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Adi Gazdar

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Konstantinidou Georgia; Bey Erik A; Rabellino Andrea; Schuster Katja; Maira Michael S; Gazdar Adi F; Amici Augusto; Boothman David A; Scaglioni Pier Paolo
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Gazdar Adi F
Personalized medicine and inhibition of EGFR signaling in lung cancer.
Gazdar A F
Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors.

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All Publications

2009: Konstantinidou Georgia; Bey Erik A; Rabellino Andrea; Schuster Katja; Maira Michael S; Gazdar Adi F; Amici Augusto; Boothman David A; Scaglioni Pier Paolo
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Cancer research 2009;69(19):7644-52.
2009: Gazdar Adi F
Personalized medicine and inhibition of EGFR signaling in lung cancer.
The New England journal of medicine 2009;361(10):1018-20.
2009: Gazdar A F
Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors.
Oncogene 2009;28 Suppl 1():S24-31.
2009: Lee Pyng; van den Berg Remco M; Lam Stephen; Gazdar Adi F; Grunberg Katrien; McWilliams Annette; Leriche Jean; Postmus Pieter E; Sutedja Tom G
Color fluorescence ratio for detection of bronchial dysplasia and carcinoma in situ.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(14):4700-5.
2009: Gazdar Adi F; Minna John D
Multifocal lung cancers--clonality vs field cancerization and does it matter?
Journal of the National Cancer Institute 2009;101(8):541-3.
2009: Sos Martin L; Koker Mirjam; Weir Barbara A; Heynck Stefanie; Rabinovsky Rosalia; Zander Thomas; Seeger Jens M; Weiss Jonathan; Fischer Florian; Frommolt Peter; Michel Kathrin; Peifer Martin; Mermel Craig; Girard Luc; Peyton Michael; Gazdar Adi F; Minna John D; Garraway Levi A; Kashkar Hamid; Pao William; Meyerson Matthew; Thomas Roman K
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR.
Cancer research 2009;69(8):3256-61.
2009: Kubo Takafumi; Yamamoto Hiromasa; Lockwood William W; Valencia Ilse; Soh Junichi; Peyton Michael; Jida Masaru; Otani Hiroki; Fujii Tetsuya; Ouchida Mamoru; Takigawa Nagio; Kiura Katsuyuki; Shimizu Kenji; Date Hiroshi; Minna John D; Varella-Garcia Marileila; Lam Wan L; Gazdar Adi F; Toyooka Shinichi
MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors.
International journal of cancer. Journal international du cancer 2009;124(8):1778-84.
2009: Zhang Wei; Peyton Michael; Xie Yang; Soh Junichi; Minna John D; Gazdar Adi F; Frenkel Eugene P
Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(2):161-6.
2009: Soh Junichi; Okumura Naoki; Lockwood William W; Yamamoto Hiromasa; Shigematsu Hisayuki; Zhang Wei; Chari Raj; Shames David S; Tang Ximing; MacAulay Calum; Varella-Garcia Marileila; Vooder Tõnu; Wistuba Ignacio I; Lam Stephen; Brekken Rolf; Toyooka Shinichi; Minna John D; Lam Wan L; Gazdar Adi F
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
PloS one 2009;4(10):e7464.
2009: Kao Jessica; Salari Keyan; Bocanegra Melanie; Choi Yoon-La; Girard Luc; Gandhi Jeet; Kwei Kevin A; Hernandez-Boussard Tina; Wang Pei; Gazdar Adi F; Minna John D; Pollack Jonathan R
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PloS one 2009;4(7):e6146.
2009: Gandhi Jeet; Zhang Jianling; Xie Yang; Soh Junichi; Shigematsu Hisayuki; Zhang Wei; Yamamoto Hiromasa; Peyton Michael; Girard Luc; Lockwood William W; Lam Wan L; Varella-Garcia Marileila; Minna John D; Gazdar Adi F
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
PloS one 2009;4(2):e4576.
2009: Miura Norimasa; Sato Reina; Tsukamoto Tomoe; Shimizu Mika; Kabashima Hiroko; Takeda Miho; Takahashi Shunsaku; Harada Tomomi; West James E; Drabkin Harry; Mejia Jose E; Shiota Goshi; Murawaki Yoshikazu; Virmani Arvind; Gazdar Adi F; Oshimura Mitsuo; Hasegawa Junichi
A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT.
BMC molecular biology 2009;10():5.
2008: Shivapurkar Narayan; Stastny Victor; Okumura Naoki; Girard Luc; Xie Yang; Prinsen Clemens; Thunnissen Frederik B; Wistuba Ignacio I; Czerniak Bogdan; Frenkel Eugene; Roth Jack A; Liloglou Triantafillos; Xinarianos George; Field John K; Minna John D; Gazdar Adi F
Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.
Cancer research 2008;68(18):7448-56.
2008: Yamamoto Hiromasa; Shigematsu Hisayuki; Nomura Masaharu; Lockwood William W; Sato Mitsuo; Okumura Naoki; Soh Junichi; Suzuki Makoto; Wistuba Ignacio I; Fong Kwun M; Lee Huei; Toyooka Shinichi; Date Hiroshi; Lam Wan L; Minna John D; Gazdar Adi F
PIK3CA mutations and copy number gains in human lung cancers.
Cancer research 2008;68(17):6913-21.
2008: Gazdar Adi F; Minna John D
Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops.
Cancer prevention research (Philadelphia, Pa.) 2008;1(3):156-60.
2008: Toyooka Shinichi; Matsuo Keitaro; Gazdar Adi F
DNA methylation in lung cancer.
The New England journal of medicine 2008;358(23):2513; author reply 2514.
2008: Shivapurkar Narayan; Stastny Victor; Xie Yang; Prinsen Clemens; Frenkel Eugene; Czerniak Bogdan; Thunnissen Frederik B; Minna John D; Gazdar Adi F
Differential methylation of a short CpG-rich sequence within exon 1 of TCF21 gene: a promising cancer biomarker assay.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(4):995-1000.
2008: Soh Junichi; Toyooka Shinichi; Ichihara Shuji; Asano Hiroaki; Kobayashi Naruyuki; Suehisa Hiroshi; Otani Hiroki; Yamamoto Hiromasa; Ichimura Kouichi; Kiura Katsuyuki; Gazdar Adi F; Date Hiroshi
Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(4):340-7.
2008: Eckstein Niels; Servan Kati; Girard Luc; Cai Di; von Jonquieres Georg; Jaehde Ulrich; Kassack Matthias U; Gazdar Adi F; Minna John D; Royer Hans-Dieter
Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells.
The Journal of biological chemistry 2008;283(2):739-50.
2007: Bean James; Brennan Cameron; Shih Jin-Yuan; Riely Gregory; Viale Agnes; Wang Lu; Chitale Dhananjay; Motoi Noriko; Szoke Janos; Broderick Stephen; Balak Marissa; Chang Wen-Cheng; Yu Chong-Jen; Gazdar Adi; Pass Harvey; Rusch Valerie; Gerald William; Huang Shiu-Feng; Yang Pan-Chyr; Miller Vincent; Ladanyi Marc; Yang Chih-Hsin; Pao William
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20932-7.
2007: Shivapurkar Narayan; Sherman Mark E; Stastny Victor; Echebiri Chinyere; Rader Janet S; Nayar Ritu; Bonfiglio Thomas A; Gazdar Adi F; Wang Sophia S
Evaluation of candidate methylation markers to detect cervical neoplasia.
Gynecologic oncology 2007;107(3):549-53.
2007: Suzuki Makoto; Shigematsu Hisayuki; Nakajima Takahiro; Kubo Rieko; Motohashi Shinichiro; Sekine Yasuo; Shibuya Kiyoshi; Iizasa Toshihiko; Hiroshima Kenzo; Nakatani Yukio; Gazdar Adi F; Fujisawa Takehiko
Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(20):6087-92.
2007: Toyooka Shinichi; Matsuo Keitaro; Shigematsu Hisayuki; Kosaka Takayuki; Tokumo Masaki; Yatabe Yasushi; Ichihara Syuji; Inukai Michio; Suehisa Hiroshi; Soh Junichi; Kiura Katsuyuki; Fong Kwun M; Lee Huei; Wistuba Ignacio I; Gazdar Adi F; Mitsudomi Tetsuya; Date Hiroshi
The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5763-8.
2007: Sun Sophie; Schiller Joan H; Gazdar Adi F
Lung cancer in never smokers--a different disease.
Nature reviews. Cancer 2007;7(10):778-90.
2007: Kennedy Timothy C; McWilliams Annette; Edell Eric; Sutedja Tom; Downie Gordon; Yung Rex; Gazdar Adi; Mathur Praveen N;
Bronchial intraepithelial neoplasia/early central airways lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition).
Chest 2007;132(3 Suppl):221S-233S.
2007: Chen Yuanbin; De Marco Melissa A; Graziani Irene; Gazdar Adi F; Strack Peter R; Miele Lucio; Bocchetta Maurizio
Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung.
Cancer research 2007;67(17):7954-9.
2007: Padrón David; Sato Mitsuo; Shay Jerry W; Gazdar Adi F; Minna John D; Roth Michael G
Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized.
Cancer research 2007;67(16):7695-702.
2007: Shames David S; Minna John D; Gazdar Adi F
Methods for detecting DNA methylation in tumors: from bench to bedside.
Cancer letters 2007;251(2):187-98.
2007: Vikis Haris; Sato Mitsuo; James Michael; Wang Daolong; Wang Yian; Wang Min; Jia Dongmei; Liu Yan; Bailey-Wilson Joan E; Amos Christopher I; Pinney Susan M; Petersen Gloria M; de Andrade Mariza; Yang Ping; Wiest Jonathan S; Fain Pamela R; Schwartz Ann G; Gazdar Adi; Gaba Colette; Rothschild Henry; Mandal Diptasri; Kupert Elena; Seminara Daniela; Viswanathan Avinash; Govindan Ramaswamy; Minna John; Anderson Marshall W; You Ming
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity.
Cancer research 2007;67(10):4665-70.
2007: Lam David Chi-Leung; Girard Luc; Ramirez Ruben; Chau Wing-Shun; Suen Wai-sing; Sheridan Shelley; Tin Vicky P C; Chung Lap-ping; Wong Maria P; Shay Jerry W; Gazdar Adi F; Lam Wah-kit; Minna John D
Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers.
Cancer research 2007;67(10):4638-47.
2007: Carter Darryl; Vazquez Madeline; Flieder Douglas B; Brambilla Elizabeth; Gazdar Adi; Noguchi Masayuki; Travis William D; Kramer Arin; Yip Rowena; Yankelevitz David F; Henschke Claudia I;
Comparison of pathologic findings of baseline and annual repeat cancers diagnosed on CT screening.
Lung cancer (Amsterdam, Netherlands) 2007;56(2):193-9.
2007: Nomura Masaharu; Shigematsu Hisayuki; Li Lin; Suzuki Makoto; Takahashi Takao; Estess Pila; Siegelman Mark; Feng Ziding; Kato Harubumi; Marchetti Antonio; Shay Jerry W; Spitz Margaret R; Wistuba Ignacio I; Minna John D; Gazdar Adi F
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.
PLoS medicine 2007;4(4):e125.
2007: Sato Mitsuo; Shames David S; Gazdar Adi F; Minna John D
A translational view of the molecular pathogenesis of lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2007;2(4):327-43.
2007: Hirsch F R; Varella-Garcia M; Cappuzzo F; McCoy J; Bemis L; Xavier A C; Dziadziuszko R; Gumerlock P; Chansky K; West H; Gazdar A F; Crino L; Gandara D R; Franklin W A; Bunn P A
Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(4):752-60.
2007: Suzuki Makoto; Shigematsu Hisayuki; Shames David S; Sunaga Noriaki; Takahashi Takao; Shivapurkar Narayan; Iizasa Toshihiko; Minna John D; Fujisawa Takehiko; Gazdar Adi F
Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers.
Annals of surgical oncology 2007;14(4):1397-404.
2007: Shivapurkar Narayan; Stastny Victor; Suzuki Makoto; Wistuba Ignacio I; Li Lin; Zheng Yingye; Feng Ziding; Hol Bernard; Prinsen Clemens; Thunnissen Frederik B; Gazdar Adi F
Application of a methylation gene panel by quantitative PCR for lung cancers.
Cancer letters 2007;247(1):56-71.
2007: Gazdar Adi F
DNA repair and survival in lung cancer--the two faces of Janus.
The New England journal of medicine 2007;356(8):771-3.
2007: Shames David S; Minna John D; Gazdar Adi F
DNA methylation in health, disease, and cancer.
Current molecular medicine 2007;7(1):85-102.
2007: Gazdar Adi F; Thun Michael J
Lung cancer, smoke exposure, and sex.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(5):469-71.
2007: Wang Min; Vikis Haris G; Wang Yian; Jia Dongmei; Wang Daolong; Bierut Laura J; Bailey-Wilson Joan E; Amos Christopher I; Pinney Susan M; Petersen Gloria M; de Andrade Mariza; Yang Ping; Wiest Jonathan S; Fain Pamela R; Schwartz Ann G; Gazdar Adi; Minna John; Gaba Colette; Rothschild Henry; Mandal Diptasri; Kupert Elena; Seminara Daniela; Liu Yan; Viswanathan Avinash; Govindan Ramaswamy; Anderson Marshall W; You Ming
Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1.
Cancer research 2007;67(1):93-9.
2007: Sathyanarayana Ubaradka G; Moore Angela Yen; Li Lin; Padar Asha; Majmudar Kuntal; Stastny Victor; Makarla Prakash; Suzuki Makoto; Minna John D; Feng Ziding; Gazdar Adi F
Sun exposure related methylation in malignant and non-malignant skin lesions.
Cancer letters 2007;245(1-2):112-20.
2006: Shames David S; Girard Luc; Gao Boning; Sato Mitsuo; Lewis Cheryl M; Shivapurkar Narayan; Jiang Aixiang; Perou Charles M; Kim Young H; Pollack Jonathan R; Fong Kwun M; Lam Chi-Leung; Wong Maria; Shyr Yu; Nanda Rita; Olopade Olufunmilayo I; Gerald William; Euhus David M; Shay Jerry W; Gazdar Adi F; Minna John D
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies.
PLoS medicine 2006;3(12):e486.
2006: Neve Richard M; Chin Koei; Fridlyand Jane; Yeh Jennifer; Baehner Frederick L; Fevr Tea; Clark Laura; Bayani Nora; Coppe Jean-Philippe; Tong Frances; Speed Terry; Spellman Paul T; DeVries Sandy; Lapuk Anna; Wang Nick J; Kuo Wen-Lin; Stilwell Jackie L; Pinkel Daniel; Albertson Donna G; Waldman Frederic M; McCormick Frank; Dickson Robert B; Johnson Michael D; Lippman Marc; Ethier Stephen; Gazdar Adi; Gray Joe W
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer cell 2006;10(6):515-27.
2006: Helfrich Barbara A; Raben David; Varella-Garcia Marileila; Gustafson Dan; Chan Daniel C; Bemis Lynne; Coldren Chris; Barón Anna; Zeng Chan; Franklin Wilbur A; Hirsch Fred R; Gazdar Adi; Minna John; Bunn Paul A
Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(23):7117-25.
2006: Das Amit K; Sato Mitsuo; Story Michael D; Peyton Michael; Graves Robert; Redpath Stella; Girard Luc; Gazdar Adi F; Shay Jerry W; Minna John D; Nirodi Chaitanya S
Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation.
Cancer research 2006;66(19):9601-8.
2006: Sjöblom Tobias; Jones Siân; Wood Laura D; Parsons D Williams; Lin Jimmy; Barber Thomas D; Mandelker Diana; Leary Rebecca J; Ptak Janine; Silliman Natalie; Szabo Steve; Buckhaults Phillip; Farrell Christopher; Meeh Paul; Markowitz Sanford D; Willis Joseph; Dawson Dawn; Willson James K V; Gazdar Adi F; Hartigan James; Wu Leo; Liu Changsheng; Parmigiani Giovanni; Park Ben Ho; Bachman Kurtis E; Papadopoulos Nickolas; Vogelstein Bert; Kinzler Kenneth W; Velculescu Victor E
The consensus coding sequences of human breast and colorectal cancers.
Science (New York, N.Y.) 2006;314(5797):268-74.
2006: Wood Laura D; Calhoun Eric S; Silliman Natalie; Ptak Janine; Szabo Steve; Powell Steve M; Riggins Gregory J; Wang Tian-Li; Yan Hai; Gazdar Adi; Kern Scott E; Pennacchio Len; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
Human mutation 2006;27(10):1060-1.
2006: Suzuki Makoto; Shigematsu Hisayuki; Shivapurkar Narayan; Reddy Jyotsna; Miyajima Kuniharu; Takahashi Takao; Gazdar Adi F; Frenkel Eugene P
Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer.
Cancer letters 2006;242(2):222-30.
2006: Zhou Bin-Bing S; Peyton Michael; He Biao; Liu Changnian; Girard Luc; Caudler Eian; Lo Yvonne; Baribaud Frederic; Mikami Iwao; Reguart Noemi; Yang Gengjie; Li Yanlong; Yao Wenqing; Vaddi Kris; Gazdar Adi F; Friedman Steven M; Jablons David M; Newton Robert C; Fridman Jordan S; Minna John D; Scherle Peggy A
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.
Cancer cell 2006;10(1):39-50.
2006: Wang Shizhen Emily; Narasanna Archana; Perez-Torres Marianela; Xiang Bin; Wu Frederick Y; Yang Seungchan; Carpenter Graham; Gazdar Adi F; Muthuswamy Senthil K; Arteaga Carlos L
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
Cancer cell 2006;10(1):25-38.
2006: Coe B P; Lockwood W W; Girard L; Chari R; Macaulay C; Lam S; Gazdar A F; Minna J D; Lam W L
Differential disruption of cell cycle pathways in small cell and non-small cell lung cancer.
British journal of cancer 2006;94(12):1927-35.
2006: Flieder Douglas B; Vazquez Madeline; Carter Darryl; Brambilla Elizabeth; Gazdar Adi; Noguchi Masayuki; Travis William D; Kramer Arin; Yankelevitz David F; Henschke Claudia I
Pathologic findings of lung tumors diagnosed on baseline CT screening.
The American journal of surgical pathology 2006;30(5):606-13.
2006: Suzuki Makoto; Shigematsu Hisayuki; Iizasa Toshihiko; Hiroshima Kenzo; Nakatani Yukio; Minna John D; Gazdar Adi F; Fujisawa Takehiko
Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer.
Cancer 2006;106(10):2200-7.
2006: Aoe Keisuke; Hiraki Akio; Murakami Tomoyuki; Toyooka Shinichi; Shivapurkar Narayan; Gazdar Adi F; Sueoka Naoko; Taguchi Koji; Kamei Toshiaki; Takeyama Hiroyasu; Sugi Kazuro; Kishimoto Takumi
Infrequent existence of simian virus 40 large T antigen DNA in malignant mesothelioma in Japan.
Cancer science 2006;97(4):292-5.
2006: Tsao Anne S; Tang Xi Ming; Sabloff Bradley; Xiao Lianchun; Shigematsu Hisayuki; Roth Jack; Spitz Margaret; Hong Waun Ki; Gazdar Adi; Wistuba Ignacio
Clinicopathologic characteristics of the EGFR gene mutation in non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(3):231-9.
2006: Tam Issan Yee San; Chung Lap Ping; Suen Wai Sing; Wang Elaine; Wong May C M; Ho Kok Keung; Lam Wah Kit; Chiu Shui Wah; Girard Luc; Minna John D; Gazdar Adi F; Wong Maria P
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1647-53.
2006: Garnis Cathie; Lockwood William W; Vucic Emily; Ge Yong; Girard Luc; Minna John D; Gazdar Adi F; Lam Stephen; MacAulay Calum; Lam Wan L
High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.
International journal of cancer. Journal international du cancer 2006;118(6):1556-64.
2006: Sato Mitsuo; Vaughan Melville B; Girard Luc; Peyton Michael; Lee Woochang; Shames David S; Ramirez Ruben D; Sunaga Noriaki; Gazdar Adi F; Shay Jerry W; Minna John D
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.
Cancer research 2006;66(4):2116-28.
2006: Toyooka Shinichi; Tokumo Masaki; Shigematsu Hisayuki; Matsuo Keitaro; Asano Hiroaki; Tomii Kunitoshi; Ichihara Shuji; Suzuki Makoto; Aoe Motoi; Date Hiroshi; Gazdar Adi F; Shimizu Nobuyoshi
Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.
Cancer research 2006;66(3):1371-5.
2006: Kim Mi-Sook; Jeong Joon; Majewski Tadeusz; Kram Andrzej; Yoon Dong-Sup; Zhang Ruo-Dan; Li Jun-Zhi; Ptaszynski Konrad; Kuang Tang C; Zhou Jain-Hua; Sathyanarayana Ubaradka G; Tuziak Tomasz; Johnston Dennis A; Grossman Herbert B; Gazdar Adi F; Scherer Steven E; Benedict William F; Czerniak Bogdan
Evidence for alternative candidate genes near RB1 involved in clonal expansion of in situ urothelial neoplasia.
Laboratory investigation; a journal of technical methods and pathology 2006;86(2):175-90.
2006: Heller Gerwin; Fong Kwun M; Girard Luc; Seidl Sonja; End-Pfützenreuter Adelheid; Lang György; Gazdar Adi F; Minna John D; Zielinski Christoph C; Zöchbauer-Müller Sabine
Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas.
Oncogene 2006;25(6):959-68.
2006: Takahashi Takao; Shigematsu Hisayuki; Shivapurkar Narayan; Reddy Jyotsna; Zheng Yingye; Feng Ziding; Suzuki Makoto; Nomura Masaharu; Augustus Meena; Yin Jing; Meltzer Stephen J; Gazdar Adi F
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.
International journal of cancer. Journal international du cancer 2006;118(4):924-31.
2006: Gazdar Adi F
Rapid screening for EGFR mutations: pros and cons.
Cancer journal (Sudbury, Mass.) 2006;12(1):17-8.
2006: Witta Samir E; Gemmill Robert M; Hirsch Fred R; Coldren Christopher D; Hedman Karla; Ravdel Larisa; Helfrich Barbara; Dziadziuszko Rafal; Chan Daniel C; Sugita Michio; Chan Zeng; Baron Anna; Franklin Wilbur; Drabkin Harry A; Girard Luc; Gazdar Adi F; Minna John D; Bunn Paul A
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.
Cancer research 2006;66(2):944-50.
2006: Shigematsu Hisayuki; Gazdar Adi F
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers.
International journal of cancer. Journal international du cancer 2006;118(2):257-62.
2006: Coe Bradley P; Lee Eric H L; Chi Bryan; Girard Luc; Minna John D; Gazdar Adi F; Lam Stephen; MacAulay Calum; Lam Wan L
Gain of a region on 7p22.3, containing MAD1L1, is the most frequent event in small-cell lung cancer cell lines.
Genes, chromosomes & cancer 2006;45(1):11-9.
2006: Wistuba Ignacio I; Gazdar Adi F
Lung cancer preneoplasia.
Annual review of pathology 2006;1():331-48.
2005: Gazdar Adi F; Minna John D
Inhibition of EGFR signaling: all mutations are not created equal.
PLoS medicine 2005;2(11):e377.
2005: Suzuki M; Shigematsu H; Shames D S; Sunaga N; Takahashi T; Shivapurkar N; Iizasa T; Frenkel E P; Minna J D; Fujisawa T; Gazdar A F
DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers.
British journal of cancer 2005;93(9):1029-37.
2005: Suzuki Makoto; Shigematsu Hisayuki; Hiroshima Kenzo; Iizasa Toshihiko; Nakatani Yukio; Minna John D; Gazdar Adi F; Fujisawa Takehiko
Epidermal growth factor receptor expression status in lung cancer correlates with its mutation.
Human pathology 2005;36(10):1127-34.
2005: Maitra Anirban; Arking Dan E; Shivapurkar Narayan; Ikeda Morna; Stastny Victor; Kassauei Keyaunoosh; Sui Guoping; Cutler David J; Liu Ying; Brimble Sandii N; Noaksson Karin; Hyllner Johan; Schulz Thomas C; Zeng Xianmin; Freed William J; Crook Jeremy; Abraham Suman; Colman Alan; Sartipy Peter; Matsui Sei-Ichi; Carpenter Melissa; Gazdar Adi F; Rao Mahendra; Chakravarti Aravinda
Genomic alterations in cultured human embryonic stem cells.
Nature genetics 2005;37(10):1099-103.
2005: Tang Ximing; Shigematsu Hisayuki; Bekele B Nebiyou; Roth Jack A; Minna John D; Hong Waun Ki; Gazdar Adi F; Wistuba Ignacio I
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients.
Cancer research 2005;65(17):7568-72.
2005: Zöchbauer-Müller Sabine; Fong Kwun M; Geradts Joseph; Xu Xie; Seidl Sonja; End-Pfützenreuter Adelheid; Lang György; Heller Gerwin; Zielinski Christoph C; Gazdar Adi F; Minna John D
Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation.
Oncogene 2005;24(41):6249-55.
2005: Shivapurkar Narayan; Stastny Victor; Takahashi Takao; Suzuki Makoto; Echebiri Chinyere; Reddy Jyotsna; Gazdar Adi F
Novel real-time PCR assay using a universal molecular marker for diagnosis of hematologic cancers.
International journal of cancer. Journal international du cancer 2005;116(4):656-60.
2005: Minna John D; Peyton Michael J; Gazdar Adi F
Gefitinib versus cetuximab in lung cancer: round one.
Journal of the National Cancer Institute 2005;97(16):1168-9.
2005: Makarla Prakash B; Saboorian M Hossein; Ashfaq Raheela; Toyooka Kiyomi O; Toyooka Shinichi; Minna John D; Gazdar Adi F; Schorge John O
Promoter hypermethylation profile of ovarian epithelial neoplasms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5365-9.
2005: Cappuzzo Federico; Varella-Garcia Marileila; Shigematsu Hisayuki; Domenichini Irene; Bartolini Stefania; Ceresoli Giovanni L; Rossi Elisa; Ludovini Vienna; Gregorc Vanesa; Toschi Luca; Franklin Wilbur A; Crino Lucio; Gazdar Adi F; Bunn Paul A; Hirsch Fred R
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(22):5007-18.
2005: Moreno Mauricio; Pimentel Fernando; Gazdar Adi F; Wistuba Ignacio I; Miquel Juan F
TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma.
Annals of hepatology : official journal of the Mexican Association of Hepatology 2005;4(3):192-9.
2005: Takahashi Takao; Suzuki Makoto; Shigematsu Hisayuki; Shivapurkar Narayan; Echebiri Chinyere; Nomura Masaharu; Stastny Victor; Augustus Meena; Wu Chew-Wun; Wistuba Ignacio I; Meltzer Stephen J; Gazdar Adi F
Aberrant methylation of Reprimo in human malignancies.
International journal of cancer. Journal international du cancer 2005;115(4):503-10.
2005: López José I; Colby Thomas V; Gazdar Adi F
Current status of small peripheral adenocarcinomas of the lung and their importance to pathologists.
Annals of diagnostic pathology 2005;9(2):115-22.
2005: Henderson L-J; Coe B P; Lee E H L; Girard L; Gazdar A F; Minna J D; Lam S; MacAulay C; Lam W L
Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small-cell lung carcinoma cells.
British journal of cancer 2005;92(8):1553-60.
2005: Sekine Ikuo; Sato Mitsuo; Sunaga Noriaki; Toyooka Shinichi; Peyton Michael; Parsons Ramon; Wang Weidong; Gazdar Adi F; Minna John D
The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer.
Oncogene 2005;24(16):2735-8.
2005: Jakob John; Nagase Satoru; Gazdar Adi; Chien Minchen; Morozova Irina; Russo James J; Nandula Subhadra V; Murty Vundavalli V V S; Li Chi-Ming; Tycko Benjamin; Parsons Ramon
Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line.
Genes, chromosomes & cancer 2005;42(4):372-83.
2005: Dote H; Toyooka S; Tsukuda K; Yano M; Ota T; Murakami M; Naito M; Toyota M; Gazdar A F; Shimizu N
Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour.
British journal of cancer 2005;92(6):1117-25.
2005: Suzuki M; Hao C; Takahashi T; Shigematsu H; Shivapurkar N; Sathyanarayana U G; Iizasa T; Fujisawa T; Hiroshima K; Gazdar A F
Aberrant methylation of SPARC in human lung cancers.
British journal of cancer 2005;92(5):942-8.
2005: Shigematsu Hisayuki; Takahashi Takao; Nomura Masaharu; Majmudar Kuntal; Suzuki Makoto; Lee Huei; Wistuba Ignacio I; Fong Kwun M; Toyooka Shinichi; Shimizu Nobuyoshi; Fujisawa Takehiko; Minna John D; Gazdar Adi F
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.
Cancer research 2005;65(5):1642-6.
2005: Shigematsu Hisayuki; Lin Li; Takahashi Takao; Nomura Masaharu; Suzuki Makoto; Wistuba Ignacio I; Fong Kwun M; Lee Huei; Toyooka Shinichi; Shimizu Nobuyoshi; Fujisawa Takehiko; Feng Ziding; Roth Jack A; Herz Joachim; Minna John D; Gazdar Adi F
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
Journal of the National Cancer Institute 2005;97(5):339-46.
2005: Suzuki Makoto; Shigematsu Hisayuki; Takahashi Takao; Shivapurkar Narayan; Sathyanarayana Ubaradka G; Iizasa Toshihiko; Fujisawa Takehiko; Gazdar Adi F
Aberrant methylation of Reprimo in lung cancer.
Lung cancer (Amsterdam, Netherlands) 2005;47(3):309-14.
2005: Coe Bradley P; Henderson Laura-Jane; Garnis Cathie; Tsao Ming-Sound; Gazdar Adi F; Minna John; Lam Stephen; Macaulay Calum; Lam Wan L
High-resolution chromosome arm 5p array CGH analysis of small cell lung carcinoma cell lines.
Genes, chromosomes & cancer 2005;42(3):308-13.
2005: Tokumo Masaki; Toyooka Shinichi; Kiura Katsuyuki; Shigematsu Hisayuki; Tomii Kunitoshi; Aoe Motoi; Ichimura Kouichi; Tsuda Toshihide; Yano Masaaki; Tsukuda Kazunori; Tabata Masahiro; Ueoka Hiroshi; Tanimoto Mitsune; Date Hiroshi; Gazdar Adi F; Shimizu Nobuyoshi
The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1167-73.
2005: Suzuki Makoto; Toyooka Shinichi; Shivapurkar Narayan; Shigematsu Hisayuki; Miyajima Kuniharu; Takahashi Takao; Stastny Victor; Zern Andrea L; Fujisawa Takehiko; Pass Harvey I; Carbone Michele; Gazdar Adi F
Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection.
Oncogene 2005;24(7):1302-8.
2005: Shigematsu Hisayuki; Suzuki Makoto; Takahashi Takao; Miyajima Kuniharu; Toyooka Shinichi; Shivapurkar Narayan; Tomlinson Gail E; Mastrangelo Domenico; Pass Harvey I; Brambilla Elisabeth; Sathyanarayana Ubaradka G; Czerniak Bogdan; Fujisawa Takehiko; Shimizu Nobuyoshi; Gazdar Adi F
Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies.
International journal of cancer. Journal international du cancer 2005;113(4):600-4.
2005: Amann Joseph; Kalyankrishna Shailaja; Massion Pierre P; Ohm Joyce E; Girard Luc; Shigematsu Hisayuki; Peyton Michael; Juroske Denise; Huang Yuhui; Stuart Salmon J; Kim Young H; Pollack Jonathan R; Yanagisawa Kiyoshi; Gazdar Adi; Minna John D; Kurie Jonathan M; Carbone David P
Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer.
Cancer research 2005;65(1):226-35.
2005: Reddy Jyotsna; Shivapurkar Narayan; Takahashi Takao; Parikh Gunjan; Stastny Victor; Echebiri Chinyere; Crumrine Katherine; Zöchbauer-Müller Sabine; Drach Johannes; Zheng Yingye; Feng Ziding; Kroft Steven H; McKenna Robert W; Gazdar Adi F
Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors.
Oncogene 2005;24(4):732-6.
2005: Yano Masaaki; Toyooka Shinichi; Tsukuda Kazunori; Dote Hideaki; Ouchida Mamoru; Hanabata Tetsuro; Aoe Motoi; Date Hiroshi; Gazdar Adi F; Shimizu Nobuyoshi
Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers.
International journal of cancer. Journal international du cancer 2005;113(1):59-66.
2005: Guillaud Martial; le Riche Jean C; Dawe Chris; Korbelik Jagoda; Coldman Andy; Wistuba Ignacio I; Park In-Won; Gazdar Adi; Lam Stephen; MacAulay Calum E
Nuclear morphometry as a biomarker for bronchial intraepithelial neoplasia: correlation with genetic damage and cancer development.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;63(1):34-40.
2004: Ramirez Ruben D; Sheridan Shelley; Girard Luc; Sato Mitsuo; Kim Young; Pollack Jon; Peyton Michael; Zou Ying; Kurie Jonathan M; Dimaio J Michael; Milchgrub Sara; Smith Alice L; Souza Rhonda F; Gilbey Laura; Zhang Xi; Gandia Kenia; Vaughan Melville B; Wright Woodring E; Gazdar Adi F; Shay Jerry W; Minna John D
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins.
Cancer research 2004;64(24):9027-34.
2004: Lam Stephen; leRiche Jean C; McWilliams Annette; Macaulay Calum; Dyachkova Yulia; Szabo Eva; Mayo John; Schellenberg Robert; Coldman Andy; Hawk Ernest; Gazdar Adi
A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(19):6502-11.
2004: Gazdar Adi F; Shigematsu Hisayuki; Herz Joachim; Minna John D
Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?
Trends in molecular medicine 2004;10(10):481-6.
2004: Takahashi Takao; Shivapurkar Narayan; Riquelme Erick; Shigematsu Hisayuki; Reddy Jyotsna; Suzuki Makoto; Miyajima Kuniharu; Zhou Xian; Bekele B Nebiyou; Gazdar Adi F; Wistuba Ignacio I
Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 1):6126-33.
2004: Wistuba Ignacio I; Gazdar Adi F
Gallbladder cancer: lessons from a rare tumour.
Nature reviews. Cancer 2004;4(9):695-706.
2004: Bailey-Wilson J E; Amos C I; Pinney S M; Petersen G M; de Andrade M; Wiest J S; Fain P; Schwartz A G; You M; Franklin W; Klein C; Gazdar A; Rothschild H; Mandal D; Coons T; Slusser J; Lee J; Gaba C; Kupert E; Perez A; Zhou X; Zeng D; Liu Q; Zhang Q; Seminara D; Minna J; Anderson M W
A major lung cancer susceptibility locus maps to chromosome 6q23-25.
American journal of human genetics 2004;75(3):460-74.
2004: Toyooka S; Suzuki M; Maruyama R; Toyooka K O; Tsukuda K; Fukuyama Y; Iizasa T; Aoe M; Date H; Fujisawa T; Shimizu N; Gazdar A F
The relationship between aberrant methylation and survival in non-small-cell lung cancers.
British journal of cancer 2004;91(4):771-4.
2004: Sunaga Noriaki; Miyajima Kuniharu; Suzuki Makoto; Sato Mitsuo; White Michael A; Ramirez Ruben D; Shay Jerry W; Gazdar Adi F; Minna John D
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer.
Cancer research 2004;64(12):4277-85.
2004: Minna John D; Gazdar Adi F; Sprang Stephen R; Herz Joachim
Cancer. A bull's eye for targeted lung cancer therapy.
Science (New York, N.Y.) 2004;304(5676):1458-61.
2004: Shivapurkar Narayan; Takahashi Takao; Reddy Jyotsna; Zheng Yingye; Stastny Victor; Collins Robert; Toyooka Shinichi; Suzuki Makato; Parikh Gunjan; Asplund Sheryl; Kroft Steven H; Timmons Charles; McKenna Robert W; Feng Ziding; Gazdar Adi F
Presence of simian virus 40 DNA sequences in human lymphoid and hematopoietic malignancies and their relationship to aberrant promoter methylation of multiple genes.
Cancer research 2004;64(11):3757-60.
2004: Toyooka Shinichi; Suzuki Makoto; Tsuda Toshihide; Toyooka Kiyomi O; Maruyama Riichiroh; Tsukuda Kazunori; Fukuyama Yasuro; Iizasa Toshihiko; Fujisawa Takehiko; Shimizu Nobuyoshi; Minna John D; Gazdar Adi F
Dose effect of smoking on aberrant methylation in non-small cell lung cancers.
International journal of cancer. Journal international du cancer 2004;110(3):462-4.
2004: Gazdar Adi F; Miyajima Kuniharu; Reddy Jyotsna; Sathyanarayana Ubaradka G; Shigematsu Hisayuki; Suzuki Makoto; Takahashi Takao; Shivapurkar Narayan
Molecular targets for cancer therapy and prevention.
Chest 2004;125(5 Suppl):97S-101S.
2004: Takahashi Takao; Shivapurkar Narayan; Reddy Jyotsna; Shigematsu Hisayuki; Miyajima Kuniharu; Suzuki Makoto; Toyooka Shinichi; Zöchbauer-Müller Sabine; Drach Johannes; Parikh Gunjan; Zheng Yingye; Feng Ziding; Kroft Steven H; Timmons Charles; McKenna Robert W; Gazdar Adi F
DNA methylation profiles of lymphoid and hematopoietic malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):2928-35.
2004: Suzuki Makoto; Sunaga Noriaki; Shames David S; Toyooka Shinichi; Gazdar Adi F; Minna John D
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
Cancer research 2004;64(9):3137-43.
2004: Shivapurkar Narayan; Toyooka Shinichi; Toyooka Kiyomi O; Reddy Jyotsna; Miyajima Kuniharu; Suzuki Makoto; Shigematsu Hisayuki; Takahashi Takao; Parikh Gunjan; Pass Harvey I; Chaudhary Preet M; Gazdar Adi F
Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.
International journal of cancer. Journal international du cancer 2004;109(5):786-92.
2004: Maruyama Riichiroh; Sugio Kenji; Yoshino Ichiro; Maehara Yoshihiko; Gazdar Adi F
Hypermethylation of FHIT as a prognostic marker in nonsmall cell lung carcinoma.
Cancer 2004;100(7):1472-7.
2004: Samuels Yardena; Wang Zhenghe; Bardelli Alberto; Silliman Natalie; Ptak Janine; Szabo Steve; Yan Hai; Gazdar Adi; Powell Steven M; Riggins Gregory J; Willson James K V; Markowitz Sanford; Kinzler Kenneth W; Vogelstein Bert; Velculescu Victor E
High frequency of mutations of the PIK3CA gene in human cancers.
Science (New York, N.Y.) 2004;304(5670):554.
2004: Dote Hideaki; Toyooka Shinichi; Tsukuda Kazunori; Yano Masaaki; Ouchida Mamoru; Doihara Hiroyoshi; Suzuki Makoto; Chen Hong; Hsieh Jer-Tsong; Gazdar Adi F; Shimizu Nobuyoshi
Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):2082-9.
2004: Sathyanarayana Ubaradka G; Maruyama Riichiroh; Padar Asha; Suzuki Makoto; Bondaruk Jolanta; Sagalowsky Arthur; Minna John D; Frenkel Eugene P; Grossman H Barton; Czerniak Bogdan; Gazdar Adi F
Molecular detection of noninvasive and invasive bladder tumor tissues and exfoliated cells by aberrant promoter methylation of laminin-5 encoding genes.
Cancer research 2004;64(4):1425-30.
2003: Sathyanarayana Ubaradka G; Padar Asha; Suzuki Makoto; Maruyama Riichiroh; Shigematsu Hisayuki; Hsieh Jer-Tsong; Frenkel Eugene P; Gazdar Adi F
Aberrant promoter methylation of laminin-5-encoding genes in prostate cancers and its relationship to clinicopathological features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6395-400.
2003: Sathyanarayana Ubaradka G; Padar Asha; Huang Chun Xian; Suzuki Makoto; Shigematsu Hisayuki; Bekele B Nebiyou; Gazdar Adi F
Aberrant promoter methylation and silencing of laminin-5-encoding genes in breast carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6389-94.
2003: Lam Stephen; Xu Xiaochun; Parker-Klein Helga; Le Riche Jean C; Macaulay Calum; Guillaud Martial; Coldman Andy; Gazdar Adi; Lotan Reuben
Surrogate end-point biomarker analysis in a retinol chemoprevention trial in current and former smokers with bronchial dysplasia.
International journal of oncology 2003;23(6):1607-13.
2003: Gazdar Adi F; Carbone Michele
Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40.
Clinical lung cancer 2003;5(3):177-81.
2003: Suzuki Makoto; Toyooka Shinichi; Miyajima Kuniharu; Iizasa Toshihiko; Fujisawa Takehiko; Bekele Nebiyou B; Gazdar Adi F
Alterations in the mitochondrial displacement loop in lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5636-41.
2003: Zöchbauer-Müller Sabine; Lam Stephen; Toyooka Shinichi; Virmani Arvind K; Toyooka Kiyomi O; Seidl Sonja; Minna John D; Gazdar Adi F
Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers.
International journal of cancer. Journal international du cancer 2003;107(4):612-6.
2003: Virmani Arvind; Rathi Asha; Heda Shashank; Sugio Kenji; Lewis Cheryl; Tonk Vijay; Takahashi Takashi; Roth Jack A; Minna John D; Euhus David M; Gazdar Adi F
Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers.
International journal of cancer. Journal international du cancer 2003;107(3):341-5.
2003: Padar Asha; Sathyanarayana Ubaradka G; Suzuki Makoto; Maruyama Riichiroh; Hsieh Jer-Tsong; Frenkel Eugene P; Minna John D; Gazdar Adi F
Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4730-4.
2003: Gazdar Adi F
Environmental tobacco smoke, carcinogenesis, and angiogenesis: a double whammy?
Cancer cell 2003;4(3):159-60.
2003: Rathi Asha; Virmani Arvind K; Harada Kenichi; Timmons Charles F; Miyajima Kuniharu; Hay Robert J; Mastrangelo Domenico; Maitra Anirban; Tomlinson Gail E; Gazdar Adi F
Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3674-8.
2003: Wistuba Ignacio I; Behrens Carmen; Albores-Saavedra Jorge; Delgado Ruby; Lopez Francisco; Gazdar Adi F
Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3615-9.
2003: Toyooka Shinichi; Toyooka Kiyomi O; Miyajima Kuniharu; Reddy Jyotsna L; Toyota Minoru; Sathyanarayana Ubradka G; Padar Asha; Tockman Melvyn S; Lam Stephen; Shivapurkar Narayan; Gazdar Adi F
Epigenetic down-regulation of death-associated protein kinase in lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):3034-41.
2003: Virmani Arvind; Rathi Asha; Sugio Kenji; Sathyanarayana Ubaradka G; Toyooka Shinichi; Kischel Frank C; Tonk Vijay; Padar Asha; Takahashi Takashi; Roth Jack A; Euhus David M; Minna John D; Gazdar Adi F
Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer.
International journal of cancer. Journal international du cancer 2003;106(2):198-204.
2003: Carbone Michele; Bocchetta Maurizio; Cristaudo Alfonso; Emri Salih; Gazdar Adi; Jasani Bharat; Lednicky John; Miele Lucio; Mutti Luciano; Pass Harvey I; Ramael Marc; Rizzo Paola; Testa Joseph R; Weggen Sascha; Yeung Anthony
SV40 and human brain tumors.
International journal of cancer. Journal international du cancer 2003;106(1):140-2; author reply 143-5.
2003: Sathyanarayana Ubaradka G; Toyooka Shinichi; Padar Asha; Takahashi Takashi; Brambilla Elizabeth; Minna John D; Gazdar Adi F
Epigenetic inactivation of laminin-5-encoding genes in lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2665-72.
2003: Shivapurkar Narayan; Reddy Jyotsna; Chaudhary Preet M; Gazdar Adi F
Apoptosis and lung cancer: a review.
Journal of cellular biochemistry 2003;88(5):885-98.
2003: Sakaguchi Masahiro; Virmani Arvind; Dudak Marla W; Peters George N; Leitch A Marilyn; Saboorian Hossein; Gazdar Adi F; Euhus David M
Clinical relevance of reverse transcriptase-polymerase chain reaction for the detection of axillary lymph node metastases in breast cancer.
Annals of surgical oncology 2003;10(2):117-25.
2003: Toyooka Shinichi; Tsuda Toshihide; Gazdar Adi F
The TP53 gene, tobacco exposure, and lung cancer.
Human mutation 2003;21(3):229-39.
2003: Corn Paul G; Summers Matthew K; Fogt Franz; Virmani Arvind K; Gazdar Adi F; Halazonetis Thanos D; El-Deiry Wafik S
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
Carcinogenesis 2003;24(1):47-51.
2003: Toyooka Shinichi; Maruyama Riichiroh; Toyooka Kiyomi O; McLerran Dale; Feng Ziding; Fukuyama Yasuro; Virmani Arvind K; Zochbauer-Muller Sabine; Tsukuda Kazunori; Sugio Kenji; Shimizu Nobuyoshi; Shimizu Kenji; Lee Huei; Chen Chih-Yi; Fong Kwun M; Gilcrease Michael; Roth Jack A; Minna John D; Gazdar Adi F
Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer.
International journal of cancer. Journal international du cancer 2003;103(2):153-60.
2003: Chen Hong; Toyooka Shinichi; Gazdar Adi F; Hsieh Jer-Tsong
Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines.
The Journal of biological chemistry 2003;278(5):3121-30.
2003: Lam Stephen; MacAulay Calum; LeRiche Jean C; Gazdar Adi F
Key issues in lung cancer chemoprevention trials of new agents.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;163():182-95; discussion 264-6.
2003: Virmani Arvind K; Gazdar Adi F
Tumor suppressor genes in lung cancer.
Methods in molecular biology (Clifton, N.J.) 2003;222():97-115.
2003: Wistuba Ignacio I; Gazdar Adi F
Characteristic genetic alterations in lung cancer.
Methods in molecular medicine 2003;74():3-28.
2002: Shivapurkar Narayan; Reddy Jyotsna; Matta Hittu; Sathyanarayana Ubaradka G; Huang C X; Toyooka Shinichi; Minna John D; Chaudhary Preet M; Gazdar Adi F
Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification.
Oncogene 2002;21(55):8510-4.
2002: Sato Fumiaki; Shibata David; Harpaz Noam; Xu Yan; Yin Jing; Mori Yuriko; Wang Suna; Olaru Andreea; Deacu Elena; Selaru Florin M; Kimos Martha C; Hytiroglou Prodromos; Young Joanne; Leggett Barbara; Gazdar Adi F; Toyooka Shinichi; Abraham John M; Meltzer Stephen J
Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma.
Cancer research 2002;62(23):6820-2.
2002: Gazdar Adi F; Butel Janet S; Carbone Michele
SV40 and human tumours: myth, association or causality?
Nature reviews. Cancer 2002;2(12):957-64.
2002: Matta Hittu; Eby Michael T; Gazdar Adi F; Chaudhary Preet M
Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis.
Cancer biology & therapy 2002;1(6):652-60.
2002: Rathi Asha; Virmani Arvind K; Schorge John O; Elias Keren J; Maruyama Riichiroh; Minna John D; Mok Samuel C; Girard Luc; Fishman David A; Gazdar Adi F
Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3324-31.
2002: Harada Kenichi; Toyooka Shinichi; Shivapurkar Narayan; Maitra Anirban; Reddy Jyotsna L; Matta Hittu; Miyajima Kuniharu; Timmons Charles F; Tomlinson Gail E; Mastrangelo Domenico; Hay Robert J; Chaudhary Preet M; Gazdar Adi F
Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines.
Cancer research 2002;62(20):5897-901.
2002: Wistuba Ignacio I; Mao Li; Gazdar Adi F
Smoking molecular damage in bronchial epithelium.
Oncogene 2002;21(48):7298-306.
2002: McWilliams Annette; MacAulay Calum; Gazdar Adi F; Lam Stephen
Innovative molecular and imaging approaches for the detection of lung cancer and its precursor lesions.
Oncogene 2002;21(45):6949-59.
2002: Wistuba I I; Maitra A; Carrasco R; Tang M; Troncoso P; Minna J D; Gazdar A F
High resolution chromosome 3p, 8p, 9q and 22q allelotyping analysis in the pathogenesis of gallbladder carcinoma.
British journal of cancer 2002;87(4):432-40.
2002: Toyooka Kiyomi O; Toyooka Shinichi; Maitra Anirban; Feng Qinghua; Kiviat Nancy C; Smith Alice; Minna John D; Ashfaq Raheela; Gazdar Adi F
Establishment and validation of real-time polymerase chain reaction method for CDH1 promoter methylation.
The American journal of pathology 2002;161(2):629-34.
2002: Suh Young-Ah; Lee Ho-Young; Virmani Arvind; Wong Jiemin; Mann Koren K; Miller Wilson H; Gazdar Adi; Kurie Jonathan M
Loss of retinoic acid receptor beta gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines.
Cancer research 2002;62(14):3945-9.
2002: Toyooka Shinichi; Fukuyama Yasuro; Wistuba Ignacio I; Tockman Melvyn S; Minna John D; Gazdar Adi F
Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2292-7.
2002: Lam Stephen; MacAulay Calum; Le Riche Jean C; Dyachkova Yulia; Coldman Andy; Guillaud Martial; Hawk Ernest; Christen Marie-Odile; Gazdar Adi F
A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia.
Journal of the National Cancer Institute 2002;94(13):1001-9.
2002: Harada Kenichi; Toyooka Shinichi; Maitra Anirban; Maruyama Riichiroh; Toyooka Kiyomi O; Timmons Charles F; Tomlinson Gail E; Mastrangelo Domenico; Hay Robert J; Minna John D; Gazdar Adi F
Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines.
Oncogene 2002;21(27):4345-9.
2002: Toyooka Shinichi; Carbone Michele; Toyooka Kiyomi O; Bocchetta Maurizio; Shivapurkar Narayan; Minna John D; Gazdar Adi F
Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells.
Oncogene 2002;21(27):4340-4.
2002: Toyooka Shinichi; Toyooka Kiyomi O; Harada Kenichi; Miyajima Kuniharu; Makarla Prakash; Sathyanarayana Ubaradka G; Yin Jing; Sato Fumiaki; Shivapurkar Narayan; Meltzer Stephen J; Gazdar Adi F
Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas.
Cancer research 2002;62(12):3382-6.
2002: Wistuba Ignacio I; Ashfaq Raheela; Maitra Anirban; Alvarez Hector; Riquelme Erick; Gazdar Adi F
Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma.
The American journal of pathology 2002;160(6):2073-9.
2002: Euhus David M; Cler Leslie; Shivapurkar Narayan; Milchgrub Sara; Peters George N; Leitch A Marilyn; Heda Shashank; Gazdar Adi F
Loss of heterozygosity in benign breast epithelium in relation to breast cancer risk.
Journal of the National Cancer Institute 2002;94(11):858-60.
2002: Minna John D; Fong Kwun; Zöchbauer-Müller Sabine; Gazdar Adi F
Molecular pathogenesis of lung cancer and potential translational applications.
Cancer journal (Sudbury, Mass.) 2002;8 Suppl 1():S41-6.
2002: Huang Jiaoti; Behrens Carmen; Wistuba Ignacio I; Gazdar Adi F; Jagirdar Jaishree
Clonality of combined tumors.
Archives of pathology & laboratory medicine 2002;126(4):437-41.
2002: Shivapurkar Narayan; Harada Kenichi; Reddy Jyotsna; Scheuermann Richard H; Xu Yin; McKenna Robert W; Milchgrub Sara; Kroft Steven H; Feng Ziding; Gazdar Adi F
Presence of simian virus 40 DNA sequences in human lymphomas.
Lancet 2002;359(9309):851-2.
2002: Virmani Arvind K; Tsou Jeffrey A; Siegmund Kimberly D; Shen Linda Y C; Long Tiffany I; Laird Peter W; Gazdar Adi F; Laird-Offringa Ite A
Hierarchical clustering of lung cancer cell lines using DNA methylation markers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(3):291-7.
2002: Minna John D; Roth Jack A; Gazdar Adi F
Focus on lung cancer.
Cancer cell 2002;1(1):49-52.
2002: Maitra Anirban; Gazdar Adi F; Moore Todd O; Moore Angela Yen
Loss of heterozygosity analysis of cutaneous melanoma and benign melanocytic nevi: laser capture microdissection demonstrates clonal genetic changes in acquired nevocellular nevi.
Human pathology 2002;33(2):191-7.
2002: Maruyama Riichiroh; Toyooka Shinichi; Toyooka Kiyomi O; Virmani Arvind K; Zöchbauer-Müller Sabine; Farinas Alfredo J; Minna John D; McConnell John; Frenkel Eugene P; Gazdar Adi F
Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):514-9.
2002: O'Shaughnessy Joyce A; Kelloff Gary J; Gordon Gary B; Dannenberg Andrew J; Hong Waun Ki; Fabian Carol J; Sigman Caroline C; Bertagnolli Monica M; Stratton Steven P; Lam Stephen; Nelson William G; Meyskens Frank L; Alberts David S; Follen Michele; Rustgi Anil K; Papadimitrakopoulou Vali; Scardino Peter T; Gazdar Adi F; Wattenberg Lee W; Sporn Michael B; Sakr Wael A; Lippman Scott M; Von Hoff Daniel D
Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):314-46.
2002: Shivapurkar Narayan; Toyooka Shinichi; Eby Michael T; Huang Chun Xian; Sathyanarayana Ubaradka G; Cunningham H Thomas; Reddy Jyotsna L; Brambilla Elizabeth; Takahashi Takashi; Minna John D; Chaudhary Preet M; Gazdar Adi F
Differential inactivation of caspase-8 in lung cancers.
Cancer biology & therapy 2002;1(1):65-9.
2002: Zöchbauer-Müller Sabine; Minna John D; Gazdar Adi F
Aberrant DNA methylation in lung cancer: biological and clinical implications.
The oncologist 2002;7(5):451-7.
2002: Zochbauer-Muller Sabine; Gazdar Adi F; Minna John D
Molecular pathogenesis of lung cancer.
Annual review of physiology 2002;64():681-708.
2001: Maruyama R; Toyooka S; Toyooka K O; Harada K; Virmani A K; Zöchbauer-Müller S; Farinas A J; Vakar-Lopez F; Minna J D; Sagalowsky A; Czerniak B; Gazdar A F
Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features.
Cancer research 2001;61(24):8659-63.
2001: Toyooka S; Toyooka K O; Maruyama R; Virmani A K; Girard L; Miyajima K; Harada K; Ariyoshi Y; Takahashi T; Sugio K; Brambilla E; Gilcrease M; Minna J D; Gazdar A F
DNA methylation profiles of lung tumors.
Molecular cancer therapeutics 2001;1(1):61-7.
2001: Miura N; Onuki N; Rathi A; Virmani A; Nakamoto S; Kishimoto Y; Murawaki Y; Kawasaki H; Hasegawa J; Oshimura M; Travis W D; Gazdar A F
hTR repressor-related gene on human chromosome 10p15.1.
British journal of cancer 2001;85(10):1510-4.
2001: Tomizawa Y; Sekido Y; Kondo M; Gao B; Yokota J; Roche J; Drabkin H; Lerman M I; Gazdar A F; Minna J D
Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13954-9.
2001: Xu X L; Wu L C; Du F; Davis A; Peyton M; Tomizawa Y; Maitra A; Tomlinson G; Gazdar A F; Weissman B E; Bowcock A M; Baer R; Minna J D
Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers.
Cancer research 2001;61(21):7943-9.
2001: Gazdar A F; Minna J D
Targeted therapies for killing tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10028-30.
2001: Toyooka S; Pass H I; Shivapurkar N; Fukuyama Y; Maruyama R; Toyooka K O; Gilcrease M; Farinas A; Minna J D; Gazdar A F
Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma.
Cancer research 2001;61(15):5727-30.
2001: Hoang M P; Maitra A; Gazdar A F; Albores-Saavedra J
Primary mammary small-cell carcinoma: a molecular analysis of 2 cases.
Human pathology 2001;32(7):753-7.
2001: Virmani A K; Rathi A; Sathyanarayana U G; Padar A; Huang C X; Cunnigham H T; Farinas A J; Milchgrub S; Euhus D M; Gilcrease M; Herman J; Minna J D; Gazdar A F
Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1998-2004.
2001: Maitra A; Wistuba I I; Washington C; Virmani A K; Ashfaq R; Milchgrub S; Gazdar A F; Minna J D
High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss.
The American journal of pathology 2001;159(1):119-30.
2001: Toyooka K O; Toyooka S; Virmani A K; Sathyanarayana U G; Euhus D M; Gilcrease M; Minna J D; Gazdar A F
Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas.
Cancer research 2001;61(11):4556-60.
2001: Burbee D G; Forgacs E; Zöchbauer-Müller S; Shivakumar L; Fong K; Gao B; Randle D; Kondo M; Virmani A; Bader S; Sekido Y; Latif F; Milchgrub S; Toyooka S; Gazdar A F; Lerman M I; Zabarovsky E; White M; Minna J D
Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.
Journal of the National Cancer Institute 2001;93(9):691-9.
2001: Zöchbauer-Müller S; Fong K M; Maitra A; Lam S; Geradts J; Ashfaq R; Virmani A K; Milchgrub S; Gazdar A F; Minna J D
5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.
Cancer research 2001;61(9):3581-5.
2001: Maitra A; Wistuba I I; Gazdar A F
Microdissection and the study of cancer pathways.
Current molecular medicine 2001;1(1):153-62.
2001: Virmani A K; Muller C; Rathi A; Zoechbauer-Mueller S; Mathis M; Gazdar A F
Aberrant methylation during cervical carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3):584-9.
2001: Forgacs E; Wren J D; Kamibayashi C; Kondo M; Xu X L; Markowitz S; Tomlinson G E; Muller C Y; Gazdar A F; Garner H R; Minna J D
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 2001;20(8):1005-9.
2001: Jasani B; Cristaudo A; Emri S A; Gazdar A F; Gibbs A; Krynska B; Miller C; Mutti L; Radu C; Tognon M; Procopio A
Association of SV40 with human tumours.
Seminars in cancer biology 2001;11(1):49-61.
2001: Maitra A; Rathi A; Gazdar A F; Sagalowsky A; Ashfaq R
Expression of the RNA component of human telemorase (hTR) in ThinPrep preparations from bladder washings.
Cancer 2001;93(1):73-9.
2001: Shivapurkar N; Maitra A; Milchgrub S; Gazdar A F
Deletions of chromosome 4 occur early during the pathogenesis of colorectal carcinoma.
Human pathology 2001;32(2):169-77.
2001: Zöchbauer-Müller S; Fong K M; Virmani A K; Geradts J; Gazdar A F; Minna J D
Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
Cancer research 2001;61(1):249-55.
2001: Maitra A; Gazdar A F
Tissue microdissection and processing.
Cancer treatment and research 2001;106():63-84.
2000: Zöchbauer-Müller S; Wistuba I I; Minna J D; Gazdar A F
Fragile histidine triad (FHIT) gene abnormalities in lung cancer.
Clinical lung cancer 2000;2(2):141-5.
2000: Behrens C; Travis L B; Wistuba I I; Davis S; Maitra A; Clarke E A; Lynch C F; Glimelius B; Wiklund T; Tarone R; Gazdar A F
Molecular changes in second primary lung and breast cancers after therapy for Hodgkin's disease.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(10):1027-35.
2000: Sherwood J B; Shivapurkar N; Lin W M; Ashfaq R; Miller D S; Gazdar A F; Muller C Y
Chromosome 4 deletions are frequent in invasive cervical cancer and differ between histologic variants.
Gynecologic oncology 2000;79(1):90-6.
2000: Girard L; Zöchbauer-Müller S; Virmani A K; Gazdar A F; Minna J D
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
Cancer research 2000;60(17):4894-906.
2000: Maitra A; Ramnani D M; Margraf L R; Gazdar A F
Synchronous wilms tumor and fibrolamellar hepatocellular carcinoma: report of a case.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2000;3(5):492-6.
2000: Virmani A K; Rathi A; Zöchbauer-Müller S; Sacchi N; Fukuyama Y; Bryant D; Maitra A; Heda S; Fong K M; Thunnissen F; Minna J D; Gazdar A F
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Journal of the National Cancer Institute 2000;92(16):1303-7.
2000: Wistuba I I; Tomlinson G E; Behrens C; Virmani A; Geradts J; Blum J L; Minna J D; Gazdar A F
Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome.
Genes, chromosomes & cancer 2000;28(4):359-69.
2000: Lin W M; Ashfaq R; Michalopulos E A; Maitra A; Gazdar A F; Muller C Y
Molecular Papanicolaou tests in the twenty-first century: molecular analyses with fluid-based Papanicolaou technology.
American journal of obstetrics and gynecology 2000;183(1):39-45.
2000: Wistuba I I; Berry J; Behrens C; Maitra A; Shivapurkar N; Milchgrub S; Mackay B; Minna J D; Gazdar A F
Molecular changes in the bronchial epithelium of patients with small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2604-10.
2000: Wistuba I I; Behrens C; Virmani A K; Mele G; Milchgrub S; Girard L; Fondon J W; Garner H R; McKay B; Latif F; Lerman M I; Lam S; Gazdar A F; Minna J D
High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.
Cancer research 2000;60(7):1949-60.
2000: Milchgrub S; Wistuba I I; Kim B K; Rutherford C; Urban J; Cruz P D; Gazdar A F
Molecular identification of metastatic cancer to the skin using laser capture microdissection: a case report.
Cancer 2000;88(4):749-54.
2000: Wistuba I I; Gazdar A F
Molecular pathology of lung cancer.
Verhandlungen der Deutschen Gesellschaft für Pathologie 2000;84():96-105.
1999: Maitra A; Tavassoli F A; Albores-Saavedra J; Behrens C; Wistuba I I; Bryant D; Weinberg A G; Rogers B B; Saboorian M H; Gazdar A F
Molecular abnormalities associated with secretory carcinomas of the breast.
Human pathology 1999;30(12):1435-40.
1999: Shivapurkar N; Wiethege T; Wistuba I I; Salomon E; Milchgrub S; Muller K M; Churg A; Pass H; Gazdar A F
Presence of simian virus 40 sequences in malignant mesotheliomas and mesothelial cell proliferations.
Journal of cellular biochemistry 1999;76(2):181-8.
1999: Euhus D M; Maitra A; Wistuba I I; Ashfaq R; Alberts A; Gibbons D; Gazdar A F
Use of archival fine-needle aspirates for the allelotyping of tumors.
Cancer 1999;87(6):372-9.
1999: Delgado R; Rathi A; Albores-Saavedra J; Gazdar A F
Expression of the RNA component of human telomerase in adult testicular germ cell neoplasia.
Cancer 1999;86(9):1802-11.
1999: Park I W; Wistuba I I; Maitra A; Milchgrub S; Virmani A K; Minna J D; Gazdar A F
Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer.
Journal of the National Cancer Institute 1999;91(21):1863-8.
1999: Wistuba I I; Syed S; Behrens C; Duong M; Milchgrub S; Muller C Y; Jagirdar J; Gazdar A F
Comparison of molecular changes in cervical intraepithelial neoplasia in HIV-positive and HIV-indeterminate subjects.
Gynecologic oncology 1999;74(3):519-26.
1999: Maitra A; Wistuba I I; Gibbons D; Gazdar A F; Albores-Saavedra J
Allelic losses at chromosome 3p are seen in human papilloma virus 16 associated transitional cell carcinoma of the cervix.
Gynecologic oncology 1999;74(3):361-8.
1999: Maitra A; Salahuddin S; Timmons C F; Gazdar A F
Allelotyping nephrogenic rests: putative precursor lesions of Wilms tumors.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 1999;2(5):488-9.
1999: Shivapurkar N; Sood S; Wistuba I I; Virmani A K; Maitra A; Milchgrub S; Minna J D; Gazdar A F
Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas.
Cancer research 1999;59(15):3576-80.
1999: Wistuba I I; Behrens C; Gazdar A F
Pathogenesis of non-AIDS-defining cancers: a review.
AIDS patient care and STDs 1999;13(7):415-26.
1999: Flowers L C; Wistuba I I; Scurry J; Muller C Y; Ashfaq R; Miller D S; Minna J D; Gazdar A F
Genetic changes during the multistage pathogenesis of human papillomavirus positive and negative vulvar carcinomas.
Journal of the Society for Gynecologic Investigation 1999;6(4):213-21.
1999: Ramnani D M; Wistuba I I; Behrens C; Gazdar A F; Sobin L H; Albores-Saavedra J
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
Cancer 1999;86(1):14-21.
1999: Wang S S; Virmani A; Gazdar A F; Minna J D; Evans G A
Refined mapping of two regions of loss of heterozygosity on chromosome band 11q23 in lung cancer.
Genes, chromosomes & cancer 1999;25(2):154-9.
1999: Wistuba I I; Bryant D; Behrens C; Milchgrub S; Virmani A K; Ashfaq R; Minna J D; Gazdar A F
Comparison of features of human lung cancer cell lines and their corresponding tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(5):991-1000.
1999: Euhus D M; Maitra A; Wistuba I I; Alberts A; Albores-Saavedra J; Gazdar A F
Loss of heterozygosity at 3p in benign lesions preceding invasive breast cancer.
The Journal of surgical research 1999;83(1):13-8.
1999: Lam S; leRiche J C; Zheng Y; Coldman A; MacAulay C; Hawk E; Kelloff G; Gazdar A F
Sex-related differences in bronchial epithelial changes associated with tobacco smoking.
Journal of the National Cancer Institute 1999;91(8):691-6.
1999: Wistuba I I; Behrens C; Virmani A K; Milchgrub S; Syed S; Lam S; Mackay B; Minna J D; Gazdar A F
Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer.
Cancer research 1999;59(8):1973-9.
1999: Wu W; Kemp B L; Proctor M L; Gazdar A F; Minna J D; Hong W K; Mao L
Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer.
Cancer research 1999;59(8):1846-51.
1999: Maitra A; Yashima K; Rathi A; Timmons C F; Rogers B B; Shay J W; Gazdar A F
The RNA component of telomerase as a marker of biologic potential and clinical outcome in childhood neuroblastic tumors.
Cancer 1999;85(3):741-9.
1999: Onuki N; Wistuba I I; Travis W D; Virmani A K; Yashima K; Brambilla E; Hasleton P; Gazdar A F
Genetic changes in the spectrum of neuroendocrine lung tumors.
Cancer 1999;85(3):600-7.
1999: Sakaguchi M; Virmani A K; Ashfaq R; Rogers T E; Rathi A; Liu Y; Kodagoda D; Cunningham H T; Gazdar A F
Development of a sensitive, specific reverse transcriptase polymerase chain reaction-based assay for epithelial tumour cells in effusions.
British journal of cancer 1999;79(3-4):416-22.
1999: Wistuba I I; Behrens C; Milchgrub S; Bryant D; Hung J; Minna J D; Gazdar A F
Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma.
Oncogene 1999;18(3):643-50.
1999: Wistuba I I; Miquel J F; Gazdar A F; Albores-Saavedra J
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Human pathology 1999;30(1):21-5.
1999: Shivapurkar N; Virmani A K; Wistuba I I; Milchgrub S; Mackay B; Minna J D; Gazdar A F
Deletions of chromosome 4 at multiple sites are frequent in malignant mesothelioma and small cell lung carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(1):17-23.
1999: Wistuba I I; Thomas B; Behrens C; Onuki N; Lindberg G; Albores-Saavedra J; Gazdar A F
Molecular abnormalities associated with endocrine tumors of the uterine cervix.
Gynecologic oncology 1999;72(1):3-9.
1999: Rushing E J; Colvin S M; Gazdar A; Miura N; White C L; Coimbra C; Burns D K
Prognostic value of proliferation index and expression of the RNA component of human telomerase (hTR) in papillary meningiomas.
Journal of neuro-oncology 1999;45(3):199-207.
1998: Wistuba I I; Behrens C; Milchgrub S; Syed S; Ahmadian M; Virmani A K; Kurvari V; Cunningham T H; Ashfaq R; Minna J D; Gazdar A F
Comparison of features of human breast cancer cell lines and their corresponding tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):2931-8.
1998: Gazdar A F; Kurvari V; Virmani A; Gollahon L; Sakaguchi M; Westerfield M; Kodagoda D; Stasny V; Cunningham H T; Wistuba I I; Tomlinson G; Tonk V; Ashfaq R; Leitch A M; Minna J D; Shay J W
Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer.
International journal of cancer. Journal international du cancer 1998;78(6):766-74.
1998: Wang S S; Esplin E D; Li J L; Huang L; Gazdar A; Minna J; Evans G A
Alterations of the PPP2R1B gene in human lung and colon cancer.
Science (New York, N.Y.) 1998;282(5387):284-7.
1998: Forgacs E; Biesterveld E J; Sekido Y; Fong K; Muneer S; Wistuba I I; Milchgrub S; Brezinschek R; Virmani A; Gazdar A F; Minna J D
Mutation analysis of the PTEN/MMAC1 gene in lung cancer.
Oncogene 1998;17(12):1557-65.
1998: Oh Y; Proctor M L; Fan Y H; Su L K; Hong W K; Fong K M; Sekido Y S; Gazdar A F; Minna J D; Mao L
TSG101 is not mutated in lung cancer but a shortened transcript is frequently expressed in small cell lung cancer.
Oncogene 1998;17(9):1141-8.
1998: Yashima K; Maitra A; Rogers B B; Timmons C F; Rathi A; Pinar H; Wright W E; Shay J W; Gazdar A F
Expression of the RNA component of telomerase during human development and differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(9):805-13.
1998: Tomlinson G E; Chen T T; Stastny V A; Virmani A K; Spillman M A; Tonk V; Blum J L; Schneider N R; Wistuba I I; Shay J W; Minna J D; Gazdar A F
Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.
Cancer research 1998;58(15):3237-42.
1998: Sekido Y; Ahmadian M; Wistuba I I; Latif F; Bader S; Wei M H; Duh F M; Gazdar A F; Lerman M I; Minna J D
Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene.
Oncogene 1998;16(24):3151-7.
1998: Virmani A K; Tonk V S; Gazdar A F
Comparison between fluorescence in situ hybridization and classical cytogenetics in human tumors.
Anticancer research 1998;18(3A):1351-6.
1998: Wistuba I I; Behrens C; Milchgrub S; Virmani A K; Jagirdar J; Thomas B; Ioachim H L; Litzky L A; Brambilla E M; Minna J D; Gazdar A F
Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects.
JAMA : the journal of the American Medical Association 1998;279(19):1554-9.
1998: Yashima K; Maitra A; Timmons C F; Rogers B B; Pinar H; Shay J W; Gazdar A F
Expression of the RNA component of telomerase in Wilms tumor and nephrogenic rest recapitulates renal embryogenesis.
Human pathology 1998;29(5):536-42.
1998: Yamamoto Y; Wistuba I I; Kishimoto Y; Virmani A K; Vuitch F; Albores-Saavedra J; Gazdar A F
DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining.
Pathology international 1998;48(4):273-80.
1998: Yamamoto Y; Kishimoto Y; Wistuba I I; Virmani A K; Vuitch F; Gazdar A F; Albores-Saavedra J
DNA analysis at p53 locus in carcinomas arising from pleomorphic adenomas of salivary glands: comparison of molecular study and p53 immunostaining.
Pathology international 1998;48(4):265-72.
1998: Virmani A K; Fong K M; Kodagoda D; McIntire D; Hung J; Tonk V; Minna J D; Gazdar A F
Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.
Genes, chromosomes & cancer 1998;21(4):308-19.
1998: Yashima K; Ashfaq R; Nowak J; Von Gruenigen V; Milchgrub S; Rathi A; Albores-Saavedra J; Shay J W; Gazdar A F
Telomerase activity and expression of its RNA component in cervical lesions.
Cancer 1998;82(7):1319-27.
1998: Muller C Y; O'Boyle J D; Fong K M; Wistuba I I; Biesterveld E; Ahmadian M; Miller D S; Gazdar A F; Minna J D
Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type.
Journal of the National Cancer Institute 1998;90(6):433-9.
1998: Lam S; Kennedy T; Unger M; Miller Y E; Gelmont D; Rusch V; Gipe B; Howard D; LeRiche J C; Coldman A; Gazdar A F
Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy.
Chest 1998;113(3):696-702.
1998: Yashima K; Milchgrub S; Gollahon L S; Maitra A; Saboorian M H; Shay J W; Gazdar A F
Telomerase enzyme activity and RNA expression during the multistage pathogenesis of breast carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):229-34.
1997: Yashima K; Vuitch F; Gazdar A F; Fahey T J
Telomerase activity in benign and malignant thyroid diseases.
Surgery 1997;122(6):1141-5; discussion 1145-6.
1997: Brown D F; Gazdar A F; White C L; Yashima K; Shay J W; Rushing E J
Human telomerase RNA expression and MIB-1 (Ki-67) proliferation index distinguish hemangioblastomas from metastatic renal cell carcinomas.
Journal of neuropathology and experimental neurology 1997;56(12):1349-55.
1997: Rushing E J; Yashima K; Brown D F; White C L; Shay J W; Risser R C; Gazdar A F
Expression of telomerase RNA component correlates with the MIB-1 proliferation index in ependymomas.
Journal of neuropathology and experimental neurology 1997;56(10):1142-6.
1997: Wistuba I I; Lam S; Behrens C; Virmani A K; Fong K M; LeRiche J; Samet J M; Srivastava S; Minna J D; Gazdar A F
Molecular damage in the bronchial epithelium of current and former smokers.
Journal of the National Cancer Institute 1997;89(18):1366-73.
1997: Ahmadian M; Wistuba I I; Fong K M; Behrens C; Kodagoda D R; Saboorian M H; Shay J; Tomlinson G E; Blum J; Minna J D; Gazdar A F
Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands.
Cancer research 1997;57(17):3664-8.
1997: Wistuba I I; Montellano F D; Milchgrub S; Virmani A K; Behrens C; Chen H; Ahmadian M; Nowak J A; Muller C; Minna J D; Gazdar A F
Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma.
Cancer research 1997;57(15):3154-8.
1997: Sugio K; Molberg K; Albores-Saavedra J; Virmani A K; Kishimoto Y; Gazdar A F
K-ras mutations and allelic loss at 5q and 18q in the development of human pancreatic cancers.
International journal of pancreatology : official journal of the International Association of Pancreatology 1997;21(3):205-17.
1997: Yashima K; Litzky L A; Kaiser L; Rogers T; Lam S; Wistuba I I; Milchgrub S; Srivastava S; Piatyszek M A; Shay J W; Gazdar A F
Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas.
Cancer research 1997;57(12):2373-7.
1997: Fong K M; Biesterveld E J; Virmani A; Wistuba I; Sekido Y; Bader S A; Ahmadian M; Ong S T; Rassool F V; Zimmerman P V; Giaccone G; Gazdar A F; Minna J D
FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.
Cancer research 1997;57(11):2256-67.
1997: Yashima K; Piatyszek M A; Saboorian H M; Virmani A K; Brown D; Shay J W; Gazdar A F
Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes.
Journal of clinical pathology 1997;50(2):110-7.
1997: Vuitch F; Sekido Y; Fong K; Mackay B; Minna J D; Gazdar A F
Neuroendocrine tumors of the lung. Pathology and molecular biology.
Chest surgery clinics of North America 1997;7(1):21-47.
1996: Yamamoto Y; Virmani A K; Wistuba I I; McIntire D; Vuitch F; Albores-Saavedra J; Gazdar A F
Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands.
Human pathology 1996;27(11):1204-10.
1996: Minna J D; Gazdar A F
Translational research comes of age.
Nature medicine 1996;2(9):974-5.
1996: Yamamoto Y; Kishimoto Y; Virmani A K; Smith A; Vuitch F; Albores-Saavedra J; Gazdar A F
Mutations associated with carcinomas arising from pleomorphic adenomas of the salivary glands.
Human pathology 1996;27(8):782-6.
1996: Johnson B E; Bridges J D; Sobczeck M; Gray J; Linnoila R I; Gazdar A F; Hankins L; Steinberg S M; Edison M; Frame J N; Pass H; Nesbitt J; Holden D; Mulshine J L; Glatstein E; Ihde D C
Patients with limited-stage small-cell lung cancer treated with concurrent twice-daily chest radiotherapy and etoposide/cisplatin followed by cyclophosphamide, doxorubicin, and vincristine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(3):806-13.
1996: Tsai C M; Perng R P; Chang K T; Venzon D; Gazdar A F
Evaluation of the relative cytotoxic effects of anticancer agents in serum-supplemented versus serum-free media using a tetrazolium colorimetric assay.
Japanese journal of cancer research : Gann 1996;87(1):91-7.
1996: Tsai C M; Chang K T; Wu L H; Chen J Y; Gazdar A F; Mitsudomi T; Chen M H; Perng R P
Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines.
Cancer research 1996;56(1):206-9.
1996: Hiyama E; Gollahon L; Kataoka T; Kuroi K; Yokoyama T; Gazdar A F; Hiyama K; Piatyszek M A; Shay J W
Telomerase activity in human breast tumors.
Journal of the National Cancer Institute 1996;88(2):116-22.
1996: Johnson B E; Russell E; Simmons A M; Phelps R; Steinberg S M; Ihde D C; Gazdar A F
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
Journal of cellular biochemistry. Supplement 1996;24():210-7.
1996: Shaw G L; Gazdar A F; Phelps R; Steinberg S M; Linnoila R I; Johnson B E; Oie H K; Russell E K; Ghosh B C; Pass H I; Minna J D; Mulshine J L; Ihde D C
Correlation of in vitro drug sensitivity testing results with response to chemotherapy and survival: comparison of non-small cell lung cancer and small cell lung cancer.
Journal of cellular biochemistry. Supplement 1996;24():173-85.
1996: Phelps R M; Johnson B E; Ihde D C; Gazdar A F; Carbone D P; McClintock P R; Linnoila R I; Matthews M J; Bunn P A; Carney D; Minna J D; Mulshine J L
NCI-Navy Medical Oncology Branch cell line data base.
Journal of cellular biochemistry. Supplement 1996;24():32-91.
1996: Oie H K; Russell E K; Carney D N; Gazdar A F
Cell culture methods for the establishment of the NCI series of lung cancer cell lines.
Journal of cellular biochemistry. Supplement 1996;24():24-31.
1995: Burrows F J; Derbyshire E J; Tazzari P L; Amlot P; Gazdar A F; King S W; Letarte M; Vitetta E S; Thorpe P E
Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(12):1623-34.
1995: Ciernik I F; Krayenbühl Ciernik B H; Cockerell C J; Minna J D; Gazdar A F; Carbone D P
Expression of transforming growth factor beta and transforming growth factor beta receptors on AIDS-associated Kaposi's sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(10):1119-24.
1995: Rosenthal D I; Close L G; Lucci J A; Schold S C; Truelson J; Fathallah-Skaykh H; Kamen B; Vuitch F M; Gazdar A F; Griener J
Phase I studies of continuous-infusion paclitaxel given with standard aggressive radiation therapy for locally advanced solid tumors.
Seminars in oncology 1995;22(4 Suppl 9):13-7.
1995: Kishimoto Y; Sugio K; Hung J Y; Virmani A K; McIntire D D; Minna J D; Gazdar A F
Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers.
Journal of the National Cancer Institute 1995;87(16):1224-9.
1995: Hung J; Kishimoto Y; Sugio K; Virmani A; McIntire D D; Minna J D; Gazdar A F
Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma.
JAMA : the journal of the American Medical Association 1995;273(24):1908.
1995: Wistuba I I; Sugio K; Hung J; Kishimoto Y; Virmani A K; Roa I; Albores-Saavedra J; Gazdar A F
Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile.
Cancer research 1995;55(12):2511-5.
1995: Hiyama K; Hiyama E; Ishioka S; Yamakido M; Inai K; Gazdar A F; Piatyszek M A; Shay J W
Telomerase activity in small-cell and non-small-cell lung cancers.
Journal of the National Cancer Institute 1995;87(12):895-902.
1995: Sekido Y; Pass H I; Bader S; Mew D J; Christman M F; Gazdar A F; Minna J D
Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer.
Cancer research 1995;55(6):1227-31.
1995: Hung J; Kishimoto Y; Sugio K; Virmani A; McIntire D D; Minna J D; Gazdar A F
Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma.
JAMA : the journal of the American Medical Association 1995;273(7):558-63.
1995: Kishimoto Y; Sugio K; Mitsudomi T; Oyama T; Virmani A K; McIntire D D; Gazdar A F
Frequent loss of the short arm of chromosome 9 in resected non-small-cell lung cancers from Japanese patients and its association with squamous cell carcinoma.
Journal of cancer research and clinical oncology 1995;121(5):291-6.
1994: Carbone D P; Mitsudomi T; Chiba I; Piantadosi S; Rusch V; Nowak J A; McIntire D; Slamon D; Gazdar A; Minna J
p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. A preliminary report of LCSG 871.
Chest 1994;106(6 Suppl):377S-381S.
1994: Sugio K; Kishimoto Y; Virmani A K; Hung J Y; Gazdar A F
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
Cancer research 1994;54(22):5811-5.
1994: Ihde D C; Mulshine J L; Kramer B S; Steinberg S M; Linnoila R I; Gazdar A F; Edison M; Phelps R M; Lesar M; Phares J C
Prospective randomized comparison of high-dose and standard-dose etoposide and cisplatin chemotherapy in patients with extensive-stage small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(10):2022-34.
1994: Sekido Y; Bader S; Latif F; Gnarra J R; Gazdar A F; Linehan W M; Zbar B; Lerman M I; Minna J D
Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.
Oncogene 1994;9(6):1599-604.
1994: Mulshine J L; Johnson B E; Gazdar A F; Shaw G L; Kramer B S; Mitsudomi T; Minna J D; Pass H; Phelps R; Ghosh B
Integrated clinical and basic studies related to circumventing non-small cell lung cancer drug resistance.
Lung cancer (Amsterdam, Netherlands) 1994;10 Suppl 1():S73-81.
1994: Gazdar A F
The molecular and cellular basis of human lung cancer.
Anticancer research 1994;14(1B):261-7.
1994: Gazdar A F; Bader S; Hung J; Kishimoto Y; Sekido Y; Sugio K; Virmani A; Fleming J; Carbone D P; Minna J D
Molecular genetic changes found in human lung cancer and its precursor lesions.
Cold Spring Harbor symposia on quantitative biology 1994;59():565-72.
1993: Winter S F; Sekido Y; Minna J D; McIntire D; Johnson B E; Gazdar A F; Carbone D P
Antibodies against autologous tumor cell proteins in patients with small-cell lung cancer: association with improved survival.
Journal of the National Cancer Institute 1993;85(24):2012-8.
1993: Shaw G L; Gazdar A F; Phelps R; Linnoila R I; Ihde D C; Johnson B E; Oie H K; Pass H I; Steinberg S M; Ghosh B C
Individualized chemotherapy for patients with non-small cell lung cancer determined by prospective identification of neuroendocrine markers and in vitro drug sensitivity testing.
Cancer research 1993;53(21):5181-7.
1993: Kern J A; Torney L; Weiner D; Gazdar A; Shepard H M; Fendly B
Inhibition of human lung cancer cell line growth by an anti-p185HER2 antibody.
American journal of respiratory cell and molecular biology 1993;9(4):448-54.
1993: Mitsudomi T; Lam S; Shirakusa T; Gazdar A F
Detection and sequencing of p53 gene mutations in bronchial biopsy samples in patients with lung cancer.
Chest 1993;104(2):362-5.
1993: Tsai C M; Chang K T; Perng R P; Mitsudomi T; Chen M H; Kadoyama C; Gazdar A F
Correlation of intrinsic chemoresistance of non-small-cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutations.
Journal of the National Cancer Institute 1993;85(11):897-901.
1993: Linnoila R I; Gazdar A F; Funa K; Becker K L
Long-term selective culture of hamster pulmonary endocrine cells.
The Anatomical record 1993;236(1):231-40.
1993: Olopade O I; Buchhagen D L; Malik K; Sherman J; Nobori T; Bader S; Nau M M; Gazdar A F; Minna J D; Diaz M O
Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.
Cancer research 1993;53(10 Suppl):2410-5.
1993: Tsai C M; Hsiao S H; Frey C M; Chang K T; Perng R P; Gazdar A F; Kramer B S
Combination cytotoxic effects of cis-diamminedichloroplatinum(II) and 5-fluorouracil with and without leucovorin against human non-small cell lung cancer cell lines.
Cancer research 1993;53(5):1079-84.
1992: Kim J; Kaye F J; Henslee J G; Shively J E; Park J G; Lai S L; Linnoila R I; Mulshine J L; Gazdar A F
Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers.
International journal of cancer. Journal international du cancer 1992;52(5):718-25.
1992: Gazdar A F
The molecular biology of lung cancer.
The Tohoku journal of experimental medicine 1992;168(2):239-45.
1992: Winter S F; Minna J D; Johnson B E; Takahashi T; Gazdar A F; Carbone D P
Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation.
Cancer research 1992;52(15):4168-74.
1992: Ohsaki Y; Gazdar A F; Chen H C; Johnson B E
Antitumor activity of magainin analogues against human lung cancer cell lines.
Cancer research 1992;52(13):3534-8.
1992: Kaur G; Viallet J; Laborda J; Blair O; Gazdar A F; Minna J D; Sausville E A
Growth inhibition by cholera toxin of human lung carcinoma cell lines: correlation with GM1 ganglioside expression.
Cancer research 1992;52(12):3340-6.
1992: Giaccone G; Battey J; Gazdar A F; Oie H; Draoui M; Moody T W
Neuromedin B is present in lung cancer cell lines.
Cancer research 1992;52(9 Suppl):2732s-2736s.
1992: Bodner S M; Minna J D; Jensen S M; D'Amico D; Carbone D; Mitsudomi T; Fedorko J; Buchhagen D L; Nau M M; Gazdar A F
Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.
Oncogene 1992;7(4):743-9.
1992: Giaccone G; Gazdar A F; Beck H; Zunino F; Capranico G
Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.
Cancer research 1992;52(7):1666-74.
1992: Kern J A; Robinson R A; Gazdar A; Torney L; Weiner D B
Mechanisms of p185HER2 expression in human non-small cell lung cancer cell lines.
American journal of respiratory cell and molecular biology 1992;6(4):359-63.
1992: Gazdar A F
Molecular markers for the diagnosis and prognosis of lung cancer.
Cancer 1992;69(6 Suppl):1592-9.
1992: Broers J L; Jensen S M; Travis W D; Pass H; Whitsett J A; Singh G; Katyal S L; Gazdar A F; Minna J D; Linnoila R I
Expression of surfactant associated protein-A and Clara cell 10 kilodalton mRNA in neoplastic and non-neoplastic human lung tissue as detected by in situ hybridization.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):337-46.
1992: Linnoila R I; Jensen S M; Steinberg S M; Mulshine J L; Eggleston J C; Gazdar A F
Peripheral airway cell marker expression in non-small cell lung carcinoma. Association with distinct clinicopathologic features.
American journal of clinical pathology 1992;97(2):233-43.
1992: Linnoila R I; Mulshine J L; Steinberg S M; Gazdar A F
Expression of surfactant-associated protein in non-small-cell lung cancer: a discriminant between biologic subsets.
Journal of the National Cancer Institute. Monographs 1992;(13):61-6.
1992: Johnson B E; Brennan J F; Ihde D C; Gazdar A F
myc family DNA amplification in tumors and tumor cell lines from patients with small-cell lung cancer.
Journal of the National Cancer Institute. Monographs 1992;(13):39-43.
1992: Gazdar A F; Kadoyama C; Venzon D; Park J G; Tsai C M; Linnoila R I; Mulshine J L; Ihde D C; Giaccone G
Association between histological type and neuroendocrine differentiation on drug sensitivity of lung cancer cell lines.
Journal of the National Cancer Institute. Monographs 1992;(13):191-6.
1992: Lee M; Draoui M; Zia F; Gazdar A; Oie H; Bepler G; Bellot F; Tarr C; Kris R; Moody T W
Epidermal growth factor receptor monoclonal antibodies inhibit the growth of lung cancer cell lines.
Journal of the National Cancer Institute. Monographs 1992;(13):117-23.
1991: Carbone D P; Koros A M; Linnoila R I; Jewett P; Gazdar A F
Neural cell adhesion molecule expression and messenger RNA splicing patterns in lung cancer cell lines are correlated with neuroendocrine phenotype and growth morphology.
Cancer research 1991;51(22):6142-9.
1991: Mitsudomi T; Steinberg S M; Oie H K; Mulshine J L; Phelps R; Viallet J; Pass H; Minna J D; Gazdar A F
ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent.
Cancer research 1991;51(18):4999-5002.
1991: Mitsudomi T; Viallet J; Mulshine J L; Linnoila R I; Minna J D; Gazdar A F
Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines.
Oncogene 1991;6(8):1353-62.
1991: Kim J H; Takahashi T; Chiba I; Park J G; Birrer M J; Roh J K; De Lee H; Kim J P; Minna J D; Gazdar A F
Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.
Journal of the National Cancer Institute 1991;83(13):938-43.
1991: Whang-Peng J; Knutsen T; Gazdar A; Steinberg S M; Oie H; Linnoila I; Mulshine J; Nau M; Minna J D
Nonrandom structural and numerical chromosome changes in non-small-cell lung cancer.
Genes, chromosomes & cancer 1991;3(3):168-88.
1991: Brennan J; O'Connor T; Makuch R W; Simmons A M; Russell E; Linnoila R I; Phelps R M; Gazdar A F; Ihde D C; Johnson B E
myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens.
Cancer research 1991;51(6):1708-12.
1991: Tsai C M; Gazdar A F; Perng R P; Kramer B S
Schedule-dependent in vitro combination effects of methotrexate and 5-fluorouracil in human tumor cell lines.
International journal of cancer. Journal international du cancer 1991;47(3):401-7.
1990: Stevenson H; Gazdar A F; Phelps R; Linnoila R I; Ihde D C; Ghosh B; Walsh T; Woods E L; Oie H; O'Connor T
Tumor cell lines established in vitro: an independent prognostic factor for survival in non-small-cell lung cancer.
Annals of internal medicine 1990;113(10):764-70.
1990: Gazdar A F; Oie H K; Shackleton C H; Chen T R; Triche T J; Myers C E; Chrousos G P; Brennan M F; Stein C A; La Rocca R V
Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.
Cancer research 1990;50(17):5488-96.
1990: Gazdar A F; Linnoila R I; Kurita Y; Oie H K; Mulshine J L; Clark J C; Whitsett J A
Peripheral airway cell differentiation in human lung cancer cell lines.
Cancer research 1990;50(17):5481-7.
1990: Fridman R; Giaccone G; Kanemoto T; Martin G R; Gazdar A F; Mulshine J L
Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6698-702.
1990: Jensen S M; Gazdar A F; Cuttitta F; Russell E K; Linnoila R I
A comparison of synaptophysin, chromogranin, and L-dopa decarboxylase as markers for neuroendocrine differentiation in lung cancer cell lines.
Cancer research 1990;50(18):6068-74.
1990: Giaccone G; Kadoyama C; Maneckjee R; Venzon D; Alexander R B; Gazdar A F
Effects of tumor necrosis factor, alone or in combination with topoisomerase-II-targeted drugs, on human lung cancer cell lines.
International journal of cancer. Journal international du cancer 1990;46(2):326-9.
1990: Dmitrovsky E; Seifter E J; Gazdar A F; Tsai C M; Edison M; Brantley P; Veach S R; Batist G; Ihde D C; Mulshine J L
A phase II trial of carboplatin (CBDCA) in small-cell and non-small-cell lung cancer with correlation to in vitro analysis of cytotoxicity.
American journal of clinical oncology 1990;13(4):285-9.
1990: Moody T W; Lee M; Kris R M; Bellot F; Bepler G; Oie H; Gazdar A F
Lung carcinoid cell lines have bombesin-like peptides and EGF receptors.
Journal of cellular biochemistry 1990;43(2):139-47.
1990: Gazdar A F
Cell biology and molecular biology of small cell and non-small cell lung cancer.
Current opinion in oncology 1990;2(2):321-7.
1990: Bliss D P; Battey J F; Linnoila R I; Birrer M J; Gazdar A F; Johnson B E
Expression of the atrial natriuretic factor gene in small cell lung cancer tumors and tumor cell lines.
Journal of the National Cancer Institute 1990;82(4):305-10.
1990: Park J G; Kramer B S; Lai S L; Goldstein L J; Gazdar A F
Chemosensitivity patterns and expression of human multidrug resistance-associated MDR1 gene by human gastric and colorectal carcinoma cell lines.
Journal of the National Cancer Institute 1990;82(3):193-8.
1990: Harbour J W; Lai S L; Gazdar A F; Minna J D; Kaye F J
Expression in lung cancer of a transcribed sequence at the DNF15S2 locus at chromosome 3P21.
Anticancer research 1990;10(1):23-7.
1990: Gazdar A F; Steinberg S M; Russell E K; Linnoila R I; Oie H K; Ghosh B C; Cotelingam J D; Johnson B E; Minna J D; Ihde D C
Correlation of in vitro drug-sensitivity testing results with response to chemotherapy and survival in extensive-stage small cell lung cancer: a prospective clinical trial.
Journal of the National Cancer Institute 1990;82(2):117-24.
1990: Weiner D B; Nordberg J; Robinson R; Nowell P C; Gazdar A; Greene M I; Williams W V; Cohen J A; Kern J A
Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung.
Cancer research 1990;50(2):421-5.
1990: Levitt M L; Gazdar A F; Oie H K; Schuller H; Thacher S M
Cross-linked envelope-related markers for squamous differentiation in human lung cancer cell lines.
Cancer research 1990;50(1):120-8.
1990: Gazdar A F; Mulshine J L; Kramer B S
Biological, molecular, and clinical markers for the diagnosis and typing of lung cancer.
Immunology series 1990;53():453-68.
1990: Tsai C M; Ihde D C; Kadoyama C; Venzon D; Gazdar A F
Correlation of in vitro drug sensitivity testing of long-term small cell lung cancer cell lines with response and survival.
European journal of cancer (Oxford, England : 1990) 1990;26(11-12):1148-52.
1989: Takahashi T; Nau M M; Chiba I; Birrer M J; Rosenberg R K; Vinocour M; Levitt M; Pass H; Gazdar A F; Minna J D
p53: a frequent target for genetic abnormalities in lung cancer.
Science (New York, N.Y.) 1989;246(4929):491-4.
1989: Lai S L; Goldstein L J; Gottesman M M; Pastan I; Tsai C M; Johnson B E; Mulshine J L; Ihde D C; Kayser K; Gazdar A F
MDR1 gene expression in lung cancer.
Journal of the National Cancer Institute 1989;81(15):1144-50.
1989: Johnson B E; Whang-Peng J; Naylor S L; Zbar B; Brauch H; Lee E; Simmons A; Russell E; Nam M H; Gazdar A F
Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies.
Journal of the National Cancer Institute 1989;81(16):1223-8.
1989: Stevenson H C; Gazdar A F; Linnoila R I; Russell E K; Oie H K; Steinberg S M; Ihde D C
Lack of relationship between in vitro tumor cell growth and prognosis in extensive-stage small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(7):923-31.
1989: Gazdar A F
Innovative chemotherapy. Xenografts and in vitro drug sensitivity testing.
Chest 1989;96(1 Suppl):56S-59S.
1989: Gazdar A F
Advances in the biology of lung cancer. Clinical significance of neuroendocrine differentiation.
Chest 1989;96(1 Suppl):39S-41S.
1989: Tsai C M; Gazdar A F; Venzon D J; Steinberg S M; Dedrick R L; Mulshine J L; Kramer B S
Lack of in vitro synergy between etoposide and cis-diamminedichloroplatinum(II).
Cancer research 1989;49(9):2390-7.
1989: Goldstein L J; Galski H; Fojo A; Willingham M; Lai S L; Gazdar A; Pirker R; Green A; Crist W; Brodeur G M
Expression of a multidrug resistance gene in human cancers.
Journal of the National Cancer Institute 1989;81(2):116-24.
1989: Minna J D; Schütte J; Viallet J; Thomas F; Kaye F J; Takahashi T; Nau M; Whang-Peng J; Birrer M; Gazdar A F
Transcription factors and recessive oncogenes in the pathogenesis of human lung cancer.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1989;4():32-4.
1988: Park J G; Collins J M; Gazdar A F; Allegra C J; Steinberg S M; Greene R F; Kramer B S
Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines.
Journal of the National Cancer Institute 1988;80(19):1560-4.
1988: Linnoila R I; Mulshine J L; Steinberg S M; Funa K; Matthews M J; Cotelingam J D; Gazdar A F
Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas.
American journal of clinical pathology 1988;90(6):641-52.
1988: Johnson B E; Makuch R W; Simmons A D; Gazdar A F; Burch D; Cashell A W
myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines.
Cancer research 1988;48(18):5163-6.
1988: Helman L J; Gazdar A F; Park J G; Cohen P S; Cotelingam J D; Israel M A
Chromogranin A expression in normal and malignant human tissues.
The Journal of clinical investigation 1988;82(2):686-90.
1988: Johnson B E; Sakaguchi A Y; Gazdar A F; Minna J D; Burch D; Marshall A; Naylor S L
Restriction fragment length polymorphism studies show consistent loss of chromosome 3p alleles in small cell lung cancer patients' tumors.
The Journal of clinical investigation 1988;82(2):502-7.
1988: Gazdar A F; Helman L J; Israel M A; Russell E K; Linnoila R I; Mulshine J L; Schuller H M; Park J G
Expression of neuroendocrine cell markers L-dopa decarboxylase, chromogranin A, and dense core granules in human tumors of endocrine and nonendocrine origin.
Cancer research 1988;48(14):4078-82.
1988: Nakanishi Y; Mulshine J L; Kasprzyk P G; Natale R B; Maneckjee R; Avis I; Treston A M; Gazdar A F; Minna J D; Cuttitta F
Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.
The Journal of clinical investigation 1988;82(1):354-9.
1988: Harbour J W; Lai S L; Whang-Peng J; Gazdar A F; Minna J D; Kaye F J
Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.
Science (New York, N.Y.) 1988;241(4863):353-7.
1988: Gu J; Linnoila R I; Seibel N L; Gazdar A F; Minna J D; Brooks B J; Hollis G F; Kirsch I R
A study of myc-related gene expression in small cell lung cancer by in situ hybridization.
The American journal of pathology 1988;132(1):13-7.
1988: Carmichael J; Mitchell J B; DeGraff W G; Gamson J; Gazdar A F; Johnson B E; Glatstein E; Minna J D
Chemosensitivity testing of human lung cancer cell lines using the MTT assay.
British journal of cancer 1988;57(6):540-7.
1988: Gazdar A F; Linnoila R I
The pathology of lung cancer--changing concepts and newer diagnostic techniques.
Seminars in oncology 1988;15(3):215-25.
1988: Nakanishi Y; Cuttitta F; Kasprzyk P G; Avis I; Steinberg S M; Gazdar A F; Mulshine J L
Growth factor effects on small cell lung cancer cells using a colorimetric assay: can a transferrin-like factor mediate autocrine growth?
Experimental cell biology 1988;56(1-2):74-85.
1987: Park J G; Oie H K; Sugarbaker P H; Henslee J G; Chen T R; Johnson B E; Gazdar A
Characteristics of cell lines established from human colorectal carcinoma.
Cancer research 1987;47(24 Pt 1):6710-8.
1987: Park J G; Kramer B S; Steinberg S M; Carmichael J; Collins J M; Minna J D; Gazdar A F
Chemosensitivity testing of human colorectal carcinoma cell lines using a tetrazolium-based colorimetric assay.
Cancer research 1987;47(22):5875-9.
1987: Whang-Peng J; Freter C E; Knutsen T; Nanfro J J; Gazdar A
Translocation t(11;22) in esthesioneuroblastoma.
Cancer genetics and cytogenetics 1987;29(1):155-7.
1987: Ruckdeschel J C; Carney D N; Oie H K; Russell E K; Gazdar A F
In vitro chemosensitivity of human lung cancer cell lines.
Cancer treatment reports 1987;71(7-8):697-704.
1986: Fargion S; Carney D; Mulshine J; Rosen S; Bunn P; Jewett P; Cuttitta F; Gazdar A; Minna J
Heterogeneity of cell surface antigen expression of human small cell lung cancer detected by monoclonal antibodies.
Cancer research 1986;46(5):2633-8.
1986: Nau M M; Brooks B J; Carney D N; Gazdar A F; Battey J F; Sausville E A; Minna J D
Human small-cell lung cancers show amplification and expression of the N-myc gene.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):1092-6.
1986: Minna J D; Battey J F; Brooks B J; Cuttitta F; Gazdar A F; Johnson B E; Ihde D C; Lebacq-Verheyden A M; Mulshine J; Nau M M
Molecular genetic analysis reveals chromosomal deletion, gene amplification, and autocrine growth factor production in the pathogenesis of human lung cancer.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():843-53.
1986: Minna J D; Battey J F; Birrer M; Brooks B J; Cuttitta F; DeGreve J; Gazdar A F; Johnson B E; Nau M M; Sausville E A
Chromosomal deletion, gene amplification, alternative processing, and autocrine growth factor production in the pathogenesis of human lung cancer.
Princess Takamatsu symposia 1986;17():109-22.
1985: Nau M M; Brooks B J; Battey J; Sausville E; Gazdar A F; Kirsch I R; McBride O W; Bertness V; Hollis G F; Minna J D
L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer.
Nature 1985;318(6041):69-73.
1985: Bunn P A; Linnoila I; Minna J D; Carney D; Gazdar A F
Small cell lung cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express the Leu-7 antigenic determinant present on natural killer cells.
Blood 1985;65(3):764-8.

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