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Gian Gazzola

Research Profile

Physiology

Biological Transport

Anatomy

Chemicals & Drugs

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TOP 3
Amelia Barilli; Ovidio Bussolati; Carlo Dionisi Vici; Mariona Font-Llitjós; Rita Gatti; Gian C Gazzola; Bianca M Goffredo; Maurizio Luisetti; Francesca Mariani; Diego Martinelli; Bianca Maria Rotoli; Rossana Visigalli; Valeria Dall'Asta
Impaired phagocytosis in macrophages from patients affected by lysinuric protein intolerance.
Massimiliano G Bianchi; Rita Gatti; L Torielli; G Padoani; Gian C Gazzola; Ovidio Bussolati
The glutamate transporter excitatory amino acid carrier 1 associates with the actin-binding protein alpha-adducin.
Rossana Visigalli; Amelia Barilli; Alessandro Parolari; Roberto Sala; Bianca Maria Rotoli; Ovidio Bussolati; Gian C Gazzola; Valeria Dall'Asta
Regulation of arginine transport and metabolism by protein kinase Calpha in endothelial cells: stimulation of CAT2 transporters and arginase activity.

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All Publications

2012: Amelia Barilli; Ovidio Bussolati; Carlo Dionisi Vici; Mariona Font-Llitjós; Rita Gatti; Gian C Gazzola; Bianca M Goffredo; Maurizio Luisetti; Francesca Mariani; Diego Martinelli; Bianca Maria Rotoli; Rossana Visigalli; Valeria Dall'Asta
Impaired phagocytosis in macrophages from patients affected by lysinuric protein intolerance.
Molecular genetics and metabolism 2012;105(4):585-9.
2010: Massimiliano G Bianchi; Rita Gatti; L Torielli; G Padoani; Gian C Gazzola; Ovidio Bussolati
The glutamate transporter excitatory amino acid carrier 1 associates with the actin-binding protein alpha-adducin.
Neuroscience 2010;169(2):584-95.
2010: Rossana Visigalli; Amelia Barilli; Alessandro Parolari; Roberto Sala; Bianca Maria Rotoli; Ovidio Bussolati; Gian C Gazzola; Valeria Dall'Asta
Regulation of arginine transport and metabolism by protein kinase Calpha in endothelial cells: stimulation of CAT2 transporters and arginase activity.
Journal of molecular and cellular cardiology 2010;49(2):260-70.
2010: Amelia Barilli; Bianca Maria Rotoli; Rossana Visigalli; Ovidio Bussolati; Gian C Gazzola; Zamir Kadija; Giuseppe Rodi; Francesca Mariani; Maria Lorena Ruzza; Maurizio Luisetti; Valeria Dall'Asta
In Lysinuric Protein Intolerance system y+L activity is defective in monocytes and in GM-CSF-differentiated macrophages.
Orphanet journal of rare diseases 2010;5():32.
2009: Bianca Maria Rotoli; Ellen I Closs; Amelia Barilli; Rossana Visigalli; Alexandra Simon; Alice Habermeier; Nicoletta Bianchi; Roberto Gambari; Gian C Gazzola; Ovidio Bussolati; Valeria Dall'Asta
Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles.
Pflügers Archiv : European journal of physiology 2009;458(6):1163-73.
2009: Massimiliano G Bianchi; Gian C Gazzola; Silvia Cagnin; Hiroyuki Kagechika; Ovidio Bussolati
The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.
Biochimica et biophysica acta 2009;1788(9):1861-8.
2008: Amelia Barilli; Rossana Visigalli; Roberto Sala; Gian C Gazzola; Alessandro Parolari; Elena Tremoli; Sabrina Bonomini; Alexandra Simon; Ellen I Closs; Valeria Dall'Asta; Ovidio Bussolati
In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function.
Cardiovascular research 2008;78(3):563-71.
2008: Massimiliano G Bianchi; Gian C Gazzola; L Tognazzi; Ovidio Bussolati
C6 glioma cells differentiated by retinoic acid overexpress the glutamate transporter excitatory amino acid carrier 1 (EAAC1).
Neuroscience 2008;151(4):1042-52.
2007: Saverio Tardito; Jacopo Uggeri; C Bozzetti; Massimiliano G Bianchi; Bianca Maria Rotoli; Renata Franchi-Gazzola; Gian C Gazzola; Rita Gatti; Ovidio Bussolati
The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.
Cancer chemotherapy and pharmacology 2007;60(5):751-8.
2007: Bianca Maria Rotoli; Valeria Dall'Asta; Amelia Barilli; Raffaele D'Ippolito; Annalisa Tipa; Dario Olivieri; Gian C Gazzola; Ovidio Bussolati
Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport.
American journal of respiratory cell and molecular biology 2007;37(1):105-12.
2007: Rossana Visigalli; Amelia Barilli; Ovidio Bussolati; Roberto Sala; Gian C Gazzola; Alessandro Parolari; Elena Tremoli; Alexandra Simon; Ellen I Closs; Valeria Dall'Asta
Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells.
Biochimica et biophysica acta 2007;1768(6):1479-87.
2006: Carlo Marchesi; Valeria Dall'Asta; Bianca Maria Rotoli; Massimiliano G Bianchi; Carlo Maggini; Gian C Gazzola; Ovidio Bussolati
Chlorpromazine, clozapine and olanzapine inhibit anionic amino acid transport in cultured human fibroblasts.
Amino acids 2006;31(2):93-9.
2006: Francesca Gaccioli; Charlie C Huang; Chuanping Wang; Elena Bevilacqua; Renata Franchi-Gazzola; Gian C Gazzola; Ovidio Bussolati; Martin D Snider; Maria Hatzoglou
Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.
The Journal of biological chemistry 2006;281(26):17929-40.
2006: Renata Franchi-Gazzola; Valeria Dall'Asta; Roberto Sala; Rossana Visigalli; Elena Bevilacqua; Francesca Gaccioli; Gian C Gazzola; Ovidio Bussolati
The role of the neutral amino acid transporter SNAT2 in cell volume regulation.
Acta physiologica (Oxford, England) 2006;187(1-2):273-83.
2006: Massimiliano G Bianchi; Bianca Maria Rotoli; Valeria Dall'Asta; Gian C Gazzola; Rita Gatti; Ovidio Bussolati
PKC-dependent stimulation of EAAT3 glutamate transporter does not require the integrity of actin cytoskeleton.
Neurochemistry international 2006;48(5):341-9.
2005: Elena Bevilacqua; Ovidio Bussolati; Valeria Dall'Asta; Francesca Gaccioli; Roberto Sala; Gian C Gazzola; Renata Franchi-Gazzola
SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress.
FEBS letters 2005;579(16):3376-80.
2005: Bianca Maria Rotoli; Ovidio Bussolati; Roberto Sala; Gian C Gazzola; Valeria Dall'Asta
The transport of cationic amino acids in human airway cells: expression of system y+L activity and transepithelial delivery of NOS inhibitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):810-2.
2005: Bianca Maria Rotoli; Jacopo Uggeri; Valeria Dall'Asta; Rossana Visigalli; Amelia Barilli; Rita Gatti; Guido Orlandini; Gian C Gazzola; Ovidio Bussolati
Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2005;15(6):281-92.
2004: Renata Franchi-Gazzola; Francesca Gaccioli; Elena Bevilacqua; Rossana Visigalli; Valeria Dall'Asta; Roberto Sala; Hélène Varoqui; Jeffrey D Erickson; Gian C Gazzola; Ovidio Bussolati
The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity.
Biochimica et biophysica acta 2004;1667(2):157-66.
2004: Bianca Maria Rotoli; Ovidio Bussolati; Roberto Sala; Amelia Barilli; Enrica Talarico; Gian C Gazzola; Valeria Dall'Asta
INFgamma stimulates arginine transport through system y+L in human monocytes.
FEBS letters 2004;571(1-3):177-81.
2004: Rossana Visigalli; Ovidio Bussolati; Roberto Sala; Amelia Barilli; Bianca Maria Rotoli; Alessandro Parolari; Francesco Alamanni; Gian C Gazzola; Valeria Dall'Asta
The stimulation of arginine transport by TNFalpha in human endothelial cells depends on NF-kappaB activation.
Biochimica et biophysica acta 2004;1664(1):45-52.
2004: Bianca Maria Rotoli; Guido Orlandini; Stefano Guizzardi; Jacopo Uggeri; Valeria Dall'Asta; Gian C Gazzola; Ovidio Bussolati; Rita Gatti
Ethanol increases the paracellular permeability of monolayers of CAPAN-1 pancreatic duct cells.
Journal of molecular histology 2004;35(4):355-62.
2003: Nicola Giuliani; Simona Colla; Mirca Lazzaretti; Roberto Sala; Giovanni Roti; Cristina Mancini; Sabrina Bonomini; Paolo Lunghi; Magda Hojden; Giovenzio Genestreti; Mirija Svaldi; Paolo Coser; Patrizia Fattori; Gabriella Sammarelli; Gian C Gazzola; Régis Bataille; Camillo Almici; Cecilia Caramatti; Lina Mangoni; Vittorio Rizzoli
Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis.
Blood 2003;102(2):638-45.
2002: Francesco Alamanni; Alessandro Parolari; Rossana Visigalli; Ovidio Bussolati; Patrizia Rubini; Roberto Sala; Luigi Bonati; Gian C Gazzola; Paolo Biglioli; Valeria Dall'Asta
Endothelial cell injury induced by preservation solutions: a confocal microscopy study.
The Annals of thoracic surgery 2002;73(5):1606-14; discussion 1614-5.
2002: Bianca Maria Rotoli; Guido Orlandini; Rita Gatti; Valeria Dall'Asta; Gian C Gazzola; Ovidio Bussolati
Employment of confocal microscopy for the dynamic visualization of domes in intact epithelial cell cultures.
Cells, tissues, organs 2002;170(4):237-45.
2002: Roberto Sala; Bianca Maria Rotoli; Emanuela Colla; Rossana Visigalli; Alessandro Parolari; Ovidio Bussolati; Gian C Gazzola; Valeria Dall'Asta
Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+).
American journal of physiology. Cell physiology 2002;282(1):C134-43.
2001: Renata Franchi-Gazzola; Rossana Visigalli; Valeria Dall'Asta; Roberto Sala; Seung Kyoon Woo; H Moo Kwon; Gian C Gazzola; Ovidio Bussolati
Amino acid depletion activates TonEBP and sodium-coupled inositol transport.
American journal of physiology. Cell physiology 2001;280(6):C1465-74.
2001: R F Gazzola; Roberto Sala; Ovidio Bussolati; Rossana Visigalli; Valeria Dall'Asta; Vadivel Ganapathy; Gian C Gazzola
The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression.
FEBS letters 2001;490(1-2):11-4.
2001: Ovidio Bussolati; Valeria Dall'Asta; Renata Franchi-Gazzola; Roberto Sala; Bianca Maria Rotoli; Rossana Visigalli; J Casado; M Lopez-Fontanals; Marçal Pastor-Anglada; Gian C Gazzola
The role of system A for neutral amino acid transport in the regulation of cell volume.
Molecular membrane biology 2001;18(1):27-38.
2000: Valeria Dall'Asta; Ovidio Bussolati; Roberto Sala; Bianca Maria Rotoli; Gianfranco Sebastio; Maria Pia Sperandeo; Generoso Andria; Gian C Gazzola
Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects.
American journal of physiology. Cell physiology 2000;279(6):C1829-37.
2000: Bianca Maria Rotoli; Ovidio Bussolati; Valeria Dall'Asta; Guido Orlandini; Rita Gatti; Gian C Gazzola
Secretin increases the paracellular permeability of CAPAN-1 pancreatic duct cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2000;10(1-2):13-25.
1999: Renata Franchi-Gazzola; Rossana Visigalli; Ovidio Bussolati; Valeria Dall'Asta; Gian C Gazzola
Adaptive increase of amino acid transport system A requires ERK1/2 activation.
The Journal of biological chemistry 1999;274(41):28922-8.
1999: Valeria Dall'Asta; Ovidio Bussolati; Roberto Sala; Alessandro Parolari; Francesco Alamanni; P Biglioli; Gian C Gazzola
Amino acids are compatible osmolytes for volume recovery after hypertonic shrinkage in vascular endothelial cells.
The American journal of physiology 1999;276(4 Pt 1):C865-72.
1999: Guido Orlandini; Nicoletta Ronda; Rita Gatti; Gian C Gazzola; Angelo F Borghetti
Receptor-ligand internalization.
Methods in enzymology 1999;307():340-50.
1998: Rita Gatti; Silvana Belletti; Guido Orlandini; Ovidio Bussolati; Valeria Dall'Asta; Gian C Gazzola
Comparison of annexin V and calcein-AM as early vital markers of apoptosis in adherent cells by confocal laser microscopy.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(8):895-900.
1997: Alessandro Parolari; Roberto Sala; Carlo Antona; Ovidio Bussolati; Francesco Alamanni; P Mezzadri; Valeria Dall'Asta; Gian C Gazzola; Paolo Biglioli
Hypertonicity induces injury to cultured human endothelium: attenuation by glutamine.
The Annals of thoracic surgery 1997;64(6):1770-5.
1997: Valeria Dall'Asta; Rita Gatti; Guido Orlandini; P A Rossi; Bianca Maria Rotoli; Roberto Sala; Ovidio Bussolati; Gian C Gazzola
Membrane potential changes visualized in complete growth media through confocal laser scanning microscopy of bis-oxonol-loaded cells.
Experimental cell research 1997;231(2):260-8.
1996: B M Rotoli; Ovidio Bussolati; V Dall' Asta; Else Hoffmann; G Cabrini; Gian C Gazzola
CFTR expression in C127 cells is associated with enhanced cell shrinkage and ATP extrusion in Cl(-)-free medium.
Biochemical and biophysical research communications 1996;227(3):755-61.
1996: R Franchi-Gazzola; R Visigalli; Ovidio Bussolati; Gian C Gazzola
Involvement of protein kinase Cepsilon in the stimulation of anionic amino acid transport in cultured human fibroblasts.
The Journal of biological chemistry 1996;271(42):26124-30.
1996: Valeria Dall'Asta; R Franchi-Gazzola; Ovidio Bussolati; Roberto Sala; B M Rotoli; P A Rossi; J Uggeri; S Belletti; R Visigalli; Gian C Gazzola
Modulation of transport systems for neutral and anionic amino acids in mesenchymal cells.
Biochemical Society transactions 1996;24(3):864-9.
1996: Ovidio Bussolati; J Uggeri; S Belletti; Valeria Dall'Asta; Gian C Gazzola
The stimulation of Na,K,Cl cotransport and of system A for neutral amino acid transport is a mechanism for cell volume increase during the cell cycle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(8):920-6.
1995: Ovidio Bussolati; S Belletti; J Uggeri; Rita Gatti; Guido Orlandini; Valeria Dall'Asta; Gian C Gazzola
Characterization of apoptotic phenomena induced by treatment with L-asparaginase in NIH3T3 cells.
Experimental cell research 1995;220(2):283-91.
1995: J Uggeri; S Belletti; Ovidio Bussolati; Valeria Dall'Asta; Gian C Gazzola
Suppression of anionic amino acid transport impairs the maintenance of intracellular glutamate in Ha-ras-expressing cells.
Biochemical and biophysical research communications 1995;211(3):878-84.
1994: B M Rotoli; Ovidio Bussolati; M Sironi; G Cabrini; Gian C Gazzola
CFTR protein is involved in the efflux of neutral amino acids.
Biochemical and biophysical research communications 1994;204(2):653-8.
1994: R Franchi-Gazzola; R Visigalli; Ovidio Bussolati; Gian C Gazzola
The regulation of sodium-dependent transport of anionic amino acids in cultured human fibroblasts.
FEBS letters 1994;352(2):109-12.
1994: Valeria Dall'Asta; P A Rossi; Ovidio Bussolati; Gian C Gazzola
Response of human fibroblasts to hypertonic stress. Cell shrinkage is counteracted by an enhanced active transport of neutral amino acids.
The Journal of biological chemistry 1994;269(14):10485-91.
1994: Valeria Dall'Asta; P A Rossi; Ovidio Bussolati; Gian C Gazzola
Regulatory volume decrease of cultured human fibroblasts involves changes in intracellular amino-acid pool.
Biochimica et biophysica acta 1994;1220(2):139-45.
1993: Ovidio Bussolati; Roberto Sala; A Astorri; B M Rotoli; Valeria Dall'Asta; Gian C Gazzola
Characterization of amino acid transport in human endothelial cells.
The American journal of physiology 1993;265(4 Pt 1):C1006-14.
1993: Ovidio Bussolati; J Uggeri; B M Rotoli; R Franchi-Gazzola; Gian C Gazzola
The relationship between sodium-dependent transport of anionic amino acids and cell proliferation.
Biochimica et biophysica acta 1993;1151(2):153-60.
1992: Ovidio Bussolati; P C Laris; B M Rotoli; Valeria Dall'Asta; Gian C Gazzola
Transport system ASC for neutral amino acids. An electroneutral sodium/amino acid cotransport sensitive to the membrane potential.
The Journal of biological chemistry 1992;267(12):8330-5.
1991: Ovidio Bussolati; B M Rotoli; P C Laris; Valeria Dall'Asta; Gian C Gazzola
The preferential interaction of L-threonine with transport system ASC in cultured human fibroblasts.
Biochimica et biophysica acta 1991;1070(2):305-12.
1991: B M Rotoli; Ovidio Bussolati; Valeria Dall'Asta; Gian C Gazzola
Membrane potential and amino acid transport in a mutant Chinese hamster ovary cell line.
Journal of cellular physiology 1991;146(3):417-24.
1991: Valeria Dall'Asta; Ovidio Bussolati; G G Guidotti; Gian C Gazzola
Energization of amino acid uptake by system A in cultured human fibroblasts.
The Journal of biological chemistry 1991;266(3):1591-6.
1990: R Franchi-Gazzola; Ovidio Bussolati; R Visigalli; B M Rotoli; P A Rossi; G G Guidotti; Gian C Gazzola
Phorbol esters stimulate the transport of anionic amino acids in cultured human fibroblasts.
Biochemical and biophysical research communications 1990;173(3):1304-10.
1990: Valeria Dall'Asta; P A Rossi; Ovidio Bussolati; G G Guidotti; Gian C Gazzola
The transport of L-glutamine into cultured human fibroblasts.
Biochimica et biophysica acta 1990;1052(1):106-12.
1989: B M Rotoli; Ovidio Bussolati; Valeria Dall'Asta; Gian C Gazzola
The transport of L-arginine in Chinese hamster ovary cells.
Biochemical and biophysical research communications 1989;164(3):1093-8.
1989: Ovidio Bussolati; P C Laris; F A Nucci; Valeria Dall'Asta; R Franchi-Gazzola; G G Guidotti; Gian C Gazzola
Influx of L-arginine is an indicator of membrane potential in human fibroblasts.
The American journal of physiology 1989;256(4 Pt 1):C930-5.
1988: N Longo; R Franchi-Gazzola; Ovidio Bussolati; Valeria Dall'Asta; F A Nucci; A Spisni; Gian C Gazzola
Glycine transport by cultured human fibroblasts.
Biochemical and biophysical research communications 1988;152(2):617-22.
1988: N Longo; R Franchi-Gazzola; Ovidio Bussolati; Valeria Dall'Asta; F A Nucci; Gian C Gazzola
Amino acid and sugar transport in mouse 3T3 cells expressing activated ras and neu oncogenes.
Annals of the New York Academy of Sciences 1988;551():374-7.
1987: Ovidio Bussolati; P C Laris; F A Nucci; Valeria Dall'Asta; N Longo; G G Guidotti; Gian C Gazzola
Dependence of L-arginine accumulation on membrane potential in cultured human fibroblasts.
The American journal of physiology 1987;253(3 Pt 1):C391-7.
1986: Valeria Dall'Asta; Gian C Gazzola; N Longo; Ovidio Bussolati; R Franchi-Gazzola; G G Guidotti
Perturbation of Na+ and K+ gradients in human fibroblasts incubated in unsupplemented saline solutions.
Biochimica et biophysica acta 1986;860(1):1-8.
1986: Ovidio Bussolati; P C Laris; N Longo; Valeria Dall'Asta; R Franchi-Gazzola; G G Guidotti; Gian C Gazzola
Effect of extracellular potassium on amino acid transport and membrane potential in fetal human fibroblasts.
Biochimica et biophysica acta 1986;854(2):240-50.
1985: N Longo; R Franchi-Gazzola; Ovidio Bussolati; Valeria Dall'Asta; P P Foà; G G Guidotti; Gian C Gazzola
Effect of insulin on the activity of amino acid transport systems in cultured human fibroblasts.
Biochimica et biophysica acta 1985;844(2):216-23.
1984: Gian C Gazzola; Valeria Dall'Asta; R Franchi-Gazzola; Ovidio Bussolati; N Longo; G G Guidotti
Post-translational control by carrier availability of amino acid transport in fetal human fibroblasts.
Biochemical and biophysical research communications 1984;120(1):172-8.
1983: Valeria Dall'Asta; Gian C Gazzola; R Franchi-Gazzola; Ovidio Bussolati; N Longo; G G Guidotti
Pathways of L-glutamic acid transport in cultured human fibroblasts.
The Journal of biological chemistry 1983;258(10):6371-9.
1982: R Franchi-Gazzola; Gian C Gazzola; Valeria Dall'Asta; G G Guidotti
The transport of alanine, serine, and cysteine in cultured human fibroblasts.
The Journal of biological chemistry 1982;257(16):9582-7.
1982: M F White; Gian C Gazzola; H N Christensen
Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts.
The Journal of biological chemistry 1982;257(8):4443-9.
1981: Gian C Gazzola; Valeria Dall'Asta; R Franchi-Gazzola; M F White
The cluster-tray method for rapid measurement of solute fluxes in adherent cultured cells.
Analytical biochemistry 1981;115(2):368-74.
1981: Gian C Gazzola; Valeria Dall'Asta; Ovidio Bussolati; M Makowske; H N Christensen
A stereoselective anomaly in dicarboxylic amino acid transport.
The Journal of biological chemistry 1981;256(12):6054-9.
1981: Gian C Gazzola; Valeria Dall'Asta; G G Guidotti
Adaptive regulation of amino acid transport in cultured human fibroblasts. Sites and mechanism of action.
The Journal of biological chemistry 1981;256(7):3191-8.
1980: Gian C Gazzola; Valeria Dall'Asta; G G Guidotti
The transport of neutral amino acids in cultured human fibroblasts.
The Journal of biological chemistry 1980;255(3):929-36.