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Nicholas Geacintov

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Concepts & Ideas

Disorders

DNA Damage

Physiology

DNA Repair

Occupations

Thermodynamics

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Co-Publications
Name
63
Broyde, Suse
35
Amin, Shantu
32
Patel, Dinshaw
29
Shafirovich, Vladimir
25
Kolbanovskiy, Alexander
19
Hingerty, Brian
12
Crean, Conor
12
Rechkoblit, Olga
9
Scicchitano, David
9
Wang, Zhigang
9
Wu, Min
9
Ding, Shuang
9
Jia, Lei
8
Mao, B
7
Shapiro, Robert

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Publications

TOP 3
Crean Conor; Shao Jie; Yun Byeong Hwa; Geacintov Nicholas E; Shafirovich Vladimir
The role of one-electron reduction of lipid hydroperoxides in causing DNA damage.
Crean Conor; Geacintov Nicholas E; Shafirovich Vladimir
Methylation of 2'-deoxyguanosine by a free radical mechanism.
Jia Lei; Kropachev Konstantin; Ding Shuang; Van Houten Bennett; Geacintov Nicholas E; Broyde Suse
Exploring damage recognition models in prokaryotic nucleotide excision repair with a benzo[a]pyrene-derived lesion in UvrB.

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All Publications

2009: Crean Conor; Shao Jie; Yun Byeong Hwa; Geacintov Nicholas E; Shafirovich Vladimir
The role of one-electron reduction of lipid hydroperoxides in causing DNA damage.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(40):10634-40.
2009: Crean Conor; Geacintov Nicholas E; Shafirovich Vladimir
Methylation of 2'-deoxyguanosine by a free radical mechanism.
The journal of physical chemistry. B 2009;113(38):12773-81.
2009: Jia Lei; Kropachev Konstantin; Ding Shuang; Van Houten Bennett; Geacintov Nicholas E; Broyde Suse
Exploring damage recognition models in prokaryotic nucleotide excision repair with a benzo[a]pyrene-derived lesion in UvrB.
Biochemistry 2009;48(38):8948-57.
2009: Zhang Na; Ding Shuang; Kolbanovskiy Alexander; Shastry Anant; Kuzmin Vladimir A; Bolton Judy L; Patel Dinshaw J; Broyde Suse; Geacintov Nicholas E
NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms.
Biochemistry 2009;48(30):7098-109.
2009: Ding Shuang; Jia Lei; Durandin Alexander; Crean Conor; Kolbanovskiy Alexander; Shafirovich Vladimir; Broyde Suse; Geacintov Nicholas E
Absolute configurations of spiroiminodihydantoin and allantoin stereoisomers: comparison of computed and measured electronic circular dichroism spectra.
Chemical research in toxicology 2009;22(6):1189-93.
2009: Wang Zhican; Edirisinghe Praneeth; Sohn Johann; Qin Zhihui; Geacintov Nicholas E; Thatcher Gregory R J; Bolton Judy L
Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells.
Chemical research in toxicology 2009;22(6):1129-36.
2009: Xu Pingna; Oum Lida; Lee Yuan-Cho; Geacintov Nicholas E; Broyde Suse
Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase.
Biochemistry 2009;48(22):4677-90.
2009: Rechkoblit Olga; Malinina Lucy; Cheng Yuan; Geacintov Nicholas E; Broyde Suse; Patel Dinshaw J
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases.
Structure (London, England : 1993) 2009;17(5):725-36.
2009: Kropachev Konstantin; Kolbanovskii Marina; Cai Yuqin; Rodríguez Fabian; Kolbanovskii Alexander; Liu Yang; Zhang Lu; Amin Shantu; Patel Dinshaw; Broyde Suse; Geacintov Nicholas E
The sequence dependence of human nucleotide excision repair efficiencies of benzo[a]pyrene-derived DNA lesions: insights into the structural factors that favor dual incisions.
Journal of molecular biology 2009;386(5):1193-203.
2009: Cai Yuqin; Patel Dinshaw J; Geacintov Nicholas E; Broyde Suse
Differential nucleotide excision repair susceptibility of bulky DNA adducts in different sequence contexts: hierarchies of recognition signals.
Journal of molecular biology 2009;385(1):30-44.
2008: Jia Lei; Geacintov Nicholas E; Broyde Suse
The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions.
Nucleic acids research 2008;36(20):6571-84.
2008: Crean Conor; Geacintov Nicholas E; Shafirovich Vladimir
Intrastrand G-U cross-links generated by the oxidation of guanine in 5'-d(GCU) and 5'-r(GCU).
Free radical biology & medicine 2008;45(8):1125-34.
2008: Ding Shuang; Wang Yan; Kolbanovskiy Alexander; Durandin Alexander; Bolton Judy L; van Breemen Richard B; Broyde Suse; Geacintov Nicholas E
Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry.
Chemical research in toxicology 2008;21(9):1739-48.
2008: Crean Conor; Lee Young Ae; Yun Byeong Hwa; Geacintov Nicholas E; Shafirovich Vladimir
Oxidation of guanine by carbonate radicals derived from photolysis of carbonatotetramminecobalt(III) complexes and the pH dependence of intrastrand DNA cross-links mediated by guanine radical reactions.
Chembiochem : a European journal of chemical biology 2008;9(12):1985-91.
2008: Dimitri Alexandra; Jia Lei; Shafirovich Vladimir; Geacintov Nicholas E; Broyde Suse; Scicchitano David A
Transcription of DNA containing the 5-guanidino-4-nitroimidazole lesion by human RNA polymerase II and bacteriophage T7 RNA polymerase.
DNA repair 2008;7(8):1276-88.
2008: Ding Shuang; Shapiro Robert; Cai Yuqin; Geacintov Nicholas E; Broyde Suse
Conformational properties of equilenin-DNA adducts: stereoisomer and base effects.
Chemical research in toxicology 2008;21(5):1064-73.
2008: Broyde Suse; Wang Lihua; Rechkoblit Olga; Geacintov Nicholas E; Patel Dinshaw J
Lesion processing: high-fidelity versus lesion-bypass DNA polymerases.
Trends in biochemical sciences 2008;33(5):209-19.
2008: Xu Pingna; Oum Lida; Geacintov Nicholas E; Broyde Suse
Nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in a Y-family DNA polymerase: a 5'-slippage mechanism.
Biochemistry 2008;47(9):2701-9.
2008: Lee Young Ae; Durandin Alexander; Dedon Peter C; Geacintov Nicholas E; Shafirovich Vladimir
Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: relationship between kinetics and distribution of alkali-labile lesions.
The journal of physical chemistry. B 2008;112(6):1834-44.
2008: Crean Conor; Geacintov Nicholas E; Shafirovich Vladimir
Pathways of arachidonic acid peroxyl radical reactions and product formation with guanine radicals.
Chemical research in toxicology 2008;21(2):358-73.
2008: Crean Conor; Uvaydov Yuriy; Geacintov Nicholas E; Shafirovich Vladimir
Oxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosines.
Nucleic acids research 2008;36(3):742-55.
2008: Broyde Suse; Wang Lihua; Zhang Ling; Rechkoblit Olga; Geacintov Nicholas E; Patel Dinshaw J
DNA adduct structure-function relationships: comparing solution with polymerase structures.
Chemical research in toxicology 2008;21(1):45-52.
2007: Cai Yuqin; Patel Dinshaw J; Geacintov Nicholas E; Broyde Suse
Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, flexible bending, and greater susceptibility to nucleotide excision repair.
Journal of molecular biology 2007;374(2):292-305.
2007: Yun Byeong Hwa; Lee Young Ae; Kim Seog K; Kuzmin Vladimir; Kolbanovskiy Alexander; Dedon Peter C; Geacintov Nicholas E; Shafirovich Vladimir
Photosensitized oxidative DNA damage: from hole injection to chemical product formation and strand cleavage.
Journal of the American Chemical Society 2007;129(30):9321-32.
2007: Mocquet Vincent; Kropachev Konstantin; Kolbanovskiy Marina; Kolbanovskiy Alexander; Tapias Angels; Cai Yuqin; Broyde Suse; Geacintov Nicholas E; Egly Jean-Marc
The human DNA repair factor XPC-HR23B distinguishes stereoisomeric benzo[a]pyrenyl-DNA lesions.
The EMBO journal 2007;26(12):2923-32.
2007: Ruan Qian; Liu Tongming; Kolbanovskiy Alexander; Liu Yang; Ren Jian; Skorvaga Milan; Zou Yue; Lader Joshua; Malkani Brijesh; Amin Shantu; Van Houten Bennett; Geacintov Nicholas E
Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins.
Biochemistry 2007;46(23):7006-15.
2007: Jia Lei; Shafirovich Vladimir; Geacintov Nicholas E; Broyde Suse
Lesion specificity in the base excision repair enzyme hNeil1: modeling and dynamics studies.
Biochemistry 2007;46(18):5305-14.
2007: Subach Oksana M; Maltseva Diana V; Shastry Anant; Kolbanovskiy Alexander; Klimasauskas Saulius; Geacintov Nicholas E; Gromova Elizaveta S
The stereochemistry of benzo[a]pyrene-2'-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases.
The FEBS journal 2007;274(8):2121-34.
2007: Ding Shuang; Shapiro Robert; Geacintov Nicholas E; Broyde Suse
4-hydroxyequilenin-adenine lesions in DNA duplexes: stereochemistry, damage site, and structure.
Biochemistry 2007;46(1):182-91.
2007: Perlow-Poehnelt Rebecca A; Likhterov Ilya; Wang Lihua; Scicchitano David A; Geacintov Nicholas E; Broyde Suse
Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase.
The Journal of biological chemistry 2007;282(2):1397-408.
2007: Xu Pingna; Oum Lida; Beese Lorena S; Geacintov Nicholas E; Broyde Suse
Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.
Nucleic acids research 2007;35(13):4275-88.
2007: Lee Young Ae; Yun Byeong Hwa; Kim Seog K; Margolin Yelena; Dedon Peter C; Geacintov Nicholas E; Shafirovich Vladimir
Mechanisms of oxidation of guanine in DNA by carbonate radical anion, a decomposition product of nitrosoperoxycarbonate.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(16):4571-81.
2007: Rodríguez Fabián A; Cai Yuqin; Lin Chin; Tang Yijin; Kolbanovskiy Alexander; Amin Shantu; Patel Dinshaw J; Broyde Suse; Geacintov Nicholas E
Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context.
Nucleic acids research 2007;35(5):1555-68.
2006: Durandin Alexander; Jia Lei; Crean Conor; Kolbanovskiy Alexander; Ding Shuang; Shafirovich Vladimir; Broyde Suse; Geacintov Nicholas E
Assignment of absolute configurations of the enantiomeric spiroiminodihydantoin nucleobases by experimental and computational optical rotatory dispersion methods.
Chemical research in toxicology 2006;19(7):908-13.
2006: Margolin Yelena; Cloutier Jean-Francois; Shafirovich Vladimir; Geacintov Nicholas E; Dedon Peter C
Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation.
Nature chemical biology 2006;2(7):365-6.
2006: Jia Lei; Shafirovich Vladimir; Shapiro Robert; Geacintov Nicholas E; Broyde Suse
Flexible 5-guanidino-4-nitroimidazole DNA lesions: structures and thermodynamics.
Biochemistry 2006;45(21):6644-55.
2006: Subach Oksana M; Baskunov Vladimir B; Darii Maria V; Maltseva Diana V; Alexandrov Dmitrii A; Kirsanova Olga V; Kolbanovskiy Alexander; Kolbanovskiy Marina; Johnson Francis; Bonala Radha; Geacintov Nicholas E; Gromova Elizaveta S
Impact of benzo[a]pyrene-2'-deoxyguanosine lesions on methylation of DNA by SssI and HhaI DNA methyltransferases.
Biochemistry 2006;45(19):6142-59.
2006: Royzen Maksim; Durandin Alexander; Young Victor G; Geacintov Nicholas E; Canary James W
A sensitive probe for the detection of Zn(II) by time-resolved fluorescence.
Journal of the American Chemical Society 2006;128(12):3854-5.
2006: Rechkoblit Olga; Malinina Lucy; Cheng Yuan; Kuryavyi Vitaly; Broyde Suse; Geacintov Nicholas E; Patel Dinshaw J
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion.
PLoS biology 2006;4(1):e11.
2006: Zhao Bo; Wang Jillian; Geacintov Nicholas E; Wang Zhigang
Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells.
Nucleic acids research 2006;34(2):417-25.
2005: Kolbanovskiy Alexander; Kuzmin Vladimir; Shastry Anant; Kolbanovskaya Marina; Chen Dandan; Chang Minsun; Bolton Judith L; Geacintov Nicholas E
Base selectivity and effects of sequence and DNA secondary structure on the formation of covalent adducts derived from the equine estrogen metabolite 4-hydroxyequilenin.
Chemical research in toxicology 2005;18(11):1737-47.
2005: Ding Shuang; Shapiro Robert; Geacintov Nicholas E; Broyde Suse
Equilenin-derived DNA adducts to cytosine in DNA duplexes: structures and thermodynamics.
Biochemistry 2005;44(44):14565-76.
2005: Jia Lei; Shafirovich Vladimir; Shapiro Robert; Geacintov Nicholas E; Broyde Suse
Structural and thermodynamic features of spiroiminodihydantoin damaged DNA duplexes.
Biochemistry 2005;44(40):13342-53.
2005: Crean Conor; Geacintov Nicholas E; Shafirovich Vladimir
Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: insight from oxygen-18 labeling experiments.
Angewandte Chemie (International ed. in English) 2005;44(32):5057-60.
2005: Suzuki Naomi; Yasui Manabu; Geacintov Nicholas E; Shafirovich Vladimir; Shibutani Shinya
Miscoding events during DNA synthesis past the nitration-damaged base 8-nitroguanine.
Biochemistry 2005;44(25):9238-45.
2005: Jia Lei; Shafirovich Vladimir; Shapiro Robert; Geacintov Nicholas E; Broyde Suse
Spiroiminodihydantoin lesions derived from guanine oxidation: structures, energetics, and functional implications.
Biochemistry 2005;44(16):6043-51.
2005: Wang Lihua; Wu Min; Yan S Frank; Patel Dinshaw J; Geacintov Nicholas E; Broyde Suse
Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations.
Chemical research in toxicology 2005;18(3):441-56.
2005: Zhang Na; Lin Chin; Huang Xuanwei; Kolbanovskiy Aleksandr; Hingerty Brian E; Amin Shantu; Broyde Suse; Geacintov Nicholas E; Patel Dinshaw J
Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.
Journal of molecular biology 2005;346(4):951-65.
2005: Misiaszek Richard; Crean Conor; Geacintov Nicholas E; Shafirovich Vladimir
Combination of nitrogen dioxide radicals with 8-oxo-7,8-dihydroguanine and guanine radicals in DNA: oxidation and nitration end-products.
Journal of the American Chemical Society 2005;127(7):2191-200.
2005: Misiaszek Richard; Uvaydov Yuriy; Crean Conor; Geacintov Nicholas E; Shafirovich Vladimir
Combination reactions of superoxide with 8-Oxo-7,8-dihydroguanine radicals in DNA: kinetics and end products.
The Journal of biological chemistry 2005;280(8):6293-300.
2005: Hsu Gerald W; Huang Xuanwei; Luneva Natalia P; Geacintov Nicholas E; Beese Lorena S
Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication.
The Journal of biological chemistry 2005;280(5):3764-70.
2005: Baskunov Vladimir B; Subach Fedor V; Kolbanovskiy Alexandr; Kolbanovskiy Marina; Eremin Sergei A; Johnson Francis; Bonala Radha; Geacintov Nicholas E; Gromova Elizaveta S
Effects of benzo[a]pyrene-deoxyguanosine lesions on DNA methylation catalyzed by EcoRII DNA methyltransferase and on DNA cleavage effected by EcoRII restriction endonuclease.
Biochemistry 2005;44(3):1054-66.
2005: Liu Yiyong; Yang Zhengguan; Utzat Christopher D; Liu Yu; Geacintov Nicholas E; Basu Ashis K; Zou Yue
Interactions of human replication protein A with single-stranded DNA adducts.
The Biochemical journal 2005;385(Pt 2):519-26.
2004: Wu Min; Yan S Frank; Tan Jian; Patel Dinshaw J; Geacintov Nicholas E; Broyde Suse
Conformational searches elucidate effects of stereochemistry on structures of deoxyadenosine covalently bound to tumorigenic metabolites of benzo[C] phenanthrene.
Frontiers in bioscience : a journal and virtual library 2004;9():2807-18.
2004: Perlow-Poehnelt Rebecca A; Likhterov Ilya; Scicchitano David A; Geacintov Nicholas E; Broyde Suse
The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches.
The Journal of biological chemistry 2004;279(35):36951-61.
2004: Misiaszek Richard; Crean Conor; Joffe Avrum; Geacintov Nicholas E; Shafirovich Vladimir
Oxidative DNA damage associated with combination of guanine and superoxide radicals and repair mechanisms via radical trapping.
The Journal of biological chemistry 2004;279(31):32106-15.
2004: Yan S Frank; Wu Min; Geacintov Nicholas E; Broyde Suse
Altering DNA polymerase incorporation fidelity by distorting the dNTP binding pocket with a bulky carcinogen-damaged template.
Biochemistry 2004;43(24):7750-65.
2004: Zou Yue; Ma Huaxian; Minko Irina G; Shell Steven M; Yang Zhengguan; Qu Youxing; Xu Ying; Geacintov Nicholas E; Lloyd R Stephen
DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repair.
Biochemistry 2004;43(14):4196-205.
2003: Joffe Avrum; Geacintov Nicholas E; Shafirovich Vladimir
DNA lesions derived from the site selective oxidation of Guanine by carbonate radical anions.
Chemical research in toxicology 2003;16(12):1528-38.
2003: Zou Yue; Shell Steven M; Utzat Christopher D; Luo Charlie; Yang Zhengguan; Geacintov Nicholas E; Basu Ashis K
Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease.
Biochemistry 2003;42(43):12654-61.
2003: Schinecker Thomas M; Perlow Rebecca A; Broyde Suse; Geacintov Nicholas E; Scicchitano David A
Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences.
Nucleic acids research 2003;31(20):6004-15.
2003: Xie Zhongwen; Braithwaite Elena; Guo Dongyu; Zhao Bo; Geacintov Nicholas E; Wang Zhigang
Mutagenesis of benzo[a]pyrene diol epoxide in yeast: requirement for DNA polymerase zeta and involvement of DNA polymerase eta.
Biochemistry 2003;42(38):11253-62.
2003: Joffe Avrum; Mock Steven; Yun Byeong Hwa; Kolbanovskiy Alexander; Geacintov Nicholas E; Shafirovich Vladimir
Oxidative generation of guanine radicals by carbonate radicals and their reactions with nitrogen dioxide to form site specific 5-guanidino-4-nitroimidazole lesions in oligodeoxynucleotides.
Chemical research in toxicology 2003;16(8):966-73.
2003: Ding Shuang; Shapiro Robert; Geacintov Nicholas E; Broyde Suse
Conformations of stereoisomeric base adducts to 4-hydroxyequilenin.
Chemical research in toxicology 2003;16(6):695-707.
2003: Yan Shixiang; Wu Min; Patel Dinshaw J; Geacintov Nicholas E; Broyde Suse
Simulating structural and thermodynamic properties of carcinogen-damaged DNA.
Biophysical journal 2003;84(4):2137-48.
2003: Perlow Rebecca A; Schinecker Thomas M; Kim Se Jun; Geacintov Nicholas E; Scicchitano David A
Construction and purification of site-specifically modified DNA templates for transcription assays.
Nucleic acids research 2003;31(7):e40.
2003: Muheim Regula; Buterin Tonko; Colgate Katharine C; Kolbanovsij Alexander; Geacintov Nicholas E; Naegeli Hanspeter
Modulation of human nucleotide excision repair by 5-methylcytosines.
Biochemistry 2003;42(11):3247-54.
2003: Huang Xuanwei; Kolbanovskiy Alexander; Wu Xiaohua; Zhang Yanbin; Wang Zhigang; Zhuang Ping; Amin Shantu; Geacintov Nicholas E
Effects of base sequence context on translesion synthesis past a bulky (+)-trans-anti-B[a]P-N2-dG lesion catalyzed by the Y-family polymerase pol kappa.
Biochemistry 2003;42(8):2456-66.
2003: Yan Shixiang; Wu Min; Buterin Tonko; Naegeli Hanspeter; Geacintov Nicholas E; Broyde Suse
Role of base sequence context in conformational equilibria and nucleotide excision repair of benzo[a]pyrene diol epoxide-adenine adducts.
Biochemistry 2003;42(8):2339-54.
2003: Ihara Toshihiro; Ikegami Takashi; Fujii Tomohiro; Kitamura Yusuke; Sueda Shinji; Takagi Makoto; Geacintov Nicholas E; Jyo Akinori
Metal ion-directed outside binding of small DNA ligand.
Nucleic acids research. Supplement (2001) 2003;(3):85-6.
2002: Zhang Yanbin; Wu Xiaohua; Guo Dongyu; Rechkoblit Olga; Geacintov Nicholas E; Wang Zhigang
Two-step error-prone bypass of the (+)- and (-)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases eta and kappa.
Mutation research 2002;510(1-2):23-35.
2002: Geacintov Nicholas E; Broyde Suse; Buterin Tonko; Naegeli Hanspeter; Wu Min; Yan Shixiang; Patel Dinshaw J
Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery.
Biopolymers 2002;65(3):202-10.
2002: Zhang Yanbin; Wu Xiaohua; Guo Dongyu; Rechkoblit Olga; Taylor John-Stephen; Geacintov Nicholas E; Wang Zhigang
Lesion bypass activities of human DNA polymerase mu.
The Journal of biological chemistry 2002;277(46):44582-7.
2002: Buterin Tonko; Hess Martin T; Gunz Daniela; Geacintov Nicholas E; Mullenders Leon H; Naegeli Hanspeter
Trapping of DNA nucleotide excision repair factors by nonrepairable carcinogen adducts.
Cancer research 2002;62(15):4229-35.
2002: Wu Min; Yan Shixiang; Patel Dinshaw J; Geacintov Nicholas E; Broyde Suse
Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability.
Nucleic acids research 2002;30(15):3422-32.
2002: Perlow Rebecca A; Kolbanovskii Alexander; Hingerty Brian E; Geacintov Nicholas E; Broyde Suse; Scicchitano David A
DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner.
Journal of molecular biology 2002;321(1):29-47.
2002: Rechkoblit Olga; Zhang Yanbin; Guo Dongyu; Wang Zhigang; Amin Shantu; Krzeminsky Jacek; Louneva Natalia; Geacintov Nicholas E
trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases.
The Journal of biological chemistry 2002;277(34):30488-94.
2002: Yan Shixiang; Wu Min; Ding Shuang; Geacintov Nicholas E; Broyde Suse
Conformational analysis of a 4-hydroxyequilenin Guanine adduct using density functional theory.
Chemical research in toxicology 2002;15(5):648-53.
2002: Suzuki Naomi; Ohashi Eiji; Kolbanovskiy Alexander; Geacintov Nicholas E; Grollman Arthur P; Ohmori Haruo; Shibutani Shinya
Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).
Biochemistry 2002;41(19):6100-6.
2002: Shafirovich Vladimir; Mock Steven; Kolbanovskiy Alexander; Geacintov Nicholas E
Photochemically catalyzed generation of site-specific 8-nitroguanine adducts in DNA by the reaction of long-lived neutral guanine radicals with nitrogen dioxide.
Chemical research in toxicology 2002;15(4):591-7.
2002: Zhang Yanbin; Wu Xiaohua; Rechkoblit Olga; Geacintov Nicholas E; Taylor John-Stephen; Wang Zhigang
Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion.
Nucleic acids research 2002;30(7):1630-8.
2002: Huang Xuanwei; Colgate Katharine C; Kolbanovskiy Aleksandr; Amin Shantu; Geacintov Nicholas E
Conformational changes of a benzo[a]pyrene diol epoxide-N(2)-dG adduct induced by a 5'-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context.
Chemical research in toxicology 2002;15(3):438-44.
2002: Ruan Qian; Kolbanovskiy Alexander; Zhuang Ping; Chen Junxin; Krzeminski Jacek; Amin Shantu; Geacintov Nicholas E
Synthesis and characterization of site-specific and stereoisomeric fjord dibenzo[a,l]pyrene diol epoxide-N(6)-adenine adducts: unusual thermal stabilization of modified DNA duplexes.
Chemical research in toxicology 2002;15(2):249-61.
2002: Huang Weidong; Amin Shantu; Geacintov Nicholas E
Fluorescence characteristics of site-specific and stereochemically distinct benzo[a]pyrene diol epoxide-DNA adducts as probes of adduct conformation.
Chemical research in toxicology 2002;15(2):118-26.
2001: Wu M; Yan S; Patel D J; Geacintov N E; Broyde S
Cyclohexene ring and Fjord region twist inversion in stereoisomeric DNA adducts of enantiomeric benzo[c]phenanthrene diol epoxides.
Chemical research in toxicology 2001;14(12):1629-42.
2001: Ruan Q; Zhuang P; Li S; Perlow R; Srinivasan A R; Lu X J; Broyde S; Olson W K; Geacintov N E
Base sequence effects in bending induced by bulky carcinogen-DNA adducts: experimental and computational analysis.
Biochemistry 2001;40(35):10458-72.
2001: Yan S; Shapiro R; Geacintov N E; Broyde S
Stereochemical, structural, and thermodynamic origins of stability differences between stereoisomeric benzo[a]pyrene diol epoxide deoxyadenosine adducts in a DNA mutational hot spot sequence.
Journal of the American Chemical Society 2001;123(29):7054-66.
2001: Shafirovich V; Dourandin A; Huang W; Geacintov N E
The carbonate radical is a site-selective oxidizing agent of guanine in double-stranded oligonucleotides.
The Journal of biological chemistry 2001;276(27):24621-6.
2001: Zhuang P; Kolbanovskiy A; Amin S; Geacintov N E
Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I.
Biochemistry 2001;40(22):6660-9.
2001: Rechkoblit O; Krzeminsky J; Amin S; Jernström B; Louneva N; Geacintov N E
Influence of bulky polynuclear carcinogen lesions in a TATA promoter sequence on TATA binding protein-DNA complex formation.
Biochemistry 2001;40(19):5622-32.
2001: Roth R B; Amin S; Geacintov N E; Scicchitano D A
Bacteriophage T7 RNA polymerase transcription elongation is inhibited by site-specific, stereospecific benzo[c]phenanthrene diol epoxide DNA lesions.
Biochemistry 2001;40(17):5200-7.
2001: Lin C H; Huang X; Kolbanovskii A; Hingerty B E; Amin S; Broyde S; Geacintov N E; Patel D J
Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity.
Journal of molecular biology 2001;306(5):1059-80.
2001: Shafirovich V; Cadet J; Gasparutto D; Dourandin A; Geacintov N E
Nitrogen dioxide as an oxidizing agent of 8-oxo-7,8-dihydro-2'-deoxyguanosine but not of 2'-deoxyguanosine.
Chemical research in toxicology 2001;14(2):233-41.
2000: Zhang Y; Yuan F; Wu X; Rechkoblit O; Taylor J S; Geacintov N E; Wang Z
Error-prone lesion bypass by human DNA polymerase eta.
Nucleic acids research 2000;28(23):4717-24.
2000: Zhang Y; Yuan F; Wu X; Wang M; Rechkoblit O; Taylor J S; Geacintov N E; Wang Z
Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro.
Nucleic acids research 2000;28(21):4138-46.
2000: Hoare S; Zou Y; Purohit V; Krishnasamy R; Skorvaga M; Van Houten B; Geacintov N E; Basu A K
Differential incision of bulky carcinogen-DNA adducts by the UvrABC nuclease: comparison of incision rates and the interactions of Uvr subunits with lesions of different structures.
Biochemistry 2000;39(40):12252-61.
2000: Tan J; Geacintov N E; Broyde S
Conformational determinants of structures in stereoisomeric cis-opened anti-benzo[a]pyrene diol epoxide adducts to adenine in DNA.
Chemical research in toxicology 2000;13(9):811-22.
2000: Shimotakahara S; Gorin A; Kolbanovskiy A; Kettani A; Hingerty B E; Amin S; Broyde S; Geacintov N; Patel D J
Accomodation of S-cis-tamoxifen-N(2)-guanine adduct within a bent and widened DNA minor groove.
Journal of molecular biology 2000;302(2):377-93.
2000: Buterin T; Hess M T; Luneva N; Geacintov N E; Amin S; Kroth H; Seidel A; Naegeli H
Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots.
Cancer research 2000;60(7):1849-56.
2000: Khan A U; Kovacic D; Kolbanovskiy A; Desai M; Frenkel K; Geacintov N E
The decomposition of peroxynitrite to nitroxyl anion (NO-) and singlet oxygen in aqueous solution.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):2984-9.
1999: Wu J; Gu L; Wang H; Geacintov N E; Li G M
Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis.
Molecular and cellular biology 1999;19(12):8292-301.
1999: Rechkoblit O; Amin S; Geacintov N E
Primer length dependence of binding of DNA polymerase I Klenow fragment to template-primer complexes containing site-specific bulky lesions.
Biochemistry 1999;38(36):11834-43.
1999: Suri A K; Mao B; Amin S; Geacintov N E; Patel D J
Solution conformation of the (+)-trans-anti-benzo[g]chrysene-dA adduct opposite dT in a DNA duplex.
Journal of molecular biology 1999;292(2):289-307.
1999: Mao B; Gu Z; Gorin A; Chen J; Hingerty B E; Amin S; Broyde S; Geacintov N E; Patel D J
Solution structure of the (+)-cis-anti-benzo[a]pyrene-dA ([BP]dA) adduct opposite dT in a DNA duplex.
Biochemistry 1999;38(33):10831-42.
1999: Xie X M; Geacintov N E; Broyde S
Origins of conformational differences between cis and trans DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides.
Chemical research in toxicology 1999;12(7):597-609.
1999: Shafirovich V; Dourandin A; Luneva N P; Singh C; Kirigin F; Geacintov N E
Multiphoton near-infrared femtosecond laser pulse-induced DNA damage with and without the photosensitizer proflavine.
Photochemistry and photobiology 1999;69(3):265-74.
1999: Xie X M; Geacintov N E; Broyde S
Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials.
Biochemistry 1999;38(10):2956-68.
1999: Shukla R; Geacintov N E; Loechler E L
The major, N2-dG adduct of (+)-anti-B[a]PDE induces G-->A mutations in a 5'-AGA-3' sequence context.
Carcinogenesis 1999;20(2):261-8.
1998: Ni J; Liu T; Kolbanovskiy A; Krzeminski J; Amin S; Geacintov N E
Mass spectrometric sequencing of site-specific carcinogen-modified oligodeoxyribonucleotides containing bulky benzo[a]pyrene diol epoxide-deoxyguanosyl adducts.
Analytical biochemistry 1998;264(2):222-9.
1998: Pirogov N; Shafirovich V; Kolbanovskiy A; Solntsev K; Courtney S A; Amin S; Geacintov N E
Role of hydrophobic effects in the reaction of a polynuclear aromatic diol epoxide with oligodeoxynucleotides in aqueous solutions.
Chemical research in toxicology 1998;11(4):381-8.
1998: Tsao H; Mao B; Zhuang P; Xu R; Amin S; Geacintov N E
Sequence dependence and characteristics of bends induced by site-specific polynuclear aromatic carcinogen-deoxyguanosine lesions in oligonucleotides.
Biochemistry 1998;37(14):4993-5000.
1998: Xu R; Mao B; Amin S; Geacintov N E
Bending and circularization of site-specific and stereoisomeric carcinogen-DNA adducts.
Biochemistry 1998;37(2):769-78.
1997: Swenberg C E; Vaishnav Y N; Li B; Tsao H; Mao B; Geacintov N E
Single-strand breaks in oligodeoxyribonucleotides induced by fission neutrons and gamma radiation and measured by gel electrophoresis: protective effects of aminothiols.
Journal of radiation research 1997;38(4):241-54.
1997: Hess M T; Gunz D; Luneva N; Geacintov N E; Naegeli H
Base pair conformation-dependent excision of benzo[a]pyrene diol epoxide-guanine adducts by human nucleotide excision repair enzymes.
Molecular and cellular biology 1997;17(12):7069-76.
1997: Feng B; Gorin A; Kolbanovskiy A; Hingerty B E; Geacintov N E; Broyde S; Patel D J
Solution conformation of the (-)-trans-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.
Biochemistry 1997;36(45):13780-90.
1997: Feng B; Gorin A; Hingerty B E; Geacintov N E; Broyde S; Patel D J
Structural alignment of the (+)-trans-anti-benzo[a]pyrene-dG adduct positioned opposite dC at a DNA template-primer junction.
Biochemistry 1997;36(45):13769-79.
1997: Shukla R; Jelinsky S; Liu T; Geacintov N E; Loechler E L
How stereochemistry affects mutagenesis by N2-deoxyguanosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene: configuration of the adduct bond is more important than those of the hydroxyl groups.
Biochemistry 1997;36(43):13263-9.
1997: Zhang Y J; Geacintov N E; Santella R M
Development of a monoclonal antibody recognizing benzo[c]phenanthrenediol epoxide-DNA adducts: application to immunohistochemical detection of DNA damage.
Chemical research in toxicology 1997;10(9):948-52.
1997: Shukla R; Liu T; Geacintov N E; Loechler E L
The major, N2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G --> A) in a 5'-CGT-3' sequence context.
Biochemistry 1997;36(33):10256-61.
1997: Hanrahan C J; Bacolod M D; Vyas R R; Liu T; Geacintov N E; Loechler E L; Basu A K
Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells.
Chemical research in toxicology 1997;10(4):369-77.
1997: Geacintov N E; Cosman M; Hingerty B E; Amin S; Broyde S; Patel D J
NMR solution structures of stereoisometric covalent polycyclic aromatic carcinogen-DNA adduct: principles, patterns, and diversity.
Chemical research in toxicology 1997;10(2):111-46.
1996: Choi D J; Roth R B; Liu T; Geacintov N E; Scicchitano D A
Incorrect base insertion and prematurely terminated transcripts during T7 RNA polymerase transcription elongation past benzo[a]pyrenediol epoxide-modified DNA.
Journal of molecular biology 1996;264(2):213-9.
1996: Xu R; Dwarakanath S; Cosman M; Amin S; Geacintov N E
Site-specific adducts derived from the binding of anti-5-methylchrysene diol epoxide enantiomers to DNA: synthesis and characteristics.
Carcinogenesis 1996;17(9):2035-42.
1996: Cosman M; Hingerty B E; Luneva N; Amin S; Geacintov N E; Broyde S; Patel D J
Solution conformation of the (-)-cis-anti-benzo[a]pyrenyl-dG adduct opposite dC in a DNA duplex: intercalation of the covalently attached BP ring into the helix with base displacement of the modified deoxyguanosine into the major groove.
Biochemistry 1996;35(30):9850-63.
1996: Liu T; Xu J; Tsao H; Li B; Xu R; Yang C; Amin S; Moriya M; Geacintov N E
Base sequence-dependent bends in site-specific benzo[a]pyrene diol epoxide-modified oligonucleotide duplexes.
Chemical research in toxicology 1996;9(1):255-61.
1995: Margolis-Nunno H; Robinson R; Horowitz B; Geacintov N E; Ben-Hur E
Psoralen-mediated virus photoinactivation in platelet concentrates: enhanced specificity of virus kill in the absence of shorter UVA wavelengths.
Photochemistry and photobiology 1995;62(5):917-22.
1995: Cosman M; Hingerty B E; Geacintov N E; Broyde S; Patel D J
Structural alignments of (+)- and (-)-trans-anti-benzo[a]pyrene-dG adducts positioned at a DNA template-primer junction.
Biochemistry 1995;34(46):15334-50.
1995: Jelinsky S A; Liu T; Geacintov N E; Loechler E L
The major, N2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide is capable of inducing G-->A and G-->C, in addition to G-->T, mutations.
Biochemistry 1995;34(41):13545-53.
1995: Hsu T M; Liu T M; Amin S; Geacintov N E; Santella R M
Determination of stereospecificity of benzo[a]pyrene diolepoxide-DNA antisera with site-specifically modified oligonucleotides.
Carcinogenesis 1995;16(9):2263-5.
1995: Xu R; Mao B; Xu J; Li B; Birke S; Swenberg C E; Geacintov N E
Stereochemistry-dependent bending in oligonucleotide duplexes induced by site-specific covalent benzo[a]pyrene diol epoxide-guanine lesions.
Nucleic acids research 1995;23(12):2314-9.
1995: Cosman M; Xu R; Hingerty B E; Amin S; Harvey R G; Geacintov N E; Broyde S; Patel D J
Solution conformation of the (-)-trans-anti-5-methylchrysene-dG adduct opposite dC in a DNA duplex: DNA bending associated with wedging of the methyl group of 5-methylchrysene to the 3'-side of the modification site.
Biochemistry 1995;34(18):6247-60.
1995: Laryea A; Cosman M; Lin J M; Liu T; Agarwal R; Smirnov S; Amin S; Harvey R G; Dipple A; Geacintov N E
Direct synthesis and characterization of site-specific adenosyl adducts derived from the binding of a 3,4-dihydroxy-1,2-epoxybenzo[c]phenanthrene stereoisomer to an 11-mer oligodeoxyribonucleotide.
Chemical research in toxicology 1995;8(3):444-54.
1995: Li B; Mao B; Liu T M; Xu J; Dourandin A; Amin S; Geacintov N E
Laser pulse-induced photochemical strand cleavage of site-specifically and covalently modified (+)-anti-benzo[a]pyrene diol epoxide-oligonucleotide adducts.
Chemical research in toxicology 1995;8(3):396-402.
1995: Ben-Hur E; Geacintov N E; Studamire B; Kenney M E; Horowitz B
The effect of irradiance on virus sterilization and photodynamic damage in red blood cells sensitized by phthalocyanines.
Photochemistry and photobiology 1995;61(2):190-5.
1995: Mao B; Xu J; Li B; Margulis L A; Smirnov S; Ya N Q; Courtney S H; Geacintov N E
Synthesis and characterization of covalent adducts derived from the binding of benzo[a]pyrene diol expoxide to a -GGG- sequence in a deoxyoligonucleotide.
Carcinogenesis 1995;16(2):357-65.
1995: Cosman M; Laryea A; Fiala R; Hingerty B E; Amin S; Geacintov N E; Broyde S; Patel D J
Solution conformation of the (-)-trans-anti-benzo[c]phenanthrene-dA ([BPh]dA) adduct opposite dT in a DNA duplex: intercalation of the covalently attached benzo[c]phenanthrenyl ring to the 3'-side of the adduct site and comparison with the (+)-trans-anti-[BPh]dA opposite dT stereoisomer.
Biochemistry 1995;34(4):1295-307.
1994: Cosman M; Fiala R; Hingerty B E; Amin S; Geacintov N E; Broyde S; Patel D J
Solution conformation of the (+)-cis-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.
Biochemistry 1994;33(38):11518-27.
1994: Cosman M; Fiala R; Hingerty B E; Amin S; Geacintov N E; Broyde S; Patel D J
Solution conformation of the (+)-trans-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the major groove.
Biochemistry 1994;33(38):11507-17.
1994: Choi D J; Marino-Alessandri D J; Geacintov N E; Scicchitano D A
Site-specific benzo[a]pyrene diol epoxide-DNA adducts inhibit transcription elongation by bacteriophage T7 RNA polymerase.
Biochemistry 1994;33(3):780-7.
1993: Cosman M; Fiala R; Hingerty B E; Laryea A; Lee H; Harvey R G; Amin S; Geacintov N E; Broyde S; Patel D
Solution conformation of the (+)-trans-anti-[BPh]dA adduct opposite dT in a DNA duplex: intercalation of the covalently attached benzo[c]phenanthrene to the 5'-side of the adduct site without disruption of the modified base pair.
Biochemistry 1993;32(46):12488-97.
1993: Mao B; Li B; Amin S; Cosman M; Geacintov N E
Opposite stereoselective resistance to digestion by phosphodiesterases I and II of benzo[a]pyrene diol epoxide-modified oligonucleotide adducts.
Biochemistry 1993;32(44):11785-93.
1993: Balasta L; Xu R; Geacintov N E; Swenberg C E; Amin S; Hecht S S
Unwinding and hydrodynamic flow linear dichroism characteristics of supercoiled DNA covalently modified with two isomeric methylchrysene diol epoxides of different biological activities.
Chemical research in toxicology 1993;6(5):616-24.
1993: Geacintov N E; Zhao R; Kuzmin V A; Kim S K; Pecora L J
Mechanisms of quenching of the fluorescence of a benzo[a]pyrene tetraol metabolite model compound by 2'-deoxynucleosides.
Photochemistry and photobiology 1993;58(2):185-94.
1993: Chen J; MacLeod M C; Zhao R; Geacintov N E
Fluorescence HPLC methods for detecting benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide-deoxyadenosine adducts in enzyme-digests of modified DNA: improved sensitivity.
Carcinogenesis 1993;14(5):1049-51.
1993: Cosman M; de los Santos C; Fiala R; Hingerty B E; Ibanez V; Luna E; Harvey R; Geacintov N E; Broyde S; Patel D J
Solution conformation of the (+)-cis-anti-[BP]dG adduct in a DNA duplex: intercalation of the covalently attached benzo[a]pyrenyl ring into the helix and displacement of the modified deoxyguanosine.
Biochemistry 1993;32(16):4145-55.
1993: Margulis L A; Ibanez V; Geacintov N E
Base-sequence dependence of covalent binding of benzo[a]pyrene diol epoxide to guanine in oligodeoxyribonucleotides.
Chemical research in toxicology 1993;6(1):59-63.
1992: Xu R; Birke S; Carberry S E; Geacintov N E; Swenberg C E; Harvey R G
Differences in unwinding of supercoiled DNA induced by the two enantiomers of anti-benzo[a]pyrene diol epoxide.
Nucleic acids research 1992;20(23):6167-76.
1992: Mao B; Margulis L A; Li B; Ibanez V; Lee H; Harvey R G; Geacintov N E
Direct synthesis and identification of benzo[a]pyrene diol epoxide-deoxyguanosine binding sites in modified oligodeoxynucleotides.
Chemical research in toxicology 1992;5(6):773-8.
1992: Zhao R; Liu T M; Kim S K; MacLeod M C; Geacintov N E
Identification and quantitative detection of isomeric benzo[a]pyrene diolepoxide--DNA adducts by low-temperature conventional fluorescence methods.
Carcinogenesis 1992;13(10):1817-24.
1992: Rywkin S; Lenny L; Goldstein J; Geacintov N E; Margolis-Nunno H; Horowitz B
Importance of type I and type II mechanisms in the photodynamic inactivation of viruses in blood with aluminum phthalocyanine derivatives.
Photochemistry and photobiology 1992;56(4):463-9.
1992: Margolis-Nunno H; Williams B; Rywkin S; Geacintov N; Horowitz B
Virus sterilization in platelet concentrates with psoralen and ultraviolet A light in the presence of quenchers.
Transfusion 1992;32(6):541-7.
1992: de los Santos C; Cosman M; Hingerty B E; Ibanez V; Margulis L A; Geacintov N E; Broyde S; Patel D J
Influence of benzo[a]pyrene diol epoxide chirality on solution conformations of DNA covalent adducts: the (-)-trans-anti-[BP]G.C adduct structure and comparison with the (+)-trans-anti-[BP]G.C enantiomer.
Biochemistry 1992;31(23):5245-52.
1992: Cosman M; de los Santos C; Fiala R; Hingerty B E; Singh S B; Ibanez V; Margulis L A; Live D; Geacintov N E; Broyde S
Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1914-8.
1992: Horowitz B; Rywkin S; Margolis-Nunno H; Williams B; Geacintov N; Prince A M; Pascual D; Ragno G; Valeri C R; Huima-Byron T
Inactivation of viruses in red cell and platelet concentrates with aluminum phthalocyanine (AIPc) sulfonates.
Blood cells 1992;18(1):141-9; discussion 150.
1991: Geacintov N E; Cosman M; Mao B; Alfano A; Ibanez V; Harvey R G
Spectroscopic characteristics and site I/site II classification of cis and trans benzo[a]pyrene diolepoxide enantiomer-guanosine adducts in oligonucleotides and polynucleotides.
Carcinogenesis 1991;12(11):2099-108.
1991: Swenberg C E; Birke S; Geacintov N E
Characterization of the interaction of the radioprotector 1-methyl-2-[2-(methylthio)-2-piperidinovinyl]quinolinium iodide with supercoiled DNA.
Radiation research 1991;127(2):138-45.
1991: Singh S B; Hingerty B E; Singh U C; Greenberg J P; Geacintov N E; Broyde S
Structures of the (+)- and (-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyre ne adducts to guanine-N2 in a duplex dodecamer.
Cancer research 1991;51(13):3482-92.
1991: Roche C J; Jeffrey A M; Mao B; Alfano A; Kim S K; Ibanez V; Geacintov N E
Dependence of conformations of benzo[a]pyrene diol epoxide-DNA adducts derived from stereoisomers of different tumorigenicities on base sequence.
Chemical research in toxicology 1991;4(3):311-7.
1991: Horowitz B; Williams B; Rywkin S; Prince A M; Pascual D; Geacintov N; Valinsky J
Inactivation of viruses in blood with aluminum phthalocyanine derivatives.
Transfusion 1991;31(2):102-8.
1991: Geacintov N E; Swenberg C E
Chemical, molecular biology, and genetic techniques for correlating DNA base damage induced by ionizing radiation with biological end points.
Basic life sciences 1991;58():453-73; discussion 473-4.
1990: Swenberg C E; Carberry S E; Geacintov N E
Linear dichroism characteristics of ethidium-and proflavine-supercoiled DNA complexes.
Biopolymers 1990;29(14):1735-44.
1990: Cosman M; Ibanez V; Geacintov N E; Harvey R G
Preparation and isolation of adducts in high yield derived from the binding of two benzo[a]pyrene-7,8-dihydroxy-9,10-oxide stereoisomers to the oligonucleotide d(ATATGTATA).
Carcinogenesis 1990;11(9):1667-72.
1990: Geacintov N E; Lee M S; Ibanez V; Amin S; Hecht S S
Differences in conformations of covalent adducts derived from the binding of 5- and 6-methylchrysene diol epoxide stereoisomers to DNA.
Carcinogenesis 1990;11(6):985-9.
1989: Roche C J; Geacintov N E; Ibanez V; Harvey R G
Linear dichroism properties and orientations of different ultraviolet transition moments of benzo[a]pyrene derivatives bound noncovalently and covalently to DNA.
Biophysical chemistry 1989;33(3):277-88.
1989: Kim S K; Geacintov N E; Brenner H C; Harvey R G
Identification of conformationally different binding sites in benzo[a]pyrene diol epoxide--DNA adducts by low-temperature fluorescence spectroscopy.
Carcinogenesis 1989;10(7):1333-5.
1989: van Houte L P; van Grondelle R; Retèl J; Westra J G; Zinger D; Sutherland J C; Kim S K; Geacintov N E
Excited state properties of the N-(deoxyguanosin-8-yl)-2-aminofluorene adducts.
Photochemistry and photobiology 1989;49(4):387-94.
1989: Carberry S E; Geacintov N E; Harvey R G
Reactions of stereoisomeric non-bay-region benz[a]anthracene diol epoxides with DNA and conformations of non-covalent complexes and covalent adducts.
Carcinogenesis 1989;10(1):97-103.
1989: Kim S K; Geacintov N E; Zinger D; Sutherland J C
Fluorescence spectral characteristics and fluorescence decay profiles of covalent polycyclic aromatic carcinogen-DNA adducts.
Basic life sciences 1989;51():187-205.
1988: Geacintov N E; Shahbaz M; Ibanez V; Moussaoui K; Harvey R G
Base-sequence dependence of noncovalent complex formation and reactivity of benzo[a]pyrene diol epoxide with polynucleotides.
Biochemistry 1988;27(22):8380-7.
1988: Carberry S E; Shahbaz M; Geacintov N E; Harvey R G
Reactions of stereoisomeric and structurally related bay region diol epoxide derivatives of benz[a]anthracene with DNA. Conformations of noncovalent complexes and covalent carcinogen-DNA adducts.
Chemico-biological interactions 1988;66(1-2):121-45.
1987: Zinger D; Geacintov N E; Harvey R G
Conformations and selective photodissociation of heterogeneous benzo(a)pyrene diol epoxide enantiomer-DNA adducts.
Biophysical chemistry 1987;27(2):131-8.
1986: Kim M H; Roche C J; Geacintov N E; Pope M; Pataki J; Harvey R G
Conformations of complexes derived from the interactions of two stereoisomeric bay-region 5-methylchrysene diol epoxides with DNA.
Journal of biomolecular structure & dynamics 1986;3(5):949-65.
1984: Geacintov N E; Yoshida H; Ibanez V; Jacobs S A; Harvey R G
Conformations of adducts and kinetics of binding to DNA of the optically pure enantiomers of anti-benzo(a)pyrene diol epoxide.
Biochemical and biophysical research communications 1984;122(1):33-9.
1984: Geacintov N E; Ibanez V; Gagliano A G; Jacobs S A; Harvey R G
Stereoselective covalent binding of anti-benzo(a)pyrene diol epoxide to DNA conformation of enantiomer adducts.
Journal of biomolecular structure & dynamics 1984;1(6):1473-84.
1983: Geacintov N E; Gagliano A G; Ibanez V; Lee H; Jacobs S A; Harvey R G
Linear dichroism studies of conformations of carcinogen-DNA adducts application to covalent complexes derived from the reactions of the two enantiomers of 9,10-epoxy-9,10,11,12-tetrahydrobenzo(e)pyrene with DNA.
Journal of biomolecular structure & dynamics 1983;1(4):913-23.
1982: Gagliano A G; Geacintov N E; Ibanez V; Harvey R G; Lee H M
Application of fluorescence and linear dichroism techniques to the characterization of the covalent adducts derived from interaction of (+/-)-trans-9,10-dihydroxy-anti-11,12-epoxy-9,10,11,12-tetrahydro-benzo[e]pyrene with DNA.
Carcinogenesis 1982;3(9):969-76.
1982: Geacintov N E; Gagliano A G; Ibanez V; Harvey R G
Spectroscopic characterizations and comparisons of the structures of the covalent adducts derived from the reactions of 7, 8-dihydroxy-7,8,9,10-tetrahydrobenzo [a] pyrene-9,10-oxide, and the 9, 10-epoxides of 7,8,9,10-tetrahydrobenzo [a] pyrene and 9.10,11,12-tetrahydrobenzo [e] pyrene with DNA.
Carcinogenesis 1982;3(3):247-53.
1980: Geacintov N E; Ibanez V; Gagliano A G; Yoshida H; Harvey R G
Kinetics of hydrolysis to tetraols and binding of benzo(a)pyrene-7,8-dihydrodiol-9, 10-oxide and its tetraol derivatives to DNA. Conformation of adducts.
Biochemical and biophysical research communications 1980;92(4):1335-42.

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