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David Gaylor

Research Profile

Chemicals & Drugs

Concepts & Ideas

Living Beings

Procedures

Disorders

Phenomena

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United States

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United States Food and Drug Administration

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Publications

TOP 3
Stepan Melnyk; Oleksandra Pavliv; Shannon Rose; Eldon Schulz; Lisa Seidel; Jayne Bellando; George J Fuchs; Jill J Fussell; David W Gaylor; Stephen G Kahler; Maya Lopez; S Jill James
Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism.
S Jill James; Stepan Melnyk; Stefanie Jernigan; Oleksandra Pavliv; Timothy Trusty; Sara Lehman; Lisa Seidel; David W Gaylor; Mario A Cleves
A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism.
S Jill James; Shannon Rose; Stepan Melnyk; Stefanie Jernigan; Sarah Blossom; Oleksandra Pavliv; David W Gaylor
Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism.

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All Publications

2012: Stepan Melnyk; Oleksandra Pavliv; Shannon Rose; Eldon Schulz; Lisa Seidel; Jayne Bellando; George J Fuchs; Jill J Fussell; David W Gaylor; Stephen G Kahler; Maya Lopez; S Jill James
Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism.
Journal of autism and developmental disorders 2012;42(3):367-77.
2010: S Jill James; Stepan Melnyk; Stefanie Jernigan; Oleksandra Pavliv; Timothy Trusty; Sara Lehman; Lisa Seidel; David W Gaylor; Mario A Cleves
A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(6):1209-20.
2009: S Jill James; Shannon Rose; Stepan Melnyk; Stefanie Jernigan; Sarah Blossom; Oleksandra Pavliv; David W Gaylor
Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2374-83.
2009: S Jill James; Stepan Melnyk; George Fuchs; Tyra Reid; Stefanie Jernigan; Oleksandra Pavliv; Amanda Hubanks; David W Gaylor
Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism.
The American journal of clinical nutrition 2009;89(1):425-30.
2008: S Jill James; Stepan Melnyk; Stefanie Jernigan; Amanda Hubanks; Shannon Rose; David W Gaylor
Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism.
Journal of autism and developmental disorders 2008;38(10):1976.
2008: S Jill James; S Jill James; Stepan Melnyk; Stefanie Jernigan; Amanda Hubanks; Shannon Rose; David W Gaylor
Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism.
Journal of autism and developmental disorders 2008;38(10):1966-75.
2008: Werner K Lutz; David W Gaylor
Dose-response relationships for cancer incidence reflect susceptibility distributions.
Chemical research in toxicology 2008;21(5):971-2; author reply 972-3.
2005: Richard Reiss; David W Gaylor
Use of benchmark dose and meta-analysis to determine the most sensitive endpoint for risk assessment for dimethoate.
Regulatory toxicology and pharmacology : RTP 2005;43(1):55-65.
2004: Hojin Moon; Chun-houh Chen; David W Gaylor; Ralph L Kodell
A comparison of microbial dose-response models fitted to human data.
Regulatory toxicology and pharmacology : RTP 2004;40(2):177-84.
2002: David W Gaylor; Ralph L Kodell
A procedure for developing risk-based reference doses.
Regulatory toxicology and pharmacology : RTP 2002;35(2 Pt 1):137-41.
2001: Robert M Blair; Hong Fang; David W Gaylor; Daniel M Sheehan
Threshold analysis of selected dose-response data for endocrine active chemicals.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2001;109(3):198-208.
2001: Ralph L Kodell; John F Young; Robert R Delongchamp; Angelo Turturro; J J Chen; David W Gaylor; Paul C Howard; Q Zheng
A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1 in the diet.
Food additives and contaminants 2001;18(3):237-53.
2001: David W Gaylor; Ralph L Kodell
Dose-response trend tests for tumorigenesis adjusted for differences in survival and body weight across doses.
Toxicological sciences : an official journal of the Society of Toxicology 2001;59(2):219-25.
2000: David W Gaylor
The use of Haber's law in standard setting and risk assessment.
Toxicology 2000;149(1):17-9.
2000: David W Gaylor
New issues in cancer risk assessment.
Drug metabolism reviews 2000;32(2):187-92.
2000: David W Gaylor; Ralph L Kodell
Percentiles of the product of uncertainty factors for establishing probabilistic reference doses.
Risk analysis : an official publication of the Society for Risk Analysis 2000;20(2):245-50.
2000: David W Gaylor; Sandra J Culp; Lawrence S Goldstein; Frederick A Beland
Cancer risk estimation for mixtures of coal tars and benzo(a)pyrene.
Risk analysis : an official publication of the Society for Risk Analysis 2000;20(1):81-5.
1999: David W Gaylor; Ralph L Kodell; J J Chen
Human cancer risk estimates are reduced when based on relative risk for common rodent tumors.
Regulatory toxicology and pharmacology : RTP 1999;30(3):283-4.
1999: L A Poirier; D R Doerge; David W Gaylor; M A Miller; R J Lorentzen; D A Casciano; F F Kadlubar; BA Schwetz
An FDA review of sulfamethazine toxicity.
Regulatory toxicology and pharmacology : RTP 1999;30(3):217-22.
1999: David W Gaylor; Ralph L Kodell; J J Chen; D Krewski
A unified approach to risk characterization.
Inhalation toxicology 1999;11(6-7):575-8.
1999: David W Gaylor; Ralph L Kodell
Dose-response trend tests for tumorigenesis, adjusted for body weight.
Toxicological sciences : an official journal of the Society of Toxicology 1999;49(2):318-23.
1999: David W Gaylor; Ralph L Kodell; Chun-houh Chen; D Krewski
A unified approach to risk assessment for cancer and noncancer endpoints based on benchmark doses and uncertainty/safety factors.
Regulatory toxicology and pharmacology : RTP 1999;29(2 Pt 1):151-7.
1999: Daniel M Sheehan; Emily J Willingham; David W Gaylor; Judith M Bergeron; David Crews
No threshold dose for estradiol-induced sex reversal of turtle embryos: how little is too much?
Environmental health perspectives 1999;107(2):155-9.
1999: Ralph L Kodell; David W Gaylor
Combining uncertainty factors in deriving human exposure levels of noncarcinogenic toxicants.
Annals of the New York Academy of Sciences 1999;895():188-95.
1998: David W Gaylor; L Swirsky Gold
Regulatory cancer risk assessment based on a quick estimate of a benchmark dose derived from the maximum tolerated dose.
Regulatory toxicology and pharmacology : RTP 1998;28(3):222-5.
1998: Lawrence S Goldstein; Eric H Weyand; Stephen Safe; M Steinberg; Sandra J Culp; David W Gaylor; Frederick A Beland; Lewis V Rodriguez
Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: implications for risk assessment.
Environmental health perspectives 1998;106 Suppl 6():1325-30.
1998: David W Gaylor; S Moolgavkar; D Krewski; Lawrence S Goldstein
Recent bioassay results on coal tars and benzo(a)pyrene: implications for risk assessment.
Regulatory toxicology and pharmacology : RTP 1998;28(2):178-9.
1998: David W Gaylor; L Ryan; D Krewski; Y Zhu
Procedures for calculating benchmark doses for health risk assessment.
Regulatory toxicology and pharmacology : RTP 1998;28(2):150-64.
1998: David W Gaylor
Safety assessment with hormetic effects.
Human & experimental toxicology 1998;17(5):251-3.
1998: David W Gaylor; P M Bolger; BA Schwetz
U.S. Food and Drug Administration perspective of the inclusion of effects of low-level exposures in safety and risk assessment.
Environmental health perspectives 1998;106 Suppl 1():391-4.
1998: S Jill James; Levan Muskhelishvili; David W Gaylor; Angelo Turturro; R Hart
Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging.
Environmental health perspectives 1998;106 Suppl 1():307-12.
1998: Sandra J Culp; David W Gaylor; W G Sheldon; Lawrence S Goldstein; Frederick A Beland
A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay.
Carcinogenesis 1998;19(1):117-24.
1997: David W Gaylor; J A Axelrad; R P Brown; J A Cavagnaro; W H Cyr; K L Hulebak; R J Lorentzen; M A Miller; L T Mulligan; BA Schwetz
Health risk assessment practices in the U.S. Food and Drug Administration.
Regulatory toxicology and pharmacology : RTP 1997;26(3):307-21.
1997: David W Gaylor; Q Zheng
A note on the relationship between lifetime tumor risk and expected time to tumor.
Risk analysis : an official publication of the Society for Risk Analysis 1997;17(1):5-7.
1996: David W Gaylor
Quantalization of continuous data for benchmark dose estimation.
Regulatory toxicology and pharmacology : RTP 1996;24(3):246-50.
1996: David W Gaylor; J J Chen
Precision of benchmark dose estimates for continuous (nonquantal) measurements of toxic effects.
Regulatory toxicology and pharmacology : RTP 1996;24(1 Pt 1):19-23.
1996: R L Kodell; A P Basu; David W Gaylor
On interspecies correlations of carcinogenic potencies.
Journal of toxicology and environmental health 1996;48(3):231-7.
1996: David W Gaylor; J J Chen
A simple upper limit for the sum of the risks of the components in a mixture.
Risk analysis : an official publication of the Society for Risk Analysis 1996;16(3):395-8.
1996: A P Basu; David W Gaylor; J J Chen
Estimating the probability of occurrence of tumor for a rare cancer with zero occurrence in a sample.
Regulatory toxicology and pharmacology : RTP 1996;23(2):139-44.
1996: David W Gaylor; Q Zheng
Risk assessment of nongenotoxic carcinogens based upon cell proliferation/death rates in rodents.
Risk analysis : an official publication of the Society for Risk Analysis 1996;16(2):221-5.
1996: M Razzaghi; David W Gaylor
On the correlation coefficient between the TD50 and the MTD.
Risk analysis : an official publication of the Society for Risk Analysis 1996;16(1):107-13.
1995: William Slikker; David W Gaylor
Biologically based dose-response model for neurotoxicity risk assessment.
Annals of the New York Academy of Sciences 1995;765():339.
1995: David W Gaylor; L S Gold
Quick estimate of the regulatory virtually safe dose based on the maximum tolerated dose for rodent bioassays.
Regulatory toxicology and pharmacology : RTP 1995;22(1):57-63.
1994: David W Gaylor; R L Kodell; J J Chen; J A Springer; R J Lorentzen; R J Scheuplein
Point estimates of cancer risk at low doses.
Risk analysis : an official publication of the Society for Risk Analysis 1994;14(5):843-50.
1994: David W Gaylor; William Slikker
Modeling for risk assessment of neurotoxic effects.
Risk analysis : an official publication of the Society for Risk Analysis 1994;14(3):333-8.
1994: R W West; W G Sheldon; David W Gaylor; R R Allen; Fred F Kadlubar
Study of sodium saccharin co-carcinogenicity in the rat.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(3):207-13.
1993: David W Gaylor; J J Chen; D M Sheehan
Uncertainty in cancer risk estimates.
Risk analysis : an official publication of the Society for Risk Analysis 1993;13(2):149-54.
1993: David W Gaylor; J J Chen
Dose-response models for developmental malformations.
Teratology 1993;47(4):291-7.
1992: David W Gaylor; M Razzaghi
Process of building biologically based dose-response models for developmental defects.
Teratology 1992;46(6):573-81.
1992: David W Gaylor; Fred F Kadlubar; Frederick A Beland
Application of biomarkers to risk assessment.
Environmental health perspectives 1992;98():139-41.
1992: J F Holson; T B Gaines; C J Nelson; J B LaBorde; David W Gaylor; Daniel M Sheehan; J F Young
Developmental toxicity of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). I. Multireplicated dose-response studies in four inbred strains and one outbred stock of mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1992;19(2):286-97.
1992: David W Gaylor
Incidence of developmental defects at the no observed adverse effect level (NOAEL).
Regulatory toxicology and pharmacology : RTP 1992;15(2 Pt 1):151-60.
1992: J J Chen; David W Gaylor
Correlations of developmental end points observed after 2,4,5-trichlorophenoxyacetic acid exposure in mice.
Teratology 1992;45(3):241-6.
1991: R L Kodell; R B Howe; J J Chen; David W Gaylor
Mathematical modeling of reproductive and developmental toxic effects for quantitative risk assessment.
Risk analysis : an official publication of the Society for Risk Analysis 1991;11(4):583-90.
1991: J J Chen; R L Kodell; R B Howe; David W Gaylor
Analysis of trinomial responses from reproductive and developmental toxicity experiments.
Biometrics 1991;47(3):1049-58.
1991: George Wolff; David W Gaylor; B N Blackwell; G E Moore
Bladder and liver tumorigenesis induced by 2-acetylaminofluorene in different F1 mouse hybrids: variation within genotypes and effects of using more than one genotype on risk assessment.
Journal of toxicology and environmental health 1991;33(3):327-48.
1991: R L Kodell; David W Gaylor; J J Chen
Carcinogenic potency correlations: real or artifactual?
Journal of toxicology and environmental health 1991;32(1):1-9.
1990: J J Chen; David W Gaylor; R L Kodell
Estimation of the joint risk for multiple-compound exposure based on single-compound experiments.
Risk analysis : an official publication of the Society for Risk Analysis 1990;10(2):285-90.
1990: N A Littlefield; W G Sheldon; R Allen; David W Gaylor
Chronic toxicity/carcinogenicity studies of sulphamethazine in Fischer 344/N rats: two-generation exposure.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1990;28(3):157-67.
1989: David W Gaylor
Comparison of teratogenic and carcinogenic risks.
Regulatory toxicology and pharmacology : RTP 1989;10(2):138-43.
1989: N A Littlefield; David W Gaylor; B N Blackwell; R R Allen
Chronic toxicity/carcinogenicity studies of sulphamethazine in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1989;27(7):455-63.
1989: N A Littlefield; David W Gaylor; B N Blackwell; R R Allen
Chronic toxicity/carcinogenicity studies of gentian violet in Fischer 344 rats: two-generation exposure.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1989;27(4):239-47.
1989: R L Kodell; J J Chen; David W Gaylor
A note on the role of background tumor incidence in risk assessment for carcinogens.
Regulatory toxicology and pharmacology : RTP 1989;9(2):141-6.
1989: David W Gaylor
Preliminary estimates of the virtually safe dose for tumors obtained from the maximum tolerated dose.
Regulatory toxicology and pharmacology : RTP 1989;9(2):101-8.
1989: R P Felton; David W Gaylor
Multistrain experiments for screening toxic substances.
Journal of toxicology and environmental health 1989;26(4):399-411.
1988: J J Chen; R L Kodell; David W Gaylor
Using the biological two-stage model to assess risk from short-term exposures.
Risk analysis : an official publication of the Society for Risk Analysis 1988;8(2):223-30.
1986: R W West; W G Sheldon; David W Gaylor; M G Haskin; R R Delongchamp; Fred F Kadlubar
The effects of saccharin on the development of neoplastic lesions initiated with N-methyl-N-nitrosourea in the rat urothelium.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1986;7(4):585-600.
1985: N A Littlefield; B N Blackwell; C C Hewitt; David W Gaylor
Chronic toxicity and carcinogenicity studies of gentian violet in mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1985;5(5):902-12.
1985: David W Gaylor; D L Greenman; C H Frith
Urinary bladder neoplasms induced in BALB/c female mice with low doses of 2-acetylaminofluorene.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 1985;6(1):127-36.
1984: N A Littlefield; C J Nelson; David W Gaylor
Benzidine dihydrochloride: risk assessment.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1984;4(1):69-80.
1983: George Wolff; David W Gaylor; C H Frith; R L Suber
Controlled genetic variation in a subchronic toxicity assay: susceptibility to induction of bladder hyperplasia in mice by 2-acetylaminofluorene.
Journal of toxicology and environmental health 1983;12(2-3):255-65.
1983: R L Kodell; David W Gaylor; D L Greenman; N A Littlefield; J H Farmer
Response to the society of toxicology task force re-examination of the ED01 study.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1983;3(4):3a-12a.
1982: R L Kodell; J H Farmer; David W Gaylor; A M Cameron
Influence of cause-of-death assignment on time-to-tumor analyses in animal carcinogenesis studies.
Journal of the National Cancer Institute 1982;69(3):659-64.
1980: N A Littlefield; J H Farmer; David W Gaylor; W G Sheldon
Effects of dose and time in a long-term, low-dose carcinogenic study.
Journal of environmental pathology and toxicology 1980;3(3 Spec No):17-34.

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