene expression of rheumatoid joint destruction.
Rheumatology international 1989;9(3-5):105-13.