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Nicholas Geacintov

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Lior Izhar; Isadora S Cohen; Nicholas E Geacintov; Omer Ziv; Zvi Livneh
Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.
Irine Khutsishvili; Luis A Marky; Dinshaw J Patel; Conor Crean; Nicholas E Geacintov; Na Zhang; Vladimir Shafirovich
Thermodynamic profiles and nuclear magnetic resonance studies of oligonucleotide duplexes containing single diastereomeric spiroiminodihydantoin lesions.
Yijin Tang; Shantu Amin; Suse Broyde; Yuqin Cai; Shuang Ding; Donald M Jerina; Chin H Lin; Zhi Liu; Fabian A Rodriguez; Jane M Sayer; Nicholas E Geacintov
Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.

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2013: Lior Izhar; Isadora S Cohen; Nicholas E Geacintov; Omer Ziv; Zvi Livneh
Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):E1462-9.
2013: Irine Khutsishvili; Luis A Marky; Dinshaw J Patel; Conor Crean; Nicholas E Geacintov; Na Zhang; Vladimir Shafirovich
Thermodynamic profiles and nuclear magnetic resonance studies of oligonucleotide duplexes containing single diastereomeric spiroiminodihydantoin lesions.
Biochemistry 2013;52(8):1354-63.
2012: Yijin Tang; Shantu Amin; Suse Broyde; Yuqin Cai; Shuang Ding; Donald M Jerina; Chin H Lin; Zhi Liu; Fabian A Rodriguez; Jane M Sayer; Nicholas E Geacintov
Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.
Biochemistry 2012;51(48):9751-62.
2012: Antonio S Minero; Natalia A Cherepanova; Nicholas E Geacintov; Alexander Kolbanovskiy; Olga V Lukashevich; Elizaveta S Gromova
Probing murine methyltransfease Dnmt3a interactions with benzo[a]pyrene-modified DNA by fluorescence methods.
The FEBS journal 2012;279(20):3965-80.
2012: Lee Lior-Hoffmann; Lihua Wang; Shenglong Wang; Suse Broyde; Nicholas E Geacintov; Yingkai Zhang
Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion.
Nucleic acids research 2012;40(18):9193-205.
2012: Yang Liu; Zhi Liu; Nicholas E Geacintov; Vladimir Shafirovich
Proton-coupled hole hopping in nucleosomal and free DNA initiated by site-specific hole injection.
Physical chemistry chemical physics : PCCP 2012;14(20):7400-10.
2012: Lidia V Skosareva; Nicholas E Geacintov; Alexander Kolbanovskiy; Natalia A Lebedeva; Nadejda I Rechkunova; Olga I Lavrik
Human DNA polymerase λ catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair.
DNA repair 2012;11(4):367-73.
2012: Yekaterina Rokhlenko; Nicholas E Geacintov; Vladimir Shafirovich
Lifetimes and reaction pathways of guanine radical cations and neutral guanine radicals in an oligonucleotide in aqueous solutions.
Journal of the American Chemical Society 2012;134(10):4955-62.
2012: Shuang Ding; Svetlana A Durandina; Suse Broyde; Yuqin Cai; Marina Kolbanovskiy; Konstantin Kropachev; Zhi Liu; Vladimir Shafirovich; Nicholas E Geacintov
Structural, energetic and dynamic properties of guanine(C8)-thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair.
Nucleic acids research 2012;40(6):2506-17.
2012: Yuqin Cai; Nicholas E Geacintov; Suse Broyde
Nucleotide excision repair efficiencies of bulky carcinogen-DNA adducts are governed by a balance between stabilizing and destabilizing interactions.
Biochemistry 2012;51(7):1486-99.
2012: Kok Seong Lim; Vladimir Shafirovich; Koli Taghizadeh; John S Wishnok; I Ramesh Babu; Nicholas E Geacintov; Peter C Dedon
Sequence-dependent variation in the reactivity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine toward oxidation.
Chemical research in toxicology 2012;25(2):366-73.
2011: Dara A Reeves; Shantu Amin; Suse Broyde; Yuqin Cai; Ying Chen; Shuang Ding; Alexander Kolbanovskiy; Marina Kolbanovskiy; Konstantin Kropachev; Jacek Krzeminski; Hong Mu; Dinshaw J Patel; Nicholas E Geacintov
Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion-base stacking interactions.
Nucleic acids research 2011;39(20):8752-64.
2011: Ayal Hendel; Heinz Jacobs; Jungmin Kim; Peter H L Krijger; Petra Langerak; Kyoo-young Lee; Thomas Carell; Alan D'Andrea; Noam Diamant; Nicholas E Geacintov; Zohar Goren; Kyungjae Myung; Thomas Reissner; Satoshi Tateishi; Zvi Livneh
PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.
PLoS genetics 2011;7(9):e1002262.
2011: Young-Ae Lee; Zhi Liu; Peter C Dedon; Nicholas E Geacintov; Vladimir Shafirovich
Solvent exposure associated with single abasic sites alters the base sequence dependence of oxidation of guanine in DNA in GG sequence contexts.
Chembiochem : a European journal of chemical biology 2011;12(11):1731-9.
2011: Byeong Hwa Yun; Nicholas E Geacintov; Vladimir Shafirovich
Generation of guanine-thymidine cross-links in DNA by peroxynitrite/carbon dioxide.
Chemical research in toxicology 2011;24(7):1144-52.
2011: Yang Liu; Dara Reeves; Bennett Van Houten; Alexander Kolbanovskiy; Marina Kolbanovskiy; Konstantin Kropachev; Judy L Bolton; Suse Broyde; Yuqin Cai; Shuang Ding; Nicholas E Geacintov
Probing for DNA damage with β-hairpins: similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro.
DNA repair 2011;10(7):684-96.
2011: Yuqin Cai; Shuang Ding; Nicholas E Geacintov; Suse Broyde
Intercalative conformations of the 14R (+)- and 14S (-)-trans-anti-DB[a,l]P-N⁶-dA adducts: molecular modeling and MD simulations.
Chemical research in toxicology 2011;24(4):522-31.
2011: Jacek Krzeminski; Konstantin Kropachev; Marina Kolbanovskiy; Dara Reeves; Alexander Kolbanovskiy; Byeong Hwa Yun; Nicholas E Geacintov; Shantu Amin; Karam El-Bayoumy
Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene.
Chemical research in toxicology 2011;24(1):65-72.
2010: Yuqin Cai; Lihua Wang; Shuang Ding; Adam Schwaid; Nicholas E Geacintov; Suse Broyde
A bulky DNA lesion derived from a highly potent polycyclic aromatic tumorigen stabilizes nucleosome core particle structure.
Biochemistry 2010;49(46):9943-5.
2010: Yuqin Cai; Konstantin Kropachev; Rong Xu; Yijin Tang; Marina Kolbanovskii; Alexander Kolbanovskii; Shantu Amin; Dinshaw J Patel; Suse Broyde; Nicholas E Geacintov
Distant neighbor base sequence context effects in human nucleotide excision repair of a benzo[a]pyrene-derived DNA lesion.
Journal of molecular biology 2010;399(3):397-409.
2010: Kristian Dreij; Kahn Rhrissorrakrai; Kristin C Gunsalus; Nicholas E Geacintov; David A Scicchitano
Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway.
Carcinogenesis 2010;31(6):1149-57.
2010: Jie Shao; Nicholas E Geacintov; Vladimir Shafirovich
Oxidative modification of guanine bases initiated by oxyl radicals derived from photolysis of azo compounds.
The journal of physical chemistry. B 2010;114(19):6685-92.
2010: Jie Shao; Nicholas E Geacintov; Vladimir Shafirovich
Oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine by oxyl radicals produced by photolysis of azo compounds.
Chemical research in toxicology 2010;23(5):933-8.
2010: Byeong Hwa Yun; Peter C Dedon; Nicholas E Geacintov; Vladimir Shafirovich
One-electron oxidation of a pyrenyl photosensitizer covalently attached to DNA and competition between its further oxidation and DNA hole injection.
Photochemistry and photobiology 2010;86(3):563-70.
2010: Olga Rechkoblit; Alexander Kolbanovskiy; Lucy Malinina; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4.
Nature structural & molecular biology 2010;17(3):379-88.
2010: Yuqin Cai; Dinshaw J Patel; Suse Broyde; Nicholas E Geacintov
Base sequence context effects on nucleotide excision repair.
Journal of nucleic acids 2010;2010():.
2009: Conor Crean; Jie Shao; Byeong Hwa Yun; Nicholas E Geacintov; Vladimir Shafirovich
The role of one-electron reduction of lipid hydroperoxides in causing DNA damage.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(40):10634-40.
2009: Lei Jia; Konstantin Kropachev; Shuang Ding; Bennett Van Houten; Nicholas E Geacintov; Suse Broyde
Exploring damage recognition models in prokaryotic nucleotide excision repair with a benzo[a]pyrene-derived lesion in UvrB.
Biochemistry 2009;48(38):8948-57.
2009: Conor Crean; Nicholas E Geacintov; Vladimir Shafirovich
Methylation of 2'-deoxyguanosine by a free radical mechanism.
The journal of physical chemistry. B 2009;113(38):12773-81.
2009: Na Zhang; Shuang Ding; Alexander Kolbanovskiy; Anant Shastry; Vladimir A Kuzmin; Judy L Bolton; Dinshaw J Patel; Suse Broyde; Nicholas E Geacintov
NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms.
Biochemistry 2009;48(30):7098-109.
2009: Pingna Xu; Lida Oum; Yuan-Cho Lee; Nicholas E Geacintov; Suse Broyde
Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase.
Biochemistry 2009;48(22):4677-90.
2009: Shuang Ding; Lei Jia; Alexander Durandin; Conor Crean; Alexander Kolbanovskiy; Vladimir Shafirovich; Suse Broyde; Nicholas E Geacintov
Absolute configurations of spiroiminodihydantoin and allantoin stereoisomers: comparison of computed and measured electronic circular dichroism spectra.
Chemical research in toxicology 2009;22(6):1189-93.
2009: Zhican Wang; Praneeth D Edirisinghe; Johann Sohn; Zhihui Qin; Nicholas E Geacintov; Gregory R J Thatcher; Judy L Bolton
Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells.
Chemical research in toxicology 2009;22(6):1129-36.
2009: Olga Rechkoblit; Lucy Malinina; Yuan Cheng; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases.
Structure (London, England : 1993) 2009;17(5):725-36.
2009: Konstantin Kropachev; Marina Kolbanovskii; Yuqin Cai; Fabian Rodríguez; Alexander Kolbanovskii; Yang Liu; Lu Zhang; Shantu Amin; Dinshaw J Patel; Suse Broyde; Nicholas E Geacintov
The sequence dependence of human nucleotide excision repair efficiencies of benzo[a]pyrene-derived DNA lesions: insights into the structural factors that favor dual incisions.
Journal of molecular biology 2009;386(5):1193-203.
2009: Yuqin Cai; Dinshaw J Patel; Nicholas E Geacintov; Suse Broyde
Differential nucleotide excision repair susceptibility of bulky DNA adducts in different sequence contexts: hierarchies of recognition signals.
Journal of molecular biology 2009;385(1):30-44.
2009: Shuang Ding; Alexander Kolbanovskiy; Alexander Durandin; Conor Crean; Vladimir Shafirovich; Suse Broyde; Nicholas E Geacintov
Absolute configurations of DNA lesions determined by comparisons of experimental ECD and ORD spectra with DFT calculations.
Chirality 2009;21 Suppl 1():E231-41.
2008: Lei Jia; Nicholas E Geacintov; Suse Broyde
The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions.
Nucleic acids research 2008;36(20):6571-84.
2008: Conor Crean; Nicholas E Geacintov; Vladimir Shafirovich
Intrastrand G-U cross-links generated by the oxidation of guanine in 5'-d(GCU) and 5'-r(GCU).
Free radical biology & medicine 2008;45(8):1125-34.
2008: Shuang Ding; Yan Wang; Alexander Kolbanovskiy; Alexander Durandin; Judy L Bolton; Richard B Van Breemen; Suse Broyde; Nicholas E Geacintov
Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry.
Chemical research in toxicology 2008;21(9):1739-48.
2008: Conor Crean; Young-Ae Lee; Byeong Hwa Yun; Nicholas E Geacintov; Vladimir Shafirovich
Oxidation of guanine by carbonate radicals derived from photolysis of carbonatotetramminecobalt(III) complexes and the pH dependence of intrastrand DNA cross-links mediated by guanine radical reactions.
Chembiochem : a European journal of chemical biology 2008;9(12):1985-91.
2008: Alexandra Dimitri; Lei Jia; Vladimir Shafirovich; Nicholas E Geacintov; Suse Broyde; David A Scicchitano
Transcription of DNA containing the 5-guanidino-4-nitroimidazole lesion by human RNA polymerase II and bacteriophage T7 RNA polymerase.
DNA repair 2008;7(8):1276-88.
2008: Shuang Ding; Robert Shapiro; Yuqin Cai; Nicholas E Geacintov; Suse Broyde
Conformational properties of equilenin-DNA adducts: stereoisomer and base effects.
Chemical research in toxicology 2008;21(5):1064-73.
2008: Suse Broyde; Lihua Wang; Olga Rechkoblit; Nicholas E Geacintov; Dinshaw J Patel
Lesion processing: high-fidelity versus lesion-bypass DNA polymerases.
Trends in biochemical sciences 2008;33(5):209-19.
2008: Pingna Xu; Lida Oum; Nicholas E Geacintov; Suse Broyde
Nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in a Y-family DNA polymerase: a 5'-slippage mechanism.
Biochemistry 2008;47(9):2701-9.
2008: Young Ae Lee; Alexander Durandin; Peter C Dedon; Nicholas E Geacintov; Vladimir Shafirovich
Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: relationship between kinetics and distribution of alkali-labile lesions.
The journal of physical chemistry. B 2008;112(6):1834-44.
2008: Conor Crean; Nicholas E Geacintov; Vladimir Shafirovich
Pathways of arachidonic acid peroxyl radical reactions and product formation with guanine radicals.
Chemical research in toxicology 2008;21(2):358-73.
2008: Conor Crean; Yuriy Uvaydov; Nicholas E Geacintov; Vladimir Shafirovich
Oxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosines.
Nucleic acids research 2008;36(3):742-55.
2008: Suse Broyde; Lihua Wang; Ling Zhang; Olga Rechkoblit; Nicholas E Geacintov; Dinshaw J Patel
DNA adduct structure-function relationships: comparing solution with polymerase structures.
Chemical research in toxicology 2008;21(1):45-52.
2007: Yuqin Cai; Dinshaw J Patel; Nicholas E Geacintov; Suse Broyde
Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, flexible bending, and greater susceptibility to nucleotide excision repair.
Journal of molecular biology 2007;374(2):292-305.
2007: Byeong Hwa Yun; Young-Ae Lee; Seog K Kim; Vladimir Kuzmin; Alexander Kolbanovskiy; Peter C Dedon; Nicholas E Geacintov; Vladimir Shafirovich
Photosensitized oxidative DNA damage: from hole injection to chemical product formation and strand cleavage.
Journal of the American Chemical Society 2007;129(30):9321-32.
2007: VINCENT MOCQUET; Konstantin Kropachev; Marina Kolbanovskiy; Alexander Kolbanovskiy; Angels Tapias; Yuqin Cai; Suse Broyde; Nicholas E Geacintov; Jean-Marc Egly
The human DNA repair factor XPC-HR23B distinguishes stereoisomeric benzo[a]pyrenyl-DNA lesions.
The EMBO journal 2007;26(12):2923-32.
2007: Qian Ruan; Tongming Liu; Alexander Kolbanovskiy; Yang Liu; Jian Ren; Milan Skorvaga; Yue Zou; Joshua Lader; Brijesh Malkani; Shantu Amin; Bennett Van Houten; Nicholas E Geacintov
Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins.
Biochemistry 2007;46(23):7006-15.
2007: Lei Jia; Vladimir Shafirovich; Nicholas E Geacintov; Suse Broyde
Lesion specificity in the base excision repair enzyme hNeil1: modeling and dynamics studies.
Biochemistry 2007;46(18):5305-14.
2007: Oksana M Subach; Diana V Maltseva; Anant Shastry; Alexander Kolbanovskiy; Saulius Klimasauskas; Nicholas E Geacintov; Elizaveta S Gromova
The stereochemistry of benzo[a]pyrene-2'-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases.
The FEBS journal 2007;274(8):2121-34.
2007: Rebecca A Perlow-Poehnelt; Ilya Likhterov; Lihua Wang; David A Scicchitano; Nicholas E Geacintov; Suse Broyde
Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase.
The Journal of biological chemistry 2007;282(2):1397-408.
2007: Shuang Ding; Robert Shapiro; Nicholas E Geacintov; Suse Broyde
4-hydroxyequilenin-adenine lesions in DNA duplexes: stereochemistry, damage site, and structure.
Biochemistry 2007;46(1):182-91.
2007: Pingna Xu; Lida Oum; Lorena S Beese; Nicholas E Geacintov; Suse Broyde
Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.
Nucleic acids research 2007;35(13):4275-88.
2007: Young-Ae Lee; Byeong Hwa Yun; Seog K Kim; Yelena Margolin; Peter C Dedon; Nicholas E Geacintov; Vladimir Shafirovich
Mechanisms of oxidation of guanine in DNA by carbonate radical anion, a decomposition product of nitrosoperoxycarbonate.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(16):4571-81.
2007: Fabián A Rodríguez; Yuqin Cai; Chin Lin; Yijin Tang; Alexander Kolbanovskiy; Shantu Amin; Dinshaw J Patel; Suse Broyde; Nicholas E Geacintov
Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context.
Nucleic acids research 2007;35(5):1555-68.
2006: Alexander Durandin; Lei Jia; Conor Crean; Alexander Kolbanovskiy; Shuang Ding; Vladimir Shafirovich; Suse Broyde; Nicholas E Geacintov
Assignment of absolute configurations of the enantiomeric spiroiminodihydantoin nucleobases by experimental and computational optical rotatory dispersion methods.
Chemical research in toxicology 2006;19(7):908-13.
2006: Yelena Margolin; Jean-Francois Cloutier; Vladimir Shafirovich; Nicholas E Geacintov; Peter C Dedon
Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation.
Nature chemical biology 2006;2(7):365-6.
2006: Lei Jia; Vladimir Shafirovich; Robert Shapiro; Nicholas E Geacintov; Suse Broyde
Flexible 5-guanidino-4-nitroimidazole DNA lesions: structures and thermodynamics.
Biochemistry 2006;45(21):6644-55.
2006: Oksana M Subach; Vladimir B Baskunov; Maria V Darii; Diana V Maltseva; Dmitrii A Alexandrov; Olga V Kirsanova; Alexander Kolbanovskiy; Marina Kolbanovskiy; Francis Johnson; Radha Bonala; Nicholas E Geacintov; Elizaveta S Gromova
Impact of benzo[a]pyrene-2'-deoxyguanosine lesions on methylation of DNA by SssI and HhaI DNA methyltransferases.
Biochemistry 2006;45(19):6142-59.
2006: Maksim Royzen; Alexander Durandin; Victor G Young; Nicholas E Geacintov; James W Canary
A sensitive probe for the detection of Zn(II) by time-resolved fluorescence.
Journal of the American Chemical Society 2006;128(12):3854-5.
2006: Bo Zhao; Jillian Wang; Nicholas E Geacintov; Zhigang Wang
Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells.
Nucleic acids research 2006;34(2):417-25.
2006: Olga Rechkoblit; Lucy Malinina; Yuan Cheng; Vitaly Kuryavyi; Suse Broyde; Nicholas E Geacintov; Dinshaw J Patel
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion.
PLoS biology 2006;4(1):e11.
2005: Shuang Ding; Robert Shapiro; Nicholas E Geacintov; Suse Broyde
Equilenin-derived DNA adducts to cytosine in DNA duplexes: structures and thermodynamics.
Biochemistry 2005;44(44):14565-76.
2005: Alexander Kolbanovskiy; Vladimir Kuzmin; Anant Shastry; Marina Kolbanovskaya; Dandan Chen; Minsun Chang; Judy L Bolton; Nicholas E Geacintov
Base selectivity and effects of sequence and DNA secondary structure on the formation of covalent adducts derived from the equine estrogen metabolite 4-hydroxyequilenin.
Chemical research in toxicology 2005;18(11):1737-47.
2005: Lei Jia; Vladimir Shafirovich; Robert Shapiro; Nicholas E Geacintov; Suse Broyde
Structural and thermodynamic features of spiroiminodihydantoin damaged DNA duplexes.
Biochemistry 2005;44(40):13342-53.
2005: Conor Crean; Nicholas E Geacintov; Vladimir Shafirovich
Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: insight from oxygen-18 labeling experiments.
Angewandte Chemie (International ed. in English) 2005;44(32):5057-60.
2005: Naomi Suzuki; Manabu Yasui; Nicholas E Geacintov; Vladimir Shafirovich; Shinya Shibutani
Miscoding events during DNA synthesis past the nitration-damaged base 8-nitroguanine.
Biochemistry 2005;44(25):9238-45.
2005: Lei Jia; Vladimir Shafirovich; Robert Shapiro; Nicholas E Geacintov; Suse Broyde
Spiroiminodihydantoin lesions derived from guanine oxidation: structures, energetics, and functional implications.
Biochemistry 2005;44(16):6043-51.
2005: Na Zhang; Chin Lin; Xuanwei Huang; Alexander Kolbanovskiy; Brian E Hingerty; Shantu Amin; Suse Broyde; Nicholas E Geacintov; Dinshaw J Patel
Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.
Journal of molecular biology 2005;346(4):951-65.
2005: Lihua Wang; Min Wu; Shi Fang Yan; Dinshaw J Patel; Nicholas E Geacintov; Suse Broyde
Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations.
Chemical research in toxicology 2005;18(3):441-56.
2005: Richard Misiaszek; Yuriy Uvaydov; Conor Crean; Nicholas E Geacintov; Vladimir Shafirovich
Combination reactions of superoxide with 8-Oxo-7,8-dihydroguanine radicals in DNA: kinetics and end products.
The Journal of biological chemistry 2005;280(8):6293-300.
2005: Richard Misiaszek; Conor Crean; Nicholas E Geacintov; Vladimir Shafirovich
Combination of nitrogen dioxide radicals with 8-oxo-7,8-dihydroguanine and guanine radicals in DNA: oxidation and nitration end-products.
Journal of the American Chemical Society 2005;127(7):2191-200.
2005: Gerald W Hsu; Xuanwei Huang; Natalia P Luneva; Nicholas E Geacintov; Lorena S Beese
Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication.
The Journal of biological chemistry 2005;280(5):3764-70.
2005: Vladimir B Baskunov; Fedor V. Subach; Alexander Kolbanovskiy; Marina Kolbanovskiy; Sergei A Eremin; Francis Johnson; Radha Bonala; Nicholas E Geacintov; Elizaveta S Gromova
Effects of benzo[a]pyrene-deoxyguanosine lesions on DNA methylation catalyzed by EcoRII DNA methyltransferase and on DNA cleavage effected by EcoRII restriction endonuclease.
Biochemistry 2005;44(3):1054-66.
2005: Yiyong Liu; Zhengguan Yang; Christopher D Utzat; Yu Liu; Nicholas E Geacintov; Ashis K Basu; Yue Zou
Interactions of human replication protein A with single-stranded DNA adducts.
The Biochemical journal 2005;385(Pt 2):519-26.
2004: Min Wu; Shi Fang Yan; Jian Tan; Dinshaw J Patel; Nicholas E Geacintov; Suse Broyde
Conformational searches elucidate effects of stereochemistry on structures of deoxyadenosine covalently bound to tumorigenic metabolites of benzo[C] phenanthrene.
Frontiers in bioscience : a journal and virtual library 2004;9():2807-18.
2004: Rebecca A Perlow-Poehnelt; Ilya Likhterov; David A Scicchitano; Nicholas E Geacintov; Suse Broyde
The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches.
The Journal of biological chemistry 2004;279(35):36951-61.
2004: Richard Misiaszek; Conor Crean; Avrum Joffe; Nicholas E Geacintov; Vladimir Shafirovich
Oxidative DNA damage associated with combination of guanine and superoxide radicals and repair mechanisms via radical trapping.
The Journal of biological chemistry 2004;279(31):32106-15.
2004: Shi Fang Yan; Min Wu; Nicholas E Geacintov; Suse Broyde
Altering DNA polymerase incorporation fidelity by distorting the dNTP binding pocket with a bulky carcinogen-damaged template.
Biochemistry 2004;43(24):7750-65.
2004: Yue Zou; Huaxian Ma; Irina G Minko; Steven M Shell; Zhengguan Yang; Youxing Qu; Ying Xu; Nicholas E Geacintov; R Stephen Lloyd
DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repair.
Biochemistry 2004;43(14):4196-205.
2003: Avrum Joffe; Nicholas E Geacintov; Vladimir Shafirovich
DNA lesions derived from the site selective oxidation of Guanine by carbonate radical anions.
Chemical research in toxicology 2003;16(12):1528-38.
2003: Yue Zou; Steven M Shell; Christopher D Utzat; Charlie Luo; Zhengguan Yang; Nicholas E Geacintov; Ashis K Basu
Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease.
Biochemistry 2003;42(43):12654-61.
2003: Thomas M Schinecker; Rebecca A Perlow; Suse Broyde; Nicholas E Geacintov; David A Scicchitano
Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences.
Nucleic acids research 2003;31(20):6004-15.
2003: Zhongwen Xie; Elena Braithwaite; Dongyu Guo; Bo Zhao; Nicholas E Geacintov; Zhigang Wang
Mutagenesis of benzo[a]pyrene diol epoxide in yeast: requirement for DNA polymerase zeta and involvement of DNA polymerase eta.
Biochemistry 2003;42(38):11253-62.
2003: Avrum Joffe; Steven Mock; Byeong Hwa Yun; Alexander Kolbanovskiy; Nicholas E Geacintov; Vladimir Shafirovich
Oxidative generation of guanine radicals by carbonate radicals and their reactions with nitrogen dioxide to form site specific 5-guanidino-4-nitroimidazole lesions in oligodeoxynucleotides.
Chemical research in toxicology 2003;16(8):966-73.
2003: Shuang Ding; Robert Shapiro; Nicholas E Geacintov; Suse Broyde
Conformations of stereoisomeric base adducts to 4-hydroxyequilenin.
Chemical research in toxicology 2003;16(6):695-707.
2003: Shixiang Yan; Min Wu; Dinshaw J Patel; Nicholas E Geacintov; Suse Broyde
Simulating structural and thermodynamic properties of carcinogen-damaged DNA.
Biophysical journal 2003;84(4):2137-48.
2003: Rebecca A Perlow; Thomas M Schinecker; Se Jun Kim; Nicholas E Geacintov; David A Scicchitano
Construction and purification of site-specifically modified DNA templates for transcription assays.
Nucleic acids research 2003;31(7):e40.
2003: Regula Muheim; Tonko Buterin; Katharine C Colgate; Alexander Kolbanovsij; Nicholas E Geacintov; Hanspeter Naegeli
Modulation of human nucleotide excision repair by 5-methylcytosines.
Biochemistry 2003;42(11):3247-54.
2003: Xuanwei Huang; Alexander Kolbanovskiy; Xiaohua Wu; Yanbin Zhang; Zhigang Wang; Ping Zhuang; Shantu Amin; Nicholas E Geacintov
Effects of base sequence context on translesion synthesis past a bulky (+)-trans-anti-B[a]P-N2-dG lesion catalyzed by the Y-family polymerase pol kappa.
Biochemistry 2003;42(8):2456-66.
2003: Shixiang Yan; Min Wu; Tonko Buterin; Hanspeter Naegeli; Nicholas E Geacintov; Suse Broyde
Role of base sequence context in conformational equilibria and nucleotide excision repair of benzo[a]pyrene diol epoxide-adenine adducts.
Biochemistry 2003;42(8):2339-54.
2003: Toshihiro Ihara; Takashi Ikegami; Tomohiro Fujii; Yusuke Kitamura; Shinji Sueda; Makoto Takagi; Nicholas E Geacintov; Akinori Jyo
Metal ion-directed outside binding of small DNA ligand.
Nucleic acids research. Supplement (2001) 2003;(3):85-6.
2002: Yanbin Zhang; Xiaohua Wu; Dongyu Guo; Olga Rechkoblit; Nicholas E Geacintov; Zhigang Wang
Two-step error-prone bypass of the (+)- and (-)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases eta and kappa.
Mutation research 2002;510(1-2):23-35.
2002: Yanbin Zhang; Xiaohua Wu; Dongyu Guo; Olga Rechkoblit; John-Stephen Taylor; Nicholas E Geacintov; Zhigang Wang
Lesion bypass activities of human DNA polymerase mu.
The Journal of biological chemistry 2002;277(46):44582-7.
2002: Nicholas E Geacintov; Suse Broyde; Tonko Buterin; Hanspeter Naegeli; Min Wu; Shixiang Yan; Dinshaw J Patel
Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery.
Biopolymers 2002;65(3):202-10.
2002: Olga Rechkoblit; Yanbin Zhang; Dongyu Guo; Zhigang Wang; Shantu Amin; Jacek Krzeminsky; Natalia Louneva; Nicholas E Geacintov
trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases.
The Journal of biological chemistry 2002;277(34):30488-94.
2002: Rebecca A Perlow; Alexander Kolbanovskii; Brian E Hingerty; Nicholas E Geacintov; Suse Broyde; David A Scicchitano
DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner.
Journal of molecular biology 2002;321(1):29-47.
2002: Tonko Buterin; Martin T Hess; Daniela Gunz; Nicholas E Geacintov; Leon H F Mullenders; Hanspeter Naegeli
Trapping of DNA nucleotide excision repair factors by nonrepairable carcinogen adducts.
Cancer research 2002;62(15):4229-35.
2002: Min Wu; Shixiang Yan; Dinshaw J Patel; Nicholas E Geacintov; Suse Broyde
Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability.
Nucleic acids research 2002;30(15):3422-32.
2002: Naomi Suzuki; Eiji Ohashi; Alexander Kolbanovskiy; Nicholas E Geacintov; Arthur P Grollman; Haruo Ohmori; Shinya Shibutani
Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).
Biochemistry 2002;41(19):6100-6.
2002: Shixiang Yan; Min Wu; Shuang Ding; Nicholas E Geacintov; Suse Broyde
Conformational analysis of a 4-hydroxyequilenin Guanine adduct using density functional theory.
Chemical research in toxicology 2002;15(5):648-53.
2002: Vladimir Shafirovich; Steven Mock; Alexander Kolbanovskiy; Nicholas E Geacintov
Photochemically catalyzed generation of site-specific 8-nitroguanine adducts in DNA by the reaction of long-lived neutral guanine radicals with nitrogen dioxide.
Chemical research in toxicology 2002;15(4):591-7.
2002: Yanbin Zhang; Xiaohua Wu; Olga Rechkoblit; Nicholas E Geacintov; John-Stephen Taylor; Zhigang Wang
Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion.
Nucleic acids research 2002;30(7):1630-8.
2002: Xuanwei Huang; Katharine C Colgate; Alexander Kolbanovskiy; Shantu Amin; Nicholas E Geacintov
Conformational changes of a benzo[a]pyrene diol epoxide-N(2)-dG adduct induced by a 5'-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context.
Chemical research in toxicology 2002;15(3):438-44.
2002: Qian Ruan; Alexander Kolbanovskiy; Ping Zhuang; Junxin Chen; Jacek Krzeminski; Shantu Amin; Nicholas E Geacintov
Synthesis and characterization of site-specific and stereoisomeric fjord dibenzo[a,l]pyrene diol epoxide-N(6)-adenine adducts: unusual thermal stabilization of modified DNA duplexes.
Chemical research in toxicology 2002;15(2):249-61.
2002: Weidong Huang; Shantu Amin; Nicholas E Geacintov
Fluorescence characteristics of site-specific and stereochemically distinct benzo[a]pyrene diol epoxide-DNA adducts as probes of adduct conformation.
Chemical research in toxicology 2002;15(2):118-26.
2001: Min Wu; Shixiang Yan; Dinshaw J Patel; Nicholas E Geacintov; Suse Broyde
Cyclohexene ring and Fjord region twist inversion in stereoisomeric DNA adducts of enantiomeric benzo[c]phenanthrene diol epoxides.
Chemical research in toxicology 2001;14(12):1629-42.
2001: Qian Ruan; Ping Zhuang; S Li; Rebecca A Perlow; A R Srinivasan; Xiang-Jun Lu; Suse Broyde; Wilma K Olson; Nicholas E Geacintov
Base sequence effects in bending induced by bulky carcinogen-DNA adducts: experimental and computational analysis.
Biochemistry 2001;40(35):10458-72.
2001: Sherry Yan; R Shapiro; Nicholas E Geacintov; Suse Broyde
Stereochemical, structural, and thermodynamic origins of stability differences between stereoisomeric benzo[a]pyrene diol epoxide deoxyadenosine adducts in a DNA mutational hot spot sequence.
Journal of the American Chemical Society 2001;123(29):7054-66.
2001: Vladimir Shafirovich; A Dourandin; W Huang; Nicholas E Geacintov
The carbonate radical is a site-selective oxidizing agent of guanine in double-stranded oligonucleotides.
The Journal of biological chemistry 2001;276(27):24621-6.
2001: Ping Zhuang; Alexander Kolbanovskiy; Shantu Amin; Nicholas E Geacintov
Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I.
Biochemistry 2001;40(22):6660-9.
2001: Olga Rechkoblit; J Krzeminsky; Shantu Amin; B Jernström; Natalia Louneva; Nicholas E Geacintov
Influence of bulky polynuclear carcinogen lesions in a TATA promoter sequence on TATA binding protein-DNA complex formation.
Biochemistry 2001;40(19):5622-32.
2001: R B Roth; Shantu Amin; Nicholas E Geacintov; David A Scicchitano
Bacteriophage T7 RNA polymerase transcription elongation is inhibited by site-specific, stereospecific benzo[c]phenanthrene diol epoxide DNA lesions.
Biochemistry 2001;40(17):5200-7.
2001: C H Lin; X Huang; A Kolbanovskii; Brian E Hingerty; Shantu Amin; Suse Broyde; Nicholas E Geacintov; Dinshaw J Patel
Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity.
Journal of molecular biology 2001;306(5):1059-80.
2001: Vladimir Shafirovich; J Cadet; D Gasparutto; A Dourandin; Nicholas E Geacintov
Nitrogen dioxide as an oxidizing agent of 8-oxo-7,8-dihydro-2'-deoxyguanosine but not of 2'-deoxyguanosine.
Chemical research in toxicology 2001;14(2):233-41.
2000: Yanbin Zhang; Fenghua Yuan; Xiaohua Wu; Olga Rechkoblit; John-Stephen Taylor; Nicholas E Geacintov; Zhigang Wang
Error-prone lesion bypass by human DNA polymerase eta.
Nucleic acids research 2000;28(23):4717-24.
2000: Yanbin Zhang; Fenghua Yuan; Xiaohua Wu; M Wang; Olga Rechkoblit; John-Stephen Taylor; Nicholas E Geacintov; Zhigang Wang
Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro.
Nucleic acids research 2000;28(21):4138-46.
2000: S Hoare; Yue Zou; V Purohit; R Krishnasamy; Milan Skorvaga; Bennett Van Houten; Nicholas E Geacintov; Ashis K Basu
Differential incision of bulky carcinogen-DNA adducts by the UvrABC nuclease: comparison of incision rates and the interactions of Uvr subunits with lesions of different structures.
Biochemistry 2000;39(40):12252-61.
2000: S Shimotakahara; Andrey Gorin; Alexander Kolbanovskiy; A Kettani; Brian E Hingerty; Shantu Amin; Suse Broyde; Nicholas E Geacintov; Dinshaw J Patel
Accomodation of S-cis-tamoxifen-N(2)-guanine adduct within a bent and widened DNA minor groove.
Journal of molecular biology 2000;302(2):377-93.
2000: J Tan; Nicholas E Geacintov; Suse Broyde
Conformational determinants of structures in stereoisomeric cis-opened anti-benzo[a]pyrene diol epoxide adducts to adenine in DNA.
Chemical research in toxicology 2000;13(9):811-22.
2000: Tonko Buterin; Martin T Hess; Natalia P Luneva; Nicholas E Geacintov; S Amin; H Kroth; Albrecht Seidel; Hanspeter Naegeli
Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots.
Cancer research 2000;60(7):1849-56.
2000: A U Khan; D Kovacic; Alexander Kolbanovskiy; M Desai; Krystyna Frenkel; Nicholas E Geacintov
The decomposition of peroxynitrite to nitroxyl anion (NO-) and singlet oxygen in aqueous solution.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):2984-9.
1999: Jianxin Wu; Liya Gu; Hong Wang; Nicholas E Geacintov; Guo-Min Li
Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis.
Molecular and cellular biology 1999;19(12):8292-301.
1999: AK Suri; B Mao; Shantu Amin; Nicholas E Geacintov; Dinshaw J Patel
Solution conformation of the (+)-trans-anti-benzo[g]chrysene-dA adduct opposite dT in a DNA duplex.
Journal of molecular biology 1999;292(2):289-307.
1999: Olga Rechkoblit; Shantu Amin; Nicholas E Geacintov
Primer length dependence of binding of DNA polymerase I Klenow fragment to template-primer complexes containing site-specific bulky lesions.
Biochemistry 1999;38(36):11834-43.
1999: B Mao; Xiaoling kang; Andrey Gorin; J Chen; Brian E Hingerty; Shantu Amin; Suse Broyde; Nicholas E Geacintov; Dinshaw J Patel
Solution structure of the (+)-cis-anti-benzo[a]pyrene-dA ([BP]dA) adduct opposite dT in a DNA duplex.
Biochemistry 1999;38(33):10831-42.
1999: X M Xie; Nicholas E Geacintov; Suse Broyde
Origins of conformational differences between cis and trans DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides.
Chemical research in toxicology 1999;12(7):597-609.
1999: X M Xie; Nicholas E Geacintov; Suse Broyde
Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials.
Biochemistry 1999;38(10):2956-68.
1999: Vladimir Shafirovich; A Dourandin; Natalia P Luneva; C Singh; F Kirigin; Nicholas E Geacintov
Multiphoton near-infrared femtosecond laser pulse-induced DNA damage with and without the photosensitizer proflavine.
Photochemistry and photobiology 1999;69(3):265-74.
1999: R Shukla; Nicholas E Geacintov; Edward L Loechler
The major, N2-dG adduct of (+)-anti-B[a]PDE induces G-->A mutations in a 5'-AGA-3' sequence context.
Carcinogenesis 1999;20(2):261-8.
1998: J Ni; T Liu; Alexander Kolbanovskiy; Jacek Krzeminski; Shantu Amin; Nicholas E Geacintov
Mass spectrometric sequencing of site-specific carcinogen-modified oligodeoxyribonucleotides containing bulky benzo[a]pyrene diol epoxide-deoxyguanosyl adducts.
Analytical biochemistry 1998;264(2):222-9.
1998: H Tsao; B Mao; Ping Zhuang; R Xu; Shantu Amin; Nicholas E Geacintov
Sequence dependence and characteristics of bends induced by site-specific polynuclear aromatic carcinogen-deoxyguanosine lesions in oligonucleotides.
Biochemistry 1998;37(14):4993-5000.
1998: N Pirogov; Vladimir Shafirovich; Alexander Kolbanovskiy; K Solntsev; S A Courtney; Shantu Amin; Nicholas E Geacintov
Role of hydrophobic effects in the reaction of a polynuclear aromatic diol epoxide with oligodeoxynucleotides in aqueous solutions.
Chemical research in toxicology 1998;11(4):381-8.
1998: R Xu; B Mao; Shantu Amin; Nicholas E Geacintov
Bending and circularization of site-specific and stereoisomeric carcinogen-DNA adducts.
Biochemistry 1998;37(2):769-78.
1997: C E Swenberg; Y N Vaishnav; B Li; H Tsao; B Mao; Nicholas E Geacintov
Single-strand breaks in oligodeoxyribonucleotides induced by fission neutrons and gamma radiation and measured by gel electrophoresis: protective effects of aminothiols.
Journal of radiation research 1997;38(4):241-54.
1997: Martin T Hess; Daniela Gunz; Natalia P Luneva; Nicholas E Geacintov; Hanspeter Naegeli
Base pair conformation-dependent excision of benzo[a]pyrene diol epoxide-guanine adducts by human nucleotide excision repair enzymes.
Molecular and cellular biology 1997;17(12):7069-76.
1997: B Feng; Andrey Gorin; Alexander Kolbanovskiy; Brian E Hingerty; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (-)-trans-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.
Biochemistry 1997;36(45):13780-90.
1997: B Feng; Andrey Gorin; Brian E Hingerty; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Structural alignment of the (+)-trans-anti-benzo[a]pyrene-dG adduct positioned opposite dC at a DNA template-primer junction.
Biochemistry 1997;36(45):13769-79.
1997: R Shukla; SA Jelinsky; Tong Liu; Nicholas E Geacintov; Edward L Loechler
How stereochemistry affects mutagenesis by N2-deoxyguanosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene: configuration of the adduct bond is more important than those of the hydroxyl groups.
Biochemistry 1997;36(43):13263-9.
1997: Yu-Jing Zhang; Nicholas E Geacintov; Regina M Santella
Development of a monoclonal antibody recognizing benzo[c]phenanthrenediol epoxide-DNA adducts: application to immunohistochemical detection of DNA damage.
Chemical research in toxicology 1997;10(9):948-52.
1997: R Shukla; Tong Liu; Nicholas E Geacintov; Edward L Loechler
The major, N2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G --> A) in a 5'-CGT-3' sequence context.
Biochemistry 1997;36(33):10256-61.
1997: C J Hanrahan; Manny Bacolod; R R Vyas; T Liu; Nicholas E Geacintov; Edward L Loechler; Ashis K Basu
Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells.
Chemical research in toxicology 1997;10(4):369-77.
1997: Nicholas E Geacintov; Monique Cosman; Brian E Hingerty; Shantu Amin; Suse Broyde; Dinshaw J Patel
NMR solution structures of stereoisometric covalent polycyclic aromatic carcinogen-DNA adduct: principles, patterns, and diversity.
Chemical research in toxicology 1997;10(2):111-46.
1996: D J Choi; R B Roth; T Liu; Nicholas E Geacintov; David A Scicchitano
Incorrect base insertion and prematurely terminated transcripts during T7 RNA polymerase transcription elongation past benzo[a]pyrenediol epoxide-modified DNA.
Journal of molecular biology 1996;264(2):213-9.
1996: R Xu; S Dwarakanath; M Cosman; Shantu Amin; Nicholas E Geacintov
Site-specific adducts derived from the binding of anti-5-methylchrysene diol epoxide enantiomers to DNA: synthesis and characteristics.
Carcinogenesis 1996;17(9):2035-42.
1996: M Cosman; Brian E Hingerty; N Luneva; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (-)-cis-anti-benzo[a]pyrenyl-dG adduct opposite dC in a DNA duplex: intercalation of the covalently attached BP ring into the helix with base displacement of the modified deoxyguanosine into the major groove.
Biochemistry 1996;35(30):9850-63.
1996: T Liu; J Xu; H Tsao; B Li; R Xu; C Yang; Shantu Amin; M Moriya; Nicholas E Geacintov
Base sequence-dependent bends in site-specific benzo[a]pyrene diol epoxide-modified oligonucleotide duplexes.
Chemical research in toxicology 1996;9(1):255-61.
1995: M Cosman; Brian E Hingerty; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Structural alignments of (+)- and (-)-trans-anti-benzo[a]pyrene-dG adducts positioned at a DNA template-primer junction.
Biochemistry 1995;34(46):15334-50.
1995: H Margolis-Nunno; R Robinson; B Horowitz; Nicholas E Geacintov; E Ben-Hur
Psoralen-mediated virus photoinactivation in platelet concentrates: enhanced specificity of virus kill in the absence of shorter UVA wavelengths.
Photochemistry and photobiology 1995;62(5):917-22.
1995: S A Jelinsky; Tong Liu; Nicholas E Geacintov; Edward L Loechler
The major, N2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide is capable of inducing G-->A and G-->C, in addition to G-->T, mutations.
Biochemistry 1995;34(41):13545-53.
1995: T M Hsu; T M Liu; S Amin; Nicholas E Geacintov; Regina M Santella
Determination of stereospecificity of benzo[a]pyrene diolepoxide-DNA antisera with site-specifically modified oligonucleotides.
Carcinogenesis 1995;16(9):2263-5.
1995: R Xu; B Mao; J Xu; B Li; S Birke; C E Swenberg; Nicholas E Geacintov
Stereochemistry-dependent bending in oligonucleotide duplexes induced by site-specific covalent benzo[a]pyrene diol epoxide-guanine lesions.
Nucleic acids research 1995;23(12):2314-9.
1995: M Cosman; R Xu; Brian E Hingerty; Shantu Amin; R G Harvey; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (-)-trans-anti-5-methylchrysene-dG adduct opposite dC in a DNA duplex: DNA bending associated with wedging of the methyl group of 5-methylchrysene to the 3'-side of the modification site.
Biochemistry 1995;34(18):6247-60.
1995: A Laryea; M Cosman; J M Lin; T Liu; R Agarwal; S Smirnov; Shantu Amin; R G Harvey; A Dipple; Nicholas E Geacintov
Direct synthesis and characterization of site-specific adenosyl adducts derived from the binding of a 3,4-dihydroxy-1,2-epoxybenzo[c]phenanthrene stereoisomer to an 11-mer oligodeoxyribonucleotide.
Chemical research in toxicology 1995;8(3):444-54.
1995: B Li; B Mao; T M Liu; J Xu; A Dourandin; Shantu Amin; Nicholas E Geacintov
Laser pulse-induced photochemical strand cleavage of site-specifically and covalently modified (+)-anti-benzo[a]pyrene diol epoxide-oligonucleotide adducts.
Chemical research in toxicology 1995;8(3):396-402.
1995: E Ben-Hur; Nicholas E Geacintov; B Studamire; M E Kenney; B Horowitz
The effect of irradiance on virus sterilization and photodynamic damage in red blood cells sensitized by phthalocyanines.
Photochemistry and photobiology 1995;61(2):190-5.
1995: B Mao; J Xu; B Li; L A Margulis; S Smirnov; N Q Ya; S H Courtney; Nicholas E Geacintov
Synthesis and characterization of covalent adducts derived from the binding of benzo[a]pyrene diol expoxide to a -GGG- sequence in a deoxyoligonucleotide.
Carcinogenesis 1995;16(2):357-65.
1995: M Cosman; A Laryea; R Fiala; Brian E Hingerty; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (-)-trans-anti-benzo[c]phenanthrene-dA ([BPh]dA) adduct opposite dT in a DNA duplex: intercalation of the covalently attached benzo[c]phenanthrenyl ring to the 3'-side of the adduct site and comparison with the (+)-trans-anti-[BPh]dA opposite dT stereoisomer.
Biochemistry 1995;34(4):1295-307.
1994: M Cosman; R Fiala; Brian E Hingerty; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (+)-cis-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.
Biochemistry 1994;33(38):11518-27.
1994: M Cosman; R Fiala; Brian E Hingerty; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (+)-trans-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the major groove.
Biochemistry 1994;33(38):11507-17.
1994: D J Choi; D J Marino-Alessandri; Nicholas E Geacintov; David A Scicchitano
Site-specific benzo[a]pyrene diol epoxide-DNA adducts inhibit transcription elongation by bacteriophage T7 RNA polymerase.
Biochemistry 1994;33(3):780-7.
1993: M Cosman; R Fiala; Brian E Hingerty; A Laryea; H Lee; R G Harvey; Shantu Amin; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (+)-trans-anti-[BPh]dA adduct opposite dT in a DNA duplex: intercalation of the covalently attached benzo[c]phenanthrene to the 5'-side of the adduct site without disruption of the modified base pair.
Biochemistry 1993;32(46):12488-97.
1993: B Mao; B Li; Shantu Amin; M Cosman; Nicholas E Geacintov
Opposite stereoselective resistance to digestion by phosphodiesterases I and II of benzo[a]pyrene diol epoxide-modified oligonucleotide adducts.
Biochemistry 1993;32(44):11785-93.
1993: L Balasta; R Xu; Nicholas E Geacintov; C E Swenberg; Shantu Amin; Stephen S Hecht
Unwinding and hydrodynamic flow linear dichroism characteristics of supercoiled DNA covalently modified with two isomeric methylchrysene diol epoxides of different biological activities.
Chemical research in toxicology 1993;6(5):616-24.
1993: Nicholas E Geacintov; R Zhao; V A Kuzmin; S K Kim; L J Pecora
Mechanisms of quenching of the fluorescence of a benzo[a]pyrene tetraol metabolite model compound by 2'-deoxynucleosides.
Photochemistry and photobiology 1993;58(2):185-94.
1993: J Chen; M C MacLeod; R Zhao; Nicholas E Geacintov
Fluorescence HPLC methods for detecting benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide-deoxyadenosine adducts in enzyme-digests of modified DNA: improved sensitivity.
Carcinogenesis 1993;14(5):1049-51.
1993: M Cosman; Carlos de los Santos; R Fiala; Brian E Hingerty; V Ibanez; E Luna; R Harvey; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Solution conformation of the (+)-cis-anti-[BP]dG adduct in a DNA duplex: intercalation of the covalently attached benzo[a]pyrenyl ring into the helix and displacement of the modified deoxyguanosine.
Biochemistry 1993;32(16):4145-55.
1993: L A Margulis; V Ibanez; Nicholas E Geacintov
Base-sequence dependence of covalent binding of benzo[a]pyrene diol epoxide to guanine in oligodeoxyribonucleotides.
Chemical research in toxicology 1993;6(1):59-63.
1992: R Xu; S Birke; S E Carberry; Nicholas E Geacintov; C E Swenberg; R G Harvey
Differences in unwinding of supercoiled DNA induced by the two enantiomers of anti-benzo[a]pyrene diol epoxide.
Nucleic acids research 1992;20(23):6167-76.
1992: B Mao; L A Margulis; B Li; V Ibanez; H Lee; R G Harvey; Nicholas E Geacintov
Direct synthesis and identification of benzo[a]pyrene diol epoxide-deoxyguanosine binding sites in modified oligodeoxynucleotides.
Chemical research in toxicology 1992;5(6):773-8.
1992: R Zhao; T M Liu; S K Kim; M C MacLeod; Nicholas E Geacintov
Identification and quantitative detection of isomeric benzo[a]pyrene diolepoxide--DNA adducts by low-temperature conventional fluorescence methods.
Carcinogenesis 1992;13(10):1817-24.
1992: S Rywkin; L Lenny; J Goldstein; Nicholas E Geacintov; H Margolis-Nunno; B Horowitz
Importance of type I and type II mechanisms in the photodynamic inactivation of viruses in blood with aluminum phthalocyanine derivatives.
Photochemistry and photobiology 1992;56(4):463-9.
1992: H Margolis-Nunno; B Williams; S Rywkin; Nicholas E Geacintov; B Horowitz
Virus sterilization in platelet concentrates with psoralen and ultraviolet A light in the presence of quenchers.
Transfusion 1992;32(6):541-7.
1992: Carlos de los Santos; M Cosman; Brian E Hingerty; V Ibanez; L A Margulis; Nicholas E Geacintov; Suse Broyde; Dinshaw J Patel
Influence of benzo[a]pyrene diol epoxide chirality on solution conformations of DNA covalent adducts: the (-)-trans-anti-[BP]G.C adduct structure and comparison with the (+)-trans-anti-[BP]G.C enantiomer.
Biochemistry 1992;31(23):5245-52.
1992: M Cosman; Carlos de los Santos; R Fiala; Brian E Hingerty; Sheo B Singh; V Ibanez; L A Margulis; D Live; Nicholas E Geacintov; Suse Broyde
Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1914-8.
1992: B Horowitz; S Rywkin; H Margolis-Nunno; B Williams; Nicholas E Geacintov; Alfred M Prince; D Pascual; G Ragno; C R Valeri; T Huima-Byron
Inactivation of viruses in red cell and platelet concentrates with aluminum phthalocyanine (AIPc) sulfonates.
Blood cells 1992;18(1):141-9; discussion 150.
1991: Nicholas E Geacintov; M Cosman; B Mao; A Alfano; V Ibanez; R G Harvey
Spectroscopic characteristics and site I/site II classification of cis and trans benzo[a]pyrene diolepoxide enantiomer-guanosine adducts in oligonucleotides and polynucleotides.
Carcinogenesis 1991;12(11):2099-108.
1991: C E Swenberg; S Birke; Nicholas E Geacintov
Characterization of the interaction of the radioprotector 1-methyl-2-[2-(methylthio)-2-piperidinovinyl]quinolinium iodide with supercoiled DNA.
Radiation research 1991;127(2):138-45.
1991: Sheo B Singh; Brian E Hingerty; U C Singh; J P Greenberg; Nicholas E Geacintov; Suse Broyde
Structures of the (+)- and (-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyre ne adducts to guanine-N2 in a duplex dodecamer.
Cancer research 1991;51(13):3482-92.
1991: C J Roche; A M Jeffrey; B Mao; A Alfano; S K Kim; V Ibanez; Nicholas E Geacintov
Dependence of conformations of benzo[a]pyrene diol epoxide-DNA adducts derived from stereoisomers of different tumorigenicities on base sequence.
Chemical research in toxicology 1991;4(3):311-7.
1991: L Valkunas; Nicholas E Geacintov; L France; J Breton
The dependence of the shapes of fluorescence induction curves in chloroplasts on the duration of illumination pulses.
Biophysical journal 1991;59(2):397-408.
1991: B Horowitz; B Williams; S Rywkin; Alfred M Prince; D Pascual; Nicholas E Geacintov; J Valinsky
Inactivation of viruses in blood with aluminum phthalocyanine derivatives.
Transfusion 1991;31(2):102-8.
1991: Nicholas E Geacintov; C E Swenberg
Chemical, molecular biology, and genetic techniques for correlating DNA base damage induced by ionizing radiation with biological end points.
Basic life sciences 1991;58():453-73; discussion 473-4.
1990: C E Swenberg; S E Carberry; Nicholas E Geacintov
Linear dichroism characteristics of ethidium-and proflavine-supercoiled DNA complexes.
Biopolymers 1990;29(14):1735-44.
1990: M Cosman; V Ibanez; Nicholas E Geacintov; R G Harvey
Preparation and isolation of adducts in high yield derived from the binding of two benzo[a]pyrene-7,8-dihydroxy-9,10-oxide stereoisomers to the oligonucleotide d(ATATGTATA).
Carcinogenesis 1990;11(9):1667-72.
1990: Nicholas E Geacintov; M S Lee; V Ibanez; Shantu Amin; Stephen S Hecht
Differences in conformations of covalent adducts derived from the binding of 5- and 6-methylchrysene diol epoxide stereoisomers to DNA.
Carcinogenesis 1990;11(6):985-9.
1989: C J Roche; Nicholas E Geacintov; V Ibanez; R G Harvey
Linear dichroism properties and orientations of different ultraviolet transition moments of benzo[a]pyrene derivatives bound noncovalently and covalently to DNA.
Biophysical chemistry 1989;33(3):277-88.
1989: S K Kim; Nicholas E Geacintov; H C Brenner; R G Harvey
Identification of conformationally different binding sites in benzo[a]pyrene diol epoxide--DNA adducts by low-temperature fluorescence spectroscopy.
Carcinogenesis 1989;10(7):1333-5.
1989: L P van Houte; Rienk van Grondelle; J Retèl; J G Westra; D Zinger; John C Sutherland; S K Kim; Nicholas E Geacintov
Excited state properties of the N-(deoxyguanosin-8-yl)-2-aminofluorene adducts.
Photochemistry and photobiology 1989;49(4):387-94.
1989: S E Carberry; Nicholas E Geacintov; R G Harvey
Reactions of stereoisomeric non-bay-region benz[a]anthracene diol epoxides with DNA and conformations of non-covalent complexes and covalent adducts.
Carcinogenesis 1989;10(1):97-103.
1989: S K Kim; Nicholas E Geacintov; D Zinger; John C Sutherland
Fluorescence spectral characteristics and fluorescence decay profiles of covalent polycyclic aromatic carcinogen-DNA adducts.
Basic life sciences 1989;51():187-205.
1988: Nicholas E Geacintov; M Shahbaz; V Ibanez; K Moussaoui; R G Harvey
Base-sequence dependence of noncovalent complex formation and reactivity of benzo[a]pyrene diol epoxide with polynucleotides.
Biochemistry 1988;27(22):8380-7.
1988: S E Carberry; M Shahbaz; Nicholas E Geacintov; R G Harvey
Reactions of stereoisomeric and structurally related bay region diol epoxide derivatives of benz[a]anthracene with DNA. Conformations of noncovalent complexes and covalent carcinogen-DNA adducts.
Chemico-biological interactions 1988;66(1-2):121-45.
1987: D Zinger; Nicholas E Geacintov; R G Harvey
Conformations and selective photodissociation of heterogeneous benzo(a)pyrene diol epoxide enantiomer-DNA adducts.
Biophysical chemistry 1987;27(2):131-8.
1986: M H Kim; C J Roche; Nicholas E Geacintov; M Pope; J Pataki; R G Harvey
Conformations of complexes derived from the interactions of two stereoisomeric bay-region 5-methylchrysene diol epoxides with DNA.
Journal of biomolecular structure & dynamics 1986;3(5):949-65.
1984: Nicholas E Geacintov; H Yoshida; V Ibanez; S A Jacobs; R G Harvey
Conformations of adducts and kinetics of binding to DNA of the optically pure enantiomers of anti-benzo(a)pyrene diol epoxide.
Biochemical and biophysical research communications 1984;122(1):33-9.
1984: Nicholas E Geacintov; V Ibanez; A G Gagliano; S A Jacobs; R G Harvey
Stereoselective covalent binding of anti-benzo(a)pyrene diol epoxide to DNA conformation of enantiomer adducts.
Journal of biomolecular structure & dynamics 1984;1(6):1473-84.
1983: Nicholas E Geacintov; A G Gagliano; V Ibanez; H Lee; S A Jacobs; R G Harvey
Linear dichroism studies of conformations of carcinogen-DNA adducts application to covalent complexes derived from the reactions of the two enantiomers of 9,10-epoxy-9,10,11,12-tetrahydrobenzo(e)pyrene with DNA.
Journal of biomolecular structure & dynamics 1983;1(4):913-23.
1982: A G Gagliano; Nicholas E Geacintov; V Ibanez; R G Harvey; H M Lee
Application of fluorescence and linear dichroism techniques to the characterization of the covalent adducts derived from interaction of (+/-)-trans-9,10-dihydroxy-anti-11,12-epoxy-9,10,11,12-tetrahydro-benzo[e]pyrene with DNA.
Carcinogenesis 1982;3(9):969-76.
1982: Nicholas E Geacintov; A G Gagliano; V Ibanez; R G Harvey
Spectroscopic characterizations and comparisons of the structures of the covalent adducts derived from the reactions of 7, 8-dihydroxy-7,8,9,10-tetrahydrobenzo [a] pyrene-9,10-oxide, and the 9, 10-epoxides of 7,8,9,10-tetrahydrobenzo [a] pyrene and 9.10,11,12-tetrahydrobenzo [e] pyrene with DNA.
Carcinogenesis 1982;3(3):247-53.
1980: Nicholas E Geacintov; V Ibanez; A G Gagliano; H Yoshida; R G Harvey
Kinetics of hydrolysis to tetraols and binding of benzo(a)pyrene-7,8-dihydrodiol-9, 10-oxide and its tetraol derivatives to DNA. Conformation of adducts.
Biochemical and biophysical research communications 1980;92(4):1335-42.