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Shmuel Banai; Michael Chorny; S David Gertz; Ilia Fishbein; Jianchuan Gao; Louise Perez; Galila Lazarovichi; Aviv Gazit; Alexander Levitzki; Gershon Golomb
Locally delivered nanoencapsulated tyrphostin (AGL-2043) reduces neointima formation in balloon-injured rat carotid and stented porcine coronary arteries.
Galia Blum; Aviv Gazit; Alexander Levitzki
Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics.
Aviv Gazit; Kevin W H Yee; Andrea Uecker; Frank-D Böhmer; Tobias Sjöblom; Arne Ostman; Johannes Waltenberger; Gershon Golomb; Shmuel Banai; Michael C Heinrich; Alexander Levitzki
Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit.

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All Publications

2005: Shmuel Banai; Michael Chorny; S David Gertz; Ilia Fishbein; Jianchuan Gao; Louise Perez; Galila Lazarovichi; Aviv Gazit; Alexander Levitzki; Gershon Golomb
Locally delivered nanoencapsulated tyrphostin (AGL-2043) reduces neointima formation in balloon-injured rat carotid and stented porcine coronary arteries.
Biomaterials 2005;26(4):451-61.
2003: Galia Blum; Aviv Gazit; Alexander Levitzki
Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics.
The Journal of biological chemistry 2003;278(42):40442-54.
2003: Aviv Gazit; Kevin W H Yee; Andrea Uecker; Frank-D Böhmer; Tobias Sjöblom; Arne Ostman; Johannes Waltenberger; Gershon Golomb; Shmuel Banai; Michael C Heinrich; Alexander Levitzki
Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit.
Bioorganic & medicinal chemistry 2003;11(9):2007-18.
2003: Rotem Karni; Sarit Mizrachi; Ella Reiss-Sklan; Aviv Gazit; Oded Livnah; Alexander Levitzki
The pp60c-Src inhibitor PP1 is non-competitive against ATP.
FEBS letters 2003;537(1-3):47-52.
2002: Hannah Ben-Bassat; Zipora Hartzstark; Rubina Levitzki; Benjamin Y Klein; Zipora Shlomai; Aviv Gazit; Alexander Levitzki
Tyrosine kinase inhibitors suppress the growth of non-hodgkin B lymphomas.
The Journal of pharmacology and experimental therapeutics 2002;303(1):163-71.
2000: Galia Blum; Aviv Gazit; Alexander Levitzki
Substrate competitive inhibitors of IGF-1 receptor kinase.
Biochemistry 2000;39(51):15705-12.
2000: Ilia Fishbein; Johannes Waltenberger; Shmuel Banai; L Rabinovich; Michael Chorny; Alexander Levitzki; Aviv Gazit; R Huber; Ulrike Mayr; S David Gertz; Gershon Golomb
Local delivery of platelet-derived growth factor receptor-specific tyrphostin inhibits neointimal formation in rats.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(3):667-76.
1999: T J Powell; Hannah Ben-Bassat; Benjamin Y Klein; Hui Chen; N Shenoy; J McCollough; B Narog; Aviv Gazit; Z Harzstark; Malka Chaouat; Rubina Levitzki; Cho Tang; J McMahon; Laura K Shawver; Alexander Levitzki
Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors.
The British journal of dermatology 1999;141(5):802-10.
1999: Hannah Ben-Bassat; S Rosenbaum-Mitrani; Zipora Hartzstark; Rubina Levitzki; Malka Chaouat; Zipora Shlomai; Benjamin Y Klein; N Kleinberger-Doron; Aviv Gazit; R Tsvieli; Alexander Levitzki
Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1442-57.
1999: E Poradosu; Aviv Gazit; Hadas Reuveni; Alexander Levitzki
Alpha-cyanocinnamide derivatives: a new family of non-peptide, non-sulfhydryl inhibitors of Ras farnesylation.
Bioorganic & medicinal chemistry 1999;7(8):1727-36.
1999: Johannes Waltenberger; Andrea Uecker; Jens Kroll; H Frank; Ulrike Mayr; J D Bjorge; Donald J Fujita; Aviv Gazit; Vinzenz Hombach; Alexander Levitzki; Frank-D Böhmer
A dual inhibitor of platelet-derived growth factor beta-receptor and Src kinase activity potently interferes with motogenic and mitogenic responses to PDGF in vascular smooth muscle cells. A novel candidate for prevention of vascular remodeling.
Circulation research 1999;85(1):12-22.
1998: Talma Brenner; E Poradosu; D Soffer; Camille Sicsic; Aviv Gazit; Alexander Levitzki
Suppression of experimental autoimmune encephalomyelitis by tyrphostin AG-556.
Experimental neurology 1998;154(2):489-98.
1998: N Kleinberger-Doron; N Shelah; Ricardo Capone; Aviv Gazit; Alexander Levitzki
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase.
Experimental cell research 1998;241(2):340-51.
1998: Shmuel Banai; Y Wolf; Gershon Golomb; A Pearle; Johannes Waltenberger; Ilia Fishbein; A Schneider; Aviv Gazit; Louise Perez; R Huber; Galila Lazarovichi; L Rabinovich; Alexander Levitzki; S David Gertz
PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine.
Circulation 1998;97(19):1960-9.
1997: Hannah Ben-Bassat; S Rosenbaum-Mitrani; Zipora Hartzstark; Zipora Shlomai; N Kleinberger-Doron; Aviv Gazit; G Plowman; Rubina Levitzki; R Tsvieli; Alexander Levitzki
Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes.
Cancer research 1997;57(17):3741-50.
1997: Giuseppe A Palumbo; N Yarom; Aviv Gazit; ziv Sandalon; Michal Baniyash; N Kleinberger-Doron; Alexander Levitzki; Dina Ben-Yehuda
The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2.
Cancer research 1997;57(12):2434-9.
1996: Aviv Gazit; N Osherov; Chaim Gilon; Alexander Levitzki
Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro.
Journal of medicinal chemistry 1996;39(25):4905-11.
1996: Gershon Golomb; Ilia Fishbein; Shmuel Banai; D Mishaly; D Moscovitz; S David Gertz; Aviv Gazit; E Poradosu; Alexander Levitzki
Controlled delivery of a tyrphostin inhibits intimal hyperplasia in a rat carotid artery injury model.
Atherosclerosis 1996;125(2):171-82.
1996: Aviv Gazit; J Chen; H App; Gerald McMahon; P Hirth; I Chen; Alexander Levitzki
Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines.
Bioorganic & medicinal chemistry 1996;4(8):1203-7.
1996: L M Strawn; Gerald McMahon; H App; Randall E Schreck; W R Kuchler; M P Longhi; T H Hui; Cho Tang; Alexander Levitzki; Aviv Gazit; I Chen; G Keri; László Őrfi; Werner Risau; Ingo Flamme; A Ullrich; KP Hirth; Laura K Shawver
Flk-1 as a target for tumor growth inhibition.
Cancer research 1996;56(15):3540-5.
1996: Aviv Gazit; H App; Gerald McMahon; J Chen; Alexander Levitzki; F D Bohmer
Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins.
Journal of medicinal chemistry 1996;39(11):2170-7.
1995: Hannah Ben-Bassat; D V Vardi; Aviv Gazit; S N Klaus; Malka Chaouat; Zipora Hartzstark; Alexander Levitzki
Tyrphostins suppress the growth of psoriatic keratinocytes.
Experimental dermatology 1995;4(2):82-8.
1995: Alexander Levitzki; Aviv Gazit
Tyrosine kinase inhibition: an approach to drug development.
Science (New York, N.Y.) 1995;267(5205):1782-8.
1994: I Posner; M Engel; Aviv Gazit; Alexander Levitzki
Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program.
Molecular pharmacology 1994;45(4):673-83.
1993: M Anafi; Aviv Gazit; A Zehavi; Yinon Ben-Neriah; Alexander Levitzki
Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate.
Blood 1993;82(12):3524-9.
1993: Aviv Gazit; N Osherov; I Posner; A Bar-Sinai; Chaim Gilon; Alexander Levitzki
Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Journal of medicinal chemistry 1993;36(23):3556-64.
1993: M Anafi; Aviv Gazit; Chaim Gilon; Y B Neriah; Alexander Levitzki
Tyrphostin-induced differentiation of mouse erythroleukemia cells.
FEBS letters 1993;330(3):260-4.
1993: N Osherov; Aviv Gazit; Chaim Gilon; Alexander Levitzki
Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins.
The Journal of biological chemistry 1993;268(15):11134-42.
1992: M C Bryckaert; A Eldor; M Fontenay; Aviv Gazit; N Osherov; C Gilon; Alexander Levitzki; Gérard Tobelem
Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins.
Experimental cell research 1992;199(2):255-61.
1992: M Anafi; Aviv Gazit; Chaim Gilon; Yinon Ben-Neriah; Alexander Levitzki
Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins.
The Journal of biological chemistry 1992;267(7):4518-23.
1991: Aviv Gazit; N Osherov; I Posner; P Yaish; E Poradosu; Chaim Gilon; Alexander Levitzki
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Journal of medicinal chemistry 1991;34(6):1896-907.
1991: A Dvir; Yoram Milner; O Chomsky; Chaim Gilon; Aviv Gazit; Alexander Levitzki
The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers.
The Journal of cell biology 1991;113(4):857-65.
1991: Alexander Levitzki; Aviv Gazit; N Osherov; I Posner; Chaim Gilon
Inhibition of protein-tyrosine kinases by tyrphostins.
Methods in enzymology 1991;201():347-61.
1989: I Posner; Aviv Gazit; Chaim Gilon; Alexander Levitzki
Tyrphostins inhibit the epidermal growth factor receptor-mediated breakdown of phosphoinositides.
FEBS letters 1989;257(2):287-91.
1989: Aviv Gazit; P Yaish; Chaim Gilon; Alexander Levitzki
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
Journal of medicinal chemistry 1989;32(10):2344-52.
1988: P Yaish; Aviv Gazit; Chaim Gilon; Alexander Levitzki
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.
Science (New York, N.Y.) 1988;242(4880):933-5.