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Adi Gazdar

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Kazuhiko Shien; Junichi Soh; Nagio Takigawa; Kelsie L Thu; Shinichi Toyooka; Kazunori Tsukuda; Hiromasa Yamamoto; Hiroaki Asano; Adi F Gazdar; Shinsuke Hashida; Eiki Ichihara; Masaru Jida; Katsuyuki Kiura; Wan L Lam; Yuho Maki; Shinichiro Miyoshi
Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell-like Properties in Cancer Cells.
Santanu Dasgupta; Paul B Fisher; Adi F Gazdar; Mohammad Hoque; Jin Sung Jang; Jin Jen; Stephan Lam; Nitai D Mukhopadhyay; Chunbo Shao; Upneet K Sokhi; C Conover Talbot; William H Westra; Ping Yang; Joanne E Yi; Rex C-W Yung; Shahnaz Begum; Mariana Brait; Swadesh K Das; David Sidransky
SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.
Momen Elshazley; Adi F Gazdar; Tetsunari Hase; Futoshi Ishiguro; Masashi Kondo; John D Minna; Hirotaka Osada; Mitsuo Sato; Yoshitaka Sekido; David S Shames; Shinya Toyokuni; Noriyasu Usami; Ryo Yamashita; Kohei Yokoi; Kenya Yoshida; Yoshinori Hasegawa
The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma.

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All Publications

2013: Kazuhiko Shien; Junichi Soh; Nagio Takigawa; Kelsie L Thu; Shinichi Toyooka; Kazunori Tsukuda; Hiromasa Yamamoto; Hiroaki Asano; Adi F Gazdar; Shinsuke Hashida; Eiki Ichihara; Masaru Jida; Katsuyuki Kiura; Wan L Lam; Yuho Maki; Shinichiro Miyoshi
Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell-like Properties in Cancer Cells.
Cancer research 2013;73(10):3051-61.
2013: Santanu Dasgupta; Paul B Fisher; Adi F Gazdar; Mohammad Hoque; Jin Sung Jang; Jin Jen; Stephan Lam; Nitai D Mukhopadhyay; Chunbo Shao; Upneet K Sokhi; C Conover Talbot; William H Westra; Ping Yang; Joanne E Yi; Rex C-W Yung; Shahnaz Begum; Mariana Brait; Swadesh K Das; David Sidransky
SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.
Journal of molecular medicine (Berlin, Germany) 2013;91(3):381-93.
2012: Momen Elshazley; Adi F Gazdar; Tetsunari Hase; Futoshi Ishiguro; Masashi Kondo; John D Minna; Hirotaka Osada; Mitsuo Sato; Yoshitaka Sekido; David S Shames; Shinya Toyokuni; Noriyasu Usami; Ryo Yamashita; Kohei Yokoi; Kenya Yoshida; Yoshinori Hasegawa
The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma.
International journal of cancer. Journal international du cancer 2012;131(12):2820-31.
2012: Yibing Yao; Yu Fan; Adi F Gazdar; Luc Girard; Stephen Lam; Wan L Lam; Haisu Wan; Jing Wang; Jun Wu; Zhihao Wu; Qinghua Zhou
Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis.
Biochemical and biophysical research communications 2012;423(3):613-9.
2012: Suhaida A Selamat; Kimberly D Siegmund; Wei Zhang; Ying Zhang; Mihaela Campan; Brian S Chung; Adi F Gazdar; Luc Girard; Jeffrey A Hagen; Michael N Koss; Stephen Lam; Wan L Lam; Ite A Laird-Offringa
Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.
Genome research 2012;22(7):1197-211.
2012: Mihoko Horio; Masashi Kondo; John D Minna; Mitsuo Sato; Yoshitaka Sekido; Yoshihiro Takeyama; Shinya Toyokuni; Noriyasu Usami; Ryo Yamashita; Kohei Yokoi; Kenya Yoshida; Momen Elshazley; Adi F Gazdar; Tetsunari Hase; Yoshinori Hasegawa
Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells.
Annals of surgical oncology 2012;19 Suppl 3():S634-45.
2012: Santanu Dasgupta; Paul B Fisher; Adi F Gazdar; Stephan Lam; Reddy v Praveen; Nitai Mukhopadhyay; Chunbo Shao; Ethan Soudry; John Yee; Wei Zhang; David Sidransky
Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation.
Journal of cellular physiology 2012;227(6):2451-60.
2012: noriaki sunaga; Mitsuo Sato; David S Shames; Kimihiro Shimizu; Adi F Gazdar; Luc Girard; Hisao Imai; Tamotsu Ishizuka; Kyoichi Kaira; Seiichi Kakegawa; John D Minna; Masatomo Mori
Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer.
International journal of cancer. Journal international du cancer 2012;130(8):1733-44.
2012: Liqin Du; Adi F Gazdar; Rachel Greer; John D Minna; Jeoffrey J Schageman; Maria C Subauste; Milind Suraokar; Ignacio I Wistuba; Chin-Rang Yang; Zhenze Zhao; Michael Baker; Robert Borkowski; Christopher DeSevo; Alexander Pertsemlidis
miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers.
PloS one 2012;7(6):e39167.
2012: William W Lockwood; Calum E MacAulay; John D Minna; Nevin Murray; Maria I Nunez; Larissa A Pikor; Luisa M Solis; Kelsie L Thu; Ming-Sound Tsao; Ian M Wilson; Ignacio I Wistuba; John Yee; Carmen Behrens; Raj Chari; Bradley P Coe; John English; Adi F Gazdar; Stephen Lam; Wan L Lam
Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.
PloS one 2012;7(5):e37775.
2012: Kelsie L Thu; Emily A Vucic; Pei Wang; Wei Zhang; Raj Chari; John C English; Ziding Feng; Rong Fu; Adi F Gazdar; Stephen Lam; William W Lockwood; Calum E MacAulay; Wan L Lam
Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability.
PloS one 2012;7(3):e33003.
2012: Michele Carbone; Ronald F Dodson; Umran A Dogan; Adi F Gazdar; Bevan H Ly; Paul T Morris; Ian Pagano; Harvey I Pass; Haining Yang
Malignant mesothelioma: facts, myths, and hypotheses.
Journal of cellular physiology 2012;227(1):44-58.
2011: Shinichi Toyooka; Adi F Gazdar
Methylation profiling of lung cancer: a decade of progress.
Molecular cancer therapeutics 2011;10(11):2020.
2011: Daniel T Starczynowski; Ming-Sound Tsao; Joanna Wegrzyn; Stephen Lam; Wan L Lam; William W Lockwood; Raj Chari; Sophie Deléhouzée; Megan Fuller; Adi F Gazdar; Aly Karsan
TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer.
The Journal of clinical investigation 2011;121(10):4095-105.
2011: Yu-An Zhang; Rolf Brekken; Eugene Frenkel; Boning Gao; Luc Girard; Jer-Tsong Hsieh; Collins A Karikari; Anirban Maitra; John D Minna; CRAIG PEACOCK; Charles Rudin; Victor Stastny; Ignacio Wistuba; Adi F Gazdar
Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts.
Cancer biology & therapy 2011;12(7):617-28.
2011: Ayumu Taguchi; Harold E Varmus; Chee-Hong Wong; Qing Zhang; Alice Chin; Ronald A DePinho; Daniela M Dinulescu; Vitor M Faça; Adi F Gazdar; Gary Goodman; Karen Kelly-Spratt; Christopher J Kemp; Raju Kucherlapati; William W Lockwood; Kwon-Sik Park; Sharon J Pitteri; Katerina Politi; Julien Sage; Samir M Hanash
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
Cancer cell 2011;20(3):289-99.
2011: Kelsie L Thu; Ming-Sound Tsao; Ian M Wilson; Calum E Macaulay; Larissa A Pikor; Raj Chari; John C English; Adi F Gazdar; Stephen Lam; Wan L Lam; William W Lockwood
Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(9):1521-9.
2011: Adi F Gazdar; Yu-An Zhang
Research highlights.
Epigenomics 2011;3(4):405-7.
2011: Tetsunari Hase; Momen Elshazley; Adi F Gazdar; Luc Girard; Mihoko Horio; Masashi Kondo; John D Minna; Tomoyo Oguri; Mitsuo Sato; Yoshitaka Sekido; David S Shames; Yoshihiro Takeyama; Kenya Yoshida; Yoshinori Hasegawa
Pivotal role of epithelial cell adhesion molecule in the survival of lung cancer cells.
Cancer science 2011;102(8):1493-500.
2011: Adi F Gazdar
Tyrosine kinase inhibitors and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer: to test or not to test?
Medicine 2011;90(3):168-70.
2011: Ximing Tang; Humam Kadara; Carmen Behrens; Diane D Liu; Yun Xiao; David Rice; Adi F Gazdar; Junya Fujimoto; Cesar Moran; Marileila Varella-Garcia; J Jack Lee; Waun Ki Hong; Ignacio I Wistuba
Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2434-43.
2011: noriaki sunaga; David S Shames; Luc Girard; Michael Peyton; Jill Everland Larsen; Hisao Imai; Junichi Soh; Mitsuo Sato; Noriko Yanagitani; Kyoichi Kaira; Yang Xie; Adi F Gazdar; Masatomo Mori; John D Minna
Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy.
Molecular cancer therapeutics 2011;10(2):336-46.
2011: Masaharu Nomura; Tatsuo Ohira; Hisashi Oshiro; Hiromasa Tojo; Masahiro Tsuboi; Yasuhiko Bando; Kiyonaga Fujii; Tetsuya Fukuda; Adi F Gazdar; Noriko Gotoh; Norihiko Ikeda; Harubumi Kato; Takeshi Kawamura; Makoto Kihara; Gyorgy Marko-Varga; Toshitaka Nagao; Toshihide Nishimura
Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study.
Journal of clinical bioinformatics 2011;1(1):23.
2010: James P Sullivan; Monica Spinola; Michael Dodge; Maria G Raso; Carmen Behrens; Boning Gao; Katja Schuster; Chunli Shao; Jill E Larsen; Laura A Sullivan; Sofia Honorio; Yang Xie; Pier P Scaglioni; J Michael DiMaio; Adi F Gazdar; Jerry W Shay; Ignacio I Wistuba; John D Minna
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Cancer research 2010;70(23):9937-48.
2010: Yoshihiro Takeyama; Mitsuo Sato; Mihoko Horio; Tetsunari Hase; Kenya Yoshida; Toshihiko Yokoyama; Harunori Nakashima; Naozumi Hashimoto; Yoshitaka Sekido; Adi F Gazdar; John D Minna; Masashi Kondo; Yoshinori Hasegawa
Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells.
Cancer letters 2010;296(2):216-24.
2010: Adi F Gazdar
Should we continue to use the term non-small-cell lung cancer?
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2010;21 Suppl 7():vii225-9.
2010: Adi F Gazdar; Luc Girard; William W Lockwood; Wan L Lam; John D Minna
Lung cancer cell lines as tools for biomedical discovery and research.
Journal of the National Cancer Institute 2010;102(17):1310-21.
2010: Di Cai; David S Shames; Maria Gabriela Raso; Yang Xie; Young H Kim; Jonathan R Pollack; Luc Girard; James P Sullivan; Boning Gao; Michael Peyton; Meera Nanjundan; Lauren Byers; John Heymach; Gordon Mills; Adi F Gazdar; Ignacio Wistuba; Thomas Kodadek; John D Minna
Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation.
Cancer research 2010;70(16):6477-85.
2010: Adi F Gazdar; Paolo Boffetta
A risky business--identifying susceptibility loci for lung cancer.
Journal of the National Cancer Institute 2010;102(13):920-3.
2010: William W Lockwood; Raj Chari; Bradley P Coe; Kelsie L Thu; Cathie Garnis; Chad A Malloff; Jennifer Campbell; Ariane C Williams; Dorothy Hwang; Chang-Qi Zhu; Timon P H Buys; John Yee; John C English; Calum MacAulay; Ming-Sound Tsao; Adi F Gazdar; John D Minna; Stephen Lam; Wan L Lam
Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.
PLoS medicine 2010;7(7):e1000315.
2010: Elisa Benedettini; Lynette M Sholl; Michael Peyton; John Reilly; Christopher Ware; Lenora Davis; Natalie Vena; Dyane Bailey; Beow Y Yeap; Michelangelo Fiorentino; Azra H Ligon; Bo-Sheng Pan; Victoria M Richon; John D Minna; Adi F Gazdar; Giulio Draetta; Silvano Bosari; Lucian R Chirieac; Bart Lutterbach; Massimo Loda
Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis.
The American journal of pathology 2010;177(1):415-23.
2010: Adi F Gazdar; Boning Gao; John D Minna
Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?
Lung cancer (Amsterdam, Netherlands) 2010;68(3):309-18.
2010: Lei Xu; M B Nilsson; P Saintigny; T Cascone; Matthew H Herynk; Z Du; P G Nikolinakos; Ying Yang; Ludmila Prudkin; Diane Liu; J Jack Lee; Faye M Johnson; Kwong-Kwok Wong; L Girard; Adi F Gazdar; John D Minna; Jonathan M Kurie; Ignacio I Wistuba; John V Heymach
Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells.
Oncogene 2010;29(18):2616-27.
2010: Young-Hak Kim; K A Kwei; L Girard; Keyan Salari; J Kao; Manuela Pacyna-Gengelbach; Pei Wang; Tina Hernandez-Boussard; Adi F Gazdar; Iver Petersen; John D Minna; Jonathan R Pollack
Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer.
Oncogene 2010;29(10):1421-30.
2010: N Shivapurkar; Adi F Gazdar
DNA methylation based biomarkers in non-invasive cancer screening.
Current molecular medicine 2010;10(2):123-32.
2010: Adi F Gazdar
Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy.
Cancer metastasis reviews 2010;29(1):37-48.
2010: Raj Chari; Kelsie L Thu; Ian M Wilson; William W Lockwood; Kim M Lonergan; Bradley P Coe; Chad A Malloff; Adi F Gazdar; Stephen Lam; Cathie Garnis; Calum E MacAulay; Carlos E Alvarez; Wan L Lam
Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.
Cancer metastasis reviews 2010;29(1):73-93.
2010: Adi F Gazdar
Preface.
Cancer metastasis reviews 2010;29(1):3-4.
2010: Adi F Gazdar; Elisabeth Brambilla
Preneoplasia of lung cancer.
Cancer biomarkers : section A of Disease markers 2010;9(1-6):385-96.
2010: Liqin Du; Jeoffrey Schageman; Luc Girard; Scott M Hammond; John D Minna; Adi F Gazdar; Alexander Pertsemlidis
MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.
Journal of experimental & clinical cancer research : CR 2010;29():75.
2009: Georgia Konstantinidou; Erik A Bey; Andrea Rabellino; Katja Schuster; Michael S Maira; Adi F Gazdar; Augusto Amici; David A Boothman; Pier Paolo Scaglioni
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Cancer research 2009;69(19):7644-52.
2009: Adi F Gazdar
Personalized medicine and inhibition of EGFR signaling in lung cancer.
The New England journal of medicine 2009;361(10):1018-20.
2009: Adi F Gazdar
Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors.
Oncogene 2009;28 Suppl 1():S24-31.
2009: Pyng Lee; Remco M van den Berg; Stephen Lam; Adi F Gazdar; Katrien Grunberg; Annette McWilliams; Jean Leriche; Pieter E Postmus; Tom G Sutedja
Color fluorescence ratio for detection of bronchial dysplasia and carcinoma in situ.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(14):4700-5.
2009: Adi F Gazdar; John D Minna
Multifocal lung cancers--clonality vs field cancerization and does it matter?
Journal of the National Cancer Institute 2009;101(8):541-3.
2009: Martin L Sos; Mirjam Koker; Barbara A Weir; Stefanie Heynck; Rosalia Rabinovsky; Thomas Zander; Jens M Seeger; Jonathan Weiss; Florian Fischer; Peter Frommolt; Kathrin Michel; Martin Peifer; Craig Mermel; Luc Girard; Michael Peyton; Adi F Gazdar; John D Minna; Levi A Garraway; Hamid Kashkar; William Pao; Matthew Meyerson; Roman K Thomas
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR.
Cancer research 2009;69(8):3256-61.
2009: Takafumi Kubo; Hiromasa Yamamoto; William W Lockwood; Ilse Valencia; Junichi Soh; Michael Peyton; Masaru Jida; Hiroki Otani; Tetsuya Fujii; Mamoru Ouchida; Nagio Takigawa; Katsuyuki Kiura; Kenji Shimizu; Hiroshi Date; John D Minna; Marileila Varella-Garcia; Wan L Lam; Adi F Gazdar; Shinichi Toyooka
MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors.
International journal of cancer. Journal international du cancer 2009;124(8):1778-84.
2009: Wei Zhang; Michael Peyton; Yang Xie; Junichi Soh; John D Minna; Adi F Gazdar; Eugene P Frenkel
Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(2):161-6.
2009: Junichi Soh; Naoki Okumura; William W Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; John D Minna; Wan L Lam; Adi F Gazdar
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
PloS one 2009;4(10):e7464.
2009: Jessica Kao; Keyan Salari; Melanie Bocanegra; Yoon L. Choi; Luc Girard; Jeet Gandhi; Kevin A Kwei; Tina Hernandez-Boussard; Pei Wang; Adi F Gazdar; John D Minna; Jonathan R Pollack
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PloS one 2009;4(7):e6146.
2009: Jeet Gandhi; Jianling Zhang; Yang Xie; Junichi Soh; Hisayuki Shigematsu; Wei Zhang; Hiromasa Yamamoto; Michael Peyton; Luc Girard; William W Lockwood; Wan L Lam; Marileila Varella-Garcia; John D Minna; Adi F Gazdar
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
PloS one 2009;4(2):e4576.
2009: Norimasa Miura; Reina Sato; Tomoe Tsukamoto; Mika Shimizu; Hiroko Kabashima; Miho Takeda; Shunsaku Takahashi; Tomomi Harada; James E West; Harry A Drabkin; Jose E Mejia; Goshi Shiota; Yoshikazu Murawaki; Arvind Virmani; Adi F Gazdar; Mitsuo Oshimura; Junichi Hasegawa
A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT.
BMC molecular biology 2009;10():5.
2008: Narayan Shivapurkar; Victor Stastny; Naoki Okumura; Luc Girard; Yang Xie; Clemens Prinsen; Frederik B Thunnissen; Ignacio I Wistuba; Bogdan Czerniak; Eugene P Frenkel; Jack A Roth; Triantafillos Liloglou; George Xinarianos; John Field; John D Minna; Adi F Gazdar
Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.
Cancer research 2008;68(18):7448-56.
2008: Hiromasa Yamamoto; Hisayuki Shigematsu; Masaharu Nomura; William W Lockwood; Mitsuo Sato; Naoki Okumura; Junichi Soh; Makoto Suzuki; Ignacio I Wistuba; Kwun M Fong; Huei Lee; Shinichi Toyooka; Hiroshi Date; Wan L Lam; John D Minna; Adi F Gazdar
PIK3CA mutations and copy number gains in human lung cancers.
Cancer research 2008;68(17):6913-21.
2008: Adi F Gazdar; John D Minna
Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops.
Cancer prevention research (Philadelphia, Pa.) 2008;1(3):156-60.
2008: Shinichi Toyooka; Keitaro Matsuo; Adi F Gazdar
DNA methylation in lung cancer.
The New England journal of medicine 2008;358(23):2513; author reply 2514.
2008: Narayan Shivapurkar; Victor Stastny; Yang Xie; Clemens Prinsen; Eugene Frenkel; Bogdan Czerniak; Frederik B Thunnissen; John D Minna; Adi F Gazdar
Differential methylation of a short CpG-rich sequence within exon 1 of TCF21 gene: a promising cancer biomarker assay.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(4):995-1000.
2008: Junichi Soh; Shinichi Toyooka; Shuji Ichihara; Hiroaki Asano; Naruyuki Kobayashi; Hiroshi Suehisa; Hiroki Otani; Hiromasa Yamamoto; Kouichi Ichimura; Katsuyuki Kiura; Adi F Gazdar; Hiroshi Date
Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(4):340-7.
2008: Niels Eckstein; Kati Servan; Luc Girard; Di Cai; Georg von Jonquieres; Ulrich Jaehde; Matthias U Kassack; Adi F Gazdar; John D Minna; hans-dieter royer
Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells.
The Journal of biological chemistry 2008;283(2):739-50.
2007: James Bean; Cameron Brennan; Jin-Yuan Shih; Gregory J Riely; Agnes Viale; Lu Wang; Dhananjay Chitale; Noriko Motoi; Janos Szoke; Stephen Broderick; Marissa N Balak; Wen-Cheng Chang; Chong-Jen Yu; Adi F Gazdar; Harvey I Pass; Valerie W Rusch; William Gerald; Shiu-Feng Huang; Pan-Chyr Yang; Vincent A Miller; Marc Ladanyi; Chih-Hsin Yang; William Pao
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20932-7.
2007: Narayan Shivapurkar; Mark E Sherman; Victor Stastny; Chinyere Echebiri; Janet S Rader; Ritu Nayar; Thomas A Bonfiglio; Adi F Gazdar; Sophia S Wang
Evaluation of candidate methylation markers to detect cervical neoplasia.
Gynecologic oncology 2007;107(3):549-53.
2007: Makoto Suzuki; Hisayuki Shigematsu; Takahiro Nakajima; Rieko Kubo; Shinichiro Motohashi; Yasuo Sekine; Kiyoshi Shibuya; Toshihiko Iizasa; Kenzo Hiroshima; Yukio Nakatani; Adi F Gazdar; Takehiko Fujisawa
Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(20):6087-92.
2007: Shinichi Toyooka; Keitaro Matsuo; Hisayuki Shigematsu; Takayuki Kosaka; Masaki Tokumo; Yasushi Yatabe; Shuji Ichihara; Michio Inukai; Hiroshi Suehisa; Junichi Soh; Katsuyuki Kiura; Kwun M Fong; Huei Lee; Ignacio I Wistuba; Adi F Gazdar; Tetsuya Mitsudomi; Hiroshi Date
The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5763-8.
2007: Sophie Sun; Joan H Schiller; Adi F Gazdar
Lung cancer in never smokers--a different disease.
Nature reviews. Cancer 2007;7(10):778-90.
2007: Timothy C Kennedy; Annette McWilliams; Eric Edell; Tom G Sutedja; Gordon Downie; Rex C-W Yung; Adi F Gazdar; Praveen N Mathur
Bronchial intraepithelial neoplasia/early central airways lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition).
Chest 2007;132(3 Suppl):221S-233S.
2007: Yuanbin Chen; Melissa A De Marco; Irene Graziani; Adi F Gazdar; Peter R Strack; Lucio Miele; Maurizio Bocchetta
Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung.
Cancer research 2007;67(17):7954-9.
2007: David Padrón; Mitsuo Sato; Jerry W Shay; Adi F Gazdar; John D Minna; Michael Roth
Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized.
Cancer research 2007;67(16):7695-702.
2007: David Shames; John D Minna; Adi F Gazdar
Methods for detecting DNA methylation in tumors: from bench to bedside.
Cancer letters 2007;251(2):187-98.
2007: Haris G Vikis; Mitsuo Sato; Michael James; Daolong Wang; Yian Wang; Min Wang; Dongmei Jia; Yan Liu; Joan E Bailey-Wilson; Christopher I Amos; Susan Pinney; Gloria M Petersen; Mariza de Andrade; Ping Yang; Jonathan S Wiest; Pamela R Fain; Ann Grossbart Schwartz; Adi F Gazdar; Colette Gaba; Henry Rothschild; Diptasri Mandal; Elena Kupert; Daniela Seminara; Avinash Viswanathan; Ramaswamy Govindan; John D Minna; Marshall W Anderson; Ming You
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity.
Cancer research 2007;67(10):4665-70.
2007: D C L Lam; Luc Girard; Ruben Ramirez; Wing-Shun Chau; Wai Sing Suen; Shelley Sheridan; Vicky P C Tin; Lap-Ping Chung; Maria P Wong; Jerry W Shay; Adi F Gazdar; Wah K Lam; John D Minna
Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers.
Cancer research 2007;67(10):4638-47.
2007: Darryl L Carter; Madeline Vazquez; Douglas B Flieder; Elizabeth Brambilla; Adi F Gazdar; Masayuki Noguchi; William D Travis; Arin Kramer; Rowena Yip; David F Yankelevitz; Claudia I Henschke
Comparison of pathologic findings of baseline and annual repeat cancers diagnosed on CT screening.
Lung cancer (Amsterdam, Netherlands) 2007;56(2):193-9.
2007: Masaharu Nomura; Hisayuki Shigematsu; Lin Li; Makoto Suzuki; Takao Takahashi; Pila Estess; Mark Siegelman; Ziding Feng; Harubumi Kato; Antonio Marchetti; Jerry W Shay; Margaret R Spitz; Ignacio I Wistuba; John D Minna; Adi F Gazdar
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.
PLoS medicine 2007;4(4):e125.
2007: Mitsuo Sato; David Shames; Adi F Gazdar; John D Minna
A translational view of the molecular pathogenesis of lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2007;2(4):327-43.
2007: Fred R Hirsch; Marileila Varella-Garcia; Federico Cappuzzo; Jason McCoy; Lynne Bemis; A C Xavier; Rafal Dziadziuszko; Paul H Gumerlock; Kari Chansky; Howard L West; Adi F Gazdar; Lucio Crino; David R Gandara; Wilbur A Franklin; Paul A Bunn
Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(4):752-60.
2007: Makoto Suzuki; Hisayuki Shigematsu; David Shames; noriaki sunaga; Takao Takahashi; Narayan Shivapurkar; Toshihiko Iizasa; John D Minna; Takehiko Fujisawa; Adi F Gazdar
Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers.
Annals of surgical oncology 2007;14(4):1397-404.
2007: Narayan Shivapurkar; Victor Stastny; Makoto Suzuki; Ignacio I Wistuba; Lin Li; Yingye Zheng; Ziding Feng; Bernard Hol; Clemens F M Prinsen; Frederik B J M Thunnissen; Adi F Gazdar
Application of a methylation gene panel by quantitative PCR for lung cancers.
Cancer letters 2007;247(1):56-71.
2007: Adi F Gazdar
DNA repair and survival in lung cancer--the two faces of Janus.
The New England journal of medicine 2007;356(8):771-3.
2007: Adi F Gazdar; Michael J Thun
Lung cancer, smoke exposure, and sex.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(5):469-71.
2007: David Shames; John D Minna; Adi F Gazdar
DNA methylation in health, disease, and cancer.
Current molecular medicine 2007;7(1):85-102.
2007: Ubaradka G Sathyanarayana; Angela Yen Moore; Lin Li; Asha Padar; Kuntal Majmudar; Victor Stastny; Prakash Makarla; Makoto Suzuki; John D Minna; Ziding Feng; Adi F Gazdar
Sun exposure related methylation in malignant and non-malignant skin lesions.
Cancer letters 2007;245(1-2):112-20.
2007: Min Wang; Haris G Vikis; Yian Wang; Dongmei Jia; Daolong Wang; Laura J Bierut; Joan E Bailey-Wilson; Christopher I Amos; Susan Pinney; Gloria M Petersen; Mariza de Andrade; Ping Yang; Jonathan S Wiest; Pamela R Fain; Ann Grossbart Schwartz; Adi F Gazdar; John D Minna; Colette Gaba; Henry Rothschild; Diptasri Mandal; Elena Kupert; Daniela Seminara; Yan Liu; Avinash Viswanathan; Ramaswamy Govindan; Marshall W Anderson; Ming You
Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1.
Cancer research 2007;67(1):93-9.
2006: David Shames; Luc Girard; Boning Gao; Mitsuo Sato; Cheryl M Lewis; Narayan Shivapurkar; Aixiang Jiang; Charles M Perou; Young H Kim; Jonathan R Pollack; Kwun M Fong; Chi-Leung Lam; Maria Wong; Yu Shyr; Rita Nanda; Olufunmilayo I Olopade; William Gerald; David M Euhus; Jerry W Shay; Adi F Gazdar; John D Minna
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies.
PLoS medicine 2006;3(12):e486.
2006: Richard M Neve; Koei Chin; Jane Fridlyand; Jennifer Yeh; Frederick L Baehner; Tea Fevr; Laura Clark; Nora Bayani; Jean-Philippe Coppe; Frances Tong; Terence P Speed; Paul Spellman; Sandy Devries; Anna Lapuk; Nick J Wang; Wen-Lin Kuo; Jackie L Stilwell; Daniel Pinkel; Donna G Albertson; Frederic M Waldman; Frank McCormick; Robert B Dickson; Michael D Johnson; Marc Lippman; Stephen Ethier; Adi F Gazdar; Joe Gray
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer cell 2006;10(6):515-27.
2006: Barbara Helfrich; David Raben; Marileila Varella-Garcia; Dan Gustafson; Daniel C Chan; Lynne Bemis; Chris Coldren; Anna E Barón; Chan Zeng; Wilbur A Franklin; Fred R Hirsch; Adi F Gazdar; John D Minna; Paul A Bunn
Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(23):7117-25.
2006: Makoto Suzuki; Hisayuki Shigematsu; Narayan Shivapurkar; Jyotsna Reddy; Kuniharu Miyajima; Takao Takahashi; Adi F Gazdar; Eugene P Frenkel
Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer.
Cancer letters 2006;242(2):222-30.
2006: Tobias Sjöblom; Siân Jones; Laura D Wood; DONALD PARSONS; Jimmy Lin; Thomas D Barber; Diana Mandelker; Rebecca J Leary; Janine Ptak; Natalie Silliman; Stephen Szabo; Phillip Buckhaults; Christopher Farrell; Paul Meeh; Sanford D Markowitz; Joseph Willis; Dawn Dawson; James Willson; Adi F Gazdar; James Hartigan; Leo Wu; Changsheng Liu; Giovanni Parmigiani; Ben Ho Park; Kurtis E Bachman; Nickolas Papadopoulos; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu
The consensus coding sequences of human breast and colorectal cancers.
Science (New York, N.Y.) 2006;314(5797):268-74.
2006: Amit K Das; Mitsuo Sato; Michael D Story; Michael Peyton; Robert Graves; Stella Redpath; Luc Girard; Adi F Gazdar; Jerry W Shay; John D Minna; Chaitanya S Nirodi
Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation.
Cancer research 2006;66(19):9601-8.
2006: Laura D Wood; Eric S Calhoun; Natalie Silliman; Janine Ptak; Stephen Szabo; Steve M Powell; Gregory J Riggins; Tian-Li Wang; Hai Yan; Adi F Gazdar; Scott E Kern; Len Pennacchio; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
Human mutation 2006;27(10):1060-1.
2006: Bin-Bing S Zhou; Michael Peyton; Biao He; Changnian Liu; Luc Girard; Eian Caudler; Yvonne Lo; Frédéric Baribaud; Iwao Mikami; Noemi Reguart; Gengjie Yang; Yanlong Li; Wenqing Yao; Kris Vaddi; Adi F Gazdar; Steven M Friedman; David M Jablons; Robert C Newton; Jordan S Fridman; John D Minna; Peggy A Scherle
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.
Cancer cell 2006;10(1):39-50.
2006: Shizhen Emily Wang; Archana Narasanna; Marianela Perez-Torres; Bin Xiang; Frederick Y Wu; seungchan yang; Graham Carpenter; Adi F Gazdar; Senthil K Muthuswamy; Carlos L Arteaga
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
Cancer cell 2006;10(1):25-38.
2006: Bradley P Coe; William W Lockwood; Luc Girard; Raj Chari; Calum MacAulay; Stephen Lam; Adi F Gazdar; John D Minna; Wan L Lam
Differential disruption of cell cycle pathways in small cell and non-small cell lung cancer.
British journal of cancer 2006;94(12):1927-35.
2006: Makoto Suzuki; Hisayuki Shigematsu; Toshihiko Iizasa; Kenzo Hiroshima; Yukio Nakatani; John D Minna; Adi F Gazdar; Takehiko Fujisawa
Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer.
Cancer 2006;106(10):2200-7.
2006: Douglas B Flieder; Madeline Vazquez; Darryl L Carter; Elizabeth Brambilla; Adi F Gazdar; Masayuki Noguchi; William D Travis; Arin Kramer; David F Yankelevitz; Claudia I Henschke
Pathologic findings of lung tumors diagnosed on baseline CT screening.
The American journal of surgical pathology 2006;30(5):606-13.
2006: Keisuke Aoe; Akio Hiraki; Tomoyuki Murakami; Shinichi Toyooka; Narayan Shivapurkar; Adi F Gazdar; Naoko Sueoka; Koji Taguchi; Toshiaki Kamei; Hiroyasu Takeyama; Kazuro Sugi; Takumi Kishimoto
Infrequent existence of simian virus 40 large T antigen DNA in malignant mesothelioma in Japan.
Cancer science 2006;97(4):292-5.
2006: Cathie Garnis; William W Lockwood; Emily Vucic; Yong Ge; Luc Girard; John D Minna; Adi F Gazdar; Stephen Lam; Calum MacAulay; Wan L Lam
High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.
International journal of cancer. Journal international du cancer 2006;118(6):1556-64.
2006: Anne S Tsao; Xi Ming Tang; Bradley Sabloff; Lianchun Xiao; Hisayuki Shigematsu; Jack Roth; Margaret Spitz; Waun Ki Hong; Adi F Gazdar; Ignacio I Wistuba
Clinicopathologic characteristics of the EGFR gene mutation in non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(3):231-9.
2006: Issan Yee San Tam; Lap-Ping Chung; Wai Sing Suen; Elaine Wang; May C M Wong; Kok Keung Ho; Wah K Lam; Shui-Wah Chiu; Luc Girard; John D Minna; Adi F Gazdar; Maria P Wong
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1647-53.
2006: Mitsuo Sato; Melville B Vaughan; Luc Girard; Michael Peyton; Woochang Lee; David Shames; Ruben D Ramirez; noriaki sunaga; Adi F Gazdar; Jerry W Shay; John D Minna
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.
Cancer research 2006;66(4):2116-28.
2006: Takao Takahashi; Hisayuki Shigematsu; Narayan Shivapurkar; Jyotsna Reddy; Yingye Zheng; Ziding Feng; Makoto Suzuki; Masaharu Nomura; Meena Augustus; Jing Yin; Meltzer Stephen J.; Adi F Gazdar
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.
International journal of cancer. Journal international du cancer 2006;118(4):924-31.
2006: Gerwin Heller; Kwun M Fong; Luc Girard; Sonja Seidl; Adelheid End-Pfützenreuter; György Lang; Adi F Gazdar; John D Minna; Christoph C Zielinski; Sabine Zöchbauer-Müller
Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas.
Oncogene 2006;25(6):959-68.
2006: Shinichi Toyooka; Masaki Tokumo; Hisayuki Shigematsu; Keitaro Matsuo; Hiroaki Asano; Kunitoshi Tomii; Shuji Ichihara; Makoto Suzuki; Motoi Aoe; Hiroshi Date; Adi F Gazdar; Nobuyoshi Shimizu
Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.
Cancer research 2006;66(3):1371-5.
2006: Mi-Sook Kim; Joon Jeong; Tadeusz Majewski; Andrzej Kram; Dong-Sup Yoon; Ruo-Dan Zhang; Jun-Zhi Li; Konrad Ptaszynski; Tang C Kuang; Jain-Hua Zhou; Ubaradka G Sathyanarayana; Tomasz Tuziak; Dennis A Johnston; H Barton Grossman; Adi F Gazdar; Steven E Scherer; William F Benedict; Bogdan Czerniak
Evidence for alternative candidate genes near RB1 involved in clonal expansion of in situ urothelial neoplasia.
Laboratory investigation; a journal of technical methods and pathology 2006;86(2):175-90.
2006: Samir E Witta; Robert M Gemmill; Fred R Hirsch; Christopher Coldren; Karla Hedman; Larisa Ravdel; Barbara Helfrich; Rafal Dziadziuszko; Daniel C Chan; Michio Sugita; Zeng Chan; Anna Baron; Wilbur Franklin; Harry A Drabkin; Luc Girard; Adi F Gazdar; John D Minna; Paul A Bunn
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.
Cancer research 2006;66(2):944-50.
2006: Hisayuki Shigematsu; Adi F Gazdar
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers.
International journal of cancer. Journal international du cancer 2006;118(2):257-62.
2006: Ignacio I Wistuba; Adi F Gazdar
Lung cancer preneoplasia.
Annual review of pathology 2006;1():331-48.
2006: Adi F Gazdar
Rapid screening for EGFR mutations: pros and cons.
Cancer journal (Sudbury, Mass.) 2006;12(1):17-8.
2006: Bradley P Coe; Eric H L Lee; Bryan Chi; Luc Girard; John D Minna; Adi F Gazdar; Stephen Lam; Calum MacAulay; Wan L Lam
Gain of a region on 7p22.3, containing MAD1L1, is the most frequent event in small-cell lung cancer cell lines.
Genes, chromosomes & cancer 2006;45(1):11-9.
2005: Adi F Gazdar; John D Minna
Inhibition of EGFR signaling: all mutations are not created equal.
PLoS medicine 2005;2(11):e377.
2005: Makoto Suzuki; Hisayuki Shigematsu; David Shames; noriaki sunaga; T Takahashi; Narayan Shivapurkar; Toshihiko Iizasa; Eugene P Frenkel; John D Minna; Takehiko Fujisawa; Adi F Gazdar
DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers.
British journal of cancer 2005;93(9):1029-37.
2005: Makoto Suzuki; Hisayuki Shigematsu; Kenzo Hiroshima; Toshihiko Iizasa; Yukio Nakatani; John D Minna; Adi F Gazdar; Takehiko Fujisawa
Epidermal growth factor receptor expression status in lung cancer correlates with its mutation.
Human pathology 2005;36(10):1127-34.
2005: Anirban Maitra; Dan E Arking; Narayan Shivapurkar; Morna Ikeda; Victor Stastny; Keyaunoosh Kassauei; Guoping Sui; David J Cutler; Ying Liu; Sandii N Brimble; Karin Noaksson; Johan Hyllner; Thomas C Schulz; Xianmin Zeng; William J Freed; Jeremy Crook; Suman Abraham; Alan Colman; Peter Sartipy; Sei-Ichi Matsui; Melissa Carpenter; Adi F Gazdar; Mahendra S Rao; Aravinda Chakravarti
Genomic alterations in cultured human embryonic stem cells.
Nature genetics 2005;37(10):1099-103.
2005: Sabine Zöchbauer-Müller; Kwun M Fong; Joseph Geradts; Xie Xu; Sonja Seidl; Adelheid End-Pfützenreuter; György Lang; Gerwin Heller; Christoph C Zielinski; Adi F Gazdar; John D Minna
Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation.
Oncogene 2005;24(41):6249-55.
2005: Narayan Shivapurkar; Victor Stastny; Takao Takahashi; Makoto Suzuki; Chinyere Echebiri; Jyotsna Reddy; Adi F Gazdar
Novel real-time PCR assay using a universal molecular marker for diagnosis of hematologic cancers.
International journal of cancer. Journal international du cancer 2005;116(4):656-60.
2005: Ximing Tang; Hisayuki Shigematsu; B Nebiyou Bekele; Jack A Roth; John D Minna; Waun Ki Hong; Adi F Gazdar; Ignacio I Wistuba
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients.
Cancer research 2005;65(17):7568-72.
2005: John D Minna; Michael Peyton; Adi F Gazdar
Gefitinib versus cetuximab in lung cancer: round one.
Journal of the National Cancer Institute 2005;97(16):1168-9.
2005: Prakash Makarla; M Hossein Saboorian; Raheela Ashfaq; Kiyomi O Toyooka; Shinichi Toyooka; John D Minna; Adi F Gazdar; John O Schorge
Promoter hypermethylation profile of ovarian epithelial neoplasms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5365-9.
2005: Federico Cappuzzo; Marileila Varella-Garcia; Hisayuki Shigematsu; Irene Domenichini; Stefania Bartolini; Giovanni Luca Ceresoli; Elisa Rossi; Vienna Ludovini; Vanesa Gregorc; Luca Toschi; Wilbur A Franklin; Lucio Crino; Adi F Gazdar; Paul A Bunn; Fred R Hirsch
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(22):5007-18.
2005: Mauricio Moreno; Fernando Pimentel; Adi F Gazdar; Ignacio I Wistuba; Juan Miquel
TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma.
Annals of hepatology 2005;4(3):192-9.
2005: Takao Takahashi; Makoto Suzuki; Hisayuki Shigematsu; Narayan Shivapurkar; Chinyere Echebiri; Masaharu Nomura; Victor Stastny; Meena Augustus; Cheng-Wen Wu; Ignacio I Wistuba; Meltzer Stephen J.; Adi F Gazdar
Aberrant methylation of Reprimo in human malignancies.
International journal of cancer. Journal international du cancer 2005;115(4):503-10.
2005: Laura-Jane Henderson; Bradley P Coe; E H L Lee; Luc Girard; Adi F Gazdar; John D Minna; Stephen Lam; Calum MacAulay; Wan L Lam
Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small-cell lung carcinoma cells.
British journal of cancer 2005;92(8):1553-60.
2005: Ikuo Sekine; Mitsuo Sato; noriaki sunaga; Shinichi Toyooka; Michael Peyton; Ramon Parsons; Weidong Wang; Adi F Gazdar; John D Minna
The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer.
Oncogene 2005;24(16):2735-8.
2005: José I López; Thomas V Colby; Adi F Gazdar
Current status of small peripheral adenocarcinomas of the lung and their importance to pathologists.
Annals of diagnostic pathology 2005;9(2):115-22.
2005: John Jakob; Satoru Nagase; Adi F Gazdar; Minchen Chien; Irina Morozova; James J Russo; Subhadra V Nandula; Vundavalli Murty; Chi-Ming Li; Benjamin Tycko; Ramon Parsons
Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line.
Genes, chromosomes & cancer 2005;42(4):372-83.
2005: Hideaki Dote; Shinichi Toyooka; Kazunori Tsukuda; Masaaki Yano; T Ota; M Murakami; M Naito; M Toyota; Adi F Gazdar; Nobuyoshi Shimizu
Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour.
British journal of cancer 2005;92(6):1117-25.
2005: Makoto Suzuki; C Hao; T Takahashi; Hisayuki Shigematsu; Narayan Shivapurkar; Ubaradka G Sathyanarayana; Toshihiko Iizasa; Takehiko Fujisawa; K Hiroshima; Adi F Gazdar
Aberrant methylation of SPARC in human lung cancers.
British journal of cancer 2005;92(5):942-8.
2005: Hisayuki Shigematsu; Li Lin; Takao Takahashi; Masaharu Nomura; Makoto Suzuki; Ignacio I Wistuba; Kwun M Fong; Huei Lee; Shinichi Toyooka; Nobuyoshi Shimizu; Takehiko Fujisawa; Ziding Feng; Jack A Roth; Joachim Herz; John D Minna; Adi F Gazdar
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
Journal of the National Cancer Institute 2005;97(5):339-46.
2005: Hisayuki Shigematsu; Takao Takahashi; Masaharu Nomura; Kuntal Majmudar; Makoto Suzuki; Huei Lee; Ignacio I Wistuba; Kwun M Fong; Shinichi Toyooka; Nobuyoshi Shimizu; Takehiko Fujisawa; John D Minna; Adi F Gazdar
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.
Cancer research 2005;65(5):1642-6.
2005: Makoto Suzuki; Hisayuki Shigematsu; Takao Takahashi; Narayan Shivapurkar; Ubaradka G Sathyanarayana; Toshihiko Iizasa; Takehiko Fujisawa; Adi F Gazdar
Aberrant methylation of Reprimo in lung cancer.
Lung cancer (Amsterdam, Netherlands) 2005;47(3):309-14.
2005: Bradley P Coe; Laura-Jane Henderson; Cathie Garnis; Ming Tsao; Adi F Gazdar; John D Minna; Stephen Lam; Calum MacAulay; Wan L Lam
High-resolution chromosome arm 5p array CGH analysis of small cell lung carcinoma cell lines.
Genes, chromosomes & cancer 2005;42(3):308-13.
2005: Makoto Suzuki; Shinichi Toyooka; Narayan Shivapurkar; Hisayuki Shigematsu; Kuniharu Miyajima; Takao Takahashi; Victor Stastny; Andrea L Zern; Takehiko Fujisawa; Harvey I Pass; Michele Carbone; Adi F Gazdar
Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection.
Oncogene 2005;24(7):1302-8.
2005: Hisayuki Shigematsu; Makoto Suzuki; Takao Takahashi; Kuniharu Miyajima; Shinichi Toyooka; Narayan Shivapurkar; Gail Tomlinson; Domenico Mastrangelo; Harvey I Pass; Elizabeth Brambilla; Ubaradka G Sathyanarayana; Bogdan Czerniak; Takehiko Fujisawa; Nobuyoshi Shimizu; Adi F Gazdar
Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies.
International journal of cancer. Journal international du cancer 2005;113(4):600-4.
2005: Masaki Tokumo; Shinichi Toyooka; Katsuyuki Kiura; Hisayuki Shigematsu; Kunitoshi Tomii; Motoi Aoe; Kouichi Ichimura; Toshihide Tsuda; Masaaki Yano; Kazunori Tsukuda; Masahiro Tabata; Hiroshi Ueoka; Mitsune Tanimoto; Hiroshi Date; Adi F Gazdar; Nobuyoshi Shimizu
The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1167-73.
2005: Jyotsna Reddy; Narayan Shivapurkar; Takao Takahashi; Gunjan Parikh; Victor Stastny; Chinyere Echebiri; Katherine Crumrine; Sabine Zöchbauer-Müller; Johannes Drach; Yingye Zheng; Ziding Feng; Steven H Kroft; Robert W McKenna; Adi F Gazdar
Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors.
Oncogene 2005;24(4):732-6.
2005: Joseph M Amann; Shailaja Kalyankrishna; Pierre P Massion; Joyce E Ohm; Luc Girard; Hisayuki Shigematsu; Michael Peyton; Denise M Juroske; Yuhui Huang; J Stuart Salmon; Young H Kim; Jonathan R Pollack; Kiyoshi Yanagisawa; Adi F Gazdar; John D Minna; Jonathan M Kurie; Yuhui Huang
Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer.
Cancer research 2005;65(1):226-35.
2005: Martial Guillaud; Jean C Le Riche; Chris Dawe; Jagoda Korbelik; Andrew J Coldman; Ignacio I Wistuba; In-Won Park; Adi F Gazdar; Stephen Lam; Calum MacAulay
Nuclear morphometry as a biomarker for bronchial intraepithelial neoplasia: correlation with genetic damage and cancer development.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;63(1):34-40.
2005: Masaaki Yano; Shinichi Toyooka; Kazunori Tsukuda; Hideaki Dote; Mamoru Ouchida; Tetsuro Hanabata; Motoi Aoe; Hiroshi Date; Adi F Gazdar; Nobuyoshi Shimizu
Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers.
International journal of cancer. Journal international du cancer 2005;113(1):59-66.
2004: Ruben D Ramirez; Shelley Sheridan; Luc Girard; Mitsuo Sato; Young Kim; Jon Pollack; Michael Peyton; Ying Zou; Jonathan M Kurie; J Michael DiMaio; Sara Milchgrub; Alice L Smith; Rhonda F Souza; Laura Gilbey; Xi Zhang; Kenia Gandia; Melville B Vaughan; Woodring E Wright; Adi F Gazdar; Jerry W Shay; John D Minna
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins.
Cancer research 2004;64(24):9027-34.
2004: Hisayuki Shigematsu; Adi F Gazdar
Mutations of EGFR in lung cancers and their implications for targeted therapy.
Discovery medicine 2004;4(24):444-7.
2004: Stephen Lam; Jean C leRiche; Annette McWilliams; Calum MacAulay; Yulia Dyachkova; Eva Szabo; John Mayo; Robert Schellenberg; Andrew J Coldman; Ernest T Hawk; Adi F Gazdar
A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(19):6502-11.
2004: Adi F Gazdar; Hisayuki Shigematsu; Joachim Herz; John D Minna
Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?
Trends in molecular medicine 2004;10(10):481-6.
2004: Takao Takahashi; Narayan Shivapurkar; Erick Riquelme; Hisayuki Shigematsu; Jyotsna Reddy; Makoto Suzuki; Kuniharu Miyajima; Xian Zhou; B Nebiyou Bekele; Adi F Gazdar; Ignacio I Wistuba
Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 1):6126-33.
2004: Ignacio I Wistuba; Adi F Gazdar
Gallbladder cancer: lessons from a rare tumour.
Nature reviews. Cancer 2004;4(9):695-706.
2004: Joan E Bailey-Wilson; Christopher I Amos; Susan Pinney; Gloria M Petersen; Mariza de Andrade; Jonathan S Wiest; Pamela R Fain; Ann Grossbart Schwartz; Ming You; Wilbur Franklin; C Klein; Adi F Gazdar; Henry Rothschild; Diptasri Mandal; Teresa A Coons; Joshua P Slusser; J Lee; Colette Gaba; Elena Kupert; A Perez; X Zhou; D Zeng; Q Liu; Qing Zhang; Daniela Seminara; John D Minna; Marshall W Anderson
A major lung cancer susceptibility locus maps to chromosome 6q23-25.
American journal of human genetics 2004;75(3):460-74.
2004: S Toyooka; Makoto Suzuki; R Maruyama; K O Toyooka; K Tsukuda; Y Fukuyama; Toshihiko Iizasa; M Aoe; H Date; Takehiko Fujisawa; N Shimizu; Adi F Gazdar
The relationship between aberrant methylation and survival in non-small-cell lung cancers.
British journal of cancer 2004;91(4):771-4.
2004: Shinichi Toyooka; Makoto Suzuki; Toshihide Tsuda; Kiyomi O Toyooka; Riichiroh Maruyama; Kazunori Tsukuda; Yasuro Fukuyama; Toshihiko Iizasa; Takehiko Fujisawa; Nobuyoshi Shimizu; John D Minna; Adi F Gazdar
Dose effect of smoking on aberrant methylation in non-small cell lung cancers.
International journal of cancer. Journal international du cancer 2004;110(3):462-4.
2004: noriaki sunaga; Kuniharu Miyajima; Makoto Suzuki; Mitsuo Sato; Michael A White; Ruben D Ramirez; Jerry W Shay; Adi F Gazdar; John D Minna
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer.
Cancer research 2004;64(12):4277-85.
2004: John D Minna; Adi F Gazdar; Stephen R Sprang; Joachim Herz
Cancer. A bull's eye for targeted lung cancer therapy.
Science (New York, N.Y.) 2004;304(5676):1458-61.
2004: Narayan Shivapurkar; Takao Takahashi; Jyotsna Reddy; Yingye Zheng; Victor Stastny; Robert Collins; Shinichi Toyooka; Makato Suzuki; Gunjan Parikh; Sheryl L Asplund; Steven H Kroft; Charles F Timmons; Robert W McKenna; Ziding Feng; Adi F Gazdar
Presence of simian virus 40 DNA sequences in human lymphoid and hematopoietic malignancies and their relationship to aberrant promoter methylation of multiple genes.
Cancer research 2004;64(11):3757-60.
2004: Adi F Gazdar; Kuniharu Miyajima; Jyotsna Reddy; Ubaradka G Sathyanarayana; Hisayuki Shigematsu; Makoto Suzuki; Takao Takahashi; Narayan Shivapurkar
Molecular targets for cancer therapy and prevention.
Chest 2004;125(5 Suppl):97S-101S.
2004: Takao Takahashi; Narayan Shivapurkar; Jyotsna Reddy; Hisayuki Shigematsu; Kuniharu Miyajima; Makoto Suzuki; Shinichi Toyooka; Sabine Zöchbauer-Müller; Johannes Drach; Gunjan Parikh; Yingye Zheng; Ziding Feng; Steven H Kroft; Charles F Timmons; Robert W McKenna; Adi F Gazdar
DNA methylation profiles of lymphoid and hematopoietic malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):2928-35.
2004: Makoto Suzuki; noriaki sunaga; David Shames; Shinichi Toyooka; Adi F Gazdar; John D Minna
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
Cancer research 2004;64(9):3137-43.
2004: Narayan Shivapurkar; Shinichi Toyooka; Kiyomi O Toyooka; Jyotsna Reddy; Kuniharu Miyajima; Makoto Suzuki; Hisayuki Shigematsu; Takao Takahashi; Gunjan Parikh; Harvey I Pass; Preet M Chaudhary; Adi F Gazdar
Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.
International journal of cancer. Journal international du cancer 2004;109(5):786-92.
2004: Yardena Samuels; Zhenghe Wang; Alberto Bardelli; Natalie Silliman; Janine Ptak; Stephen Szabo; Hai Yan; Adi F Gazdar; Steven M Powell; Gregory J Riggins; James Willson; Sanford Markowitz; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
High frequency of mutations of the PIK3CA gene in human cancers.
Science (New York, N.Y.) 2004;304(5670):554.
2004: Riichiroh Maruyama; Kenji Sugio; Ichiro Yoshino; Yoshihiko Maehara; Adi F Gazdar
Hypermethylation of FHIT as a prognostic marker in nonsmall cell lung carcinoma.
Cancer 2004;100(7):1472-7.
2004: Hideaki Dote; Shinichi Toyooka; Kazunori Tsukuda; Masaaki Yano; Mamoru Ouchida; Hiroyoshi Doihara; Makoto Suzuki; Hong Chen; Jer-Tsong Hsieh; Adi F Gazdar; Nobuyoshi Shimizu
Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):2082-9.
2004: Ubaradka G Sathyanarayana; Riichiroh Maruyama; Asha Padar; Makoto Suzuki; Jolanta Bondaruk; Arthur I Sagalowsky; John D Minna; Eugene P Frenkel; H Barton Grossman; Bogdan Czerniak; Adi F Gazdar
Molecular detection of noninvasive and invasive bladder tumor tissues and exfoliated cells by aberrant promoter methylation of laminin-5 encoding genes.
Cancer research 2004;64(4):1425-30.
2003: Ubaradka G Sathyanarayana; Asha Padar; Makoto Suzuki; Riichiroh Maruyama; Hisayuki Shigematsu; Jer-Tsong Hsieh; Eugene P Frenkel; Adi F Gazdar
Aberrant promoter methylation of laminin-5-encoding genes in prostate cancers and its relationship to clinicopathological features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6395-400.
2003: Ubaradka G Sathyanarayana; Asha Padar; Chun Xian Huang; Makoto Suzuki; Hisayuki Shigematsu; B Nebiyou Bekele; Adi F Gazdar
Aberrant promoter methylation and silencing of laminin-5-encoding genes in breast carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6389-94.
2003: Stephen Lam; Xiaochun Xu; Helga Parker-Klein; Jean C Le Riche; Calum MacAulay; Martial Guillaud; Andrew J Coldman; Adi F Gazdar; Reuben Lotan
Surrogate end-point biomarker analysis in a retinol chemoprevention trial in current and former smokers with bronchial dysplasia.
International journal of oncology 2003;23(6):1607-13.
2003: Sabine Zöchbauer-Müller; Stephen Lam; Shinichi Toyooka; Arvind K Virmani; Kiyomi O Toyooka; Sonja Seidl; John D Minna; Adi F Gazdar
Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers.
International journal of cancer. Journal international du cancer 2003;107(4):612-6.
2003: Makoto Suzuki; Shinichi Toyooka; Kuniharu Miyajima; Toshihiko Iizasa; Takehiko Fujisawa; Nebiyou B Bekele; Adi F Gazdar
Alterations in the mitochondrial displacement loop in lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5636-41.
2003: Arvind K Virmani; Asha Rathi; Shashank Heda; Kenji Sugio; Cheryl Lewis; Vijay S Tonk; Takashi Takahashi; Jack A Roth; John D Minna; David M Euhus; Adi F Gazdar
Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers.
International journal of cancer. Journal international du cancer 2003;107(3):341-5.
2003: Adi F Gazdar; Michele Carbone
Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40.
Clinical lung cancer 2003;5(3):177-81.
2003: Asha Padar; Ubaradka G Sathyanarayana; Makoto Suzuki; Riichiroh Maruyama; Jer-Tsong Hsieh; Eugene P Frenkel; John D Minna; Adi F Gazdar
Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4730-4.
2003: Adi F Gazdar
Environmental tobacco smoke, carcinogenesis, and angiogenesis: a double whammy?
Cancer cell 2003;4(3):159-60.
2003: Asha Rathi; Arvind K Virmani; Kenichi Harada; Charles F Timmons; Kuniharu Miyajima; Robert J Hay; Domenico Mastrangelo; Anirban Maitra; Gail Tomlinson; Adi F Gazdar
Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3674-8.
2003: Ignacio I Wistuba; Carmen Behrens; Jorge Albores-Saavedra; Ruby Delgado; Francisco Lopez; Adi F Gazdar
Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3615-9.
2003: Arvind K Virmani; Asha Rathi; Kenji Sugio; Ubaradka G Sathyanarayana; Shinichi Toyooka; Frank C Kischel; Vijay S Tonk; Asha Padar; Takashi Takahashi; Jack A Roth; David M Euhus; John D Minna; Adi F Gazdar
Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer.
International journal of cancer. Journal international du cancer 2003;106(2):198-204.
2003: Michele Carbone; Maurizio Bocchetta; Alfonso Cristaudo; Salih Emri; Adi F Gazdar; Bharat Jasani; John A Lednicky; Lucio Miele; Luciano Mutti; Harvey I Pass; Marc Ramael; Paola Rizzo; Joseph R Testa; Sascha Weggen; Anthony Yeung
SV40 and human brain tumors.
International journal of cancer. Journal international du cancer 2003;106(1):140-2; author reply 143-5.
2003: Shinichi Toyooka; Kiyomi O Toyooka; Kuniharu Miyajima; Jyotsna L Reddy; Minoru Toyota; Ubaradka G Sathyanarayana; Asha Padar; Melvyn S Tockman; Stephen Lam; Narayan Shivapurkar; Adi F Gazdar
Epigenetic down-regulation of death-associated protein kinase in lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):3034-41.
2003: Ubaradka G Sathyanarayana; Shinichi Toyooka; Asha Padar; Takashi Takahashi; Elizabeth Brambilla; John D Minna; Adi F Gazdar
Epigenetic inactivation of laminin-5-encoding genes in lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2665-72.
2003: Narayan Shivapurkar; Jyotsna Reddy; Preet M Chaudhary; Adi F Gazdar
Apoptosis and lung cancer: a review.
Journal of cellular biochemistry 2003;88(5):885-98.
2003: Masahiro Sakaguchi; Arvind K Virmani; Marla W Dudak; George N Peters; A Marilyn Leitch; Hossein Saboorian; Adi F Gazdar; David M Euhus
Clinical relevance of reverse transcriptase-polymerase chain reaction for the detection of axillary lymph node metastases in breast cancer.
Annals of surgical oncology 2003;10(2):117-25.
2003: Shinichi Toyooka; Toshihide Tsuda; Adi F Gazdar
The TP53 gene, tobacco exposure, and lung cancer.
Human mutation 2003;21(3):229-39.
2003: Hong Chen; Shinichi Toyooka; Adi F Gazdar; Jer-Tsong Hsieh
Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines.
The Journal of biological chemistry 2003;278(5):3121-30.
2003: Shinichi Toyooka; Riichiroh Maruyama; Kiyomi O Toyooka; Dale McLerran; Ziding Feng; Yasuro Fukuyama; Arvind K Virmani; Sabine Zochbauer-Muller; Kazunori Tsukuda; Kenji Sugio; Nobuyoshi Shimizu; Kenji Shimizu; Huei Lee; Chih-Yi Chen; Kwun M Fong; Michael Z Gilcrease; Jack A Roth; John D Minna; Adi F Gazdar
Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer.
International journal of cancer. Journal international du cancer 2003;103(2):153-60.
2003: Stephen Lam; Calum MacAulay; Jean C leRiche; Adi F Gazdar
Key issues in lung cancer chemoprevention trials of new agents.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;163():182-95; discussion 264-6.
2003: Arvind K Virmani; Adi F Gazdar
Tumor suppressor genes in lung cancer.
Methods in molecular biology (Clifton, N.J.) 2003;222():97-115.
2003: Paul G Corn; Matthew K Summers; Franz Fogt; Arvind K Virmani; Adi F Gazdar; Thanos D Halazonetis; Wafik S El-Deiry
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
Carcinogenesis 2003;24(1):47-51.
2003: Ignacio I Wistuba; Adi F Gazdar
Characteristic genetic alterations in lung cancer.
Methods in molecular medicine 2003;74():3-28.
2002: Narayan Shivapurkar; Jyotsna Reddy; Hittu Matta; Ubaradka G Sathyanarayana; Chun Xian Huang; Shinichi Toyooka; John D Minna; Preet M Chaudhary; Adi F Gazdar
Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification.
Oncogene 2002;21(55):8510-4.
2002: Fumiaki Sato; David Shibata; Noam Harpaz; Yan Xu; Jing Yin; Yuriko Mori; Suna Wang; Andreea Olaru; Elena Deacu; Florin Selaru; Martha C Kimos; Prodromos Hytiroglou; Joanne Young; Barbara A Leggett; Adi F Gazdar; Shinichi Toyooka; John M Abraham; Meltzer Stephen J.
Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma.
Cancer research 2002;62(23):6820-2.
2002: Adi F Gazdar; Janet S Butel; Michele Carbone
SV40 and human tumours: myth, association or causality?
Nature reviews. Cancer 2002;2(12):957-64.
2002: Hittu Matta; Michael T Eby; Adi F Gazdar; Preet M Chaudhary
Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis.
Cancer biology & therapy 2002;1(6):652-60.
2002: Asha Rathi; Arvind K Virmani; John O Schorge; Keren J Elias; Riichiroh Maruyama; John D Minna; Samuel C Mok; Luc Girard; David A Fishman; Adi F Gazdar
Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3324-31.
2002: Ignacio I Wistuba; Li Mao; Adi F Gazdar
Smoking molecular damage in bronchial epithelium.
Oncogene 2002;21(48):7298-306.
2002: Kenichi Harada; Shinichi Toyooka; Narayan Shivapurkar; Anirban Maitra; Jyotsna L Reddy; Hittu Matta; Kuniharu Miyajima; Charles F Timmons; Gail Tomlinson; Domenico Mastrangelo; Robert J Hay; Preet M Chaudhary; Adi F Gazdar
Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines.
Cancer research 2002;62(20):5897-901.
2002: Annette McWilliams; Calum MacAulay; Adi F Gazdar; Stephen Lam
Innovative molecular and imaging approaches for the detection of lung cancer and its precursor lesions.
Oncogene 2002;21(45):6949-59.
2002: Ignacio I Wistuba; Anirban Maitra; R Carrasco; Moying Tang; P Troncoso; J D Minna; Adi F Gazdar
High resolution chromosome 3p, 8p, 9q and 22q allelotyping analysis in the pathogenesis of gallbladder carcinoma.
British journal of cancer 2002;87(4):432-40.
2002: Kiyomi O Toyooka; Shinichi Toyooka; Anirban Maitra; Qinghua Feng; Nancy C Kiviat; Alice Smith; John D Minna; Raheela Ashfaq; Adi F Gazdar
Establishment and validation of real-time polymerase chain reaction method for CDH1 promoter methylation.
The American journal of pathology 2002;161(2):629-34.
2002: Young-Ah Suh; Ho-Young Lee; Arvind Virmani; Jiemin Wong; Koren K Mann; Wilson H Miller; Adi F Gazdar; Jonathan M Kurie
Loss of retinoic acid receptor beta gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines.
Cancer research 2002;62(14):3945-9.
2002: Stephen Lam; Calum MacAulay; Jean C Le Riche; Yulia Dyachkova; Andrew J Coldman; Martial Guillaud; Ernest T Hawk; Marie-Odile Christen; Adi F Gazdar
A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia.
Journal of the National Cancer Institute 2002;94(13):1001-9.
2002: Shinichi Toyooka; Yasuro Fukuyama; Ignacio I Wistuba; Melvyn S Tockman; John D Minna; Adi F Gazdar
Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2292-7.
2002: Kenichi Harada; Shinichi Toyooka; Anirban Maitra; Riichiroh Maruyama; Kiyomi O Toyooka; Charles F Timmons; Gail Tomlinson; Domenico Mastrangelo; Robert J Hay; John D Minna; Adi F Gazdar
Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines.
Oncogene 2002;21(27):4345-9.
2002: Shinichi Toyooka; Michele Carbone; Kiyomi O Toyooka; Maurizio Bocchetta; Narayan Shivapurkar; John D Minna; Adi F Gazdar
Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells.
Oncogene 2002;21(27):4340-4.
2002: Shinichi Toyooka; Kiyomi O Toyooka; Kenichi Harada; Kuniharu Miyajima; Prakash Makarla; Ubaradka G Sathyanarayana; Jing Yin; Fumiaki Sato; Narayan Shivapurkar; Meltzer Stephen J.; Adi F Gazdar
Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas.
Cancer research 2002;62(12):3382-6.
2002: David M Euhus; Leslie Cler; Narayan Shivapurkar; Sara Milchgrub; George N Peters; A Marilyn Leitch; Shashank Heda; Adi F Gazdar
Loss of heterozygosity in benign breast epithelium in relation to breast cancer risk.
Journal of the National Cancer Institute 2002;94(11):858-60.
2002: Ignacio I Wistuba; Raheela Ashfaq; Anirban Maitra; Hector Alvarez; Erick Riquelme; Adi F Gazdar
Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma.
The American journal of pathology 2002;160(6):2073-9.
2002: John D Minna; Kwun Fong; Sabine Zöchbauer-Müller; Adi F Gazdar
Molecular pathogenesis of lung cancer and potential translational applications.
Cancer journal (Sudbury, Mass.) 2002;8 Suppl 1():S41-6.
2002: Jiaoti Huang; Carmen Behrens; Ignacio I Wistuba; Adi F Gazdar; Jaishree Jagirdar
Clonality of combined tumors.
Archives of pathology & laboratory medicine 2002;126(4):437-41.
2002: Narayan Shivapurkar; Kenichi Harada; Jyotsna Reddy; Richard Scheuermann; Yin Xu; Robert W McKenna; Sara Milchgrub; Steven H Kroft; Ziding Feng; Adi F Gazdar
Presence of simian virus 40 DNA sequences in human lymphomas.
Lancet 2002;359(9309):851-2.
2002: Arvind K Virmani; Jeffrey A Tsou; Kimberly D Siegmund; Linda Y C Shen; Tiffany I Long; Peter W Laird; Adi F Gazdar; Ite A Laird-Offringa
Hierarchical clustering of lung cancer cell lines using DNA methylation markers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(3):291-7.
2002: John D Minna; Jack A Roth; Adi F Gazdar
Focus on lung cancer.
Cancer cell 2002;1(1):49-52.
2002: Anirban Maitra; Adi F Gazdar; Todd O Moore; Angela Yen Moore
Loss of heterozygosity analysis of cutaneous melanoma and benign melanocytic nevi: laser capture microdissection demonstrates clonal genetic changes in acquired nevocellular nevi.
Human pathology 2002;33(2):191-7.
2002: Riichiroh Maruyama; Shinichi Toyooka; Kiyomi O Toyooka; Arvind K Virmani; Sabine Zöchbauer-Müller; Alfredo J Farinas; John D Minna; John McConnell; Eugene P Frenkel; Adi F Gazdar
Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):514-9.
2002: Joyce A O'Shaughnessy; Gary J Kelloff; Gary B Gordon; Andrew J Dannenberg; Waun Ki Hong; Carol J Fabian; Caroline C Sigman; Monica M Bertagnolli; Steven P Stratton; Stephen Lam; William G Nelson; Frank L Meyskens; David S Alberts; Michele Follen; Anil K Rustgi; Vassiliki A Papadimitrakopoulou; Peter T Scardino; Adi F Gazdar; Lee W Wattenberg; Michael B. Sporn; Wael A Sakr; Scott M Lippman; Daniel Von Hoff
Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):314-46.
2002: Sabine Zöchbauer-Müller; John D Minna; Adi F Gazdar
Aberrant DNA methylation in lung cancer: biological and clinical implications.
The oncologist 2002;7(5):451-7.
2002: Narayan Shivapurkar; Shinichi Toyooka; Michael T Eby; Chun Xian Huang; Ubaradka G Sathyanarayana; H Thomas Cunningham; Jyotsna L Reddy; Elizabeth Brambilla; Takashi Takahashi; John D Minna; Preet M Chaudhary; Adi F Gazdar
Differential inactivation of caspase-8 in lung cancers.
Cancer biology & therapy 2002;1(1):65-9.
2002: Sabine Zochbauer-Muller; Adi F Gazdar; John D Minna
Molecular pathogenesis of lung cancer.
Annual review of physiology 2002;64():681-708.
2001: Riichiroh Maruyama; Shinichi Toyooka; Kiyomi O Toyooka; Kenichi Harada; Arvind K Virmani; Sabine Zöchbauer-Müller; Alfredo J Farinas; Funda Vakar-Lopez; John D Minna; Arthur I Sagalowsky; Bogdan Czerniak; Adi F Gazdar
Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features.
Cancer research 2001;61(24):8659-63.
2001: Y Tomizawa; Yoshitaka Sekido; Masashi Kondo; Boning Gao; J Yokota; Joelle Roche; Harry A Drabkin; Michael I Lerman; Adi F Gazdar; John D Minna
Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13954-9.
2001: N Miura; N Onuki; Asha Rathi; Arvind K Virmani; S Nakamoto; Y Kishimoto; Y Murawaki; H Kawasaki; J Hasegawa; M Oshimura; William D Travis; Adi F Gazdar
hTR repressor-related gene on human chromosome 10p15.1.
British journal of cancer 2001;85(10):1510-4.
2001: Shinichi Toyooka; Kiyomi O Toyooka; Riichiroh Maruyama; Arvind K Virmani; Luc Girard; Kuniharu Miyajima; Kenichi Harada; Y Ariyoshi; Takashi Takahashi; Kenji Sugio; Elizabeth Brambilla; Michael Z Gilcrease; John D Minna; Adi F Gazdar
DNA methylation profiles of lung tumors.
Molecular cancer therapeutics 2001;1(1):61-7.
2001: X L Xu; L C Wu; F Du; A Davis; Michael Peyton; Y Tomizawa; Anirban Maitra; Gail Tomlinson; Adi F Gazdar; Bernard E Weissman; A M Bowcock; R Baer; John D Minna
Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers.
Cancer research 2001;61(21):7943-9.
2001: Adi F Gazdar; John D Minna
Targeted therapies for killing tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10028-30.
2001: Shinichi Toyooka; Harvey I Pass; Narayan Shivapurkar; Yasuro Fukuyama; Riichiroh Maruyama; Kiyomi O Toyooka; Michael Z Gilcrease; Alfredo J Farinas; John D Minna; Adi F Gazdar
Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma.
Cancer research 2001;61(15):5727-30.
2001: Mai P Hoang; Anirban Maitra; Adi F Gazdar; Jorge Albores-Saavedra
Primary mammary small-cell carcinoma: a molecular analysis of 2 cases.
Human pathology 2001;32(7):753-7.
2001: Arvind K Virmani; Asha Rathi; Ubaradka G Sathyanarayana; Asha Padar; Chun Xian Huang; H T Cunnigham; Alfredo J Farinas; Sara Milchgrub; David M Euhus; Michael Z Gilcrease; James G Herman; John D Minna; Adi F Gazdar
Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1998-2004.
2001: Anirban Maitra; Ignacio I Wistuba; C Washington; Arvind K Virmani; Raheela Ashfaq; Sara Milchgrub; Adi F Gazdar; John D Minna
High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss.
The American journal of pathology 2001;159(1):119-30.
2001: Kiyomi O Toyooka; Shinichi Toyooka; Arvind K Virmani; Ubaradka G Sathyanarayana; David M Euhus; Michael Z Gilcrease; John D Minna; Adi F Gazdar
Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas.
Cancer research 2001;61(11):4556-60.
2001: David G Burbee; Eva Forgacs; Sabine Zöchbauer-Müller; Latha Shivakumar; Kwun Fong; Boning Gao; Dwight E Randle; Masashi Kondo; Arvind K Virmani; SA Bader; Yoshitaka Sekido; Farida Latif; Sara Milchgrub; Shinichi Toyooka; Adi F Gazdar; Michael I Lerman; Eugene R Zabarovsky; M White; John D Minna
Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.
Journal of the National Cancer Institute 2001;93(9):691-9.
2001: Sabine Zöchbauer-Müller; Kwun M Fong; Anirban Maitra; Stephen Lam; Joseph Geradts; Raheela Ashfaq; Arvind K Virmani; Sara Milchgrub; Adi F Gazdar; John D Minna
5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.
Cancer research 2001;61(9):3581-5.
2001: Anirban Maitra; Ignacio I Wistuba; Adi F Gazdar
Microdissection and the study of cancer pathways.
Current molecular medicine 2001;1(1):153-62.
2001: Arvind K Virmani; C Muller; Asha Rathi; S Zoechbauer-Mueller; Meredith A Mathis; Adi F Gazdar
Aberrant methylation during cervical carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3):584-9.
2001: Anirban Maitra; Asha Rathi; Adi F Gazdar; Arthur I Sagalowsky; Raheela Ashfaq
Expression of the RNA component of human telemorase (hTR) in ThinPrep preparations from bladder washings.
Cancer 2001;93(1):73-9.
2001: Eva Forgacs; Jonathan Wren; Craig Kamibayashi; Masashi Kondo; X L Xu; S Markowitz; Gail Tomlinson; Carolyn Y Muller; Adi F Gazdar; Harold R Garner; John D Minna
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 2001;20(8):1005-9.
2001: Bharat Jasani; Alfonso Cristaudo; Salih Emri; Adi F Gazdar; Allen Gibbs; B Krynska; C Miller; Luciano Mutti; C Radu; Mauro Tognon; antonio domenico procopio
Association of SV40 with human tumours.
Seminars in cancer biology 2001;11(1):49-61.
2001: Narayan Shivapurkar; Anirban Maitra; Sara Milchgrub; Adi F Gazdar
Deletions of chromosome 4 occur early during the pathogenesis of colorectal carcinoma.
Human pathology 2001;32(2):169-77.
2001: Anirban Maitra; Adi F Gazdar
Tissue microdissection and processing.
Cancer treatment and research 2001;106():63-84.
2001: Sabine Zöchbauer-Müller; Kwun M Fong; Arvind K Virmani; Joseph Geradts; Adi F Gazdar; John D Minna
Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
Cancer research 2001;61(1):249-55.
2000: Sabine Zöchbauer-Müller; Ignacio I Wistuba; J D Minna; Adi F Gazdar
Fragile histidine triad (FHIT) gene abnormalities in lung cancer.
Clinical lung cancer 2000;2(2):141-5.
2000: C Behrens; L B Travis; I I Wistuba; S Davis; Anirban Maitra; E A Clarke; C F Lynch; B Glimelius; T Wiklund; R Tarone; Adi F Gazdar
Molecular changes in second primary lung and breast cancers after therapy for Hodgkin's disease.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(10):1027-35.
2000: Jennifer B Sherwood; Narayan Shivapurkar; W Michael Lin; Raheela Ashfaq; David S Miller; Adi F Gazdar; Carolyn Y Muller
Chromosome 4 deletions are frequent in invasive cervical cancer and differ between histologic variants.
Gynecologic oncology 2000;79(1):90-6.
2000: Luc Girard; Sabine Zöchbauer-Müller; Arvind K Virmani; Adi F Gazdar; John D Minna
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
Cancer research 2000;60(17):4894-906.
2000: Anirban Maitra; DM Ramnani; Linda R Margraf; Adi F Gazdar
Synchronous wilms tumor and fibrolamellar hepatocellular carcinoma: report of a case.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2000;3(5):492-6.
2000: Arvind K Virmani; Asha Rathi; Sabine Zöchbauer-Müller; N Sacchi; Y Fukuyama; D Bryant; Anirban Maitra; Shashank Heda; Kwun M Fong; F Thunnissen; John D Minna; Adi F Gazdar
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Journal of the National Cancer Institute 2000;92(16):1303-7.
2000: Ignacio I Wistuba; Gail Tomlinson; C Behrens; Arvind K Virmani; Joseph Geradts; Joanne L Blum; John D Minna; Adi F Gazdar
Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome.
Genes, chromosomes & cancer 2000;28(4):359-69.
2000: W Michael Lin; Raheela Ashfaq; E A Michalopulos; Anirban Maitra; Adi F Gazdar; Carolyn Y Muller
Molecular Papanicolaou tests in the twenty-first century: molecular analyses with fluid-based Papanicolaou technology.
American journal of obstetrics and gynecology 2000;183(1):39-45.
2000: Ignacio I Wistuba; J Berry; Carmen Behrens; Anirban Maitra; Narayan Shivapurkar; Sara Milchgrub; Bruce Mackay; John D Minna; Adi F Gazdar
Molecular changes in the bronchial epithelium of patients with small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2604-10.
2000: Ignacio I Wistuba; Carmen Behrens; Arvind K Virmani; G Mele; Sara Milchgrub; Luc Girard; John W Fondon; Harold R Garner; B McKay; Farida Latif; Michael I Lerman; Stephen Lam; Adi F Gazdar; John D Minna
High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.
Cancer research 2000;60(7):1949-60.
2000: Sara Milchgrub; Ignacio I Wistuba; B K Kim; Cynthia Rutherford; J Urban; Ponciano D Cruz; Adi F Gazdar
Molecular identification of metastatic cancer to the skin using laser capture microdissection: a case report.
Cancer 2000;88(4):749-54.
2000: Ignacio I Wistuba; Adi F Gazdar
Molecular pathology of lung cancer.
Verhandlungen der Deutschen Gesellschaft für Pathologie 2000;84():96-105.
1999: David M Euhus; Anirban Maitra; Ignacio I Wistuba; Raheela Ashfaq; A Alberts; D Gibbons; Adi F Gazdar
Use of archival fine-needle aspirates for the allelotyping of tumors.
Cancer 1999;87(6):372-9.
1999: Anirban Maitra; Fattaneh A Tavassoli; Jorge Albores-Saavedra; Carmen Behrens; Ignacio I Wistuba; D Bryant; Arthur G Weinberg; Beverly B Rogers; M Hossein Saboorian; Adi F Gazdar
Molecular abnormalities associated with secretory carcinomas of the breast.
Human pathology 1999;30(12):1435-40.
1999: Narayan Shivapurkar; Thorsten Wiethege; Ignacio I Wistuba; E Salomon; Sara Milchgrub; KM Muller; A Churg; Harvey I Pass; Adi F Gazdar
Presence of simian virus 40 sequences in malignant mesotheliomas and mesothelial cell proliferations.
Journal of cellular biochemistry 1999;76(2):181-8.
1999: I W Park; Ignacio I Wistuba; Anirban Maitra; Sara Milchgrub; Arvind K Virmani; John D Minna; Adi F Gazdar
Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer.
Journal of the National Cancer Institute 1999;91(21):1863-8.
1999: R Delgado; Asha Rathi; Jorge Albores-Saavedra; Adi F Gazdar
Expression of the RNA component of human telomerase in adult testicular germ cell neoplasia.
Cancer 1999;86(9):1802-11.
1999: Ignacio I Wistuba; S Syed; Carmen Behrens; M Duong; Sara Milchgrub; Carolyn Y Muller; Jaishree Jagirdar; Adi F Gazdar
Comparison of molecular changes in cervical intraepithelial neoplasia in HIV-positive and HIV-indeterminate subjects.
Gynecologic oncology 1999;74(3):519-26.
1999: Anirban Maitra; Ignacio I Wistuba; D Gibbons; Adi F Gazdar; Jorge Albores-Saavedra
Allelic losses at chromosome 3p are seen in human papilloma virus 16 associated transitional cell carcinoma of the cervix.
Gynecologic oncology 1999;74(3):361-8.
1999: Anirban Maitra; S Salahuddin; Charles F Timmons; Adi F Gazdar
Allelotyping nephrogenic rests: putative precursor lesions of Wilms tumors.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 1999;2(5):488-9.
1999: Narayan Shivapurkar; S Sood; Ignacio I Wistuba; Arvind K Virmani; Anirban Maitra; Sara Milchgrub; John D Minna; Adi F Gazdar
Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas.
Cancer research 1999;59(15):3576-80.
1999: Ignacio I Wistuba; C Behrens; Adi F Gazdar
Pathogenesis of non-AIDS-defining cancers: a review.
AIDS patient care and STDs 1999;13(7):415-26.
1999: L C Flowers; Ignacio I Wistuba; J Scurry; Carolyn Y Muller; Raheela Ashfaq; David S Miller; John D Minna; Adi F Gazdar
Genetic changes during the multistage pathogenesis of human papillomavirus positive and negative vulvar carcinomas.
Journal of the Society for Gynecologic Investigation 1999;6(4):213-21.
1999: DM Ramnani; Ignacio I Wistuba; Carmen Behrens; Adi F Gazdar; Leslie H Sobin; Jorge Albores-Saavedra
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
Cancer 1999;86(1):14-21.
1999: S S Wang; Arvind K Virmani; Adi F Gazdar; John D Minna; Glen A Evans
Refined mapping of two regions of loss of heterozygosity on chromosome band 11q23 in lung cancer.
Genes, chromosomes & cancer 1999;25(2):154-9.
1999: Ignacio I Wistuba; D Bryant; Carmen Behrens; Sara Milchgrub; Arvind K Virmani; Raheela Ashfaq; John D Minna; Adi F Gazdar
Comparison of features of human lung cancer cell lines and their corresponding tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(5):991-1000.
1999: David M Euhus; Anirban Maitra; Ignacio I Wistuba; A Alberts; Jorge Albores-Saavedra; Adi F Gazdar
Loss of heterozygosity at 3p in benign lesions preceding invasive breast cancer.
The Journal of surgical research 1999;83(1):13-8.
1999: Stephen Lam; Jean C leRiche; Y Zheng; Andrew J Coldman; Calum MacAulay; Ernest T Hawk; G Kelloff; Adi F Gazdar
Sex-related differences in bronchial epithelial changes associated with tobacco smoking.
Journal of the National Cancer Institute 1999;91(8):691-6.
1999: Ignacio I Wistuba; Carmen Behrens; Arvind K Virmani; Sara Milchgrub; S Syed; Stephen Lam; Bruce Mackay; John D Minna; Adi F Gazdar
Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer.
Cancer research 1999;59(8):1973-9.
1999: Weiguo Wu; Bonnie L Kemp; ML Proctor; Adi F Gazdar; John D Minna; Waun Ki Hong; Li Mao
Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer.
Cancer research 1999;59(8):1846-51.
1999: Anirban Maitra; K Yashima; Asha Rathi; Charles F Timmons; Beverly B Rogers; Jerry W Shay; Adi F Gazdar
The RNA component of telomerase as a marker of biologic potential and clinical outcome in childhood neuroblastic tumors.
Cancer 1999;85(3):741-9.
1999: N Onuki; Ignacio I Wistuba; William D Travis; Arvind K Virmani; K Yashima; Elizabeth Brambilla; P Hasleton; Adi F Gazdar
Genetic changes in the spectrum of neuroendocrine lung tumors.
Cancer 1999;85(3):600-7.
1999: Masahiro Sakaguchi; Arvind K Virmani; Raheela Ashfaq; Thomas E Rogers; Asha Rathi; Y Liu; DR Kodagoda; H Thomas Cunningham; Adi F Gazdar
Development of a sensitive, specific reverse transcriptase polymerase chain reaction-based assay for epithelial tumour cells in effusions.
British journal of cancer 1999;79(3-4):416-22.
1999: Ignacio I Wistuba; Carmen Behrens; Sara Milchgrub; D Bryant; Jaclyn Y Hung; John D Minna; Adi F Gazdar
Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma.
Oncogene 1999;18(3):643-50.
1999: Elisabeth J Rushing; S M Colvin; Adi F Gazdar; N Miura; Charles L White; CP Coimbra; D K Burns
Prognostic value of proliferation index and expression of the RNA component of human telomerase (hTR) in papillary meningiomas.
Journal of neuro-oncology 1999;45(3):199-207.
1999: Ignacio I Wistuba; Juan Miquel; Adi F Gazdar; Jorge Albores-Saavedra
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Human pathology 1999;30(1):21-5.
1999: Narayan Shivapurkar; Arvind K Virmani; Ignacio I Wistuba; Sara Milchgrub; Bruce Mackay; John D Minna; Adi F Gazdar
Deletions of chromosome 4 at multiple sites are frequent in malignant mesothelioma and small cell lung carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(1):17-23.
1999: Ignacio I Wistuba; B Thomas; Carmen Behrens; N Onuki; Guy Lindberg; Jorge Albores-Saavedra; Adi F Gazdar
Molecular abnormalities associated with endocrine tumors of the uterine cervix.
Gynecologic oncology 1999;72(1):3-9.
1998: Adi F Gazdar; V Kurvari; Arvind K Virmani; Lauren S Gollahon; Masahiro Sakaguchi; M Westerfield; DR Kodagoda; V Stasny; H Thomas Cunningham; Ignacio I Wistuba; Gail Tomlinson; Vijay S Tonk; Raheela Ashfaq; A Marilyn Leitch; John D Minna; Jerry W Shay
Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer.
International journal of cancer. Journal international du cancer 1998;78(6):766-74.
1998: Ignacio I Wistuba; Carmen Behrens; Sara Milchgrub; S Syed; M Ahmadian; Arvind K Virmani; V Kurvari; T H Cunningham; Raheela Ashfaq; John D Minna; Adi F Gazdar
Comparison of features of human breast cancer cell lines and their corresponding tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):2931-8.
1998: S S Wang; EDWARD ESPLIN; J L Li; L Huang; Adi F Gazdar; John D Minna; Glen A Evans
Alterations of the PPP2R1B gene in human lung and colon cancer.
Science (New York, N.Y.) 1998;282(5387):284-7.
1998: Eva Forgacs; EJ Biesterveld; Yoshitaka Sekido; Kwun Fong; Sabeeha Muneer; Ignacio I Wistuba; Sara Milchgrub; Ruth I Brezinschek; Arvind K Virmani; Adi F Gazdar; John D Minna
Mutation analysis of the PTEN/MMAC1 gene in lung cancer.
Oncogene 1998;17(12):1557-65.
1998: Y Oh; ML Proctor; You-Hong Fan; Li-Kuo Su; Waun Ki Hong; Kwun M Fong; Y S Sekido; Adi F Gazdar; John D Minna; Li Mao
TSG101 is not mutated in lung cancer but a shortened transcript is frequently expressed in small cell lung cancer.
Oncogene 1998;17(9):1141-8.
1998: K Yashima; Anirban Maitra; Beverly B Rogers; Charles F Timmons; Asha Rathi; H Pinar; W E Wright; Jerry W Shay; Adi F Gazdar
Expression of the RNA component of telomerase during human development and differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(9):805-13.
1998: Gail Tomlinson; Tina T-L Chen; Victor Stastny; Arvind K Virmani; M A Spillman; Vijay S Tonk; Joanne L Blum; N R Schneider; Ignacio I Wistuba; Jerry W Shay; John D Minna; Adi F Gazdar
Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.
Cancer research 1998;58(15):3237-42.
1998: Yoshitaka Sekido; M Ahmadian; Ignacio I Wistuba; Farida Latif; SA Bader; Ming-Hui Wei; Fuh-Mei Duh; Adi F Gazdar; Michael I Lerman; John D Minna
Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene.
Oncogene 1998;16(24):3151-7.
1998: Ignacio I Wistuba; Carmen Behrens; Sara Milchgrub; Arvind K Virmani; Jaishree Jagirdar; B Thomas; H L Ioachim; L A Litzky; E M Brambilla; John D Minna; Adi F Gazdar
Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects.
JAMA : the journal of the American Medical Association 1998;279(19):1554-9.
1998: Arvind K Virmani; Vijay S Tonk; Adi F Gazdar
Comparison between fluorescence in situ hybridization and classical cytogenetics in human tumors.
Anticancer research 1998;18(3A):1351-6.
1998: K Yashima; Anirban Maitra; Charles F Timmons; Beverly B Rogers; H Pinar; Jerry W Shay; Adi F Gazdar
Expression of the RNA component of telomerase in Wilms tumor and nephrogenic rest recapitulates renal embryogenesis.
Human pathology 1998;29(5):536-42.
1998: Y Yamamoto; I I Wistuba; Y Kishimoto; A K Virmani; F Vuitch; Jorge Albores-Saavedra; Adi F Gazdar
DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining.
Pathology international 1998;48(4):273-80.
1998: Y Yamamoto; Y Kishimoto; I I Wistuba; A K Virmani; F Vuitch; Adi F Gazdar; Jorge Albores-Saavedra
DNA analysis at p53 locus in carcinomas arising from pleomorphic adenomas of salivary glands: comparison of molecular study and p53 immunostaining.
Pathology international 1998;48(4):265-72.
1998: Arvind K Virmani; Kwun M Fong; DR Kodagoda; D McIntire; Jaclyn Y Hung; Vijay S Tonk; John D Minna; Adi F Gazdar
Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.
Genes, chromosomes & cancer 1998;21(4):308-19.
1998: K Yashima; Raheela Ashfaq; Jan Anthony Nowak; Vivian E von Gruenigen; Sara Milchgrub; Asha Rathi; Jorge Albores-Saavedra; Jerry W Shay; Adi F Gazdar
Telomerase activity and expression of its RNA component in cervical lesions.
Cancer 1998;82(7):1319-27.
1998: Carolyn Y Muller; JD O'Boyle; Kwun M Fong; Ignacio I Wistuba; EJ Biesterveld; M Ahmadian; David S Miller; Adi F Gazdar; John D Minna
Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type.
Journal of the National Cancer Institute 1998;90(6):433-9.
1998: Stephen Lam; Tim Kennedy; M Unger; York E Miller; D Gelmont; Valerie W Rusch; B Gipe; D Howard; Jean C leRiche; Andrew J Coldman; Adi F Gazdar
Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy.
Chest 1998;113(3):696-702.
1998: K Yashima; Sara Milchgrub; Lauren S Gollahon; Anirban Maitra; M Hossein Saboorian; Jerry W Shay; Adi F Gazdar
Telomerase enzyme activity and RNA expression during the multistage pathogenesis of breast carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):229-34.
1997: K Yashima; F Vuitch; Adi F Gazdar; TJ Fahey
Telomerase activity in benign and malignant thyroid diseases.
Surgery 1997;122(6):1141-5; discussion 1145-6.
1997: DF Brown; Adi F Gazdar; Charles L White; K Yashima; Jerry W Shay; Elisabeth J Rushing
Human telomerase RNA expression and MIB-1 (Ki-67) proliferation index distinguish hemangioblastomas from metastatic renal cell carcinomas.
Journal of neuropathology and experimental neurology 1997;56(12):1349-55.
1997: Elisabeth J Rushing; K Yashima; DF Brown; Charles L White; Jerry W Shay; RC Risser; Adi F Gazdar
Expression of telomerase RNA component correlates with the MIB-1 proliferation index in ependymomas.
Journal of neuropathology and experimental neurology 1997;56(10):1142-6.
1997: Ignacio I Wistuba; Stephen Lam; Carmen Behrens; Arvind K Virmani; Kwun M Fong; J LeRiche; Jonathan M Samet; sudhir srivastava; John D Minna; Adi F Gazdar
Molecular damage in the bronchial epithelium of current and former smokers.
Journal of the National Cancer Institute 1997;89(18):1366-73.
1997: M Ahmadian; Ignacio I Wistuba; Kwun M Fong; Carmen Behrens; DR Kodagoda; M Hossein Saboorian; Jerry W Shay; Gail Tomlinson; J Blum; John D Minna; Adi F Gazdar
Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands.
Cancer research 1997;57(17):3664-8.
1997: Ignacio I Wistuba; F D Montellano; Sara Milchgrub; Arvind K Virmani; Carmen Behrens; Hong Chen; M Ahmadian; Jan Anthony Nowak; C Muller; John D Minna; Adi F Gazdar
Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma.
Cancer research 1997;57(15):3154-8.
1997: K Yashima; L A Litzky; L Kaiser; T Rogers; Stephen Lam; Ignacio I Wistuba; Sara Milchgrub; sudhir srivastava; M A Piatyszek; Jerry W Shay; Adi F Gazdar
Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas.
Cancer research 1997;57(12):2373-7.
1997: K Sugio; Kyle H Molberg; Jorge Albores-Saavedra; Arvind K Virmani; Y Kishimoto; Adi F Gazdar
K-ras mutations and allelic loss at 5q and 18q in the development of human pancreatic cancers.
International journal of pancreatology : official journal of the International Association of Pancreatology 1997;21(3):205-17.
1997: Kwun M Fong; EJ Biesterveld; Arvind K Virmani; Ignacio I Wistuba; Yoshitaka Sekido; SA Bader; M Ahmadian; ST Ong; Feyruz V Rassool; Paul V Zimmerman; G Giaccone; Adi F Gazdar; John D Minna
FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.
Cancer research 1997;57(11):2256-67.
1997: K Yashima; M A Piatyszek; H M Saboorian; A K Virmani; D Brown; Jerry W Shay; Adi F Gazdar
Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes.
Journal of clinical pathology 1997;50(2):110-7.
1997: F Vuitch; Yoshitaka Sekido; Kwun Fong; Bruce Mackay; John D Minna; Adi F Gazdar
Neuroendocrine tumors of the lung. Pathology and molecular biology.
Chest surgery clinics of North America 1997;7(1):21-47.
1996: Y Yamamoto; Arvind K Virmani; Ignacio I Wistuba; D McIntire; F Vuitch; Jorge Albores-Saavedra; Adi F Gazdar
Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands.
Human pathology 1996;27(11):1204-10.
1996: John D Minna; Adi F Gazdar
Translational research comes of age.
Nature medicine 1996;2(9):974-5.
1996: Y Yamamoto; Y Kishimoto; Arvind K Virmani; A Smith; F Vuitch; Jorge Albores-Saavedra; Adi F Gazdar
Mutations associated with carcinomas arising from pleomorphic adenomas of the salivary glands.
Human pathology 1996;27(8):782-6.
1996: Bruce E Johnson; J D Bridges; M Sobczeck; J Gray; RI Linnoila; Adi F Gazdar; L Hankins; Seth M Steinberg; M Edison; J N Frame; Harvey I Pass; J Nesbitt; D Holden; James L Mulshine; E Glatstein; D C Ihde
Patients with limited-stage small-cell lung cancer treated with concurrent twice-daily chest radiotherapy and etoposide/cisplatin followed by cyclophosphamide, doxorubicin, and vincristine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(3):806-13.
1996: Eiso Hiyama; Lauren S Gollahon; T Kataoka; K Kuroi; Takashi Yokoyama; Adi F Gazdar; Keiko Hiyama; M A Piatyszek; Jerry W Shay
Telomerase activity in human breast tumors.
Journal of the National Cancer Institute 1996;88(2):116-22.
1996: Bruce E Johnson; E Russell; A M Simmons; R Phelps; Seth M Steinberg; D C Ihde; Adi F Gazdar
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
Journal of cellular biochemistry. Supplement 1996;24():210-7.
1996: G L Shaw; Adi F Gazdar; R Phelps; Seth M Steinberg; RI Linnoila; Bruce E Johnson; H K Oie; E K Russell; B C Ghosh; Harvey I Pass; John D Minna; James L Mulshine; D C Ihde
Correlation of in vitro drug sensitivity testing results with response to chemotherapy and survival: comparison of non-small cell lung cancer and small cell lung cancer.
Journal of cellular biochemistry. Supplement 1996;24():173-85.
1996: R M Phelps; Bruce E Johnson; D C Ihde; Adi F Gazdar; D P Carbone; P R McClintock; RI Linnoila; M J Matthews; P A Bunn; D Carney; John D Minna; James L Mulshine
NCI-Navy Medical Oncology Branch cell line data base.
Journal of cellular biochemistry. Supplement 1996;24():32-91.
1996: H K Oie; E K Russell; D N Carney; Adi F Gazdar
Cell culture methods for the establishment of the NCI series of lung cancer cell lines.
Journal of cellular biochemistry. Supplement 1996;24():24-31.
1996: Chun-Ming Tsai; Reury-Perng Perng; K T Chang; D Venzon; Adi F Gazdar
Evaluation of the relative cytotoxic effects of anticancer agents in serum-supplemented versus serum-free media using a tetrazolium colorimetric assay.
Japanese journal of cancer research : Gann 1996;87(1):91-7.
1996: Chun-Ming Tsai; K T Chang; L H Wu; J Y Chen; Adi F Gazdar; T Mitsudomi; M H Chen; Reury-Perng Perng
Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines.
Cancer research 1996;56(1):206-9.
1995: F J Burrows; E J Derbyshire; P L Tazzari; P Amlot; Adi F Gazdar; S W King; M Letarte; Ellen S Vitetta; Philip E Thorpe
Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(12):1623-34.
1995: I F Ciernik; B H Krayenbühl Ciernik; Clay J Cockerell; John D Minna; Adi F Gazdar; David P Carbone
Expression of transforming growth factor beta and transforming growth factor beta receptors on AIDS-associated Kaposi's sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(10):1119-24.
1995: Y Kishimoto; K Sugio; Jaclyn Y Hung; Arvind K Virmani; D D McIntire; John D Minna; Adi F Gazdar
Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers.
Journal of the National Cancer Institute 1995;87(16):1224-9.
1995: David I Rosenthal; L G Close; Joseph Lucci; S C Schold; John M Truelson; H Fathallah-Skaykh; Barton A. Kamen; F Vuitch; Adi F Gazdar; James C Griener
Phase I studies of continuous-infusion paclitaxel given with standard aggressive radiation therapy for locally advanced solid tumors.
Seminars in oncology 1995;22(4 Suppl 9):13-7.
1995: Jaclyn Y Hung; Y Kishimoto; K Sugio; Arvind K Virmani; D D McIntire; John D Minna; Adi F Gazdar
Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma.
JAMA : the journal of the American Medical Association 1995;273(24):1908.
1995: Keiko Hiyama; Eiso Hiyama; S Ishioka; M Yamakido; K Inai; Adi F Gazdar; M A Piatyszek; Jerry W Shay
Telomerase activity in small-cell and non-small-cell lung cancers.
Journal of the National Cancer Institute 1995;87(12):895-902.
1995: Ignacio I Wistuba; K Sugio; Jaclyn Y Hung; Y Kishimoto; Arvind K Virmani; I Roa; Jorge Albores-Saavedra; Adi F Gazdar
Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile.
Cancer research 1995;55(12):2511-5.
1995: Yoshitaka Sekido; Harvey I Pass; SA Bader; D J Mew; M F Christman; Adi F Gazdar; John D Minna
Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer.
Cancer research 1995;55(6):1227-31.
1995: Jaclyn Y Hung; Y Kishimoto; K Sugio; Arvind K Virmani; D D McIntire; John D Minna; Adi F Gazdar
Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma.
JAMA : the journal of the American Medical Association 1995;273(7):558-63.
1995: Y Kishimoto; K Sugio; T Mitsudomi; T Oyama; Arvind K Virmani; D D McIntire; Adi F Gazdar
Frequent loss of the short arm of chromosome 9 in resected non-small-cell lung cancers from Japanese patients and its association with squamous cell carcinoma.
Journal of cancer research and clinical oncology 1995;121(5):291-6.
1994: D P Carbone; T Mitsudomi; I Chiba; Steven Piantadosi; Valerie W Rusch; Jan Anthony Nowak; D McIntire; Dennis J Slamon; Adi F Gazdar; John D Minna
p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. A preliminary report of LCSG 871.
Chest 1994;106(6 Suppl):377S-381S.
1994: K Sugio; Y Kishimoto; Arvind K Virmani; Jaclyn Y Hung; Adi F Gazdar
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
Cancer research 1994;54(22):5811-5.
1994: D C Ihde; James L Mulshine; B S Kramer; Seth M Steinberg; RI Linnoila; Adi F Gazdar; M Edison; R M Phelps; M Lesar; J C Phares
Prospective randomized comparison of high-dose and standard-dose etoposide and cisplatin chemotherapy in patients with extensive-stage small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(10):2022-34.
1994: Yoshitaka Sekido; SA Bader; Farida Latif; J R Gnarra; Adi F Gazdar; W M Linehan; Berton Zbar; Michael I Lerman; John D Minna
Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.
Oncogene 1994;9(6):1599-604.
1994: James L Mulshine; Bruce E Johnson; Adi F Gazdar; G L Shaw; B S Kramer; T Mitsudomi; John D Minna; Harvey I Pass; R Phelps; B Ghosh
Integrated clinical and basic studies related to circumventing non-small cell lung cancer drug resistance.
Lung cancer (Amsterdam, Netherlands) 1994;10 Suppl 1():S73-81.
1994: Adi F Gazdar
The molecular and cellular basis of human lung cancer.
Anticancer research 1994;14(1B):261-7.
1994: Adi F Gazdar; SA Bader; Jaclyn Y Hung; Y Kishimoto; Yoshitaka Sekido; K Sugio; Arvind K Virmani; Jason Fleming; David P Carbone; John D Minna
Molecular genetic changes found in human lung cancer and its precursor lesions.
Cold Spring Harbor symposia on quantitative biology 1994;59():565-72.
1993: S F Winter; Yoshitaka Sekido; John D Minna; D McIntire; Bruce E Johnson; Adi F Gazdar; David P Carbone
Antibodies against autologous tumor cell proteins in patients with small-cell lung cancer: association with improved survival.
Journal of the National Cancer Institute 1993;85(24):2012-8.
1993: G L Shaw; Adi F Gazdar; R Phelps; RI Linnoila; D C Ihde; Bruce E Johnson; H K Oie; Harvey I Pass; Seth M Steinberg; B C Ghosh
Individualized chemotherapy for patients with non-small cell lung cancer determined by prospective identification of neuroendocrine markers and in vitro drug sensitivity testing.
Cancer research 1993;53(21):5181-7.
1993: J A Kern; L Torney; D Weiner; Adi F Gazdar; H M Shepard; B Fendly
Inhibition of human lung cancer cell line growth by an anti-p185HER2 antibody.
American journal of respiratory cell and molecular biology 1993;9(4):448-54.
1993: T Mitsudomi; S Lam; T Shirakusa; Adi F Gazdar
Detection and sequencing of p53 gene mutations in bronchial biopsy samples in patients with lung cancer.
Chest 1993;104(2):362-5.
1993: Chun-Ming Tsai; K T Chang; Reury-Perng Perng; T Mitsudomi; M H Chen; C Kadoyama; Adi F Gazdar
Correlation of intrinsic chemoresistance of non-small-cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutations.
Journal of the National Cancer Institute 1993;85(11):897-901.
1993: Olufunmilayo I Olopade; D L Buchhagen; K Malik; J Sherman; T Nobori; SA Bader; Marion M Nau; Adi F Gazdar; John D Minna; Manuel O Diaz
Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.
Cancer research 1993;53(10 Suppl):2410-5.
1993: RI Linnoila; Adi F Gazdar; K Funa; K L Becker
Long-term selective culture of hamster pulmonary endocrine cells.
The Anatomical record 1993;236(1):231-40.
1993: Chun-Ming Tsai; S H Hsiao; C M Frey; K T Chang; Reury-Perng Perng; Adi F Gazdar; B S Kramer
Combination cytotoxic effects of cis-diamminedichloroplatinum(II) and 5-fluorouracil with and without leucovorin against human non-small cell lung cancer cell lines.
Cancer research 1993;53(5):1079-84.
1992: J Kim; Frederic J Kaye; J G Henslee; J E Shively; J G Park; S L Lai; R I Linnoila; James L Mulshine; Adi F Gazdar
Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers.
International journal of cancer. Journal international du cancer 1992;52(5):718-25.
1992: Adi F Gazdar
The molecular biology of lung cancer.
The Tohoku journal of experimental medicine 1992;168(2):239-45.
1992: S F Winter; John D Minna; Bruce E Johnson; T Takahashi; Adi F Gazdar; David P Carbone
Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation.
Cancer research 1992;52(15):4168-74.
1992: Y Ohsaki; Adi F Gazdar; H C Chen; Bruce E Johnson
Antitumor activity of magainin analogues against human lung cancer cell lines.
Cancer research 1992;52(13):3534-8.
1992: G Kaur; J Viallet; Jorge Laborda; O Blair; Adi F Gazdar; John D Minna; Edward A Sausville
Growth inhibition by cholera toxin of human lung carcinoma cell lines: correlation with GM1 ganglioside expression.
Cancer research 1992;52(12):3340-6.
1992: G Giaccone; J Battey; Adi F Gazdar; H Oie; M Draoui; Terry W Moody
Neuromedin B is present in lung cancer cell lines.
Cancer research 1992;52(9 Suppl):2732s-2736s.
1992: S M Bodner; John D Minna; S M Jensen; D D'Amico; D Carbone; T Mitsudomi; J Fedorko; D L Buchhagen; Marion M Nau; Adi F Gazdar
Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.
Oncogene 1992;7(4):743-9.
1992: G Giaccone; Adi F Gazdar; H Beck; F Zunino; G Capranico
Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.
Cancer research 1992;52(7):1666-74.
1992: J A Kern; Robert A Robinson; Adi F Gazdar; L Torney; David B Weiner
Mechanisms of p185HER2 expression in human non-small cell lung cancer cell lines.
American journal of respiratory cell and molecular biology 1992;6(4):359-63.
1992: Adi F Gazdar
Molecular markers for the diagnosis and prognosis of lung cancer.
Cancer 1992;69(6 Suppl):1592-9.
1992: J L Broers; S M Jensen; William D Travis; Harvey I Pass; J A Whitsett; G Singh; S L Katyal; Adi F Gazdar; John D Minna; RI Linnoila
Expression of surfactant associated protein-A and Clara cell 10 kilodalton mRNA in neoplastic and non-neoplastic human lung tissue as detected by in situ hybridization.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):337-46.
1992: RI Linnoila; S M Jensen; Seth M Steinberg; James L Mulshine; J C Eggleston; Adi F Gazdar
Peripheral airway cell marker expression in non-small cell lung carcinoma. Association with distinct clinicopathologic features.
American journal of clinical pathology 1992;97(2):233-43.
1992: RI Linnoila; James L Mulshine; Seth M Steinberg; Adi F Gazdar
Expression of surfactant-associated protein in non-small-cell lung cancer: a discriminant between biologic subsets.
Journal of the National Cancer Institute. Monographs 1992;(13):61-6.
1992: Bruce E Johnson; J F Brennan; D C Ihde; Adi F Gazdar
myc family DNA amplification in tumors and tumor cell lines from patients with small-cell lung cancer.
Journal of the National Cancer Institute. Monographs 1992;(13):39-43.
1992: Adi F Gazdar; C Kadoyama; D Venzon; J G Park; C M Tsai; RI Linnoila; James L Mulshine; D C Ihde; G Giaccone
Association between histological type and neuroendocrine differentiation on drug sensitivity of lung cancer cell lines.
Journal of the National Cancer Institute. Monographs 1992;(13):191-6.
1992: M Lee; M Draoui; Farah zia; Adi F Gazdar; H Oie; Gerold Bepler; F Bellot; C Tarr; R Kris; Terry W Moody
Epidermal growth factor receptor monoclonal antibodies inhibit the growth of lung cancer cell lines.
Journal of the National Cancer Institute. Monographs 1992;(13):117-23.
1991: David P Carbone; A M Koros; RI Linnoila; P Jewett; Adi F Gazdar
Neural cell adhesion molecule expression and messenger RNA splicing patterns in lung cancer cell lines are correlated with neuroendocrine phenotype and growth morphology.
Cancer research 1991;51(22):6142-9.
1991: T Mitsudomi; Seth M Steinberg; H K Oie; James L Mulshine; R Phelps; J Viallet; Harvey I Pass; John D Minna; Adi F Gazdar
ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent.
Cancer research 1991;51(18):4999-5002.
1991: T Mitsudomi; J Viallet; James L Mulshine; RI Linnoila; John D Minna; Adi F Gazdar
Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines.
Oncogene 1991;6(8):1353-62.
1991: J H Kim; T Takahashi; I Chiba; J G Park; Michael J Birrer; J K Roh; H De Lee; J P Kim; John D Minna; Adi F Gazdar
Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.
Journal of the National Cancer Institute 1991;83(13):938-43.
1991: J Whang-Peng; Turid Knutsen; Adi F Gazdar; Seth M Steinberg; H Oie; I Linnoila; J Mulshine; Marion M Nau; John D Minna
Nonrandom structural and numerical chromosome changes in non-small-cell lung cancer.
Genes, chromosomes & cancer 1991;3(3):168-88.
1991: J Brennan; T O'Connor; R W Makuch; A M Simmons; E Russell; RI Linnoila; R M Phelps; Adi F Gazdar; D C Ihde; Bruce E Johnson
myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens.
Cancer research 1991;51(6):1708-12.
1991: C M Tsai; Adi F Gazdar; Reury-Perng Perng; B S Kramer
Schedule-dependent in vitro combination effects of methotrexate and 5-fluorouracil in human tumor cell lines.
International journal of cancer. Journal international du cancer 1991;47(3):401-7.
1990: H Stevenson; Adi F Gazdar; R Phelps; RI Linnoila; D C Ihde; B Ghosh; THOMAS WALSH; E L Woods; H Oie; T O'Connor
Tumor cell lines established in vitro: an independent prognostic factor for survival in non-small-cell lung cancer.
Annals of internal medicine 1990;113(10):764-70.
1990: S M Jensen; Adi F Gazdar; Frank Cuttitta; E K Russell; RI Linnoila
A comparison of synaptophysin, chromogranin, and L-dopa decarboxylase as markers for neuroendocrine differentiation in lung cancer cell lines.
Cancer research 1990;50(18):6068-74.
1990: Adi F Gazdar; H K Oie; C H Shackleton; T R Chen; Timothy Triche; C E Myers; G P Chrousos; Murray F Brennan; Cy A Stein; R V La Rocca
Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.
Cancer research 1990;50(17):5488-96.
1990: Adi F Gazdar; RI Linnoila; Y Kurita; H K Oie; James L Mulshine; J C Clark; J A Whitsett
Peripheral airway cell differentiation in human lung cancer cell lines.
Cancer research 1990;50(17):5481-7.
1990: Rafael Fridman; G Giaccone; T Kanemoto; G R Martin; Adi F Gazdar; J L Mulshine
Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6698-702.
1990: G Giaccone; C Kadoyama; R Maneckjee; D Venzon; Richard B Alexander; Adi F Gazdar
Effects of tumor necrosis factor, alone or in combination with topoisomerase-II-targeted drugs, on human lung cancer cell lines.
International journal of cancer. Journal international du cancer 1990;46(2):326-9.
1990: Ethan Dmitrovsky; E J Seifter; Adi F Gazdar; C M Tsai; M Edison; P Brantley; S R Veach; G Batist; D C Ihde; James L Mulshine
A phase II trial of carboplatin (CBDCA) in small-cell and non-small-cell lung cancer with correlation to in vitro analysis of cytotoxicity.
American journal of clinical oncology 1990;13(4):285-9.
1990: Terry W Moody; M Lee; R M Kris; F Bellot; Gerold Bepler; H Oie; Adi F Gazdar
Lung carcinoid cell lines have bombesin-like peptides and EGF receptors.
Journal of cellular biochemistry 1990;43(2):139-47.
1990: Adi F Gazdar
Cell biology and molecular biology of small cell and non-small cell lung cancer.
Current opinion in oncology 1990;2(2):321-7.
1990: D P Bliss; James F Battey; RI Linnoila; Michael J Birrer; Adi F Gazdar; Bruce E Johnson
Expression of the atrial natriuretic factor gene in small cell lung cancer tumors and tumor cell lines.
Journal of the National Cancer Institute 1990;82(4):305-10.
1990: J G Park; B S Kramer; S L Lai; L J Goldstein; Adi F Gazdar
Chemosensitivity patterns and expression of human multidrug resistance-associated MDR1 gene by human gastric and colorectal carcinoma cell lines.
Journal of the National Cancer Institute 1990;82(3):193-8.
1990: Adi F Gazdar; Seth M Steinberg; E K Russell; RI Linnoila; H K Oie; B C Ghosh; J D Cotelingam; Bruce E Johnson; John D Minna; D C Ihde
Correlation of in vitro drug-sensitivity testing results with response to chemotherapy and survival in extensive-stage small cell lung cancer: a prospective clinical trial.
Journal of the National Cancer Institute 1990;82(2):117-24.
1990: David B Weiner; J Nordberg; R Robinson; Peter C Nowell; Adi F Gazdar; Mark I Greene; William V Williams; J A Cohen; J A Kern
Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung.
Cancer research 1990;50(2):421-5.
1990: J. William Harbour; S L Lai; Adi F Gazdar; J D Minna; Frederic J Kaye
Expression in lung cancer of a transcribed sequence at the DNF15S2 locus at chromosome 3P21.
Anticancer research 1990;10(1):23-7.
1990: M L Levitt; Adi F Gazdar; H K Oie; H Schuller; Scott Thacher
Cross-linked envelope-related markers for squamous differentiation in human lung cancer cell lines.
Cancer research 1990;50(1):120-8.
1990: Adi F Gazdar; J L Mulshine; B S Kramer
Biological, molecular, and clinical markers for the diagnosis and typing of lung cancer.
Immunology series 1990;53():453-68.
1990: C M Tsai; D C Ihde; C Kadoyama; D Venzon; Adi F Gazdar
Correlation of in vitro drug sensitivity testing of long-term small cell lung cancer cell lines with response and survival.
European journal of cancer (Oxford, England : 1990) 1990;26(11-12):1148-52.
1989: T Takahashi; Marion M Nau; I Chiba; Michael J Birrer; R K Rosenberg; M Vinocour; M Levitt; Harvey I Pass; Adi F Gazdar; John D Minna
p53: a frequent target for genetic abnormalities in lung cancer.
Science (New York, N.Y.) 1989;246(4929):491-4.
1989: Bruce E Johnson; J Whang-Peng; Susan Naylor; Berton Zbar; H Brauch; E Lee; A Simmons; E Russell; M H Nam; Adi F Gazdar
Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies.
Journal of the National Cancer Institute 1989;81(16):1223-8.
1989: S L Lai; L J Goldstein; Michael M Gottesman; Ira Pastan; C M Tsai; Bruce E Johnson; James L Mulshine; D C Ihde; K Kayser; Adi F Gazdar
MDR1 gene expression in lung cancer.
Journal of the National Cancer Institute 1989;81(15):1144-50.
1989: H C Stevenson; Adi F Gazdar; RI Linnoila; E K Russell; H K Oie; Seth M Steinberg; D C Ihde
Lack of relationship between in vitro tumor cell growth and prognosis in extensive-stage small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(7):923-31.
1989: Adi F Gazdar
Innovative chemotherapy. Xenografts and in vitro drug sensitivity testing.
Chest 1989;96(1 Suppl):56S-59S.
1989: Adi F Gazdar
Advances in the biology of lung cancer. Clinical significance of neuroendocrine differentiation.
Chest 1989;96(1 Suppl):39S-41S.
1989: C M Tsai; Adi F Gazdar; D J Venzon; Seth M Steinberg; Robert L Dedrick; James L Mulshine; B S Kramer
Lack of in vitro synergy between etoposide and cis-diamminedichloroplatinum(II).
Cancer research 1989;49(9):2390-7.
1989: L J Goldstein; H Galski; Antonio Tito Fojo; M Willingham; S L Lai; Adi F Gazdar; Robert Pirker; A Green; William M Crist; G M Brodeur
Expression of a multidrug resistance gene in human cancers.
Journal of the National Cancer Institute 1989;81(2):116-24.
1989: John D Minna; J Schütte; J Viallet; F Thomas; Frederic J Kaye; T Takahashi; Marion M Nau; J Whang-Peng; Michael J Birrer; Adi F Gazdar
Transcription factors and recessive oncogenes in the pathogenesis of human lung cancer.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1989;4():32-4.
1988: J G Park; J M Collins; Adi F Gazdar; Carmen J Allegra; S M Steinberg; R F Greene; B S Kramer
Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines.
Journal of the National Cancer Institute 1988;80(19):1560-4.
1988: RI Linnoila; James L Mulshine; Seth M Steinberg; K Funa; M J Matthews; J D Cotelingam; Adi F Gazdar
Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas.
American journal of clinical pathology 1988;90(6):641-52.
1988: Bruce E Johnson; R W Makuch; A D Simmons; Adi F Gazdar; D Burch; A W Cashell
myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines.
Cancer research 1988;48(18):5163-6.
1988: Lee Helman; Adi F Gazdar; J G Park; P S Cohen; J D Cotelingam; Mark Israel
Chromogranin A expression in normal and malignant human tissues.
The Journal of clinical investigation 1988;82(2):686-90.
1988: Bruce E Johnson; A Y Sakaguchi; Adi F Gazdar; John D Minna; D Burch; A Marshall; Susan Naylor
Restriction fragment length polymorphism studies show consistent loss of chromosome 3p alleles in small cell lung cancer patients' tumors.
The Journal of clinical investigation 1988;82(2):502-7.
1988: Adi F Gazdar; Lee Helman; Mark Israel; E K Russell; RI Linnoila; James L Mulshine; H M Schuller; J G Park
Expression of neuroendocrine cell markers L-dopa decarboxylase, chromogranin A, and dense core granules in human tumors of endocrine and nonendocrine origin.
Cancer research 1988;48(14):4078-82.
1988: J. William Harbour; S L Lai; J Whang-Peng; Adi F Gazdar; J D Minna; Frederic J Kaye
Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.
Science (New York, N.Y.) 1988;241(4863):353-7.
1988: Y Nakanishi; James L Mulshine; P G Kasprzyk; R B Natale; R Maneckjee; Ingalill Avis; AM Treston; Adi F Gazdar; John D Minna; Frank Cuttitta
Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.
The Journal of clinical investigation 1988;82(1):354-9.
1988: J Gu; R I Linnoila; Nita L Seibel; Adi F Gazdar; John D Minna; B J Brooks; G F Hollis; Ilan R Kirsch
A study of myc-related gene expression in small cell lung cancer by in situ hybridization.
The American journal of pathology 1988;132(1):13-7.
1988: J Carmichael; J B Mitchell; William DeGraff; Janet Gamson; Adi F Gazdar; Bruce E Johnson; E Glatstein; John D Minna
Chemosensitivity testing of human lung cancer cell lines using the MTT assay.
British journal of cancer 1988;57(6):540-7.
1988: Adi F Gazdar; R I Linnoila
The pathology of lung cancer--changing concepts and newer diagnostic techniques.
Seminars in oncology 1988;15(3):215-25.
1988: Y Nakanishi; Frank Cuttitta; P G Kasprzyk; Ingalill Avis; S M Steinberg; Adi F Gazdar; James L Mulshine
Growth factor effects on small cell lung cancer cells using a colorimetric assay: can a transferrin-like factor mediate autocrine growth?
Experimental cell biology 1988;56(1-2):74-85.
1987: J G Park; H K Oie; P H Sugarbaker; J G Henslee; T R Chen; Bruce E Johnson; Adi F Gazdar
Characteristics of cell lines established from human colorectal carcinoma.
Cancer research 1987;47(24 Pt 1):6710-8.
1987: J G Park; B S Kramer; Seth M Steinberg; J Carmichael; J M Collins; John D Minna; Adi F Gazdar
Chemosensitivity testing of human colorectal carcinoma cell lines using a tetrazolium-based colorimetric assay.
Cancer research 1987;47(22):5875-9.
1987: J Whang-Peng; C E Freter; Turid Knutsen; J J Nanfro; Adi F Gazdar
Translocation t(11;22) in esthesioneuroblastoma.
Cancer genetics and cytogenetics 1987;29(1):155-7.
1987: John Ruckdeschel; D N Carney; H K Oie; E K Russell; Adi F Gazdar
In vitro chemosensitivity of human lung cancer cell lines.
Cancer treatment reports 1987;71(7-8):697-704.
1986: S Fargion; D Carney; J Mulshine; S Rosen; P Bunn; P Jewett; F Cuttitta; Adi F Gazdar; J Minna
Heterogeneity of cell surface antigen expression of human small cell lung cancer detected by monoclonal antibodies.
Cancer research 1986;46(5):2633-8.
1986: Marion M Nau; B J Brooks; D N Carney; Adi F Gazdar; James F Battey; Edward A Sausville; John D Minna
Human small-cell lung cancers show amplification and expression of the N-myc gene.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):1092-6.
1986: John D Minna; James F Battey; B J Brooks; Frank Cuttitta; Adi F Gazdar; Bruce E Johnson; D C Ihde; A M Lebacq-Verheyden; J Mulshine; Marion M Nau
Molecular genetic analysis reveals chromosomal deletion, gene amplification, and autocrine growth factor production in the pathogenesis of human lung cancer.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():843-53.
1986: John D Minna; James F Battey; Michael J Birrer; B J Brooks; Frank Cuttitta; J DeGreve; Adi F Gazdar; Bruce E Johnson; Marion M Nau; Edward A Sausville
Chromosomal deletion, gene amplification, alternative processing, and autocrine growth factor production in the pathogenesis of human lung cancer.
Princess Takamatsu symposia 1986;17():109-22.
1985: Marion M Nau; B J Brooks; J Battey; Edward A Sausville; Adi F Gazdar; Ilan R Kirsch; O W McBride; VL Bertness; G F Hollis; John D Minna
L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer.
Nature 1985;318(6041):69-73.
1985: P A Bunn; I Linnoila; J D Minna; D Carney; Adi F Gazdar
Small cell lung cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express the Leu-7 antigenic determinant present on natural killer cells.
Blood 1985;65(3):764-8.
1971: N Talal; A D Steinberg; M E Jacobs; T M Chused; Adi F Gazdar
Immune cell cooperation, viruses, and antibodies to nucleic acids in new zealand mice.
The Journal of experimental medicine 1971;134(3):52-64.